Jiasu Liu, Xuebin Yu, Maryam Chudhary, Hui Qi, Na Zhang, Shiwen Zhong, Qi Zhao, Xiang Ren, Hui Kong, Li Kong
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引用次数: 0
Abstract
Purpose: To investigate the relationship between Thioredoxin (Trx), Thioredoxin interacting protein (Txnip), and the severity of diabetic retinopathy (DR).
Methods: The study involved a total of 101 eyes, comprising of 31 healthy controls, 24 diabetic patients with no clinically detectable retinopathy (NDR group), 26 patients with non-proliferative DR (NPDR group), and 20 patients with proliferative DR (PDR group), including 62 males and 49 females, average aged 61.65 ± 9.4. Retinal morphology was evaluated using spectral domain optical coherence tomography (SD-OCT), while retinal function was assessed using full-field electroretinogram (ffERG) to record the amplitudes and implicit time. The correlation between serum Trx, Txnip, and DR was analyzed using Spearman correlation analysis.
Results: In the early stage of DR, there was no significant difference in macular retinal thickness between groups; in the PDR group, there was a significant increase compared to both the NDR and control groups, particularly in the central fovea (p < 0.0001). Additionally, the amplitude and implicit time of oscillatory potentials exhibited a significant difference between the NDR and control groups at an early stage of DR (p < 0.001). Furthermore, the amplitude of rod and cone ERG decreased significantly in the early stage of DR, while the implicit time began to decline in the NPDR stage. The serum levels of Trx and Txnip exhibited a positive correlation with the progression of DR (r = 0.851, 0.762). Conversely, a negative correlation was observed between the serum levels of Trx and Txnip and the amplitudes of ERG, while a positive correlation was observed with the implicit time of ERG.
Conclusions: The serum levels of Trx and Txnip exhibit a positive correlation with retinopathy associated with type 2 diabetes mellitus (T2DM), and thus may be utilized as a potential target for the timely diagnosis and treatment of DR.
目的：探讨硫氧还蛋白（Trx）、硫氧还蛋白相互作用蛋白（Txnip）与糖尿病视网膜病变（DR）严重程度的关系。方法：研究共101只眼，其中健康对照31例，无临床可检出视网膜病变的糖尿病患者24例（NDR组），非增生性DR 26例（NPDR组），增生性DR 20例（PDR组），其中男性62例，女性49例，平均年龄61.65±9.4岁。使用光谱域光学相干断层扫描（SD-OCT）评估视网膜形态，使用全场视网膜电图（ffERG）评估视网膜功能，记录振幅和隐式时间。采用Spearman相关分析血清Trx、Txnip与DR的相关性。结果：DR早期，两组患者黄斑视网膜厚度差异无统计学意义；在PDR组中，与NDR组和对照组相比，PDR组有显著增加，特别是在中央凹（p p r = 0.851, 0.762）。相反，血清Trx和Txnip水平与ERG振幅呈负相关，而与ERG隐式时间呈正相关。结论：血清Trx和Txnip水平与2型糖尿病（T2DM）视网膜病变呈正相关，可作为及时诊断和治疗DR的潜在靶点。
期刊介绍：
The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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