Paulo Ricardo da Silva Sanches, Eduardo Maffud Cilli
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引用次数: 0
Abstract
Virus-like particles (VLPs) represent a promising approach to developing vaccines for infectious diseases. These nanostructures mimic the organization and conformation of native viruses but lack viral genetic material, rendering them non-infectious. VLPs can induce potent immune responses, making them ideal immunogens. This review provides an overview of VLP technology, its application in combating infectious diseases, and its potential to shape future vaccine development. Specific emphasis is placed on current clinical applications, emerging infectious disease targets, and the challenges in optimizing VLP-based immunogens.
期刊介绍:
Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.