Clinical Neurophysiology最新文献

{"title":"Enhancing oscillatory dysfunctome in aphasia: Phase-dependent network effects of connectomic transcranial alternating current stimulation","authors":"Chester Yee-Nok Cheung,&nbsp;Anthony Pak-Hin Kong","doi":"10.1016/j.clinph.2026.2111712","DOIUrl":"10.1016/j.clinph.2026.2111712","url":null,"abstract":"<div><h3>Objective</h3><div>Connectomic transcranial alternating current stimulation (tACS) utilizes connectomic model to guide network-modulating tACS. Early application of connectomic tACS supported the feasibility of using phase-synchronization tACS to modulate connectivity within a symptom-predictive subnetwork (a.k.a. <em>dysfunctome</em>) to promote clinical benefit in post-stroke aphasia (PSA). However, the dysfunctome-modulatory patterns of in/anti-phase tACS remain unclear. This study investigates the dysfunctome-enhancing effects of in/anti-phase tACS applied to a centralized edge within the dysfunctome, and how individualized targeting pinpointing an individual’s weakened edge, may moderate these effects.</div></div><div><h3>Methods</h3><div>Nine individuals with PSA received single-session, double-blinded, 10-Hz tACS paired with speech therapy under five within-subject conditions: Generalized In-phase (GI), Generalized Anti-phase (GA), Individualized In-phase (II), Individualized Anti-phase (IA), and sham. Generalized conditions targeted an edge with the highest centrality within the dysfunctome that is universal to all participants. Individualized conditions pinpointed a centralized-but-weakened edge based on the individual’s dysfunctome profile. Dysfunctome and overall network changes were compared.</div></div><div><h3>Results</h3><div>GI and IA had a medium effect with marginal significance in producing greater increase in average connectivity of the dysfunctome than sham. The reverse pattern of phase-dependent effect in generalized and individualized conditions suggests a moderator role of baseline connectivity of the target edge.</div></div><div><h3>Conclusions</h3><div>In-phase tACS could potentially promote a dysfunctome-wide enhancement when targeted at an undisrupted centralized edge. Anti-phase tACS was more effective when the individual’s disrupted centralized edge was targeted, possibly via network reorganization mechanism.</div></div><div><h3>Significance</h3><div>Immediate network-modulatory effects of tACS indicate potential for clinical applications in precision neurorehabilitation of PSA or other network-based disorders.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111712"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Disrupted intracortical inhibition in the prefrontal cortex relates to cognitive dysfunction in post-COVID-19 condition: A TMS-EEG study","authors":"Elias P. Casula ,&nbsp;Sabrina Dezi ,&nbsp;Michele Maiella ,&nbsp;Davide Ferrazzoli ,&nbsp;Cristian Ripoli ,&nbsp;Antonio Oliviero ,&nbsp;Giacomo Koch ,&nbsp;Paola Ortelli ,&nbsp;Luca Sebastianelli ,&nbsp;Viviana Versace","doi":"10.1016/j.clinph.2026.2111709","DOIUrl":"10.1016/j.clinph.2026.2111709","url":null,"abstract":"<div><h3>Objective</h3><div>Dysfunction of GABA_Bergic intracortical inhibition has previously been demonstrated in the primary motor cortex of patients suffering from post-COVID19 condition (pCVD). Here, we searched for alterations in GABA_B-mediated inhibition in the prefrontal cortex (PFC), a crucial area for cognition.</div></div><div><h3>Methods</h3><div>Sixteen pCVD patients complaining cognitive complaints underwent a combined paired-pulse transcranial magnetic stimulation and electroencephalography (TMS-EEG) protocol of long-interval intracortical inhibition (LICI) over the left PFC. Global cognition was evaluated using the Montreal Cognitive Assessment. Twelve healthy volunteers (HV) matched for gender, age and education served as the control group.</div></div><div><h3>Results</h3><div>Patients with pCVD showed lower oscillatory activity and cognitive performance compared to HV (p &lt; 0.05). No significant LICI effects were observable in the oscillatory activity of pCVD patients, whereas these were observable in HV. A linear relationship between individual levels of gamma (r = -0.479; p = 0.030) and beta (r = -0.478; p = 0.031) frequencies inhibition and cognitive performance was observed in pCVD patients.</div></div><div><h3>Conclusions</h3><div>GABA_B- receptor mediated intracortical inhibition in the PFC is disrupted in pCVD patients with cognitive complaints and inversely correlated to cognitive performance.</div></div><div><h3>Significance</h3><div>TMS-EEG could be used to identify early alterations of cortical oscillatory activity in prefrontal regions related to the pCVD and inducing subtle cognitive decline.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111709"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroencephalography biomarkers in Huntington’s disease: A systematic review of resting-state and sleep EEG alterations","authors":"Sayeh Jalali ,&nbsp;Milad Asadollahi ,&nbsp;Mahdi Gouravani ,&nbsp;Alireza Beikmarzehei ,&nbsp;Mojtaba Shahbazi ,&nbsp;Kiarash Kazemi ,&nbsp;Armin Tafazolimoghadam ,&nbsp;Mohammadamin Parsaei ,&nbsp;Iman Kiani ,&nbsp;Hossein Sanjari Moghaddam ,&nbsp;Matthew J. Barrett ,&nbsp;Antonio L Teixeira","doi":"10.1016/j.clinph.2026.2111701","DOIUrl":"10.1016/j.clinph.2026.2111701","url":null,"abstract":"<div><h3>Objective</h3><div>To systematically review EEG-based biomarkers in Huntington’s disease across resting-state, sleep, medication response, and clinical correlation studies.</div></div><div><h3>Methods</h3><div>PubMed, Web of Science, and EMBASE databases were systematically searched for studies of sufficient methodological quality that examined EEG alterations in patients with HD or presymptomatic gene carriers (pre-HD).</div></div><div><h3>Results</h3><div>A total of 23 studies were included and categorized into resting-state EEG (n = 20), sleep EEG (n = 6), medication-related EEG (n = 3), and clinical correlation studies (n = 20). Resting-state EEG commonly showed reduced alpha and delta power in HD patients. Results for theta and beta band powers were more variable. Sleep EEG studies showed reduced theta power. Except for higher spindle density in unmedicated patients in one study, EEG was not significantly influenced by medications. Lastly, greater impairment in cognitive and motor function was associated with reduced alpha and theta power.</div></div><div><h3>Conclusion</h3><div>The observed alterations in spectral power and sleep EEG are helpful for understanding the neurophysiology of the disease. In order to investigate the potential of EEG as a tool for HD, further research with large sample sizes and standardized methods is needed.</div></div><div><h3>Significance</h3><div>This review highlights EEG as a promising, non-invasive biomarker for Huntington’s disease, with potential for clinical translation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111701"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theta-cordance as a biomarker of treatment response to intermittent theta burst stimulation in patients with treatment-resistant depression","authors":"Andreas Reissmann ,&nbsp;Maximilian Rupprecht ,&nbsp;Berthold Langguth ,&nbsp;Johanna Rischer ,&nbsp;Stefan Schoisswohl","doi":"10.1016/j.clinph.2026.2111710","DOIUrl":"10.1016/j.clinph.2026.2111710","url":null,"abstract":"<div><h3>Objective</h3><div>To test whether baseline or treatment-related changes in prefrontal theta cordance are associated with clinical outcome after intermittent theta burst stimulation (iTBS) for major depressive disorder (MDD).</div></div><div><h3>Methods</h3><div>Retrospective analysis of 30 inpatients receiving 10 sessions of left-sided iTBS over 2 weeks. Resting-state 19-channel EEG was processed to compute theta cordance (plus delta/alpha/beta) in predefined cortical clusters pre/post the iTBS treatment period. Depression was rated pre/post with the Hamilton Depression Rating Scale (HAM-D) and the Major Depression Inventory (MDI); correlations linked baseline values and change scores to symptom improvement.</div></div><div><h3>Results</h3><div>Baseline prefrontal theta cordance was not associated with outcome. Change scores were region-specific: responders showed greater occipital decreases (OC p = 0.036; MLOC p = 0.009) and a trend toward left-frontal increases (MLFC p = 0.072); exploratory alpha and delta effects also emerged.</div></div><div><h3>Conclusions</h3><div>Theta cordance may predict and track symptom improvement following iTBS, indicating state-dependent neurophysiology.</div></div><div><h3>Significance</h3><div>Theta cordance may serve as a dynamic, region-specific EEG marker to monitor and personalize iTBS; prospective validation is warranted.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111710"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147354174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Individual alpha frequency before the sleep onset: towards a personalized neurophysiological characterization of insomnia","authors":"Elisabetta Fasiello ,&nbsp;Maurizio Gorgoni ,&nbsp;Francesca Berra ,&nbsp;Roberto Salabelle ,&nbsp;Francesca Casoni ,&nbsp;Paola Proserpio ,&nbsp;Vincenza Castronovo ,&nbsp;Luigi Ferini-Strambi ,&nbsp;Luigi De Gennaro ,&nbsp;Andrea Galbiati","doi":"10.1016/j.clinph.2026.2111720","DOIUrl":"10.1016/j.clinph.2026.2111720","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the electrophysiological features of the alpha band and Individual Alpha Frequency (IAF) before the Sleep Onset (SO) period in Insomnia Disorder patients (ID) and Healthy Controls (HCs). We hypothesized that IAF, as an individualized electrophysiological marker rather than broadband alpha power, could better capture individual sleep-initiation alterations characterizing ID and Sleep State Misperception (SSM).</div></div><div><h3>Methods</h3><div>Polysomnographic recordings were analyzed to assess changes in alpha activity and IAF Before-SO in occipital regions. Correlational analyses were conducted to investigate associations between the alpha activity, IAF, sleep parameters, and SSM.</div></div><div><h3>Results</h3><div>Compared to HC, ID patients showed higher occipital IAF power during the Before-SO, while no group differences emerged in the broadband alpha activity. Correlational analyses revealed that faster IAF was associated with longer sleep latency and delayed transition to deep sleep, whereas higher IAF power was related to greater insomnia severity and stronger SSM.</div></div><div><h3>Conclusions</h3><div>These findings suggest that IAF during the period preceding the SO is a sensitive marker of cortical arousal, contributing to impaired sleep initiation and distorted sleep perception.</div></div><div><h3>Significance</h3><div>These findings underscore the potential role of the IAF as an electrophysiological marker of ID pathophysiology and a target for personalized therapeutic interventions.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111720"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Maximal motor unit firing rates decline with amyotrophic lateral sclerosis progression","authors":"Gabriel L. Fernandes ,&nbsp;Lucas B.R. Orssatto ,&nbsp;Matheus D. Pinto ,&nbsp;Joao S. Henkin ,&nbsp;Ehsan Shandiz ,&nbsp;Pamela A. McCombe ,&nbsp;Robert D. Henderson ,&nbsp;Gabriel S. Trajano","doi":"10.1016/j.clinph.2026.2111697","DOIUrl":"10.1016/j.clinph.2026.2111697","url":null,"abstract":"<div><h3>Objective</h3><div>Amyotrophic lateral sclerosis (ALS) is characterised by progressive degeneration of upper and lower motor neurons and their motor units (MUs). MU loss is compensated by collateral sprouting and reinnervation of muscle fibres. There is limited information about the properties of these surviving MUs as these processes take place. High-density surface electromyography (HD-sEMG) decomposition enables non-invasive analysis of individual MU firing behaviour during maximal voluntary contractions and assess their changes with ALS progression.</div></div><div><h3>Methods</h3><div>Thirty-nine individuals with ALS (24 men; mean age 63 ± 16 years) completed up to five visits (interval 20.0 ± 7.9 weeks). Tibialis anterior HD-sEMG recordings during maximal contractions were decomposed into individual MU spike trains, from which maximal firing rates were quantified. Muscle strength was assessed with the Medical Research Council (MRC) scale, and global function with the revised ALS Functional Rating Scale (ALSFRS-R).</div></div><div><h3>Results</h3><div>Maximal MU firing rates declined significantly over time [–0.32 Hz/month, (95% CI –0.44; –0.19)], regardless of MRC scores. Across participants, maximal firing rates decreased by 2.38 Hz (1.78; 2.98) for each 1-point reduction in MRC and by 0.54 Hz for each ALSFRS-R point (–0.83; –0.26).</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that maximal MU firing rates decline as ALS progresses, suggesting that the surviving motor unit undergo progressive pathophysiological changes as motor neurons degenerate. HD-sEMG MU firing-rates analysis appeared more sensitive than MRC in detecting early deterioration in muscle decline.</div></div><div><h3>Significance</h3><div>Maximal firing rates analysis has the potential to serve as a quantitative clinical biomarker of neuromotor system degeneration, complementing global functional scales in clinical monitoring.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111697"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the surface: A prospective case-control study of electromyography in cervical dystonia","authors":"S.A.J.E.A. Lagerweij ,&nbsp;M. Smit ,&nbsp;L.M. Centen ,&nbsp;J.M.C. van Dijk ,&nbsp;D.L.M. Oterdoom ,&nbsp;M.E. van Egmond ,&nbsp;J.W. Elting ,&nbsp;M.A.J. Tijssen","doi":"10.1016/j.clinph.2026.2111708","DOIUrl":"10.1016/j.clinph.2026.2111708","url":null,"abstract":"<div><h3>Objective</h3><div>To identify potential EMG monitoring biomarkers for CD by comparing cervical muscle activity in patients and controls.</div></div><div><h3>Methods</h3><div>Fifteen CD patients and fifteen controls underwent bilateral EMG recordings from the sternocleidomastoid (SCM) and splenius capitis (SPL) muscles during rest and motor tasks. Power spectral density (PSD) in the 4–12 Hz range, co-contraction, overflow and intermuscular coherence were analyzed. Group differences were assessed with Mann-Whitney U tests and associations between EMG features and clinical severity scores were evaluated using Spearman correlations.</div></div><div><h3>Results</h3><div>CD patients showed significantly increased 4–12 Hz PSD across all neck muscles and tasks. Co-contraction and overflow were consistently observed and quantifiable. Intermuscular coherence was notably elevated in SCM pairs during active tasks. Preliminary correlations were found between PSD measures and clinical scores.</div></div><div><h3>Conclusions</h3><div>The study confirms four distinct EMG characteristics in CD: elevated 4–12 Hz PSD, co-contraction, overflow and intermuscular coherence, supporting their potential as objective monitoring biomarkers.</div></div><div><h3>Significance</h3><div>These findings provide electrophysiological validation of key EMG features in CD and highlight their potential for integration into research and clinical assessment, pending further methodological standardization.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111708"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-branch convolutional neural network and intracranial EEG high-frequency oscillations predict post-surgical seizure outcomes","authors":"Madhumathi Devaraj ,&nbsp;Yihe Chen ,&nbsp;Shuang Wang ,&nbsp;Michael R. Sperling ,&nbsp;Noa Herz ,&nbsp;Chenyuan Wu ,&nbsp;Richard Staba ,&nbsp;Jerome Engel Jr ,&nbsp;Itzhak Fried ,&nbsp;Charles Mikell ,&nbsp;Sima Mofakham ,&nbsp;Petar M. Djuric ,&nbsp;Shennan Aibel Weiss","doi":"10.1016/j.clinph.2026.2111702","DOIUrl":"10.1016/j.clinph.2026.2111702","url":null,"abstract":"<div><h3>Objective</h3><div>Pathological High-Frequency Oscillations (HFOs) identify epileptogenic cortex, but their surgical utility is unproven. Current epilepsy surgery planning relies on a “gold standard” multidisciplinary consensus. We tested if a Convolutional Neural Network (CNN), leveraging HFO features, neuroanatomy, and surgical boundaries, could predict seizure freedom.</div></div><div><h3>Methods</h3><div>HFOs were detected during NREM sleep EEG in 78 pre-surgical patients. A three-branch CNN was trained using SEEG contact inputs: stereotaxic coordinates, resection status, and 37 HFO features, utilizing known post-operative seizure outcome. Branches encoded spatial, electrophysiological, and surgical data. Outputs were concatenated and processed by fully connected layers; a final sigmoid layer predicted post-operative seizure freedom probability. Univariate HFO feature analysis employed two-way mixed-effect ANOVAs.</div></div><div><h3>Results</h3><div>The HFO-informed CNN model distinguished seizure-free patients with 92% accuracy using fivefold cross-validation. Univariate analysis suggested that fast ripples, especially those superimposed on epileptiform spikes, are important HFO features for the model.</div></div><div><h3>Conclusions</h3><div>A trained CNN model integrating HFO features, neuroanatomy, and surgical boundaries can accurately predict seizure freedom following “gold standard” surgical planning.</div></div><div><h3>Significance</h3><div>This CNN model, using inter-ictal non-REM sleep recordings, can predict surgical success and allow counterfactual virtual resections to be iteratively tested by the CNN ML to potentially improve post-operative seizure outcome.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111702"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated gamma spectral event peak power during auditory chirp is associated with neuropsychiatric features in Fragile X syndrome","authors":"Yanchen Liu ,&nbsp;Peyton Siekierski ,&nbsp;Lisa A. De Stefano ,&nbsp;Grace Westerkamp ,&nbsp;Lauren Ethridge ,&nbsp;Elizabeth Blank ,&nbsp;Makoto Miyakoshi ,&nbsp;Ryan V. Thorpe ,&nbsp;Stephanie R. Jones ,&nbsp;Craig Erickson ,&nbsp;Paul S. Horn ,&nbsp;Ernest V. Pedapati","doi":"10.1016/j.clinph.2026.2111713","DOIUrl":"10.1016/j.clinph.2026.2111713","url":null,"abstract":"<div><h3>Objective</h3><div>Investigate transient, non-averaged electroencephalography (EEG) signals in the gamma frequency band during an auditory chirp paradigm in individuals with Fragile X syndrome (FXS), a population characterized by elevated background gamma power, and to assess their relationship with clinical features.</div></div><div><h3>Methods</h3><div>Source-localized EEG responses to auditory chirp stimulus were studied in 36 individuals with FXS and 39 typically developing controls (TDC). Transient high-power gamma-band events were extracted using a thresholding approach. Gamma event properties were compared between groups and correlated with mean EEG features and clinical measures.</div></div><div><h3>Results</h3><div>In male FXS subjects, gamma event peak power was increased in the temporal source and lacked correlation with inter-trial coherence (ITC). Event rate, duration, and frequency span were similar between groups. Event peak power was positively correlated with obsessive and stereotyped behavior scales.</div></div><div><h3>Conclusions</h3><div>Peak power of transient gamma events during auditory response is tonically elevated, dissociated from phase synchronization, and associated with neuropsychiatric features in FXS.</div></div><div><h3>Significance</h3><div>Identifying a tonic elevation of gamma event peak power in FXS during auditory processing suggests altered neural circuit mechanisms underlying aberrant gamma activity. This provides a more direct basis for understanding auditory hypersensitivity, fostering opportunities for back translation and targeted treatment development.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111713"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of low-intensity transcranial focused ultrasound targeting the motor thalamus for motor impairment after basal ganglia stroke","authors":"Zhongfei Bai ,&nbsp;Dan Yu ,&nbsp;Jack Jiaqi Zhang ,&nbsp;Feifei Zhu ,&nbsp;Shan Liang ,&nbsp;Minxia Jin ,&nbsp;Ke Zeng ,&nbsp;Jiani Lu ,&nbsp;Wenting Qin ,&nbsp;Ulf Ziemann ,&nbsp;Lingjing Jin","doi":"10.1016/j.clinph.2026.2111707","DOIUrl":"10.1016/j.clinph.2026.2111707","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111707"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}