Clinical Neurophysiology最新文献

{"title":"Investigation of lateralized periodic discharge features associated with epileptogenesis","authors":"Eric Zhou ,&nbsp;Nicolas R. Thompson ,&nbsp;Stephen Hantus ,&nbsp;Vineet Punia","doi":"10.1016/j.clinph.2025.02.254","DOIUrl":"10.1016/j.clinph.2025.02.254","url":null,"abstract":"<div><h3>Objective</h3><div>To identify factors, especially the electrographic features, that predispose patients with lateralized periodic discharges (LPDs) to epilepsy development.</div></div><div><h3>Methods</h3><div>We included adults, without epilepsy history, who had LPDs on continuous EEG (cEEG) monitoring during hospitalization. We characterized LPDs based on American Clinical Neurophysiology Society rhythmic and periodic pattern modifiers. The outcome variable was epilepsy development as defined by clinical seizure after discharge. We used a Cox regression model to calculate adjusted hazard ratios (aHR) for epilepsy development.</div></div><div><h3>Results</h3><div>Of 174 patients, 52 (30 %) developed epilepsy during a median follow-up time of 15.0 (IQR 62.1) months. We found that an LPD-plus pattern was associated with an increased risk of epilepsy development during the follow-up period [aHR 2.67 (95 %CI 1.26–5.64)]. We also found that LPD frequency ≥ 1.5 Hz was associated with an increased risk of epilepsy development during the first year of follow-up [aHR 2.27 (95 %CI 1.02–5.05)].</div></div><div><h3>Conclusions</h3><div>Among patients with LPDs, the presence of a plus pattern and discharge frequency ≥ 1.5 Hz are both independently associated with more than two-times increased risk of epilepsy development.</div></div><div><h3>Significance</h3><div>Identification of EEG-based predictors of epileptogenesis in patients with LPDs can help early identification of patients at higher risk for future seizures and help tailor their management.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"172 ","pages":"Pages 17-21"},"PeriodicalIF":3.7,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143395213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered cortical excitability in tuberous sclerosis and the effect of mTOR inhibitors: An intracranial electrical stimulation study","authors":"Kishore Vedala ,&nbsp;Gewalin Aungaroon ,&nbsp;David Ritter ,&nbsp;Hansel M. Greiner ,&nbsp;Jeffrey R. Tenney ,&nbsp;Jesse Skoch ,&nbsp;Paul S. Horn ,&nbsp;James L. Leach ,&nbsp;Francesco T. Mangano ,&nbsp;Darcy Krueger ,&nbsp;Ravindra Arya","doi":"10.1016/j.clinph.2025.02.001","DOIUrl":"10.1016/j.clinph.2025.02.001","url":null,"abstract":"<div><h3>Objective</h3><div>We used electrical stimulation mapping (ESM) of functional responses, after-discharges (ADs), and unwanted electrical stimulation-induced seizures (EIS) to explore differences in cortical excitability in tuberous sclerosis complex (TSC) patients on mTOR inhibitors, TSC patients not on mTOR inhibitors, and drug-resistant epilepsy (DRE) of unknown etiology.</div></div><div><h3>Methods</h3><div>In 20 patients with TSC and 10 patients with DRE of unknown etiology, incidence and current thresholds of physiologic (language and motor) and pathologic (ADs, EIS) responses were analyzed using mixed effects models against disease phenotype (TSC vs unknown) and use of mTOR inhibitors.</div></div><div><h3>Results</h3><div>Patients with TSC showed a higher incidence and required a lower threshold current to elicit motor responses and ADs compared to those with DRE of unknown etiology. In TSC patients, mTOR inhibitors increased the threshold for motor responses and ADs, and decreased the incidence of face motor responses, language responses, and ADs.</div></div><div><h3>Conclusions</h3><div>TSC patients exhibit higher physiologic and pathologic cortical excitability evidenced by a higher incidence and lower current thresholds of ESM responses, which appears to be mitigated by mTOR inhibitors.</div></div><div><h3>Significance</h3><div>To our knowledge, this is the first study providing direct intracranial evidence for altered cortical excitability in TSC and the corrective effect of mTOR inhibitors.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"172 ","pages":"Pages 1-9"},"PeriodicalIF":3.7,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143385903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of semantic and phonemic variants of verbal fluency tasks: A combined MEG and fMRI study.","authors":"Alexandru Mihai Dumitrescu, Tim Coolen, Vincent Wens, Antonin Rovai, Nicola Trotta, Charline Urbain, Xavier De Tiège","doi":"10.1016/j.clinph.2025.01.015","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.01.015","url":null,"abstract":"<p><strong>Objective: </strong>The neural correlates of verbal fluency tasks (VFT) have been characterized by functional magnetic resonance imaging (fMRI). Still, the spatio-spectral neural oscillatory dynamics elicited by VFT and the differences between their semantic and phonologic variants are unsettled. We investigate, using fMRI and magnetoencephalography (MEG), the neural correlates of VFT and the differences in neural oscillatory dynamics between phonological (PFT) and semantic (SFT) fluency tasks.</p><p><strong>Methods: </strong>Thirty right-handed healthy adults underwent MEG and fMRI recordings while performing covert PFT and SFT.</p><p><strong>Results: </strong>fMRI showed different neural networks for PFT (left-dominant lexical-semantic control network) and SFT (nodes of the left-dominant semantic network). MEG showed beta-band power suppression in the left operculum in both VFT, with no difference between PFT and SFT.</p><p><strong>Conclusions: </strong>MEG and fMRI detect distinct task-induced neural activity changes during VFT. MEG findings likely reflect the neural consequences of covert word production initiated at the inferior/middle frontal gyri, as identified by fMRI.</p><p><strong>Significance: </strong>This study demonstrates the added value of combining MEG and fMRI to fully characterize VFT network dynamics. It paves the way for the use of VFT for non-invasive presurgical language mapping using a method free of neurovascular uncoupling.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alterations in temporal-spatial brain entropy in treatment-resistant depression treated with nitrous oxide: Evidence from resting-state EEG","authors":"Weizhuang Kong ,&nbsp;Zhe Sun ,&nbsp;Jing Zhu ,&nbsp;Lingjiang Li ,&nbsp;Guanru Wang ,&nbsp;Xuexiao Shao ,&nbsp;Xiaowei Li ,&nbsp;Bin Hu","doi":"10.1016/j.clinph.2025.01.014","DOIUrl":"10.1016/j.clinph.2025.01.014","url":null,"abstract":"<div><h3>Objective</h3><div>Entropy analysis can quantify the dynamic states of the brain and reflect its information processing capacity. Nitrous oxide has shown rapid antidepressant effects in treatment-resistant depression (TRD) patients, but its biomarkers are not yet established.</div></div><div><h3>Methods</h3><div>We recruited 44 TRD patients and randomly assigned them to two groups: one received a 1-hour nitrous oxide inhalation treatment, while the other received a placebo. Resting-state EEG (rs-EEG) scans were conducted at baseline and 24 h post-treatment. A novel approach based multivariate multiscale entropy (MMSE) was employed to analyze temporal-spatial brain entropy (ts-BEN) across four hierarchical brain regions.</div></div><div><h3>Results</h3><div>TRD patients exhibited significant time-dependent increases in BEN in the frontal lobe region (sensor space: time scales 5–10; source space: time scales 1–5), changes not previously observed. Temporal-spatial BEN correlated with the severity of TRD symptoms and treatment efficacy, indicating adaptive adjustments in brain resting states.</div></div><div><h3>Conclusion</h3><div>MMSE offers a novel supplementary method for rs-EEG BEN analysis, quantifying the sensitivity of ts-BEN in monitoring nitrous oxide treatment effects. Changes in frontal region ts-BEN may serve as potential biomarkers for TRD and its treatment outcomes.</div></div><div><h3>Significance</h3><div>Our findings enhance the understanding of the physiological mechanisms underlying nitrous oxide treatment for TRD, aiding in clinical diagnosis.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 182-191"},"PeriodicalIF":3.7,"publicationDate":"2025-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143373020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1924–2024: First centennial of EEG","authors":"Paolo M. Rossini ,&nbsp;Jonathan Cole ,&nbsp;Walter Paulus ,&nbsp;Ulf Ziemann ,&nbsp;Robert Chen","doi":"10.1016/j.clinph.2024.11.021","DOIUrl":"10.1016/j.clinph.2024.11.021","url":null,"abstract":"<div><div>On July 6th of 1924 Hans Berger –a German psychiatrist- first recorded electric signals from the human brainvia scalp electrodes. This date marks the beginning of Electroencephalography. In this review a representative panel of past and present Officers of the International Federation of Clinical Neurophysiology (IFCN) and of its Official Journal briefly summarizes the past, present and future of Electroencephalographic and related neurophysiological techniques’ impact and the role of the IFCN in global collaboration, education, standardization, research innovation, and clinical practice.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 132-135"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142881635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer’s disease and normal aging","authors":"Ke Liao ,&nbsp;Laura E. Martin ,&nbsp;Sodiq Fakorede ,&nbsp;William M. Brooks ,&nbsp;Jeffrey M. Burns ,&nbsp;Hannes Devos","doi":"10.1016/j.clinph.2024.11.013","DOIUrl":"10.1016/j.clinph.2024.11.013","url":null,"abstract":"<div><h3>Objective</h3><div>To apply machine learning approaches on EEG event-related oscillations (ERO) to discriminate preclinical Alzheimer’s disease (AD) from age- and sex-matched controls.</div></div><div><h3>Methods</h3><div>Twenty-two cognitively normal preclinical AD participants with elevated amyloid and 21 cognitively normal controls without elevated amyloid completed n-back working memory tasks (n = 0, 1, 2). The absolute and relative power of ERO was extracted using the discrete wavelet transform in the delta, theta, alpha, and beta bands. Four machine learning methods were employed, and classification performance was assessed using three metrics.</div></div><div><h3>Results</h3><div>The low-frequency bands produced higher discriminative performances compared to high-frequency bands. The 2-back task yielded the best classification capability among the three tasks. The highest area under the curve value (0.86) was achieved in the 2-back delta band nontarget condition data. The highest accuracy (80.47%) was obtained in the 2-back delta and theta bands nontarget data. The highest F1 score (0.82) was in the 2-back theta band nontarget data. The support vector machine achieved the highest performance among tested classifiers.</div></div><div><h3>Conclusion</h3><div>This study demonstrates the promise of using machine learning on EEG ERO from working memory tasks to detect preclinical AD.</div></div><div><h3>Significance</h3><div>EEG ERO may reveal pathophysiological differences in the earliest stage of AD when no cognitive impairments are apparent.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 1-13"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local and network changes after multichannel transcranial direct current stimulation using magnetoencephalography in patients with refractory epilepsy","authors":"Maeva Daoud ,&nbsp;Samuel Medina Villalon ,&nbsp;Ricardo Salvador ,&nbsp;Maria Fratello ,&nbsp;Khoubeib Kanzari ,&nbsp;Francesca Pizzo ,&nbsp;Giada Damiani ,&nbsp;Elodie Garnier ,&nbsp;Jean-Michel Badier ,&nbsp;Fabrice Wendling ,&nbsp;Giulio Ruffini ,&nbsp;Christian Bénar ,&nbsp;Fabrice Bartolomei","doi":"10.1016/j.clinph.2024.12.006","DOIUrl":"10.1016/j.clinph.2024.12.006","url":null,"abstract":"<div><h3>Objective</h3><div>Non-invasive neuromodulation techniques, particularly transcranial direct current stimulation (tDCS), are promising for drug-resistant epilepsy (DRE), though the mechanisms of their efficacy remain unclear. This study aims to (i) investigate tDCS neurophysiological mechanisms using a personalized multichannel protocol with magnetoencephalography (MEG) and (ii) assess post-tDCS changes in brain connectivity, correlating them with clinical outcomes.</div></div><div><h3>Methods</h3><div>Seventeen patients with focal DRE underwent three cycles of tDCS over five days, each consisting of 40-minute stimulations targeting the epileptogenic zone (EZ) identified via stereo-EEG. MEG was performed before and after sessions to assess functional connectivity (FC) and power spectral density (PSD),estimated at source level (beamforming).</div></div><div><h3>Results</h3><div>Five of fourteen patients experienced a seizure frequency reduction &gt; 50 %. Distinct PSD changes were seen across frequency bands, with reduced FC in responders and increased connectivity in non-responders (p &lt; 0.05). No significant differences were observed between EZ network and non-involved networks. Responders also had higher baseline FC, suggesting it could predict clinical response to tDCS in DRE.</div></div><div><h3>Conclusions</h3><div>Personalized multichannel tDCS induces neurophysiological changes associated with seizure reduction in DRE.</div></div><div><h3>Significance</h3><div>These results provide valuable insights into tDCS effects on epileptic brain networks, informing future clinical applications in epilepsy treatment.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 145-155"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of post-tetanic motor evoked potential as an augmentation technique under partial neuromuscular blockade during craniotomy","authors":"Ayako Oi ,&nbsp;Hironobu Hayashi ,&nbsp;Keiko Uemura ,&nbsp;Tomoshige Miyabayashi ,&nbsp;Tsunenori Takatani ,&nbsp;Ryosuke Matsuda ,&nbsp;Ryuichi Abe ,&nbsp;Ichiro Nakagawa ,&nbsp;Masahiko Kawaguchi","doi":"10.1016/j.clinph.2024.11.009","DOIUrl":"10.1016/j.clinph.2024.11.009","url":null,"abstract":"<div><h3>Objective</h3><div>In craniotomies requiring motor evoked potential (MEP) monitoring, avoiding neuromuscular blockade (NMB) is preferable, but its complete avoidance poses risks of unexpected movement. This retrospective study investigates the application of a post-tetanic MEP augmentation technique to enhance baseline recording of transcranial stimulation MEP (Tc-MEP) under partial NMB during craniotomy.</div></div><div><h3>Methods</h3><div>Twenty-six patients were included. The level of partial NMB was maintained at a train-of-four ratio of approximately 40 %. Monophasic constant-current stimulation was applied on the craniotomy side with + 20 % of the threshold intensity. Post-tetanic Tc-MEP, involving tetanic stimulation of the median nerve 1 s before transcranial stimulation, was performed on patients who failed to record using conventional baseline recording.</div></div><div><h3>Results</h3><div>The post-tetanic Tc-MEP technique successfully improved the success rate of baseline recording from 61.5 % to 100 %. Application of post-tetanic Tc-MEP significantly increased amplitudes in both the upper (p = 0.04) and lower limbs (p &lt; 0.01) compared to before post-tetanic Tc-MEP. No patients had unexpected movements.</div></div><div><h3>Conclusions</h3><div>This study indicates that post-tetanic Tc-MEP enhanced the success rate of baseline recording during craniotomy under partial NMB.</div></div><div><h3>Significance</h3><div>The combination of partial NMB and post-tetanic Tc-MEP could be a useful regimen for craniotomy with MEP monitoring, addressing both safety concerns and successful baseline recording.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 22-28"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Muscle ultrasound aids diagnosis in amyotrophic lateral sclerosis","authors":"Andrew Hannaford ,&nbsp;Nathan Pavey ,&nbsp;Parvathi Menon ,&nbsp;Mehdi A.J. van den Bos ,&nbsp;Matthew C Kiernan ,&nbsp;Neil Simon ,&nbsp;Steve Vucic","doi":"10.1016/j.clinph.2024.11.008","DOIUrl":"10.1016/j.clinph.2024.11.008","url":null,"abstract":"<div><h3>Objective</h3><div>There is a need for improved diagnostic tools in Amyotrophic Lateral Sclerosis (ALS). Our objective was to assess muscle ultrasound as a diagnostic tool in patients with ALS and determine a simplified screening protocol to aid implementation in clinical practice.</div></div><div><h3>Methods</h3><div>Ultrasound of bulbar and limb muscles was prospectively performed on all patients referred to a single centre with suspected ALS. Clinical measures of disease severity and upper motor neuron impairment were also recorded. Receiver operating characteristic (ROC) curves were calculated to assess the diagnostic utility of muscle ultrasound.</div></div><div><h3>Results</h3><div>94 patients initially suspected of ALS were recruited to this observational cohort study. Forty-four were subsequently diagnosed as ALS and 50 as disease mimics. ALS patients demonstrated a higher frequency and more generalised distribution of fasciculations compared to mimics. A simplified 5 muscle screening protocol exhibited an AUC of 0.94 (95 %CI 0.89–0.99) in discriminating ALS from mimics. The presence of ≥ 3 fasciculating muscles detected using this screening protocol was 89 % sensitive and 88 % specific for the diagnosis of ALS.</div></div><div><h3>Conclusions</h3><div>Muscle ultrasound, screening as few as 5 muscles, has diagnostic utility in ALS.</div></div><div><h3>Significance</h3><div>Muscle ultrasound enhances clinical diagnosis in ALS.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 234-243"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neurophysiological assessment of cortical motor function: A direct comparison of methodologies","authors":"Steve Vucic ,&nbsp;Nathan Pavey ,&nbsp;Parvathi Menon ,&nbsp;Michael Babayev ,&nbsp;Anna Maslyukova ,&nbsp;Anatoliy Muraviev ,&nbsp;Matthew C. Kiernan","doi":"10.1016/j.clinph.2024.12.001","DOIUrl":"10.1016/j.clinph.2024.12.001","url":null,"abstract":"<div><h3>Objective</h3><div>Assessment of cortical function with threshold tracking transcranial magnetic stimulation (TT-TMS) has developed as a biomarker to inform disease pathophysiology, particularly in neurodegenerative disease and dementia. At present, a fully integrated testing system does not exist. To advance clinical utility, and to streamline software design to integrate with diagnostic approaches in an outpatient setting, the present series of studies assessed the effects of altering diagnostic paradigms to measure interstimulus interval (ISI) including serial ascending [T-SICIs] and parallel [T-SICIp] methodologies as measures of cortical motor function (the MagXite software).</div></div><div><h3>Methods</h3><div>Cortical excitability was assessed in 30 healthy controls with a figure-of-eight coil, using an integrated approach compared to previously established experimental paradigms. Motor evoked responses were recorded over the contralateral abductor pollicis brevis muscle. Short interval intracortical inhibition (SICI) was recorded with each testing paradigm and validated in a healthy control cohort.</div></div><div><h3>Results</h3><div>The integrated system determined a robust measure of T-SICIs between ISI 1-to-7 ms (16.6 ± 2.2 %) that was comparable to previously established testing paradigms (P = 0.34), but greater than T-SICIp (MagXite 10.7 ± 1.5 %, P = 0.016; Sydney TT-TMS 8.7 ± 1.4 %, P = 0.03). SICI peaks at ISI 1 and 2.5-to-3 ms were evident with both protocols. Significant correlations were evident between mean T-SICIs-_MagXite and T-SICIp-_MagXite (R = 0.599, P &lt; 0.001).</div></div><div><h3>Conclusion</h3><div>The present series validates a fully integrated motor cortical functional assessment to provide reproducible measures of SICI, with data obtained for intracortical inhibition that is more prominent when assessed using the method of serial ascending order.</div></div><div><h3>Significance</h3><div>An integrated system for transcranial magnetic stimulation of the human motor system has been validated for clinical practice, suitable for the assessment of cortical function in neurological disease in an outpatient clinic setting.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 14-21"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794472","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}