Clinical Neurophysiology最新文献_第5页

Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer’s disease 阿尔茨海默病不同阶段丘脑核的体积和功能连接变化

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.06.018

{"title":"Volumetric and functional connectivity changes of the thalamic nuclei in different stages of Alzheimer’s disease","authors":"","doi":"10.1016/j.clinph.2024.06.018","DOIUrl":"10.1016/j.clinph.2024.06.018","url":null,"abstract":"<div><h3>Objective</h3><p>Memory processes known to be impaired in Alzheimer’s disease (AD) are maintained by a large-scale neurocognitive network with subcortical components, including the thalamus. Therefore, we aimed to examine the volumetric and functional changes of the thalamic nuclei at different scales across AD stages.</p></div><div><h3>Methods</h3><p>MRI data of patients diagnosed with 20 AD dementia (ADD), 30 amnestic mild cognitive impairment (MCI), and 30 subjective cognitive impairment (SCI) were used. Volumetric and functional connectivity analyzes were performed by dividing the thalamus into anterior, medial, posterior, lateral and intralaminar nucleus groups and their specific subnuclei.</p></div><div><h3>Results</h3><p>In the course of AD, the volume of the medial group nuclei, especially the mediodorsal medial magnocellular (MDm) nucleus, decreases. Medial group nuclei and MDm functional connectivity with frontal areas were decreased both in ADD and MCI compared to SCI group, while both of them increased their functional connectivity with visual areas in the ADD group compared to the MCI group.</p></div><div><h3>Conclusions</h3><p>Our study suggests that the medial group of the thalamus, and specifically the MDm, may be affected in AD.</p></div><div><h3>Significance</h3><p>Specific thalamic nuclei may be a critical anatomical region for investigating structural and functional changes in AD.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Significance of small sharp spikes in mesial temporal lobe epilepsy 中颞叶癫痫小尖峰的意义

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.06.016

引用次数: 0

Non-cephalic electrodes are not inactive in terms of EEG activity 非脑电极在脑电图活动方面并非不活跃

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.07.003

引用次数: 0

Premotor cortex involvement in faciobrachial dystonic seizures: A contribution from MEG-EMG study in a case of anti-LGI1 encephalitis 运动前皮层参与面肌强直性发作：对一例抗 LGI1 脑炎病例的 MEG-EMG 研究的贡献

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.07.002

引用次数: 0

Letter to the Editor: Announcement of a Call for Proposals for biomedical waveform coding 致编辑的信生物医学波形编码提案征集公告

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-02 DOI: 10.1016/j.clinph.2024.06.010

J.J. Halford, G. Campobello, B.H. Brinkmann, M. Stead, S. Rampp, J. Rémi, K.B. Nilsen, J. Dauwels, M. Galanti, B.C. Dean, S. Winkler, J.A. Ehrenberg, J. Pfaff, G.J. Sullivan

引用次数: 0

Individual-based morphological brain network changes in children with Rolandic epilepsy 罗兰氏癫痫患儿基于个体的脑形态网络变化

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-29 DOI: 10.1016/j.clinph.2024.06.013

Yu Yin , Xiaofan Qiu , Lisha Nie , Fuqin Wang , Xinyu Luo , Chunfeng Zhao , Haoyue Yu , Dan Luo , Jinhui Wang , Heng Liu

{"title":"Individual-based morphological brain network changes in children with Rolandic epilepsy","authors":"Yu Yin , Xiaofan Qiu , Lisha Nie , Fuqin Wang , Xinyu Luo , Chunfeng Zhao , Haoyue Yu , Dan Luo , Jinhui Wang , Heng Liu","doi":"10.1016/j.clinph.2024.06.013","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.06.013","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate the local cortical morphology and individual-based morphological brain networks (MBNs) changes in children with Rolandic epilepsy (RE).</p></div><div><h3>Methods</h3><p>Based on the structural MRI data of 56 children with RE and 56 healthy controls (HC), we constructed four types of individual-based MBNs using morphological indices (cortical thickness [CT], fractal dimension [FD], gyrification index [GI], and sulcal depth [SD]). The global and nodal properties of the brain networks were analyzed using graph theory. The between-group difference in local morphology and network topology was estimated, and partial correlation analysis was further analyzed.</p></div><div><h3>Results</h3><p>Compared with the HC, children with RE showed regional GI increases in the right posterior cingulate gyrus and SD increases in the right anterior cingulate gyrus and medial prefrontal cortex. Regarding the network level, RE exhibited increased characteristic path length in CT-based and FD-based networks, while decreased FD-based network node efficiency in the right inferior frontal gyrus. No significant correlation between altered morphological features and clinical variables was found in RE.</p></div><div><h3>Conclusions</h3><p>These findings indicated that children with RE have disrupted morphological brain network organization beyond local morphology changes.</p></div><div><h3>Significance</h3><p>The present study could provide more theoretical basis for exploring the neuropathological mechanisms in RE.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141582387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral median nerve stimulation and High-Frequency Oscillations unveil interhemispheric inhibition of primary sensory cortex 双侧正中神经刺激和高频振荡揭示了初级感觉皮层的半球间抑制作用

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-29 DOI: 10.1016/j.clinph.2024.06.011

{"title":"Bilateral median nerve stimulation and High-Frequency Oscillations unveil interhemispheric inhibition of primary sensory cortex","authors":"","doi":"10.1016/j.clinph.2024.06.011","DOIUrl":"10.1016/j.clinph.2024.06.011","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed at investigating the effect of median nerve stimulation on ipsilateral cortical potentials evoked by contralateral median nerve electrical stimulation.</p></div><div><h3>Methods</h3><p>We recorded somatosensory-evoked potentials (SEPs) from the left parietal cortex in 15 right-handed, healthy subjects. We administered bilateral median nerve stimulation, with the ipsilateral stimulation preceding the stimulation on the contralateral by intervals of 5, 10, 20, or 40 ms. We adjusted these intervals based on each individual’s N20 latency. As a measure of S1 excitability, the amplitude of the N20 and the area of the High Frequency Oscillation (HFO) burst were analyzed for each condition.</p></div><div><h3>Results</h3><p>The results revealed significant inhibition of N20 amplitude by ipsilateral median nerve stimulation at interstimulus intervals (ISIs) between 5 and 40 ms. Late HFO burst was suppressed at short ISIs of 5 and 10 ms, pointing to a transcallosal inhibitory effect on S1 intracortical circuits.</p></div><div><h3>Conclusions</h3><p>Findings suggest interhemispheric interaction between the primary somatosensory areas, supporting the existence of transcallosal transfer of tactile information.</p></div><div><h3>Significance</h3><p>This study provides valuable insights into the interhemispheric connections between primary sensory areas and underscore the potential role of interhemispheric interactions in somatosensory processing.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001846/pdfft?md5=a3725f5e8dacc7953f2ce46b7cd86ff1&pid=1-s2.0-S1388245724001846-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141732334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Saccades, pupil response and blink abnormalities in Huntington’s disease patients during free viewing 亨廷顿氏病患者在自由观看时的视线移动、瞳孔反应和眨眼异常

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-29 DOI: 10.1016/j.clinph.2024.06.012

{"title":"Saccades, pupil response and blink abnormalities in Huntington’s disease patients during free viewing","authors":"","doi":"10.1016/j.clinph.2024.06.012","DOIUrl":"10.1016/j.clinph.2024.06.012","url":null,"abstract":"<div><h3>Objective</h3><p>Video-based eye tracking was used to investigate saccade, pupil, and blink abnormalities among patients with Huntington’s disease (HD) who watched sequences of short videos. HD, an autosomal dominant neurodegenerative disorder resulting from a CAG mutation on chromosome 4, produces motor and cognitive impairments including slow or irregular eye movements, which have been studied using structured tasks.</p></div><div><h3>Methods</h3><p>To explore how HD affects eye movements under instruction free conditions, we assessed 22 HD patients and their age matched controls in a 10-minute video-based free viewing task.</p></div><div><h3>Results</h3><p>Patients with HD experienced a significant reduction in saccade exploration rate following video clip transitions, an increase in pupil reactions to luminance changes after clip transitions, and a significant higher blink rate throughout the task compared to the control group.</p></div><div><h3>Conclusions</h3><p>These results show that HD has a significant impact on how patients visually explore and respond to their environment under unconstrained and ecologically natural conditions.</p></div><div><h3>Significance</h3><p>Eye tracking in HD patients revealed saccadic, pupil, and blink abnormalities in early HD patients, suggestive of brain circuitry abnormalities that probably involve brain stem deficits. Further research should explore the impact of these changes on the quality of life of the patients affected by the disease.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141622779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of attentional deployment training for relieving negative emotion in individuals with subthreshold depression 注意力调配训练对缓解阈值下抑郁症患者负面情绪的影响

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-29 DOI: 10.1016/j.clinph.2024.06.009

Shuyu Li , Shuang Li , Tao Ding , Sijia Liu , Xiuyan Guo , Zhiyuan Liu

{"title":"Effects of attentional deployment training for relieving negative emotion in individuals with subthreshold depression","authors":"Shuyu Li , Shuang Li , Tao Ding , Sijia Liu , Xiuyan Guo , Zhiyuan Liu","doi":"10.1016/j.clinph.2024.06.009","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.06.009","url":null,"abstract":"<div><h3>Objective</h3><p>As a prodromal stage to major depressive disorder (MDD), subthreshold depression (StD) has a higher prevalence in the population, resulting in a greater healthcare burden. StD individuals’ current negative emotion could be moderated by attentional deployment. However, it remains unclear whether attentional deployment training can mitigate subsequent negative emotion in StD individuals.</p></div><div><h3>Methods</h3><p>Based on 160 participants, we combined decision task (Experiment 1, <em>N</em> = 69), eye-tracking (Experiment 2, <em>N</em> = 40), and EEG (Experiment 3, <em>N</em> = 51) techniques to investigate how one-week attentional deployment (gain-focus, GF) training modulated the emotional processing of negative stimulus and its underlying neural correlates in StD individuals.</p></div><div><h3>Results</h3><p>After one-week GF training, StD individuals significantly reduced the first fixation time and total fixation time on the negative part (missed opportunities) of decision outcome and showed a decrease in emotional sensitivity to missed opportunities. An increase in N1 and decrease in P3 and LPP (late positive potentials) amplitudes, as well as a decrease in alpha oscillation, were observed when StD individuals faced missed opportunities after training. Additionally, the extent of reduction in StD individuals’ emotional sensitivity to missed opportunities could be significantly predicted by the degree of decrease in alpha oscillation.</p></div><div><h3>Conclusion</h3><p>One-week attentional deployment training could modulate negative emotion in StD individuals and the degree of change in alpha oscillation might act as an objective indicator for the effectiveness of training.</p></div><div><h3>Significance</h3><p>Our study provides a convenient and effective approach to alleviate the negative emotion of StD individuals.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures 半球内背侧前运动皮层和初级运动皮层双部位 TMS 连接测量的测试-再测可靠性。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-19 DOI: 10.1016/j.clinph.2024.06.006

Robin E. Heemels , Sian Ademi , Melina Hehl

{"title":"Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures","authors":"Robin E. Heemels , Sian Ademi , Melina Hehl","doi":"10.1016/j.clinph.2024.06.006","DOIUrl":"10.1016/j.clinph.2024.06.006","url":null,"abstract":"<div><h3>Objective</h3><p>Investigating the optimal interstimulus interval (ISI) and the 24-hour test–retest reliability for intrahemispheric dorsal premotor cortex (PMd) – primary motor cortex (M1) connectivity using dual-site transcranial magnetic stimulation (dsTMS).</p></div><div><h3>Methods</h3><p>In 21 right-handed adults, left intrahemispheric PMd–M1 connectivity has been investigated with a stacked-coil dsTMS setup (conditioning stimulus: 75% of resting motor threshold; test stimulus: eliciting MEPs of 1–1.5 mV) at ISIs of 3, 5–8, and 10 ms. Additionally, M1–M1 short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were investigated to assess comparability to standard paired-pulse setups.</p></div><div><h3>Results</h3><p>Conditioning PMd led to significant inhibition of M1 output at ISIs of 3 and 5 ms, whereas 10 ms resulted in facilitation (all, p < 0.001), with a fair test–retest reliability for 3 (ICC: 0.47) and 6 ms (ICC: 0.44) ISIs. Replication of SICI (p < 0.001) and ICF (p = 0.017) was successful, with excellent test–retest reliability for SICI (ICC: 0.81).</p></div><div><h3>Conclusion</h3><p>This dsTMS setup can probe the inhibitory and facilitatory PMd–M1 connections, as well as reliably replicate SICI and ICF paradigms.</p></div><div><h3>Significance</h3><p>The stacked-coil dsTMS setup for investigating intrahemispheric PMd–M1 connectivity offers promising possibilities to better understand motor control.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0