A Review on Nano/Microfluidic Devices for Cell Isolation Techniques: Recent Progress and Advances

IF 1.4 4区材料科学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Current Nanoscience Pub Date : 2023-10-20 DOI:10.2174/0115734137264742231001142853

Hamid Reza Garshasbi, Seyed Morteza Naghib

引用次数: 0

Abstract

Abstract: Micro/nanofluidic devices and systems have gained increasing interest in healthcare applications over the last few decades because of their low cost and ease of customization, with only a small volume of sample fluid required. Many biological queries are now being addressed using various types of single-molecule research. With this rapid rise, the disadvantages of these methods are also becoming obvious. Micro/nanofluidics-based biochemical analysis outperforms traditional approaches in terms of sample volume, turnaround time, ease of operation, and processing efficiency. A complex and multifunctional micro/nanofluidic platform may be used for single-cell manipulation, treatment, detection, and sequencing. We present an overview of the current advances in micro/nanofluidic technology for single-cell research, focusing on cell capture, treatment, and biochemical analyses. The promise of single-cell analysis using micro/nanofluidics is also highlighted.

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纳米/微流体细胞分离装置的研究进展

摘要:在过去的几十年里，微/纳米流体器件和系统由于其低成本和易于定制，只需要少量的样品流体，在医疗保健应用中获得了越来越多的兴趣。许多生物学问题现在正在使用各种类型的单分子研究来解决。随着这种快速增长，这些方法的缺点也变得明显。基于微/纳米流体的生化分析在样本量、周转时间、操作便捷性和处理效率方面优于传统方法。复杂的多功能微/纳米流体平台可用于单细胞操作、处理、检测和测序。我们概述了目前用于单细胞研究的微/纳米流体技术的进展，重点是细胞捕获、处理和生化分析。利用微/纳米流体进行单细胞分析的前景也得到了强调。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Nanoscience 工程技术-材料科学：综合

CiteScore

3.50

自引率

6.70%

发文量

审稿时长

4.4 months

期刊介绍： Current Nanoscience publishes (a) Authoritative/Mini Reviews, and (b) Original Research and Highlights written by experts covering the most recent advances in nanoscience and nanotechnology. All aspects of the field are represented including nano-structures, nano-bubbles, nano-droplets and nanofluids. Applications of nanoscience in physics, material science, chemistry, synthesis, environmental science, electronics, biomedical nanotechnology, biomedical engineering, biotechnology, medicine and pharmaceuticals are also covered. The journal is essential to all researches involved in nanoscience and its applied and fundamental areas of science, chemistry, physics, material science, engineering and medicine. Current Nanoscience also welcomes submissions on the following topics of Nanoscience and Nanotechnology: Nanoelectronics and photonics Advanced Nanomaterials Nanofabrication and measurement Nanobiotechnology and nanomedicine Nanotechnology for energy Sensors and actuator Computational nanoscience and technology.