Clinical Neurophysiology最新文献_第5页

The seizure onset zone: More than just the "onset" zone. 癫痫发作区：不仅仅是 "发作 "区

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.clinph.2024.10.002

Katherine A Zarroli, Ramon Edmundo D Bautista

引用次数: 0

Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects 揭示发育过程中隐藏的脑电图节律：健康受试者的非周期性和周期性活动

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-28 DOI: 10.1016/j.clinph.2024.11.014

Brenda Y. Angulo-Ruiz, Elena I. Rodríguez-Martínez, Vanesa Muñoz, Carlos M. Gómez

{"title":"Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects","authors":"Brenda Y. Angulo-Ruiz, Elena I. Rodríguez-Martínez, Vanesa Muñoz, Carlos M. Gómez","doi":"10.1016/j.clinph.2024.11.014","DOIUrl":"10.1016/j.clinph.2024.11.014","url":null,"abstract":"<div><h3>Objective</h3><div>The study analyzes power spectral density (PSD) components, aperiodic (AP) and periodic (P) activity, in resting-state EEG of 240 healthy subjects from 6 to 29 years old, divided into 4 groups.</div></div><div><h3>Methods</h3><div>We calculate AP and P components using the (<em>Fitting Oscillations and One-Over-f (FOOOF))</em> plugging in EEGLAB. All PSD components were calculated from 1-45 Hz. Topography analysis, Spearman correlations, and regression analysis with age were computed for all components.</div></div><div><h3>Results</h3><div>AP and P activity show different topography across frequencies and age groups. Age-related decreases in AP exponent and offset parameters lead to reduced power, while P power decreases (1–6 Hz) and increases (10–15 Hz) with age.</div></div><div><h3>Conclusions</h3><div>We support the distinction between the AP and P components of the PSD and its possible functional changes with age. AP power is dominant in the configuration of the canonical EEG rhythms topography, although P contribution to topography is embedded in the canonical EEG topography. Some EEG canonical characteristics are similar to those of the P component, as topographies of EEG rhythms (embedded) and increases in oscillatory frequency with age.</div></div><div><h3>Significance</h3><div>We support that spectral power parameterization improves the interpretation and neurophysiological and functional accuracy of brain processes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 53-64"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study 经皮耳迷走神经刺激（taVNS）对人胆碱能神经网络的影响：一项神经生理学研究

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-26 DOI: 10.1016/j.clinph.2024.11.012

Fioravante Capone, Francesco Motolese, Alessandro Cruciani, Mariagrazia Rossi, Gabriella Musumeci, Davide Norata, Massimo Marano, Fabio Pilato, Vincenzo Di Lazzaro

{"title":"The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study","authors":"Fioravante Capone, Francesco Motolese, Alessandro Cruciani, Mariagrazia Rossi, Gabriella Musumeci, Davide Norata, Massimo Marano, Fabio Pilato, Vincenzo Di Lazzaro","doi":"10.1016/j.clinph.2024.11.012","DOIUrl":"10.1016/j.clinph.2024.11.012","url":null,"abstract":"<div><h3>Objective</h3><div>The mechanisms of actions of transcutaneous auricular vagus nerve stimulation (taVNS) are still unclear, however the activity of the cholinergic system seems to be critical for the induction of VNS-mediated plasticity. Transcranial Magnetic Stimulation (TMS) is a well-suited, non-invasive tool to investigate cortical microcircuits involving different neurotransmitters. Herein, we evaluated the effect of taVNS on short-latency afferent inhibition (SAI), a TMS paradigm specifically measuring cholinergic neurotransmission.</div></div><div><h3>Methods</h3><div>Fifteen healthy subjects participated in this randomized placebo-controlled double-blind study. Each subject underwent two different sessions of 1-hour exposure to taVNS (real and sham) separated by a minimum of 48 h. Real taVNS was administered at left external acoustic meatus, while sham stimulation was performed at left ear lobe. We evaluated SAI bilaterally over the motor cortex before and after exposure to taVNS.</div></div><div><h3>Results</h3><div>No side effects were reported by any of the participants.</div><div>Statistical analysis did not show any significant effect of taVNS on SAI.</div></div><div><h3>Conclusions</h3><div>Our study demonstrated that cholinergic circuits explored by SAI are different from circuits engaged by taVNS.</div></div><div><h3>Significance</h3><div>Since the influence of VNS on cholinergic neurotransmission has been exhaustively demonstrated in animal models, further studies are mandatory to understand the actual impact of VNS on cholinergic circuits in humans.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 47-52"},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging. 基于工作记忆事件相关振荡的机器学习可以区分临床前阿尔茨海默病和正常衰老。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-24 DOI: 10.1016/j.clinph.2024.11.013

Ke Liao, Laura E Martin, Sodiq Fakorede, William M Brooks, Jeffrey M Burns, Hannes Devos

{"title":"Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.","authors":"Ke Liao, Laura E Martin, Sodiq Fakorede, William M Brooks, Jeffrey M Burns, Hannes Devos","doi":"10.1016/j.clinph.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.11.013","url":null,"abstract":"<p><strong>Objective: </strong>To apply machine learning approaches on EEG event-related oscillations (ERO) to discriminate preclinical Alzheimer's disease (AD) from age- and sex-matched controls.</p><p><strong>Methods: </strong>Twenty-two cognitively normal preclinical AD participants with elevated amyloid and 21 cognitively normal controls without elevated amyloid completed n-back working memory tasks (n = 0, 1, 2). The absolute and relative power of ERO was extracted using the discrete wavelet transform in the delta, theta, alpha, and beta bands. Four machine learning methods were employed, and classification performance was assessed using three metrics.</p><p><strong>Results: </strong>The low-frequency bands produced higher discriminative performances compared to high-frequency bands. The 2-back task yielded the best classification capability among the three tasks. The highest area under the curve value (0.86) was achieved in the 2-back delta band nontarget condition data. The highest accuracy (80.47%) was obtained in the 2-back delta and theta bands nontarget data. The highest F1 score (0.82) was in the 2-back theta band nontarget data. The support vector machine achieved the highest performance among tested classifiers.</p><p><strong>Conclusion: </strong>This study demonstrates the promise of using machine learning on EEG ERO from working memory tasks to detect preclinical AD.</p><p><strong>Significance: </strong>EEG ERO may reveal pathophysiological differences in the earliest stage of AD when no cognitive impairments are apparent.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"1-13"},"PeriodicalIF":3.7,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive muscle silent periods in acute post-anoxic brain injury: A novel phenotype of negative myoclonus 缺氧后急性脑损伤中的重复性肌肉沉默期：阴性肌阵挛的新表型

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.010

Saeideh Salehizadeh , Suhailah Hakami , Ramesh Shrestha , Neel Fotedar

{"title":"Repetitive muscle silent periods in acute post-anoxic brain injury: A novel phenotype of negative myoclonus","authors":"Saeideh Salehizadeh , Suhailah Hakami , Ramesh Shrestha , Neel Fotedar","doi":"10.1016/j.clinph.2024.11.010","DOIUrl":"10.1016/j.clinph.2024.11.010","url":null,"abstract":"<div><h3>Objective</h3><div>To report a novel phenotype of negative myoclonus in acute post-anoxic brain injury (PABI).</div></div><div><h3>Methods</h3><div>We performed a retrospective analysis of 18-channel video-EEG and surface-EMG (sEMG) recordings of three patients with PABI. sEMG electrodes were placed on the neck, bulbar and arm muscles.</div></div><div><h3>Results</h3><div>All three patients had whole body tonic posturing with intermittent brief relaxation<strong>.</strong> In patients #1 and #2, a generalized EEG burst-suppression was present. Repetitive silent periods (SPs) were noted in the sEMG channels, time-locked to EEG bursts. The bursts preceded the SPs by 135 ms and 124 ms, respectively. The average SP duration was 910 ms and 852 ms in patients #1 and 2, respectively. Patient #3 had a generalized background suppression pattern and average SP duration of 272.5 ms. The SP recruitment pattern in patient #1 was rostro-caudal whereas patient #3 had a variable recruitment pattern.</div></div><div><h3>Conclusion</h3><div>Acute post-anoxic negative myoclonus can be detected in comatose patients with sEMG electrodes. The muscle SPs produce intermittent relaxation of the tonic posturing. The putative generator can be cortical or reticular, similar to Lance-Adams syndrome.</div></div><div><h3>Significance</h3><div>We describe a novel phenotype of negative myoclonus in acute PABI. We also describe the EEG and sEMG characteristics and the localization of the putative generator.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 4-10"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle ultrasound aids diagnosis in amyotrophic lateral sclerosis. 肌肉超声有助于肌萎缩性脊髓侧索硬化症的诊断。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.008

Andrew Hannaford, Nathan Pavey, Parvathi Menon, Mehdi A J van den Bos, Matthew C Kiernan, Neil Simon, Steve Vucic

{"title":"Muscle ultrasound aids diagnosis in amyotrophic lateral sclerosis.","authors":"Andrew Hannaford, Nathan Pavey, Parvathi Menon, Mehdi A J van den Bos, Matthew C Kiernan, Neil Simon, Steve Vucic","doi":"10.1016/j.clinph.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.11.008","url":null,"abstract":"<p><strong>Objective: </strong>There is a need for improved diagnostic tools in Amyotrophic Lateral Sclerosis (ALS). Our objective was to assess muscle ultrasound as a diagnostic tool in patients with ALS and determine a simplified screening protocol to aid implementation in clinical practice.</p><p><strong>Methods: </strong>Ultrasound of bulbar and limb muscles was prospectively performed on all patients referred to a single centre with suspected ALS. Clinical measures of disease severity and upper motor neuron impairment were also recorded. Receiver operating characteristic (ROC) curves were calculated to assess the diagnostic utility of muscle ultrasound.</p><p><strong>Results: </strong>94 patients initially suspected of ALS were recruited to this observational cohort study. Forty-four were subsequently diagnosed as ALS and 50 as disease mimics. ALS patients demonstrated a higher frequency and more generalised distribution of fasciculations compared to mimics. A simplified 5 muscle screening protocol exhibited an AUC of 0.94 (95 %CI 0.89-0.99) in discriminating ALS from mimics. The presence of ≥ 3 fasciculating muscles detected using this screening protocol was 89 % sensitive and 88 % specific for the diagnosis of ALS.</p><p><strong>Conclusions: </strong>Muscle ultrasound, screening as few as 5 muscles, has diagnostic utility in ALS.</p><p><strong>Significance: </strong>Muscle ultrasound enhances clinical diagnosis in ALS.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia DLPFC上的双侧tDCS可增强气压感受器反射灵敏度并抑制与血压相关的低痛感

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.011

Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso

{"title":"Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia","authors":"Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso","doi":"10.1016/j.clinph.2024.11.011","DOIUrl":"10.1016/j.clinph.2024.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.</div></div><div><h3>Method</h3><div>Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.</div></div><div><h3>Results</h3><div>tDCS stimulation was followed by increases in BRS, pain intensity and unpleasantness. Anxiety decreased in the Sham group, but not in the tDCS group. Positive correlations between BP and pain threshold and tolerance before stimulation were observed. These remained during stimulation in the Sham group, but not in the tDCS group. Moreover, negative associations between BRS and BP only persisted in the Sham group.</div></div><div><h3>Discussion</h3><div>The results suggest that bilateral tDCS over the DLPFC enhances BRS and modulates pain perception and BP-related mechanisms. tDCS increases pain perception by inhibiting BP-related hypoalgesia and preventing habituation of anxiety.</div></div><div><h3>Significance</h3><div>Low BRS is a powerful prognostic factor of cardiovascular disease, such that its increase via tDCS may be a new therapeutic strategy for cardiovascular health promotion.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 11-22"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology 颅内电生理学致痫区自动定位的评估指标

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-19 DOI: 10.1016/j.clinph.2024.11.007

Valentina Hrtonova , Petr Nejedly , Vojtech Travnicek , Jan Cimbalnik , Barbora Matouskova , Martin Pail , Laure Peter-Derex , Christophe Grova , Jean Gotman , Josef Halamek , Pavel Jurak , Milan Brazdil , Petr Klimes , Birgit Frauscher

{"title":"Metrics for evaluation of automatic epileptogenic zone localization in intracranial electrophysiology","authors":"Valentina Hrtonova , Petr Nejedly , Vojtech Travnicek , Jan Cimbalnik , Barbora Matouskova , Martin Pail , Laure Peter-Derex , Christophe Grova , Jean Gotman , Josef Halamek , Pavel Jurak , Milan Brazdil , Petr Klimes , Birgit Frauscher","doi":"10.1016/j.clinph.2024.11.007","DOIUrl":"10.1016/j.clinph.2024.11.007","url":null,"abstract":"<div><h3>Introduction</h3><div>Precise localization of the epileptogenic zone is critical for successful epilepsy surgery. However, imbalanced datasets in terms of epileptic vs. normal electrode contacts and a lack of standardized evaluation guidelines hinder the consistent evaluation of automatic machine learning localization models.</div></div><div><h3>Methods</h3><div>This study addresses these challenges by analyzing class imbalance in clinical datasets and evaluating common assessment metrics. Data from 139 drug-resistant epilepsy patients across two Institutions were analyzed. Metric behaviors were examined using clinical and simulated data.</div></div><div><h3>Results</h3><div>Complementary use of Area Under the Receiver Operating Characteristic (AUROC) and Area Under the Precision-Recall Curve (AUPRC) provides an optimal evaluation approach. This must be paired with an analysis of class imbalance and its impact due to significant variations found in clinical datasets.</div></div><div><h3>Conclusions</h3><div>The proposed framework offers a comprehensive and reliable method for evaluating machine learning models in epileptogenic zone localization, improving their precision and clinical relevance.</div></div><div><h3>Significance</h3><div>Adopting this framework will improve the comparability and multicenter testing of machine learning models in epileptogenic zone localization, enhancing their reliability and ultimately leading to better surgical outcomes for epilepsy patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 33-46"},"PeriodicalIF":3.7,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142720056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development 从儿童早期到晚期的脑电图非周期性动态：与多动症、认知和发育的关系。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-16 DOI: 10.1016/j.clinph.2024.11.001

Anne B. Arnett , Matthew Zimon , Sambridhi Subedi , Virginia Peisch , Erica Ferrara , Gaelle Gourdet , Carissa Mastrangelo

{"title":"EEG aperiodic dynamics from early through late childhood: Associations with ADHD, cognition, and development","authors":"Anne B. Arnett , Matthew Zimon , Sambridhi Subedi , Virginia Peisch , Erica Ferrara , Gaelle Gourdet , Carissa Mastrangelo","doi":"10.1016/j.clinph.2024.11.001","DOIUrl":"10.1016/j.clinph.2024.11.001","url":null,"abstract":"<div><h3>Background</h3><div>Aperiodic resting electroencephalography (EEG) activity is dynamic, reflecting shifting excitatory:inhibitory (E:I) balance with changing environmental conditions. We examined developmental and cognitive correlates of aperiodic and dynamic aperiodic indices in a cross-sequential cohort of early, middle, and late childhood youth with and without attention deficit hyperactivity disorder (ADHD).</div></div><div><h3>Methods</h3><div>Two-hundred eighty-five children ages 2 – 14 years provided resting EEG during high- and low-visual input conditions. Licensed clinical psychologists determined ADHD diagnosis or likelihood (in young children). Linear regressions were estimated to examine associations between aperiodic features and age, ADHD diagnosis, IQ, and experimental condition.</div></div><div><h3>Results</h3><div>From early to middle childhood, the aperiodic exponent increased linearly, indicating lower E:I, followed by a decreasing trajectory in late childhood. The aperiodic exponent was greater with high versus low visual input in young children, but this effect reversed with age. The ADHD group had a decreased aperiodic exponent, overall. Dynamic aperiodic activity, i.e. shifts in E:I balance, was associated with IQ.</div></div><div><h3>Conclusions</h3><div>The aperiodic exponent and aperiodic dynamics are proxies for age-related cortical maturation and E:I balance, and have distinct associations with ADHD symptoms and cognitive ability.</div></div><div><h3>Significance</h3><div>We provide novel evidence that dynamic aperiodic activity is a candidate marker of cortical efficiency in childhood.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 161-167"},"PeriodicalIF":3.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The sensory input, not the motor output, defines blink reflex conditioning 决定眨眼反射调节的是感觉输入，而不是运动输出

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-16 DOI: 10.1016/j.clinph.2024.11.003

Markus Kofler , Josep Valls-Solé , Michael Thurner , Elke Pucks-Faes , Viviana Versace

{"title":"The sensory input, not the motor output, defines blink reflex conditioning","authors":"Markus Kofler , Josep Valls-Solé , Michael Thurner , Elke Pucks-Faes , Viviana Versace","doi":"10.1016/j.clinph.2024.11.003","DOIUrl":"10.1016/j.clinph.2024.11.003","url":null,"abstract":"<div><h3>Objective</h3><div>Blink reflexes following supraorbital nerve (SON) stimulation are typically modulated by conditioning stimuli (CS) to the index finger (D2) (low-intensity, prepulse inhibition paradigm) or SON (same intensity, paired-pulse paradigm). We aimed to disentangle whether CS-intensity or CS-induced motor responses define blink reflex modulation.</div></div><div><h3>Methods</h3><div>In 35 subjects, test SON stimuli (8 times sensory threshold, 8 × ST) were applied either alone or following CS. In <em>experiment 1</em>, CS were delivered to D2 with low (2 × ST) or high intensity (inducing a somatosensory blink reflex). In <em>experiment 2</em>, CS were applied to SON with low (<2 × ST) or test intensity. Test blink reflex size was correlated to CS-intensity and to CS-induced motor response size. Relative strength of their influence was determined in regression analyses.</div></div><div><h3>Results</h3><div>Test blink reflex size showed higher inverse correlation to CS-intensity than to CS-induced motor response size for both CS delivered to D2 or SON. Regression analyses confirmed a significantly higher relative strength of CS-intensity than of CS-induced motor response size.</div></div><div><h3>Conclusions</h3><div>The sensory input of CS, rather than CS-induced motor output, defines subsequent blink reflex modulation.</div></div><div><h3>Significance</h3><div>This ubiquitous phenomenon calls for caution when relating the size of test responses to the size of conditioning responses particularly in paired-pulse paradigms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 168-175"},"PeriodicalIF":3.7,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142703058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0