The Role of Small Extracellular Vesicles in Retinoblastoma Development and Progression.

IF 1.7 4区 医学 Q3 OPHTHALMOLOGY
Jyothi Attem, Geeta K Vemuganti
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引用次数: 0

Abstract

A growing body of research on extracellular vesicles (EVs) in cancer has revealed their novel and crucial activities in the progression of tumors while also paving the way for potential therapeutic interventions. It is now known that EVs are natural delivery vehicles for particular payloads of source cells, enabling them to influence diverse functions of cells both in healthy and malignant cells. In this review, we comprehensively summarize mechanistic insights into sEV roles in RB, the most frequent intraocular malignancy that affects the retina of young children. We also explore the therapeutic potential of sEVs as an emerging area as biomarkers and vehicles for targeted therapy. Additionally, we address the potential challenges and limitations of translating sEVs-based technologies into clinical practice.

细胞外小泡在视网膜母细胞瘤发育和发展中的作用
越来越多的关于细胞外囊泡(EVs)在癌症中的研究揭示了它们在肿瘤进展中的新颖和关键的活动,同时也为潜在的治疗干预铺平了道路。现在已知,ev是特定源细胞有效载荷的天然递送载体,使其能够影响健康和恶性细胞中细胞的多种功能。在这篇综述中,我们全面总结了sEV在RB中的作用机制,RB是影响幼儿视网膜的最常见的眼内恶性肿瘤。我们还探索了sev作为生物标志物和靶向治疗载体的新兴领域的治疗潜力。此外,我们解决了将基于sev的技术转化为临床实践的潜在挑战和限制。
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来源期刊
Current Eye Research
Current Eye Research 医学-眼科学
CiteScore
4.60
自引率
0.00%
发文量
163
审稿时长
12 months
期刊介绍: The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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