Current Eye Research最新文献

{"title":"Meta-Analysis of the Association Between <i>VEGF</i>-2578C/A Polymorphism and Susceptibility to Type 2 Diabetic Retinopathy.","authors":"Dingyong Wu, Wanting Li","doi":"10.1080/02713683.2025.2451616","DOIUrl":"10.1080/02713683.2025.2451616","url":null,"abstract":"<p><strong>Purpose: </strong>to investigate the association between vascular endothelial growth factor (<i>VEGF)</i>-2578C/A polymorphism and susceptibility to type 2 diabetic retinopathy (T2DR) by meta-analysis.</p><p><strong>Methods: </strong>According to the search strategy, Four databases were retrieved to identify the literature on the relationship between <i>VEGF</i> polymorphism and the risk of T2DR from inception to July 2024. Stata 15.0 was used for data processing.</p><p><strong>Results: </strong>Ten articles were involved in this review, covering 1390 cases and 1306 controls. The pooled results exhibited that the risk of T2DR was associated with <i>VEGF</i>-2578C/A polymorphism under the allele model (A/C: OR= 1.33, 95%CI: 1.04-1.72, <i>p</i> = 0.025) and dominant models (AA+CA/CC: OR= 1.38, 95%CI: 1.00-1.91, <i>p</i> = 0.047). However, in recessive, homozygous, and heterozygous models, no significant difference was observed (all <i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>The <i>VEGF</i>-2578C/A polymorphism is associated with susceptibility to T2DR. In particular, allele A and genotype AA+CA at the <i>VEGF</i>-2578C/A locus were significantly associated with an increased risk of T2DR.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"559-566"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of Keratoconus Progression Rate between Adolescents Aged 19-24 Years and Young Adults: Impact on Indication for Crosslinking.","authors":"Pinar Kosekahya, Elias Flockerzi, Cristian Munteanu, Haris Sideroudi, Berthold Seitz","doi":"10.1080/02713683.2025.2470408","DOIUrl":"10.1080/02713683.2025.2470408","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the keratoconus characteristics and progression rate in a patient group of adolescents aged 19-24 years and to compare the results with young adults aged 25-30 years.</p><p><strong>Methods: </strong>A total of 158 keratoconic eyes (82 and 76 eyes in the adolescent and young adult groups) of the Homburg Keratoconus Center, which were examined by Scheimpflug tomography at least two times, were included in this retrospective study. The visual characteristics, corneal tomography, and biomechanical measurements were noted at the initial visit, 6 months, 12 months, and 24 months after the initial visit. Progression rates and the amounts of change were calculated and compared between groups.</p><p><strong>Results: </strong>Baseline visual, tomographical, and biomechanical characteristics along with keratoconus staging were similar between groups at the initial visit (<i>p</i> > .05 for all values). Progression rate was 76.8% vs 14.9% with respect to Kmax change, 72.3% vs 12.0% with respect to ABC parameters, and 26.4% vs 16.4% with respect to E staging in the adolescent vs young adult groups, respectively (<i>p</i> < .001, <i>p</i> < .001, and <i>p</i> = .25).</p><p><strong>Conclusions: </strong>Keratoconus may worsen more rapidly in adolescent patients aged 19-24 years compared to young adult patients aged 25-30 years. This study emphasizes the high progression rate in adolescent patients and the consideration of early cross-linking and/or at least closer follow-ups in this age group.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"572-578"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Biomarkers for Screening Retinal Detachment Associated with Choroidal Detachment Using DIA-MS-Based Proteomics.","authors":"Pingping Li, Mengyao Han, Rui Zhang, Fangyu Chen, Yanzi Li, Jing Yuan, Ning Ma, Lu Li, Jianhua Wu","doi":"10.1080/02713683.2025.2469228","DOIUrl":"10.1080/02713683.2025.2469228","url":null,"abstract":"<p><strong>Purpose: </strong>Rhegmatogenous retinal detachment associated with choroidal detachment (RRDCD) is known for its rapid progression and poor prognosis, making it a subject of significant clinical interest due to its complex pathogenesis. This study aims to utilize mass spectrometry for proteomic analysis of vitreous humor to identify proteins and biomarkers critical to the pathophysiology of RRDCD.</p><p><strong>Methods: </strong>Data-independent acquisition (DIA) mass spectrometry was employed to analyze vitreous humor samples from RRDCD and Rhegmatogenous retinal detachment (RRD) patients. The analysis focused on identifying differentially expressed proteins (DEPs) and determining their functional roles. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to explore the biological processes and pathways associated with these DEPs. DEPs were validated using ELISA to confirm the reliability of the mass spectrometry results.</p><p><strong>Results: </strong>A total of 237 DEPs were identified, including 63 upregulated and 174 downregulated proteins. GO functional analysis showed enrichment in terms related to molecular function regulators, biological adhesion, and the extracellular region. KEGG pathway analysis revealed significant associations with the Extracellular environment (ECM)-receptor interaction, complement and coagulation cascades, and lysosome pathways. Receiver operating characteristic (ROC) analysis further confirmed that Serum amyloid A-4 protein (SAA4), Inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1), and Vitronectin (VTN) exhibit excellent performance in the diagnosis of RRDCD. Both VTN and SAA4 showed positive correlations with BCVA at 6 months post-surgery.</p><p><strong>Conclusion: </strong>RRDCD activates a variety of cellular pathways, not only complement and inflammation, but also the remodeling of the extracellular matrix and the activation of lysosome-related pathways disrupt normal retinal cell function. SAA4, ITIH1, and VTN in vitreous fluid can serve as effective biomarkers for diagnosing patients with RRDCD. Additionally, both VTN and SAA4 are correlated with post-operative visual outcomes.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"641-650"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514908","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Innovative Famciclovir Eye Drop Formulations for Herpes Zoster Infections.","authors":"Iris M Domenech-Monsell, Adrián M Alambiaga-Caravaca, Lucía Bernat-Just, Virginia Merino, Vicent Rodilla, Cristina Balaguer-Fernández, Alicia López-Castellano","doi":"10.1080/02713683.2025.2472363","DOIUrl":"10.1080/02713683.2025.2472363","url":null,"abstract":"<p><strong>Purpose: </strong>Herpes zoster ophthalmicus, a manifestation of the varicella-zoster virus in the eye, presents significant clinical challenges. As there is no direct ocular treatment for this infection, new therapeutic options should be studied. Famciclovir, a widely used antiviral drug for herpes zoster, offers higher bioavailability than acyclovir (a common herpes zoster treatment). However, this drug is currently limited to oral dosage forms, which are associated with inherent limitations such as variable absorption or gastrointestinal side effects. This study aimed to formulate new famciclovir eye drops for controlled drug release and targeted delivery to the cornea and sclera.</p><p><strong>Method: </strong>Eye drop formulations containing various polymers (polyvinyl alcohol, hydroxypropyl methyl cellulose and chitosan) were developed and evaluated for physicochemical properties, irritation index and stability. The best performing formulation was used in <i>ex-vivo</i> diffusion and retention studies with rabbit cornea and sclera. The results were analyzed with a new HPLC validation method.</p><p><strong>Results: </strong>The formulation with polyvinyl alcohol exhibited superior properties regarding transparency, turbidity and absence of bubbles. It maintained a physiological pH over time and had an appropriate viscosity of 19.97 ± 0.25 mPa<b>^.</b>s. Non-irritancy was confirmed by the HET-CAM test, and the formulation was stable at room temperature (25 °C), fridge (4 °C) and freezer (-80 °C). <i>Ex- vivo</i> diffusion studies revealed higher diffusion through the sclera compared to the cornea, with greater drug accumulation in sclera.</p><p><strong>Conclusions: </strong>These findings suggest that famciclovir eye drops may offer a viable treatment for ocular herpes zoster infections. Famciclovir also diffuses and retains in targeted membranes, possibly enhancing its therapeutic effects.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"590-599"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536756","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tear-Driven Phase Transition Microemulsion for Ocular Delivery of Dexamethasone in the Effective Treatment of Uveitis.","authors":"Nivedita Gautam, Priya Sharma, Neelima Yadav, Jothimani Rajeswari, Karthikeyan Kesavan","doi":"10.1080/02713683.2025.2469243","DOIUrl":"10.1080/02713683.2025.2469243","url":null,"abstract":"<p><strong>Purpose: </strong>The goal of this study was to develop dexamethasone-loaded tear-driven phase transition microemulsions (PTMEs) to effectively treat uveitis.</p><p><strong>Methods: </strong>PTMEs were prepared using the oil titration method. Physicochemical parameters, <i>in vitro</i> release, and ocular irritation studies were performed. The <i>in vivo</i> study, total cell count, and total protein content were estimated on the rabbit eye model.</p><p><strong>Results: </strong>The study revealed that developed PTMEs had nanoglobule sizes, acceptable physicochemical properties, and prolonged drug release. Ex-vivo and in-vivo studies concluded that higher permeability and improved anti-inflammatory properties were observed for PTMEs compared to marketed formulation.</p><p><strong>Conclusion: </strong>The prepared PTMEs showed a sustained release pattern and enhanced therapeutic effectiveness, making them a promising alternative to conventional eye drops for treating uveitis.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"631-640"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the Effects of Timolol, Brinzolamide, Brimonidine and Netarsudil in a Rabbit Model of Water Loading-Induced Ocular Hypertension.","authors":"Junya Maruoka, Yasuhiro Takeji, Daisuke Yamashita, Keisuke Hino, Shinsaku Itoh, Yusuke Kakumoto, Kazushi Sakurai, Hiroki Urashima","doi":"10.1080/02713683.2025.2472365","DOIUrl":"10.1080/02713683.2025.2472365","url":null,"abstract":"<p><strong>Purpose: </strong>This study aimed to compare the intraocular pressure (IOP)-lowering effects of timolol (a β-blocker), brinzolamide (a carbonic anhydrase inhibitor), brimonidine (an α2-agonist) and netarsudil (a rho kinase inhibitor) in rabbits.</p><p><strong>Methods: </strong>The experiments were performed on 52 female New Zealand white rabbits. The IOP was measured in normotensive rabbits and in water loading-induced ocular hypertension model rabbits. Thirty microliters of timolol, brinzolamide, brimonidine, netarsudil or saline was administered topically to the randomly chosen eye. Ocular hypertension was induced by the oral administration of 60 mL/kg of tap water.</p><p><strong>Results: </strong>In normotensive rabbits, the maximum IOP-lowering effects of timolol, brinzolamide, brimonidine, and netarsudil were 2.9 mmHg (2 h), 5.2 mmHg (1 h), 5.7 mmHg (2 h), and 3.3 mmHg (4 h), respectively. In water loading-induced ocular hypertension model rabbits, the maximum IOP-lowering effects of timolol, brinzolamide, brimonidine, and netarsudil were 3.6, 5.0, 12.2, and 5.0 mmHg, respectively. The IOP-lowering effects of brimonidine and netarsudil were sustained until 90 min after water loading.</p><p><strong>Conclusion: </strong>This study showed that timolol, brinzolamide, brimonidine and netarsudil have IOP-lowering effects in normotensive rabbits and in water loading-induced ocular hypertension model rabbits. In an ocular hypertension rabbit model, brimonidine and netarsudil, which promote aqueous humor outflow, exhibited stronger IOP-lowering effects than timolol and brinzolamide, which suppress aqueous humor production. These results could provide data for characterizing each medication. These data may aid in the development of new glaucoma medications through the combination of existing medications.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"618-623"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Neurotization in Elderly Patients with Multimorbidity.","authors":"Christoph Holtmann, Mathias Roth, Kerim Beseoglu, Maria Borrelli, Gerd Geerling","doi":"10.1080/02713683.2025.2509567","DOIUrl":"https://doi.org/10.1080/02713683.2025.2509567","url":null,"abstract":"<p><strong>Purpose: </strong>Corneal neurotization (CN) is a surgical technique to improve corneal sensitivity and the ocular surface in eyes with neurotrophic keratopathy. It has been predominantly advocated in patients with congenital corneal hypesthesia. Neurotrophic keratopathy is however much more frequent at an older age and in often multimorbid patients. We report our experience with corneal neurotization in patients with multimorbidity.</p><p><strong>Methods: </strong>Seven eyes of 5 patients (f:m = 2:3, median age 70 ± 12 years) suffering from neurotrophic keratopathy due to Diabetes mellitus (<i>n</i> = 3), post Herpes Zoster keratitis (1) and drug use (1) were treated with direct CN using the supraorbital nerve (<i>n</i> = 5) or indirect CN (<i>n</i> = 2, with sural nerve interponate) and followed for a median of 7 months. In one case, a femtosecond laser was used to create peripheral intrastromal corneal pockets. Documented parameters included corneal sensitivity tested with a Cochet Bonnet aesthesiometer in four quadrants and the corneal center pre- and postoperatively, stage of NK, and duration of surgery.</p><p><strong>Results: </strong>Corneal sensitivity was 0 mm in all areas tested of all corneas prior to neurotization (stage 3 NK). Mean surgical time was 247 ± 53 min. At 3 months, it was improved in 63% of all areas tested (5/7 eyes). In two eyes, severe neurotrophic keratopathy recurred (stage 3 NK). Three out of the five patients died of general conditions during follow-up.</p><p><strong>Conclusion: </strong>Corneal neurotization is a resource intensive technique, which successfully can improve corneal sensitivity. We also for the first time used a femtosecond laser to create peripheral intrastromal corneal pockets. When offering CN to elderly patients the long time to more profound corneal reinnervation, required to prevent corneal perforation, and generally potential fatal comorbidities should be considered carefully. Given the good results reported for younger patients the procedure should be indicated probably earlier in the course of the disease.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144198370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anterior Segment Measurement and Reproducibility in Pediatric Eyes Using Quantitative Ultrasound Biomicroscopy.","authors":"Trisha Miglani, Michael Chang, Libby Wei, Dhruv Shah, Taylor Kolosky, Moran R Levin, Alfred Vinnett, Camilo Martinez, Marlet Bazemore, Mohamad Jaafar, William Madigan, Janet L Alexander","doi":"10.1080/02713683.2025.2503207","DOIUrl":"https://doi.org/10.1080/02713683.2025.2503207","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study is to provide an evidence-based protocol for iris measurement from ultrasound biomicroscopy (UBM) images with reproducibility analysis and resulting normative iris thickness dataset of the pediatric human iris by age.</p><p><strong>Methods: </strong>Healthy pediatric subjects (14 subjects, 25 eyes, mean age 2.0 ± 1.2 years) were recruited prospectively and underwent UBM imaging. Iris parameters were measured in 4 UBM images per eye in raw image and processed edge detection format. Agreement and variability were evaluated. Regression assessed the association between measurement differences and the variables expected to influence measurement reproducibility (image quality, orientation, and processing). Iris thickness by age was reported.</p><p><strong>Results: </strong>Intraclass correlation was >0.6 and correlation was >0.7 for all parameters. Coefficient of variation was <30% for iris measurements not involving the ciliary body. Image quality improved reproducibility but was not statistically significant (<i>p</i> = 0.10). Age of subject, edge detection, and image orientation were also not significant. Iris thickness increased with increasing age (<i>r</i> = 0.63, <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>This study demonstrated reproducible iris measurements using a prospective protocol. We found image features, including image quality and edge detection pre-processing, were not critical to reproducibility. In the future, clinical correlations with iris morphology may be more rigorously studied using a well-defined, reproducible, and quantitative approach as presented in this UBM-based image analysis protocol.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":1.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Role of IDO Activity in Cataract Progression: Correlation to Age and Cataract Severity.","authors":"Arturs Zemitis, Juris Vanags, Kristaps Klavins, Guna Laganovska","doi":"10.1080/02713683.2025.2506118","DOIUrl":"https://doi.org/10.1080/02713683.2025.2506118","url":null,"abstract":"<p><strong>Purpose: </strong>Cataract is a prevalent, progressive lens disorder characterized by gradual opacity, often related to aging. Oxidative stress, ultraviolet radiation, and inflammation contribute to lens damage and protein modifications. Indoleamine 2,3-dioxygenase plays a critical role in tryptophan metabolism, with kynurenines implicated in various diseases. This study aimed to assess IDO activity in cataract patients by analyzing IDO activity in aqueous humor.</p><p><strong>Methods: </strong>The study included 170 cataract surgery patients (60 males, 110 females; mean age 73.9 ± 9.43 years). Cataract severity was categorized using the SPONCS system: SPONCS 1 (1.8%), SPONCS 2 (30.6%), SPONCS 3 (35.3%), SPONCS 4 (11.8%), and SPONCS 5 (20.6%). Aqueous humor samples (50-120 µL) were collected <i>via</i> paracentesis and analyzed using HILIC liquid chromatography with mass spectrometry. Target metabolite quantification was performed using internal standards and calibration curves.</p><p><strong>Results: </strong>Significant differences in IDO activity were observed across SPONCS groups (X²(4) = 12.0, <i>p</i> = .018, Ɛ²= 0.0707), particularly between SPONCS 2 and SPONCS 5 (<i>p</i> = .013). Age differences across SPONCS groups were also significant (<i>p</i> < .001). Males had lower tryptophan levels than females (<i>p</i> = .027). Correlations were found between SPONCS and IDO activity (r_s = -0.255, <i>p</i> < .001), SPONCS and kynurenine (r_s = 0.196, <i>p</i> = .011), and kynurenic acid with kynurenine (r_s = 0.355, <i>p</i> < .001).</p><p><strong>Conclusion: </strong>Patients with SPONCS 2 cataract exhibit increased susceptibility to elevated IDO activity and heightened kynurenine production. IDO serves as a more reliable prognostic marker for cataract progression than chronological age. Furthermore, IDO activity may be associated with reduced glutathione levels in human lens epithelial cells, suggesting a potential link between the enzyme and oxidative stress within the lens.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-7"},"PeriodicalIF":1.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Scleral Rigidity and Corneal Stress-Strain Measurements with Induced Elevation of Intraocular Pressure in Healthy Eyes.","authors":"Graziela Boschetti, Valeria Batista Boreck Seki, Tiago Santos Prata, Jayter Silva Paula","doi":"10.1080/02713683.2025.2509565","DOIUrl":"https://doi.org/10.1080/02713683.2025.2509565","url":null,"abstract":"<p><strong>Purpose: </strong>To correlate scleral rigidity and corneal stiffness parameters with induced elevation of intraocular pressure (IOP) in healthy subjects using an ophthalmodynamometer.</p><p><strong>Methods: </strong>A combined calculation of applanation and indentation tonometric measurements using the Calixto nomogram was used to estimate scleral rigidity (SR) in healthy adults. The stiffness parameter (at first applanation - SP-A1), stress-strain index (SSI), and central corneal thickness were determined using the Corvis ST. Then, all eyes underwent acute IOP elevation through ocular compression using an ophthalmodynamometer at four crescent steps. Univariate and multivariate regression analyses were used to investigate the association between intraocular pressure increase and ocular biomechanical parameters.</p><p><strong>Results: </strong>Fifty-four eyes from 27 participants were included (mean age, 55.9 ± 9.9 years). The mean baseline IOP was 12.9 mmHg. The average values for SR, SP-A1, and SSI were 0.025 AU, 113.8 mmHg/mm, and 1.28, respectively. During ocular compression, IOP significantly increased in all eyes (mean change, 22.4 ± 4.3 mmHg; <i>p</i> < 0.001). The multivariable analysis showed that the magnitude of the rise in IOP was correlated only with SR (coefficient= 178.35; <i>p</i> = 0.03).</p><p><strong>Conclusions: </strong>Scleral, but not corneal, biomechanical parameters correlate independently with the magnitude of acute IOP increase in healthy eyes. These findings support further biomechanical studies involving patients with glaucoma to better understand the relationship between ocular compliance and its mechanical response to different IOP levels.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-6"},"PeriodicalIF":1.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}