Clinical Neurophysiology最新文献

Abnormal nonlinear Brain-Heart interactions in major depressive disorder: Evidence from Resting-State EEG and ECG 重性抑郁症的异常非线性脑-心相互作用：静息状态脑电图和心电图的证据

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-27 DOI: 10.1016/j.clinph.2025.2111371

Han Zhang , Hongliang Zhou , Qian Liao , Xinyi Wang , Cong Pei , Junling Sheng , Zhijian Yao , Qing Lu

{"title":"Abnormal nonlinear Brain-Heart interactions in major depressive disorder: Evidence from Resting-State EEG and ECG","authors":"Han Zhang , Hongliang Zhou , Qian Liao , Xinyi Wang , Cong Pei , Junling Sheng , Zhijian Yao , Qing Lu","doi":"10.1016/j.clinph.2025.2111371","DOIUrl":"10.1016/j.clinph.2025.2111371","url":null,"abstract":"<div><h3>Objective</h3><div>Major depressive disorder (MDD) disrupts the interactions between the brain and heart, yet the underlying mechanisms remain poorly understood. This study aims to investigate the abnormal nonlinear brain–heart interactions in MDD from a nonlinear perspective.</div></div><div><h3>Method</h3><div>Resting-state EEG and ECG signals were recorded from 38 MDD patients and 32 healthy controls. Convergent cross mapping (CCM) was used to explore the bidirectional interactions between EEG oscillations and heart rate variability (HRV). Pearson correlation assessed the relationship between abnormal brain–heart interactions and clinical symptoms. Feature ranking identified the key brain–heart interactions features for MDD.</div></div><div><h3>Results</h3><div>MDD patients showed significantly attenuated heart-to-brain interactions in the high δ and θ bands, indicating a disrupted bottom-up interoceptive information flow. Heart-to-high δ interaction negatively correlated with the HAMD-24 score (<em>r</em> = -0.500, <em>p</em> = 0.008), linking impaired heart-to-brain interactions with depression severity. HRV control analysis confirmed that the impairment in heart-to-high δ interactions was associated to depression severity, not to autonomic dysfunction. Feature ranking emphasized the critical role of heart-to-brain interactions in low-frequency EEG oscillations.</div></div><div><h3>Conclusion</h3><div>Abnormal heart-to-brain interactions play a substantial role in the pathophysiology of depression.</div></div><div><h3>Significance</h3><div>These findings highlight the importance of brain–heart dynamics in MDD and provide new insights into its underlying physiological mechanisms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"180 ","pages":"Article 2111371"},"PeriodicalIF":3.6,"publicationDate":"2025-09-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145219250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gold standard for estimation of propagation velocity from axono- or cortico-cortical evoked potentials? A case study 轴突诱发电位或皮质-皮质诱发电位传播速度估计的金标准？案例研究

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-22 DOI: 10.1016/j.clinph.2025.2111370

Clotilde Turpin , Olivier Rossel , Félix Schlosser-Perrin , Mathilde Carrière , Riki Matsumoto , Emmanuel Mandonnet , Hugues Duffau , Sam Ng , François Bonnetblanc

引用次数: 0

Altered cortical plasticity but preserved cholinergic transmission in HIV-associated dementia: A TMS study 一项经颅磁刺激研究：艾滋病毒相关痴呆患者大脑皮层可塑性改变但胆碱能传递保留

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-21 DOI: 10.1016/j.clinph.2025.2111369

Raffaele Nardone , Luca Sebastianelli , Patrick B. Langthaler , Kerstin Schwenker , Eugen Trinka , Viviana Versace

{"title":"Altered cortical plasticity but preserved cholinergic transmission in HIV-associated dementia: A TMS study","authors":"Raffaele Nardone , Luca Sebastianelli , Patrick B. Langthaler , Kerstin Schwenker , Eugen Trinka , Viviana Versace","doi":"10.1016/j.clinph.2025.2111369","DOIUrl":"10.1016/j.clinph.2025.2111369","url":null,"abstract":"<div><h3>Objective</h3><div>We used transcranial magnetic stimulation (TMS) to examine whether short-latency afferent inhibition (SAI)—a marker of cholinergic transmission—and long-term potentiation (LTP)-like cortical plasticity via paired associative stimulation (PAS25) are affected in patients with HIV-associated dementia (HAD).</div></div><div><h3>Methods</h3><div>Seventeen HAD and 17 age-matched healthy controls (HCs) underwent SAI assessment; 15 subjects per group also completed PAS25. Resting motor threshold (RMT) and motor evoked potentials (MEPs) were recorded. SAI was measured as the ratio of conditioned to unconditioned MEPs, using peripheral stimulation followed by motor cortex TMS. PAS25 consisted of 180 paired peripheral–cortical stimuli at 0.2 Hz; MEPs were recorded at baseline, 0, 15, and 30 min (T0, T15, T30) post-intervention.</div></div><div><h3>Results</h3><div>RMT and SAI did not differ between HAD and HCs (RMT: 54.0 ± 7.8 vs. 50.7 ± 6.1; SAI: 46.9 ± 8.6 % vs. 44.9 ± 5.3 %). PAS25 significantly increased MEPs amplitude in HCs at all timepoints (RTEs: T0 = 0.76, T15 = 0.87, T30 = 0.80), but not in HAD (T0 = 0.31, T15 = 0.29, T30 = 0.26).</div></div><div><h3>Conclusions</h3><div>In HAD, cholinergic activity is preserved in motor cortex, while glutamate-dependent LTP-like plasticity is impaired.</div></div><div><h3>Significance</h3><div>SAI and PAS25 are complementary neurophysiological tools distinguishing HAD from Alzheimer’s disease.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111369"},"PeriodicalIF":3.6,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Periodic lateralized epileptiform discharges, lateralized periodic discharges, and beyond: Reuniting terminology with clinical meaning 周期性癫痫样侧化放电，侧化周期性放电及其他：术语与临床意义的重新统一

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-20 DOI: 10.1016/j.clinph.2025.2111368

Vineet Punia

引用次数: 0

Tongue shear wave elastography for bulbar dysfunction in amyotrophic lateral sclerosis 舌横波弹性成像诊断肌萎缩性侧索硬化症患者的球功能障碍

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-20 DOI: 10.1016/j.clinph.2025.2111367

Kaori Yanagawa , Makiko Ike , Azusa Aoyama , Takeshi Yokoo , Shuji Terai , Takafumi Hayashi , Osamu Onodera

{"title":"Tongue shear wave elastography for bulbar dysfunction in amyotrophic lateral sclerosis","authors":"Kaori Yanagawa , Makiko Ike , Azusa Aoyama , Takeshi Yokoo , Shuji Terai , Takafumi Hayashi , Osamu Onodera","doi":"10.1016/j.clinph.2025.2111367","DOIUrl":"10.1016/j.clinph.2025.2111367","url":null,"abstract":"<div><h3>Objective</h3><div>Amyotrophic lateral sclerosis (ALS) often manifests with tongue involvement, leading to dysarthria and dysphagia. While current diagnostic methods are invasive or qualitative, the development of non-invasive quantitative assessments of tongue function is essential.</div></div><div><h3>Methods</h3><div>A prospective study (March 2022 − March 2024) included 38 ALS patients (categorized by bulbar or spinal onset) and 12 controls. Clinical symptoms were evaluated using the Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R). Tongue muscle elasticity was measured using shear wave elastography (LOGIQ® E9, 9 MHz).</div></div><div><h3>Results</h3><div>Median shear modulus of the genioglossus (GG) muscle was significantly lower in bulbar-onset ALS (7.80 kPa, range 5.41–10.08) compared to spinal-onset ALS (12.48 kPa, range 8.50–21.42) and controls (14.16 kPa, range 11.37–20.21). The geniohyoid (GH) muscle showed similar patterns. Both muscles showed significantly reduced elasticity in bulbar-onset ALS compared to controls (p < 0.05). The GG muscle elasticity showed strong positive correlation with bulbar symptom severity on the ALSFRS-R.</div></div><div><h3>Conclusions</h3><div>Reduced tongue muscle elasticity in bulbar-onset ALS, along with its correlation with bulbar symptoms, suggests the potential utility of this technique for both diagnosis and prognosis.</div></div><div><h3>Signature</h3><div>These findings indicate that shear wave elastography is a promising noninvasive tool for the quantitative assessment of tongue dysfunction in ALS.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111367"},"PeriodicalIF":3.6,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145154180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative monitoring of trigemino-palatal responses 术中三叉-腭反应监测

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-17 DOI: 10.1016/j.clinph.2025.2111006

Joao Leote , Ana Mirallave Pescador , Alba Díaz-Baamonde , José David Siado Mosquera , Sian Murace , Arjel Lejarde , Emily Lawson , Sinan Barazi , Jonathan Shapey , Jose Pedro Lavrador , Cristina Bleil , Josep Valls-Sole

{"title":"Intraoperative monitoring of trigemino-palatal responses","authors":"Joao Leote , Ana Mirallave Pescador , Alba Díaz-Baamonde , José David Siado Mosquera , Sian Murace , Arjel Lejarde , Emily Lawson , Sinan Barazi , Jonathan Shapey , Jose Pedro Lavrador , Cristina Bleil , Josep Valls-Sole","doi":"10.1016/j.clinph.2025.2111006","DOIUrl":"10.1016/j.clinph.2025.2111006","url":null,"abstract":"<div><h3>Objective</h3><div>Our study aim was to describe the methodology for intraoperative recording of trigemino-palatal responses during posterior fossa surgeries.</div></div><div><h3>Methods</h3><div>Trigeminal nerve stimuli (2–4 pulses with 200–500 µs duration, 2 ms inter-stimulus interval, 25–50 mA) was applied to V3 under the zygomatic arch. Responses were recorded through needle electrodes inserted bilaterally in the soft palate, and through surface electrodes embedded in the endotracheal tube. Onset latency (L), duration (D) and peak-to-peak amplitude (A) were measured in each triggered response.</div></div><div><h3>Results</h3><div>The trigemino-palatal responses were successfully recorded in 23 out of 38 patients, bilateral in 12 of them. Response data (mean and IC 95 %) were L: 42 ms [35–57 ms]; D:45 ms [23–61 ms]; A:67 µs [57–183 µs]. Vocal cords responses were also recorded to trigeminal V3 stimulation in six patients with L:40 ms [37–47 ms]; D:25 ms [18–65 ms], and A: 70 µs [37–96 µs].</div></div><div><h3>Conclusion</h3><div>Trigemino-palatal responses were obtained under general anesthesia and used for the monitorization of patients submitted to posterior fossa surgery. Further studies are needed to foster the use of these responses for intraoperative monitorization.</div></div><div><h3>Significance</h3><div>Trigeminal V2/V3 branches trigger brainstem palatal responses that remain obtainable after general anesthesia.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111006"},"PeriodicalIF":3.6,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic accuracy of the Gold Coast Criteria for amyotrophic lateral sclerosis: a systematic review and meta-analysis 黄金海岸标准对肌萎缩性侧索硬化症的诊断准确性：一项系统评价和荟萃分析

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-15 DOI: 10.1016/j.clinph.2025.2111005

Enzo von Quednow , Noor Husain , Paweł Łajczak , Guilherme Linha Secco , Aishwarya Koppanatham

{"title":"Diagnostic accuracy of the Gold Coast Criteria for amyotrophic lateral sclerosis: a systematic review and meta-analysis","authors":"Enzo von Quednow , Noor Husain , Paweł Łajczak , Guilherme Linha Secco , Aishwarya Koppanatham","doi":"10.1016/j.clinph.2025.2111005","DOIUrl":"10.1016/j.clinph.2025.2111005","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the diagnostic accuracy of Gold Coast Criteria (GCC) with Revised El Escorial Criteria (rEEC) and Awaji Criteria (AC) in suspected amyotrophic lateral sclerosis (ALS).</div></div><div><h3>Methods</h3><div>PubMed, EMBASE, Web of Science, Cochrane Library, and Google Scholar were searched through December 2024. Eligible studies assessed patients using GCC, rEEC, and/or AC, reporting or allowing calculation of sensitivity and specificity. Quality was evaluated using QUADAS-2 and STARD. “Probable+” included probable and definite classifications; “Possible+” encompassed possible to definite. Sensitivity analyses excluded the largest study with imputed data and included a sensitivity-only model. PRISMA-DTA compliant; PROSPERO CRD42025623678.</div></div><div><h3>Results</h3><div>Nine studies (n = 9656), all from ALS referral centers, were included. GCC showed higher sensitivity (∼95 %) than rEEC and AC Probable+ (59 % and 54 %) and Possible+ (84 % and 85 %), but lower specificity (66 %) vs. rEEC (Probable+ 94 %, Possible+ 77 %) and AC (Probable+ 94 %, Possible+ 82 %). GCC achieved the highest AUC (0.95) and diagnostic odds ratio (36.1). Sensitivity-only analysis confirmed GCC performance (97 %).</div></div><div><h3>Conclusions</h3><div>GCC demonstrated superior sensitivity, potentially facilitating earlier recognition and trial inclusion. Their lower specificity requires caution, particularly in low-prevalence contexts. Applicability in unselected neurology populations remains uncertain.</div></div><div><h3>Significance</h3><div>GCC may enable earlier ALS diagnosis and timely trial enrollment in referral centers.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111005"},"PeriodicalIF":3.6,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095731","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Phasic events, cyclic alternating pattern (CAP) and sleep disorders 相事件，循环交替模式（CAP）和睡眠障碍。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-14 DOI: 10.1016/j.clinph.2025.2111004

Liborio Parrino , Giulia Balella , Dario Bottignole , Andrea Melpignano , Ivana Rosenzweig , Giorgio Ughetti , Carlotta Mutti

{"title":"Phasic events, cyclic alternating pattern (CAP) and sleep disorders","authors":"Liborio Parrino , Giulia Balella , Dario Bottignole , Andrea Melpignano , Ivana Rosenzweig , Giorgio Ughetti , Carlotta Mutti","doi":"10.1016/j.clinph.2025.2111004","DOIUrl":"10.1016/j.clinph.2025.2111004","url":null,"abstract":"<div><div>Intermittent alpha rhythm, transient vertex sharp potentials, K-complexes, spindles, arousals, delta bursts, polyphasic bursts, sawtooth waves, muscle twitches, slow and rapid eye movements are distinct phasic events that occur throughout different sleep stages. During NREM sleep, arousal-related phasic events tend to aggregate into the ordered sequences of cyclic alternating pattern (CAP), which keeps the sleeping brain under control and provides a continuous balance between the programming centers (order) and the contingent psychological, organic and environmental factors (chaos). Due to its functional properties, CAP translates a condition of criticality and undergoes specific alterations in most sleep pathologies. The clinical applications of CAP are explored in sleep apnea syndrome, insomnia, narcolepsy, epilepsy, NREM and REM sleep parasomnias, as well as the involvement of CAP in cognitive processes and in critical care settings. During NREM sleep, the locus coeruleus (LC) exhibits infra-slow oscillatory activity with a periodicity that partially overlaps with that of CAP, suggesting a functional interaction between LC-driven noradrenergic rhythms and CAP dynamics. Through the structured collection of phasic events, CAP regulates sleep continuity, modulates responsiveness to internal and external stimuli and plays a coordinated activity in NREM sleep oscillations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111004"},"PeriodicalIF":3.6,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145079797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy 新生儿脑病足月新生儿与血糖异常相关的神经生理变化

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-09 DOI: 10.1016/j.clinph.2025.2111002

Jessy Parokaran Varghese , Elana F Pinchefsky , Saeed Montazeri , Daphne Kamino , Cecil D Hahn , Sampsa Vanhatalo , Emily WY Tam

{"title":"Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy","authors":"Jessy Parokaran Varghese , Elana F Pinchefsky , Saeed Montazeri , Daphne Kamino , Cecil D Hahn , Sampsa Vanhatalo , Emily WY Tam","doi":"10.1016/j.clinph.2025.2111002","DOIUrl":"10.1016/j.clinph.2025.2111002","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between hypo/hyperglycemia and EEG measures in term neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH).</div></div><div><h3>Methods</h3><div>Ninety-six neonates underwent concurrent continuous glucose monitoring (CGM) and EEG for 48 h within the first 72 h of life. Five-minute epochs of hypoglycemia (≤2.6 mmol/L; ≤47 mg/dL) and hyperglycemia (>10.1 mmol/L; >182 mg/dL) were identified. Continuous EEG data was segmented into 5-min epochs corresponding to 5-min CGM data. Visual EEG background score and 22 computational EEG measures were estimated and their relationship to dysglycemia was assessed after adjusting for hypoxia–ischemia severity and multiple testing.</div></div><div><h3>Results</h3><div>Among the 96 neonates, 12 had hypoglycemia, 16 had hyperglycemia, including 1 with both during the recording period. In the adjusted analyses, hyperglycemic epochs were associated with worse visual background scores (1.2, 95 %CI 0.51–1.89, q = 0.003) and 11 computational EEG measures. In contrast, hypoglycemic epochs were not associated with a significant change in visual background scores (−0.28, 95 %CI −0.66 − −0.10, q = 0.549), and were only associated with one computational EEG measure.</div></div><div><h3>Conclusions</h3><div>Hyperglycemia is temporally associated with changes in brain function in term neonates with NE treated with TH.</div></div><div><h3>Significance</h3><div>This temporal relationship suggests high glucose levels may contribute directly to brain injury after NE.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111002"},"PeriodicalIF":3.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive nerve stimulation normalization after FcRn inhibitor therapy in refractory myasthenia gravis: A case report FcRn抑制剂治疗难治性重症肌无力后重复神经刺激正常化1例报告

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-09 DOI: 10.1016/j.clinph.2025.2111001

Rajiv Wijesinghe, Richard Yitong Shao, Gaven Lin, Matthew Silsby

引用次数: 0