肠内营养和肠外营养相结合更有利于恶性阻塞性黄疸患者的术后预后

IF 0.4 4区医学 Q4 NUTRITION & DIETETICS

Current Topics in Nutraceutical Research Pub Date : 2023-07-06 DOI:10.37290/ctnr2641-452x.21:400-404

Fang Liu, Chuang Yang, Caixia Hou, Yun Ai, Yuqin Chen

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引用次数: 0

摘要

本研究招募了2020年9月至2022年6月期间川北医学院附属医院收治的120名患者，接受经皮经肝胆管引流术。对照组患者接受肠外营养支持，治疗组患者接受肠外和肠内联合营养支持。与对照组相比，治疗组患者首次排气和排便的时间更快，术后活动时间和住院时间更短。两组患者的血清白蛋白和前白蛋白水平均在术后第 1 天下降，第 7 天恢复，治疗组的水平更高。术后，治疗组的丙氨酸氨基转移酶、天门冬氨酸氨基转移酶、总胆红素和直接胆红素水平下降幅度更大。两组的 CD4+、CD8+ 水平和 CD4+/CD8+ 比值均升高，治疗组的水平更高。与对照组相比，治疗组的并发症发生率较低。综上所述，对术后恶性梗阻性黄疸患者进行肠内肠外联合营养支持，可促进胃肠道功能更快恢复，改善营养状况，促进肝功能恢复，促进免疫功能。

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A Combination of Enteral and Parenteral Nutrition Better Supports Postoperative Prognosis of Patients with Malignant Obstructive Jaundice

A total of 120 patients admitted to affiliated hospitals of the North Sichuan Medical College between September 2020 and June 2022 were recruited for this study and received percutaneous transhepatic cholangial drainage. Patients in the control group received parenteral nutrition support, whereas patients in the treatment group received parenteral and combined enteral nutrition support. Compared to the control group, the time of first exhaustion and defecation in the treatment group was faster, and the postoperative activity time and hospital stay were shorter. Serum albumin and prealbumin levels in both groups decreased on the 1st day after surgery and recovered on the 7th day, with the treatment group reaching higher levels. After surgery, the decline in alanine aminotransferase, aspartate aminotransferase, total bilirubin, and direct bilirubin levels was higher in the treatment group. CD4+, CD8+ levels, and CD4+/CD8+ ratios in both groups were elevated, with the treatment group showing higher levels. The occurrence of complications in the treatment group was lessened relative to the control group. In summary, enteral combined parenteral nutrition support for patients with malignant obstructive jaundice after surgery can promote faster recovery of gastrointestinal function, improve nutritional status, facilitate the recovery of liver function, and promote immune function.

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来源期刊

Current Topics in Nutraceutical Research 医学-药学

CiteScore

1.10

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： Current Topics in Nutraceutical Research is an international, interdisciplinary broad-based peer reviewed scientific journal for critical evaluation of research on chemistry, biology and therapeutic applications of nutraceuticals and functional foods. The major goal of this journal is to provide peer reviewed unbiased scientific data to the decision makers in the nutraceutical and food industry to help make informed choices about development of new products. To this end, the journal will publish two types of review articles. First, a review of preclinical research data coming largely from animal, cell culture and other experimental models. Such data will provide basis for future product development and/or human research initiatives. Second, a critical evaluation of current human experimental data to help market and deliver the product for medically proven use. This journal will also serve as a forum for nutritionists, internists, neurologists, psychiatrists, and all those interested in preventive medicine. The common denominator of all of the topic to be covered by the journal must include nutraceuticals and/functional food. The following is an example of some specific areas that may be of interest to the journal. i) Role of vitamins, minerals, antioxidants and phytonutrients on cardiovascular health, cancer, diabetes, ocular health, mental health, men’s health, women’s health, infant nutrition, ii) Role of herbals on human health, iii) Dietary supplements and sleep, iv) Components of diet that may have beneficial effect on human health, v) regulation of apoptosis and cell viability, vi) Isolation and characterization of bioactive components from functional foods, vii) Nutritional genomics, and viii) Nutritional proteomics.