Current Eye Research最新文献

{"title":"Effect of Repeated Intense Foveal Red-Light Therapy in Children with Pre-Myopia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.","authors":"Matheus Henrique Monteiro Leber, Tanize Louize Milbradt, Alexandre Yamada Fujimura, Yasmin Picanco Silva, Dillan Cunha Amaral, Henrique Monteiro Leber, Rubens Belfort","doi":"10.1080/02713683.2025.2516007","DOIUrl":"10.1080/02713683.2025.2516007","url":null,"abstract":"<p><strong>Purpose: </strong>Myopia is a significant public health concern with increased risk of ocular complications. Intense Foveal Red Light (IFRL) therapy has been explored in myopia control, but its efficacy at the pre-myopic stage remains underexplored. The use of this therapy in a population without a myopia diagnosis may offer a new window for the prophylactic application of IFRL therapy. The purpose of this meta-analysis is to determine the effectiveness of IFRL therapy in children with pre-myopia.</p><p><strong>Methods: </strong>PubMed, Embase, and the Cochrane Library were systematically searched for studies investigating the effects of IFRL therapy on myopia incidence, changes in axial length (AL), choroidal thickness (CT), and cycloplegic spherical equivalent refraction (SER). Two independent reviewers screened studies, extracted data, and assessed the risk of bias. Meta-analyses were conducted using random-effects models to estimate the pooled effect sizes.</p><p><strong>Results: </strong>Of 365 studies identified, 4 met the criteria, totaling 619 participants (mean age 8.48 years, 51.8% female). At 6 months, IFRL significantly reduced myopia incidence (Risk Difference [RD] - 0.1; 95% CI -0.15 to -0.05; <i>p</i> < 0.01), with benefits persisting at 12 months (RD -0.17; 95% CI -0.26 to 0.09; <i>p</i> < 0.01). IFRL also reduced AL at 6 months (Mean Difference [MD] - 0.12 mm; 95% CI -0.16 to -0.09; <i>p</i> < 0.01) and 12 months (MD -0.18 mm; 95% CI -0.23 to -0.14; <i>p</i> < 0.01), increased CT (MD 22.34 µm; 95% CI 5.45-39.24; <i>p</i> < 0.01), and improved SER at 6 (MD 0.27 D; 95% CI 0.23 to 0.32; <i>p</i> < 0.01) and 12 months (MD 0.36 D; 95% CI 0.27-0.46; <i>p</i> < 0.01).</p><p><strong>Conclusion: </strong>IFRL effectively reduced myopia incidence, AL, and improved SER and CT. These findings support further research on its long-term efficacy and safety, particularly regarding potential adverse effects and durability of outcomes. Overall, IFRL may offer a preventive strategy for pre-myopic children.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1085-1093"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Effect of Nephropathy and Neuropathy on Response to Short-Term Intravitreal Anti-Vegf Treatment in Diabetic Macular Edema: An Optical Coherence Tomography-Angiography Study.","authors":"Buse Oz Onar, Sevcan Balci, Yilmaz Cetinkaya, Melike Betul Ogutmen, Nursal Melda Yenerel","doi":"10.1080/02713683.2025.2533345","DOIUrl":"10.1080/02713683.2025.2533345","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of nephropathy and neuropathy on short-term anatomical and functional responses to intravitreal anti-VEGF treatment in patients with diabetic macular edema (DME), using optical coherence tomography angiography (OCTA).</p><p><strong>Materials and methods: </strong>This prospective study included 34 eyes from 34 DME patients who received three monthly intravitreal anti-VEGF injections. Patients were stratified based on renal function (eGFR ≥90 vs. <90 mL/min/1.73 m²; UACR <30 vs. ≥30 mg/g) and the presence of diabetic neuropathy confirmed by EMG. Functional (BCVA) and anatomical (central macular thickness, vessel densities in the superficial and deep capillary plexus, and FAZ area) changes were compared across subgroups using OCTA at baseline and 3 months.</p><p><strong>Results: </strong>Of all patients, BCVA improved significantly (<i>p</i> < 0.05) and central macular thickness (CMT) decreased significantly (<i>p</i> < 0.01) after treatment. However, eyes with nephropathy (eGFR <90) showed smaller reductions in CMT compared to those without nephropathy, though the difference was not statistically significant (<i>p</i> = 0.68). Patients with neuropathy showed less improvement in BCVA and reduced changes in superficial and deep vessel densities. OCTA parameters showed modest, variable responses across all subgroups.</p><p><strong>Conclusions: </strong>Nephropathy and neuropathy do not seem to affect the functional recovery response to short-term intravitreal anti-VEGF therapy for DME. Nephropathy affects peripapillary vascular density.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1139-1146"},"PeriodicalIF":2.0,"publicationDate":"2025-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Refractive Changes Induced by Ophthalmic Viscosurgical Devices in Cataract Surgery.","authors":"Luiz Felipe Fontella Souza, Pedro Carlos Carricondo, Bernardo Kaplan Moscovici, Cesar Martins Cortez Vilar, Larissa Gouvea, Wilson Takashi Hida","doi":"10.1080/02713683.2025.2574886","DOIUrl":"https://doi.org/10.1080/02713683.2025.2574886","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the refractive changes induced by ophthalmic viscosurgical devices (OVDs) in the anterior chamber after intraocular lens (IOL) implantation using intraoperative aberrometry (IA).</p><p><strong>Methods: </strong>A nonrandomized prospective interventional case series of ten consecutive patients undergoing routine cataract surgery was conducted. Exclusion criteria included previous ocular surgery, corneal opacities, vitreous or macular lesions, and extreme axial lengths. Intraoperative refractive measurements were taken using IA after IOL implantation with cohesive (Provisc, Alcon), intermediate (Vistagel, Johnson & Johnson), and dispersive (Viscoat, Alcon) OVDs. Balanced Salt Solution (BSS) was used as a control. Statistical analysis compared refractive deviations across OVDs.</p><p><strong>Results: </strong>Provisc, a cohesive OVD, demonstrated the least refractive deviation (median SE -1.0 D) and minimal impact on refractive outcomes. Viscoat, a highly dispersive OVD, induced the greatest refractive deviation (median SE -1.7 D) compared to the control with BSS (median SE -0.1 D). Statistically significant differences in refractive deviations were observed among the tested OVDs compared to BSS (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>This study demonstrates that OVD choice significantly influences refractive outcomes in cataract surgery. Provisc (cohesive) produced the smallest refractive deviation (median SE -1.0 D), whereas Viscoat (dispersive) caused the greatest deviation (median SE -1.7 D) compared with BSS (-0.1 D). These findings underscore the importance of careful OVD selection to optimize refractive precision and highlight the need for further research in diverse surgical settings.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-5"},"PeriodicalIF":2.0,"publicationDate":"2025-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145353778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Experimental Study on the Widely Used Chemotherapeutic Docetaxel: Does It Induce Inflammation, Ischemia, and Neurodegeneration in the Eye, Causing Dry Eye and Blurred Vision in a Real-Life Scenario?","authors":"Ayse Ipek Akyuz Unsal, Fadime Kahyaoglu, Sayime Aydin Eroglu, Tuna Onal, Bilgin Demir, Sabri Barutca, Buket Demirci","doi":"10.1080/02713683.2025.2575785","DOIUrl":"https://doi.org/10.1080/02713683.2025.2575785","url":null,"abstract":"<p><strong>Purpose: </strong>Chemotherapy protocols for lung, breast, and prostate cancer include Docetaxel (DTX). Several case series have reported ophthalmic side effects of DTX, such as epiphora and blurred vision, which significantly affect quality of life. This experimental study aims to investigate the potential histopathological impacts of DTX on ocular structures.</p><p><strong>Methods: </strong>A DTX-treated group consisting of male Wistar rats aged 6 to 8 months (<i>n</i> = 7) received intraperitoneal administration of 10 mg/kg DTX three times on days 0, 8, and 15. A control group (<i>n</i> = 6) received weekly intraperitoneal injections of physiological saline. On the 22nd day, ocular tissues were evaluated using hematoxylin and eosin (H&E) staining, along with immunohistochemical analysis of iNOS, eNOS, IL-6, TGF-β, VEGF, and TUNEL markers.</p><p><strong>Results: </strong>The main outcomes observed through H&E evaluation revealed corneal neovascularization, inflammatory cells with cystic dilatations in the lacrimal gland, and degeneration of the retinal nerve fiber layer. DTX treatment significantly increased the levels of iNOS, eNOS, IL-6, TGF-β, VEGF, and apoptosis markers compared to the control group.</p><p><strong>Conclusions: </strong>This experimental study demonstrated that DTX induces inflammation and ischemia in ocular tissues, as shown in histopathological sections. Given the rising incidence of cancer and the related use of chemotherapeutics, it is crucial for ophthalmologists to recognize the ocular side effects of drugs like DTX in order to enhance the quality of life for cancer patients undergoing chemotherapy.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145344039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overexpression of Ku80 Protects Lens Epithelial Cells from Selenium-Induced Cataract Formation by Regulating the DNA Damage Response.","authors":"Pingping Chen, Xiaotian Liu, Kan Chen, Shanjun Wu, Hongyan Yao, Qianjie Yang, Yun Wang, Yiming Wang, Qinyi Gu, Jianshu Yuan","doi":"10.1080/02713683.2025.2575784","DOIUrl":"https://doi.org/10.1080/02713683.2025.2575784","url":null,"abstract":"<p><strong>Purpose: </strong>DNA damage and repair defects in lens epithelial cells (LECs) contribute to the formation and progression of age-related cataracts (ARC). Ku antigen 80 kDa (Ku80) plays an important role in the non-homologous end-joining (NHEJ) pathway for repairing DNA double-strand breaks, while the Cockayne Syndrome Complementary B (CSB) protein plays a critical role in the nucleotide excision repair pathway. This study evaluates the protective effect of AAV-mediated overexpression of Ku80 in rat LECs and explores its contribution to delaying selenium-induced cataract formation.</p><p><strong>Methods: </strong>SD rats (11 days) were randomly divided into three groups: control group (<i>n</i> = 7), AAV-NC group (<i>n</i> = 14), and AAV-Ku80 group (<i>n</i> = 14). The AAV-Ku80 group received adenovirus-mediated overexpression of Ku80, the AAV-NC group received adenoviral vector negative control, and the control group was injected with physiological saline. All injections were performed in the anterior chamber. Except for the control group, the other two groups were subcutaneously injected with sodium selenite solution into the nape of the neck 30 min after the injection. The degree of lens opacity was examined using a slit-lamp, and lenses were harvested to assess antioxidant parameters, including superoxide dismutase (SOD) activity, reduced glutathione (GSH) content, and the oxidative damage marker malondialdehyde (MDA) content. Western blot analysis was performed to examine the upregulation of CSB protein and its association with delayed cataract formation.</p><p><strong>Results: </strong>Overexpression of Ku80 significantly enhanced the expression of CSB protein, improved DNA repair capacity, and mitigated the influences of oxidative stress on rat LECs. This resulted in a significant increase in SOD and GSH levels, a significant decrease in MDA levels, and postponed the onset of selenium-induced cataracts, hence preserving lens clarity. Moreover, Ku80 overexpression partially alleviated damage to the corneal endothelium and retina.</p><p><strong>Conclusion: </strong>Ku80 overexpression alleviates damage to LECs and postpones the development of selenium-induced cataracts by increasing CSB protein levels and controlling DNA repair processes. This research underscores the significant therapeutic potential of Ku80 in postponing cataract formation and may offer new avenues for gene therapy in the prevention and treatment of cataracts.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-10"},"PeriodicalIF":2.0,"publicationDate":"2025-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nitrosative Stress, Mitochondrial Peptides, and Ferroptosis Markers in Corneal Epithelial Cells from Keratoconus Patients.","authors":"Cahit Demirkiran, Alper Mete, Abdullah Tuncay Demiryürek, Ahmet Saracaloglu, Şeniz Demiryürek","doi":"10.1080/02713683.2025.2570815","DOIUrl":"https://doi.org/10.1080/02713683.2025.2570815","url":null,"abstract":"<p><strong>Purpose: </strong>To investigate the possible contribution of nitrosative stress, mitochondrial peptide levels (humanin and mitochondrial open-reading frame of the 12S rRNA-c), and ferroptosis parameters in corneal epithelial cells obtained from patients with keratoconus.</p><p><strong>Methods: </strong>This prospective study was conducted on corneal epithelial cell samples taken from 75 adult patients with keratoconus and 25 age-matched postmortem controls. The Amsler-Krumeich classification was used for staging the keratoconus. All parameters, except nitric oxide, were measured by ELISA, and nitric oxide levels were determined by the chemiluminescence method.</p><p><strong>Results: </strong>Humanin levels in keratoconus corneal epithelial cells were increased in stage 3 (<i>p</i> < .05), while mitochondrial open-reading frame of the 12S rRNA-c (<i>p</i> < .01) levels were diminished in all stages. Significant increases in nitric oxide (<i>p</i> < .001) and 3-nitrotyrosine (<i>p</i> < .05) levels were detected in the keratoconus group, indicating the involvement of nitrosative stress. In stage 3, glutathione peroxidase 4 levels were shown to be decreased (<i>p</i> < .01), while long-chain fatty acid CoA ligase 4 (<i>p</i> < .05) and malondialdehyde (<i>p</i> < .05) levels were increased.</p><p><strong>Conclusion: </strong>This is the first study to show that humanin and mitochondrial open-reading frame of the 12S rRNA-c can participate in the pathophysiology of keratoconus. In addition to the mitochondrial peptides, our data suggest that increased nitrosative stress and ferroptosis may contribute to the pathophysiology of keratoconus.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental Use of Ozone in Cross-Linking: Transforming Keratoconus Management.","authors":"Aysun Sanal Dogan, Canan Gurdal, Sinan Caliskan, Evrim Onder, Atilla Isgoren, Hilal Toprak Tellioglu","doi":"10.1080/02713683.2025.2569058","DOIUrl":"https://doi.org/10.1080/02713683.2025.2569058","url":null,"abstract":"<p><strong>Purpose: </strong>Keratoconus is a progressive corneal disorder characterized by thinning of the stromal layer. Corneal cross-linking (CXL), a widely used treatment, focuses on improving corneal strength by enhancing collagen cross-links. Alternative methods are being explored to increase the efficacy of CXL. This study aims to evaluate whether ozone, as a strong oxygen donor, can be utilized as an adjuvant or standalone cross-linking agent in an <i>in vivo</i> model.</p><p><strong>Methods: </strong>The study involved 12 New Zealand albino rabbits, which were divided into three treatment groups, each receiving a different therapy: (1) CXL, (2) ozone, and (3) CXL combined with ozone (CXL+ozone). Corneal Visualization Scheimpflug Technology (Corvis ST), Anterior Segment Optical Coherence Tomography (AS-OCT), and Corneal Confocal Microscopy (CCM) measurements were performed post-procedure.</p><p><strong>Results: </strong>Ozone therapy did not result in statistically significant differences compared to CXL in biomechanical parameters. Corvis ST measurements were not significantly different between groups. AS-OCT revealed full-thickness stromal brightness in the CXL+ozone group. CCM imaging showed hyperreflectivity limited to the anterior stroma in the CXL and ozone groups but distributed throughout the stroma in the CXL+ozone group. No adverse effects were observed.</p><p><strong>Conclusion: </strong>Ozone therapy may enhance CXL efficacy and serves as a potential alternative. Its affordability, shorter duration, and comparable clinical outcomes make it particularly promising for resource-limited settings.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-7"},"PeriodicalIF":2.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nd:YAG Laser Induced Microfragmentation in Intraocular Lenses: A Correlative Optical and Raman Spectroscopy Study.","authors":"Andreas F Borkenstein, Eva-Maria Borkenstein, Leon Ranz, Sara Korenjak Jausnik, Christian Neuper, Harald Fitzek","doi":"10.1080/02713683.2025.2572024","DOIUrl":"https://doi.org/10.1080/02713683.2025.2572024","url":null,"abstract":"<p><strong>Purpose: </strong>Neodymium-doped yttrium-aluminum-garnet (Nd:YAG) laser capsulotomy is among the most frequently performed postoperative procedures in pseudophakic patients. Despite its widespread use and generally favorable safety profile, its potential to release solid-phase polymer debris from intraocular lenses (IOLs) has not been fully characterized. In this study, we investigated whether clinically relevant laser settings can cause the liberation of detachable fragments from both hydrophobic and hydrophilic acrylic IOLs.</p><p><strong>Methods: </strong>Six commercially available one-piece IOLs were exposed to 2.6 mJ single-pulse Nd:YAG laser shots under standardized <i>in vitro</i> conditions. Microscopic evaluation before and after ultrasonic cleaning was performed. Raman spectroscopy was used to identify the chemical composition of any released fragments.</p><p><strong>Results: </strong>Fragments adjacent to YAG-induced pits were observed in all lens types. Raman spectroscopy confirmed that the fragments matched the chemical signature of the respective IOL material. After sonication and filtration, identical Raman spectra were obtained from fragments retained on gold-coated filters, confirming their origin from the lens surface. Fragment sizes ranged from 10-20 µm.</p><p><strong>Conclusions: </strong>This study demonstrates that solid IOL-derived fragments can be released by standard laser energy levels used in posterior capsulotomy. Although conducted <i>in vitro</i>, the findings raise concerns about the potential clinical relevance of laser-induced material release. Free-floating debris may contribute to straylight, glare, increased intraocular pressure, or inflammatory responses. Further clinical studies are warranted to systematically assess whether such microfragments lead to postoperative complications. Optimized laser parameters and precise focusing are recommended to minimize structural damage and fragment release.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Axial Length and Refraction After Gradual Versus Prompt Cessation of Atropine 0.01% Treatment for Myopia Management.","authors":"Nir Erdinest, Asaf Shemer, Shani Morad, Maya Atar-Vardi, Naomi London, David Landau, Biana Dubinsky-Pertzov, Eran Pras, Shehzad A Naroo, Yair Morad","doi":"10.1080/02713683.2025.2567593","DOIUrl":"https://doi.org/10.1080/02713683.2025.2567593","url":null,"abstract":"<p><strong>Purpose: </strong>Recent studies have demonstrated the effects of low-concentration atropine eye drops in slowing myopia progression. However, some studies have shown a rebound effect after treatment cessation. This study compares the rate of myopic progression following a rapid washout versus tapered cessation of 0.01% atropine.</p><p><strong>Methods: </strong>This retrospective study included children treated with atropine 0.01% between 2015 and 2022. After 24 months of treatment, the gradual cessation (GC) group stopped atropine by reducing usage by one day per week each month until complete discontinuation. The prompt cessation (PC) group stopped treatment immediately. Subjective refraction was measured after cycloplegia, and axial length was assessed before drop instillation to compare myopia progression between the GC and PC groups during the 12 months following treatment cessation.</p><p><strong>Results: </strong>Each group included 25 patients matched for age and spherical equivalent (SE) refractive error. The GC group had a mean age of 10.55 ± 1.19 years and the PG group 10.10 ± 1.7 years. The baseline SE refractive error averaged -4.33 ± 1.62D in GC and -4.50 ± 1.87D in PG. Mean follow-up was 12.4 ± 3.2 months (GC) and 12.2 ± 2.04 months (PG At follow up, the GC group had a mean SE refractive error progression of 0.21 ± 0.24 D and axial elongation of 0.15 ± 0.1 mm, while the PC group showed 0.43 ± 0.26 D and 0.25 ± 0.18 mm, respectively. However, linear mixed model (LMM) analysis revealed no statistically significant differences between the groups for axial length (<i>p</i> = 0.682) or SE (<i>p</i> = 0.541) change after treatment cessation.</p><p><strong>Conclusions: </strong>The findings indicate that neither gradual nor prompt discontinuation of 0.01% atropine resulted in statistically significant differences in myopia progression. These results suggest no significant differences in myopia progression after treatment cessation between the two methods and provide no evidence of a rebound effect.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-8"},"PeriodicalIF":2.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145250215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal Sealants in Pre-Clinical Development.","authors":"Jackie Tan, Leslie John Ray Foster, Frank James Lovicu, Yogambha Ramaswamy, Gurvinder Singh, Stephanie Louise Watson","doi":"10.1080/02713683.2025.2566853","DOIUrl":"https://doi.org/10.1080/02713683.2025.2566853","url":null,"abstract":"<p><strong>Purpose: </strong>To examine corneal sealants and adhesives in the pre-clinical phase of development to guide future development.</p><p><strong>Method: </strong>A systematic review of major databases from inception to 4^th March 2025.</p><p><strong>Results: </strong>Corneal sealants and adhesives can be broadly divided into biological and synthetic groups. These are further categorized by their methods of adhesion activation. This review identified the following groups: human fibrin glue, cyanoacrylates, biodendrimers, polyethylene glycol, fibrinogen, albumin, collagen, gelatin, chondroitin, hyaluronic acid, dextran, and chitosan. Burst pressures are often reported as a measure of sealing efficacy. Ideal characteristics for future development include biocompatibility, tolerate high burst pressure, on-demand activation, accelerates healing, and does no transmit infection.</p><p><strong>Conclusion: </strong>A variety of corneal sealants and adhesives are in development. To seal corneal wounds sealants and adhesive should have a range of properties to prevent leak.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1-16"},"PeriodicalIF":2.0,"publicationDate":"2025-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145238514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}