{"title":"中国成人无视网膜病变2型糖尿病患者血清尿酸水平降低与神经节细胞内丛状层厚度变薄的纵向关系","authors":"Yiran Fan, Yuntong Li, Lingyi Li, Xinyan Wu, Yayi Yan, Ching-Kit Tsui, Kaiqun Liu, Wenyong Huang, Xiaoling Liang, Andina Hu","doi":"10.1080/02713683.2025.2517301","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To explore the associations between serum uric acid (SUA) level change and changes in the retinal neurodegenerative biomarkers in type 2 diabetes mellitus patients without retinopathy.</p><p><strong>Methods: </strong>This is a prospective observational cohort study based on the baseline and 1-year follow-up data of the Guangzhou Diabetic Eye Study. Type 2 diabetes mellitus patients without retinopathy were recruited. Thicknesses of ganglion cell inner plexiform layer (GC-IPL) and peripapillary retinal nerve fiber layer (pRNFL) were measured via swept-source optical coherence tomography. The associations between SUA level change and the thinning rates of GC-IPL and pRNFL were analyzed using multivariate linear regression analysis. Sub-group analysis based on sex was constructed.</p><p><strong>Results: </strong>A total of 1084 participants were enrolled in our study. After adjustment, both male and female patients with decreased SUA levels in higher baseline SUA level group had a significantly slower thinning rate of GC-IPL than those with non-decreased SUA levels. In higher baseline SUA level with decreased SUA level group, male patients exhibited significantly slower thinning rate of inferior GC-IPL, while female patients exhibited significantly slower thinning rate of inferior and nasal GC-IPL and inferior pRNFL, when compared to those with non-decreased SUA levels.</p><p><strong>Conclusion: </strong>Our findings prove that decreased SUA level is associated with a slower GC-IPL thinning rate in higher baseline SUA level group, suggesting that decreased SUA level could be constituted as a potential future control target to delay the neurodegeneration in type 2 diabetes mellitus patients.</p>","PeriodicalId":10782,"journal":{"name":"Current Eye Research","volume":" ","pages":"1045-1053"},"PeriodicalIF":2.0000,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Longitudinal Association of Decreased Serum Uric Acid Level with the Thinning of Ganglion Cell Inner Plexiform Layer Thickness in Chinese Adults with Type 2 Diabetes Mellitus without Retinopathy.\",\"authors\":\"Yiran Fan, Yuntong Li, Lingyi Li, Xinyan Wu, Yayi Yan, Ching-Kit Tsui, Kaiqun Liu, Wenyong Huang, Xiaoling Liang, Andina Hu\",\"doi\":\"10.1080/02713683.2025.2517301\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To explore the associations between serum uric acid (SUA) level change and changes in the retinal neurodegenerative biomarkers in type 2 diabetes mellitus patients without retinopathy.</p><p><strong>Methods: </strong>This is a prospective observational cohort study based on the baseline and 1-year follow-up data of the Guangzhou Diabetic Eye Study. Type 2 diabetes mellitus patients without retinopathy were recruited. Thicknesses of ganglion cell inner plexiform layer (GC-IPL) and peripapillary retinal nerve fiber layer (pRNFL) were measured via swept-source optical coherence tomography. The associations between SUA level change and the thinning rates of GC-IPL and pRNFL were analyzed using multivariate linear regression analysis. Sub-group analysis based on sex was constructed.</p><p><strong>Results: </strong>A total of 1084 participants were enrolled in our study. After adjustment, both male and female patients with decreased SUA levels in higher baseline SUA level group had a significantly slower thinning rate of GC-IPL than those with non-decreased SUA levels. In higher baseline SUA level with decreased SUA level group, male patients exhibited significantly slower thinning rate of inferior GC-IPL, while female patients exhibited significantly slower thinning rate of inferior and nasal GC-IPL and inferior pRNFL, when compared to those with non-decreased SUA levels.</p><p><strong>Conclusion: </strong>Our findings prove that decreased SUA level is associated with a slower GC-IPL thinning rate in higher baseline SUA level group, suggesting that decreased SUA level could be constituted as a potential future control target to delay the neurodegeneration in type 2 diabetes mellitus patients.</p>\",\"PeriodicalId\":10782,\"journal\":{\"name\":\"Current Eye Research\",\"volume\":\" \",\"pages\":\"1045-1053\"},\"PeriodicalIF\":2.0000,\"publicationDate\":\"2025-10-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Current Eye Research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/02713683.2025.2517301\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/6/19 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Eye Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/02713683.2025.2517301","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/19 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
Longitudinal Association of Decreased Serum Uric Acid Level with the Thinning of Ganglion Cell Inner Plexiform Layer Thickness in Chinese Adults with Type 2 Diabetes Mellitus without Retinopathy.
Purpose: To explore the associations between serum uric acid (SUA) level change and changes in the retinal neurodegenerative biomarkers in type 2 diabetes mellitus patients without retinopathy.
Methods: This is a prospective observational cohort study based on the baseline and 1-year follow-up data of the Guangzhou Diabetic Eye Study. Type 2 diabetes mellitus patients without retinopathy were recruited. Thicknesses of ganglion cell inner plexiform layer (GC-IPL) and peripapillary retinal nerve fiber layer (pRNFL) were measured via swept-source optical coherence tomography. The associations between SUA level change and the thinning rates of GC-IPL and pRNFL were analyzed using multivariate linear regression analysis. Sub-group analysis based on sex was constructed.
Results: A total of 1084 participants were enrolled in our study. After adjustment, both male and female patients with decreased SUA levels in higher baseline SUA level group had a significantly slower thinning rate of GC-IPL than those with non-decreased SUA levels. In higher baseline SUA level with decreased SUA level group, male patients exhibited significantly slower thinning rate of inferior GC-IPL, while female patients exhibited significantly slower thinning rate of inferior and nasal GC-IPL and inferior pRNFL, when compared to those with non-decreased SUA levels.
Conclusion: Our findings prove that decreased SUA level is associated with a slower GC-IPL thinning rate in higher baseline SUA level group, suggesting that decreased SUA level could be constituted as a potential future control target to delay the neurodegeneration in type 2 diabetes mellitus patients.
期刊介绍:
The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.