Current Eye Research最新文献

{"title":"Comparison of Optic Nerve, Macula, and Choroidal Parameters in Newly Diagnosed Migraine Patients and Healthy Controls.","authors":"Yusa Bulent Kisaboy, Pinar Orenc, Hulya Gungel, Cagla Sisman","doi":"10.1080/02713683.2025.2536583","DOIUrl":"10.1080/02713683.2025.2536583","url":null,"abstract":"<p><strong>Purpose: </strong>Retinal vascular occlusion, ischemic optic neuropathy, and normotensive glaucoma have been found to be associated with migraine in several studies. By examining the optic nerve, macula, and choroid of newly diagnosed migraine (NDM) patients, this study aims to investigate possible early changes in these structures, thus guiding both the diagnosis and treatment of migraine.</p><p><strong>Methods: </strong>Forty-one (82 eyes) NDM patients and 41 (82 eyes) healthy controls (HC) were enrolled in this prospective cohort study. Participants were divided into two groups, the NDM group and the HC group, and optic nerve, macula, and choroid structures were prospectively examined and compared with both intra-group and inter-group comparison methods.</p><p><strong>Results: </strong>In the inter-group comparison performed by using Generalized Estimating Equations analysis, all Retinal Nerve Fiber Layer Thickness (RNFL) parameters were statistically significantly lower in the NDM group compared to the HC group (<i>p</i> < 0.05). Regarding the ganglion cell complex (GCC) and choroidal parameters, statistically significant differences were found between the two groups in all parameters except for choroidal thickness (CT). In the NDM intra-group comparison, temporal RNFL, temporal-upper RNFL, and temporal-lower RNFL values of the right eye (RE) were significantly lower than the left eye (LE); nasal RNFL, nasal upper RNFL, and nasal lower RNFL values of the LE were significantly lower than the RE (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>Statistically significant values in RNFL, GCC, and choroid in the NDM group indicate the possible early changes in optic nerve, macula, and choroid in NDM patients. In intra-NDM group comparison, lower values of the temporal RNFL sectors in the RE and nasal RNFL sectors in the LE may suggest the involvement of the lateral geniculate nucleus in migraine.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1147-1154"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing a Novel Motorized Push-Up Ruler with Conventional Subjective Methods for Measuring the Amplitude of Accommodation.","authors":"Sven Schumayer, Jona Laukhuf, Torsten Straßer","doi":"10.1080/02713683.2025.2531524","DOIUrl":"10.1080/02713683.2025.2531524","url":null,"abstract":"<p><strong>Purpose: </strong>Determination of the amplitude of accommodation (AoA) is a clinical technique used in ophthalmology and optometry to assess the eye's ability to focus on near objects. This study compares the reliability of a novel motorized push-up variant with conventional manual push-up and push-down methods for the determination of AoA in 26 emmetropes.</p><p><strong>Methods: </strong>The motorized push-up method reduces limitations of the manual methods, such as differences due to varying examiner abilities, ruler placement (forehead, zygomatic bone, spectacle plane), and inconsistent target movement speeds. This is achieved by providing a participant-controlled, constant target movement of 2 cm/s, with the medial zone of the zygomatic bone as the reference point for ruler placement. Additionally, digital image-based and traditional ruler-based AoA measurements were compared. The participants' impressions of the three methods were assessed based on ease of use, confidence in measurement reliability, and comfort of experience, using a questionnaire.</p><p><strong>Results: </strong>The comparison of the AoA across the methods revealed no statistically significant differences. However, the concordance correlation coefficient was highest between the motorized and manual push-up method (ρ_c = 0.72). All methods showed good test-retest reliability with the highest ICC found for the motorized push-up method (0.83), which also had the narrowest limits of agreement interval for accommodative demand (3.22 cm). Beyond digital and ruler-based measurements showed underestimation by both rulers, with a mean bias of 0.3 cm for the motorized ruler compared to about 2.0 cm for the conventional ruler. The questionnaire responses suggest that the motorized version outperforms the manual versions being 5 times more likely to score higher for ease of use and 6 times more likely for confidence in measurement reliability.</p><p><strong>Conclusion: </strong>These findings demonstrate that the motorized push-up method effectively measures the AoA, reduces interfering factors, and provides higher reliability without compromising precision, making it a valuable alternative to conventional methods.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1164-1172"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Short-Term Color Vision Perception Changes After Using a Repeated Low-Level Red-Light Therapy Myopia Management Device.","authors":"Baasimah Batool, Christopher Davey, Annegret Dahlmann-Noor, Declan Mckeefry, Neema Ghorbani-Mojarrad","doi":"10.1080/02713683.2025.2523912","DOIUrl":"10.1080/02713683.2025.2523912","url":null,"abstract":"<p><strong>Purpose: </strong>Repeated low-level red-light (RLRL) therapy is an emerging technique for managing myopia progression. Clinical trials have demonstrated its efficacy, but uncertainties remain on its effect on immediate vision perception. This study evaluated the impact of RLRL on short-term color vision perception and choroidal thickness. Attitudes towards RLRL were also explored.</p><p><strong>Methods: </strong>Twenty participants underwent color vision assessment using the Colour Assessment Diagnosis (CAD) test and macular optical coherence tomography (OCT) to determine their eligibility and establish baseline measures for color vision perception threshold and choroidal thickness, with color vision perception measured using chromatic displacement (CD). Participants then underwent three sessions of RLRL, at the required time intervals as per manufacturer guidance. After each session, the CAD test was performed immediately, and repeated after a 5-minute interval. At the final visit, the OCT scan was retaken, and participants were asked about their experience of using RLRL. CD was measured and compared before and after RLRL exposure, to identify if there was any differences following usage.</p><p><strong>Results: </strong>A significant reduction in color perception sensitivity was observed immediately after exposure to RLRL at each visit (<i>p</i> < 0.001 for all), which returned to baseline levels after 5 min. Three sessions of RLRL caused no change compared to baseline color perception (<i>p</i> = 0.054). There was no significant difference in the mean choroidal thickness in the left eye; the right eye showed a small reduction in macular choroidal thickness 5.1 µm (± 8.551 µm SD, <i>p</i> = 0.015). Participant feedback demonstrated a generally positive response, indicating people would consider using RLRL for myopia management if recommended.</p><p><strong>Conclusions: </strong>There appears to be only a temporary impact of RLRL on color vision perception, which returns to baseline after 5 min. Furthermore, feedback suggests that UK populations may be receptive to RLRL if prescribed to them by an eye care practitioner.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1173-1180"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144574985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monitoring the Evolution of Dry Eye Disease in Rabbits with Advanced Ocular Keratography: Implications for Translational Studies.","authors":"Nicholas Fazio, Emily White, Konstantinos Tourmouzis, Brian Wollocko, Michael Wolek, Ishan Amin Khwaja, Barbara Nemesure, Kevin Kaplowitz, Timothy Chou, Liqun Huang, Basil Rigas, Robert Honkanen","doi":"10.1080/02713683.2025.2527726","DOIUrl":"10.1080/02713683.2025.2527726","url":null,"abstract":"<p><strong>Purpose: </strong>Experimental studies of Dry Eye Disease (DED) using animal models are hampered by the lack of reliable, easy-to-use assays that can adequately diagnose disease or monitor effects of novel treatments. The Oculus Keratograph 5 M, an advanced keratography unit (AKU), has shown promise, enjoying recent clinical use. We assessed whether this AKU could be used in DED studies in the rabbit, perhaps the ideal experimental animal for this disease.</p><p><strong>Methods: </strong>All measures were made in strictly controlled temperature and humidity spaces. A panel of AKU parameters was measured in 15 New Zealand White rabbits at baseline, after Concanavalin A induced DED, and following recovery. Eyelid aperture and corneal irregularity were also measured. A subset of these parameters was measured in patients and compared with those from rabbits.</p><p><strong>Results: </strong>AKU parameters in both humans and rabbits showed similar patterns and coefficients of variation (CV). Measurements of tear and eyelid architecture were more reproducible than tear film function in both species. The CV for most parameters were less than the observed changes in the respective parameters after DED induction. In rabbits, all parameters improved returning close to baseline following DED recovery. In the rabbit, additional measures (eyelid aperture and corneal irregularity) not traditionally associated with DED, also demonstrated changes that evolved over the development and recovery of DED.</p><p><strong>Conclusions: </strong>AKU technology can effectively detect changes in multiple parameters during the evolution and resolution of DED in rabbits. DED parameters showed similar patterns for most variables in both humans and rabbits demonstrating great potential of this device in translational research. The AKU can also follow additional parameters evaluating the responses of the lacrimal functional unit. Our findings document the applicability of this technology for translational studies of DED and underscores its potential to further refine understanding of the disease pathophysiology.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1094-1104"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcriptome Sequencing Reveals ceRNA Networks and Molecular Signatures in Myopic Mouse Retina.","authors":"Xueting Wang, Huiman Zhuang, Yalong Dang, Fang Lei","doi":"10.1080/02713683.2025.2541448","DOIUrl":"10.1080/02713683.2025.2541448","url":null,"abstract":"<p><strong>Purpose: </strong>Long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) in the retina play crucial roles in myopia; however, their regulatory mechanisms remain unclear. This study aimed to investigate significant genes and related signaling pathways associated with myopia by constructing and analyzing competitive endogenous RNA (ceRNA) networks within the retina.</p><p><strong>Materials and methods: </strong>We investigated the expression patterns of lncRNAs, circRNAs, microRNAs (miRNAs), and messenger RNAs (mRNAs) within the retina using a form-deprivation myopia mouse model to elucidate their regulatory mechanisms in myopia. Transcriptomic sequencing was performed on retinal cells obtained from a mouse myopia model, followed by differential expression and functional enrichment analyses. Relevant ceRNA networks (lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA) were constructed. Key pathways in these networks were validated <i>via</i> quantitative real-time polymerase chain reaction and western blotting, while Immunohistochemistry and single-cell sequencing analyses were conducted to analyze significant gene distribution.</p><p><strong>Results: </strong>The model exhibited approximately -6D diopters after 14 days of form deprivation. Transcriptomic analysis identified 187 differentially expressed lncRNAs (DE lncRNAs), 22 DE circRNAs, 24 DE miRNAs, and 368 DE mRNAs. Enrichment analysis linked these differentially expressed genes to various retinal functions and pathways. Validation revealed that the TCONS_00102163-mmu-miR-540-3p-Kcnq2, TCONS_00127926-novel_234-Tepp, and novel_circ_0001750-mmu-miR-212-5p-Sstr3 pathways in the retina were involved in regulating myopia. All experiments were conducted in three independent biological replicates.</p><p><p><b>Conclusions:</b> This study systematically elucidated the synergistic regulatory mechanisms of non-coding RNAs in the development of myopia by constructing a ceRNA regulatory network in the retina, and further validated key regulatory axes. This provides an important theoretical foundation for understanding the molecular mechanisms of myopia and developing novel intervention strategies.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1181-1194"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Age-Related Changes in Human Lens Stiffness Through a Novel Non-Invasive Method Using Shear Wave Ultrasound Elastography.","authors":"Alaa Hussein Qader, Norafida Binti Bahari, Ezamin Bin Abdul Rahim, Rafidah Binti Md Saleh, Muhsonat Binti Mohamad Zain, Amanj Kurdi","doi":"10.1080/02713683.2025.2535738","DOIUrl":"10.1080/02713683.2025.2535738","url":null,"abstract":"<p><strong>Purpose: </strong>Presbyopia is an age-related condition characterized by diminished near-vision, primarily due to changes in the lens' adaptive capacity. Shear Wave Ultrasound Elastography (SWE) offers a novel/noninvasive method to measure lens stiffness and could potentially enhance our understanding of presbyopia's development. We aimed to use SWE to assess the elasticity of the human lens and explore the correlation between lens flexibility, age, presbyopia, and accommodation capacity.</p><p><strong>Methods: </strong>A cross-sectional analysis was conducted with 84 participants (mean age = 39.61 ± 9.60) from a government hospital in Serdang, Selangor, Malaysia. Eligibility was confirmed through refractive error and visual acuity tests. Selected participants underwent SWE scanning, and measurements of accommodation and presbyopia were taken. Statistical analysis included descriptive summaries and Pearson correlation coefficients to examine relationships between lens elasticity age, presbyopia, and amplitude of accommodation.</p><p><strong>Results: </strong>The analysis demonstrated a weak correlation between lens elasticity and age in nonpresbyopic group (<i>r</i> = 0.289) while positive strong correlation in presbyopic group (<i>r</i> = 0.674). A strong positive correlation was observed between lens elasticity and presbyopia in presbyopic group (<i>r</i> = 0.612). Moreover, there was a negative correlation with accommodation in both groups, (r = -0.358) for nonpresbyopic and (r = -0.493) presbyopic group.</p><p><strong>Conclusions: </strong>While lens elasticity diminishes with age, changes in ocular biomechanical properties impact lens function, particularly affecting near vision. Importantly, SWE is found to be an effective tool for assessing age-related changes in lens elasticity and presbyopia across various age groups, highlighting its potential for broader clinical application in diagnosing and understanding presbyopia.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1112-1122"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterizing Retinal Mitochondrial Function and Its Relations to Intraretinal Thicknesses in Healthy Adults.","authors":"Colin K Kim, Giovana R Gameiro, Ava-Gaye Simms, Byron L Lam, Collin A Rich, Jianhua Wang, Hong Jiang","doi":"10.1080/02713683.2025.2527755","DOIUrl":"10.1080/02713683.2025.2527755","url":null,"abstract":"<p><strong>Purpose: </strong>To characterize retinal mitochondrial function and its relationship with intraretinal thicknesses in healthy adults.</p><p><strong>Methods: </strong>Retinal flavoprotein fluorescence (FPF), a marker of mitochondrial function, was measured using the OcuMet Beacon (OcuSciences, Inc., Ann Arbor, MI), and a stress index (SI) was computed using Enhanced Retinal Metabolic Analysis software 2.0 (RMA). After lens compensation, mean FPF in the macula and optic nerve head (ONH) was obtained. The macular SI summarizes FPF heterogeneity, while the ONH SI reflects the extent to which ONH FPF exceeds a normative threshold. Intraretinal layer thicknesses and total retinal thickness (TRT) were measured <i>via</i> spectral-domain OCT (AngioVue, Optovue, Inc., ver. 2018.1.0.43) using 6 x 6 mm macular scans. A total of 75 healthy adults (mean age ± SD: 56.1 ± 21.7 years; range: 23-89) were imaged.</p><p><strong>Results: </strong>Macular and ONH FPF were inversely correlated with TRT (<i>p</i> < 0.01), retinal nerve fiber layer (RNFL) thickness (<i>p</i> < 0.05), and ganglion cell-inner plexiform layer (GCIPL) thickness (<i>p</i> < 0.01). ONH FPF also showed a negative correlation with the thickness of the OPL-EZ region-defined as the area between the posterior boundary of the outer plexiform layer (OPL) and the anterior boundary of the ellipsoid zone (EZ) (r = -0.24, <i>p</i> = 0.044)-and the photoreceptor layer (PR) (r = -0.34, <i>p</i> = 0.003). Age was significantly associated with FPF and with several intraretinal layer thicknesses, including TRT, RNFL, GCIPL, OPL-EZ region, and PR (all <i>p</i> < 0.05). However, after adjusting for age, associations between FPF and intraretinal thicknesses were no longer significant (all <i>p</i> > 0.05).</p><p><strong>Conclusion: </strong>This study is the first to examine the relationship between retinal mitochondrial function and intraretinal layer thicknesses in healthy adults. Findings suggest that age mediates the observed associations.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1131-1138"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12313233/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144590634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Assessment of Choriocapillaris Blood Flow in Diabetic Retinopathy Using Optical Coherence Tomography Angiography.","authors":"Binzhe Fu, Jiajia Liu, Sheng Wang, Shuxian Feng, Yining Dai, Rong Liu, Wenliang Chen, Chen Xi Li","doi":"10.1080/02713683.2025.2537284","DOIUrl":"10.1080/02713683.2025.2537284","url":null,"abstract":"<p><strong>Purpose: </strong>To develop an automated method for segmenting and quantifying the choriocapillaris (CC) layer using swept-source optical coherence tomography angiography (SS-OCTA), aimed at evaluating CC perfusion changes in diabetic retinopathy (DR) patients and facilitating clinical research.</p><p><strong>Methods: </strong>We proposed a traditional image processing algorithm combining shadow compensation and intensity gradients to segment the CC layer in eyes at various stages of DR. The algorithm was refined for artifact removal in CC blood flow analysis. It was tested on 25 manually segmented cases including normal eyes, non-proliferative diabetic retinopathy (NPDR), and proliferative diabetic retinopathy (PDR). CC blood flow quantification was performed on 69 subjects.</p><p><strong>Results: </strong>The segmentation algorithm showed high accuracy, with a maximum mean positional error of 4.086 ± 4.304 μm for Bruch's membrane (BM) and a minimum average DICE coefficient of 0.831 for CC segmentation. The CC flow deficit percentage (FD%) for normal eyes, NPDR eyes, and PDR eyes were 9.79 ± 2.29%, 12.25 ± 3.89%, and 15.35 ± 4.00%, respectively, with significant differences between groups (<i>p</i> < 0.05).</p><p><strong>Conclusions: </strong>The automated CC segmentation and quantification algorithm developed in this study provides an accurate and reliable method for assessing CC in DR patients. This method has potential for widespread clinical application in evaluating CC perfusion changes across various stages of DR.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1155-1163"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706611","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observation of Soft Contact Lens-Related Meibomian Gland Abnormalities Before Corneal Refractive Surgery.","authors":"Le Tian, Dewei Li, Feifei Zhang, Yi Song, Luqin Wan, Mingming Zhou, Min Chen","doi":"10.1080/02713683.2025.2537291","DOIUrl":"10.1080/02713683.2025.2537291","url":null,"abstract":"<p><strong>Purpose: </strong>By observing the dry eye index, meibomian glands (MGs), corneal dendritic cells (DCs) and nerve fiber density (CNFD) in patients who have been wearing soft contact lenses continuously and those who have stopped wearing them before corneal refractive surgery, analyze the characteristics of soft contact lens-related MGs abnormalities.</p><p><strong>Methods: </strong>Collected patient datas and divided into a control group, a wearing group and a stop wearing group. All patients underwent oculus keratography examination, the wearing and the stop wearing group underwent confocal microscopy examination.</p><p><strong>Results: </strong>The MGs defect rate and the number of obstructive MGs in the wearing group were significantly higher than those in the stopping group (<i>p</i> < 0.01). The MG scores of the wearing group were significantly higher than those of the control group (<i>p</i> < 0.01). The wearing group had an increase in DCs and a decrease in central CNDF compared to the stopping group (<i>p</i> < 0.01). The duration of continual use of contact lenses correlated with the MGs defect rate and the number of obstructive MGs(<i>p</i> < 0.05). The length of time since discontinuation correlated with the number of obstructive MGs, central DCs density, and central CNFD(<i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>Long term continuous wearing of soft contact lenses leads to MGs abnormalities, and DCs increased in all directions of the cornea, CNFD decreased in the central area of the cornea. There were immune and neurological factors involved in soft contact lens-related MGs abnormalities in middle-aged and young people, and the severity varies among individuals. When stopped wearing soft contact lenses exceed one week, the morphological changes of MGs occured earlier.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1105-1111"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144759400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alabama Screening and Intervention for Glaucoma and Eye Health Through Telemedicine (AL-SIGHT): The Impact of Financial Incentives on Health Care Engagement Following Telemedicine-Based Vision Screening.","authors":"Christopher Girkin, Poojitha Balakrishnan, Liyan Gao, Gerald McGwin, Lindsay Rhodes, Cynthia Owsley","doi":"10.1080/02713683.2025.2535731","DOIUrl":"10.1080/02713683.2025.2535731","url":null,"abstract":"<p><strong>Purpose: </strong>Financial incentives have proven successful in addressing health behaviors associated with several chronic diseases and may represent a potential method to improve adherence to follow-up eye examinations from vision screening programs. The study was conducted to determine the effect of financial incentives on follow-up adherence in the Alabama Screening and Intervention for Glaucoma and eye Health through Telemedicine.</p><p><strong>Methods: </strong>This study enrolled eligible patients receiving care at three Federally Qualified Health Centers to undergo screening for refractive error and ocular diseases. Follow-up appointments for continued care were made for patients suspected to have uncorrected refractive error or ocular disease. A subset of patients (<i>n</i> = 187) received a financial incentive while a control group did not (<i>n</i> = 234). Follow-up attendance within 6 months was compared with Poisson's models between incentivized and non-incentivized groups for all referrals and across specific disease states.</p><p><strong>Results: </strong>Among 187 patients with and 234 without incentive, there was a significantly higher rates of follow-up in the incentivized group (83.4% incentivized vs. 74.4% non-incentivized, <i>p</i> = .05) overall. There was a significantly higher rate of attendance for patients referred for diabetic retinopathy (<i>p</i> = .02) and refractive error (<i>p</i> = .02), but not glaucoma (<i>p</i> = .46), glaucoma suspect (<i>p</i> = .70), ocular hypertension (<i>p</i> = .22), and cataract (<i>p</i> = .29). After matching across groups, these differences were less pronounced and only remained significant for diabetic retinopathy (<i>p</i> = .04).</p><p><strong>Conclusion: </strong>Patients receiving financial incentive had a higher follow-up rate within 6 months. These differences where primarily driven by patients referred for refractive error and diabetic retinopathy. However, once matched for baseline covariates, this improvement was not seen in the overall group. This suggests that incentives may not be an effective method to improve adherence to vision screening in this setting especially for glaucoma screening.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1123-1130"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}