Current Eye Research最新文献

{"title":"SERPINA3 in Diabetic Retinopathy: A Pilot Study Assessing the Impact of Prior COVID-19 Infection on Patients.","authors":"Arthur Miller, Eunheh Koh, Rebekah Robinson, Vikas Kumar, Ashok Sharma, Shruti Sharma","doi":"10.1080/02713683.2025.2494795","DOIUrl":"https://doi.org/10.1080/02713683.2025.2494795","url":null,"abstract":"<p><strong>Purpose: </strong>SERine Protease INhibitor clade A member 3 (SERPINA3), a protease inhibitor involved in the acute phase response, is regulated by interleukin 6 trans-signaling, a pro-inflammatory pathway associated with diabetic retinopathy (DR) pathogenesis. We hypothesized that SERPINA3 may serve as a biomarker to distinguish DR patients from diabetic patients without retinopathy.</p><p><strong>Methods: </strong>We measured serum SERPINA3 levels in DR patients and demographically matched diabetic patients without retinopathy to assess the biomarker potential of SERPINA3. History of COVID-19 infection was included as a demographic variable.</p><p><strong>Results: </strong>Our results showed that SERPINA3 levels did not vary between cases and controls, nor was there any correlation with disease severity as measured by hemoglobin A1c and diabetic retinopathy stage. We found that excluding patients with a history of COVID-19 infection increased the predictive value of SERPINA3, and that SERPINA3 levels were significantly increased in those subjects hospitalized due to COVID-19. The predictive value of SERPINA3 for hospitalization was similar to age, duration of diabetes, and HbA1c in our cohort.</p><p><strong>Conclusions: </strong>Overall, SERPINA3 had poor sensitivity and specificity for identifying DR patients, and COVID-19 infection history significantly increased variance in SERPINA3 levels. Further investigation into the potential of SERPINA3 as DR biomarker should be sufficiently powered to account for the potentially confounding effects of COVID-19 infection.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Haptic Design, Passing Direction, and Inter-Flange Distance on the Position of the Intraocular Lens during 4-Flanged Intrascleral Fixation.","authors":"Jong Hwa Jun, Seung Pil Bang, Kyu Young Shim, Alexander C Lieu, Natalie A Afshari","doi":"10.1080/02713683.2025.2495218","DOIUrl":"https://doi.org/10.1080/02713683.2025.2495218","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to investigate the effect of haptic design, direction of suture passage, and distance between flanges on the haptic-iris distance after four-flanged scleral fixation of a single-piece intraocular lens with four eyelets.</p><p><strong>Methods: </strong>After marking the 3 and 9 o'clock positions on the limbus, each 26-G needle was positioned 2.0 mm posterior to the limbus and passed 2.0, 3.0, and 4.0 mm away from the markings at 3 o'clock and 9 o'clock, respectively. We passed each end of a 5-0 polypropylene suture anteroposteriorly or posteroanteriorly through two unilateral eyelets. The haptic-iris distance was evaluated using anterior-segment optical coherence tomography.</p><p><strong>Results: </strong>Passing the suture through the eyelets in the posteroanterior direction yielded a wider haptic-iris distance than that achieved by passing the suture in the anteroposterior direction (<i>p</i> < 0.001, respectively). A wider distance between the polypropylene flanges correlated with reduced distortion of haptic structures. Fixation of the Akreos AO with a 4.0-mm suture spacing induced a wider haptic-iris distance (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>Passing sutures through the eyelet in the posteroanterior direction during intrascleral fixation proved to be more effective in securing a sufficient haptic-iris distance. A wider distance between flanges was beneficial in preventing structural distortion of the haptic and ensuring a proper distance between the haptic and iris.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143958238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Epithelial Changes in Eyes with Post-Traumatic Recurrent Corneal Erosion: Comparison with Fellow Eyes and Healthy Controls.","authors":"Ritika Mukhija, Rachana P Shah, Issac Levy, Mayank A Nanavaty","doi":"10.1080/02713683.2025.2503209","DOIUrl":"https://doi.org/10.1080/02713683.2025.2503209","url":null,"abstract":"<p><strong>Purpose: </strong>To assess corneal epithelial thickness (ET) changes in affected and fellow eyes of patients with post-traumatic recurrent corneal erosions (RCE) and compare these with healthy age-matched controls.</p><p><strong>Methods: </strong>This is a single-centre observational study involving retrospective data collection for patients presenting with traumatic RCE. ET maps were obtained at the follow-up visit once the erosion had healed. Data was recorded for affected (Group 1) and fellow eyes (Group 2) and for healthy age-matched control eyes (Group 3). The primary outcome measure was comparison of \"E-Std Dev\" values (variation in ET maps between the three groups). Secondary outcome measures were central ET, minimum ET, maximum ET, superior ET, inferior ET and E(min-max) values, and qualitative map assessment, which was performed by analysing the number of zones with thicknesses 60-70 µ and 70-80 µ.</p><p><strong>Results: </strong>Thirty-three patients (66 eyes) and 33 age-matched healthy eyes were included. E-Std Dev values were highest values in Group 1 and lowest in Group 3 (4.65 ± 1.87 µ, 2.92 ± 1.16 µ and 1.94 ± 0.63 µ in Groups 1, 2 and 3 respectively) (<i>p</i> < 0.01). A similar trend was also noted for central ET (<i>p</i> < 0.01), maximum ET (<i>p</i> < 0.01), E(min-max) values (<i>p</i> = 0.03) and qualitative map assessment (<i>p</i> < 0.01). There were no significant inter-group differences for minimum ET (<i>p</i> = 0.05), superior ET {E-S (2-7)} (<i>p</i> = 0.45) and inferior ET {E-I (2-7)} (<i>p</i> = 0.68).</p><p><strong>Conclusions: </strong>Variation and maximum ET were highest in the affected eyes. Even the fellow eyes showed higher values than healthy controls. This may suggest a predisposition of some patients to develop RCE after trauma.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143972878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blue Light Irradiation Elicits Senescence of Corneal Endothelial Cells <i>In Vitro</i> by Provoking Energy Crisis, Inflammasome Assembly and DNA Damage.","authors":"Xin Zheng, Guo-Jian Jiang, Ting-Jun Fan","doi":"10.1080/02713683.2025.2497330","DOIUrl":"https://doi.org/10.1080/02713683.2025.2497330","url":null,"abstract":"<p><strong>Purpose: </strong>The blue light from the digital screens endangers the visual system among which the corneas at the outmost of eyes are vulnerable to the irradiation. Therein, the human corneal endothelial (HCE) cells are crucial to maintain corneal transparency and their damage leads to HCE decompensation resulting in blindness ultimately. Thus, understanding the phototoxic effects of the blue light on the HCE cells and the underlying mechanisms is important for taking measures to protect the vision clarity from the blue-light hazard.</p><p><strong>Methods: </strong>We pulse-irradiated the HCE cell line cells at logarithmic phase for 3 passages using 440 nm blue light and examined the levels of reactive oxygen species (ROS), ATP, nicotinamide adenine dinucleotide (NAD⁺) and autophagy using cytochemistry assay to investigate the alterations of energy metabolism. Moreover, we examined the γH2AX⁺ cells using immunofluorescence and expression of poly(ADP-Ribose)polymerase1 (PARP1) using western blotting to investigate the degrees of DNA damage and repair. We also monitored the levels of inflammasome using western blotting and senescence associated secretory phenotypes (SASPs) of interleukin (IL)-8, IL-1β and IL-6 using qPCR and ELISA to investigate the inflammasome assembly and secretion of SASPs. We detected the senescent features with senescence-associated-β-galactosidase assay, p16 levels by western blotting, Lamin B1 localization by immunofluorescence observation, cell growth by EdU incorporation assay and confluence forming time and alterations of the cell morphology and relative areas by microscopy observation.</p><p><strong>Results: </strong>The HCE cells exhibited senescent features after blue-light-pulse-irradiation. The blue light provokes overproduction of ROS to decrease the levels of ATP, NAD⁺ and autophagy leading to energy crisis. Moreover, the excess ROS injure DNA and downregulate PARP1 resulting in stable cell-cycle arrest. The excess ROS also facilitate inflammasome assembly leading to hypersecretion of SASPs.</p><p><strong>Conclusion: </strong>The blue light elicits HCE cell senescence <i>via</i> inducing energy crisis, stable cell-cycle arrest and SASP hypersecretion.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-12"},"PeriodicalIF":1.7,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinol Binding Protein-4 and Galectin-3 Levels in Type II Diabetes: Their Impact on Retinopathy Risk.","authors":"Rajendran Sharmila, Dhanashree Ratra, Lawrence D Cruze, Reddy Prashanth, Saravana Kumar, Gopalan Sowmya, P Ravi Shankar, Ramasamy Magesh, Annamalai Radha, Kuppan Kaviarasan","doi":"10.1080/02713683.2025.2498029","DOIUrl":"https://doi.org/10.1080/02713683.2025.2498029","url":null,"abstract":"<p><strong>Purpose: </strong>Retinol binding protein-4, a lipocalin family member, and galectin-3, a lectin family member, link their potential role in modulating glucose metabolism and inflammation. This study aims to explore retinol binding protein-4 and galectin-3's role as the disease progresses from prediabetes to diabetic retinopathy and to ascertain whether these variables could serve as risk or diagnostic indicators for diabetic retinopathy.</p><p><strong>Methods: </strong>This study includes 100 patients divided into three groups, diabetic retinopathy (<i>n</i> = 39), type 2 diabetes mellitus (<i>n</i> = 41), and prediabetes (<i>n</i> = 21), based on inclusion and exclusion criteria. Serum levels of retinol binding protein-4 and galectin-3 were assessed by sandwich ELISA. Immunofluorescence analysis was employed to localize retinol binding protein-4 and galectin-3 in the retinal layers. The increase in serum retinol binding protein-4 levels was validated by quantitative western blot analysis. The HDOCK tool was used to identify the protein-protein interactions between retinol binding protein-4 and VEGF.</p><p><strong>Results: </strong>Serum retinol binding protein-4 levels were higher in diabetic retinopathy and type 2 diabetes mellitus compared to prediabetes (<i>p</i> < 0.0001). Further, western blot analysis confirmed a significant twofold increase in diabetic retinopathy compared to the prediabetes groups (<i>p</i> = 0.0423). Serum galectin-3 levels were insignificantly higher in diabetic retinopathy and type 2 diabetes mellitus when compared to prediabetes. The receiver operating characteristic curve analysis, the area under the curve values, also indicates that serum retinol binding protein-4 had acceptable performance (area under the curve: 0.7965 and 0.9007) for the comparison between prediabetes vs. type 2 diabetes mellitus and prediabetes vs. diabetic retinopathy, respectively, as compared to serum galectin-3 (area under the curve: 0.6961 and 0.7008). In the IF analysis, retinol binding protein-4 localization was more common in the photoreceptor region and the retina vessels, whereas galectin-3 was distributed in the ganglion cell layer of the retina. The strong binding between retinol binding protein-4 and the VEGFA and VEGFB isoforms was observed during the protein-protein interaction study.</p><p><strong>Conclusion: </strong>This study reveals that retinol binding protein-4 seems to be a diagnostic marker for diabetic retinopathy, which requires further investigation.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Topical Netarsudil in Childhood Glaucoma: A Systematic Review.","authors":"Omar Shaikh, Lana Kuziez, Osamah J Saeedi, Javaneh Abbasian, Abdelrahman M Elhusseiny","doi":"10.1080/02713683.2024.2445622","DOIUrl":"10.1080/02713683.2024.2445622","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effectiveness and safety of topical netarsudil 0.02% in managing childhood glaucoma.</p><p><strong>Methods: </strong>A literature search in the electronic databases of PubMed CENTRAL, Google Scholar, EMBASE, the Register of Controlled Trials, and Ovid MEDLINE from January 2017 to August 2023 using one or a combination of the following terms: \"netarsudil,\" \"rhopressa,\" \"Rho-kinase,\" \"pediatric glaucoma,\" \"childhood glaucoma,\" \"intraocular pressure\" was conducted.</p><p><strong>Results: </strong>Eight publications (four retrospective studies, one prospective study, and three case reports) were identified evaluating the outcomes of topical netarsudil in childhood glaucoma. Six publications were conducted in the United States, and two publications were conducted in India. Studies included a heterogeneous cohort of primary and secondary childhood glaucoma with a variable range of follow-up (1 week-26 months). The mean IOP reduction after the initiation of topical netarsudil 0.02% in childhood glaucoma patients varies from 0.8 ± 13.2 to 12.0 ± 0.0 mmHg. The most common ocular adverse event was conjunctival hyperemia, seen in 27 out of 82 eyes (32.9%), followed by corneal honeycombing/reticular epithelial edema, seen in 13 out of 82 eyes (15.9%).</p><p><strong>Conclusion: </strong>Limited literature is currently available on using topical netarsudil in childhood glaucoma. However, in children with refractory glaucoma on maximum topical medications, netarsudil may serve as an adjunctive treatment option, potentially delaying the need for further surgical interventions in some patients. Careful corneal examination is needed before and after initiation of netarsudil treatment for early detection of corneal adverse events that may compromise the vision.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"461-466"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrating Retinal Segmentation Metrics with Machine Learning for Predictions from Mouse SD-OCT Scans.","authors":"Maide Gözde İnam, Onur İnam, Xiangjun Yang, Qun Zeng, Gülgün Tezel","doi":"10.1080/02713683.2025.2456783","DOIUrl":"10.1080/02713683.2025.2456783","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to initially test whether machine learning approaches could categorically predict two simple biological features, mouse age and mouse species, using the retinal segmentation metrics.</p><p><strong>Methods: </strong>The retinal layer thickness data obtained from C57BL/6 and DBA/2J mice were processed for machine learning after segmenting mouse retinal SD-OCT scans. Twenty-two models were trained to predict the mouse groups. The best neural network model was optimized for better outcomes. Prediction accuracy, the area under the curve, sensitivity, specificity, precision, and F-1 score values were obtained.</p><p><strong>Results: </strong>The Wilcoxon Signed-Rank test provided significantly higher validation accuracy for neural networks than decision trees, discriminant analysis, support vector machines, and k-nearest neighbor classifiers (<i>p</i> = 0.005 for all). For C57BL/6-DBA/2J classification, a mean validation accuracy of 88.11 ± 3.92% (95% CI: 86.99-89.22) was achieved for the neural network when the optimized neural network had 92.31% final test accuracy with an area under the curve value of 0.9762, 94.44% sensitivity, 90.48% specificity, 89.47% precision, and 0.92 F-1 score. The optimized neural network model for age group differentiation had a final test accuracy of 82.05% with a 0.9064 area under the curve value, 77.27% sensitivity, 88.24% specificity, 89.47% precision, and 0.83 F-1 score.</p><p><strong>Conclusions: </strong>These findings validate that machine learning, using segmentation metrics instead of images, can effectively analyze retinal OCT scans in mice for categorical predictions in experimental models. Expanding this approach with additional features, including histopathological and functional correlations, is expected to improve the prediction power further, promising valuable applications to predict more complex outcomes in experimental and clinical studies.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"502-511"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12037304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship of Angle Kappa with Ocular Parameters using Swept-Source Ocular Coherence Tomography in Cataract Surgery Patients.","authors":"Mayank A Nanavaty, Margarita Safir, Laura McLaughlin, Joy White","doi":"10.1080/02713683.2025.2452915","DOIUrl":"10.1080/02713683.2025.2452915","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the relationship between angle kappa (apparent chord mu) and ocular parameters in cataract patients.</p><p><strong>Methods: </strong>In this cross-sectional study, the data on apparent chord mu, age, axial length, anterior chamber depth, anterior and posterior mean keratometry, mean total keratometry, white-to-white, central corneal thickness and lens thickness were collected for consecutive cataract patients. Correlation (Pearson) between chord mu and the other ocular parameters was calculated. A stepwise backward multiple regression analysis was performed to identify the combination of ocular parameters strongly correlating to chord mu.</p><p><strong>Results: </strong>Two thousand four hundred and sixty-four eyes (1232 patients) were included in this study. The mean age was 72.7 ± 12.7 years (18-97 years). Univariate analysis showed a significant positive correlation of chord mu to age (<i>R</i> = 0.06, <i>p</i> = .01), lens thickness (<i>R</i> = 0.12, <i>p</i> < .01), mean keratometry (<i>R</i> = 0.08, <i>p</i> < .01), and mean total keratometry (<i>R</i> = 0.08, <i>p</i> < .01). Whereas there was a significant negative correlation with white-to-white (<i>R</i> = -0.04, <i>p</i> = .03), axial length (<i>R</i> = -0.19, <i>p</i> < .01), and anterior chamber depth (<i>R</i> = -0.2, <i>p</i> < .01). Male gender (<i>R</i> = -0.04, <i>p</i> = .05) and central corneal thickness (<i>R</i> = 0.04, <i>p</i> = .06) were not significantly correlated. Multivariate stepwise backward regression analysis showed a combination of four factors (female sex, reduced axial length and anterior chamber depth and steep mean keratometry) significantly related to chord mu (angle kappa).</p><p><strong>Conclusion: </strong>Female gender, reduced axial length and anterior chamber depth, and higher mean keratometry correlate to apparent chord mu (angle kappa) in cataract patients. These findings can help identify vulnerable patients who can have appropriate counseling on the prognosis of postoperative optical and visual outcomes.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"496-501"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142982918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cohesin Complex Interacting with Promoters of MMP Genes for in Pterygium Occurrence.","authors":"Shichao Han, Wei Zhu, Qianqian Guo","doi":"10.1080/02713683.2025.2452919","DOIUrl":"10.1080/02713683.2025.2452919","url":null,"abstract":"<p><strong>Purpose: </strong>Pterygium is a common ocular surface disease characterized by a high recurrence rate and unknown etiology.</p><p><strong>Methods: </strong>In this study, we investigated the upregulation of matrix metalloproteinase genes, including MMP1, MMP2, MMP3, MMP7, MMP9, MMP11, MMP12, MMP13, MMP23B, and MMP28, in pterygium tissue using RNA sequencing, Western blotting, and immunohistochemistry.</p><p><strong>Results: </strong>Employing the MEME tool, we identified a conserved DNA motif within the promoter regions of these matrix metalloproteinase genes. Mass spectrometry analysis revealed an interaction between the cohesin complex and this motif. Disrupting the cohesin complex through RNA interference of RAD21 cohesin complex component or structural maintenance of chromosomes 3 in primary pterygial fibroblasts led to decreased matrix metalloproteinase gene expression and reduced recruitment of twist family bHLH transcription factor 1 and transcription factor 4 to matrix metalloproteinase gene promoters.</p><p><strong>Conclusion: </strong>Overall, our findings suggest a novel epigenetic mechanism regulating matrix metalloproteinase transcription in pterygium.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"467-476"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Performance of Topical Insulin in Persistent Corneal Epithelial Defects and Persistent Corneal Ulcers - A Case Series.","authors":"Amalia Mester, Maximilian Gabriel, Ingrid Boldin, Haleh Aminfar, Nora Woltsche, Astrid Heidinger, Andreas Guttmann, Paul Wintersteller, Jutta Horwath-Winter","doi":"10.1080/02713683.2025.2456784","DOIUrl":"10.1080/02713683.2025.2456784","url":null,"abstract":"<p><strong>Purpose: </strong>To retrospectively describe the performance of topical insulin in persistent corneal epithelial defects (CED) and persistent corneal ulcers.</p><p><strong>Methods: </strong>We reviewed cases of patients treated for persistent CED and persistent corneal ulcers using topical insulin in a concentration of 25 IU per milliliter three times per day. The closure rate of CED and corneal ulcers was the main outcome measure.</p><p><strong>Results: </strong>Thirty-seven episodes of 29 patients treated with topical insulin were reviewed. There was a wide range of additionally used medication, underlying pathologies as well as ocular and systemic comorbidities in our cohort. On average, insulin drops were started after 36 days of conventional therapy (SD 59, range 0-193) and were used for 42 days (SD 38, range 3-130). Therapy success was achieved in 15 of 28 (53.5%) cases with CED and in 4 of 9 (44%) cases with corneal ulcers. While insulin generally showed a good safety profile, one patient reported intolerable discomfort related to the use of topical insulin.</p><p><strong>Conclusion: </strong>Topical insulin may be considered as a treatment option in complicated cases refractory to conventional treatment, but outcomes may be less favorable than previously reported.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"477-480"},"PeriodicalIF":1.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}