Current Eye Research最新文献

{"title":"Outcomes of Powered Revision Endoscopic DCR and Utility of Three-Dimensional Computed Tomography Dacryocystography (3D CT-DCG).","authors":"Ayushi Agarwal, Sumer Doctor, E Ravindra Mohan, Mohammad Javed Ali, Nandini Bothra","doi":"10.1080/02713683.2025.2487067","DOIUrl":"10.1080/02713683.2025.2487067","url":null,"abstract":"<p><strong>Purpose: </strong>To analyze the causes of failure in primary external dacryocystorhinostomy versus endoscopic dacryocystorhinostomy and surgical outcomes of powered revision endoscopic dacryocystorhinostomy and the role of pre-operative lacrimal imaging in surgical planning.</p><p><strong>Methods: </strong>Retrospective, interventional study on patients with an earlier failed dacryocystorhinostomy who underwent revision endoscopic dacryocystorhinostomy surgery from January 2016 to June 2024. Data collected included the demographic profile, clinical presentation, details of prior intervention, pre- and intra-operative endoscopic findings, adjunctive procedures, and the computed tomography dacryocystography characteristics. Successful outcomes were anatomic success (patent irrigation) and functional success (resolution of epiphora).</p><p><strong>Results: </strong>Two hundred and ten lacrimal drainage systems of 205 patients who underwent revision endoscopic dacryocystorhinostomy were analyzed. The mean age at the presentation was 45 years. Of the 210 lacrimal surgeries, 17 (8%) had multiple surgeries, 129 (61%) underwent prior endoscopic dacryocystorhinostomy, and 81 (39%) had external dacryocystorhinostomy. One hundred and eight (51%) primary surgeries were performed by an ophthalmologist, 94 (45%) by an ear nose throat surgeon, and eight (3.8%) were unknown. The most common cause of failure was complete cicatricial closure (73%) followed by interfering osteo-septal synechiae (20%). The most common location of previous osteotomy was inferior (37%). Preoperative three-dimensional computed tomography-dacryocystography showed inadequate superior osteotomy in 62.5%, and sac displacement in 57%. Three-dimensional computed tomography-dacryocystography correlated with intra-operative findings in 96% cases. Adjunct procedures were performed in 42% of revision endoscopic dacryocystorhinostomy's. Successful outcome was achieved in 199 (94.7%), regardless of nature of primary surgery (<i>p</i> = .63), at 3-months follow-up.</p><p><strong>Conclusion: </strong>With proper planning, comparable success to external approach can be achieved with a revision endoscopic dacryocystorhinostomy. Computed tomography dacryocystography in select cases can guide surgical planning and anticipate intra-operative challenges.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"752-757"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143779364","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Outcomes of Pterygium Extended Removal Combined with Conjunctival Autograft and Amniotic Membrane Transplantation.","authors":"Kuanshu Li, Kehua Wang, Guihua Zou, Congxiang Wang, Wei Huang","doi":"10.1080/02713683.2025.2488022","DOIUrl":"10.1080/02713683.2025.2488022","url":null,"abstract":"<p><strong>Purpose: </strong>To observe the Long-term results of pterygium extended removal combined conjunctival autograft and amniotic membrane transplantation.</p><p><strong>Methods: </strong>This is a prospective study of 666 eyes (606 patients, 332 right eyes and 336 left eyes). All patients underwent pterygium extended removal combined conjunctival autograft and amniotic membrane transplantation in a same hospital. The primary outcome measures included the cosmetic appearances and recurrence rate; the secondary outcome measures were some serious complications, like Keratitis, conjunctival cyst and conjunctival granuloma.</p><p><strong>Results: </strong>606 patients (82.34% of surviving) were able to be followed up. The mean follow-up period was 29.96 ± 13.34 months. Recurrence was noted in 7 eyes (1.05%), and there were no serious complications. 89.04% of eyes were graded as having excellent cosmetic appearance.</p><p><strong>Conclusions: </strong>The long-term recurrence rate of pterygium extended removal combined conjunctival autograft and amniotic membrane Graft is very low, and the long-term cosmetic appearance is excellent. And also, there were no other serious complications.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"695-699"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Femtosecond Laser Liquid Optics Interface as Low Vision Optical Resource.","authors":"Norton Sakassegawa Yanagimori, Bernardo Kaplan Moscovici, Gicele Rodrigues Chaves Rinaldo, Priscila Ciocler Froiman, Ivan Corso Teixeira","doi":"10.1080/02713683.2025.2478239","DOIUrl":"10.1080/02713683.2025.2478239","url":null,"abstract":"<p><strong>Purpose: </strong>To assess the efficacy of a low-cost optical magnifier created from the repurposed femtosecond laser interface used in cataract surgery to reduce healthcare waste and financial burden for low-vision patients.</p><p><strong>Methods: </strong>This prospective study included 16 Brazilian patients from the Low Vision Department of the Irmandade da Santa Casa de Misericórdia de São Paulo. Participants had visual acuity between +0.5 and +1.3 logMAR and visual field constrictions under 20°. The Catalys^® femtosecond laser interface lens, usually discarded after surgery, was sterilized and attached to a recyclable support to create a magnifying device. Patients were trained to use it for 30 days. Visual function was assessed with the NEI VFQ-25, and reading performance was measured using the MNREAD-P test.</p><p><strong>Results: </strong>Thirteen patients (81.25%) completed the study. The use of the optical device led to significant improvements in all MNREAD-P parameters. Reading acuity improved from 0.74 ± 0.19 logMAR (20/110 Snellen) to 0.41 ± 0.22 logMAR (20/50 Snellen) (<i>p</i> < 0.001). Critical print size decreased from 0.85 ± 0.19 logMAR (20/140 Snellen) to 0.56 ± 0.24 logMAR (20/70 Snellen) (<i>p</i> < 0.001). Maximum reading speed increased from 41.4 ± 18.0 words per minute (wpm) to 56.2 ± 25.2 wpm (<i>p</i> < 0.001). NEI VFQ-25 scores improved from 32.7 ± 13.8 to 46.9 ± 15.0 (<i>p</i> < 0.001), with increases observed in all subcategories, particularly in \"Reactions to Vision Problems.\"</p><p><strong>Conclusion: </strong>Repurposing the femtosecond laser interface lens as a low-cost magnifier showed promising improvements in reading and visual function for low-vision patients while addressing healthcare waste. Further studies with larger samples are recommended to validate and expand this sustainable approach in visual rehabilitation.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"719-724"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>In Vivo</i> Dose-Response Effect of 300 nm UV Radiation on the Ocular Lens Epithelial Cells Count.","authors":"Zhaohua Yu","doi":"10.1080/02713683.2025.2490771","DOIUrl":"10.1080/02713683.2025.2490771","url":null,"abstract":"<p><strong>Purpose: </strong>To assess how varying doses of ultraviolet radiation affect the distribution of lens epithelial cells.</p><p><strong>Methods: </strong>Forty Sprague Dawley rats were exposed unilaterally to ultraviolet radiation-300 nm at doses of 1, 3, 6, and 8 kJ/m². One week after exposure, lenses from both the exposed and the unexposed contralateral eyes were collected for analysis. A midsagittal section from each lens was stained with 4',6-diamidino-2-phenylindole and examined using fluorescence microscopy to evaluate lens epithelial cell distribution.</p><p><strong>Results: </strong>The difference in lens epithelial cell density between exposed and non-exposed eyes at doses of 1, 3, 6, and 8 kJ/m² was measured as 95% confidence interval values of -0.1 ± 2.1, 0.1 ± 3.0, -4.1 ± 1.4, and -2.9 ± 2.7 cell·μm^-1·10^-2, respectively. Data were analyzed using a linear model with the initial density difference set to zero. The slope of the dose-response relationship was estimated as 95% confidence interval -0.4 ± 0.1 cell·μm·kJ^-1·10¹⁰.</p><p><strong>Conclusion: </strong>Exposure to ultraviolet radiation-300 nm reduces lens epithelial cell density. The linear model provides a quantitative understanding of the relationship between ultraviolet radiation dose and cell density.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"730-735"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143982713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Telemedicine Postoperative Protocol Following Microincision Vitrectomy Surgery (MIVS).","authors":"Heun Min, Noraliz Garcia-O'Farrill, Patricia Garcia, Andrew Thomson, Allan A Hunter","doi":"10.1080/02713683.2025.2490768","DOIUrl":"10.1080/02713683.2025.2490768","url":null,"abstract":"<p><strong>Purpose: </strong>Retrospective studies show a low proportion of postoperative (PO) complications or alterations in management after Microincision Vitrectomy Surgery (MIVS). To our knowledge, this is the first prospective analysis of a telemedicine alternative to the standard practice for PO visits after MIVS. The purpose of this study is to evaluate telemedicine for the management of postoperative visits (POV) following MIVS.</p><p><strong>Methods: </strong>Ongoing randomized, prospective study with 53 patients assigned (1:1) to two arms of POV schedules including Virtual Telemedicine visits (VT) <i>vs.</i> In-person Telemedicine (IP) visits. POV schedules in both groups included visits on the same day after surgery and week(s) 1, 2, 8, and 12. Complete exams with visual acuity, intraocular pressure, and dilated fundus exams of the operative eye were performed by the retina surgeon on day 0, weeks 2 and 12 in both groups. Protocolized focused undilated exams on weeks 1 and 8 either remotely (VT group) or in-person (IP group). Statistical analyses included Mann-Whitney U tests between groups using Microsoft Excel.</p><p><strong>Results: </strong>Primary outcome, mean POV logMAR BCVA, showed no statistically significant difference (<i>p</i>-value = 0.70) between VT and IP groups. Other pre- and post-surgical comparisons (e.g. IOP, RNFL score) showed no statistical differences. No post-surgical complications have been noted.</p><p><strong>Conclusions: </strong>Telemedicine-assisted POV may be a safe and convenient alternative for patients undergoing uncomplicated MIVS, but additional and larger studies are needed.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"745-751"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlations of Thioredoxin and Thioredoxin Interacting Protein with Type 2 Diabetes Mellitus Complicated with Diabetic Retinopathy.","authors":"Jiasu Liu, Xuebin Yu, Maryam Chudhary, Hui Qi, Na Zhang, Shiwen Zhong, Qi Zhao, Xiang Ren, Hui Kong, Li Kong","doi":"10.1080/02713683.2025.2487069","DOIUrl":"10.1080/02713683.2025.2487069","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the relationship between Thioredoxin (Trx), Thioredoxin interacting protein (Txnip), and the severity of diabetic retinopathy (DR).</p><p><strong>Methods: </strong>The study involved a total of 101 eyes, comprising of 31 healthy controls, 24 diabetic patients with no clinically detectable retinopathy (NDR group), 26 patients with non-proliferative DR (NPDR group), and 20 patients with proliferative DR (PDR group), including 62 males and 49 females, average aged 61.65 ± 9.4. Retinal morphology was evaluated using spectral domain optical coherence tomography (SD-OCT), while retinal function was assessed using full-field electroretinogram (ffERG) to record the amplitudes and implicit time. The correlation between serum Trx, Txnip, and DR was analyzed using Spearman correlation analysis.</p><p><strong>Results: </strong>In the early stage of DR, there was no significant difference in macular retinal thickness between groups; in the PDR group, there was a significant increase compared to both the NDR and control groups, particularly in the central fovea (<i>p</i> < 0.0001). Additionally, the amplitude and implicit time of oscillatory potentials exhibited a significant difference between the NDR and control groups at an early stage of DR (<i>p</i> < 0.001). Furthermore, the amplitude of rod and cone ERG decreased significantly in the early stage of DR, while the implicit time began to decline in the NPDR stage. The serum levels of Trx and Txnip exhibited a positive correlation with the progression of DR (<i>r</i> = 0.851, 0.762). Conversely, a negative correlation was observed between the serum levels of Trx and Txnip and the amplitudes of ERG, while a positive correlation was observed with the implicit time of ERG.</p><p><strong>Conclusions: </strong>The serum levels of Trx and Txnip exhibit a positive correlation with retinopathy associated with type 2 diabetes mellitus (T2DM), and thus may be utilized as a potential target for the timely diagnosis and treatment of DR.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"736-744"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Waveform Score Influences the Outcome Metrics of the Ocular Response Analyzer in Patients with Keratoconus and in Healthy Controls.","authors":"Phillip T Yuhas, Maddison M Fortman, Michael Nye, Ashraf M Mahmoud, Cynthia J Roberts","doi":"10.1080/02713683.2025.2489607","DOIUrl":"10.1080/02713683.2025.2489607","url":null,"abstract":"<p><strong>Purpose: </strong>To test whether the intraocular-pressure (IOP) and biomechanical outcome metrics from the Ocular Response Analyzer (ORA) differ between the measurement with the highest waveform score and the average of four measurements of any waveform score in participants with keratoconus and in controls.</p><p><strong>Methods: </strong>Patients with diagnosed keratoconus and healthy controls were recruited prospectively. Four measurements were made using a third-generation ORA. Goldmann-correlated IOP (IOPg), corneal-compensated IOP (IOPcc), corneal hysteresis (CH), corneal resistance factor (CRF), waveform score, and six waveform parameters (p1area, p2area, w1, w2, h1, and h2) were considered as outcome metrics. In the left eye, outcomes from the measurement with the highest waveform score were compared against averaged outcomes from four measurements of any waveform score using either paired t-tests or Wilcoxon signed-rank tests. Receiver operating characteristic (ROC) curves tested ability of both data-selection approaches to differentiate the cohorts.</p><p><strong>Results: </strong>One-hundred ninety-two (<i>N</i> = 192) participants were enrolled. In the control cohort (<i>n</i> = 145), waveform score, CH, p2area, and h2 were all significantly greater for the best-waveform-score measurement than for the average-waveform-score measurement. IOPcc and w2 were significantly less for the best-waveform-score measurement than for the average-waveform-score measurement. In the keratoconus cohort (<i>n</i> = 47), waveform score, p1area, p2area, h1, and h2 were all significantly greater for the best-waveform-score measurement than for the average-waveform-score measurement. W2 was significantly less for the best-waveform-score measurement than for the average-waveform-score measurement. The area under the ROC curve was high for both data-selection approaches.</p><p><strong>Conclusion: </strong>In general, the best measurement had higher and narrower waveform peaks than the averaged measurement, which suggests better alignment between the device and the eye in the former than in the latter. Thus, making multiple measurements and then analyzing the one with the single highest quality may be preferred to analyzing the average of the group.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"700-709"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187544/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PM2.5 Stimulates Macrophage-Derived Thymic Stromal Lymphopoietin (TSLP) to Induce a Mouse Model of Allergic Conjunctivitis.","authors":"Yazhou Qin, Yue Bian, Jingbo Hu, Yuyao Qu, Ruoying Liu, Jixian Ma, Jingming Li, Bo Ma, Cheng Pei, Ning Gao","doi":"10.1080/02713683.2025.2487066","DOIUrl":"10.1080/02713683.2025.2487066","url":null,"abstract":"<p><strong>Purpose: </strong>Increasing epidemiologic evidence has indicated that PM2.5 exposure is strongly correlated with the prevalence of allergic conjunctivitis (AC), but there is no experimental model for elucidating the underlying mechanism involved. We established a stable PM2.5-induced mouse model of AC to explore the adverse effects of PM2.5 on the ocular surfaces and the underlying mechanisms involved.</p><p><strong>Methods: </strong>BALB/c mice were sensitized by intraplanar injection of 200 μg PM2.5 on day 0 and challenged for 10 consecutive days, beginning on day 9, with eye drops containing 12.5 mg/mL PM2.5. Assessments of the ocular surfaces, eye blink counts, and tear secretion were performed to evaluate clinical symptoms. The whole eyes were harvested for histopathological and immunofluorescence analyses, the conjunctiva was isolated for Western blotting, and the sera were subjected to IgE ELISA to evaluate the immune characteristics and TSLP-related pathway expression. Furthermore, mouse bone marrow-derived macrophages (BMDMs) were incubated with 25 μg/mL PM2.5 for 24 h. Cellular protein and RNA were extracted for Western blotting and RNA sequencing.</p><p><strong>Results: </strong>PM2.5 exposure induced clinical manifestations and pathological changes similar to those in human AC. The sensitization and challenge evoked Th2 responses and serum IgE production. PM2.5 exposure mediated TSLP production in macrophages and aggravated allergic inflammation through the TSLP-TSLPR and TSLP-OX40L signaling pathways <i>in vivo</i>. Macrophages produced TSLP and polarized to the M1 phenotype after PM2.5 administration <i>in vitro</i>.</p><p><strong>Conclusions: </strong>These results demonstrate a reproducible method for establishing a PM2.5-induced AC model. In addition, PM2.5 exposure stimulated macrophages to secrete TSLP and enhance allergic inflammation.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"684-694"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is Selective Laser Trabeculoplasty Effective in Reducing Intraocular Pressure for Primary Angle-Closure Glaucoma? A Systematic Review and Meta-Analysis.","authors":"Kai-Yang Chen, Hoi-Chun Chan, Chi-Ming Chan","doi":"10.1080/02713683.2025.2481306","DOIUrl":"10.1080/02713683.2025.2481306","url":null,"abstract":"<p><strong>Purpose: </strong>Primary angle-closure glaucoma (PACG) is a significant cause of blindness globally, particularly in Asian populations, where it accounts for 25% of glaucoma cases. Selective laser trabeculoplasty (SLT) has emerged as a promising treatment for PACG, but its efficacy varies across studies. This meta-analysis aims to evaluate the effectiveness of SLT in reducing intraocular pressure (IOP) and compare outcomes between PACG and primary open-angle glaucoma (POAG).</p><p><strong>Methods: </strong>A systematic search was conducted in PubMed, Scopus, Medline, and EMBASE up to July 2024 using predefined criteria. Studies assessing SLT in patients with PACG were included. Data extraction included study characteristics, SLT parameters, and primary outcomes, such as mean post-intervention IOP reduction and SLT failure rates. Statistical analysis was performed using pooled estimates with 95% confidence intervals (CI) through Comprehensive Meta-Analysis software.</p><p><strong>Results: </strong>Of the 754 potentially relevant articles assessed, 7 met the inclusion criteria. The mean IOP post-SLT among PACG patients significantly decreased to 17.30 mmHg (95% CI: 16.99-17.61; <i>p</i> = 0.0001). The SLT failure rate in PACG was 7.95% (95% CI: 6.15-10.28%; <i>p</i> = 0.00001). Studies reported varying trends in medication use and the need for further interventions post-SLT in PACG patients.</p><p><strong>Conclusions: </strong>This study comprehensively examined the effectiveness of SLT in treating PACG across multiple studies. Despite variations in sample sizes, demographics, and study locations, SLT effectively reduced IOP in PACG patients. The meta-analysis demonstrated a statistically significant decrease in mean post-SLT IOP, highlighting its therapeutic benefit despite notable heterogeneity among the included studies.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"657-667"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143763268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, Production and Study of Flexible Acrylic Keratoprosthesis.","authors":"Victoria H Fan, Michael G Sun, Ahmed F Al-Qahtani, Ibraim V Vieira, Charles Q Yu","doi":"10.1080/02713683.2025.2485186","DOIUrl":"10.1080/02713683.2025.2485186","url":null,"abstract":"<p><strong>Purpose: </strong>To design, produce and implant one-piece flexible acrylic keratoprostheses for the treatment of corneal blindness.</p><p><strong>Methods: </strong>A protocol was developed to produce flexible acrylic sheets of differing properties, and their mechanical characteristics were evaluated. To assess <i>in vitro</i> toxicity, an MTT assay was performed. 3D-printed injection molding technique of this material was designed to fabricate flexible keratoprostheses with complex shapes. A pilot study involving a 3-month implantation in a rabbit was conducted, including histological analysis.</p><p><strong>Results: </strong>Flexible acrylic copolymer sheets of high clarity were produced by free radical polymerization. Their mechanical properties and refractive indices could be altered with different material formulations. They demonstrated no <i>in vitro</i> toxicity in human corneal cells <i>via</i> MTT assay. 3D printed silver molds allowed for the production of keratoprostheses of complex shapes made from these materials. Surgical implantation resulted in clear implant at 3 months.</p><p><strong>Conclusions: </strong>Molding of flexible acrylic allows for production of one-piece keratoprostheses of a complex shape and opens new possibilities for the treatment of corneal blindness.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"677-683"},"PeriodicalIF":1.7,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}