Current Eye Research最新文献

{"title":"Is Selective Laser Trabeculoplasty Effective in Reducing Intraocular Pressure for Primary Angle-Closure Glaucoma? A Systematic Review and Meta-Analysis.","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1080/02713683.2025.2481306","DOIUrl":"https://doi.org/10.1080/02713683.2025.2481306","url":null,"abstract":"<p><strong>Purpose: </strong>Primary angle-closure glaucoma (PACG) is a significant cause of blindness globally, particularly in Asian populations, where it accounts for 25% of glaucoma cases. Selective laser trabeculoplasty (SLT) has emerged as a promising treatment for PACG, but its efficacy varies across studies. This meta-analysis aims to evaluate the effectiveness of SLT in reducing intraocular pressure (IOP) and compare outcomes between PACG and primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Scopus, Medline, and EMBASE up to July 2024 using predefined criteria. Studies assessing SLT in patients with PACG were included. Data extraction included study characteristics, SLT parameters, and primary outcomes, such as mean post-intervention IOP reduction and SLT failure rates. Statistical analysis was performed using pooled estimates with 95% confidence intervals (CI) through Comprehensive Meta-Analysis software.</p><p><strong>Results: </strong>Of the 754 potentially relevant articles assessed, 7 met the inclusion criteria. The mean IOP post-SLT among PACG patients significantly decreased to 17.30 mmHg (95% CI: 16.99-17.61; <i>p</i> = 0.0001). The SLT failure rate in PACG was 7.95% (95% CI: 6.15-10.28%; <i>p</i> = 0.00001). Studies reported varying trends in medication use and the need for further interventions post-SLT in PACG patients.</p><p><strong>Conclusions: </strong>This study comprehensively examined the effectiveness of SLT in treating PACG across multiple studies. Despite variations in sample sizes, demographics, and study locations, SLT effectively reduced IOP in PACG patients. The meta-analysis demonstrated a statistically significant decrease in mean post-SLT IOP, highlighting its therapeutic benefit despite notable heterogeneity among the included studies.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-11"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear Film Lipid Layer Thickness: Measurement Techniques, Normative Values and Alteration in Ocular Surface Diseases.","authors":"Sandhya Esam, Swati Singh, Nagaraju Konda, Rashmin Gandhi, Geeta K Vemuganti","doi":"10.1080/02713683.2025.2458735","DOIUrl":"https://doi.org/10.1080/02713683.2025.2458735","url":null,"abstract":"<p><strong>Purpose: </strong>Tear film instability is one of the principal pathomechanisms of dry eye disease (DED), arising from disrupted tear homeostasis, reduced tear volume, or lipid layer alterations. The lipid layer, secreted by the meibomian glands, can be imaged qualitatively and quantitatively. This review summarizes different lipid layer thickness (LLT) measurement techniques, normative values, and alterations in ocular surface disorders.</p><p><strong>Method: </strong>Full-texts of 88 of 236 searched articles from PubMed, ScienceDirect, and Google Scholar using the terms 'Tear film lipid layer thickness,' 'Lipid layer thickness', 'Tear film lipids,' 'Dry eye disease,' 'Meibomian gland dysfunction,' 'Meibography,' and 'Interferometry' were reviewed.</p><p><strong>Result: </strong>Advanced imaging techniques, such as LipiView, Oculus Keratograph 5M, and Tearscope, utilize interference principles, but are not interchangeable for measuring LLT. LLT ranges from 13 to 170 nm in healthy individuals, depending on the instrument and grading scale used. The reported central LLT values in DED vary from 33 to 84 nm, varying with disease severity. There are conflicting reports on the association between age, gender, and LLT values. LLT positively correlates with expressible meibomian glands, and negatively with gland loss. LLT has been associated with tear film breakup time, MGD severity, and blink pattern irregularities.</p><p><strong>Conclusion: </strong>The significant overlap in LLT values between the normal individuals and DED patients precludes its role in the diagnosis of DED. Future studies exploring LLT variations under different environmental conditions and across larger cohorts with varying DED severity are essential to enhance clinical applicability.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Lens Properties on Visual Acuity, Aniridia Associated Keratopathy and Secondary Glaucoma in Congenital Aniridia Subjects.","authors":"Annamária Náray, Fabian N Fries, Cristian Munteanu, Mária Csidey, Tanja Stachon, Neil Lagali, Achim Langenbucher, Barbara Käsmann-Kellner, Berthold Seitz, Nóra Szentmáry","doi":"10.1080/02713683.2024.2438687","DOIUrl":"10.1080/02713683.2024.2438687","url":null,"abstract":"<p><strong>Purpose: </strong>The potential risks and benefits of cataract surgery, in context of congenital aniridia (CA), are not widely understood, yet. Our purpose was to investigate the effect of lens properties on visual acuity (VA), aniridia-associated keratopathy (AAK) stage and presence of glaucoma at the Homburg Aniridia Center.</p><p><strong>Methods: </strong>CA subjects, examined at the Department of Ophthalmology of Saarland University between June 2003 and January 2022, were included. VA, slit-lamp examination, AAK grade, and glaucoma evaluation data were extracted from the medical records, from the first visit to the center. Eyes were categorized as clear lens, cataract, pseudophakic, aphakic, or subluxated lens. Patients were grouped by age (0-10, 10-20, 20-40, 40+ years).</p><p><strong>Results: </strong>In 553 eyes of 286 CA subjects (age 19.9 ± 19.9 (0-83) years, 46.1% males), analysis revealed significant differences in VA and mean IOP (ANOVA <i>p</i> < 0.0001; <i>p</i> = 0.001, respectively) with lens status. Lens status was strongly associated with AAK Grade and glaucoma presence (<i>p</i> < 0.0001 for both). In age subgroups, AAK Stage was strongly associated with lens status in the 0-10 years (<i>p</i> < 0.001), 10-20 years (<i>p</i> < 0.001), and 40+ years (<i>p</i> = 0.02) groups and lens status was strongly associated with glaucoma presence in the 0-10 years (<i>p</i> = 0.003) and 20-40 years (<i>p</i> = 0.002) groups. AAK Stage was the most advanced in pseudophakic and aphakic eyes and presence of glaucoma was more pronounced in pseudophakic, aphakic and subluxated lens eyes.</p><p><strong>Conclusions: </strong>In a large population of CA, previous cataract surgery was associated with higher AAK Grade and presence of secondary glaucoma both in postoperatively pseudophakic and aphakic eyes. Our data indicate that caution is warranted with cataract surgery in congenital aniridia.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"381-393"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SMP30 Alleviates Oxidative Stress and Regulates Ca²⁺-ATPase Activity in UVR-B-Induced Cataracts in Rats.","authors":"Tian Lan, Yongshun Liang, Qingqiao Gan, Hao Liang","doi":"10.1080/02713683.2024.2441253","DOIUrl":"10.1080/02713683.2024.2441253","url":null,"abstract":"<p><strong>Purpose: </strong>Oxidative stress, ultraviolet radiation, and calcium imbalance are key components in the onset and advancement of cataract, which continue to be the leading cause of blindness globally. An important newly discovered aging maker, Senescence marker protein 30 (SMP30) regulates calcium and participates in mitigating oxidative stress damage. Here, we examined the beneficial role of SMP30 in protecting against ultraviolet radiation type B (UVR-B)-induced cataract in rats.</p><p><strong>Methods: </strong>Wistar rats (2 months) were arbitrarily assigned into 4 groups of 10 rats. These groups included the Control group, UVR-B group, adeno-associated virus 2 vectors negative control (AAV2-NC) group, and adeno-associated virus 2-mediated overexpression of SMP30 (AAV2-SMP30) group. The control group received Phosphate-buffered saline (PBS) <i>via</i> injection, while the AAV2-NC group and AAV-SMP30 group were separately injected with AAV2-NC and AAV2-SMP30 vectors. In addition to the control group, the remaining three experimental groups were subjected to ultraviolet light exposure 4 weeks post-injection. The lens opacity was examined by stereoscopic microscope, and the lenses were separated to measure oxidative damage parameters particularly superoxide dismutase (SOD), glutathione peroxidase (GPX), and Ca²⁺-ATPase activity. The localization and expression of SMP30 and Ca²⁺-ATPase in the lenses were determined using immunohistochemistry and RT-qPCR.</p><p><strong>Results: </strong>After UVR-B irradiation, the AAV2-SMP30 group exhibited a substantial decrease in lens opacity compared to the UVR-B group. The results revealed a notable downregulation of SMP30 expression and the activities of SOD, GPX, and Ca²⁺-ATPase of rat lens following exposure to UVR-B radiation. However, SMP30 overexpression partially reversed these effects. <i>In vivo</i> experiments demonstrated SMP30 overexpression attenuated the UVR-B-induced decline in SOD, GPX, and Ca²⁺-ATPase activities.</p><p><strong>Conclusion: </strong>This study demonstrates that SMP30 has the potential to reduce lens opacity caused by UVR-B by increasing antioxidant stress and regulating Ca²⁺-ATPase activity. SMP30 might be a cutting-edge target for the treatment of cataracts.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"373-380"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual Function Under Bright Light Conditions Tested Using a Blue-Light Absorbing or Clear Lens in Pseudophakic Patients.","authors":"Billy R Hammond, Jacob B Harth, Lisa M Renzi-Hammond","doi":"10.1080/02713683.2025.2487073","DOIUrl":"https://doi.org/10.1080/02713683.2025.2487073","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the visual performance of a blue-light filter (BLF). The following visual parameters were assessed: glare disability (GD); chromatic contrast (CC); two-point light thresholds; and dysphotopsia symptoms (snowball and spoke diameter).</p><p><strong>Methods: </strong>Twenty-five pseudophakic patients previously implanted with a \"UV-only\" intraocular lens (IOL) were tested using a single-masked randomized cross-over design. In the control condition, a UV-only filter (matched to the implant) was used. In the test condition, a BLF was used (matching the absorbance profile of a common BLF IOL; Acrysof Natural and Clareon; Alcon Research Ltd). The intensity (expressed as log relative energy, LRE) of broad-band xenon light and a sky-blue background needed to veil a central grating target was used to measure GD and CC, respectively. The diameter of spokes/snowballs was determined by measuring their lateral extent induced by a bright white point source. Two-point light thresholds were measured as the separation between two small relatively intense point sources of light (Rayleigh criterion).</p><p><strong>Results: </strong>The BLF test lens resulted in improved CC (LRE 2.04 vs 1.83) and GD (LRE = 2.46 vs 2.27, <i>p</i> < 0.001). Snowballs (49 vs 69 mm, <i>p</i> < 0.01) and spoke (139 vs 171, <i>p</i> < 0.001) diameters were also reduced in the BLF condition.</p><p><strong>Conclusion: </strong>About 6% and 10% more light energy was needed to occlude the grating stimulus for GD and CC. Light spread measured using the two-point technique was about 26% less for the BLF. The BLF reduced snowballs and spokes by about 24% and 19%. The BLF significantly improved function across a variety of visual indices.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective Gamma-Secretase Inhibition by CHF5074 Attenuates Inflammation and Neovascularization in a Murine Model of Choroidal Neovascularization.","authors":"Fei Wang, Bohui Yang, Yuefeng Liao, Mingwei Zhao","doi":"10.1080/02713683.2024.2445656","DOIUrl":"10.1080/02713683.2024.2445656","url":null,"abstract":"<p><strong>Purpose: </strong>Chronic inflammation plays an important role in the pathogenesis of choroidal neovascularization (CNV). This study aimed to investigate the effect of the CHF5074, a γ-secretase inhibitor, on angiogenesis in a laser-induced CNV model and elucidate its possible molecular mechanism.</p><p><strong>Methods: </strong>Male C57/BL6J mice aged between 6 to 8 weeks were employed to set up a laser-induced model of CNV. Then, CHF5074 was injected intraperitoneally on the day after laser modeling, as well as on the second, third, and fourth days. Immunofluorescence staining was used to evaluate the retinal and choroidal complex. The markers used were CD31 for neovascularization and IBA1 for microglia staining in ocular tissue slices. Fundus fluorescein angiography on days 3d, 7d, and 14d analyzed neovascularization and leakage areas. Inflammatory indicators were examined by Western blot (WB) and enzyme-linked immunosorbent assay (ELISA). High-throughput whole-tissue sequencing of retinal choroids identified relevant cell pathways. Key regulatory factors modulated by CHF5074 were identified <i>via</i> WB. Co-culture of BV2 cells and human umbilical vein endothelial cells (HUVEC) were used to explore the function of CHF5074 on the inhibition of tube formation.</p><p><strong>Results: </strong>CHF5074 significantly decreased CD31 expression in the choroid on 3d, 7d, and 14d post-laser modeling (<i>p</i> < 0.05) and decreased both neovascularization and leakage areas (<i>p</i> < 0.05). Additionally, CHF5074 significantly lowered TNF-α, IL-10, and IL-1β expression levels in the choroid (<i>p</i> < 0.05), as demonstrated by WB analysis and ELISA. High-throughput whole-tissue sequencing identified P38-MAPK, JNK, and Wnt signaling pathways associated with neovascularization. CHF5074 decreased P38 protein phosphorylation (<i>p</i> < 0.05) as confirmed by WB analysis. CHF5074 inhibited the tube formation of HUVECs co-cultured with LPS and ATP-treated BV2 cells.</p><p><strong>Conclusion: </strong>CHF5074 significantly suppresses angiogenesis in laser-induced choroidal neovascularization models, suggesting its potential as a novel agent for preventing and treating CNV.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"420-430"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expression of PAX6 and Keratocyte-Characteristic Markers in Human Limbal Stromal Cells of Congenital Aniridia and Healthy Subjects, <i>In Vitro</i>.","authors":"Zhen Li, Tanja Stachon, Julia Zimmermann, Simon Trusen, Fabian N Fries, Maximilian Berger, Shweta Suiwal, Ning Chai, Berthold Seitz, Lei Shi, Maryam Amini, Nóra Szentmáry","doi":"10.1080/02713683.2025.2449915","DOIUrl":"10.1080/02713683.2025.2449915","url":null,"abstract":"<p><strong>Purpose: </strong>Our aim was to examine the expression of PAX6 and keratocyte-specific markers in human limbal stromal cells (LSCs) in congenital aniridia (AN) and in healthy corneas, <i>in vitro</i>.</p><p><strong>Methods: </strong>Primary human LSCs were extracted from individuals with aniridia (AN-LSCs) (<i>n</i> = 8) and from healthy corneas (LSCs) (<i>n</i> = 8). The cells were cultured in either normal-glucose serum-containing cell culture medium (NGSC-medium) or low-glucose serum-free cell culture medium (LGSF-medium). Analysis of PAX6 and keratocyte-specific markers was conducted using qPCR and Western blotting. The keratocyte-specific markers included Collagen I (COL1A1), Collagen III (COL3A1), Collagen V (COL5A1), α-smooth muscle actin (ACTA2), Aldehyde Dehydrogenase 3 Family, Member A1 (ALDH3A1), Keratocan (KER), Lumican (LUM), and CD34.</p><p><strong>Results: </strong><i>PAX6</i> mRNA expression exhibited a significant decrease in AN-LSCs compared to LSCs in both NGSC- and LGSF-medium (<i>p</i> = 0.04; <i>p</i> = 0.014). There was a marked reduction in <i>COL5A1</i> mRNA expression (<i>p</i> = 0.011), accompanied by notably higher <i>ALDH3A1</i> and <i>KER</i> mRNA levels (<i>p</i> = 0.007; <i>p</i> = 0.013) in AN-LSCs compared to LSCs when using NGSC-medium. In LGSF-medium, AN-LSCs showed a significant increase in <i>COL1A1</i> and <i>COL5A1</i> mRNA expression compared to LSCs (<i>p</i> = 0.048; <i>p</i> = 0.002). Moreover, COL1A1 and α-SMA protein expression were significantly elevated in AN-LSCs compared to LSCs in LGSF-medium (<i>p</i> = 0.048, <i>p</i> = 0.008).</p><p><strong>Conclusions: </strong>Our investigation affirms the altered expression of PAX6 and keratocyte-specific markers in AN-LSCs relative to healthy controls. Both NGSC- and LGSF-medium exerted distinct effects on both LSCs and AN-LSCs. The observed variations in PAX6 and keratocyte-specific marker expression in AN-LSCs may play a pivotal role in the development and progression of aniridia-associated keratopathy.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"362-372"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142946274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/02713683.2025.2472506","DOIUrl":"10.1080/02713683.2025.2472506","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"460"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Targeting CCL5 Attenuates Fibrosis via Activation of PI3k/Akt Signaling Axis After Glaucoma Filtration Surgery.","authors":"Baixue Zhu, Ran Wei, Xinying Li, Qingyun Bi","doi":"10.1080/02713683.2024.2432399","DOIUrl":"10.1080/02713683.2024.2432399","url":null,"abstract":"<p><strong>Purpose: </strong>Glaucoma filtration surgery (GFS) stands as a paramount clinical intervention for glaucoma. Nonetheless, the prevalent cause of GFS failure is filtration bleb scarring, and the role of inflammation and immune response in contributing to fibrosis remains elusive.</p><p><strong>Methods: </strong>The study employed 30 female Sprague-Dawley rats (8 weeks old, 200-250 g) to assess the anti-scarring impact of the Chemokine (C-C motif) receptor 5 (CCR5)-Chemokine (C-C motif) ligand 5 (CCL5) antibody after GFS. Additionally, anti-fibrotic effects on HConFs were examined, creating an intra-operative inflammatory response using damaged-HConFs supernatant medium (DHSM). <i>In vitro</i> and <i>in vivo</i> validation aimed to elucidate the potential anti-fibrotic molecular mechanism of the CCR5-CCL5 antibody.</p><p><strong>Results: </strong>The CCR5-CCL5 antibody effectively prolonged filtration bleb duration and enhanced the functionality of the filtered bleb. Improved postoperative intraocular pressure values (IOP) and morphological images were observed in the CCR5-CCL5 antibody-treated group. Histochemical staining and cellular experiments confirmed the antifibrotic function of the CCR5-CCL5 antibody. Notably, M2-type macrophage polarization was reduced in the CCR5-CCL5 antibody-treated model. CCL5-induced fibrosis in HConFs was mediated through the PI3K/Akt signaling pathway. Consistently, inhibition of PI3K/Akt significantly attenuated the profibrotic effects of CCR5-CCL5. Mechanistically, the CCL5 antibody exerts its antifibrotic effect by targeting CCR5 on HConFs, leading to the inhibition of the PI3K/Akt mechanism.</p><p><strong>Conclusions: </strong>This study unveils that CCR5-CCL5 promotes fibrosis in GFS through inflammatory stimulation of HConFs and enhanced activation of the PI3K/Akt signaling pathway. The findings suggest that intraoperative CCR5-CCL5 antibody treatment could serve as a cost-effective therapeutic agent or a useful adjuvant in preventing ocular bleb scar formation.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"394-404"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142767022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Computed Tomography - Dacryocystography Guided Management of Traumatic Secondary Acquired Lacrimal Duct Obstruction: SALDO Update Study (SUP) - Paper V.","authors":"Ayushi Agarwal, Mohammad Javed Ali, Nandini Bothra","doi":"10.1080/02713683.2025.2452914","DOIUrl":"10.1080/02713683.2025.2452914","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the role of computed tomography-dacryocystography (CT-DCG) in the management of traumatic secondary acquired lacrimal duct obstruction (SALDO) and study its correlation with the intra-operative findings.</p><p><strong>Methods: </strong>Retrospective interventional case series. Eighty-five lacrimal drainage systems (LDS) of 79 patients diagnosed with traumatic SALDO, who underwent pre-operative CT-DCG, between January 2019 and June 2023, were analyzed. The lacrimal intervention included endoscopic dacryocystorhinostomy (En-DCR), external DCR(Ex-DCR), or dacryocystectomy (DCT) based on the clinical presentation, CT-DCG findings, local and systemic factors. Anatomical and functional outcomes were assessed.</p><p><strong>Results: </strong>Eighty-five LDS of 79 patients with a mean age of 32 years and male predominance (<i>n</i> = 70, 89%) were studied. The median time of trauma to clinical presentation was 12 months and the duration of epiphora was 8 months. Naso-orbito-ethmoid fractures were seen in 56 (66%) cases and cribriform plate fracture in 5 (6%) patients. CT-DCG revealed a dilated sac in 60 (71%) LDS, shrunken in 13 (15%), while the sac could not be visualized in 3 (4%) LDS. Relative lacrimal sac displacement was seen in 51 (64%) LDS of which 21 (41%) were displaced posteriorly, 18 (35%) superiorly, 5 (10%) inferiorly, and 8 (16%) into the anterior orbit. Sac - duct junction was the most common location of obstruction (<i>n</i> = 78, 92%). At a mean follow up period of 3.5 months, 62 of the 63 LDS surgeries performed (98%) demonstrated anatomical and functional success. Of the 63 operated LDS, CT-DCG findings corroborated with intra-operative findings in 60 (95%) LDS.</p><p><strong>Conclusion: </strong>CT-DCG helps decide the surgical approach, possible complications, intra-operative course and hence has the potential to influence the outcomes. A thorough understanding of CT-DCG, therefore, should be a part of a Dacryologist's armamentarium for managing complex SALDO.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"454-459"},"PeriodicalIF":1.7,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}