Clinical Neurophysiology最新文献

Letter to the Editor: Ephatic transmission impairs trigemino-cervical reflex monitoring during microvascular decompression surgery for hemifacial spasm

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-09 DOI: 10.1016/j.clinph.2025.03.039

Denise Lima Medeiros de Melo , Dayanne Rodrigues da Cunha Alves Bento Oliveira , Denise Spinola Pinheiro , Gilberto Mastrocola Manzano

引用次数: 0

Estimating sensor-space EEG connectivity PART 1: Identifying best performing methods for functional connectivity in simulated data

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-08 DOI: 10.1016/j.clinph.2025.03.043

Aleksandra Miljevic , Oscar W. Murphy , Paul B. Fitzgerald , Neil W. Bailey

{"title":"Estimating sensor-space EEG connectivity PART 1: Identifying best performing methods for functional connectivity in simulated data","authors":"Aleksandra Miljevic , Oscar W. Murphy , Paul B. Fitzgerald , Neil W. Bailey","doi":"10.1016/j.clinph.2025.03.043","DOIUrl":"10.1016/j.clinph.2025.03.043","url":null,"abstract":"<div><h3>Objective</h3><div>Functional brain connectivity (FC) can be estimated using electroencephalography (EEG). However, there is considerable variability across studies in the FC measures used and in data (pre-)processing methods, leading to difficulties comparing and amalgamating results between studies. Thus, standardisation of EEG (pre-)processing for the measurement and reporting of FC is needed.We aimed to assess differences in FC estimates produced by different settings across multiple EEG pre-processing steps, (including re-referencing and epoching) to validate a reliable methodological pipeline for assessing EEG-FC in simulated EEG data.</div></div><div><h3>Methods</h3><div>We simulated EEG-FC data where the ‘ground truth’ of the connections is known and compared estimates of FC from this ground truth data across multiple FC measures and variations in multiple pre-processing steps.</div></div><div><h3>Results</h3><div>Our results indicated that pre-processing steps that included segmenting the data into 40 or more epochs that were 6 s or more in length provided the most accurate estimation of the simulated FC. With regards to the data re-referencing, the Reference Electrode Standardization Technique or the common average re-referencing appeared best when used in conjunction with imaginary coherence and weighted phase lag index metrics. However, the magnitude-squared coherence FC measure performed best with the Current Source Density reference free techniques.</div></div><div><h3>Conclusions & Significance</h3><div>Our paper provides an evidence-base for the influence of referencing, epoch length and number, controls for volume conduction, and different FC metrics on EEG-FC measurement. Using this evidence, we present an initial and promising account of the best performing (pre-)processing choices for robust EEG-FC assessment.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 73-83"},"PeriodicalIF":3.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estimating sensor-space EEG connectivity PART 2: Identifying optimal artifact reduction techniques for functional connectivity in real data

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-08 DOI: 10.1016/j.clinph.2025.03.042

Aleksandra Miljevic , Oscar W. Murphy , Paul B. Fitzgerald , Neil W. Bailey

{"title":"Estimating sensor-space EEG connectivity PART 2: Identifying optimal artifact reduction techniques for functional connectivity in real data","authors":"Aleksandra Miljevic , Oscar W. Murphy , Paul B. Fitzgerald , Neil W. Bailey","doi":"10.1016/j.clinph.2025.03.042","DOIUrl":"10.1016/j.clinph.2025.03.042","url":null,"abstract":"<div><h3>Objectives</h3><div>Electroencephalography (EEG) can be used to assess functional brain connectivity (FC). However, there is considerable variability in the methods used for FC measurement across different studies, which may contribute to heterogeneity in research outcomes. We aimed to assess how different EEG pre-processing steps impact EEG-FC measurement when applied to real EEG data.</div></div><div><h3>Methods</h3><div>Using the <span><span>BrainClinics.com</span><svg><path></path></svg></span> open-source EEG data repository we investigated how different pre-processing steps impacted the ability to detect age-related differences in alpha band FC and the test–retest reliability of FC measures. The pre-processing steps tested included artifact reduction techniques (Independent Component Analysis (ICA), wavelet-enhanced ICA (wICA), and Multi-channel Wiener Filters (MWF)), different epoch lengths (epochs that were 2 s versus 6 s in length), and different re-referencing montages (the common average reference (CAR) versus current source density (CSD) re-referencing). We also assessed different FC metrics including imaginary coherence (iCOH), real magnitude squared coherence (rMSC), and weighted phase lag index (wPLI) metrics.</div></div><div><h3>Results</h3><div>The best performing pipeline at detecting age-related differences in alpha FC and providing high test–retest reliability included artifact reduction by ICA or wICA, data re-referenced using the CSD method, and FC measured by rMSC.</div></div><div><h3>Conclusion & significance</h3><div>This paper presents evidence for an EEG pre-processing pipeline that provides good detection of meaningful effects and high test–retest reliability for sensor space EEG alpha frequency FC.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 61-72"},"PeriodicalIF":3.7,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sawtooth delta of the thalamus: A physiological variant and the intracranial generator of rapid-eye movement sleep sawtooth waves

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-07 DOI: 10.1016/j.clinph.2025.03.040

Vasileios Kokkinos , Helweh Hussein , Joshua Rosenow , Stephan U. Schuele

{"title":"Sawtooth delta of the thalamus: A physiological variant and the intracranial generator of rapid-eye movement sleep sawtooth waves","authors":"Vasileios Kokkinos , Helweh Hussein , Joshua Rosenow , Stephan U. Schuele","doi":"10.1016/j.clinph.2025.03.040","DOIUrl":"10.1016/j.clinph.2025.03.040","url":null,"abstract":"<div><h3>Objective</h3><div>To describe slow wave activity in the thalamic centro-median nucleus (CMN) region during rapid eye-movement (REM) sleep and its relation to the scalp EEG sawtooth waves.</div></div><div><h3>Methods</h3><div>Five (5) patients undergoing stereo-electroencephalography were implanted in the CMN. Sleep was scored using the concurrent scalp EEG, eye-movement artifacts in Fp1, Fp2, F7, and F8, and chin EMG.</div></div><div><h3>Results</h3><div>In the CMN region, blocks of successive delta waves assuming a sawtooth morphology were observed, presenting with high specificity for REM (p<sub>WvsREM</sub> < 0.00001; p<sub>NREMvsREM</sub> < 0.00001). Sawtooth delta of the thalamus (SDT) presented with discrete high-delta biphasic (∼2.5–4 Hz) and low-delta triphasic (∼1–2.5 Hz) morphologies; the former maximized in CMN space, while the latter in the adjacent ventro-lateral nucleus (VLN). The biphasic SDT’s negative peaks were time-locked to the positive peaks of REM sawtooth waves on scalp (mean lag.</div><div>16.7 ± 5.6 msec). SDT was not specific to tonic or phasic REM (p = 0.179), and was not associated with REM intracranial interictal or ictal activity.</div></div><div><h3>Conclusions</h3><div>SDT is a physiological variant, specific to REM sleep, manifesting with two morphologically distinct subtypes, one of them generating REM sawtooth waves on scalp.</div></div><div><h3>Significance</h3><div>Discriminating between this physiological variant and actual ictal neurophysiological signatures is imperative for efficient therapeutic CMN neurostimulation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 84-95"},"PeriodicalIF":3.7,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143821287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-06 DOI: 10.1016/j.clinph.2025.03.045

Marija Pranjić , Virginia Peisch , Gaelle Gourdet , Matthew Zimon , Anne B. Arnett

{"title":"Movement-related cortical potentials underlying motor preparation and execution in children with attention-deficit/hyperactivity disorder","authors":"Marija Pranjić , Virginia Peisch , Gaelle Gourdet , Matthew Zimon , Anne B. Arnett","doi":"10.1016/j.clinph.2025.03.045","DOIUrl":"10.1016/j.clinph.2025.03.045","url":null,"abstract":"<div><h3>Objective</h3><div>Motor control difficulties are highly common in Attention-Deficit/Hyperactivity Disorder (ADHD), yet the etiology of this comorbidity remains unclear. We examined (1) whether children with ADHD have atypical movement-related cortical potentials (MRCPs) during movement preparation and/or execution compared to typically developing (TD) children, and (2) whether MRCPs associated with visual-motor performance and ADHD symptoms overlap.</div></div><div><h3>Methods</h3><div>MRCPs and visual-motor integration (VMI) were measured among 66 right-handed children with ADHD and 30 TD children (ages 7–11 years). Caregivers reported on ADHD symptoms. MRCPs were extracted over fronto-central scalp regions during two ERP tasks requiring button presses.</div></div><div><h3>Results</h3><div>Children with ADHD had lower accuracy on MRCP tasks and reduced VMI scores, compared to TDs. ADHD diagnosis was associated with attenuated <em>correct</em> trial MRCP amplitudes at a fronto-midline electrode during movement preparation, but not execution. ADHD symptom severity and reduced <em>error</em> trial MRCP amplitudes each explained unique variance in VMI performance.</div></div><div><h3>Conclusions</h3><div>Pediatric ADHD is associated with atypical cortical activity during movement preparation, but not execution. VMI performance and ADHD diagnosis were associated with distinct motor cortical processes, providing support for the separate etiology hypothesis.</div></div><div><h3>Significance</h3><div>Motor difficulties in children with ADHD may require an intervention approach that is distinct from the treatment of core ADHD symptoms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 50-58"},"PeriodicalIF":3.7,"publicationDate":"2025-04-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143807256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AB-156. Differences of hematology parameters in children with febrile seizure types

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-01 DOI: 10.1016/j.clinph.2025.02.044

Ryan Putra , Yeni Kusumawati , Fauzi Effendi , Ita Mustopa

引用次数: 0

AB-158. Quantitative evaluation of factors contributing to the results of 3Hz RNS test on ALS patients

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-01 DOI: 10.1016/j.clinph.2025.02.045

Jinghong Zhang, Fei Yang, Mao Li, Yahui Zhu, Xusheng Huang

引用次数: 0

AB-297. High beta pallidal desynchronization during voluntary movement in dystonia and Parkinson’s disease

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-01 DOI: 10.1016/j.clinph.2025.02.101

Veronika Filyushkina , Svetlana Usova , Anna Gamaleya , Alexey Tomskiy , Alexey Sedov

引用次数: 0

AB-270. Sleep sigma power and spindles profiling in pediatric Autism Spectrum Disorder

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-01 DOI: 10.1016/j.clinph.2025.02.090

Sasha D’Ambrosio , Daniele Gualandris , Davide Caputo , Francesco Donati , Ahmad Mayeli , Fabio Ferrarelli , Renata Del Giudice , Armando D’Agostino , Maria Paola Canevini

引用次数: 0

AB-132. Neural source reconstruction using ultra-high density EEG and vibrotactile stimulation

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-04-01 DOI: 10.1016/j.clinph.2025.02.033

Leonhard Schreiner , Christy Li

引用次数: 0