Barrier Tissue-Resident Macrophages: Natural Compounds as Modulators in Immune Function and Disease.

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-07-17 DOI:10.2174/0115680266369409250701072727

Milena Santos Alves-Silva, Mariana Leite Alves, Vinicius Andrade-Oliveira

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引用次数: 0

Abstract

Tissue-Resident Macrophages (TRMs) are essential cells of the immune system, strategically located in barrier tissues such as the skin, lungs, and intestines. They can originate from progenitor cells in the yolk sac and fetal liver, developing distinct features that enable them to respond effectively to local challenges and maintain tissue homeostasis. The functional plasticity of TRMs allows them to adapt to diverse microenvironments, facilitating their roles in tissue repair, inflammation, and immune surveillance. Recent studies have highlighted the potential of Natural Compounds (NCs) to modulate macrophage function, offering promising therapeutic strategies for managing inflammatory diseases. These compounds have been shown to enhance or suppress specific macrophage activities, influencing immune responses and promoting healing processes. This review highlights the importance of understanding TRMs and the role of natural compounds in modulating TRM activation and function. Deciphering the potential of NCs in macrophages may shed light on the development of innovative treatments for various immune-related diseases.

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屏障组织内巨噬细胞：作为免疫功能和疾病调节剂的天然化合物。

组织常驻巨噬细胞（TRMs）是免疫系统必不可少的细胞，战略性地位于皮肤、肺和肠等屏障组织中。它们可以起源于卵黄囊和胎儿肝脏中的祖细胞，发展出独特的特征，使它们能够有效地应对局部挑战并维持组织稳态。trm的功能可塑性使其能够适应不同的微环境，促进其在组织修复、炎症和免疫监视中的作用。最近的研究强调了天然化合物（NCs）调节巨噬细胞功能的潜力，为管理炎症性疾病提供了有希望的治疗策略。这些化合物已被证明可以增强或抑制特异性巨噬细胞的活性，影响免疫反应并促进愈合过程。这篇综述强调了了解TRM和天然化合物在调节TRM激活和功能中的作用的重要性。破译巨噬细胞中NCs的潜力可能有助于开发各种免疫相关疾病的创新治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.