Current Eye Research最新文献_第2页

Microsecond Pulsing Laser for Choroidal Neovascularization Associated with Central Serous Chorioretinopathy. 微秒脉冲激光治疗与中央浆液性脉络膜视网膜病变相关的脉络膜新生血管。

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-03-01 Epub Date: 2024-10-23 DOI: 10.1080/02713683.2024.2419667

Dmitrii S Maltsev, Alexei N Kulikov, Alexander S Vasiliev, Alina A Kazak, Yana A Kalinicheva, Jay Chhablani

{"title":"Microsecond Pulsing Laser for Choroidal Neovascularization Associated with Central Serous Chorioretinopathy.","authors":"Dmitrii S Maltsev, Alexei N Kulikov, Alexander S Vasiliev, Alina A Kazak, Yana A Kalinicheva, Jay Chhablani","doi":"10.1080/02713683.2024.2419667","DOIUrl":"10.1080/02713683.2024.2419667","url":null,"abstract":"Purpose: To analyze the efficacy and safety of microsecond pulsing laser therapy (MLT) in the management of central serous chorioretinopathy (CSCR) complicated by choroidal neovascularization (CNV).Methods: Patients with CSCR complicated by CNV defined as the presence of characteristic OCT angiography features were randomly assigned to either study or control group. All patients of the study group underwent MLT targeting CNV area using navigated laser system followed by at least 6-month follow-up. Sham treatment was performed in the control group. No other treatment or anti-VEGF therapy was used during the follow-up. Main outcome measure was complete resolution of subretinal fluid at the end of follow-up.Results: Twenty-three eyes (13 males and 10 females, mean age 58.2 ± 8.0 years) with a mean CNV area 0.62 ± 0.77 mm2 were included in the study group. Fourteen (60.9%) patients achieved complete resolution of SRF, five (21.7%) patients demonstrated some reduction of SRF, and four (17.4%) patients demonstrated no improvement after MLT in the study group. Twelve eyes (8 males and 4 females, mean age 59.8 ± 4.6 years) were included in the control group where none of them demonstrated resolution of SRF at the end of the follow-up (p = 0.0018 compared to the study group). No adverse effects, such as changes of CNV size, deterioration of exudation, or decline in visual acuity were observed in the study group.Conclusion: Microsecond pulsing laser is an effective and safe option for the treatment of CSCR complicated by relatively small CNV and achieves complete resolution of SRF in 61% of cases.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"304-313"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Visual Acuity and Refractive Status in Congenital Macular Coloboma. 先天性黄斑部色素瘤的视力和屈光状态。

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-03-01 Epub Date: 2024-11-04 DOI: 10.1080/02713683.2024.2424266

Pingxiao Yang, Yilin Chen, Wentao Li, Ting Yang, Lijun Huo

{"title":"Visual Acuity and Refractive Status in Congenital Macular Coloboma.","authors":"Pingxiao Yang, Yilin Chen, Wentao Li, Ting Yang, Lijun Huo","doi":"10.1080/02713683.2024.2424266","DOIUrl":"10.1080/02713683.2024.2424266","url":null,"abstract":"Purpose: We analysed the refractive state and the factors that influence the best-corrected visual acuity (BCVA) in congenital macular coloboma (CMC) to provide new ideas for improving and predicting the vision of patients with CMC.Methods: We reported three patients and reviewed 26 cases of CMC reported in the China National Knowledge Infrastructure (CNKI) database. We measured the BCVA, spherical equivalent refraction (SER), the macular coloboma's diameter and area, and the distance from the macular coloboma's nasal edge to the optic disc's temporal edge (DISTANCE). We analyzed the refractive status of CMC and the factors affecting BCVA.Result: The three patients with CMC we reported all had myopia. The study also included 26 patients with CMC reported in the CNKI database (9 unilateral, 17 bilateral) and we analyzed the findings of 26 patients with 43 eyes. The mean age at diagnosis was 22.96 ± 2.32 years. All patients underwent a comprehensive eye examination; 39 eyes (91%) had myopia (44% mild myopia; 28% moderate myopia; 28% high myopia); 23 eyes (53%) had a BCVA ≤6/60 and other 20 eyes (47%)>6/60. No correlation was found between SER or BCVA and the macular coloboma's diameter or area. BCVA correlated positively with DISTANCE (r = 0.603, p < 0.001). No correlation was found between SER and DISTANCE. The study found a significant difference in SER or BCVA between the affected and fellow eyes in patients with unilateral CMC (n = 9, T=-3.259, p = 0.012; Z=-2.521, p = 0.012, respectively).Conclusion: CMC seriously affects visual acuity. The refractive state is mostly myopia. We hypothesize that the DISTANCE is related to the integrity of the papillomacular bundle and affects BCVA.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"314-319"},"PeriodicalIF":1.7,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142566335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From Bench to Bedside: Unraveling Cerebral Malaria and Malarial Retinopathy by Combining Clinical and Pre-Clinical Perspectives.

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-20 DOI: 10.1080/02713683.2025.2463142

Shannon McDonnell, Ian J MacCormick, Kevin Harkin, Reinhold J Medina, Ana Rodriguez, Alan W Stitt

{"title":"From Bench to Bedside: Unraveling Cerebral Malaria and Malarial Retinopathy by Combining Clinical and Pre-Clinical Perspectives.","authors":"Shannon McDonnell, Ian J MacCormick, Kevin Harkin, Reinhold J Medina, Ana Rodriguez, Alan W Stitt","doi":"10.1080/02713683.2025.2463142","DOIUrl":"https://doi.org/10.1080/02713683.2025.2463142","url":null,"abstract":"Infection with Plasmodium falciparum carries a significant risk of cerebral malaria (CM). Children are particularly susceptible to human CM (HCM) which manifests as an acute neurovascular encephalopathy leading to high levels of mortality. Occurring in parallel with CM, malarial retinopathy (MR) is readily detected on ophthalmoscopy as one or more of: white-centered retinal hemorrhage, retinal whitening, and vessel discoloration. It leads to several distinct types of blood retinal barrier (BRB) breakdown. The precise molecular mechanisms underpinning CM and MR remain ill-defined, but parasitemia is known to drive progressive neurovascular obstruction and inflammation leading to cerebral and retinal edema and ischemia. Extensive clinical studies in patients with CM have shown that retinal examination is a useful approach for understanding pathology and an indicator for risk of mortality and morbidity. Fully understanding the cellular and molecular mechanisms that underpin CM and MR is important for developing new therapeutic approaches and in this regard the murine model of experimental CM (ECM) has proved to offer considerable value. Much is known about brain pathology in this model although much less is understood about the retina. In this review, we seek to evaluate MR in clinical scenarios and make comparisons with the retina from mice with ECM. Through detailed in vivo and post-mortem studies in the mouse and human retina, this review highlights the links between CM and MR and how this will aid our understanding of the disease progression and pathogenesis.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-15"},"PeriodicalIF":1.7,"publicationDate":"2025-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative Use of Pilocarpine After Kahook Dual Blade Goniotomy in Mild to End-Stage Glaucoma.

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-19 DOI: 10.1080/02713683.2025.2464795

Julia L Xia, Dhillon Zaver, Emmeline J Kim, Jennifer L Patnaik, Monica K Ertel, Cara E Capitena, Jeffrey R SooHoo, Malik Y Kahook, Mina B Pantcheva, Leonard K Seibold

{"title":"Postoperative Use of Pilocarpine After Kahook Dual Blade Goniotomy in Mild to End-Stage Glaucoma.","authors":"Julia L Xia, Dhillon Zaver, Emmeline J Kim, Jennifer L Patnaik, Monica K Ertel, Cara E Capitena, Jeffrey R SooHoo, Malik Y Kahook, Mina B Pantcheva, Leonard K Seibold","doi":"10.1080/02713683.2025.2464795","DOIUrl":"https://doi.org/10.1080/02713683.2025.2464795","url":null,"abstract":"Purpose: This study aims to determine if using pilocarpine postoperatively affects clinical outcomes after goniotomy.Methods: Retrospective series comparing 532 Kahook Dual Blade goniotomy (KDB-G) procedures with (P+) or without (P-) pilocarpine use in the postoperative period. This study includes patients with both primary and secondary glaucoma ranging from mild to end-stage, undergoing KDB-G with or without phacoemulsification (phaco). The primary outcome measure was surgical success defined as intraocular pressure (IOP) < 21 mmHg in addition to either a reduction of >20% and/or the reduction of ≥1 topical glaucoma medications. Secondary outcomes were mean IOP, number of medications, and rate of hyphema and IOP spike at one week postoperatively.Results: The success rate was significantly greater in Group P + at postoperative month 1 (p = .02), 3 (p = .01), 12 (p = .048), and 16 (p = .02). The differences in mean IOP (p = .084) and number of medications (p = .15) were not significantly different at one year. However, Group P + required significantly less medications than Group P - at nearly all time points (months 1, 3, 6, 20, and 24). There were no differences in rates of hyphema (p = .30) or postoperative week 1 IOP spikes (p = .66) between groups.Conclusion: The use of pilocarpine postoperatively may improve surgical success and may reduce the number of glaucoma medications needed after goniotomy.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143457199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Cyclosporine Eye Drop Use on the Success of Punctoplasty in Acquired Punctal Stenosis.

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-18 DOI: 10.1080/02713683.2025.2466659

Melek Mutlu Sönmez, Elif Ertan Baydemir

{"title":"Effects of Cyclosporine Eye Drop Use on the Success of Punctoplasty in Acquired Punctal Stenosis.","authors":"Melek Mutlu Sönmez, Elif Ertan Baydemir","doi":"10.1080/02713683.2025.2466659","DOIUrl":"https://doi.org/10.1080/02713683.2025.2466659","url":null,"abstract":"Purpose: To evaluate the effect of cyclosporine-A (CsA) 0.05% eye drops for management of acquired punctal stenosis, either alone or in combination with punctoplasty.Methods: In this prospective study patients referred to the oculoplastics clinic with acquired punctal stenosis (APS) were divided into three groups. Group A consisted of patients treated with CsA, Group B consisted of patients who underwent punctoplasty, and Group C included patients treated with both CsA and punctoplasty. Munk score, fluorescein dye disappearence test (FDDT), punctal opening grading were evaluated at baseline, and at the 1st and 6th month follow-ups.Results: One hundred-eleven eyes of 80 patients were included in the study. While the punctum grade was significantly higher, the FDDT grade and Munk scores were significantly lower in group C compared to groups A and B at the 1st and 6th month follow-ups. The functional success rate was 69%, 79%, and 88% (p = .01), and the anatomical success rate was 77%, 77%, and 90% (p = .03) in Group A, B, and C, respectively, at the 6th month follow-up.Conclusions: In the treatment of APS, the use of CsA alone and the punctoplasty procedure demonstrated comparable anatomical and functional success rates at the 6th month follow-up. However, combining CsA with punctoplasty enhances both anatomical and functional success rates.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.7,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143440095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosomes in Corneal Homeostasis and Wound Healing. 角膜稳态和伤口愈合中的外泌体

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-12 DOI: 10.1080/02713683.2025.2459335

Belinda J Hernandez, Danielle M Robertson

{"title":"Exosomes in Corneal Homeostasis and Wound Healing.","authors":"Belinda J Hernandez, Danielle M Robertson","doi":"10.1080/02713683.2025.2459335","DOIUrl":"https://doi.org/10.1080/02713683.2025.2459335","url":null,"abstract":"Purpose: The cornea is a transparent avascular tissue that serves as the first line of defense against opportunistic pathogens and provides a smooth refractive surface for vision. Due to its external location, the cornea is vulnerable to stress from the outer environment. This can lead to corneal epithelial breakdown and subsequent corneal disease. Extracellular vesicles (EVs) are nano-sized vesicles enclosed within a lipid bilayer that are secreted by all cells in the body and play a key role in cell-to-cell communication. Within the cornea field, EVs and exosomes, the latter of which represents a subpopulation of small EVs, have emerged as potential therapies for treating corneal diseases and have increased our understanding of the mechanisms by which EVs, and more specifically, exosomes released by stressed or unhealthy cells, leads to corneal dysfunction and disease.Methods: We conducted a literature search using PubMed and Google Scholar using keywords relevant to exosomes, extracellular vesicles, and cornea. We reviewed the literature focusing on EV studies on corneal wound healing and therapy.Results: This review provides a comprehensive overview of the current state of exosome biology as it relates to corneal disease and wound healing. Studies to date provide compelling data indicating that EVs and exosomes may play an integral role in the maintenance of corneal homeostasis. EVs and exosomes also have exciting potential as therapeutics in corneal wound healing and disease; and their presence in tear fluid may serve as potential diagnostic biomarkers for ocular and systemic diseases.Conclusion: While corneal exosome biology is still in its infancy state, continued progress in this area will improve our understanding of the functional capacity of these small vesicles in the human cornea and may lead to the development of novel regenerative therapies.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Mitochondrial Dysfunction During TGF-β1-Induced Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-12 DOI: 10.1080/02713683.2025.2464783

Xinyi Cheng, Xunyi Gu, Fang Wang

{"title":"Mitochondrial Dysfunction During TGF-β1-Induced Epithelial-Mesenchymal Transition in Retinal Pigment Epithelial Cells.","authors":"Xinyi Cheng, Xunyi Gu, Fang Wang","doi":"10.1080/02713683.2025.2464783","DOIUrl":"https://doi.org/10.1080/02713683.2025.2464783","url":null,"abstract":"Purpose: Epithelial-mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells contributes to the epiretinal membrane development in proliferative vitreoretinopathy (PVR). This study aimed at investigating changes in mitochondrial function during EMT in PVR.Methods: Transmission electron microscopy (TEM) was utilized to examine the mitochondrial morphology in human PVR epiretinal membranes and retinal pigment epithelium of human donor eyes. Utilizing TGF-β1 induced EMT in ARPE-19 cells as an in vitro model, we assessed mitochondrial morphology using transmission electron microscopy (TEM), evaluated mitochondrial function through various assays including detection and analysis of mitochondrial membrane potential (MMP), mitochondrial deoxyribonucleic acid (mtDNA), reactive oxygen species (ROS), ATP, oxygen consumption rate (OCR), and extracellular acidification rate (ECAR). RNA sequencing was performed to identify differentially expressed genes (DEGs) related to mitochondrial function and PVR pathogenesis.Results: Mitochondrial morphological damage was observed in human PVR epiretinal membranes. TGF-β1 treatment led to morphological changes in mitochondria, increased oxidative stress, mitochondrial membrane depolarization, and reduction in mtDNA, mitochondrial respiration, and ATP production, indicating mitochondrial dysfunction in EMT ARPE-19 cells. Furthermore, RNA sequencing data highlighted the dysfunction, showing downregulation of mitochondria-related pathways and mitochondrial transcription factor A (TFAM), crucial for mtDNA maintenance.Conclusion: Our findings indicated that TGF-β1 treatment induced mitochondrial dysfunction in RPE cells during EMT, providing insights into the molecular mechanisms of PVR development.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.7,"publicationDate":"2025-02-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Assessing the Impact of AI-Assisted Portable Slit Lamps on Rural Primary Ophthalmic Medical Service.

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-05 DOI: 10.1080/02713683.2025.2458131

Sile Yu, Chunhong Yan, Guanghao Qin, Emmanuel Eric Pazo, Xiangdong He, Peng Qi, Mingze Li, Dongming Han, Wei He, Xingru He

{"title":"Assessing the Impact of AI-Assisted Portable Slit Lamps on Rural Primary Ophthalmic Medical Service.","authors":"Sile Yu, Chunhong Yan, Guanghao Qin, Emmanuel Eric Pazo, Xiangdong He, Peng Qi, Mingze Li, Dongming Han, Wei He, Xingru He","doi":"10.1080/02713683.2025.2458131","DOIUrl":"https://doi.org/10.1080/02713683.2025.2458131","url":null,"abstract":"Purpose: To investigate the effect of an AI-assisted portable slit lamp (iSpector) and basic ophthalmology training on cataract detection, referral, and surgery rate in rural areas.Methods: This randomized control trial randomly assigned 63 village doctors to either the AI-assisted group (providing iSpector and training) or the control group (providing training). Doctors were followed for 1 year before intervention as a baseline and 1 year after to make the comparison. Multivariable Poisson regression was applied to compare the difference in cataract detection, referral, and surgery rate between the two groups, adjusted for primary doctors' baseline characteristics. We further conducted subgroup analysis to estimate the change after the intervention.Results: Compared to the control group, the detection, referral, and surgery rate of cataracts among the AI-assisted group was comparable, 1.7 times higher, and 4.9 times higher, respectively. Providing iSpector and training increased the detection, referral, and surgery rate of cataracts. However, only based on training to elevate the detection rate of cataracts did not change the referral and surgery rate.Conclusions: iSpector helps village doctors detect and refer cataract patients appropriately, thus increasing the probability that patients receive cataract surgery.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143254907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Small Extracellular Vesicles in Retinoblastoma Development and Progression. 细胞外小泡在视网膜母细胞瘤发育和发展中的作用

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-04 DOI: 10.1080/02713683.2025.2457102

Jyothi Attem, Geeta K Vemuganti

引用次数: 0

Extracellular Vesicles and Glaucoma: Opportunities and Challenges.

IF 1.7 4区医学

Current Eye Research Pub Date : 2025-02-03 DOI: 10.1080/02713683.2025.2459888

Mofazzal Hossain, Yutao Liu

{"title":"Extracellular Vesicles and Glaucoma: Opportunities and Challenges.","authors":"Mofazzal Hossain, Yutao Liu","doi":"10.1080/02713683.2025.2459888","DOIUrl":"https://doi.org/10.1080/02713683.2025.2459888","url":null,"abstract":"Purpose: Glaucoma is one of the leading causes of irreversible blindness, characterized by progressive visual field loss. Several risk factors are associated with developing the disease. However, the exact mechanisms or pathological pathways involved are still unknown. There is an urgent need to find the mechanisms and biomarkers for early detection and therapy to halt progression or cure the disease. Extracellular vesicles (EVs), specifically exosomes, have emerged as a crucial player in all aspects of glaucoma, including pathogenesis to therapeutic application with their cell-cell communication properties.Methods: We performed a literature search on PubMed, Google Scholar, and Web of Science using different keywords. Next, we reviewed the literature with studies focusing on the role of EVs as a causative factor in disease progression, biomarker discovery based on their contents, and protection from glaucoma.Results: Studies summarized here provide reports of differential EV miRNA and protein expression alterations when communicating with aqueous humor drainage tissues. We described how EV contents are involved in various pathways, including extracellular matrix remodeling and miRNA-mediated oxidative stress transmission between outflow tissues, thereby contributing to glaucoma. Extracellular vesicles, mainly derived from mesenchymal stem cells protecting the optic nerve from degeneration, have also been discussed as potential therapies for glaucoma.Conclusions: Overall, this review provides a comprehensive discussion of the role of extracellular vesicles in glaucoma. We identified the challenges in finding major signaling molecules of glaucoma etiology. Lastly, we highlighted future directions to improve the treatment of glaucoma by extracellular vesicles.","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-10"},"PeriodicalIF":1.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0