Current Topics in Nutraceutical Research最新文献_第5页

Inclusion of Probiotics to Triple Antibiotic Therapy Improves the Outcome of Anti-Helicobacter pylori-Induced Peptic Ulcer 在三联抗生素疗法中加入益生菌可改善抗幽门螺旋杆菌引起的消化性溃疡的治疗效果

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-14 DOI: 10.37290/ctnr2641-452x.21:473-477

Qi Liao, Hui Pan, Zhiwu Zheng, Ying Yu

{"title":"Inclusion of Probiotics to Triple Antibiotic Therapy Improves the Outcome of Anti-Helicobacter pylori-Induced Peptic Ulcer","authors":"Qi Liao, Hui Pan, Zhiwu Zheng, Ying Yu","doi":"10.37290/ctnr2641-452x.21:473-477","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:473-477","url":null,"abstract":"The effects of triple antibiotic therapy plus probiotics on Helicobacter pylori-induced peptic ulcers were assessed. To this end, patients diagnosed with Helicobacter pylori-induced peptic ulcers were divided into control and treatment groups. The control group received standardized triple antibiotic (rabeprazole sodium, amoxicillin, and clarithromycin) therapy, whereas the treatment group also received Compound Eosinophil-Lactobacillus tablets for 14 consecutive days. The treatment outcomes (Helicobacter pylori eradication rate, expression levels of serum procalcitonin, high-sensitivity C-reactive protein, and interleukin-8, and incidence of adverse events) were compared. The effective rate of peptic ulcer control and the eradication rate of Helicobacter pylori were significantly higher for the treatment group than those for the control group (P < 0.05). There was also a significant reduction in pro-inflammatory markers (procalcitonin, high-sensitivity C-reactive protein, and interleukin-8) in the treatment group compared to those in the control group (P < 0.05). Also, the incidence rate of adverse events in the treatment group was lower than that of the control group, but the difference was not statistically significant (P > 0.05). In conclusion, standardized triple antibiotic therapy plus probiotics can effectively improve treatment outcomes and the Helicobacter pylori eradication rate in patients with Helicobacter pylori-induced peptic ulcer.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Network Pharmacology-Based Strategy to Reveal the Mechanism of Action of Cistanche Against Cataracts 基于网络药理学策略揭示肉苁蓉防治白内障的作用机制

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-13 DOI: 10.37290/ctnr2641-452x.21:454-460

Jian Zeng, Zonghan Zhou

{"title":"Network Pharmacology-Based Strategy to Reveal the Mechanism of Action of Cistanche Against Cataracts","authors":"Jian Zeng, Zonghan Zhou","doi":"10.37290/ctnr2641-452x.21:454-460","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:454-460","url":null,"abstract":"Cistanche is known to relieve cataracts; however, the active ingredients and mechanism of action of cistanche to relieve cataracts are unclear. At present, the active ingredients of cistanche were screened through the Traditional Chinese Medicine Systems Pharmacology website, and a total of six active ingredients were identified. Drug and disease targets were obtained through Swiss target prediction and the Genecard website, and a total of 172 common targets were identified. The biological functions and Kyoto Encyclopedia of Genes and Genomes pathway enrichment of the targets were found to be concentrated in the phosphatidylinositol 3-kinase/protein kinase B, forkhead family of transcription factors, and mitogen-activated protein kinases pathways. The protein–protein interaction network was established, and phosphatidylinositol 3-kinase and protein kinase B-related genes were found to be the key genes. Molecular docking was carried out between the active ingredient and the key target, and it was found that the combination of the active ingredient and the key target was stable. In summary, cistanche can reduce cataracts by regulating the key targets of the active ingredients and thus alleviating cataracts.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Parenteral Nutrition Support and Neoadjuvant Chemotherapy Combined with Cytoreductive Surgery Improve the Quality of Life, but Not the Survival Rate or Incidence of Complications 术后肠外营养支持和新辅助化疗与细胞修复手术相结合可提高生活质量，但不能提高存活率或并发症发生率

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-13 DOI: 10.37290/ctnr2641-452x.21:395-399

Weiwei Song, Dandan Zhu, Yinling Zhao

{"title":"Postoperative Parenteral Nutrition Support and Neoadjuvant Chemotherapy Combined with Cytoreductive Surgery Improve the Quality of Life, but Not the Survival Rate or Incidence of Complications","authors":"Weiwei Song, Dandan Zhu, Yinling Zhao","doi":"10.37290/ctnr2641-452x.21:395-399","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:395-399","url":null,"abstract":"We have explored the efficacy of neoadjuvant chemotherapy in association with cytoreductive surgery and postoperative parenteral nutrition support in advanced ovarian cancer patients. The control group received cytoreductive surgery combined with postoperative conventional chemotherapy and fasted after surgery, whereas the treatment group received neoadjuvant chemotherapy combined with cytoreductive surgery and parenteral nutrition. In contrast to the control group, the operation time, hospital stay, amount of intraoperative blood loss, and abdominal fluid accumulation of the treatment group were diminished, the total effectiveness rate was elevated, serum levels of albumin, transferrin, and prealbumin were increased, levels of human epididymal protein 4, vascular endothelial growth factor, and carbohydrate antigen 125 were declined, and the Karnofky Performance Status score was higher. While there was no difference observed in the 1-year survival rate or total incidence of complications between the two groups, the quality of life of patients in the treatment group improved.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139359917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ginseng Oral Liquid Enhances Therapeutic Output of Rotigotin Patch Plus Amantadine in Parkinson’s Disease 人参口服液可提高罗替戈汀贴剂加金刚烷胺对帕金森病的治疗效果

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-11 DOI: 10.37290/ctnr2641-452x.21:411-416

Lei Hu, Chenhao Zhang, Hailin Dai, Chunliang Zhang, Yuejun Yang, Nan Wang, Fengli Zhao

引用次数: 0

Effect of Early Postoperative Nutritional Nursing on the Prognosis of Patients Undergoing Gastrointestinal Surgery 术后早期营养护理对胃肠道手术患者预后的影响

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-10 DOI: 10.37290/ctnr2641-452x.21:490-494

Hui Shi, Shanshan Li

{"title":"Effect of Early Postoperative Nutritional Nursing on the Prognosis of Patients Undergoing Gastrointestinal Surgery","authors":"Hui Shi, Shanshan Li","doi":"10.37290/ctnr2641-452x.21:490-494","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:490-494","url":null,"abstract":"We have examined the influence of early postoperative nutritional nursing on the prognosis of patients undergoing gastrointestinal surgery. A total of 82 patients with gastrointestinal surgery were recruited from the First Affiliated Hospital of Soochow University between January 2020 and December 2022 for this study. The patients were divided into two equalsized control and treatment groups. The control group received routine care, whereas the treatment group received added nutritional care. Compared to the control group, the first exhaust time, first defecation time, and hospitalization time in the treatment group were shorter (P < 0.01). On the 7th day after surgery, no difference was found in the levels of albumin and total protein between the two groups (P > 0.05). However, on the 4th and 7th days after surgery, the diamine oxidase and malondialdehyde values in the treatment group were lower relative to the control group. Body weight in the treatment group was higher, the incidence of complications was lower, and the quality-of-life score and immune function were better compared to the control group (P < 0.05). To sum up, early nutritional care is beneficial to improving the immune function indexes, nutritional indexes, and quality of life of patients after gastrointestinal surgery, as well as reducing the occurrence of postoperative adverse reactions.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139360675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Puerarin Combined with Nicorandil is More Effective in Treating Coronary Heart Disease and Angina Pectoris 葛根素联合尼可地尔治疗冠心病、心绞痛更有效

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-07 DOI: 10.37290/ctnr2641-452x.21:222-227

Yan Sun, Yuxia Zhao, Yulong Liu, Zilang Yu, Fanrong Wu

{"title":"Puerarin Combined with Nicorandil is More Effective in Treating Coronary Heart Disease and Angina Pectoris","authors":"Yan Sun, Yuxia Zhao, Yulong Liu, Zilang Yu, Fanrong Wu","doi":"10.37290/ctnr2641-452x.21:222-227","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:222-227","url":null,"abstract":"Patients with coronary heart disease and angina pectoris were divided into two groups (control and treatment) of 54 patients per group. The control group received puerarin, whereas the treatment group received puerarin plus nicorandil. Therapeutic outcomes of two treatments were compared by assessing lower left ventricular end systolic diameter, lower left ventricular end diastolic diameter, higher left ventricular ejection fraction, duration of angina pectoris, number of angina attacks, dosage of nitroglycerin needed, plasma viscosity, whole blood viscosity, fibrinogen level, pro-inflammatory markers, as well as 36-item Short Form Survey scores. The total therapeutic rate was better in the group receiving both puerarin and nicorandil than puerarin alone. No difference was discovered in the incidence of adverse reactions between the two groups. This led us to conclude that puerarin combined with nicorandil is more effective in treating coronary heart disease and angina pectoris and can improve cardiac functions, lessen chemodynamic indexes and inflammatory reactions of angina pectoris, and promote the quality of life of patients.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69758093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Simultaneous Intake of Medium-Chain Triglyceride and d-Allulose on Body Fat Accumulation in Rats Fed a High-Fat Diet 同时摄入中链甘油三酯和d-Allulose对高脂饮食大鼠体脂积累的影响

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-07 DOI: 10.37290/ctnr2641-452x.21:242-247

T. Matsuo, C. Yokoyama, Takako Yamada, T. Iida, S. Mochizuki, A. Yoshihara, K. Akimitsu

{"title":"Effect of Simultaneous Intake of Medium-Chain Triglyceride and d-Allulose on Body Fat Accumulation in Rats Fed a High-Fat Diet","authors":"T. Matsuo, C. Yokoyama, Takako Yamada, T. Iida, S. Mochizuki, A. Yoshihara, K. Akimitsu","doi":"10.37290/ctnr2641-452x.21:242-247","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:242-247","url":null,"abstract":"Medium-chain triglycerides, lipids containing three 6−12 carbon medium-chain fatty acids, have antiobesity effects because they do not promote lipogenesis. d-Allulose, a low-calorie epimer of fructose commercially used as a low-calorie sweetener, suppresses hepatic lipogenesis and enhances postprandial fat oxidation. Therefore, we have explored whether a simultaneous intake of medium-chain fatty acids and d-allulose may exhibit a greater reduction in de novo lipogenesis and increase their antiobesity effects. To this end, 32 male Wistar rats were divided into four treatment groups of equal sizes: control, 3% d-allulose-treated, 5% medium-chain triglycerides-treated, and 3% d-allulose + 5% medium-chain triglycerides-treated. After 8 weeks of ad libitum exposure to these diets, d-allulose significantly decreased intra-abdominal adipose tissue and total body fat weight, with or without medium-chain triglyceride supplementation. The antiobesity effect of d-allulose was observed with or without dietary medium-chain triglyceride supplementation in high-fat diet-induced obese rats, but no synergistic effect was detected between d-allulose and medium-chain triglycerides.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69758107","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amarogentin Inhibits Tumor Stem Cell-Like Features of Lung Cancer by Regulating Notch Signaling 紫红素通过调节Notch信号抑制肺癌的肿瘤干细胞样特征

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-07 DOI: 10.37290/ctnr2641-452x.21:215-221

Xiang-qin Wen, Xiaojin Yang

引用次数: 0

The Effects of 12-Week Hydrogen-Rich Water Intake on Body Composition, Short-Chain Fatty Acids Turnover, and Brain Metabolism in Overweight Adults: A Randomized Controlled Trial 12周富氢水摄入对超重成人身体组成、短链脂肪酸转换和脑代谢的影响:一项随机对照试验

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-07 DOI: 10.37290/ctnr2641-452x.21:235-241

D. Korovljev, Dejan Javorac, N. Todorovic, Marijana Ranisavljev, D. Engeset, Tonje Holte Stea, J. Ostojić, Katarina Bijelić, Branislava Srdjenović Čonić, N. Kladar, L. Rátgéber, Nenad Trunić, Sava Rajkovic, V. Štajer, S. Ostojić

{"title":"The Effects of 12-Week Hydrogen-Rich Water Intake on Body Composition, Short-Chain Fatty Acids Turnover, and Brain Metabolism in Overweight Adults: A Randomized Controlled Trial","authors":"D. Korovljev, Dejan Javorac, N. Todorovic, Marijana Ranisavljev, D. Engeset, Tonje Holte Stea, J. Ostojić, Katarina Bijelić, Branislava Srdjenović Čonić, N. Kladar, L. Rátgéber, Nenad Trunić, Sava Rajkovic, V. Štajer, S. Ostojić","doi":"10.37290/ctnr2641-452x.21:235-241","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:235-241","url":null,"abstract":"The aim of this randomized controlled trial was to analyze the effects of medium-term supplementation with hydrogen-rich water on brain metabolism, appetite-regulating hormones, body composition, and safety biomarkers in overweight adults. Twenty (n = 20, 10 females) apparently healthy adults with a body mass index >24.9 kg/m2 were assigned to receive 0.5 L per day of hydrogen-rich water (7.5 mg of hydrogen) or hydrogen-free water (tap water) for 12 weeks. Two-way analysis of variance with repeated measures revealed a significant difference between the two interventions in several body composition indices (P ≤ 0.05), with hydrogen-rich water superior to placebo to reduce waist circumference and mid-upper arm circumference by 1.31 cm (95% confidence interval, from –0.23 to 2.85) and 0.65 cm (95% confidence interval, from –0.10 to 1.40), respectively. Hydrogen-rich water outcompeted placebo to raise serum ghrelin levels, as the mean difference from the placebo group was 17.28 pmol/L (95% confidence interval, from 1.81 to 32.75) (P = 0.02). A non-significant strong positive trend (P = 0.10) was reported toward hydrogen-rich water being superior to placebo in augmenting total serum short-chain fatty acid levels, with a mean difference from the control group of 195.6 μmol/L (95% confidence interval, from –64.55 to 275.85). The mean fecal calprotectin levels were significantly reduced after hydrogen-rich water intervention for 19.7 μg/mg (95% confidence interval, from 0.31 to 39.09) (P = 0.03). Our findings advance hydrogen-rich water as a promising metabolic intervention in overweight adults, but further validation via multicentric longitudinal randomized controlled trials in metabolic and nutritional disorders is required.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48793610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bifidobacterium Triple Viable Granules Combined with Montmorillonite Powder in the Therapy of Children with Diarrhea 双歧杆菌三联活颗粒联合蒙脱石散治疗小儿腹泻

IF 0.5 4区医学

Current Topics in Nutraceutical Research Pub Date : 2023-07-07 DOI: 10.37290/ctnr2641-452x.21:272-276

Wendi Jin, Er-te Yu, Yunbing Lu, Zhaolin Wang, Li Huang, X. Qiao

{"title":"Bifidobacterium Triple Viable Granules Combined with Montmorillonite Powder in the Therapy of Children with Diarrhea","authors":"Wendi Jin, Er-te Yu, Yunbing Lu, Zhaolin Wang, Li Huang, X. Qiao","doi":"10.37290/ctnr2641-452x.21:272-276","DOIUrl":"https://doi.org/10.37290/ctnr2641-452x.21:272-276","url":null,"abstract":"This study was designed to evaluate the effect of Bifidobacterium triple viable granules combined with montmorillonite powder in children with diarrhea. To this end, 60 children with diarrhea were divided into two groups of equal size, with one receiving montmorillonite powder alone (control) and the other receiving montmorillonite powder plus Bifidobacterium triple viable granules (treatment). The children in the treatment group experienced significantly higher overall relief from diarrhea that was associated with shorter durations of fever, diarrhea, abdominal pain, and vomiting, as well as shorter recovery times for stool characters and stool frequency. Also, the serum levels of C-reactive protein, Interleukin-4, and Interleukin-6 were lower, while Immunoglobulin A, Immunoglobulin G, and Immunoglobulin M levels were higher in the treatment group than the control group (P < 0.05). There were far fewer adverse reactions in the treatment group than in the control group. In summary, Bifidobacterium triple viable granules combined with montmorillonite powder are clinically superior in treating children with diarrhea.","PeriodicalId":10976,"journal":{"name":"Current Topics in Nutraceutical Research","volume":null,"pages":null},"PeriodicalIF":0.5,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42403007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0