Clinical Neurophysiology最新文献

{"title":"Investigating visuo-tactile mirror properties in borderline personality disorder: A TMS-EEG study","authors":"Agnese Zazio ,&nbsp;Cora Miranda Lanza ,&nbsp;Antonietta Stango ,&nbsp;Giacomo Guidali ,&nbsp;Eleonora Marcantoni ,&nbsp;Delia Lucarelli ,&nbsp;Serena Meloni ,&nbsp;Nadia Bolognini ,&nbsp;Roberta Rossi ,&nbsp;Marta Bortoletto","doi":"10.1016/j.clinph.2024.10.014","DOIUrl":"10.1016/j.clinph.2024.10.014","url":null,"abstract":"<div><h3>Objectives</h3><div>Patients with borderline personality disorder (pw-BPD) have decreased levels of cognitive empathy, which may be subtended by mirror-like mechanisms in the somatosensory cortices, i.e., the Tactile Mirror System (TaMS). Here, we aimed to shed light on the TaMS and empathic deficits in pw-BPD focusing on connectivity, using transcranial magnetic stimulation and electroencephalography (TMS-EEG).</div></div><div><h3>Methods</h3><div>After study preregistration, we collected self-report measures of empathic abilities, behavioral performance in a visuo-tactile spatial congruency task investigating TaMS activity, and TMS-evoked potentials (TEPs) from 20 pw-BPD and 20 healthy controls. TMS was delivered over the right primary somatosensory cortex (S1) during touch observation and real touch delivery.</div></div><div><h3>Results</h3><div>Pw-BPD reported significantly lower levels of cognitive empathy than controls and made significantly more errors in reporting the side of real touches during touch observation. Moreover, pw-BPD presented an altered connectivity pattern from S1-TEPs during touch perception and touch observation, in the last case without differences between human- and object-directed touches.</div></div><div><h3>Conclusions</h3><div>The results do not support a specific impairment of TaMS in pw-BPD, but reveal significant behavioral and connectivity alterations within the somatosensory network during touch processing.</div></div><div><h3>Significance</h3><div>The present findings temper the proposed role of the TaMS in BPD, while still highlighting the involvement of somatosensory network alterations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 139-152"},"PeriodicalIF":3.7,"publicationDate":"2024-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616306","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polygenic mutations and their brain spatial expression contribute to presurgical evaluation in patients with refractory focal epilepsy: A case report","authors":"Yingchun Xu ,&nbsp;Ping Jiang ,&nbsp;Zixian Zhou ,&nbsp;Fangzhou Liu ,&nbsp;Yingying Tang ,&nbsp;Ling Liu","doi":"10.1016/j.clinph.2024.10.015","DOIUrl":"10.1016/j.clinph.2024.10.015","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 129-130"},"PeriodicalIF":3.7,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142587456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Low-frequency EEG power and coherence differ between drug-induced parkinsonism and Parkinson’s disease","authors":"Seungbeom Seo ,&nbsp;Sunmin Kim ,&nbsp;Sung-Phil Kim ,&nbsp;Jaeho Kim ,&nbsp;Suk Yun Kang ,&nbsp;Dongil Chung","doi":"10.1016/j.clinph.2024.10.013","DOIUrl":"10.1016/j.clinph.2024.10.013","url":null,"abstract":"<div><h3>Objective</h3><div>Drug-induced parkinsonism (DIP) ranks second to Parkinson’s disease (PD) in causing parkinsonism. Despite sharing similar symptoms, DIP results from exposure to specific medications or substances, underscoring the need for accurate diagnosis. Here, we used resting-state electroencephalography (rsEEG) to investigate neural markers characterizing DIP and PD.</div></div><div><h3>Methods</h3><div>We conducted a retrospective analysis of rsEEG recordings from 18 DIP patients, 43 de novo PD patients, and 12 healthy controls (HC). After exclusions, data from 15 DIP, 41 PD, and 12 HC participants were analyzed. EEG spectral power and inter-channel coherence were compared across the groups.</div></div><div><h3>Results</h3><div>Our results demonstrated significant differences in rsEEG patterns among DIP, PD, and HC groups. DIP patients exhibited increased theta band power compared with PD patients and HC. Moreover, DIP patients showed higher delta band coherence compared with PD patients.</div></div><div><h3>Conclusion</h3><div>The current study highlights the differences in EEG spectral power and inter-channel coherence between DIP and PD patients.</div></div><div><h3>Significance</h3><div>Our results suggest that rsEEG holds promise as a valuable tool for capturing differential characteristics between DIP and PD patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 131-138"},"PeriodicalIF":3.7,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142592584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patterns of ictal surface EEG in occipital seizures: A simultaneous scalp and intracerebral recording study","authors":"Margaux Cheval ,&nbsp;Mickaël Ferrand ,&nbsp;Sophie Colnat-Coubois ,&nbsp;Olivier Aron ,&nbsp;Louise Tyvaert ,&nbsp;Laurent Koessler ,&nbsp;Louis Maillard","doi":"10.1016/j.clinph.2024.10.012","DOIUrl":"10.1016/j.clinph.2024.10.012","url":null,"abstract":"<div><h3>Objective</h3><div>To describe the ictal scalp EEG patterns of occipital seizures (OS) and their spatiotemporal correlations with intracerebral occipital ictal discharges derived from simultaneous SEEG-EEG recordings.</div></div><div><h3>Methods</h3><div>Patients with SEEG confirmed OS (14 OS from 8 patients) were selected from an epilepsy surgery center and were monitored 3–10 days using simultaneous scalp EEG and SEEG recordings.</div></div><div><h3>Results</h3><div>On scalp EEG, the most common onset patterns were background activity suppression (28.6 %) and high amplitude slow wave corresponding to intracerebral DC-shift (28.6 %) and occurred with a median delay of 0 s after intra-cerebral onset. The initial discharge involved occipital electrodes in only 50 % of the seizures (7/14) with additional basal temporal (8/14) or parietal electrodes (5/14). The onset was ipsilateral to the intra-cerebral onset zone in 71.4 % of seizures and bilateral in the remaining (28.6 %). The most common propagation pattern was either unilateral (50 %) or bilateral (50 %) and a rhythmic slow activity (66.7 %). Different OS subtypes display distinct scalp EEG patterns.</div></div><div><h3>Conclusion</h3><div>Scalp EEG accurately determines intra-cerebral seizure onset time in OS and has good lateralizing value. However, initial scalp modification does not always involves occipital electrodes and the second modification is well lateralizing in only 50 % of seizures.</div></div><div><h3>Significance</h3><div>This study describes will help clinicians to better identify OS during video EEG and better plan intra-cerebral explorations for epilepsy surgery.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 83-94"},"PeriodicalIF":3.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG-based responses of patients with disorders of consciousness and healthy controls to familiar and non-familiar emotional videos","authors":"Anny Maza ,&nbsp;Sandra Goizueta ,&nbsp;María Dolores Navarro ,&nbsp;Enrique Noé ,&nbsp;Joan Ferri ,&nbsp;Valery Naranjo ,&nbsp;Roberto Llorens","doi":"10.1016/j.clinph.2024.10.010","DOIUrl":"10.1016/j.clinph.2024.10.010","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the differences in the brain responses of healthy controls (HC) and patients with disorders of consciousness (DOC) to familiar and non-familiar audiovisual stimuli and their consistency with the clinical progress.</div></div><div><h3>Methods</h3><div>EEG responses of 19 HC and 19 patients with DOC were recorded while watching emotionally-valenced familiar and non-familiar videos. Differential entropy of the EEG recordings was used to train machine learning models aimed to distinguish brain responses to stimuli type. The consistency of brain responses with the clinical progress of the patients was also evaluated.</div></div><div><h3>Results</h3><div>Models trained using data from HC outperformed those for patients. However, the performance of the models for patients was not influenced by their clinical condition. The models were successfully trained for over 75% of participants, regardless of their clinical condition. More than 75% of patients whose CRS-R scores increased post-study displayed distinguishable brain responses to both stimuli.</div></div><div><h3>Conclusions</h3><div>Responses to emotionally-valenced stimuli enabled modelling classifiers that were sensitive to the familiarity of the stimuli, regardless of the clinical condition of the participants and were consistent with their clinical progress in most cases.</div></div><div><h3>Significance</h3><div>EEG responses are sensitive to familiarity of emotionally-valenced stimuli in HC and patients with DOC.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 104-120"},"PeriodicalIF":3.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to \"intraoperativecorticobulbar motor evoked potentials and blink reflex during skull base surgery: Significance of anesthetic Regime\".","authors":"Jiajia Liu, Xing Fan, Lirui Yang, Xiaorong Tao, Yanwen Jin, Ke Li, Jun Yang, Hui Qiao","doi":"10.1016/j.clinph.2024.10.009","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.10.009","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142581467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cervical transcutaneous spinal direct current stimulation on spinal excitability","authors":"Luca Pierantoni ,&nbsp;Fabrizio Vecchio ,&nbsp;Francesca Miraglia ,&nbsp;Cristiano Pecchioli ,&nbsp;Francesco Iodice ,&nbsp;Claudia Carrarini ,&nbsp;Mattia Pinardi ,&nbsp;Giovanni Di Pino ,&nbsp;Silvestro Micera ,&nbsp;Paolo Maria Rossini","doi":"10.1016/j.clinph.2024.10.011","DOIUrl":"10.1016/j.clinph.2024.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of transcutaneous spinal direct current stimulation (tsDCS) on spinal cord excitability using neurophysiological methods.</div></div><div><h3>Methods</h3><div>Spinal cord motoneuron excitability was assessed using various neurophysiological techniques in a sham-controlled randomized experiment, which involved delivering 2 mA tsDCS and testing four different montages. Transcranial magnetic stimulation (TMS), F-waves to supramaximal ulnar nerve stimulation and somatosensory evoked potentials to upper limb nerves stimulation were measured in the participants with the electrode configuration that yielded the greatest effect, for a total of about 18 min. 18 young volunteers were recruited.</div></div><div><h3>Results</h3><div>Among the tested ones, the most promising tsDCS montage was the one with the anode placed on the 7th cervical spinous process and the cathode on the glottis. With this configuration, a significant enhancement of motor responses in the hand muscles to TMS of the contralateral hand motor area was observed during tsDCS (<span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0.00001</mn></mrow></math></span>), reaching a plateau after 6 min. This facilitation rapidly declined within a few minutes after the tsDCS was stopped.</div></div><div><h3>Conclusion</h3><div>Results of the different techniques suggest a possible contribution to facilitatory neuromodulation of the motoneurons at the cervical spine level.</div></div><div><h3>Significance</h3><div>The occurrence of enhanced excitability after tsDCS suggests potential application in individuals with partial corticospinal fiber impairment affecting hand motor function.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 95-103"},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of CT perfusion in seizures and rhythmic and periodic patterns","authors":"Syed Ameen Ahmad ,&nbsp;Christopher Primiani ,&nbsp;Michael Porambo ,&nbsp;Tran Dang ,&nbsp;Peter W. Kaplan ,&nbsp;Vivek Yedavalli ,&nbsp;Khalil S. Husari","doi":"10.1016/j.clinph.2024.10.008","DOIUrl":"10.1016/j.clinph.2024.10.008","url":null,"abstract":"<div><h3>Objective</h3><div>CT hyper-perfusion has been reported in non-convulsive status epilepticus (NCSE), while its occurrence and relevance after single seizures or with rhythmic and periodic patterns (RPPs) that lie along the ictal-interictal continuum (IIC), remain unclear. The goal of the study is to assess the role of CT perfusion (CTP) in diagnosing patients with clinical seizures, subclinical seizures, or RPPs that lie along the IIC, to help in the clinical assessment of these entities.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed inpatients who underwent a CTP and an EEG within 6 h of each other. CTP and EEGs were blindly reviewed independent of electronic medical records.</div></div><div><h3>Results</h3><div>Out of 103 patients, 15 patients (15 %) demonstrated hyper-perfusion, 40 patients (39 %) had hypo-perfusion, while 48 patients (47 %) had normal CTP. Patients with focal CTP hyperperfusion were more likely to have clinical seizures, electrographic seizures, and/or lateralized rhythmic periodic patterns (RPPs) compared to those without CTP hyperperfusion<strong>.</strong> Focal CTP hyper-perfusion had 34 % sensitivity and 96 % specificity for identifying patients with clinical seizures, and a 40 % sensitivity and 92 % specificity for identifying patients with electrographic seizures or lateralized RPP. Although the numbers were small, none of the patients with generalized periodic discharges or generalized rhythmic delta activity had CTP hyper-perfusion.</div></div><div><h3>Conclusions</h3><div>Focal CTP hyper-perfusion has low sensitivity but high specificity for identifying patients with seizures and lateralized RPPs, and may be considered in the clinical assessment of patients where the clinical information are unclear or insufficient.</div></div><div><h3>Significance</h3><div>The presence of CTP hyper-perfusion should alert the physician to the possibility of an ictal related etiology accounting for the patient’s symptoms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 121-128"},"PeriodicalIF":3.7,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory gating and its clinical correlates in adults with chronic tic disorder and neurotypical adults","authors":"David A. Isaacs ,&nbsp;Andrew Xue ,&nbsp;Alexander C. Conley ,&nbsp;Alexandra P. Key","doi":"10.1016/j.clinph.2024.10.006","DOIUrl":"10.1016/j.clinph.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Over 80% of adults with chronic tic disorder (CTD) experience sensory over-responsivity (SOR), defined as heightened awareness of and/or behavioral reactivity to commonplace environmental stimuli. One potential mechanism underpinning SOR is sensory gating impairment. Sensory gating is the physiologic process whereby redundant stimuli are filtered out in early perceptual stages. In this study, we compared sensory gating between neurotypical and CTD adults and determined if gating indices associated with SOR.</div></div><div><h3>Methods</h3><div>Neurotypical (n = 31) and CTD adults (n = 26) completed a clinical assessment, including two SOR measures (Sensory Gating Inventory, SGI; Sensory Perception Quotient, SPQ), and an auditory gating paradigm while monitored on EEG.</div></div><div><h3>Results</h3><div>CTD adults exhibited greater SOR. Neurotypical and CTD adults did not differ in P50, N100, or P200 gating ratios. In regression analyses, N100 gating ratio was significantly associated with SGI score; the magnitude of this association was greater for neurotypical than CTD adults. No other significant associations emerged between gating ratios and SOR measures.</div></div><div><h3>Conclusion</h3><div>Findings do not support sensory gating impairment as a mechanism underpinning SOR in CTD.</div><div>The relationship between N100 gating and SOR warrants further investigation.</div></div><div><h3>Significance</h3><div>This is the first study to examine auditory gating in individuals with CTD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 72-82"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"fMRI neurofeedback for the modulation of the neural networks associated with depression","authors":"Ana Rita Barreiros ,&nbsp;Isabella B. Breukelaar ,&nbsp;Anthony W.F. Harris ,&nbsp;Mayuresh S. Korgaonkar","doi":"10.1016/j.clinph.2024.10.003","DOIUrl":"10.1016/j.clinph.2024.10.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Functional magnetic resonance imaging (fMRI) neurofeedback has emerged as a potential treatment modality for depression, but little is known about its mechanism of action. This study aims to investigate the efficacy of fMRI neurofeedback in modulating neural networks in depression.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a systematic review was conducted focusing on fMRI neurofeedback interventions in depression. A comprehensive search across multiple databases yielded 16 eligible studies for review.</div></div><div><h3>Results</h3><div>The review demonstrated that fMRI neurofeedback can modulate BOLD activity even in strategy-free protocols and within a single session, with a significant learning effect evident over sessions. Neurofeedback targeting specific regions led to changes in connectivity across broad neural networks, including the default-mode and executive control networks, with effects being region-specific. However, methodological diversity and the absence of standardized protocols in the reviewed studies highlighted the need for more uniform research approaches.</div></div><div><h3>Conclusions</h3><div>fMRI neurofeedback shows promise as a modulatory technique for depression, with the potential to induce significant changes in neural activity and connectivity of networks implicated in depression.</div></div><div><h3>Significance</h3><div>The review underscores the necessity for standardized, reproducible neurofeedback protocols with control groups to enhance research comparability and generalizability.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 34-42"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}