Optimizing Biosynthesis of Nicotinamide Mononucleotide, a Potential Nutritional Supplement, by E. coli

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-05-05 DOI:10.37290/ctnr2641-452x.21:198-207

Yujuan Cao, Lun Cui

引用次数: 0

Abstract

Nicotinamide mononucleotide plays a crucial role in the biosynthesis of the coenzyme nicotinamide adenine dinucleotide, which is involved in various metabolic pathways in all living organisms. Nicotinamide mononucleotide has recently received attention for its potential health benefits in aging, weight loss, diabetes, and as a neuroprotectant. In this study, we aimed to optimize the production of nicotinamide mononucleotide in E. coli with combinations of genes and plasmids. Our results show that nicotinamide mononucleotide production in Escherichia coli is highly related to bacterial growth rate, indicating that the highest nicotinamide mononucleotide production can be achieved by strains with moderate growth rates. This finding highlights the importance of maintaining a balanced growth rate to achieve optimal nicotinamide mononucleotide production in E. coli. Our study provides insights into optimizing the in vivo synthesis of nicotinamide mononucleotide, a potential agent for nutritional supplementation for novel therapies in various age-related diseases.

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大肠杆菌优化潜在营养补充剂烟酰胺单核苷酸的生物合成

烟酰胺单核苷酸在辅酶烟酰胺腺嘌呤二核苷酸的生物合成中起着至关重要的作用，该二核苷酸参与所有生物体的各种代谢途径。烟酰胺单核苷酸最近因其在衰老、减肥、糖尿病和神经保护方面的潜在健康益处而受到关注。在本研究中，我们旨在通过基因和质粒的组合优化大肠杆菌中烟酰胺单核苷酸的生产。我们的研究结果表明，大肠杆菌中烟酰胺单核苷酸的产生与细菌生长速率高度相关，这表明中等生长速率的菌株可以实现最高的烟酰胺单核苷酸产量。这一发现强调了在大肠杆菌中保持平衡生长速率以实现最佳烟酰胺单核苷酸生产的重要性。我们的研究为优化烟酰胺单核苷酸的体内合成提供了见解，烟酰胺单核苷酸是一种潜在的营养补充剂，可用于各种年龄相关疾病的新疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.