Current Eye Research最新文献

{"title":"Response to the Letter to the Editor: Expression of PAX6 and Keratocyte-Characteristic Markers in Human Limbal Stromal Cells of Congenital Aniridia and Healthy Subjects, <i>In Vitro</i>.","authors":"Zhen Li, Tanja Stachon, Julia Zimmermann, Simon Trusen, Fabian N Fries, Maximilian Berger, Shweta Suiwal, Ning Chai, Berthold Seitz, Lei Shi, Maryam Amini, Nóra Szentmáry","doi":"10.1080/02713683.2025.2497335","DOIUrl":"10.1080/02713683.2025.2497335","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"871-872"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143962651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seven-Year Observation of Posterior Corneal Elevations After Small Incision Lenticule Extraction in Myopic Patients with Thin Corneas.","authors":"Weijung Ten, Fei Xia, Shengtao Liu, Bingqing Sun, Zimeng Zhai, Xingtao Zhou, Jing Zhao","doi":"10.1080/02713683.2025.2495217","DOIUrl":"10.1080/02713683.2025.2495217","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the long-term stability of the posterior corneal surface in myopic patients with thin corneas after Small Incision Lenticule Extraction (SMILE).</p><p><strong>Methods: </strong>This study involved 60 eyes from 60 patients (mean spherical equivalent (SE): -5.81 ± 1.79 D), divided into two groups based on preoperative central corneal thickness (CCT): Group A (CCT < 510 μm, thin cornea) and Group B (CCT ≥ 510 μm, normal cornea), with 30 eyes per group. Data collected preoperatively and 7 years postoperatively included visual acuity, SE, efficacy and safety indices, intraocular pressure, axial length, and posterior corneal surface elevation measured by Pentacam.</p><p><strong>Results: </strong>No significant long-term complications were observed. Efficacy and safety indices were similar: 0.94 ± 0.16 and 1.07 ± 0.11 in Group A, and 0.94 ± 0.17 and 1.07 ± 0.16 in Group B. In Group A, posterior central elevation (PCE) increased significantly from baseline, while posterior thinnest elevation (PTE) decreased. Group B showed a significant increase in mid-peripheral elevation at 4 mm (MPE-4 mm). Subgroup analysis revealed increased PTE and MPE-6 mm in low-to-moderate myopia in Group A, and increased peripheral elevations in similar myopia levels in Group B. High myopia patients showed no significant changes. Correlation analysis in Group A showed that changes in 7-year PTE were negatively correlated with residual bed thickness (RBT) and positively correlated with the ablation ratio (AR). Similarly, changes in PCE and PTE correlated with RBT and AR.</p><p><strong>Conclusion: </strong>SMILE effectively corrects myopia long-term but increases posterior surface elevation in thin corneas. Patients with high myopia and thin corneas should monitor RBT and AR to ensure long-term corneal stability and safety.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"803-811"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143983402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of Refractory Glaucoma, a New Surgical Paradigm: Review of the Literature.","authors":"Victoria Heintz, Paul Bastelica, Christophe Baudouin, Yves Lachkar, Antoine Labbé","doi":"10.1080/02713683.2025.2494799","DOIUrl":"10.1080/02713683.2025.2494799","url":null,"abstract":"<p><strong>Purpose: </strong>To review current therapeutic strategies and innovations in the management of refractory glaucoma, with a focus on recent advancements in implantable surgical devices.</p><p><strong>Methods: </strong>A comprehensive literature search across PubMed, Embase, and Cochrane Library, included terms such as \"refractory glaucoma,\" \"posterior drainage implants,\" \"cyclodestruction,\" and \"minimally invasive glaucoma surgery.\" Articles discussing surgical and medical interventions, as well as device innovations, were included.</p><p><strong>Results: </strong>Therapeutic options include creating new sites for filtering surgery, posterior drainage implants, minimally invasive devices, cyclodestruction, or continuing medical management without surgery.</p><p><strong>Conclusion: </strong>Therapeutic decisions regarding refractory glaucoma should be made on a thoughtful, individualized basis, carefully weighing the expected benefits against the potential risks for the patient. Recent innovations in implantable devices expand the range of surgical possibilities.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"771-784"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956552","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SERPINA3 in Diabetic Retinopathy: A Pilot Study Assessing the Impact of Prior COVID-19 Infection on Patients.","authors":"Arthur Miller, Eunheh Koh, Rebekah Robinson, Vikas Kumar, Ashok Sharma, Shruti Sharma","doi":"10.1080/02713683.2025.2494795","DOIUrl":"10.1080/02713683.2025.2494795","url":null,"abstract":"<p><strong>Purpose: </strong>SERine Protease INhibitor clade A member 3 (SERPINA3), a protease inhibitor involved in the acute phase response, is regulated by interleukin 6 trans-signaling, a pro-inflammatory pathway associated with diabetic retinopathy (DR) pathogenesis. We hypothesized that SERPINA3 may serve as a biomarker to distinguish DR patients from diabetic patients without retinopathy.</p><p><strong>Methods: </strong>We measured serum SERPINA3 levels in DR patients and demographically matched diabetic patients without retinopathy to assess the biomarker potential of SERPINA3. History of COVID-19 infection was included as a demographic variable.</p><p><strong>Results: </strong>Our results showed that SERPINA3 levels did not vary between cases and controls, nor was there any correlation with disease severity as measured by hemoglobin A1c and diabetic retinopathy stage. We found that excluding patients with a history of COVID-19 infection increased the predictive value of SERPINA3, and that SERPINA3 levels were significantly increased in those subjects hospitalized due to COVID-19. The predictive value of SERPINA3 for hospitalization was similar to age, duration of diabetes, and HbA1c in our cohort.</p><p><strong>Conclusions: </strong>Overall, SERPINA3 had poor sensitivity and specificity for identifying DR patients, and COVID-19 infection history significantly increased variance in SERPINA3 levels. Further investigation into the potential of SERPINA3 as DR biomarker should be sufficiently powered to account for the potentially confounding effects of COVID-19 infection.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"839-844"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinol Binding Protein-4 and Galectin-3 Levels in Type II Diabetes: Their Impact on Retinopathy Risk.","authors":"Rajendran Sharmila, Dhanashree Ratra, Lawrence D Cruze, Reddy Prashanth, Saravana Kumar, Gopalan Sowmya, P Ravi Shankar, Ramasamy Magesh, Annamalai Radha, Kuppan Kaviarasan","doi":"10.1080/02713683.2025.2498029","DOIUrl":"10.1080/02713683.2025.2498029","url":null,"abstract":"<p><strong>Purpose: </strong>Retinol binding protein-4, a lipocalin family member, and galectin-3, a lectin family member, link their potential role in modulating glucose metabolism and inflammation. This study aims to explore retinol binding protein-4 and galectin-3's role as the disease progresses from prediabetes to diabetic retinopathy and to ascertain whether these variables could serve as risk or diagnostic indicators for diabetic retinopathy.</p><p><strong>Methods: </strong>This study includes 100 patients divided into three groups, diabetic retinopathy (<i>n</i> = 39), type 2 diabetes mellitus (<i>n</i> = 41), and prediabetes (<i>n</i> = 21), based on inclusion and exclusion criteria. Serum levels of retinol binding protein-4 and galectin-3 were assessed by sandwich ELISA. Immunofluorescence analysis was employed to localize retinol binding protein-4 and galectin-3 in the retinal layers. The increase in serum retinol binding protein-4 levels was validated by quantitative western blot analysis. The HDOCK tool was used to identify the protein-protein interactions between retinol binding protein-4 and VEGF.</p><p><strong>Results: </strong>Serum retinol binding protein-4 levels were higher in diabetic retinopathy and type 2 diabetes mellitus compared to prediabetes (<i>p</i> < 0.0001). Further, western blot analysis confirmed a significant twofold increase in diabetic retinopathy compared to the prediabetes groups (<i>p</i> = 0.0423). Serum galectin-3 levels were insignificantly higher in diabetic retinopathy and type 2 diabetes mellitus when compared to prediabetes. The receiver operating characteristic curve analysis, the area under the curve values, also indicates that serum retinol binding protein-4 had acceptable performance (area under the curve: 0.7965 and 0.9007) for the comparison between prediabetes vs. type 2 diabetes mellitus and prediabetes vs. diabetic retinopathy, respectively, as compared to serum galectin-3 (area under the curve: 0.6961 and 0.7008). In the IF analysis, retinol binding protein-4 localization was more common in the photoreceptor region and the retina vessels, whereas galectin-3 was distributed in the ganglion cell layer of the retina. The strong binding between retinol binding protein-4 and the VEGFA and VEGFB isoforms was observed during the protein-protein interaction study.</p><p><strong>Conclusion: </strong>This study reveals that retinol binding protein-4 seems to be a diagnostic marker for diabetic retinopathy, which requires further investigation.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"845-854"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Meibomian Gland Expression on Optical Quality in Patients with Meibomian Gland Dysfunction.","authors":"Hongzhe Li, Wentao Tong, Man Hu, Ziqi Meng, Pingjun Chang, Yune Zhao","doi":"10.1080/02713683.2025.2497324","DOIUrl":"10.1080/02713683.2025.2497324","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the changes in meibomian gland function, ocular surface parameters, and optical quality before and after meibomian gland expression in patients with meibomian gland dysfunction (MGD).</p><p><strong>Methods: </strong>Patients with MGD underwent meibomian gland expression once weekly for 4 consecutive weeks. Comprehensive assessments, including the Ocular Surface Disease Index questionnaire, tear break-up time, corneal fluorescein staining, lid margin abnormality grading, meibum expressibility and quality evaluations, Schirmer I test (SIT), as well as optical quality examinations using the Pentacam and Optical Quality Analysis System II, were conducted before and after the treatment.</p><p><strong>Results: </strong>124 eyes of 62 patients were included in the study. Most meibomian gland function and ocular surface parameters showed significant improvement after treatment. Except for and coma (<i>p</i> = .029), no other significant changes in optical quality were observed. Changes in SIT were significantly correlated with changes in total corneal high-order aberrations (tHOA-4mm) (<i>r</i> = -.224, <i>p</i> = .019). Changes in objective scattering index were significantly associated with changes in spherical aberration (<i>r</i> = .219, <i>p</i> = .022), trefoil (<i>r</i> = .797, <i>p</i> < .001), total high-order aberrations (<i>r</i> = .408, <i>p</i> < .001) and total corneal spherical aberration (<i>r</i> = .590, <i>p</i> < .001).</p><p><strong>Conclusion: </strong>Meibomian gland expression effectively improves meibomian gland function and ocular surface parameters. However, it does not appear to significantly impact optical quality in patients with MGD.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"785-790"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143989287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue Light Irradiation Elicits Senescence of Corneal Endothelial Cells <i>In Vitro</i> by Provoking Energy Crisis, Inflammasome Assembly and DNA Damage.","authors":"Xin Zheng, Guo-Jian Jiang, Ting-Jun Fan","doi":"10.1080/02713683.2025.2497330","DOIUrl":"10.1080/02713683.2025.2497330","url":null,"abstract":"<p><strong>Purpose: </strong>The blue light from the digital screens endangers the visual system among which the corneas at the outmost of eyes are vulnerable to the irradiation. Therein, the human corneal endothelial (HCE) cells are crucial to maintain corneal transparency and their damage leads to HCE decompensation resulting in blindness ultimately. Thus, understanding the phototoxic effects of the blue light on the HCE cells and the underlying mechanisms is important for taking measures to protect the vision clarity from the blue-light hazard.</p><p><strong>Methods: </strong>We pulse-irradiated the HCE cell line cells at logarithmic phase for 3 passages using 440 nm blue light and examined the levels of reactive oxygen species (ROS), ATP, nicotinamide adenine dinucleotide (NAD⁺) and autophagy using cytochemistry assay to investigate the alterations of energy metabolism. Moreover, we examined the γH2AX⁺ cells using immunofluorescence and expression of poly(ADP-Ribose)polymerase1 (PARP1) using western blotting to investigate the degrees of DNA damage and repair. We also monitored the levels of inflammasome using western blotting and senescence associated secretory phenotypes (SASPs) of interleukin (IL)-8, IL-1β and IL-6 using qPCR and ELISA to investigate the inflammasome assembly and secretion of SASPs. We detected the senescent features with senescence-associated-β-galactosidase assay, p16 levels by western blotting, Lamin B1 localization by immunofluorescence observation, cell growth by EdU incorporation assay and confluence forming time and alterations of the cell morphology and relative areas by microscopy observation.</p><p><strong>Results: </strong>The HCE cells exhibited senescent features after blue-light-pulse-irradiation. The blue light provokes overproduction of ROS to decrease the levels of ATP, NAD⁺ and autophagy leading to energy crisis. Moreover, the excess ROS injure DNA and downregulate PARP1 resulting in stable cell-cycle arrest. The excess ROS also facilitate inflammasome assembly leading to hypersecretion of SASPs.</p><p><strong>Conclusion: </strong>The blue light elicits HCE cell senescence <i>via</i> inducing energy crisis, stable cell-cycle arrest and SASP hypersecretion.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"791-802"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comments on the Study of \"Expression of PAX6 and Keratocyte-Characteristic Markers in Human Limbal Stromal Cells of Congenital Aniridia and Healthy Subjects, In Vitro\".","authors":"Sücattin İlker Kocamış, Bedia Kesimal","doi":"10.1080/02713683.2025.2494797","DOIUrl":"10.1080/02713683.2025.2494797","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"870"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143986811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Efficacy of an Assistive Device for Blind People: A Prospective, Non-Randomized, Single Arm, and Open Label Clinical Trial.","authors":"Yiming Zhao, Shuo Yang, Yong Tao, Hao Kang","doi":"10.1080/02713683.2025.2495212","DOIUrl":"10.1080/02713683.2025.2495212","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy of an assistive device (BrainPort^® Vision Pro) for blind people in object recognition and orientation-and-mobility.</p><p><strong>Methods: </strong>This prospective, single arm, and open label clinical trial enrolled 24 participants who had profound visual impairment (visual acuity < 1/60 and/or visual field constriction <5°). After a three-hour training of BrainPort Vision Pro device instruction, participants were instructed to perform functional tasks including an assistive walking program and object recognition project. Five chances were given for each task, and success was defined as correctly completing at least three times. Success rates were used to evaluate the effectiveness of the device.</p><p><strong>Results: </strong>The success rates of participants wearing the device were significantly higher for both orientation-and-mobility task and objects/place-setting recognition tasks, compared to those without the aid. Device-related adverse events did not occur throughout the study.</p><p><strong>Conclusion: </strong>This is the first attempt to evaluate the efficacy of the BrainPort Vision Pro for blind people in China. It is shown as a viable assistive device for blind individuals to directly interact with their environments through a real perception from tongue stimulation, without remarkable side effects in the current study. With the advancement and popularization, more blind people will have access to and benefit from the BrainPort Vision Pro in the future.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"865-869"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine Learning-Driven Identification of Hematological and Immunological Biomarkers for Predicting Proliferative Diabetic Retinopathy Progression.","authors":"Sibo Zhao","doi":"10.1080/02713683.2025.2498035","DOIUrl":"10.1080/02713683.2025.2498035","url":null,"abstract":"<p><strong>Purpose: </strong>Proliferative Diabetic Retinopathy (PDR) is a severe complication of diabetes characterized by neovascularization and retinal detachment, leading to significant vision loss. This study investigates the predictive power of hematological and immunological markers in PDR progression.</p><p><strong>Methods: </strong>Data from 126 patients were analyzed using advanced machine learning techniques, including LASSO regression, elastic net modeling, and backward stepwise regression.</p><p><strong>Results: </strong>The findings identified age, gender, IL-1, and lymphocyte count (LYM) as significant predictors of PDR, with a high AUC value of 0.839 from the ROC curve analysis. These markers, particularly cytokines in the aqueous humor and peripheral blood, offer a convenient and rapid method for early detection and risk assessment of PDR.</p><p><strong>Conclusions: </strong>Despite the limitations of being a cross-sectional study with a relatively small sample size, the results highlight the clinical significance of these biomarkers and underscore the need for further validation in larger, more diverse populations. This study contributes to the development of targeted interventions and improved management strategies for diabetic retinopathy, emphasizing the importance of immunological health in disease progression.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"855-864"},"PeriodicalIF":1.7,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}