Clinical Neurophysiology最新文献_第5页

Reply to “Revisiting the accuracy of motor evoked potential determination: The overlooked role of surface electrode montage” 回复“重新审视运动诱发电位测定的准确性：表面电极蒙太奇被忽视的作用”。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.clinph.2025.2111481

Marten Nuyts , Stefanie Verstraelen , Joana Frieske , Raf Meesen , Sybren Van Hoornweder

引用次数: 0

Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls 听觉诱发的慢振荡和纺锤波的变化与癫痫和控制儿童的记忆巩固有关。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-07 DOI: 10.1016/j.clinph.2025.2111475

Hunki Kwon , Dhinakaran M. Chinappen , Anirudh Wodeyar , Elizabeth A. Kinard , Skyler K. Goodman , Wen Shi , Bryan S. Baxter , Dara S. Manoach , Mark A. Kramer , Catherine J. Chu

{"title":"Auditory-evoked changes in slow oscillations and spindles correlate with memory consolidation in children with epilepsy and controls","authors":"Hunki Kwon , Dhinakaran M. Chinappen , Anirudh Wodeyar , Elizabeth A. Kinard , Skyler K. Goodman , Wen Shi , Bryan S. Baxter , Dara S. Manoach , Mark A. Kramer , Catherine J. Chu","doi":"10.1016/j.clinph.2025.2111475","DOIUrl":"10.1016/j.clinph.2025.2111475","url":null,"abstract":"<div><h3>Objective</h3><div>We investigated the effects of auditory stimulation during sleep on slow oscillations (SOs), SO-spindle complexes, and sleep-dependent memory consolidation in children with Rolandic Epilepsy (RE) and controls.</div></div><div><h3>Methods</h3><div>Participants completed two nap visits with auditory or sham stimulation. SOs and SO-spindle complexes rates were measured offline using validated detectors. Sleep-dependent memory consolidation was assessed using the motor sequence typing task.</div></div><div><h3>Results</h3><div>Auditory stimulation evoked SOs and SO-spindle complexes with maximal effect over frontal electrodes. Compared to sham, stimulation of background activity increased SOs (29.8 %, p < 0.001) and SO-spindle complexes (16.8 %, p < 0.001); stimulation of an ongoing SO upstate maximally evoked SOs (51.3 % increase, p < 0.001) and SO-spindle complexes (32.3 % increase, p < 0.001). Changes in frontal SO (1.9 % improvement per increase in SO/min; p < 0.001) and SO-spindle complexes (9.5 % improvement per increase in SO-spindle/min; p = 0.007) event rates due to auditory stimulation positively predicted changes in sleep-dependent memory consolidation.</div></div><div><h3>Conclusion</h3><div>Auditory stimulation reliably modulates sleep oscillations when delivered on background activity and during the upstate of SOs. As increased event rates improve memory consolidation, stimulation paradigms to increase SO and SO-spindle complex rates are required to enhance memory.</div></div><div><h3>Significance</h3><div>Auditory stimulation paradigms that increase SO and SO-spindle complex rates may enhance sleep-dependent memory consolidation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111475"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145818309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory and motor cortical hyperexcitability in patients with amyotrophic lateral sclerosis: are they related? a prospective pilot study 肌萎缩性侧索硬化症患者的感觉和运动皮质亢进性：它们之间是否相关？一项前瞻性试点研究。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2026-01-02 DOI: 10.1016/j.clinph.2025.2111485

Giovanna Squintani , Marta Di Muzio , Andrea Rasera , Fabio Paio , Giovanni Umberto Borin , Kais Humaidan , Davide Orlando , Nicola Refatti , Silvia Romito , Michele Tinazzi , Bruno Bonetti , Mario Ermani

{"title":"Sensory and motor cortical hyperexcitability in patients with amyotrophic lateral sclerosis: are they related? a prospective pilot study","authors":"Giovanna Squintani , Marta Di Muzio , Andrea Rasera , Fabio Paio , Giovanni Umberto Borin , Kais Humaidan , Davide Orlando , Nicola Refatti , Silvia Romito , Michele Tinazzi , Bruno Bonetti , Mario Ermani","doi":"10.1016/j.clinph.2025.2111485","DOIUrl":"10.1016/j.clinph.2025.2111485","url":null,"abstract":"<div><h3>Objective</h3><div>Our study evaluates sensory and motor cortical hyperexcitability as diagnostic biomarkers in ALS patients and investigates their relationship, identifying distinct or interconnected pathophysiological mechanisms in different sub-groups.</div></div><div><h3>Methods</h3><div>We examined 26 ALS patients and 18 healthy controls. Motor cortex excitability was assessed using transcranial magnetic stimulation to measure the motor evoked potential (MEP) suppression ratio. Somatosensory cortex excitability was evaluated through upper-limb somatosensory evoked potentials (SEPs) with conventional and paired-pulse techniques. Statistical analyses included parametric/non-parametric tests, correlation analyses, and χ<sup>2</sup> tests. ROC analysis was used to assess diagnostic performance. Significance threshold was p < 0.05.</div></div><div><h3>Results</h3><div>ALS patients showed a significantly reduced MEP suppression ratio (p < 0.001) with excellent discriminative power (100 % accuracy). SEP suppression ratio was significantly lower in ALS (p < 0.001), with sensitivity 76.3 %, specificity 91.7 %, and accuracy 84 %. In patients with giant SEPs, a strong inverse correlation was observed between MEP and SEP suppression ratios (r = − 0.70, p < 0.001).</div></div><div><h3>Conclusions</h3><div>MEP and SEP suppression ratio are robust biomarkers of motor cortical dysfunction in ALS patients with a highlighting cortical heterogeneity between sub-groups, suggesting cortical interconnection.</div></div><div><h3>Significance</h3><div>Alongside confirming motor and sensory cortical hyperexcitability as ALS hallmarks, this study reveals subgroup-specific patterns suggesting a compensatory interplay between sensory and motor cortex.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111485"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145951518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor evoked potentials as a side effect biomarker for deep brain stimulation 运动诱发电位作为深部脑刺激的副作用生物标志物

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-24 DOI: 10.1016/j.clinph.2025.2111499

Paola Testini , Austin Wang , Eric R. Cole , Svjetlana Miocinovic

{"title":"Motor evoked potentials as a side effect biomarker for deep brain stimulation","authors":"Paola Testini , Austin Wang , Eric R. Cole , Svjetlana Miocinovic","doi":"10.1016/j.clinph.2025.2111499","DOIUrl":"10.1016/j.clinph.2025.2111499","url":null,"abstract":"<div><h3>Objectives</h3><div>To determine if motor evoked potentials (MEP) – stimulation-induced muscle activation measured using electromyography – can serve as a biomarker of corticobulbar (CBT) and corticospinal (CST) tract activation induced by deep brain stimulation (DBS).</div></div><div><h3>Methods</h3><div>In 12 patients with Parkinson’s disease and subthalamic (n = 10) or pallidal (n = 2) DBS, contact mapping determined clinical motor side effect thresholds. For equivalent stimulation parameters (except lower frequency), EMG was recorded from cranial and arm muscles to determine the presence, peak amplitudes and latencies of MEP. Clinical side effect and MEP thresholds were compared and accuracy metrics calculated.</div></div><div><h3>Results</h3><div>The MEP amplitudes increased with stimulation intensity. Latencies were shorter for cranial muscles, which were also more likely to generate an MEP. Clinical side effect and MEP thresholds were significantly correlated (R<sup>2</sup> = 0.31; p = 0.0006), although most MEP thresholds were lower than side effect thresholds. The MEP accuracy in predicting side effects was 0.72, with a sensitivity of 0.68 and a specificity of 0.73.</div></div><div><h3>Conclusions</h3><div>MEP thresholds correlated with side effect thresholds but were often lower indicating subclinical CBT/CST activations.</div></div><div><h3>Significance</h3><div>This study characterizes motor potentials evoked by DBS and demonstrates their potential utility as an objective biomarker for motor side effect detection during DBS programming.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111499"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulation of corticospinal excitability by paired associative stimulation following stroke 脑卒中后成对联想刺激对皮质脊髓兴奋性的调节

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-06 DOI: 10.1016/j.clinph.2025.2111474

Alona Ron Levy , Iuly Treger , Uri Alyagon , Tatiana Gulevsky , Noam Ygael , Amit Hiedemann , Olga Nachliely , Orna Kohav , Judith S. Nosgorodsky , Alan Friedman , Lena Lutsky , Jechil S. Sieratzki , Abraham Zangen

引用次数: 0

Reduced neural speech tracking in adolescents with listening difficulty 听力障碍青少年的神经语言追踪功能降低

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2026-01-02 DOI: 10.1016/j.clinph.2026.2111502

Katsuaki Kojima , Chunyan Liu , Shelley Ehrlich , Harvey Dillon , Chelsea Blankenship , Lina Motlagh Zadeh , Jennifer Vannest , Lisa Hunter , Srikantan Nagarajan , David R. Moore

{"title":"Reduced neural speech tracking in adolescents with listening difficulty","authors":"Katsuaki Kojima , Chunyan Liu , Shelley Ehrlich , Harvey Dillon , Chelsea Blankenship , Lina Motlagh Zadeh , Jennifer Vannest , Lisa Hunter , Srikantan Nagarajan , David R. Moore","doi":"10.1016/j.clinph.2026.2111502","DOIUrl":"10.1016/j.clinph.2026.2111502","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate neural mechanisms underlying speech-in-speech listening in adolescents with listening difficulties (LiD).</div></div><div><h3>Methods</h3><div>Neural speech tracking (NST) was assessed using magnetoencephalography (MEG; 275 sensors) in 21 adolescents with LiD (11 females), identified by caregiver report, and 25 typically developing (TD) peers (10 females), all with normal audiograms and frequency-matched on age, sex, race, and ethnicity. Participants completed a cocktail-party task with target speech alone and with competing streams that varied in talker and spatial cues. NST was quantified using theta-band (4–8 Hz) inter-event phase coherence (IEPC) to acoustic edges.</div></div><div><h3>Results</h3><div>Adolescents with LiD showed reduced target-speech NST relative to TD peers, with comparable competitor tracking. Theta-band IEPC correlated with listening ability (partial R<sup>2</sup> = 0.10; p = 0.037). Concurrent talker and spatial cues synergistically enhanced target-speech NST, especially in TD adolescents, but not competitor streams.</div></div><div><h3>Conclusions</h3><div>LiD is characterized by impaired processing of attended speech rather than enhanced competitor processing or generalized auditory disengagement. Reduced integration of talker and spatial cues in LiD may contribute to real-world listening challenges.</div></div><div><h3>Significance</h3><div>Theta‑band NST provides a clinically relevant neural index of everyday listening and may guide interventions targeting selective attention and cue integration.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111502"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145921791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Elevated body mass index in youth is associated with neural disinhibition and internetwork functional dysconnectivity: A magnetoencephalography study 青少年身体质量指数升高与神经去抑制和网络间功能连接障碍有关：一项脑磁图研究

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-08 DOI: 10.1016/j.clinph.2025.2111476

A.C. Reichelt , E. Daskalakis , J. Cohen , K.G. Solar , M. Saberi , M. Ventresca , M. Ali , R. Zamyadi , V. Bhat , S.E. Scratch , J. Hamilton , B.T. Dunkley

{"title":"Elevated body mass index in youth is associated with neural disinhibition and internetwork functional dysconnectivity: A magnetoencephalography study","authors":"A.C. Reichelt , E. Daskalakis , J. Cohen , K.G. Solar , M. Saberi , M. Ventresca , M. Ali , R. Zamyadi , V. Bhat , S.E. Scratch , J. Hamilton , B.T. Dunkley","doi":"10.1016/j.clinph.2025.2111476","DOIUrl":"10.1016/j.clinph.2025.2111476","url":null,"abstract":"<div><h3>Objective</h3><div>The developing brain has a vulnerability to the negative impact of obesity and excessive consumption of hyperpalatable foods. Animal models suggest changes in the excitation:inhibition balance of the brain in obesogenic diets, including disinhibition and hyperexcitability, and altered connectivity between brain regions.</div></div><div><h3>Methods</h3><div>We investigated the neurophysiological effects of overweight and obesity in 32youth (8–19 years), using a naturalistic viewing protocol with magnetoencephalography (MEG). Subjects were recruited into two groups based on normalised / z-scored body mass index (zBMI), a < 1 SD group (n = 15) and ≥ 1 SD group (n = 17). We assessed spontaneous oscillatory activity and aperiodic components (spectral exponent and offset) and network functional connectivity.</div></div><div><h3>Results</h3><div>Elevated zBMI was associated with significant increases in gamma activity, as well as a reduced exponent and offset across multiple regions, which suggest changes in neural excitation and inhibition. Additionally, we observed low frequency hypoconnectivity and high frequency hyperconnectivity between multiple brain networks.</div></div><div><h3>Conclusions</h3><div>These findings underscore the neural impact of body composition on the developing brain, suggesting deleterious alterations in excitation and inhibition and brain networks linked with cognition and behaviour.</div></div><div><h3>Significance</h3><div>These alterations may contribute to the persistent behavioural rigidity and difficulties in adopting healthier eating behaviours into adulthood.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111476"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical neurophysiology in movement disorders: toward integration into systems-based practice 运动障碍的临床神经生理学：迈向系统实践的整合。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.clinph.2025.2111480

Karlo J. Lizarraga , Robert Chen

引用次数: 0

Brain connectivity predict surgical outcomes of low-grade epilepsy-associated neuroepithelial tumors 脑连通性预测低级别癫痫相关神经上皮肿瘤的手术结果

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-13 DOI: 10.1016/j.clinph.2025.2111478

Wenjie Ming , Yang Zheng , Qi Lian , Chunhong Shen , Yinxi Zhang , Zhongjin Wang , Shuang Wang , Fang Li , Zhe Zheng , Yu Qi , Junming Zhu , Hemmings Wu

{"title":"Brain connectivity predict surgical outcomes of low-grade epilepsy-associated neuroepithelial tumors","authors":"Wenjie Ming , Yang Zheng , Qi Lian , Chunhong Shen , Yinxi Zhang , Zhongjin Wang , Shuang Wang , Fang Li , Zhe Zheng , Yu Qi , Junming Zhu , Hemmings Wu","doi":"10.1016/j.clinph.2025.2111478","DOIUrl":"10.1016/j.clinph.2025.2111478","url":null,"abstract":"<div><h3>Objective</h3><div>Low-grade epilepsy-associated neuroepithelial tumors (LEATs) often cause drug-resistant epilepsy. Despite complete resection of these lesions, approximately 20% of patients continue to experience suboptimal seizure control. This study aims to investigate the predictive value of quantitative features in determining the surgical outcomes for LEAT patients.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 44 temporal LEAT patients who underwent gross-total lesionectomy. EEG features, including power spectral density (PSD) and weighted phase lag index (wPLI), were compared between patients with good (Engel I) and poor (Engel II-IV) outcomes. Significant EEG features were identified through these analyses. Domain Adversarial Neural Network (DANN) was employed to assess the predictive value of these features for surgical outcomes.</div></div><div><h3>Results</h3><div>No significant PSD differences were found, but patients with good outcomes had higher alpha-band wPLI (p = 0.008). LEATnet, predicted outcomes with an AUC of 0.81and correctly classified 8 of 11 patients in the independent validation cohort.</div></div><div><h3>Conclusions</h3><div>Alpha-band functional connectivity is a key predictor of surgical outcomes in LEAT patients.</div></div><div><h3>Significance</h3><div>EEG-based connectivity analysis may improve prognostic accuracy and aid clinical decision-making in LEAT epilepsy.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111478"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatial activation of motor evoked potentials depends on paired-pulse transcranial magnetic stimulation orientation and intensity 运动诱发电位的空间激活取决于对脉冲经颅磁刺激的方向和强度

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-10 DOI: 10.1016/j.clinph.2025.2111477

Shokoofeh Parvin , Joona Juurakko , Heikki Sinisalo , Giacinto L. Cerone , Alberto Botter , Risto J. Ilmoniemi , Harri Piitulainen , Victor H. Souza

{"title":"Spatial activation of motor evoked potentials depends on paired-pulse transcranial magnetic stimulation orientation and intensity","authors":"Shokoofeh Parvin , Joona Juurakko , Heikki Sinisalo , Giacinto L. Cerone , Alberto Botter , Risto J. Ilmoniemi , Harri Piitulainen , Victor H. Souza","doi":"10.1016/j.clinph.2025.2111477","DOIUrl":"10.1016/j.clinph.2025.2111477","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate how stimulus orientation, intensity, and interstimulus interval (ISI) in paired-pulse transcranial magnetic stimulation (TMS) influence the spatial activation of motor evoked potentials (MEPs) in forearm flexor muscles.</div></div><div><h3>Methods</h3><div>Paired-pulse paradigms were applied to the motor cortex using multi-coil TMS (mTMS) to control the stimulus parameters electronically without coil repositioning. MEP spatial activation was recorded with a high-density surface electromyography (HDsEMG) grid over the forearm muscles. Conditioning stimuli (CS) were delivered at anterior-to-medial (0°) and posterior-to-medial (90°) orientations and 70–90 % of resting motor threshold (rMT), followed by test stimuli (TS) at 0° and 110 % rMT. ISIs of 0.5 and 8 ms probed neuronal refractoriness and intracortical facilitation, respectively.</div></div><div><h3>Results</h3><div>MEPs were facilitated at 8-ms and suppressed at 0.5-ms ISI. At 0.5 ms, changing CS orientation from 0° to 90° reduced suppression. Increasing CS intensity shifted activation centroids medially in most cases. Centroids were more medial at 8 ms and more lateral at 0.5 ms.</div></div><div><h3>Conclusions</h3><div>TMS pulse orientation, intensity, and ISI systematically affect the magnitude and spatial activation of forearm muscles.</div></div><div><h3>Significance</h3><div>Our findings highlight the utility of mTMS–HDsEMG in probing neurophysiological mechanisms of corticomotor control with important diagnostic and therapeutic clinical implications.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111477"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0