Current Eye Research最新文献

{"title":"Within-Eye Cyclotorsion and Astigmatic Correction.","authors":"Henry Bair","doi":"10.1080/02713683.2026.2750715","DOIUrl":"https://doi.org/10.1080/02713683.2026.2750715","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.7,"publicationDate":"2026-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149206719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Low-Dose Atropine on Choroidal and Anterior Scleral Thickness in Myopic Egyptian Children: A Randomized Controlled Trial.","authors":"Aya Mahmoud Abd El-Azeem, Esraa Abdelhakeem Diab, Nada Abdel Salam Abdel Aziz, Marwa A Karim, Amany Abd El-Fattah El-Shazly","doi":"10.1080/02713683.2026.2743443","DOIUrl":"https://doi.org/10.1080/02713683.2026.2743443","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to evaluate the short-term effect of low-dose atropine eye drops on subfoveal choroidal thickness (SFCT), anterior scleral thickness, and other ocular biometric parameters in myopic children.</p><p><strong>Methods: </strong>This prospective, randomized controlled trial included 92 myopic children aged 6-12 years. Participants were randomly assigned in a 1:1:1 ratio to receive 0.05% atropine, 0.01% atropine, or placebo eye drops nightly for 16 weeks. Only one eye (the right eye if both were eligible) was included per participant to avoid inter-eye correlation bias. Comprehensive ophthalmic examination was performed at baseline and at 4, 8, 12, and 16 weeks. SFCT and anterior scleral thickness were measured using spectral-domain optical coherence tomography (OCT). Axial length (AL), intraocular pressure (IOP), anterior chamber depth (ACD), and central corneal thickness (CCT) were also evaluated. Changes over time and between groups were analyzed using repeated-measures analysis. The trial was registered at ClinicalTrials.gov (NCT06265454).</p><p><strong>Results: </strong>Over the follow-up period, SFCT increased significantly in both treatment groups: from 350.21 ± 51.46 μm to 391.42 ± 48.41 μm in the 0.01% group (<i>p</i> = 0.025), and from 319.45 ± 89.28 μm to 396.48 ± 89.64 μm in the 0.05% group (<i>p</i> = 0.021). In contrast, SFCT decreased in the placebo group, from 389.55 ± 62.34 μm to 354.78 ± 50.99 μm (<i>p</i> = 0.117). Between-group analysis demonstrated significantly greater increases in the rate of SFCT change in both atropine groups than in the placebo group throughout follow-up. Although no significant within-group changes in axial length were observed, both atropine groups exhibited significantly lower rates of axial elongation than the placebo group. Anterior scleral thickness, CCT, ACD, and IOP remained stable across all study groups (<i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>Both low-dose atropine concentrations resulted in short-term choroidal thickening in Egyptian myopic children, with a stronger response in the 0.05% group. No significant changes were observed in anterior segment parameters or intraocular pressure. These findings support a concentration-dependent choroidal mechanism in myopia control.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Keratorefractive Lenticule Extraction (KLEx) Surgeries and Dry Eye: A Narrative Review of Predominantly Small Incision Lenticule Extraction-Based Evidence.","authors":"Xiangjun Chen, Catherine Joan Jackson, Kjell Gunnar Gundersen, Sten Ræder, Aleksandar Stojanovic, Danson Muttuvelu, Tor Paaske Utheim","doi":"10.1080/02713683.2026.2742121","DOIUrl":"https://doi.org/10.1080/02713683.2026.2742121","url":null,"abstract":"<p><p>Keratorefractive lenticule extraction (KLEx) is the newest widely adopted flapless refractive procedure. Small incision lenticule extraction (SMILE) accounts for most of the available evidence on postoperative dry eye, whereas evidence for newer KLEx platforms remains limited. This narrative review summarizes changes in dry eye symptoms, tear film parameters, corneal sensitivity, and corneal innervation after KLEx, as well as factors associated with postoperative dry eye and available treatment strategies. Most studies reported an early postoperative worsening of dry eye symptoms and tear film stability, followed by gradual recovery, usually within 3-6 months. Changes in tear production were less consistent. Compared with laser-assisted <i>in situ</i> keratomileusis, SMILE showed better preservation and earlier recovery of corneal sensitivity and innervation. However, the differences in dry eye symptoms and tear film parameters were less consistent among studies. Several treatments targeting different aspects of postoperative dry eye have been studied after KLEx, but the supporting evidence varies between interventions.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phaco-Trabeculectomy Versus Phaco-XEN63 Gel Stent in Primary Open-Angle Glaucoma and Cataract: A Retrospective Comparative Study.","authors":"Francesca Fantaguzzi, Gianluca Monsellato, Davide Morante, Davide Tomaselli, Paolo Nucci, Matteo Sacchi","doi":"10.1080/02713683.2026.2738345","DOIUrl":"https://doi.org/10.1080/02713683.2026.2738345","url":null,"abstract":"<p><strong>Purpose: </strong>To compare outcomes of XEN^® Gel Stent implantation (Phaco-XEN63) versus trabeculectomy (Phaco-Trab) combined with phacoemulsification in patients with primary open-angle glaucoma and visually significant cataract.</p><p><strong>Methods: </strong>Retrospective, single-center study. Surgical success at 12 months was defined with three intraocular pressure (IOP) thresholds: ≤18 mmHg with ≥20% reduction (criterion A), ≤15 mmHg (criterion B), and ≤12 mmHg (criterion C). Outcomes were classified as complete success (without medications) and qualified success (with or without medications). IOP, best-corrected visual acuity (BCVA), number of antiglaucoma medications, postoperative procedures and complications were recorded through 12 months.</p><p><strong>Results: </strong>Thirty-four eyes were included (Phaco-Trab, <i>n</i> = 16; Phaco-XEN63, <i>n</i> = 18). Both procedures significantly reduced IOP and medication use versus baseline. From 1 to 12 months, mean IOP was consistently lower after Phaco-Trab (all <i>p</i> < 0.05); at 12 months, mean IOP was 9.73 ± 3.68 mmHg (Phaco-Trab) and 13.41 ± 3.00 mmHg (Phaco-XEN63). Medication reduction was greater with Phaco-Trab (<i>p</i> = 0.017). Complete success was more frequent after Phaco-Trab under all three criteria, whereas qualified success differed significantly only under criterion C. Postoperative interventions were more frequent after Phaco-XEN63. Difference in BCVA change was not statistically significant.</p><p><strong>Conclusions: </strong>Both combined procedures effectively lowered IOP and reduced medication burden. However, Phaco-Trab was associated with lower IOP at 12 months and higher complete success rates. Given the small sample size and the retrospective, non-randomized design, these findings should be interpreted cautiously, particularly regarding qualified success and comparative safety.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149135309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface-Plasty Clinics: An Integrated Model for Bridging the Ocular Surface and the Adnexa.","authors":"Swati Singh","doi":"10.1080/02713683.2026.2737537","DOIUrl":"https://doi.org/10.1080/02713683.2026.2737537","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-2"},"PeriodicalIF":1.7,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premyopia Progression and Low-Dose Atropine Intervention in Children with Unilateral Myopia.","authors":"Chaoying Ye, Yuliang Wang, Yangfan Xu, Yujia Liu, Xuanqiao Lin, Wenqian Xing, Yiran Wang, Xiaomei Qu, Jianmin Shang","doi":"10.1080/02713683.2026.2728921","DOIUrl":"https://doi.org/10.1080/02713683.2026.2728921","url":null,"abstract":"<p><strong>Purpose: </strong>To compare refractive progression between myopic and premyopic eyes within the same children and evaluate the potential role of low-dose atropine on premyopia progression.</p><p><strong>Methods: </strong>This 12-month randomized controlled trial enrolled children aged 4-12 years with one myopic and one premyopic eye. Participants were assigned to three groups: no atropine intervention (NI), 0.01% atropine in myopic eye (MI), or bilateral intervention (BI). Spherical equivalent (SE) and axial length (AL) were measured at 3-month intervals. Linear mixed-effects models included all randomized participants, while generalized estimating equations with multiple imputation and Cox regression assessed myopic shift (ΔSE ≤ -0.50 D/year) and myopia onset.</p><p><strong>Results: </strong>Ninety-five of 104 children completed the study. In the NI group, myopic eyes showed greater progression than premyopic eyes, with adjusted interocular differences of -0.19 D (95% CI, -0.32 to -0.05; <i>p</i> = 0.007) in SE change and 0.08 mm (95% CI, 0.03 to 0.12; <i>p</i> = 0.001) in AL change. In premyopic eyes, BI showed 0.21 D less SE progression (<i>p</i> = 0.046) and 0.14 mm less AL elongation (<i>p</i> = 0.016) than MI, but neither differed significantly from NI. Myopic shift risk was lower in BI than MI (RR, 0.52; 95% CI, 0.27 to 0.99) and NI (RR, 0.50; 95% CI, 0.26 to 0.97). Atropine intervention (HR, 0.50; <i>p</i> = 0.037) and higher baseline SE (HR, 0.06; <i>p</i> < 0.001) were associated with a lower hazard of myopia onset.</p><p><strong>Conclusions: </strong>Untreated myopic eyes showed greater SE progression and AL elongation than their fellow premyopic eyes. 0.01% atropine treatment showed a potential effect in reducing myopic shift and incidence. Meanwhile, the management should be individualized according to baseline refraction and documented progression.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2026-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear Fluid Biomarkers for Ocular Pain.","authors":"Amalia Enríquez-de-Salamanca","doi":"10.1080/02713683.2026.2715211","DOIUrl":"10.1080/02713683.2026.2715211","url":null,"abstract":"<p><p>There is a growing interest in identifying potential biomarkers that can objectively serve as tools for diagnosis, monitoring, and treatment of ocular chronic pain. Although pain is a biological warning signal absolutely necessary for our survival, when it lasts for 3 or more months it becomes chronic and then it is considered a disease by itself. Chronic pain is a very disabling condition/disease which highly impairs the quality of life of patients. Development of ocular chronic pain, persistent and of high intensity, is present in some patients with dry eye disease (DED), or it can be triggered by some pathological events or after surgical procedures. However, in many of these cases the ocular clinical examination is apparently normal, and the explanation of that pain is not obvious. This type of pain is also difficult to treat because its pathophysiological mechanisms are not completely understood yet, and there are no standard criteria for its diagnosis. Several tear fluid biomarkers have been presented for different ocular diseases, and also for non-ocular, systemic diseases. Different studies have addressed the analysis of tear molecular profiles, including proteins, cytokines and neuromediators such as IL-9, MIP-1α, IL-10, IL-8, TNF-α, IL-6, Fractalkine, IL-1RA, Substance P, CGRP, NPY, and NGF levels associated with the presence of chronic ocular pain. Additionally, the preoperative tear levels of CGRP have been shown as predictive risk factor for ocular pain development after refractive surgery. These specific molecular profiles might help to explain the differences in symptomatology and clinical parameters in patients suffering from ocular pain and to identify those subjects more prone to develop it. Understanding the molecular bases underlying ocular pain will help in the search for effective, selective, and personalized therapies.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1223-1227"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148700838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing Analyte Concentrations in Paired Tear Fluid and Blood Samples.","authors":"Yutong Wang, Li Liang, Rudy M M A Nuijts, Marlies Gijs","doi":"10.1080/02713683.2025.2581623","DOIUrl":"10.1080/02713683.2025.2581623","url":null,"abstract":"<p><strong>Purpose: </strong>To compare analyte concentrations in paired tear fluid and blood samples, and to evaluate their correlations.</p><p><strong>Methods: </strong>Studies published between January 1974 and May 2024 and between May 2024 and March 2025, reporting analyte concentrations in tear fluid and blood (including whole blood, serum, or plasma), were identified from a recent scoping review and through searches of MEDLINE and EMBASE, respectively. Two reviewers independently screened studies and extracted relevant data. Concentration data were then pooled using a random-effects model. Comparisons between pooled tear fluid and blood concentrations were performed using Bayesian posterior simulation methods, in which the differences in concentrations were evaluated based on estimated posterior probabilities. Blood-to-tear and tear-to-blood ratios were calculated. A total of 72 significant correlation coefficients from 65 studies were analyzed.</p><p><strong>Results: </strong>A total of 367 paired tear fluid and blood concentrations for 138 analytes were collected. Based on their functional characteristics, these analytes were divided into nine categories. Most cytokines and neuromodulators exhibited higher concentrations in tear fluid than in blood, while antibodies, drugs, and other proteins or enzymes were generally found at higher concentrations in blood. The highest tear-to-blood ratio was for lactoferrin at 1281-fold, while the highest blood-to-tear ratio was observed for MMP-2 (400-fold). Most analytes (<i>n</i> = 64, 89%) showed positive correlations (<i>r</i> > 0), with the majority (<i>n</i> = 23, 32%) exhibiting strong positive correlations (<i>r</i> > 0.8).</p><p><strong>Conclusion: </strong>This comprehensive analysis demonstrates that analyte concentrations in paired tear fluid and blood vary according to their functional categories, with cytokines and neuromodulators generally enriched in tear fluid, and antibodies and drugs more abundant in blood. Strong positive correlations between tear fluid and blood concentrations for most analytes support the potential of tear fluid analysis for monitoring systemic physiological and pathological conditions.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1174-1185"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear Proteomics and Insights into Lacrimal Drainage Disorders: Lacriome Paper 8.","authors":"Pari N Shams, Mohammad Javed Ali","doi":"10.1080/02713683.2026.2647941","DOIUrl":"10.1080/02713683.2026.2647941","url":null,"abstract":"<p><strong>Purpose: </strong>To synthesize and evaluate current evidence from tear proteomic and cytokine profiling studies in lacrimal drainage disorders, with a primary focus on primary acquired nasolacrimal duct obstruction. This review aims to identify diagnostic biomarkers, elucidate underlying immunopathogenic mechanisms, and explore translational opportunities to improve clinical management and surgical outcomes.</p><p><strong>Methods: </strong>Fifteen peer-reviewed studies were systematically reviewed, encompassing proteomic, immunoassay, and cytokine analyses of tear fluid from adult and pediatric patients with nasolacrimal duct obstruction. Included investigations comprised pre- and post-surgical cohorts, subgroup analyses by age, sex, and systemic disease status, and multiple analytical platforms such as mass spectrometry, ELISA, and multiplex bead-based assays. Studies were evaluated for methodological rigor, reproducibility, and clinical applicability.</p><p><strong>Results: </strong>Across the included studies, a consistent upregulation of inflammatory cytokines-particularly IL-6, IL-8, TNF-α, IFN-γ, and VEGF-A-was observed in primary acquired nasolacrimal duct obstruction patients compared to controls. Proteomic alterations involving antimicrobial, stress-response, and epithelial repair proteins (e.g. S100A8/A9, prolactin-inducible protein, lipocalin-1) were recurrently reported. Distinct cytokine patterns were noted in pediatric and diabetic subgroups, while diurnal variation influenced cytokine expression in control eyes. Post-dacryocystorhinostomy cohorts demonstrated partial normalization of IL-1β and IL-6 levels, correlating with improved tear osmolarity, meniscus dynamics, and patient-reported outcomes. Proteomic findings further implicated systemic inflammation, hormonal modulation, and mucosal barrier dysfunction in primary acquired nasolacrimal duct obstruction pathogenesis.</p><p><strong>Conclusion: </strong>Tear proteomics has revealed a reproducible inflammatory and immune signature in lacrimal drainage disorders, positioning tear fluid as a valuable, noninvasive biospecimen for diagnosis, monitoring, and precision-based management. Emerging biomarker panels hold potential to stratify disease severity, predict surgical success, and guide individualized therapy. Future work should prioritize multicenter validation, standardized sampling protocols, and integration with advanced analytical and AI-driven diagnostic platforms.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1214-1222"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147572780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear Fluid: A Bridge Between Basic Biology and Modern Research Strategies.","authors":"Sonja Mertsch, Marlies Gijs","doi":"10.1080/02713683.2026.2721031","DOIUrl":"10.1080/02713683.2026.2721031","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1139-1140"},"PeriodicalIF":1.7,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148789453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}