Current Eye Research最新文献

{"title":"Effects of <i>Laurus Nobilis</i> Eye Drop on Selenite-Induced Cataract Formation and Oxidative Stress-Related Parameters in Rabbits: An Experimental Study.","authors":"Marisa Palazzo, Marina Concilio, Luigi Ambrosone, Michele Rinaldi, Fausto Tranfa, Ciro Costagliola","doi":"10.1080/02713683.2024.2380440","DOIUrl":"10.1080/02713683.2024.2380440","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the protective role of <i>Laurus Nobilis</i> eye drops on selenite-induced cataracts in suckling rabbits.</p><p><strong>Methods: </strong>Fifteen male albino suckling rabbits with no signs of ocular inflammation were randomly assigned to three groups: controls (Group A), sodium-selenite group (Group B) and sodium-selenite plus <i>Laurus Nobilis</i> group (Group C). By selenite treatment, cataract formation was experimentally induced and then graded. The grade of oxidative stress was defined in the lens, measuring the concentration of malondialdehyde, alpha-tocopherol, oxidized glutathione, ascorbic acid and hydrogen peroxide, and in blood samples as levels of alpha-tocopherol and malondialdehyde.</p><p><strong>Results: </strong>Mean lens concentrations of GSSG, H2O2, and MDA levels in group B were significantly higher than in both group C and control. Ascorbic acid and alpha-tocopherol concentrations were lower in group B than in both group C and A. As plasma oxidative status markers, the level of MDA was higher in group B respected group C and A. The mean alpha-tocopherol levels in group B were significantly lower than in both group A and group C.</p><p><strong>Conclusions: </strong>In animals treated with <i>Laurus Nobilis</i>-based eye drops, inflammation was inhibited, and lipid peroxidation was significantly reduced. <i>Laurus nobilis</i> leaves extract represents a good source of antioxidant components that may contrast sodium selenite-induced cataractogenesis in suckling rabbits.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1247-1252"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Ripasudil Hydrochloride on Epithelial Repair in a Mouse Cornea.","authors":"Yukihisa Takada, Shingo Yasuda, Takayoshi Sumioka, Yuka Okada, Tadahiko Tamura, Osamu Yamanaka, Shizuya Saika","doi":"10.1080/02713683.2024.2378018","DOIUrl":"10.1080/02713683.2024.2378018","url":null,"abstract":"<p><strong>Purpose: </strong>Effect of topical administration of a Rho kinase inhibitor, ripasudil, on epithelial wound healing in a mouse cornea was investigated. Effects of treatment of cultured human corneal epithelial cell (HCEC) line and organ-cultured corneal epithelium with ripasudil on expression of p-ERK was also examined.</p><p><strong>Methods: </strong>Epithelial defects with a diameter of 2.0 mm were prepared in the central corneas of C57BL/6 mice with or without 1-week travoprost pre-treatment, to which ripasudil or PBS as a control was instilled every 6 h immediately after preparation. The mice eyes were cultured with or without travoprost for 24-hrs. The expression levels of p-ERK in epithelium of mice eyes were compared by immunostaining after further 24-hrs culture with or without ripasudil for 24-hrs. HCEC were cultured with or without ripasudil and processed for examination for proliferation activity and protein expression of p-ERK by either immunostaining or Western blotting. The cells were also treated with or without travoprost for 24-hrs, and were further cultured with or without ripasudil. Expression levels of p-ERK were examined by Western blotting.</p><p><strong>Results: </strong>Ripasudil treatment suppressed post-debridement epithelial healing in association with reduced proliferation activity in peripheral (limbal) epithelium in cornea with or without pre-treatment with travoprost. Ripasudil treatment accelerated p-ERK expression. Ripasudil supplementation upregulated proliferation with increased p-ERK in HCEC.</p><p><strong>Conclusion: </strong>Ripasudil treatment promotes wound healing of the mouse corneal epithelium by enhancing cell proliferation on peripheral (limbal) epithelium.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1215-1222"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"List of Reviewers for Volume 49.","authors":"","doi":"10.1080/02713683.2024.2428045","DOIUrl":"https://doi.org/10.1080/02713683.2024.2428045","url":null,"abstract":"","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":"49 12","pages":"I-III"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Dual-Modal Fusion Network Using Optical Coherence Tomography and Fundus Images in Detection of Glaucomatous Optic Neuropathy.","authors":"Yongli Xu, Run Sun, Man Hu, Hui Zeng","doi":"10.1080/02713683.2024.2375401","DOIUrl":"10.1080/02713683.2024.2375401","url":null,"abstract":"<p><strong>Purpose: </strong>We designed a dual-modal fusion network to detect glaucomatous optic neuropathy, which utilized both retinal nerve fiber layer thickness from optical coherence tomography reports and fundus images.</p><p><strong>Methods: </strong>A total of 327 healthy subjects (410 eyes) and 87 glaucomatous optic neuropathy patients (113 eyes) were included. The retinal nerve fiber layer thickness from optical coherence tomography reports and fundus images were used as predictors in the dual-modal fusion network to diagnose glaucoma. The area under the receiver operation characteristic curve, accuracy, sensitivity, and specificity were measured to compare our method and other approaches.</p><p><strong>Results: </strong>The accuracy of our dual-modal fusion network using both retinal nerve fiber layer thickness from optical coherence tomography reports and fundus images was 0.935 and we achieved a significant larger area under the receiver operation characteristic curve of our method with 0.968 (95% confidence interval, 0.937-0.999). For only using retinal nerve fiber layer thickness, we compared the area under the receiver operation characteristic curves between our network and other three approaches: 0.916 (95% confidence interval, 0.855, 0.977) with our optical coherence tomography Net; 0.841 (95% confidence interval, 0.749, 0.933) with Clock sectors division; 0.862 (95% confidence interval, 0.757, 0.968) with inferior, superior, nasal temporal sectors division and 0.886 (95% confidence interval, 0.815, 0.957) with optic disc sectors division. For only using fundus images, we compared the area under the receiver operation characteristic curves between our network and other two approaches: 0.867 (95% confidence interval: 0.781-0.952) with our Image Net; 0.774 (95% confidence interval: 0.670, 0.878) with ResNet50; 0.747 (95% confidence interval: 0.628, 0.866) with VGG16.</p><p><strong>Conclusion: </strong>Our dual-modal fusion network utilizing both retinal nerve fiber layer thickness from optical coherence tomography reports and fundus images can diagnose glaucoma with a much better performance than the current approaches based on optical coherence tomography only or fundus images only.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1253-1259"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Influence of Accommodative Demand on Ocular Aberrations: A Study of Zernike Coefficients Repeatability and Variability.","authors":"María Mechó-García, María Arcas-Carbonell, Elvira Orduna-Hospital, Ana Sánchez-Cano, José Manuel González-Méijome","doi":"10.1080/02713683.2024.2378009","DOIUrl":"10.1080/02713683.2024.2378009","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the repeatability of the Zernike coefficients in healthy eyes when monocular accommodation was stimulated at different vergences demands.</p><p><strong>Methods: </strong>A total of 36 right eyes from healthy volunteers were prospectively and consecutively recruited for this study. Wavefront aberrometry was conducted to objectively characterize the ocular optical quality during accommodation, from the individual's far point to a 5 D accommodation demand in steps of 0.5 D. The repeatability of Zernike coefficients up to the fourth order was assessed by calculating the within-eye repeatability (<i>Sw</i>), the coefficient of repeatability (<i>CR</i>), the coefficient of variation (<i>CV</i>), and the intraclass correlation coefficient (<i>ICC</i>) as an indicator of measurement reliability.</p><p><strong>Results: </strong>Correlation among repeated measurements showed high reliability (ICC > 0.513) for all parameters measured except some fourth-order Zernike coefficients, C(4, -4) (ICC < 0.766), C(4, -2) (ICC < 0.875), C(4, 2) (ICC < 0.778) and C(4, 4) (ICC < 0.811). Greater repeatability and less variability were obtained for high-order Zernike coefficients (CR < 0.154), although an increase in CR in the coefficients analyzed was observed with increasing accommodative demand. No clear trend was evident in CV; however, it was observed that the low-order Zernike coefficients exhibit lower CV (CV < 1.93) compared to the high-order Zernike coefficients (CV > 0).</p><p><strong>Conclusions: </strong>The reliability of Zernike coefficients up to the fourth order in healthy young individuals demonstrated a strong consistency in measuring terms up to the fourth order, with more variability observed for high-order terms. The Zernike coefficients up to the third order exhibited the highest level of repeatability.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1237-1246"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141616057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Efficacy of the Diluted Schirmer Method for Tear Collection in Dry Eye Syndrome Patients.","authors":"Li Yang, Xiuming Jin, Shengjia Hu, Pingping Yu, Xinchang Wang","doi":"10.1080/02713683.2024.2380446","DOIUrl":"10.1080/02713683.2024.2380446","url":null,"abstract":"<p><strong>Purpose: </strong>This study assesses the diluted Schirmer method's effectiveness in collecting tears from dry eye syndrome patients, aiming to identify the most suitable tear collection technique for them.</p><p><strong>Methods: </strong>A prospective study. Tear samples were collected from patients with dry eye syndrome and healthy individuals using two methods: (1) Direct Schirmer Method: Schirmer strips were directly inserted into the eye to collect tears. (2) Diluted Schirmer Method: After instilling physiological saline into the eye and waiting for 30 s to ensure thorough mixing with tears, Schirmer strips were used for collection. Tear samples from both groups were analyzed and compared for total protein and cytokine levels (IL-1β, IL-6, IL-8, TNF-α).</p><p><strong>Results: </strong>(1) The study included 32 participants: 16 with dry eye syndrome (4 males, 12 females, average age 34.92 ± 10.13 years) and 16 healthy controls (5 males, 11 females, average age 32.25 ± 9.87 years). (2) The diluted Schirmer method produced a significantly larger tear volume compared to the direct method (<i>p</i> < 0.05), with lower Visual Analogue Scale (VAS) scores indicating less discomfort (<i>p</i> < 0.05). (3) The average total protein content of the two groups was 51.70 ± 3.166 ng measured by Direct Schirmer method, and the average total protein content of the Diluted Schirmer method was 50.05 ± 3.263 ng. There was no statistical difference between the two groups. (<i>t</i> = 1.051, <i>p</i> = 0.3098) (4) The concentrations of total tear protein and various cytokines measured by both methods were higher in the dry eye group compared to the normal group, with statistically significant differences (<i>p</i> < 0.05). Both methods reflected consistent changes in tear protein profiles.</p><p><strong>Conclusion: </strong>The diluted Schirmer method can comfortably collect an adequate volume of tear samples in a short time and consistently reflect changes in tear proteins, making it an effective method for tear collection in patients with dry eye syndrome.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1223-1230"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141747627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Melatonin Improves Oxidative Stress Injury in Retinopathy of Prematurity by Targeting miR-23a-3p/Nrf2.","authors":"Zhi-Xian Gou, Yue Zhou, Yang Fan, Feng Zhang, Xue-Mei Ning, Fei Tang, Li-Qun Lu","doi":"10.1080/02713683.2024.2380433","DOIUrl":"10.1080/02713683.2024.2380433","url":null,"abstract":"<p><strong>Purpose: </strong>Melatonin has promising protective effects for retinopathy. However, its roles in retinopathy of prematurity (ROP) and the underlying mechanisms remain unknown. We aimed to explore its roles and mechanisms in a ROP model.</p><p><strong>Methods: </strong>Hematoxylin and eosin staining were used to observe the morphology of the retina. Immunofluorescence was used to detect positive (Nrf2+ and VEGF+) cells. Immunohistochemistry was used to detect the level of nuclear expression of PCNA in retinal tissue. Transmission electron microscope (TEM) was used to observe the morphology and structure of pigment cells. qRT-PCR was used to assay the expression of miR-23a-3p, Nrf2, and HO-1. Western blotting was used to detect the expression of Nrf2, HO-1, β-actin, and Lamin B1.</p><p><strong>Results: </strong>Melatonin or miR-23a-3p antagomir treatment could ameliorate the Oxygen-induced pathological changes, increased the expression of Nrf2 and HO-1, SOD, and GSH-Px, and decreased the expression of VEGF, miR-23a-3p, MDA and the apoptosis in the ROP model. Further target prediction and luciferase reporter assays confirmed the targeted binding relationship between miR-23a-3p and Nrf2.</p><p><strong>Conclusion: </strong>Our study showed that melatonin could ameliorate H₂O₂-induced apoptosis and oxidative stress injury in RGC cells by mediating miR-23a-3p/Nrf2 signaling pathway, thereby improving retinal degeneration.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1295-1307"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the Ocular Hypertension Model in Mice Induced by Dexamethasone-21-Acetate - Implications for Glaucoma Research.","authors":"Maximilian Binter, Miriam Heider, Silke Glage, Heiko Fuchs, Fridolin Langer, Thomas Schigiel, Carsten Framme, Jan Tode","doi":"10.1080/02713683.2024.2380445","DOIUrl":"10.1080/02713683.2024.2380445","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to assess the effectiveness of monocular and bilateral injections of Dexamethasone-21-acetate (Dex-21-Ac) into the murine fornix twice a week as a glucocorticoid-induced ocular hypertension model and investigated potential systemic side effects.</p><p><strong>Methods: </strong>Dex-21-Ac was administered twice weekly in three groups: bilateral injections, monocular injections, and a control group receiving the vehicle solution bilateral. After 21 days, enucleated eyes were examined using immunocytochemistry (ICC), and organ histology was performed.</p><p><strong>Results: </strong>All groups receiving Dex-21-Ac injections had a significant increase in intraocular pressure (IOP). Monocular injections also resulted in a significant increase in IOP in the fellow eye. The Dex-21-Ac-treated groups showed a bilateral increase in IOP of approximately 8 mmHg, accompanied by elevated expression of alpha smooth muscle actin and fibronectin in the anterior chamber angle. There were no significant changes in weight progression. Hepatic steatosis was observed in all Dex-21-Ac-treated animals, and some suffered from residual neuromuscular blockade under fentanyl anesthesia.</p><p><strong>Conclusion: </strong>Bilateral injections of Dex-21-Ac twice a week lead to a significant increase in daytime IOP and fibrotic changes in the trabecular meshwork. Unilateral application has a significant impact on the fellow eye. Local dexamethasone leads to notable systemic effects independent of changes in animal weight. Considering liver damage and associated influence on metabolization, hepatically eliminated injection anesthetics may lead to overdosing and are not recommended. They should be replaced by inhalation anesthesia.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1269-1277"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Macular Pigment Optical Density (MPOD) Decrease in Chinese Primary Angle Closure Glaucoma Using the One-Wavelength Reflectometry Method.","authors":"Zhihong Huang, Yuying Ji, Dingqiao Wang, Ni Guo, Ling Jin, Shaoyang Zheng, Yuan Liu, Huanyang Shi, Mingkai Lin, Chengguo Zuo","doi":"10.1080/02713683.2024.2381864","DOIUrl":"10.1080/02713683.2024.2381864","url":null,"abstract":"<p><strong>Purpose: </strong>The objective of this study was to observe the macular pigment optical density (MPOD) and the relationship between MPOD and retinal thickness in Chinese primary angle-closure glaucoma (PACG) patients by the one-wavelength reflectometry method.</p><p><strong>Methods: </strong>This study was a prospective comparative observational study, including 39 eyes from 39 PACG patients (15 men and 24 women, mean age 61.89 ± 12.30) and 41 eyes from 41 controls (20 men and 21 women, mean age 63.24 ± 14.02). We measured the MPOD 7-degree area by the one-wavelength reflectometry method and analyzed both the max and mean optical density (OD). The central retinal thickness (CRT) and the total thickness of the macular ganglion cell layer (GCL), and inner plexiform layer (IPL)were measured by spectral-domain-optical coherence tomography (SD-OCT). Statistical methods such as Shapiro-Wilk test, Fisher's exact test, chi-square test, two independent samples test and Spearman's correlation coefficient were used to observe the differences in the MPOD between normal subjects and PACG patients and the correlation between the MPOD and retinal thickness.</p><p><strong>Results: </strong>The max optical density (Max OD) (PACG group: 0.302 ± 0.067d.u, control group: 0.372 ± 0.059d.u., <i>p</i> < .001) and mean optical density (Mean OD) (PACG group: 0.124 ± 0.035d.u., control group: 0.141 ± 0.028d.u., <i>p</i> < 0.05) were significantly reduced in PACG patients compared with control subjects. Significant decreases in GCL + IPL thickness (PACG group: 74.71 ± 39.56 μm, control group:113.61 ± 8.14 μm, <i>p</i> < 0.001) and CRT (PACG group: 254.49 ± 41.47 μm, control group:329.10 ± 18.57 μm, <i>p</i> < 0.001) were also observed in PACG eyes. There was no statistically significant correlation between the MPOD and GCL + IPL thickness (<i>p</i> = .639, <i>p</i> = .828).</p><p><strong>Conclusions: </strong>MPOD was significantly lower in Chinese PACG patients than in the control group, potentially due to thinning of the GCL + IPL thickness. This study provides insights for the pathophysiology, assessment of PACG and potential guidance for lifestyle modifications.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1260-1268"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141893106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous-Fibrin Induction: A Novel Approach for Sutureless Sclerotomy Closure in Pars Plana Vitrectomy.","authors":"Ebubekir Durmus, Ahmad Kunbaz, Sabire Pelin Kaya, Fehim Esen, Halit Oguz, Veysel Aykut","doi":"10.1080/02713683.2024.2380441","DOIUrl":"10.1080/02713683.2024.2380441","url":null,"abstract":"<p><strong>Purpose: </strong>This study presents a novel sutureless closure approach for sclerotomies following pars plana vitrectomy (PPV) and assesses its efficacy and safety.</p><p><strong>Methods: </strong>A total of 142 eyes were included in the study. PPV procedures were performed using 23-gauge (23 G) or 25-gauge (25 G) systems. Preoperative characteristics, intraoperative findings, and postoperative outcomes were documented.</p><p><strong>Results: </strong>The cohort included 80 males and 62 females (mean age: 60.4 ± 12 years), primarily undergoing surgery for retinal detachment (59%). Among the patients, 87% underwent 25 G PPV (35% three-port, 52% four-port), while 13% underwent 23 G PPV (12% three-port, 1% four-port). Gas tamponade was administered in all cases, with perfluoropropane used in 45.7% of instances, sulfur hexafluoride in 29.5%, and air in 24.6%. Spontaneous closure was observed in 9.4% (47 of 501) of sclerotomies, autologous-fibrin induction approach successfully closed 75.8% (380 of 501) of the sclerotomies (83.7% of leaking sclerotomies) and 14.7% (74 of 501) of sclerotomies needed sutures. Visual acuity improved postoperatively, and first-day hypotony rate was 6.3%. Importantly, no serious complications such as choroidal detachment or endophthalmitis were observed during the postoperative period.</p><p><strong>Conclusion: </strong>The autologous-fibrin induction offers a simple, cost-efficient, and reliable approach for sutureless sclerotomy closure in PPV, with promising outcomes.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1308-1312"},"PeriodicalIF":1.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141626255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}