非诺贝特对糖尿病视网膜病变有保护作用。

IF 2 4区 医学 Q3 OPHTHALMOLOGY
Current Eye Research Pub Date : 2025-10-01 Epub Date: 2025-06-18 DOI:10.1080/02713683.2025.2516802
Shimei Chen, Xiaoqian Wang, Dandan Sun, Shuchang Zhang, Peiyu Liu, Xun Xu, Fang Wei, Qing Liu
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引用次数: 0

摘要

目的:本研究探讨非诺贝特对糖尿病视网膜病变视网膜健康的保护作用,重点关注其减少炎症、氧化应激和恢复自噬的能力,同时防止铁凋亡。方法:采用链脲佐菌素(STZ)诱导的糖尿病大鼠模型和高糖条件下培养的ARPE-19细胞,评估非诺贝特对氧化应激标志物、自噬相关蛋白和紧密连接完整性的影响。非诺贝特在调节炎症和预防铁下垂中的作用也被评估。结果:非诺贝特治疗可降低视网膜组织ROS生成和NADPH氧化酶活性,减轻氧化应激。此外,非诺贝特增强自噬,LC3表达增加,并维持紧密连接蛋白的表达。这些作用有助于细胞稳态的稳定,潜在地减缓疾病的进展。结论:非诺贝特通过减少炎症和氧化应激,促进自噬和抑制铁下垂,对糖尿病视网膜病变具有显著的保护作用,使其成为治疗糖尿病视网膜病变的一种有前景的治疗选择。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Fenofibrate Exerts Protective Effects in Diabetic Retinopathy.

Purpose: This study examines the protective effects of fenofibrate on retinal health in diabetic retinopathy, focusing on its ability to reduce inflammation, oxidative stress, and restore autophagy while preventing ferroptosis.

Methods: Using a streptozotocin (STZ)-induced diabetic rat model and cultured ARPE-19 cells under high glucose conditions, we assessed the impact of fenofibrate on oxidative stress markers, autophagy-related proteins, and tight junction integrity. Fenofibrate's role in modulating inflammation and preventing ferroptosis was also evaluated.

Results: Fenofibrate treatment reduced ROS production and NADPH oxidase activity, alleviating oxidative stress in retinal tissues. Additionally, fenofibrate enhanced autophagy, as indicated by increased LC3 expression, and maintained tight junction protein expression. These effects contributed to the stabilization of cellular homeostasis, potentially slowing disease progression.

Conclusion: Fenofibrate offers significant protective effects in diabetic retinopathy by reducing inflammation and oxidative stress, promoting autophagy, and inhibiting ferroptosis, making it a promising therapeutic option for managing the disease.

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来源期刊
Current Eye Research
Current Eye Research 医学-眼科学
CiteScore
4.60
自引率
0.00%
发文量
163
审稿时长
12 months
期刊介绍: The principal aim of Current Eye Research is to provide rapid publication of full papers, short communications and mini-reviews, all high quality. Current Eye Research publishes articles encompassing all the areas of eye research. Subject areas include the following: clinical research, anatomy, physiology, biophysics, biochemistry, pharmacology, developmental biology, microbiology and immunology.
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