Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita
{"title":"视网膜小胶质细胞：发现糖尿病视网膜病变早期生物标志物的新机会。","authors":"Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita","doi":"10.1080/02713683.2025.2517300","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To explore the role of microglia in the pathomechanism of diabetic retinopathy (DR) from an inflammatory perspective.<b>Methods:</b> The study was conducted by searching several databases. Relevant articles were collected, summarized, and concluded.</p><p><strong>Results: </strong>Numerous studies have been conducted to identify inflammatory biomarkers for effective detection of DR; however, the results have been inconsistent. Microglia, the resident immune cells of the retinal tissue, are believed to play a potential role in the neuroinflammatory process induced by prolonged hyperglycemia in the retina. The excessive release of extracellular adenosine triphosphate (eATP) due to hyperglycemia may overstimulate P2X7R receptors, thereby activating the NLRP3 inflammasome, and leading to chronic progressive inflammation.</p><p><strong>Conclusion: </strong>Microglial activation and polarization may induce meta-inflammation, contributing to increased permeability and neovascularization, which in turn lead to proliferative diabetic retinopathy. Understanding this mechanism is essential for identifying potential biomarkers for early DR detection and developing adjunctive therapies to control disease progression.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"973-981"},"PeriodicalIF":2.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Retinal Microglia: Revealing New Opportunities for Identifying Early Biomarkers of Diabetic Retinopathy.\",\"authors\":\"Ohisa Harley, Yufilia Suci Amelia, Elsa Gustianty, Nanny N M Soetedjo, Arief S Kartasasmita\",\"doi\":\"10.1080/02713683.2025.2517300\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To explore the role of microglia in the pathomechanism of diabetic retinopathy (DR) from an inflammatory perspective.<b>Methods:</b> The study was conducted by searching several databases. Relevant articles were collected, summarized, and concluded.</p><p><strong>Results: </strong>Numerous studies have been conducted to identify inflammatory biomarkers for effective detection of DR; however, the results have been inconsistent. Microglia, the resident immune cells of the retinal tissue, are believed to play a potential role in the neuroinflammatory process induced by prolonged hyperglycemia in the retina. The excessive release of extracellular adenosine triphosphate (eATP) due to hyperglycemia may overstimulate P2X7R receptors, thereby activating the NLRP3 inflammasome, and leading to chronic progressive inflammation.</p><p><strong>Conclusion: </strong>Microglial activation and polarization may induce meta-inflammation, contributing to increased permeability and neovascularization, which in turn lead to proliferative diabetic retinopathy. Understanding this mechanism is essential for identifying potential biomarkers for early DR detection and developing adjunctive therapies to control disease progression.</p>\",\"PeriodicalId\":10782,\"journal\":{\"name\":\"Current Eye Research\",\"volume\":\" \",\"pages\":\"973-981\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Eye Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02713683.2025.2517300\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/24 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Eye Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02713683.2025.2517300","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/24 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Retinal Microglia: Revealing New Opportunities for Identifying Early Biomarkers of Diabetic Retinopathy.
Purpose: To explore the role of microglia in the pathomechanism of diabetic retinopathy (DR) from an inflammatory perspective.Methods: The study was conducted by searching several databases. Relevant articles were collected, summarized, and concluded.
Results: Numerous studies have been conducted to identify inflammatory biomarkers for effective detection of DR; however, the results have been inconsistent. Microglia, the resident immune cells of the retinal tissue, are believed to play a potential role in the neuroinflammatory process induced by prolonged hyperglycemia in the retina. The excessive release of extracellular adenosine triphosphate (eATP) due to hyperglycemia may overstimulate P2X7R receptors, thereby activating the NLRP3 inflammasome, and leading to chronic progressive inflammation.
Conclusion: Microglial activation and polarization may induce meta-inflammation, contributing to increased permeability and neovascularization, which in turn lead to proliferative diabetic retinopathy. Understanding this mechanism is essential for identifying potential biomarkers for early DR detection and developing adjunctive therapies to control disease progression.
期刊介绍：
The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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