Clinical Evidence of Traditional Medicines in Modulating the Immune Response and Diabetic Wound Healing.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-07-16 DOI:10.2174/0115680266359349250707102203

Jyotsana Dwivedi, Pranjal Sachan, Pranay Wal, Ankita Wal, Shanmugam Vippamakula, Rajesh K S, Mukesh Chandra Sharma

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引用次数: 0

Abstract

Background: Diabetes affects over 537 million people, with 20% developing chronic wounds. These wounds are made worse by inflammation, stress, immune problems, and poor blood vessel growth. Plants like Aloe barbadensis, Nigella sativa, and Moringa oleifera contain compounds that help heal wounds by reducing inflammation, stress, and boosting tissue growth.

Objective: This review explains why diabetic wounds heal slowly, focusing on factors like ROS, NO, and immune problems. It also looks at natural compounds that help healing and how traditional medicines can work with modern treatments for better wound care.

Methodology: A systematic literature review was conducted using Scopus, Elsevier, PubMed, ScienceDirect, and Web of Science for studies published between 2000 and 2024. Inclusion criteria comprised clinical trials, preclinical studies, and ethnopharmacological research related to diabetic wound healing, pathophysiology, herbal medicine, active constituents, and mechanisms of action. Studies lacking diabetic wound specificity or methodological clarity were excluded. PRISMA guidelines were followed for study selection and synthesis.

Results: Numerous studies demonstrated that traditional medicines enhance diabetic wound healing by regulating cytokine levels, promoting macrophage polarization, reducing oxidative damage, and remodelling the extracellular matrix. Flavonoids and polyphenols notably improved angiogenesis and tissue repair, while alkaloids and saponins exhibited antimicrobial and anti-inflammatory effects.

Conclusion: Traditional medicinal plants, through their diverse bioactive constituents, offer significant therapeutic potential for diabetic wound care. By targeting key molecular pathways involved in immune regulation and tissue repair, they present a viable adjunct to conventional therapies, potentially improving clinical outcomes in diabetic wound management.

查看原文本刊更多论文

中药调节免疫反应和糖尿病创面愈合的临床证据。

背景：糖尿病影响超过5.37亿人，其中20%患有慢性伤口。这些伤口会因炎症、压力、免疫问题和血管生长不良而恶化。像芦荟、黑草和辣木这样的植物含有的化合物可以通过减少炎症、压力和促进组织生长来帮助伤口愈合。目的：本文综述了糖尿病创面愈合缓慢的原因，重点分析了ROS、NO和免疫问题等因素。它还研究了有助于愈合的天然化合物，以及传统药物如何与现代治疗相结合，以更好地护理伤口。方法：使用Scopus、Elsevier、PubMed、ScienceDirect和Web of Science对2000年至2024年间发表的研究进行了系统的文献综述。入选标准包括与糖尿病伤口愈合、病理生理学、草药、有效成分和作用机制相关的临床试验、临床前研究和民族药理学研究。缺乏糖尿病伤口特异性或方法清晰度的研究被排除在外。遵循PRISMA指南进行研究选择和综合。结果：大量研究表明，传统药物通过调节细胞因子水平、促进巨噬细胞极化、减少氧化损伤和重塑细胞外基质来促进糖尿病创面愈合。黄酮类和多酚类物质显著促进血管生成和组织修复，而生物碱和皂苷具有抗菌和抗炎作用。结论：传统药用植物具有丰富的生物活性成分，对糖尿病创面护理具有重要的治疗潜力。通过靶向参与免疫调节和组织修复的关键分子途径，它们为传统治疗提供了一种可行的辅助手段，可能改善糖尿病伤口管理的临床结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.