Kathleen Seidel , Noah Wagner , Jonathan Wermelinger , Pablo Alvarez Abut , Mattia Branca , Sivani Sivanrupan , Philippe Schucht , Andreas Raabe
{"title":"Motor evoked potential monitoring and continuous dynamic mapping: Warning criteria during surgery on motor eloquent intra-axial brain tumors","authors":"Kathleen Seidel , Noah Wagner , Jonathan Wermelinger , Pablo Alvarez Abut , Mattia Branca , Sivani Sivanrupan , Philippe Schucht , Andreas Raabe","doi":"10.1016/j.clinph.2025.2110979","DOIUrl":"10.1016/j.clinph.2025.2110979","url":null,"abstract":"<div><h3>Objective</h3><div>We investigated the relationship between intraoperative changes of direct cortical stimulation (DCS) motor evoked potentials (MEP), lowest motor threshold (MT) reached during subcortical dynamic mapping, and the patient’s motor outcome.</div></div><div><h3>Methods</h3><div>We included data from 473 intra-axial brain tumor surgeries, 432 of which had motor outcome reported directly after surgery, at discharge and the 3-month follow-up visit. The MEP changes and MT groups were correlated with clinical parameters. Ordinal logistic regression was used to model the motor outcome with respect to the severity of the deficits based on MEP changes, MT groups and clinical parameters.</div></div><div><h3>Results</h3><div>The lower the MT, the higher was the chance of significant MEP changes. MEP changes, MT group and histopathology were predictors of deficit. The more significant the MEP changes and the lower the MT, the higher the likelihood of more severe deficits. MEP loss was associated with 184 times higher odds of causing a deficit than no MEP changes. The lowest dynamic mapping MT group (1–3 mA) was associated with 20 % of significant MEP changes and 20 % permanent deficits.</div></div><div><h3>Conclusion</h3><div>Irreversible MEP alterations, MEP loss and lower MT increase the risk of postoperative motor deficits.</div></div><div><h3>Significance</h3><div>This study validates IONM warning criteria.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110979"},"PeriodicalIF":3.6,"publicationDate":"2025-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144925529","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Meiqi Lai, Jiaxin Xiao, Jie Zhan, Wenting Li, Jianpeng Huang, Sheng Li, Nenggui Xu, Jianhua Liu
{"title":"Paired associative electroacupuncture and transcranial magnetic stimulation induced plasticity in human primary motor cortex.","authors":"Meiqi Lai, Jiaxin Xiao, Jie Zhan, Wenting Li, Jianpeng Huang, Sheng Li, Nenggui Xu, Jianhua Liu","doi":"10.1016/j.clinph.2025.2110969","DOIUrl":"10.1016/j.clinph.2025.2110969","url":null,"abstract":"<p><strong>Objective: </strong>Paired-associative stimulation (PAS) integrates transcranial magnetic stimulation (TMS) with peripheral nerve stimulation to modulate the primary motor cortex (M1) in a non-invasive manner. Numerous studies highlight its impact on M1 excitability; however, the interplay between electroacupuncture (EA) and TMS on M1 excitability remains largely unexplored. So, we designed a new PAS protocol (namely EA-PAS, an integration of EA and TMS at M1) to investigate whether the EA-PAS has the same effects as the original PAS.</p><p><strong>Methods: </strong>To confirm the physiological effects of different EA-PAS protocols, we recorded the baseline MEP amplitude in 20 healthy subjects and conducted assessments at 7-time points after the EA-PAS intervention.</p><p><strong>Results: </strong>EA-PAS<sub>25</sub> increased M1 excitability, while EA-PAS<sub>10</sub> decreased it, similar to the original PAS, with effects localized to the target muscle. No significant changes were observed with EA or TMS alone. MEPs rose at ISIs of 17 ms, 25 ms, and 35 ms, but not at 50 ms. ISIs of 10 ms and 14 ms resulted in decreased MEPs.</p><p><strong>Conclusions: </strong>This study confirmed that EA-PAS can modulate the excitability of the human M1 and identified new temporal windows, indicating potential prospects for neurological rehabilitation.</p><p><strong>Significance: </strong>This provides a preliminary clinical basis for the future application of EA-PAS in neurological rehabilitation.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110969"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144882365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Elena Hayday , Kaya Scheman , C.Price Withers , Kayla Togneri , Kareem A. Zaghloul , Jeff Stout , Antonio Ivano Triggiani , Sara K. Inati
{"title":"Magnetoencephalography distributed source modeling identifies spatiotemporal propagation patterns of interictal epileptiform discharges","authors":"Elena Hayday , Kaya Scheman , C.Price Withers , Kayla Togneri , Kareem A. Zaghloul , Jeff Stout , Antonio Ivano Triggiani , Sara K. Inati","doi":"10.1016/j.clinph.2025.2110971","DOIUrl":"10.1016/j.clinph.2025.2110971","url":null,"abstract":"<div><h3>Objective</h3><div>Magnetoencephalography (MEG) is an important adjunctive method used to localize interictal epileptiform discharges (IEDs). The equivalent current dipole (ECD) method, the current gold standard modeling approach, identifies a single point source of activity. However, IEDs propagate widely and may be better represented by distributed source modeling approaches. Here, we investigate how areas of maximal IED-related activity estimated using dynamic statistical parametric mapping (dSPM) compare to dipoles and surgical resections.</div></div><div><h3>Methods</h3><div>We analyzed resting-state MEG recordings from 38 NIH patients. We localized areas of IED-related activity along the IED rising phase and peak using spatial clustering of the top 5% of dSPM activations, comparing localizations to ECD and surgical resection areas in seizure free patients.</div></div><div><h3>Results</h3><div>We identified dominant primary activation clusters in all patients and non-primary clusters in 24/38 patients. Dipoles localized closer to primary than non-primary clusters. In 12 post-operative seizure-free patients, the primary cluster center of mass was significantly closer to the resected area than dipoles and more stable over time.</div></div><div><h3>Conclusions</h3><div>Distributed source modeling adds to our understanding of IED propagation patterns and may be useful in IED localization for epilepsy surgery planning.</div></div><div><h3>Significance</h3><div>dSPM enhances pre-surgical planning by refining IED localization, potentially improving surgical outcomes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110971"},"PeriodicalIF":3.6,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144887530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michał Błaż, Monika Ostrowska, Agnieszka Kułaga, Ewa Maludzińska, Michał Michalski
{"title":"Evaluating machine learning muscle ultrasound models on external data – is this the way to propagate forward?","authors":"Michał Błaż, Monika Ostrowska, Agnieszka Kułaga, Ewa Maludzińska, Michał Michalski","doi":"10.1016/j.clinph.2025.2110968","DOIUrl":"10.1016/j.clinph.2025.2110968","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110968"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Timing of implicit processes in aphasia: An event-related potential investigation of masked priming effects","authors":"Ashlie H. Pankonin , JoAnn P. Silkes","doi":"10.1016/j.clinph.2025.2110972","DOIUrl":"10.1016/j.clinph.2025.2110972","url":null,"abstract":"<div><h3>Objectives</h3><div>The mechanisms responsible for anomia in aphasia are not well understood. This study explores the idea that anomia could be due to changes in the timing of automatic spreading activation in the lexical system.</div></div><div><h3>Methods</h3><div>Fourteen people with aphasia (PWA) and 13 control adults completed a masked priming event-related potential (ERP) task. Target words were preceded by masked, visible, or no primes and were either immediate or delayed repetitions of those primes. Prime-target intervals were varied. Analyses primarily focused on N400 effects.</div></div><div><h3>Results</h3><div>PWA showed N400 priming effects for both immediate and delayed repetitions of masked primes, but control adults only showed priming effects for immediate repetitions of masked primes. Additionally, PWA’s priming effects were equal for delayed repetitions of masked and visible primes while the control adults showed greater priming effects for delayed repetitions of visible than masked primes.</div></div><div><h3>Conclusions</h3><div>Findings suggest PWA experience prolonged lexical activation and might be less able to integrate implicit and explicit information than control adults.</div></div><div><h3>Significance</h3><div>Improved understanding of the underlying mechanisms of language impairment in aphasia will support development of more efficient, effective aphasia treatment methods.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110972"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865051","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Motor imagery of usual walking and obstacle negotiation in early-stage Parkinson’s disease: An electroencephalographic study","authors":"Martina Putzolu , Jessica Samogin , Gaia Bonassi , Carola Cosentino , Susanna Mezzarobba , Alessandro Botta , Sara Terranova , Elisa Ravizzotti , Dante Mantini , Alessandro Vato , Elisa Pelosin , Laura Avanzino","doi":"10.1016/j.clinph.2025.2110973","DOIUrl":"10.1016/j.clinph.2025.2110973","url":null,"abstract":"<div><h3>Objective</h3><div>To assess gait imagery related activations by means of high-density electroencephalography (hdEEG) in a population of early-stage PD patients and age-matched healthy controls.</div></div><div><h3>Methods</h3><div>Fifteen patients with early-stage PD (Hohen & Yahr range: 1–2.0) and 14 age matched controls were recruited. They were asked to visually imagine walking on a straight pathway and on a straight pathway while crossing a hurdle in the middle. We registered hdEEG in the participants and analyzed α and β bands Event Related Desynchronizations (ERDs).</div></div><div><h3>Results</h3><div>PD patients showed reduced low α and high β activity and more widespread ERDs in the high α range compared to the controls. On the contrary, a similar behavior in the low β band was found between the two groups.</div></div><div><h3>Conclusions</h3><div>Findings about α activity in PD might indicate an abnormal basal ganglia-sensorimotor interaction (high α), together with attentional and executive functions deficit (low α). Low β ERD modulation is normal in patients with PD, whereas high β ERD results may indicate top-down control impairments.</div></div><div><h3>Significance</h3><div>By uncovering disparities in gait imagery related activations between the two groups, our protocol could potentially help in better understanding gait pathophysiology in the early stages of PD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110973"},"PeriodicalIF":3.6,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145198520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Laura M. Franke , Robert A. Perera , Scott R. Sponheim , James W. Hall III , Henry L. Lew , David F. Tate , William C. Walker
{"title":"Auditory event-related potentials show both auditory and non-auditory associations with chronic mild traumatic brain injury","authors":"Laura M. Franke , Robert A. Perera , Scott R. Sponheim , James W. Hall III , Henry L. Lew , David F. Tate , William C. Walker","doi":"10.1016/j.clinph.2025.2110964","DOIUrl":"10.1016/j.clinph.2025.2110964","url":null,"abstract":"<div><h3>Objective</h3><div>Auditory event-related potentials (ERP) may reflect chronic effects of repetitive mild traumatic brain injury (mild TBI), but the influence of auditory impairment on these ERP changes is unclear.</div></div><div><h3>Methods</h3><div>We compared hearing sensitivity, complex auditory processing, and auditory cortical ERPs in combat veterans (N = 270) with and without mild TBI, TBI in combat deployment setting, blast TBI, post-traumatic amnesia (PTA), loss of consciousness, and non-TBI blast exposures. Mediation analysis assessed the hearing, age, and psychological symptom-adjusted effect of number of TBI exposures on P50 and N100 amplitude and latency, and whether ERPs mediated between TBI and complex auditory processing.</div></div><div><h3>Results</h3><div>After adjustment, higher exposures to combat and blast TBI predicted larger P50 amplitudes; mild TBI with PTA was associated with longer P50 latency, which mediated speech in noise perception; combat blast exposures (non-TBI) were associated with reduced N100 amplitude.</div></div><div><h3>Conclusion</h3><div>Auditory cortical response changes observed for higher exposure to blast or combat mild TBI and blast exposures were not attributable to auditory dysfunction or current psychological distress. In contrast, mild TBI with PTA predicted auditory cortical responses with behavioral consequences for speech processing in noise.</div></div><div><h3>Significance</h3><div>Auditory P50 and N100 are promising biomarkers for both the non-auditory and auditory chronic effects of mild TBI on brain function.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110964"},"PeriodicalIF":3.6,"publicationDate":"2025-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Naoki Ikegaya , Thandar Aung , Arka N. Mallela , Jasmine L. Hect , Shobhit Singla , Alexandra Urban , James F. Castellano , Anto Ι. Bagić , Jorge A Gonzalez-Martinez
{"title":"Anatomo-Electro-Functional Investigations in Rolandic and Peri-Rolandic Epilepsies: A conceptual framework for Stereo-EEG","authors":"Naoki Ikegaya , Thandar Aung , Arka N. Mallela , Jasmine L. Hect , Shobhit Singla , Alexandra Urban , James F. Castellano , Anto Ι. Bagić , Jorge A Gonzalez-Martinez","doi":"10.1016/j.clinph.2025.2110963","DOIUrl":"10.1016/j.clinph.2025.2110963","url":null,"abstract":"<div><h3>Objective</h3><div>To develop a hypothesis-driven framework for stereoelectroencephalography (SEEG) exploration in the Rolandic and Peri-Rolandic (RPR) regions and enhance understanding of epileptogenic networks and their functional implications.</div></div><div><h3>Methods</h3><div>We reviewed 102 consecutive SEEG cases (January 2020 − February 2024). Eight patients (median age: 38 years) with suspected epileptogenic zones (EZ) within the RPR regions were included. SEEG trajectories, electrode locations, electrical stimulation tests, and surgical outcomes were analysed.</div></div><div><h3>Results</h3><div>An average of 14 SEEG electrodes (range: 11–19) were orthogonally implanted along seven key trajectories: a dorsal group targeting (1) the premotor cortex/pre-SMA (supplementary motor area), (2) precentral gyrus/SMA, (3) postcentral gyrus/central sulcus, and (4) postcentral sulcus/adjacent parietal lobe; and a ventral group targeting (5) the anterior mid-cingulate cortex, (6) posterior mid-cingulate cortex, and (7) posterior cingulate cortex. Electrical stimulation on 197 contact pairs across 31 electrodes revealed that 87 % (27/31) elicited sensorimotor responses. All SEEG explorations localized the EZ. All four subsequent resective surgeries led to seizure freedom, with minimal sensorimotor deficits over a mean 19 months follow-up (range: 9–33).</div></div><div><h3>Conclusions</h3><div>Seven key SEEG trajectories provided comprehensive RPR coverage, enabling reliable functional and EZ mapping.</div></div><div><h3>Significance</h3><div>This anatomo-electro-functional framework rationalizes SEEG explorations and supports effective resections, enhancing surgical outcomes in RPR epilepsies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110963"},"PeriodicalIF":3.6,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Raja Narendra Divakar Addanki , Sajo Thomas , Saravanan Balasundaram , Benjamin B. Lee , Katherine M. Anetakis , Jeffrey R. Balzer , Parthasarathy D. Thirumala
{"title":"Systematic review of alarm criteria and reversibility in motor-evoked potentials during intramedullary spinal cord tumor resection","authors":"Raja Narendra Divakar Addanki , Sajo Thomas , Saravanan Balasundaram , Benjamin B. Lee , Katherine M. Anetakis , Jeffrey R. Balzer , Parthasarathy D. Thirumala","doi":"10.1016/j.clinph.2025.2110966","DOIUrl":"10.1016/j.clinph.2025.2110966","url":null,"abstract":"<div><h3>Background/Objective</h3><div>Myogenic motor-evoked potentials (myogenic MEPs) and Direct waves (D-waves) are essential for monitoring motor pathways during intramedullary spinal cord tumor (IMSCT) resections. However, the diagnostic accuracy of alarm criteria and the prognostic value of reversible versus irreversible changes remain unclear. This is the first study addressing this gap.</div></div><div><h3>Methods</h3><div>Following PRISMA-DTA guidelines, this review searched PubMed, MEDLINE, and OVID (1985–2024) for studies on intraoperative myogenic MEPs and/or D-waves with postoperative motor outcomes in IMSCT resections.</div></div><div><h3>Results</h3><div>Across 25 studies (1,060 patients), log DOR for complete myogenic MEP loss predicting postoperative motor deficits was 4.18 (95% CI: 2.63–5.73), and for incomplete loss was 2.46 (95% CI: 1.74–3.18). Irreversible reductions had a log DOR of 2.513 (95% CI: 1.197–3.829), reversible 0.528 (95% CI: −0.273–1.330). D-wave monitoring used 50% threshold consistently, reversible reductions tied to 75% deficit rate.</div></div><div><h3>Conclusion/significance</h3><div>Irreversible changes in myogenic MEPs and D-waves and reversible D-wave changes increased postoperative motor deficit risk, unlike reversible myogenic MEP changes. Additionally, both incomplete and complete myogenic MEP loss predict neurological deficits; however, complete loss is a stronger predictor than incomplete loss. These findings help neurophysiologists guide the surgical team in minimizing motor pathway injury while maximizing IMSCT resections.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110966"},"PeriodicalIF":3.6,"publicationDate":"2025-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}