Effect of Meibomian Gland Expression on Optical Quality in Patients with Meibomian Gland Dysfunction.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

Current Eye Research Pub Date : 2025-04-28 DOI:10.1080/02713683.2025.2497324

Hongzhe Li, Wentao Tong, Man Hu, Ziqi Meng, Pingjun Chang, Yune Zhao

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引用次数: 0

Abstract

Purpose: To evaluate the changes in meibomian gland function, ocular surface parameters, and optical quality before and after meibomian gland expression in patients with meibomian gland dysfunction (MGD).

Methods: Patients with MGD underwent meibomian gland expression once weekly for 4 consecutive weeks. Comprehensive assessments, including the Ocular Surface Disease Index questionnaire, tear break-up time, corneal fluorescein staining, lid margin abnormality grading, meibum expressibility and quality evaluations, Schirmer I test (SIT), as well as optical quality examinations using the Pentacam and Optical Quality Analysis System II, were conducted before and after the treatment.

Results: 124 eyes of 62 patients were included in the study. Most meibomian gland function and ocular surface parameters showed significant improvement after treatment. Except for and coma (p = .029), no other significant changes in optical quality were observed. Changes in SIT were significantly correlated with changes in total corneal high-order aberrations (tHOA-4mm) (r = -.224, p = .019). Changes in objective scattering index were significantly associated with changes in spherical aberration (r = .219, p = .022), trefoil (r = .797, p < .001), total high-order aberrations (r = .408, p < .001) and total corneal spherical aberration (r = .590, p < .001).

Conclusion: Meibomian gland expression effectively improves meibomian gland function and ocular surface parameters. However, it does not appear to significantly impact optical quality in patients with MGD.

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睑板腺表达对睑板腺功能障碍患者光学质量的影响。

目的：评价睑板腺功能障碍（MGD）患者睑板腺表达前后睑板腺功能、眼表参数及光学质量的变化。方法：MGD患者每周一次进行睑板腺表达，连续4周。治疗前后进行眼表疾病指数问卷、泪液破裂时间、角膜荧光素染色、眼睑边缘异常分级、细胞表达性和质量评价、Schirmer I试验（SIT）以及Pentacam和光学质量分析系统II光学质量检查等综合评估。结果：62例患者124只眼纳入研究。治疗后睑板腺功能及眼表参数均有明显改善。除了和昏迷（p = 0.029）外，未观察到其他明显的光学质量变化。SIT的变化与角膜总高阶像差（tHOA-4mm）的变化显著相关（r = -）。224, p = 0.019)。物镜散射指数的变化与球像差的变化显著相关(r =。219, p = 0.022)，三叶草（r = 0.022）。797, p r =。408, p r =。结论：睑板腺表达可有效改善睑板腺功能和眼表参数。然而，它似乎对MGD患者的光学质量没有显著影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Eye Research 医学-眼科学

CiteScore

4.60

自引率

0.00%

发文量

163

审稿时长

12 months

期刊介绍： The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.