Current Nanoscience最新文献

{"title":"Strategy for Targeting Medical Diagnosis of Cerebral Ischemia Regions by Linking Gsk-3β Antibody and RVG29 to Magnetosomes","authors":"Qing Wang, Xianyu Li","doi":"10.2174/0115734137259242231109174821","DOIUrl":"https://doi.org/10.2174/0115734137259242231109174821","url":null,"abstract":"Background: In our previous studies, we have identified Gsk-3β as a crucial target molecule in response to Danhong injection for cerebral ischemia intervention. Furthermore, it can serve as a molecular imaging probe for medical diagnosis. Bacterial magnetic particles (BMPs), synthesized by magnetotactic bacteria, are regarded as excellent natural nanocarriers. Methods: In this study, we utilized biological modification and chemical crosslinking techniques to produce a multifunctional BMP known as \"RVG29-BMP-FA-Gsk-3β-Ab\", which exhibits both magnetic properties and brain-targeting capabilities. Then, a combination of analytical techniques was used to characterize the properties of the multifunctional BMPs. Finally, we evaluated the cell targeting ability of the RVG29-BMP-FA-Gsk-3β-Ab. Results: The multifunctional BMPs were observed to possess uniform size and shape using TEM analysis, with a particle size of 70.1±7.33 nm. Zeta potential analysis revealed that the nanoparticles exhibited a regular and non-aggregative distribution of particle sizes. Relative fluorescence intensity results demonstrated that the complex of 1mg of RVG29-BMP-FA-Gsk- 3β-Ab could bind to FITC-RVG29 polypeptide at a concentration of 2189.5 nM. Cell viability analysis indicated its high biocompatibility and minimal cytotoxicity. The RVG29-BMP-FAGsk- 3β-Ab was observed to possess active targeting towards neuronal cells and fluorescence imaging capabilities in vitro, as evidenced by fluorescence imaging assays. The complex of RVG29-BMP-FA-Gsk-3β-Ab exhibited favourable properties for early diagnosis and efficacy evaluation of traditional Chinese medicine in treating cerebral ischemia. Conclusion: This study establishes a fundamental basis for the prospective implementation of multimodal imaging in traditional Chinese medicine for cerebral ischemia.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"27 1","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138538992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Green Nanomaterials for Clean and Sustainable Environment","authors":"R. Chaudhary, Sami Mahmood, R. Jotania","doi":"10.2174/157341371906230511103527","DOIUrl":"https://doi.org/10.2174/157341371906230511103527","url":null,"abstract":"<jats:sec>\u0000<jats:title />\u0000<jats:p />\u0000</jats:sec>","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":" ","pages":""},"PeriodicalIF":1.5,"publicationDate":"2023-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47633754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polymersomes as Next Generation Nanocarriers for Drug Delivery: Recent Advances, Patents, Synthesis and Characterization","authors":"Surya Goel, Ruchi Singh, Megha Tonk","doi":"10.2174/0115734137271094231101062844","DOIUrl":"https://doi.org/10.2174/0115734137271094231101062844","url":null,"abstract":"Background: Polymersomes (PS), self-assembled nanostructures formed by amphiphilic block copolymers, have garnered significant attention in recent years due to their unique properties and versatile applications in the fields of drug delivery and biomedicine. They are being prepared for a wide range of complex medicinal compounds, including nucleic acids, proteins, and enzymes. Polymersomes have lately been used as vehicles for delivering varied therapeutic substances and regulating ROS (reactive oxygen species). Due to their immunogenic features, polymersomes could play a critical role in enhancing subunit vaccine and drug delivery against COVID-19 infection. Objective: The prime purpose of this manuscript is to furnish an extensive overview of polymersomes, highlighting their recent advances, fabrication methods, characterization techniques, and pharmaceutical applications. Methods: The article has been amassed using several online and offline manuscripts from reputed journals, books, and other resources. Besides this, various user-friendly interfaces, like Pubmed, Google Scholar, etc, have been utilized to gather the latest data about polymersomes. This domain encompasses recent advancements in the realm of innovations about the delivery of drugs through polymeric vesicles. This field involves innovations or developments in nanocarrier systems as they are efficaciously employed to deliver the desired moiety to the targeted site. Results: PS have been discovered to exhibit remarkable promise in addressing various challenges associated with inadequate bioavailability, targeted drug delivery, dosing frequency, and diminished toxic effects. Over the past decade, such nanovesicles have been effectively employed as a complementary approach to address the issues arising from poorly soluble medications. However, this domain still requires further focus on novel breakthroughs. Conclusion: Polymersomes demonstrate unparalleled potential as innovative carriers, exhibiting remarkable versatility and exceptional biocompatibility. This concise review underscores their extraordinary prospects in diverse fields, accentuating their distinctive attributes and opening new avenues for groundbreaking applications.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"72 10","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135545020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgements to Reviewers","authors":"Yuri Agrawal, Teodoro S. Kaufman, Smrithi Padmakumar, Deepthy Menon, Carlos M.R. Sant'Anna, Gurudeeban Selvaraj Satyavani Kaliamurthi, Dong-Qing Wei, Darakhshan Jabeen Haleem, Hang Cao, Xuejun Li , Feiyifan Wang, Yueqi Zhang, Yi Xiong, Qi Yang","doi":"10.2174/157341371906230511122153","DOIUrl":"https://doi.org/10.2174/157341371906230511122153","url":null,"abstract":"","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"46 18","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136103378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meet the Editorial Board Member","authors":"Xiaosheng Fang","doi":"10.2174/157341371906230511103259","DOIUrl":"https://doi.org/10.2174/157341371906230511103259","url":null,"abstract":"","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"367 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136102770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Coalescence of Au Nanoparticles in Silica Aerogel under Electron Beam Irradiation","authors":"Heena Sammi, Neha Sardana, Manish Mohanta, Bhagwati Sharma","doi":"10.2174/1573413719666221122123805","DOIUrl":"https://doi.org/10.2174/1573413719666221122123805","url":null,"abstract":"Background: The coalescence of Au nanoparticles embedded in the silica gel matrix was observed by E-beam irradiation in a transmission electron microscope. Methods: It was examined that interparticle spacing between nanoparticles was reduced after incorporation into the matrix and particles came close to each other. TEM studies have shown that during E-beam irradiation ~13 nm Au nanoparticles contacted with each other along with the shrinkage of the silica aerogel or as well as the removal of surfactant layer, and transformed into different shapes of particles such as dumbbell and chain-like particles as per the interparticle gap. Results: This nanoparticle-aerogel matrix has the potential for applications in sensing, nonlinear optics, and catalysis. Conclusion: This work enhances the understanding of the role of silica aerogel and E-beam irradiation in directing the coalescence of nanoparticles.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"256 ","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136103078","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Biomimetic Cilia Microrobots: Driving Methods, Application and Research Prospects","authors":"Ziang Jing, Gaoshen Cai, Yufeng Pan, Yongfeng Yuan","doi":"10.2174/0115734137268436231023071009","DOIUrl":"https://doi.org/10.2174/0115734137268436231023071009","url":null,"abstract":"Abstract: With the development of science and technology, microrobots have been used in medicine, biology, rescue, and many other fields. However, the microrobots have problems such as energy and motion due to miniaturization. In order to solve the problem of the energy supply of microrobots, researchers have provided more drive schemes for microrobots. Inspired by the biological cilia, the biomimetic cilia have been developed and applied to microrobots to achieve propulsion, liquid pumping, liquid mixing, and particle manipulation. This review summarizes the different driving modes of microrobots, focusing on the application of magnetic drive and optical drive in the field of micro-robots. The structure and function of biological cilia and biomimetic cilia are introduced. The application of biomimetic cilia microrobots in various fields is discussed, and the current challenges and future development trends of biomimetic cilia microrobots are summarized. This review hopes to provide useful help for researchers of biomimetic cilia microrobots","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135928536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Review on Nano/Microfluidic Devices for Cell Isolation Techniques: Recent Progress and Advances","authors":"Hamid Reza Garshasbi, Seyed Morteza Naghib","doi":"10.2174/0115734137264742231001142853","DOIUrl":"https://doi.org/10.2174/0115734137264742231001142853","url":null,"abstract":"Abstract: Micro/nanofluidic devices and systems have gained increasing interest in healthcare applications over the last few decades because of their low cost and ease of customization, with only a small volume of sample fluid required. Many biological queries are now being addressed using various types of single-molecule research. With this rapid rise, the disadvantages of these methods are also becoming obvious. Micro/nanofluidics-based biochemical analysis outperforms traditional approaches in terms of sample volume, turnaround time, ease of operation, and processing efficiency. A complex and multifunctional micro/nanofluidic platform may be used for single-cell manipulation, treatment, detection, and sequencing. We present an overview of the current advances in micro/nanofluidic technology for single-cell research, focusing on cell capture, treatment, and biochemical analyses. The promise of single-cell analysis using micro/nanofluidics is also highlighted.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135619495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NBTI Effect Survey for Low Power Systems in Ultra-nanoregime","authors":"None Kajal, Vijay Kumar Sharma","doi":"10.2174/0115734137252023230919054547","DOIUrl":"https://doi.org/10.2174/0115734137252023230919054547","url":null,"abstract":"Background: Electronic device scaling with the advancement of technology nodes maintains the performance of the logic circuits with area benefit. Metal oxide semiconductor (MOS) devices are the fundamental blocks for building logic circuits. Area minimization with higher efficiency of the circuits motivates the researchers of very large-scale integration (VLSI) design. Moreover, the reliability of digital circuits is one of the biggest challenges in VLSI technology. A major issue in reliability is negative bias temperature instability (NBTI) degradation. NBTI affects the efficiency and reliability of electronic devices. Method: This paper presents a review of NBTI physical-based mechanisms. NBTI's impact on VLSI circuits and techniques has been studied to mitigate and compensate for the effect of NBTI. Result: This review paper presents an idea to relate the NBTI and leakage mitigation techniques. This study gives an overview of the efficiency, complexity, and overhead of NBTI mitigation techniques and methodologies. Conclusion: This survey provides a brief idea about NBTI degradation by using reliability simulation. Moreover, the extensive aging effect is discussed in the paper.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136015610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Progress in the Composites of Perovskite Nanocrystals and II-VI Quantum Dots: Their Synthesis, Applications, and Prospects","authors":"Qiaoyun Wu, Rongrong Hu, Bobo Yang, Wenfang Peng, Mingming Shi, Yuefeng Li, Lin Cheng, Pan Liang, Jun Zou","doi":"10.2174/0115734137269553230919171016","DOIUrl":"https://doi.org/10.2174/0115734137269553230919171016","url":null,"abstract":"The remarkable photoelectric characteristics of perovskite nanocrystals (NCs), including high fault tolerance, tunable photoluminescence (PL) emission, and high carrier mobility, contribute to making them especially attractive for photonic and optoelectronic applications. Unfortunately, the poor environmental thermal and light stability set obstacles to their industrial applications. Over the past 40 years, II-VI semiconductor quantum dots (QDs) have achieved many important photophysics findings and optoelectronic applications. Compared with perovskite NCs, II-VI semiconductor QDs still have a relatively weaker molar absorbance coefficient. Whereas, significant enhancement of both the stability and the optical performance of the composites of perovskite NCs and II-VI QDs are of interest for photovoltaic and optoelectronic devices. The composites of perovskite NCs and II-VI QDs come in two primary types: core/shell structures and heterojunction structures. To better understand the composites of perovskite NCs and II-VI QDs, the approaches of synthesis methods, their optoelectronic properties, carrier dynamics and potential applications in solar cells, light emitting diodes (LEDs) and photodetectors are summarized. Furthermore, the unmet problems and the potential applications are also presented.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136361063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}