Current Eye Research最新文献

{"title":"Short-Term Effects of Dark Chocolate on Choroidal Parameters in Myopic Patients During Near Work.","authors":"Meng Lin, Di Ma, Jiahui Shen, Xuzhou Chen, Dexi Zhu, Fan Lu, Liang Hu","doi":"10.1080/02713683.2025.2551167","DOIUrl":"https://doi.org/10.1080/02713683.2025.2551167","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the effects of dark chocolate during relaxation and near work on choroidal thickness and blood flow parameters in myopic patients.</p><p><strong>Methods: </strong>Thirty-one myopic subjects were recruited for this self-controlled study. Participants need to complete two experiments. Experiment 1: Subjects first underwent a 10-minute washout process (0 diopter), followed by 20 min of near work (5 diopter). Experiment 2: After consuming 30 grams of dark chocolate 2 h in advance, subjects underwent the washout and near work procedures. Choroidal parameters were measured using swept-source optical coherence tomography angiography (SS-OCT/OCTA). Parameters comprised mean choroidal thickness (ChT), choriocapillaris perfusion area (CCPA), along with choroidal vessel volume (CVV) and three-dimensional choroidal vascularity index (CVI) quantified specifically for large- and middle-sized vessels.</p><p><strong>Results: </strong>After consuming dark chocolate, ChT and CCPA significantly increased during relaxation in individuals with myopia. Both experiments found that the choroidal blood flow decreased significantly after near work, but the ChT decreased significantly only after consumption of dark chocolate. Furthermore, there were significant differences in the changes of CCPA and CVI between the two experiments.</p><p><strong>Conclusions: </strong>After consumption of dark chocolate for two hours, a positive effect on choroidal thickness and blood flow was observed under relaxed condition. No evidence was found that consumption of dark chocolate could inhibit the reduction in choroidal thickness or blood flow during near work.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-9"},"PeriodicalIF":2.0,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship Between Refractive Parameter and Serum Vascular Endothelial Growth Factor Concentration and Optical Coherence Tomographic Angiography in Myopia Children with Retinopathy of Prematurity.","authors":"Chen Chen, Liu Hong, Xiang Ma","doi":"10.1080/02713683.2025.2503202","DOIUrl":"10.1080/02713683.2025.2503202","url":null,"abstract":"<p><strong>Purpose: </strong>The study aimed to investigate the risk factors contributing to myopia in children after the spontaneous regression of retinopathy of prematurity (ROP), focusing on the relationship between serum vascular endothelial growth factor (VEGF) concentration, refractive parameters, and optical coherence tomographic angiography (OCTA) findings.</p><p><strong>Methods: </strong>A prospective observational cohort of 198 patients who underwent fundus examinations at our hospital from January 2020 to December 2022, including 50 with myopia after regressed ROP (ROP-myopia group), 48 without myopia after regressed ROP (ROP-non-myopia group), 51 healthy myopic children (Myopia group), and 49 healthy non-myopic children (non-Myopia group), were enrolled. Serum VEGF levels, refractive parameters, and OCTA parameters were measured. Statistical analyses, including logistic regression, were performed to identify correlations between VEGF levels, OCTA parameters, and refractive outcomes.</p><p><strong>Results: </strong>The ROP-myopia group had higher diopter (3.66 ± 0.83 D), lens thickness (4.91 ± 0.91 mm), and axial length (24.30 ± 1.58 mm), along with elevated serum VEGF levels (302.8 ± 14.00 pg/ml), compared to other groups (<i>p</i> < 0.05). Retinal vascular density (VD) and central foveal thickness (CFT) was higher in the ROP-myopia group (<i>p</i> < 0.05). VEGF, VD, and CFT were identified as independent risk factors for abnormal refractive parameters, with an ROC curve area of 0.9918 (<i>p</i> < 0.05), highlighting their significant roles in myopia development after regressed ROP.</p><p><strong>Conclusion: </strong>The study highlights the significant influence of VEGF, VD, and CFT on refractive outcomes in children with regressed ROP. Monitoring changes in these parameters is crucial for early intervention to reduce the risk of myopia development.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"956-964"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pneumatic Trabeculectomy: A Modification in Conventional Trabeculectomy.","authors":"Shikha Gupta, Monika Arora, Karthikeyan Mahalingam, Viney Gupta, Pradeep Venkatesh","doi":"10.1080/02713683.2025.2513554","DOIUrl":"10.1080/02713683.2025.2513554","url":null,"abstract":"<p><strong>Purpose: </strong>We developed a novel technique called \"pneumatic trabeculectomy\"(PTB) which uses constant pressure air infusion <i>via</i> the Constellation Vision System (Alcon. Laboratories, Inc., Fort Worth, TX, USA) system to prevent anterior chamber collapse/intraocular pressure fluctuations during trabeculectomy in high-risk cases. In this study, we compared the efficacy and safety of PTB with conventional trabeculectomy surgery.</p><p><strong>Methods: </strong>In this prospective, interventional, nonrandomized, comparative pilot study, certain high-risk cases planned for trabeculectomy were assigned to Group A (conventional trabeculectomy) or Group B (pneumatic trabeculectomy). The primary outcome measure was to assess the anterior chamber (AC) fluctuations (through assessing anterior chamber shallowing/collapse), the frequency of need to form AC, and the occurrence of any intra-operative/early postoperative complications.</p><p><strong>Results: </strong>Of the 48 eligible participants, 24 were assigned to Group A and Group B. The mean surgical time required to complete the surgery was 17.63 ± 1.44 min in group A and 17.21 ± 1.50 min in group B (<i>p</i> = 0.83). In group A, 83.3% (20/24)eyes, anterior chamber collapsed during the step of scleral osteotomy/iridectomy compared to 4.17% (1/24) eyes in group B (<i>p</i> < 0.001) (Fischer's test). The anterior chamber remained stable throughout the surgery in Group B, while AC formation was required at least twice (mean 2.3 ± 0.7) in eyes undergoing conventional trabeculectomy in group A (<i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>PTB in high-risk cases had a significantly lower incidence of intra-operative anterior chamber collapse, requiring less frequent AC reformations, making it a safer alternative to conventional trabeculectomy.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"951-955"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144215183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Validation of Compensation Algorithm in Healthy Volunteers Using Spectral Domain Optical Coherence Tomography Angiography.","authors":"Giulia Corradetti, Zhongdi Chu, Louay Almidani, Federico Corvi, Ruikang K Wang, SriniVas R Sadda","doi":"10.1080/02713683.2025.2512581","DOIUrl":"10.1080/02713683.2025.2512581","url":null,"abstract":"<p><strong>Purpose: </strong>To generate and validate a spectral domain optical coherence tomography angiography (SD-OCTA) device-specific algorithm to compensate for signal attenuation in choriocapillaris (CC) en face OCTA slabs.</p><p><strong>Methods: </strong>Healthy subjects were imaged on SD-OCTA with a 6 × 6 mm pattern at the Doheny-UCLA Eye Centers. The CC slabs were segmented at the level of the Bruch's membrane using a 16-μm thick slab with the inner boundary located 4 μm below the Bruch's membrane. The CC slabs were exported and normalized. The percentage of CC flow deficits (CC FD %) was computed on binarized slabs before and after the application of an SD-OCTA specific compensation algorithm. On the same cohort, we also tested the compensation algorithm previously developed for SS-OCTA CC slabs.</p><p><strong>Results: </strong>Twenty-eight eyes from 28 subjects were included in the analysis. The mean (SD) CC FD % was 13.15 (3.91) for the normalized and compensated (SD-OCTA specific) images and 13.73 (4.20) for the normalized and uncompensated images (<i>p</i> = 0.1). The compensated and uncompensated CC FD were strongly correlated (<i>p</i> < 0.001). Bland-Altman plots demonstrated good agreement between the compensated and uncompensated CC slabs for the quantification of CC FD. When applying the SS-OCTA compensation algorithm on the SD-OCTA CC slabs, there was a statistically significant difference between CC FD% measured on the compensated and uncompensated CC slabs (<i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>An SD-OCTA specific compensation algorithm can be applied which does not cause the loss of artifactual FD in healthy eyes, with similar CC FD% values in compensated and uncompensated images.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"926-933"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Inter-Device Agreement in Quantifying Choriocapillaris Flow Deficits in Healthy Eyes.","authors":"Giacomo Boscia, Ramya Gnanaraj, Giulia Corradetti, Ceren Soylu, Shin Kadomoto, Yongsok Ji, Wongsiri Taweebanjongsin, Li Su, Iksoo Byon, Srinivas R Sadda","doi":"10.1080/02713683.2025.2506524","DOIUrl":"10.1080/02713683.2025.2506524","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the computation of the choriocapillaris flow deficit obtained from three different optical coherence tomography angiography devices in healthy subjects.</p><p><strong>Methods: </strong>Twenty-six healthy subjects were included in this post hoc analysis of data from a prospective healthy subject optical coherence tomography angiography study. Fovea-centered 6 × 6 optical coherence tomography angiography volume scans were obtained by all three devices: Heidelberg Spectralis spectral domain optical coherence tomography angiography (Heidelberg, Germany) using a full spectrum probabilistic algorithm (512 × 512 pixels); Zeiss Cirrus 5000 AngioPlex (Zeiss Meditec, Dublin, CA) (spectral domain-optical coherence tomography angiography) using the optical microangiography algorithm (350 × 350 pixels); Zeiss PLEX Elite 9000 swept source optical coherence tomography angiography (Zeiss Meditec, Dublin, CA) using the optical microangiography algorithm (500 × 500 pixels). Choriocapillaris slabs were binarized using Image J (Bethesda, MD) and the choriocapillaris flow deficit % was measured applying a Phansalkar radius of ∼20 µm, adjusted for each device based on the size and resolution of the images.</p><p><strong>Results: </strong>Twenty-six healthy eyes of 26 subjects with no ocular or systemic disease were included in this analysis. The mean age of the subjects was 47.60 ± 13.00 (range, 26-69) years and 46.15% were females. The choriocapillaris flow deficit % measured by the devices varied significantly from each other (<i>p</i> < .01). The mean choriocapillaris flow deficit % measured by the Spectralis (Heidelberg, Germany) was the highest at 57.00% (±13.21%), followed by the Angioplex at 25.70% (±9.00%), and the Plex Elite at 7.62 (±3.06%). There was a significant positive correlation between choriocapillaris flow deficit % measured by swept source-optical coherence tomography angiography and spectral domain-optical coherence tomography angiography devices (Angioplex and PLEX Elite) using the optical microangiography algorithm (<i>r</i> = 0.78, <i>p</i> < .01). Of note, this correlation was better than the correlation between two spectral domain-optical coherence tomography angiography devices using different algorithms (Spectralis, Heidelberg, Germany, full spectrum probabilistic algorithm and Angioplex optical microangiography) (<i>r</i> = 0.389, <i>p</i> = .04).</p><p><strong>Conclusion: </strong>The correlation between swept source and spectral domain optical coherence tomography angiography devices using the same optical coherence tomography angiography algorithm is better than between spectral domain-optical coherence tomography angiography devices using different algorithms.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"965-971"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Posterior Polar Cataracts: A Comprehensive Review of Management Strategies.","authors":"Manasi Tripathi, Manpreet Kaur, Jeewan Singh Titiyal, Sridevi Nair","doi":"10.1080/02713683.2025.2506526","DOIUrl":"10.1080/02713683.2025.2506526","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the recent updates on etiopathogenesis, clinical features, imaging modalities, and management strategies for challenging posterior polar cataracts.</p><p><strong>Methods: </strong>A thorough review was conducted by systematically analyzing the literature published on posterior polar cataracts, including its etiopathogenesis, clinical presentation, imaging modalities, surgical techniques, newer innovations and postoperative outcomes. The comprehensive search was performed on three databases (PubMed, Scopus, and Google Scholar) using relevant keywords such as \"posterior polar cataract,\" \"ASOCT\", \"UBM\", \"femtosecond laser,\" \"phacoemulsification\" and \"complications.\" Articles published in English were included, with priority given to peer-reviewed studies, clinical trials, and systematic reviews. Additional references were identified through cross-referencing key publications. The gathered data were synthesized to provide an overview of current knowledge and evolving perspectives in the management of posterior polar cataracts.</p><p><strong>Results: </strong>This mini-review comprehensively analyses and subsequently highlights the various clinical signs and imaging peculiarities seen on different investigative modalities to identify posterior polar cataracts. The information thus gathered will immensely help surgeons to effectively perform risk stratification, formulate the appropriate surgical plan, and manage patient expectations. Numerous surgical techniques have also been identified and extensively discussed to manage posterior polar cataracts in different scenarios.</p><p><strong>Conclusion: </strong>This mini-review serves as a comprehensive guide for both trainee and practicing ophthalmologists alike, updating them on recent advances in posterior polar cataracts. It also highlights the inherent challenges and key considerations that clinicians must carefully navigate in this evolving field.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"873-880"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144136034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Segment Measurement and Reproducibility in Pediatric Eyes Using Quantitative Ultrasound Biomicroscopy.","authors":"Trisha Miglani, Michael Chang, Libby Wei, Dhruv Shah, Taylor Kolosky, Moran R Levin, Alfred Vinnett, Camilo Martinez, Marlet Bazemore, Mohamad Jaafar, William Madigan, Janet L Alexander","doi":"10.1080/02713683.2025.2503207","DOIUrl":"10.1080/02713683.2025.2503207","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to provide an evidence-based protocol for iris measurement from ultrasound biomicroscopy (UBM) images with reproducibility analysis and resulting normative iris thickness dataset of the pediatric human iris by age.</p><p><strong>Methods: </strong>Healthy pediatric subjects (14 subjects, 25 eyes, mean age 2.0 ± 1.2 years) were recruited prospectively and underwent UBM imaging. Iris parameters were measured in 4 UBM images per eye in raw image and processed edge detection format. Agreement and variability were evaluated. Regression assessed the association between measurement differences and the variables expected to influence measurement reproducibility (image quality, orientation, and processing). Iris thickness by age was reported.</p><p><strong>Results: </strong>Intraclass correlation was >0.6 and correlation was >0.7 for all parameters. Coefficient of variation was <30% for iris measurements not involving the ciliary body. Image quality improved reproducibility but was not statistically significant (<i>p</i> = 0.10). Age of subject, edge detection, and image orientation were also not significant. Iris thickness increased with increasing age (<i>r</i> = 0.63, <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>This study demonstrated reproducible iris measurements using a prospective protocol. We found image features, including image quality and edge detection pre-processing, were not critical to reproducibility. In the future, clinical correlations with iris morphology may be more rigorously studied using a well-defined, reproducible, and quantitative approach as presented in this UBM-based image analysis protocol.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"903-910"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of IDO Activity in Cataract Progression: Correlation to Age and Cataract Severity.","authors":"Arturs Zemitis, Juris Vanags, Kristaps Klavins, Guna Laganovska","doi":"10.1080/02713683.2025.2506118","DOIUrl":"10.1080/02713683.2025.2506118","url":null,"abstract":"<p><strong>Purpose: </strong>Cataract is a prevalent, progressive lens disorder characterized by gradual opacity, often related to aging. Oxidative stress, ultraviolet radiation, and inflammation contribute to lens damage and protein modifications. Indoleamine 2,3-dioxygenase plays a critical role in tryptophan metabolism, with kynurenines implicated in various diseases. This study aimed to assess IDO activity in cataract patients by analyzing IDO activity in aqueous humor.</p><p><strong>Methods: </strong>The study included 170 cataract surgery patients (60 males, 110 females; mean age 73.9 ± 9.43 years). Cataract severity was categorized using the SPONCS system: SPONCS 1 (1.8%), SPONCS 2 (30.6%), SPONCS 3 (35.3%), SPONCS 4 (11.8%), and SPONCS 5 (20.6%). Aqueous humor samples (50-120 µL) were collected <i>via</i> paracentesis and analyzed using HILIC liquid chromatography with mass spectrometry. Target metabolite quantification was performed using internal standards and calibration curves.</p><p><strong>Results: </strong>Significant differences in IDO activity were observed across SPONCS groups (X²(4) = 12.0, <i>p</i> = .018, Ɛ²= 0.0707), particularly between SPONCS 2 and SPONCS 5 (<i>p</i> = .013). Age differences across SPONCS groups were also significant (<i>p</i> < .001). Males had lower tryptophan levels than females (<i>p</i> = .027). Correlations were found between SPONCS and IDO activity (r_s = -0.255, <i>p</i> < .001), SPONCS and kynurenine (r_s = 0.196, <i>p</i> = .011), and kynurenic acid with kynurenine (r_s = 0.355, <i>p</i> < .001).</p><p><strong>Conclusion: </strong>Patients with SPONCS 2 cataract exhibit increased susceptibility to elevated IDO activity and heightened kynurenine production. IDO serves as a more reliable prognostic marker for cataract progression than chronological age. Furthermore, IDO activity may be associated with reduced glutathione levels in human lens epithelial cells, suggesting a potential link between the enzyme and oxidative stress within the lens.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"919-925"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Kisspeptin Suppresses the Growth of Primary Pterygial Cells via Inhibiting Chemokine (C-X-C Motif) Ligands in Microenvironment.","authors":"Peng Wu, Shanshan Liu, Tingting Xu, Guoliang Zhao","doi":"10.1080/02713683.2025.2511866","DOIUrl":"10.1080/02713683.2025.2511866","url":null,"abstract":"<p><strong>Purpose: </strong>Pterygium is a prevalent ocular surface condition characterized by its extension toward the cornea at the corneoscleral junction. The etiology and development of pterygium are not fully understood. The discovery of new biomarkers may facilitate early intervention and the prevention of postoperative recurrence.</p><p><strong>Methods: </strong>Kisspeptin and GPR54 expression in pterygium were investigated <i>in vivo</i> by qPCR, Western blotting (WB), and immunohistochemistry (IHC). Primary pterygial cells were treated with Kiss1 over-expression and GPR54 inhibitor and subsequently subjected to RNA sequencing. Signaling pathways were examined using WB and immunofluorescence (IF).</p><p><strong>Results: </strong>The Kisspeptin/GPR54 system is down-regulated in pterygium. Ectopic over-expression of kisspeptin or GPR54 suppresses the cell growth of pterygial cells, accompanied by downregulation of chemokine signaling pathways (CXCL1, CXCL6 and CXCL12) and activation of the TGFβ, PI3K/Akt, p38 and ERK pathways as indicated by RNA-seq analysis. Furthermore, administration of the chemokines CXCL1, CXCL6 and CXCL12 significantly enhances the proliferation of pterygial cells.</p><p><strong>Conclusions: </strong>We reveal that kisspeptin system exerts an anti-pterygium effect, and a portion of chemokines induced by kisspeptin plays an essential role in pterygium growth.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"894-902"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Scleral Rigidity and Corneal Stress-Strain Measurements with Induced Elevation of Intraocular Pressure in Healthy Eyes.","authors":"Graziela Boschetti, Valeria Batista Boreck Seki, Tiago Santos Prata, Jayter Silva Paula","doi":"10.1080/02713683.2025.2509565","DOIUrl":"10.1080/02713683.2025.2509565","url":null,"abstract":"<p><strong>Purpose: </strong>To correlate scleral rigidity and corneal stiffness parameters with induced elevation of intraocular pressure (IOP) in healthy subjects using an ophthalmodynamometer.</p><p><strong>Methods: </strong>A combined calculation of applanation and indentation tonometric measurements using the Calixto nomogram was used to estimate scleral rigidity (SR) in healthy adults. The stiffness parameter (at first applanation - SP-A1), stress-strain index (SSI), and central corneal thickness were determined using the Corvis ST. Then, all eyes underwent acute IOP elevation through ocular compression using an ophthalmodynamometer at four crescent steps. Univariate and multivariate regression analyses were used to investigate the association between intraocular pressure increase and ocular biomechanical parameters.</p><p><strong>Results: </strong>Fifty-four eyes from 27 participants were included (mean age, 55.9 ± 9.9 years). The mean baseline IOP was 12.9 mmHg. The average values for SR, SP-A1, and SSI were 0.025 AU, 113.8 mmHg/mm, and 1.28, respectively. During ocular compression, IOP significantly increased in all eyes (mean change, 22.4 ± 4.3 mmHg; <i>p</i> < 0.001). The multivariable analysis showed that the magnitude of the rise in IOP was correlated only with SR (coefficient= 178.35; <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>Scleral, but not corneal, biomechanical parameters correlate independently with the magnitude of acute IOP increase in healthy eyes. These findings support further biomechanical studies involving patients with glaucoma to better understand the relationship between ocular compliance and its mechanical response to different IOP levels.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"934-939"},"PeriodicalIF":2.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}