异维甲酸治疗下痤疮患者视网膜血管改变:光学相干断层扫描血管造影研究。

IF 2 4区 医学 Q3 OPHTHALMOLOGY
Serhat Eker, Gülcan Saylam Kurtipek, Yalcin Karakucuk, Fatma Tuncez Akyurek, Mustafa Tugrul Ugur, Cahit Yavuz
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引用次数: 0

摘要

目的:本研究旨在利用口服异维甲酸结合光学相干断层扫描血管造影评估痤疮患者的视网膜和脉络膜微血管。材料与方法:使用Triton扫描源深范围成像光学相干断层扫描设备(Topcon Corp., Tokyo, Japan)对101例使用异维甲酸诊断为痤疮的患者的101只眼和105名健康受试者的105只眼进行视网膜和脉络膜评估。检测患者的浅表(VDs)、深部(VDd)和绒毛膜毛细血管(VDc)密度。测量浅层(FAZs)和深层(FAZd)的中央凹无血管区,以及黄斑中央厚度(CMT)和中央凹下脉络膜厚度(SFCT)。结果:共评估男性32例,女性69例。异维甲酸使用的平均持续时间为81天(范围:30-210天)。累计用药剂量2334 mg(范围600-7200 mg)。痤疮组VDs、VDd与对照组比较差异无统计学意义(p < 0.05)。与对照组相比,患者的所有部门VDc值均显著高于对照组(p = 0.048和p = 0.041)。与对照组相比,患者组的平均CMT显著降低(p = 0.001),而平均SFCT显著增加(p = 0.002)。使用异维甲酸3个月以上患者的VDc优值显著高于使用异维甲酸3个月以下患者(p = 0.01)。除了鼻部VDc值(r = -0.199, p = 0.046)外,我们没有发现与异维甲酸总剂量有任何相关性。结论:使用异维甲酸可观察痤疮患者黄斑微血管的改变。特别是,检测到绒毛膜毛细血管血流显著增加。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Retinal Vascular Changes in Acne Patients Under Isotretinoin Treatment: An Optical Coherence Tomography Angiography Study.

Purpose: This study was designed to assess retinal and choroidal microvasculature in acne patients using oral isotretinoin with optical coherence tomography angiography.

Materials and methods: One hundred and one eyes of 101 patients diagnosed with acne using isotretinoin and 105 eyes of 105 healthy subjects underwent retinal and choroidal assessment with the Triton swept-source deep range imaging optical coherence tomography device (Topcon Corp., Tokyo, Japan). The patients' superficial (VDs), deep (VDd), and choriocapillar (VDc) vascular densities were examined. Foveal avascular zones in the superficial (FAZs) and deep (FAZd) layers, as well as the central macular thickness (CMT) and subfoveal choroidal thickness (SFCT), were measured.

Results: In total, 32 males and 69 females were assessed. The mean duration of isotretinoin use was 81 days (range: 30-210 days). The cumulative dose of medication used was 2334 mg (range: 600-7200 mg). VDs and VDd showed no differences between the acne patients and the controls (p > 0.05). All sectors of the VDc values were significantly higher in the patients compared to the controls (p < 0.05). FAZs and FAZd were significantly higher in the patients compared to the controls (p = 0.048 and p = 0.041, respectively). The mean CMT significantly decreased in the patient group compared to the control group (p = 0.001), while the mean SFCT significantly increased (p = 0.002). The VDc superior values of the patients who used isotretinoin for more than 3 months were significantly higher than those of the patients who used the drug for less than 3 months (p = 0.01). We did not find any correlation with the total dose of isotretinoin, except for the nasal sector value of VDc (r = -0.199, p = 0.046).

Conclusions: Alterations of macular microvasculature were observed in acne patients using isotretinoin. In particular, a significant increment in choriocapillaris blood flow was detected.

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来源期刊
Current Eye Research
Current Eye Research 医学-眼科学
CiteScore
4.60
自引率
0.00%
发文量
163
审稿时长
12 months
期刊介绍: The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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