Current Eye Research最新文献

{"title":"Visual Function and Patient Experience with a Custom-Made Soft Contact Lens for Myopia Control.","authors":"Youssef Abidi, A Eusebio López-Hernández, José Manuel Maldonado-Pérez, José Miguel Sánchez-Ruiz, Johnny Di Pierdomenico, Diego García-Ayuso","doi":"10.1080/02713683.2025.2524842","DOIUrl":"10.1080/02713683.2025.2524842","url":null,"abstract":"<p><strong>Purpose: </strong>The aim was to evaluate the impact of a custom-made soft contact lens (CL) for myopia control on visual function and wearer experience.</p><p><strong>Methods: </strong>In this masked, randomized study, 23 myopic adults (aged 18-35) were fitted with ESENCIA CLs made of either Acofilcon B (hydrogel) or UNISIL (silicone hydrogel). Visual and accommodative function, tear stability, and wearer experience were assessed.</p><p><strong>Results: </strong>Visual acuity remained stable with both CLs. No significant differences were found between the two CLs in any test. However, both CLs increased monocular and binocular accommodative facility (MAF and BAF) compared to baseline (Acofilcon B: <i>p</i> < 0.001 for MAF, <i>p</i> = 0.008 for BAF; Unisil: <i>p</i> < 0.001 for MAF, <i>p</i> = 0.011 for BAF). Increased exophoria was noted at distance and near with both lenses (Acofilcon B: <i>p</i> = 0.004, <i>p</i> = 0.002; Unisil: <i>p</i> = 0.006, <i>p</i> = 0.001), and a reduction in negative fusional reserves at distance was observed (Acofilcon B: <i>p</i> = 0.008; Unisil: <i>p</i> = 0.01). Other tests showed results similar to baseline. Subjective scores indicated a trend toward better comfort and satisfaction with Unisil (7.29 ± 2.03) compared to Acofilcon B (6.48 ± 2.00).</p><p><strong>Conclusion: </strong>Our results highlight the importance of evaluating the potential side effects on visual quality and binocular and accommodative functions when selecting CLs for myopia control. Additionally, considering the user's subjective experience is crucial, as CLs must be worn for a minimum number of hours each day.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1072-1083"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144607742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic Far-UVC (222nm) Light Exposure of SKH-1 Hairless Mice Does Not Cause Detectable Eye Pathology or Visual Deficits.","authors":"Peter C Arden, Maria J Talayero Schettino, Matthew D Ramey, David Welch, Nabil A Mahmoud, Imke T Folkerts, David J Brenner, Norman J Kleiman","doi":"10.1080/02713683.2025.2524564","DOIUrl":"10.1080/02713683.2025.2524564","url":null,"abstract":"<p><strong>Purpose: </strong>Far-UVC light (200-235 nm) is a new antimicrobial technology proposed for use in occupied spaces. In contrast to conventional germicidal UV light (254 nm), theoretical considerations and emerging safety data suggest that the decreased penetration depth of shorter wavelength far-UVC light causes less damage to vulnerable eye and skin tissue. This study examined the ocular effects of chronic far-UVC exposure in hairless, immune-competent SKH-1 mice after long-term exposure.</p><p><strong>Methods: </strong>Over 66 weeks, five days/week, eight hours/day, 48 each male and female mice were exposed to high (400 mJ/cm²), medium (130 mJ/cm²), low (55 mJ/cm²), or no (0 mJ/cm²) far-UVC (222 nm) light. Visual acuity and contrast sensitivity was determined using optokinetic methods, slit lamp examinations were made of the anterior segment, and intraocular pressure was determined. Analysis of corneal images quantified the extent of corneal neovascularization.</p><p><strong>Results: </strong>No significant differences in visual acuity, contrast sensitivity, intraocular pressure, or corneal neovascularization were observed between unirradiated animals and exposure groups. All groups, including unexposed controls, exhibited some degree of corneal neovascularization. Male mice had significantly lower visual acuity and contrast sensitivity than females. Stratified by gender, there was no exposure condition-based difference in contrast sensitivity. These findings were consistent whether each animal's eyes were averaged. or if all eyes were assessed individually.</p><p><strong>Conclusion: </strong>There was no relationship between far-UVC dose and visual acuity, contrast sensitivity, ocular pressure, or corneal neovascularization. Female mice had significantly higher visual acuity and contrast sensitivity. No ocular pathologies were observed, even at 400 mJ/cm², substantially above the recently enacted ACGIH safety threshold of 160 mJ/cm² for 222 nm ocular exposures. More sensitive or detailed corneal examinations, longer daily exposures, or higher far-UVC doses, may be useful to define thresholds for human eye safety.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1064-1071"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774864","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Bacillus Coagulans</i> Secretes Extracellular Vesicles and Modulates the Proliferation of Conjunctival Epithelial Cells via the P53/CDKN1A Signaling Pathway.","authors":"Jingyu Zhang, Ruiming Yang, Jiamian Liang, Qiudan Huang, Amy Michelle Huang, Wangjian Qiu, Fang Li, Li Wang, Yue Liang, Zhiping Liu","doi":"10.1080/02713683.2025.2513556","DOIUrl":"10.1080/02713683.2025.2513556","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the microbial strains in pterygium patients' tear samples <i>via</i> 16S rRNA sequencing and evaluate their impact on human conjunctival epithelial cells (HConEpics) and pterygium fibroblasts (HPFs) proliferation.</p><p><strong>Methods: </strong>Tear samples were cultured aerobically and anaerobically on blood agar plates. Bacterial colonies were characterized by 16S rRNA sequencing. Proliferation of HConEpics and HPFs was assessed using CCK-8 and EDU assays. The role of bacterial extracellular vesicles (EVs) was explored using the exosome inhibitor GW4869. EVs were isolated and characterized by transmission electron microscopy and nanoparticle tracking analysis (NTA), with DIL staining confirming their internalization by host cells. Transcriptomic sequencing and the SIRT2-IN-11 inhibitor were used to elucidate the molecular mechanisms and regulatory pathways.</p><p><strong>Results: </strong>16S rRNA analysis revealed a significant reduction in the concentration of <i>Bacillus coagulans</i> (BC) in pterygium patients. BC significantly promoted HConEpics proliferation while inhibiting HPFs proliferation. GW4869 significantly reduced the stimulatory effect of BC culture supernatant on HConEpics proliferation, confirming EVs-medicated regulation. BC-derived EVs, isolated by ultracentrifugation, were internalized by HConEpics, promoting proliferation and inducing G1 phase cell cycle accumulation. These EVs also inhibited TGF-β-induced damage to HConEpics. Transcriptomic sequencing identified the p53 pathway as a key regulatory pathway, further clarified by SIRT2-IN-11.</p><p><strong>Conclusions: </strong>This study offers novel insights into pterygium pathogenesis and identifies potential therapeutic targets.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"982-993"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144257515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synergistic Suppression of Choroidal Neovascularization by Cavtratin and Aflibercept via Inhibition of the eNOS Pathway.","authors":"Yue Dong, Yanlin Li, Xuan Zhou, Wei Huang, Shasha Yang, Huishan Lin, Kun Wei, Jingwei Yao, Haoyu Zuo, Chengguo Zuo","doi":"10.1080/02713683.2025.2523916","DOIUrl":"10.1080/02713683.2025.2523916","url":null,"abstract":"<p><strong>Purpose: </strong>Choroidal neovascularization (CNV) is a key pathological feature of exudative age-related macular degeneration (AMD), leading to severe vision loss. Despite anti-vascular endothelial growth factor (anti-VEGF) therapies being the first-line treatment for neovascularization, their long-term application faces challenges including treatment insensitivity and drug resistance. This study aims to investigate the role of Caveolin-1 (Cav-1) in CNV pathogenesis and evaluate the therapeutic potential of Cavtratin, a Cav-1 scaffolding domain-targeting peptide, alone and in combination with Aflibercept.</p><p><strong>Methods: </strong>A laser-induced CNV model in aged mice and VEGF-stimulated human umbilical vein endothelial cells (HUVECs) were used to assess Cav-1 expression dynamics and its interaction with endothelial nitric oxide synthase (eNOS). The effects of Cavtratin on angiogenesis were evaluated using tube formation assays, choroidal sprouting assays, and fluorescein angiography. Western blot and immunofluorescence staining were employed to analyze changes in molecular expression, localization, and inflammatory responses. The efficacy of Cavtratin-Aflibercept combination therapy was examined.</p><p><strong>Results: </strong>Cav-1 and eNOS were significantly upregulated during CNV progression (<i>p</i> < 0.001). Cavtratin effectively inhibited tube formation in HUVECs, suppressed choroidal sprouting <i>ex vivo</i>, and reduced CNV leakage <i>in vivo</i> (<i>p</i> < 0.01). Mechanistically, Cavtratin suppressed eNOS phosphorylation and enhanced the anti-angiogenic effects of Aflibercept (<i>p</i> < 0.001). The combination therapy led to greater CNV inhibition, reduced inflammation, and allowed for a lower Aflibercept dosage while maintaining therapeutic efficacy.</p><p><strong>Conclusion: </strong>Cavtratin combined with Aflibercept can effectively enhance anti-angiogenic efficacy and reduce inflammatory responses. Targeting the Cav-1/eNOS axis with Cavtratin provides a novel strategy to complement the limitations of anti-VEGF therapy. The synergistic effects of Cavtratin and Aflibercept suggest a promising approach to overcoming treatment resistance and improving clinical outcomes in CNV management.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1054-1063"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Vascular Changes in Acne Patients Under Isotretinoin Treatment: An Optical Coherence Tomography Angiography Study.","authors":"Serhat Eker, Gülcan Saylam Kurtipek, Yalcin Karakucuk, Fatma Tuncez Akyurek, Mustafa Tugrul Ugur, Cahit Yavuz","doi":"10.1080/02713683.2025.2565787","DOIUrl":"https://doi.org/10.1080/02713683.2025.2565787","url":null,"abstract":"<p><strong>Purpose: </strong>This study was designed to assess retinal and choroidal microvasculature in acne patients using oral isotretinoin with optical coherence tomography angiography.</p><p><strong>Materials and methods: </strong>One hundred and one eyes of 101 patients diagnosed with acne using isotretinoin and 105 eyes of 105 healthy subjects underwent retinal and choroidal assessment with the Triton swept-source deep range imaging optical coherence tomography device (Topcon Corp., Tokyo, Japan). The patients' superficial (VDs), deep (VDd), and choriocapillar (VDc) vascular densities were examined. Foveal avascular zones in the superficial (FAZs) and deep (FAZd) layers, as well as the central macular thickness (CMT) and subfoveal choroidal thickness (SFCT), were measured.</p><p><strong>Results: </strong>In total, 32 males and 69 females were assessed. The mean duration of isotretinoin use was 81 days (range: 30-210 days). The cumulative dose of medication used was 2334 mg (range: 600-7200 mg). VDs and VDd showed no differences between the acne patients and the controls (<i>p</i> > 0.05). All sectors of the VDc values were significantly higher in the patients compared to the controls (<i>p</i> < 0.05). FAZs and FAZd were significantly higher in the patients compared to the controls (<i>p</i> = 0.048 and <i>p</i> = 0.041, respectively). The mean CMT significantly decreased in the patient group compared to the control group (<i>p</i> = 0.001), while the mean SFCT significantly increased (<i>p</i> = 0.002). The VDc superior values of the patients who used isotretinoin for more than 3 months were significantly higher than those of the patients who used the drug for less than 3 months (<i>p</i> = 0.01). We did not find any correlation with the total dose of isotretinoin, except for the nasal sector value of VDc (<i>r</i> = -0.199, <i>p</i> = 0.046).</p><p><strong>Conclusions: </strong>Alterations of macular microvasculature were observed in acne patients using isotretinoin. In particular, a significant increment in choriocapillaris blood flow was detected.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal Association of Decreased Serum Uric Acid Level with the Thinning of Ganglion Cell Inner Plexiform Layer Thickness in Chinese Adults with Type 2 Diabetes Mellitus without Retinopathy.","authors":"Yiran Fan, Yuntong Li, Lingyi Li, Xinyan Wu, Yayi Yan, Ching-Kit Tsui, Kaiqun Liu, Wenyong Huang, Xiaoling Liang, Andina Hu","doi":"10.1080/02713683.2025.2517301","DOIUrl":"10.1080/02713683.2025.2517301","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the associations between serum uric acid (SUA) level change and changes in the retinal neurodegenerative biomarkers in type 2 diabetes mellitus patients without retinopathy.</p><p><strong>Methods: </strong>This is a prospective observational cohort study based on the baseline and 1-year follow-up data of the Guangzhou Diabetic Eye Study. Type 2 diabetes mellitus patients without retinopathy were recruited. Thicknesses of ganglion cell inner plexiform layer (GC-IPL) and peripapillary retinal nerve fiber layer (pRNFL) were measured via swept-source optical coherence tomography. The associations between SUA level change and the thinning rates of GC-IPL and pRNFL were analyzed using multivariate linear regression analysis. Sub-group analysis based on sex was constructed.</p><p><strong>Results: </strong>A total of 1084 participants were enrolled in our study. After adjustment, both male and female patients with decreased SUA levels in higher baseline SUA level group had a significantly slower thinning rate of GC-IPL than those with non-decreased SUA levels. In higher baseline SUA level with decreased SUA level group, male patients exhibited significantly slower thinning rate of inferior GC-IPL, while female patients exhibited significantly slower thinning rate of inferior and nasal GC-IPL and inferior pRNFL, when compared to those with non-decreased SUA levels.</p><p><strong>Conclusion: </strong>Our findings prove that decreased SUA level is associated with a slower GC-IPL thinning rate in higher baseline SUA level group, suggesting that decreased SUA level could be constituted as a potential future control target to delay the neurodegeneration in type 2 diabetes mellitus patients.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1045-1053"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fenofibrate Exerts Protective Effects in Diabetic Retinopathy.","authors":"Shimei Chen, Xiaoqian Wang, Dandan Sun, Shuchang Zhang, Peiyu Liu, Xun Xu, Fang Wei, Qing Liu","doi":"10.1080/02713683.2025.2516802","DOIUrl":"10.1080/02713683.2025.2516802","url":null,"abstract":"<p><strong>Purpose: </strong>This study examines the protective effects of fenofibrate on retinal health in diabetic retinopathy, focusing on its ability to reduce inflammation, oxidative stress, and restore autophagy while preventing ferroptosis.</p><p><strong>Methods: </strong>Using a streptozotocin (STZ)-induced diabetic rat model and cultured ARPE-19 cells under high glucose conditions, we assessed the impact of fenofibrate on oxidative stress markers, autophagy-related proteins, and tight junction integrity. Fenofibrate's role in modulating inflammation and preventing ferroptosis was also evaluated.</p><p><strong>Results: </strong>Fenofibrate treatment reduced ROS production and NADPH oxidase activity, alleviating oxidative stress in retinal tissues. Additionally, fenofibrate enhanced autophagy, as indicated by increased LC3 expression, and maintained tight junction protein expression. These effects contributed to the stabilization of cellular homeostasis, potentially slowing disease progression.</p><p><strong>Conclusion: </strong>Fenofibrate offers significant protective effects in diabetic retinopathy by reducing inflammation and oxidative stress, promoting autophagy, and inhibiting ferroptosis, making it a promising therapeutic option for managing the disease.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1010-1018"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retinal Microglia: Revealing New Opportunities for Identifying Early Biomarkers of Diabetic Retinopathy.","authors":"Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita","doi":"10.1080/02713683.2025.2517300","DOIUrl":"10.1080/02713683.2025.2517300","url":null,"abstract":"<p><strong>Purpose: </strong>To explore the role of microglia in the pathomechanism of diabetic retinopathy (DR) from an inflammatory perspective.<b>Methods:</b> The study was conducted by searching several databases. Relevant articles were collected, summarized, and concluded.</p><p><strong>Results: </strong>Numerous studies have been conducted to identify inflammatory biomarkers for effective detection of DR; however, the results have been inconsistent. Microglia, the resident immune cells of the retinal tissue, are believed to play a potential role in the neuroinflammatory process induced by prolonged hyperglycemia in the retina. The excessive release of extracellular adenosine triphosphate (eATP) due to hyperglycemia may overstimulate P2X7R receptors, thereby activating the NLRP3 inflammasome, and leading to chronic progressive inflammation.</p><p><strong>Conclusion: </strong>Microglial activation and polarization may induce meta-inflammation, contributing to increased permeability and neovascularization, which in turn lead to proliferative diabetic retinopathy. Understanding this mechanism is essential for identifying potential biomarkers for early DR detection and developing adjunctive therapies to control disease progression.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"973-981"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Tobramycin-Dexamethasone Combination Eyedrop Versus Artificial Tear Eyedrop for the Management of Presumed Viral Epidemic Conjunctivitis: A Randomized Treatment Trial.","authors":"Chintan Shah, Courtney F Goodman, Alok Sen, Deepak P Edward, Manish Tijare","doi":"10.1080/02713683.2025.2515997","DOIUrl":"10.1080/02713683.2025.2515997","url":null,"abstract":"<p><strong>Purpose: </strong>To compare the efficacy and safety of one-time povidone-iodine (PovI) administration followed by a course of tobramycin-dexamethasone eye drops versus artificial tears in acute viral conjunctivitis (AVC).</p><p><strong>Methods: </strong>This was a single-centre, randomized controlled trial. Patients with AVC were instilled with PovI (5%) after proparacaine and then divided into two groups using a computer-generated random number table. Group A received combination drops of tobramycin(0.3%) and dexamethasone(0.5%), and group B received carboxymethylcellulose(0.5%) eyedrops. Both groups administered one drop four times daily for at least three days and until complete symptom resolution. A symptom score (SS) encompassing the five symptoms (redness, lid swelling, foreign body sensation, pain, watering; max score 15) was calculated at baseline, day 3, and day 7.</p><p><strong>Results: </strong>The study included 230 eyes (120 in group A, 110 in group B). There was a significant reduction in mean total SS at day 3 (2.16 ± 2.42) and day 7 (0.56 ± 1.14) in all eyes compared to at presentation (8.33 ± 2.46). At day 3, there was a lower mean total SS in group A (1.97 ± 2.31) compared to group B (2.36 ± 2.54) which was marginally significant (<i>p</i> = 0.086). At day 7, the proportion of eyes that were symptom-free was similar between groups (70.9%, <i>p</i> = 0.881). A multivariate analysis found that group B (OR = 2.08, <i>p</i> = 0.036) and a higher pain score (OR = 1.50, <i>p</i> = 0.046) were associated with a lack of clinical resolution by day 3.</p><p><strong>Conclusion: </strong>A course of tobramycin-dexamethasone combination eyedrops after PovI may lead to early symptomatic relief, but recovery was similar to artificial tears by day 7. No significant/sight-threatening complications were observed in any groups.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"994-1002"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144368644","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantification of Conjunctival Dendritiform Cells under <i>In Vivo</i> Confocal Microscopy for Clinical Activity Evaluation in Thyroid Eye Disease.","authors":"Jianhao Cai, Tiancheng Zheng, Tsz Kin Ng, Cangeng Xu, Zifeng Zhao, Zeyi Li","doi":"10.1080/02713683.2025.2521865","DOIUrl":"10.1080/02713683.2025.2521865","url":null,"abstract":"<p><strong>Purpose: </strong>To quantify the conjunctival dendritiform cells of patients with thyroid eye disease by <i>in vivo</i> confocal microscopy and to investigate its correlation with thyroid eye disease clinical activity.</p><p><strong>Methods: </strong>In total, 60 thyroid eye disease patients with 60 eyes were recruited and divided into active and inactive groups based on their clinical activity scores. The dendritiform cells at the conjunctiva were examined by <i>in vivo</i> confocal microscopy. The correlation of the conjunctival dendritiform cell density with the clinical activity scores of the thyroid eye disease patients was analyzed. The receiver operating characteristics curve was used to assess the differentiation of active and inactive thyroid eye disease by the dendritiform cells.</p><p><strong>Results: </strong>The densities of dendritiform cells in the nasal, temporal, and total conjunctiva of the patients with active thyroid eye disease were significantly higher than that of the patients with inactive thyroid eye disease (<i>p</i> < .001). There was no significant difference in dendritiform cell density between the nasal and temporal conjunctiva of the same patient (<i>p</i> = .122). Total conjunctival dendritiform cell density showed a significant positive correlation with the clinical activity scores (<i>r</i> = 0.519, <i>p</i> < .001). The area under the receiver operating characteristics curve for total conjunctival dendritiform cells to differentiate active and inactive thyroid eye disease was 0.827 with a sensitivity of 77.80% and specificity of 78.80%.</p><p><strong>Conclusion: </strong>Quantification of conjunctival dendritiform cells by the <i>in vivo</i> confocal microscopy can help to assess the clinical activity of thyroid eye disease. The <i>in vivo</i> confocal microscopy can visualize the conjunctival lesions at the cellular level and possess potential clinical applications in thyroid eye disease.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1003-1009"},"PeriodicalIF":2.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144483444","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}