Current Nanoscience最新文献

{"title":"A Comprehensive Review on Co-Crystals: Transforming Drug Delivery with Enhanced Solubility and Bioavailability","authors":"Sharad Sharma, Malkiet Kaur, Manju Nagpal","doi":"10.2174/0115734137305307240815065424","DOIUrl":"https://doi.org/10.2174/0115734137305307240815065424","url":null,"abstract":"Poor solubility and bioavailability of various drug compounds are the biggest challenges faced by researchers and industrialists, hindering their therapeutic efficacy. Researchers have developed a versatile approach to enhance the solubility and bioavailability of the drug i.e., co-crystallization. Pharmaceutical co-crystals are solid, crystalline materials consisting of API and co-formers that have supramolecular chemistry with one another. Co-crystallization helps in enhancing a drug’s physico-chemical properties, such as bioavailability, solubility and dissolution, preserving its therapeutic effect. The API and co-former in co-crystals are bound to each other via hydrogen bonding, π-stacking, and Van der Waals forces. Several methods to prepare co-crystals, such as solvent evaporation method, grinding method, cooling crystallization method, etc, and various research reports, including all the methods of preparation are discussed in this review article. Conventional marketed products and patents on co-crystals are also included. Data has been gathered, and relevant literature reports have been examined utilizing a variety of search engines, including Google Scholar, ScienceDirect, Pubmed, and Google patents. After reviewing the literature, the researchers found that the cocrystallization method is one the simplest method to enhance drug bioavailability and solubility. Moreover, it enhances the pharmacokinetics parameters, pharmacodynamics properties, and melting point of the drug. In this review article, the researchers have compiled the recent literature reports on enhanced drug solubility via co-crystallization method. The researchers concluded that this review article can help other researchers by providing them with recent literature on this article and can compare the various methods of enhancing drug solubility and bioavailability. It also consists of compiled data of patents and marketed formulations prepared by the co-crystallization technique. Thus, co-crystallization could be established as a versatile approach for enhancing drug solubility and bioavailability.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent Advances of the Ultimate Microbial Influenced Corrosion (MIC): A Review","authors":"Yasin Albarqouni, Gomaa Sanad, Kwok Feng Chong, Nurul Huda Abu Bakar, Randa Althubaiti, Arman Abdullah","doi":"10.2174/0115734137318645240820052805","DOIUrl":"https://doi.org/10.2174/0115734137318645240820052805","url":null,"abstract":": The persistent corrosion of metal surfaces poses a significant engineering challenge, including material degradation, loss of metal-structural integrity, and massive maintenance costs in various industrial, medical, and aerospace applications. Microorganisms such as archaea, bacteria, fungi, and microalgae can directly or indirectly influence metal corrosion. The degree of corrosiveness and corrosion healing varies depending on the microbe, medium, and metal substrate characteristics. Several attempts have been made to reveal answers to all questions about MIC. The published reports focused on testimonial failures and laboratory or field tests under varied situations. This review offers an overview of the most recent MIC research and emphasizes the scarcity of data on MIC detection, estimation, and the most recent approaches for MIC management. The review extends previously reported works and summarizes efforts for better understanding and cutting off MIC management in advanced technologies. Furthermore, it concludes with a final discussion of the current and future drawbacks and protective systems for preventing microbial-induced corrosion.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fabrication of Ti/Zr-SnO2/PbO2-Nd Electrode for Efficient Electrocatalytic Degradation of Alizarine Yellow R","authors":"Jing Zhang, Bi Yang, Guan-Jin Gao, Qing-Dong Miao, Wei-Guo Hu, Jin-Gang Yu","doi":"10.2174/0115734137325822240819050628","DOIUrl":"https://doi.org/10.2174/0115734137325822240819050628","url":null,"abstract":"Introduction: A novel attempt to degrade alizarine yellow R (AYR) by lead dioxide (PbO2)/ neodymium (Nd) coated Ti anode was investigated. Method: Ti/Zr-SnO2/PbO2-Nd electrode showed high oxygen evolution potential, high current density, and neutral conditions, which favored the degradation of AYR. The PbO2-Nd layer on Ti/Zr-SnO2 was further characterized by scanning electron microscopy, and X-ray diffraction analysis, and X-ray photoelectron spectroscopy. The electrochemical properties of Ti/Zr- SnO2/PbO2-Nd electrode were evaluated by cyclic voltammetry, AC impedance spectroscopy, and accelerated life test. Result: The relatively higher oxygen evolution overpotential (~1.80 V) of the developed electrode can effectively suppress the occurrence of surface side reactions and oxygen evolution. A relatively lower charge transfer resistance (Rct, 18.0 Ω) of Ti/Zr-SnO2/PbO2-Nd electrode could be found. The Ti/Zr-SnO2/PbO2-Nd electrode exhibited an accelerated lifetime of 110 min under a very high current density of 10,000 A/m2. The doping of Nd could produce loosely-stacked sheet-like structures, thus, the number of active sites on the electrode surface increases. Conclusion: Moreover, an outstanding conductivity of Ti/Zr-SnO2/PbO2-Nd electrode was obtained, which favored the electron transfer and catalytic activity of the modified electrode. The Ti/Zr-SnO2/PbO2-Nd electrode exhibited improved electrochemical performances and higher oxygen evolution potential, and the highest oxygen evolution potential is 1.80 V. Under the current density of 30 mA/cm2, the electrocatalytic degradation of 92.3% could be achieved in 180 min. The electrochemical oxidation of AYR at the Ti/Zr-SnO2/PbO2-Nd electrode proved to be feasible and effective, indicating that it might be used for the elimination of AYR from wastewater. conclusion: The electrochemical oxidation of AYR at the Ti/Zr-SnO2/PbO2-Nd electrode proved to be feasible and effective, indicating that it might be used for the elimination of AYR from wastewater.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of Silver Nanoparticles Using Haplophyllum robustum Bge. Extract: Antibacterial, Antifungal, and Scolicidal activity against Echinococcus granulosus Protoscolices","authors":"Razih Movahedi, Damoun Razmjoue, Ahmad Movahedpour, Rajender S. Varma, Mahmoud Bahmani","doi":"10.2174/0115734137328566240821090454","DOIUrl":"https://doi.org/10.2174/0115734137328566240821090454","url":null,"abstract":"Background: Silver nanoparticles (AgNPs) biosynthesized via the deployment of plant extractives have garnered much attention, especially due to their antimicrobial properties. Herein, the green synthesis of silver nanoparticles has been accomplished using the aqueous extract of Haplophyllum robustum, which includes a study of its antibacterial, antifungal, and scolicidal activity. Methods: The preparative process was followed by characterization using UV-Vis spectroscopy, and the ensuing spherical AgNPs of average size 7-25 nm were identified by Dynamic Light Scattering (DLS), X-Ray Diffraction (XRD), Fourier Transform Infrared Spectroscopy (FTIR), Scanning Electron Microscopy (SEM), and Transmission Electron Microscopy (TEM). The antibacterial, antifungal, and scolicidal activities of AgNPs were assessed by deploying disc diffusion and microdilution methods against four standard bacteria and four typical Candida species and liver hydatid cyst protoscoleces, where they exhibited good biological activity. Results: The results showed that the greener synthesis of silver nanoparticles using the aqueous extract of renewable and abundant H. robustum plant is a simple, inexpensive, and safer alternative that does not use any toxic or harmful substances. Conclusion: Thus, with minimal or no side effects, this approach to AgNPs bodes well for their appliances as antibacterial, antifungal, and scolicidal agents.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deposition of TiO2/Polymethylene Biguanide on Stainless Steel Wire for the Enhancement of Corrosion Resistance and Stability","authors":"Kiruthigha Thirumal, Gokul Sridharan, Dhanraj Ganapathy, Ashok K. Sundramoorthy","doi":"10.2174/0115734137310115240812071132","DOIUrl":"https://doi.org/10.2174/0115734137310115240812071132","url":null,"abstract":"Background: Orthodontic treatment relies on stainless steel (SS) wires to apply forces and torque to reposition teeth. However, SS wires are susceptible to wear and corrosion in the oral environment, necessitating improvements in their durability. Objective: This study explores the potential of a coating comprising titanium dioxide (TiO2) and polymethylene biguanide (PHMB) to enhance the corrosion resistance of SS wires. Methods: SS wires were coated with a solution containing PHMB and TiO2 using a drop-casting technique. Field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDAX), and electrochemical tests, including impedance spectroscopy and potentiodynamic polarization, were conducted to characterize the coated wires and evaluate their corrosion resistance. Results: FE-SEM, EDAX, and Emap analysis confirmed the presence and uniform deposition of PHMB/TiO2 onto the SS wire surface. Electrochemical tests revealed that the PHMB/TiO2- coated SS wires exhibited a significantly lower corrosion rate (7.08×10−6 mm/year) and higher corrosion resistance (562466 Ω) compared to bare SS. Conclusion: The PHMB/TiO2 coated SS wire exhibited high corrosion resistance and offered potential benefits for orthodontic treatments. Further research and optimization of this coating may help to improve the durability and reliability of orthodontic appliances.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176610","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Advanced Bioceramics: Properties, Fabrication and Applications","authors":"Hanaa. K. Abd El-Hamid","doi":"10.2174/0115734137317518240723112352","DOIUrl":"https://doi.org/10.2174/0115734137317518240723112352","url":null,"abstract":"Bioceramics are engineered materials that achieve their applications in the medical field. Bioceramics are promising inorganic materials to create scaffolds for bone regeneration due to their desirable properties, such as biocompatibility, osteoconduction, and their similarity with bone composition. Bioceramics can operate as tissue replacement and can be used for coating metal implants to increase their biocompatibility. Bioceramics are classified into three types: bioinert ceramics, bioactive bioceramics, and biodegradable ceramics. There are different methods for the fabrication of bioceramics, they can be prepared by conventional powder processing methods or by some new unconventional methods. Bioceramics can be fabricated by a sintering process, which takes place through the hardening of the green bodies at a relatively high temperature lower than their melting point. Nowadays, microwave sintering is excellent in both heating efficiency, saving energy and time, and the concomitant processing cost. There are other methods used to obtain bioceramics; such as sol-gel, gas-foaming, gel-casting, and freeze-casting techniques. Recently, the CAD/CAM technique (computer-aided design/manufacture) was used in the fabrication of bioceramics and is applied in the dentistry field. The application of bioceramics connects to the repair of the skeletal system, which consists of joints, bones, and teeth, as well as both soft and hard tissues. Bioceramics can be used to replace parts of the cardiovascular system, especially heart valves.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142223467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oxidized Ethylene Glycol/ZrO2-coated NiTi Orthodontic Arch Wires: Surface Characterization and Electrochemical and Corrosion Studies","authors":"Abisha Perumal, Gokul Sridharan, Dhanraj Ganapathy, Keerthana Madhivanan, Ashok K. Sundramoorthy","doi":"10.2174/0115734137313324240723073001","DOIUrl":"https://doi.org/10.2174/0115734137313324240723073001","url":null,"abstract":"Background: Orthodontic arch wires, typically made of Nickel Titanium (NiTi), are widely utilized in dental procedures for correcting teeth misalignment and jaw issues due to their favorable mechanical attributes and cost-effectiveness. However, these NiTi wires are prone to corrosion in the oral environment, leading to diminished mechanical stability, compromised aesthetics, and potential health concerns for patients. Objective: There is a growing demand to augment the corrosion resistance and stability of orthodontic wires. Hence, this study aimed to address these issues. Herein, zirconium dioxide (ZrO2) and oxidized ethylene glycol (OEG) films were deposited onto NiTi wires to improve the corrosion resistance and stability. Methods: NiTi wires were modified by a two-step process involving electrodeposition of ZrO2 and oxidized ethylene glycol (OEG) film. The surface characterizations of coated material (OEG/ZrO2/NiTi) were carried out by using Field Emission Scanning Electron Microscopy (FESEM), Energy Dispersive X-ray Spectroscopy (EDS), and Electron Microprobe Analysis (EMap) to confirm the elemental composition of the coated NiTi wire. Results: The OEG/ZrO2/NiTi wire exhibited a potentiodynamic polarization resistance of 547037 Ω and higher stability than the bare NiTi wire (396421 Ω). The corrosion rate for OEG/ZrO2/NiTi wire was found to be 0.040 mm/year, which was comparatively lower than a bare NiTi wire (0.069 mm/year). Due to the formation of OEG/ZrO2 film, NiTi wire became electrically insulative and showed a higher impedance than bare NiTi wire. Conclusion: The bilayer coating of ZrO2 and OEG has proven to significantly improve the corrosion resistance and stability of the wires. Thus, these materials can be considered for coating orthodontic arch wires with improved corrosion stability.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142176612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Progress in Essential Oil Nanodelivery Systems","authors":"Shangdian Wang, Zhiwei Zhou, Songhong Yang, Zilu Guo, Ting Le, Jun Wu, Zhiyu Guan, Wenjun Liu, Wenting Wu","doi":"10.2174/0115734137293979240709113456","DOIUrl":"https://doi.org/10.2174/0115734137293979240709113456","url":null,"abstract":"Essential Oil (EO) is widely usedin medicine because of its antioxidant, antiinflammatory, antibacterial, antimicrobial, and antiviral properties. However, the hydrophobicity, volatility, instability, and potential toxicity of EO make it difficult to achieve efficient delivery in vivo, which limits its application. In recent years, nano drug delivery systems have been gradually applied to encapsulate EO to improve their physical and chemical properties. In order to further improve the delivery efficiency of EOs, this review summarized the commonly used nano delivery systems for EOs, analyzed their preparation principles, and listed the factors affecting the delivery efficiency of essential oils. Moreover, the challenges faced by the EO delivery system are sorted out, and the corresponding solutions are proposed, with the hope of indicating the development direction for expanding the application of the nano drug delivery system in EO.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141779973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Weaving the Future of Topical Medicine: A Journey with Electrospinning Nanofibre Scaffolds","authors":"Ghanshyam Parmar, Jay Mukesh Chudasama, Chintan Aundhia","doi":"10.2174/0115734137311390240630120055","DOIUrl":"https://doi.org/10.2174/0115734137311390240630120055","url":null,"abstract":": The pharmaceutical sciences are gradually shielding mankind from a plethora of deadly but as-of-yet-undiscovered ailments. Many diseases, some of which can be fatal, have their initial line of defence on the skin. A significant challenge for scientists is the development of appropriate pharmacological formulations for transdermal drug administration. Low side effect risk reduces first-pass impact, and good patient compliance makes transdermal distribution superior to oral delivery. This is why transdermal medication delivery is so important. Thanks to advancements in pharmaceutical delivery systems, the skin can now absorb medications more effectively. Researchers from different parts of the globe have investigated many different kinds of medications as possible transdermal delivery routes using electrospinning nanofibres. The skin can more easily absorb therapeutic compounds thanks to the nanofibres' ability to concentrate them. It is possible to load hydrophilic and lipophilic medications onto polymeric nanofibres. Another option is the transdermal distribution of biopolymer nanofibres. Over long periods of time, they control the release of medicinal substances. Nanofibres and nanoparticles allow for the controlled release of both hydrophobic and hydrophilic drugs. Transdermal and topical medication delivery using polymeric electrospinning nanofibres laden with nanoparticles and medicines is the subject of this research review. After that, we'll look at some practical instances of engineers using electrospinning fibres to control the release of drugs in reaction to environmental and internal factors. Afterwards, we will quickly go over the latest developments in tissue engineering, hard tissue engineering [which includes repairing musculoskeletal systems, bones, and cartilage], and cancer therapy that uses electrospin nanofiber scaffolds to control the distribution of drugs. Thanks to recent advancements in medicine and pharmaceuticals, nanofibres may soon be able to transport a wide variety of drugs, allowing for more targeted methods of cellular regeneration and topical medication delivery.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141745101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Effect of Unmodified Gold-platinum Nanoparticles on Gouty Arthritis Via the Nrf2/HO-1 Pathway","authors":"Zirui Liu, Dan Li, Baofeng Zhao, Xifan Mei","doi":"10.2174/0115734137294469240702070418","DOIUrl":"https://doi.org/10.2174/0115734137294469240702070418","url":null,"abstract":"Background: Gouty arthritis, characterized by excruciating pain and discomfort, poses a significant burden on patients. While nanomedicines have shown promise in addressing this ailment, their complicated synthesis processes often involve potentially toxic procedures, contributing to adverse side effects in disease management. Methods: In this study, we introduce a straightforward and elegant solution by utilizing easily prepared gold platinum (AuPt) nanoparticles for the treatment of gouty arthritis. The synthesis of these nanoparticles involves the use of gold and platinum precursors in conjunction with NaBH4, simplifying the manufacturing process. Experimental models of gout were established in both in vivo and in vitro settings through lipopolysaccharide and monosodium urate crystal induction. Results: Our findings revealed that AuPt nanoparticles exhibited potent anti-inflammatory effects against gout. This effect was attributed to their ability to activate the Nrf2/HO-1 pathway, resulting in pain alleviation and the inhibition of inflammation, ultimately leading to the reduction of joint edema. With their uncomplicated synthesis and promising therapeutic potential, these simply prepared AuPt nanoparticles emerge as a compelling candidate for pharmaceutical intervention in the treatment of gouty arthritis. Conclusion: This approach not only holds the promise of delivering effective relief to patients but also minimizes the risk of unwanted side effects associated with complex nanomedicine synthesis processes.","PeriodicalId":10827,"journal":{"name":"Current Nanoscience","volume":null,"pages":null},"PeriodicalIF":1.5,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141745099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}