利用病毒样颗粒作为免疫原治疗传染病。

IF 3.3 4区医学 Q3 CHEMISTRY, MEDICINAL

Current topics in medicinal chemistry Pub Date : 2025-07-17 DOI:10.2174/0115680266364554250628134050

Paulo Ricardo da Silva Sanches, Eduardo Maffud Cilli

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引用次数: 0

摘要

病毒样颗粒（vlp）是开发传染病疫苗的一种很有前途的方法。这些纳米结构模仿天然病毒的组织和构象，但缺乏病毒遗传物质，使其不具有传染性。VLPs可以诱导有效的免疫反应，使其成为理想的免疫原。本文综述了VLP技术及其在传染病防治中的应用，以及它在未来疫苗开发中的潜力。特别强调目前的临床应用，新出现的传染病目标，以及优化基于vlp的免疫原的挑战。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Use of Virus-like Particles as Immunogens to Treat Infectious Diseases.

Virus-like particles (VLPs) represent a promising approach to developing vaccines for infectious diseases. These nanostructures mimic the organization and conformation of native viruses but lack viral genetic material, rendering them non-infectious. VLPs can induce potent immune responses, making them ideal immunogens. This review provides an overview of VLP technology, its application in combating infectious diseases, and its potential to shape future vaccine development. Specific emphasis is placed on current clinical applications, emerging infectious disease targets, and the challenges in optimizing VLP-based immunogens.

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来源期刊

Current topics in medicinal chemistry 医学-医药化学

CiteScore

6.40

自引率

2.90%

发文量

186

审稿时长

3-8 weeks

期刊介绍： Current Topics in Medicinal Chemistry is a forum for the review of areas of keen and topical interest to medicinal chemists and others in the allied disciplines. Each issue is solely devoted to a specific topic, containing six to nine reviews, which provide the reader a comprehensive survey of that area. A Guest Editor who is an expert in the topic under review, will assemble each issue. The scope of Current Topics in Medicinal Chemistry will cover all areas of medicinal chemistry, including current developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, compound diversity measurements, drug absorption, drug distribution, metabolism, new and emerging drug targets, natural products, pharmacogenomics, and structure-activity relationships. Medicinal chemistry is a rapidly maturing discipline. The study of how structure and function are related is absolutely essential to understanding the molecular basis of life. Current Topics in Medicinal Chemistry aims to contribute to the growth of scientific knowledge and insight, and facilitate the discovery and development of new therapeutic agents to treat debilitating human disorders. The journal is essential for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important advances.