Clinical Neurophysiology最新文献

{"title":"Determining predictive value of intraoperative electroencephalography changes for delirium development after cardiovascular surgeries","authors":"Fei Gao, Dan F. Wang, Fu S. Xue","doi":"10.1016/j.clinph.2024.08.015","DOIUrl":"10.1016/j.clinph.2024.08.015","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 12-13"},"PeriodicalIF":3.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142167891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive modeling based on functional connectivity of interictal scalp EEG for infantile epileptic spasms syndrome","authors":"Sotaro Kanai ,&nbsp;Masayoshi Oguri ,&nbsp;Tohru Okanishi ,&nbsp;Yosuke Miyamoto ,&nbsp;Masanori Maeda ,&nbsp;Kotaro Yazaki ,&nbsp;Ryuki Matsuura ,&nbsp;Takenori Tozawa ,&nbsp;Satoru Sakuma ,&nbsp;Tomohiro Chiyonobu ,&nbsp;Shin-ichiro Hamano ,&nbsp;Yoshihiro Maegaki","doi":"10.1016/j.clinph.2024.08.016","DOIUrl":"10.1016/j.clinph.2024.08.016","url":null,"abstract":"<div><h3>Objective</h3><p>This study aims to delineate the electrophysiological variances between patients with infantile epileptic spasms syndrome (IESS) and healthy controls and to devise a predictive model for long-term seizure outcomes.</p></div><div><h3>Methods</h3><p>The cohort consisted of 30 individuals in the seizure-free group, 23 in the seizure-residual group, and 20 in the control group. We conducted a comprehensive analysis of pretreatment electroencephalography, including the relative power spectrum (rPS), weighted phase-lag index (wPLI), and network metrics. Follow-up EEGs at 2 years of age were also analyzed to elucidate physiological changes among groups.</p></div><div><h3>Results</h3><p>Infants in the seizure-residual group exhibited increased rPS in theta and alpha bands at IESS onset compared to the other groups (all <em>p</em> &lt; 0.0001). The control group showed higher rPS in fast frequency bands, indicating potentially enhanced cognitive function. The seizure-free group presented increased wPLI across all frequency bands (all <em>p</em> &lt; 0.0001). Our predictive model utilizing wPLI anticipated long-term outcomes at IESS onset (area under the curve 0.75).</p></div><div><h3>Conclusion</h3><p>Our findings demonstrated an initial “hypersynchronous state” in the seizure-free group, which was ameliorated following successful treatment.</p></div><div><h3>Significance</h3><p>This study provides a predictive model utilizing functional connectivity and insights into the diverse electrophysiology observed among outcome groups of IESS.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 37-48"},"PeriodicalIF":3.7,"publicationDate":"2024-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002438/pdfft?md5=fc647bdbf94ed58c959df3559cdb9326&pid=1-s2.0-S1388245724002438-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning for (non–)epileptic tissue detection from the intraoperative electrocorticogram","authors":"Sem Hoogteijling ,&nbsp;Eline V. Schaft ,&nbsp;Evi H.M. Dirks ,&nbsp;Sven Straumann ,&nbsp;Matteo Demuru ,&nbsp;Pieter van Eijsden ,&nbsp;Tineke Gebbink ,&nbsp;Willem M. Otte ,&nbsp;Geertjan M. Huiskamp ,&nbsp;Maryse A. van ’t Klooster ,&nbsp;Maeike Zijlmans ,&nbsp;the RESPect database group","doi":"10.1016/j.clinph.2024.08.012","DOIUrl":"10.1016/j.clinph.2024.08.012","url":null,"abstract":"<div><h3>Objective</h3><p>Clinical visual intraoperative electrocorticography (ioECoG) reading intends to localize epileptic tissue and improve epilepsy surgery outcome. We aimed to understand whether machine learning (ML) could complement ioECoG reading, how subgroups affected performance, and which ioECoG features were most important.</p></div><div><h3>Methods</h3><p>We included 91 ioECoG-guided epilepsy surgery patients with Engel 1A outcome. We allocated 71 training and 20 test set patients. We trained an extra trees classifier (ETC) with 14 spectral features to classify ioECoG channels as covering resected or non-resected tissue. We compared the ETC’s performance with clinical ioECoG reading and assessed whether patient subgroups affected performance. Explainable artificial intelligence (xAI) unveiled the most important ioECoG features learnt by the ETC.</p></div><div><h3>Results</h3><p>The ETC outperformed clinical reading in five test set patients, was inferior in six, and both were inconclusive in nine. The ETC performed best in the tumor subgroup (area under ROC curve: 0.84 [95%CI 0.79–0.89]). xAI revealed predictors of resected (relative theta, alpha, and fast ripple power) and non-resected tissue (relative beta and gamma power).</p></div><div><h3>Conclusions</h3><p>Combinations of subtle spectral ioECoG changes, imperceptible by the human eye, can aid healthy and pathological tissue discrimination.</p></div><div><h3>Significance</h3><p>ML with spectral ioECoG features can support, rather than replace, clinical ioECoG reading, particularly in tumors.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 14-25"},"PeriodicalIF":3.7,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142169285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nerve sonography to detect intraneural microvascularity in patients with peripheral neuropathy","authors":"Toshiyuki Hayashi,&nbsp;Noriko Matsumoto,&nbsp;Seira Hatake,&nbsp;Yuho Takeshi,&nbsp;Kentaro Suzuki,&nbsp;Yasuhiro Nishiyama,&nbsp;Hiroshi Nagayama,&nbsp;Kazumi Kimura","doi":"10.1016/j.clinph.2024.08.011","DOIUrl":"10.1016/j.clinph.2024.08.011","url":null,"abstract":"<div><h3>Objective</h3><p>We assessed microvessel flow within peripheral nerves using nerve sonography in patients with peripheral neuropathy.</p></div><div><h3>Methods</h3><p>This study included consecutive patients with peripheral neuropathy who were admitted to our hospital. The patients were divided into two groups: inflammatory neuropathies for immune-mediated neuropathies, such as Guillain − Barré syndrome and chronic inflammatory demyelinating polyneuropathy, and the rest were defined as non-inflammatory neuropathies. We assessed nerve size and intraneural blood flow at four sites on each median and ulnar nerve. Blood flow was evaluated using color Doppler imaging, advanced dynamic flow (ADF), and superb microvascular imaging (SMI) techniques.</p></div><div><h3>Results</h3><p>Thirty-nine patients (median age, 60.0 years; 20 male) were enrolled in this study. An increase in intraneural blood flow was observed in five patients when evaluated by color Doppler, five patients by ADF, and 13 patients by SMI. An overall analysis of the three methods showed that intraneural blood flow was significantly higher in patients with inflammatory neuropathy than in those with non-inflammatory neuropathy (54.2% vs. 0%, p = 0.0005).</p></div><div><h3>Conclusions</h3><p>Intraneural hypervascularization is more frequent in patients with inflammatory neuropathy than in those with non-inflammatory neuropathy.</p></div><div><h3>Significance</h3><p>Evaluation of microvessel flow within peripheral nerves may contribute to the diagnosis of peripheral neuropathy.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"166 ","pages":"Pages 244-249"},"PeriodicalIF":3.7,"publicationDate":"2024-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142125081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age-related differences in delta-beta phase-amplitude coupling in autistic individuals","authors":"Eleni Kroupi ,&nbsp;Emily JH Jones ,&nbsp;Bethany Oakley ,&nbsp;Jan Buitelaar ,&nbsp;Tony Charman ,&nbsp;Eva Loth ,&nbsp;Declan Murphy ,&nbsp;Aureli Soria-Frisch","doi":"10.1016/j.clinph.2024.08.010","DOIUrl":"10.1016/j.clinph.2024.08.010","url":null,"abstract":"<div><h3>Objective</h3><p>We aim to investigate the relationship between the core symptoms of autism, anxiety levels, and attention deficit hyperactivity disorder (ADHD) traits, and a non-autism-specific, neurophysiological metric, the Delta-Beta phase-amplitude coupling (PAC), extracted from the resting-state EEG for autistic and non-autistic populations across three different age groups (children, adolescents, and adults).</p></div><div><h3>Methods</h3><p>We analyze the eyes-open resting-state EEG of 371 individuals. We applied a phase de-biasing PAC algorithm expected to result in a more accurate PAC estimate than other PAC methodologies available in the literature.</p></div><div><h3>Results</h3><p>In the adult group, we found a significant increase of the delta-beta PAC in the autistic subgroup who met the Autism Diagnostic Observation Schedule-2 (ADOS-2) Autism Diagnostic Interview-Revised (ADR-R) ADOS-2/ADI-R threshold compared to non-autistic individuals. The differences seem age-specific since we found no statistically significant differences in the children and adolescent populations. Moreover, we found a significant positive correlation with the restricted and repetitive behaviours score of the ADOS-2 diagnostic instrument and with ADHD hyperactivity/impulsivity in the entire autistic cohort.</p></div><div><h3>Conclusions</h3><p>The neurophysiological differences we found only in the autistic individuals that meet the thresholds also point out the need for future studies that look for autistic neurodiverse subgroups beyond age.</p></div><div><h3>Significance</h3><p>The delta-beta debiasing PAC (dPAC) may potentially serve as a severity biomarker in the autistic population.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 74-83"},"PeriodicalIF":3.7,"publicationDate":"2024-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142263149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG-based sensorimotor neurofeedback for motor neurorehabilitation in children and adults: A scoping review","authors":"Elena Cioffi ,&nbsp;Anna Hutber ,&nbsp;Rob Molloy ,&nbsp;Sarah Murden ,&nbsp;Aaron Yurkewich ,&nbsp;Adam Kirton ,&nbsp;Jean-Pierre Lin ,&nbsp;Hortensia Gimeno ,&nbsp;Verity M. McClelland","doi":"10.1016/j.clinph.2024.08.009","DOIUrl":"10.1016/j.clinph.2024.08.009","url":null,"abstract":"<div><h3>Objective</h3><div>Therapeutic interventions for children and young people with dystonia and dystonic/dyskinetic cerebral palsy are limited. EEG-based neurofeedback is emerging as a neurorehabilitation tool. This scoping review maps research investigating EEG-based sensorimotor neurofeedback in adults and children with neurological motor impairments, including augmentative strategies.</div></div><div><h3>Methods</h3><div>MEDLINE, CINAHL and Web of Science databases were searched up to 2023 for relevant studies. Study selection and data extraction were conducted independently by at least two reviewers.</div></div><div><h3>Results</h3><div>Of 4380 identified studies, 133 were included, only three enrolling children. The most common diagnosis was adult-onset stroke (77%). Paradigms mostly involved upper limb motor imagery or motor attempt. Common neurofeedback modes included visual, haptic and/or electrical stimulation. EEG parameters varied widely and were often incompletely described. Two studies applied augmentative strategies. Outcome measures varied widely and included classification accuracy of the Brain-Computer Interface, degree of enhancement of mu rhythm modulation or other neurophysiological parameters, and clinical/motor outcome scores. Few studies investigated whether functional outcomes related specifically to the EEG-based neurofeedback.</div></div><div><h3>Conclusions</h3><div>There is limited evidence exploring EEG-based sensorimotor neurofeedback in individuals with movement disorders, especially in children. Further clarity of neurophysiological parameters is required to develop optimal paradigms for evaluating sensorimotor neurofeedback.</div></div><div><h3>Significance</h3><div>The expanding field of sensorimotor neurofeedback offers exciting potential as a non-invasive therapy. However, this needs to be balanced by robust study design and detailed methodological reporting to ensure reproducibility and validation that clinical improvements relate to induced neurophysiological changes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 143-166"},"PeriodicalIF":3.7,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002360/pdfft?md5=5dcac0bafd3ee837beadc30bf1c26596&pid=1-s2.0-S1388245724002360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142315042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Functional and structural maturation of auditory cortex from 2 months to 2 years old","authors":"Yuhan Chen ,&nbsp;Heather L. Green ,&nbsp;Jeffrey I. Berman ,&nbsp;Mary E. Putt ,&nbsp;Katharina Otten ,&nbsp;Kylie Mol ,&nbsp;Marybeth McNamee ,&nbsp;Olivia Allison ,&nbsp;Emily S. Kuschner ,&nbsp;Mina Kim ,&nbsp;Luke Bloy ,&nbsp;Song Liu ,&nbsp;Tess Yount ,&nbsp;Timothy P.L. Roberts ,&nbsp;J. Christopher Edgar","doi":"10.1016/j.clinph.2024.08.007","DOIUrl":"10.1016/j.clinph.2024.08.007","url":null,"abstract":"<div><h3>Background</h3><p>In school-age children, the myelination of the auditory radiation thalamocortical pathway is associated with the latency of auditory evoked responses, with the myelination of thalamocortical axons facilitating the rapid propagation of acoustic information. Little is known regarding this auditory system function-structure association in infants and toddlers.</p></div><div><h3>Methods and Participants</h3><p>The present study tested the hypothesis that maturation of auditory radiation white-matter microstructure (e.g., fractional anisotropy (FA); measured using diffusion-weighted MRI) is associated with the latency of the infant auditory response (the P2m response, measured using magnetoencephalography, MEG) in a cross-sectional (<em>N</em> = 47, 2 to 24 months, 19 females) as well as longitudinal cohort (<em>N</em> = 18, 2 to 29 months, 8 females) of typically developing infants and toddlers. Of 18 longitudinal infants, 2 infants had data from 3 timepoints and 16 infants had data from 2 timepoints.</p></div><div><h3>Results</h3><p>In the cross-sectional sample, non-linear maturation of P2m latency and auditory radiation diffusion measures were observed. Auditory radiation diffusion accounted for significant variance in P2m latency, even after removing the variance associated with age in both P2m latency and auditory radiation diffusion measures. In the longitudinal sample, latency and FA associations could be observed at the level of a single child.</p></div><div><h3>Conclusions</h3><p>Findings provide strong support for the hypothesis that an increase in thalamocortical neural conduction velocity, due to increased axon diameter and/or myelin maturation, contributes to a decrease in the infant P2m auditory evoked response latency.</p></div><div><h3>Significance</h3><p>Infant multimodal brain imaging identifies brain mechanisms contributing to the rapid changes in neural circuit activity during the first two years of life.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"166 ","pages":"Pages 232-243"},"PeriodicalIF":3.7,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002359/pdfft?md5=9eaebb1f32782d80425cc9cbfc5b7f36&pid=1-s2.0-S1388245724002359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142096272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repeated spaced cortical paired associative stimulation promotes additive plasticity in the human parietal-motor circuit","authors":"Elana R. Goldenkoff ,&nbsp;Joseph A. Deluisi ,&nbsp;Taraz G. Lee ,&nbsp;Benjamin M. Hampstead ,&nbsp;Stephan F. Taylor ,&nbsp;Thad A. Polk ,&nbsp;Michael Vesia","doi":"10.1016/j.clinph.2024.08.005","DOIUrl":"10.1016/j.clinph.2024.08.005","url":null,"abstract":"<div><h3>Objective</h3><p>Repeated spaced sessions of repetitive transcranial magnetic stimulation (TMS) to the human primary motor cortex can lead to dose-dependent increases in motor cortical excitability. However, this has yet to be demonstrated in a defined cortical circuit. We aimed to examine the effects of repeated spaced cortical paired associative stimulation (cPAS) on excitability in the motor cortex.</p></div><div><h3>Methods</h3><p>cPAS was delivered to the primary motor cortex (M1) and posterior parietal cortex (PPC) with two coils. In the multi-dose condition, three sessions of cPAS were delivered 50-min apart. The single-dose condition had one session of cPAS, followed by two sessions of a control cPAS protocol. Motor-evoked potentials were evaluated before and up to 40 min after each cPAS session as a measure of cortical excitability.</p></div><div><h3>Results</h3><p>Compared to a single dose of cPAS, motor cortical excitability significantly increased after multi-dose cPAS. Increasing the number of cPAS sessions resulted in a cumulative, dose-dependent effect on excitability in the motor cortex, with each successive cPAS session leading to notable increases in potentiation.</p></div><div><h3>Conclusion</h3><p>Repeated spaced cPAS sessions summate to increase motor cortical excitability induced by single cPAS.</p></div><div><h3>Significance</h3><p>Repeated spaced cPAS could potentially restore abilities lost due to disorders like stroke.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"166 ","pages":"Pages 202-210"},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002323/pdfft?md5=79ad82491debe21af488703a2c2ce410&pid=1-s2.0-S1388245724002323-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of transcranial electrical stimulation on simultaneous stereoelectroencephalography recordings: A randomized sham-controlled study","authors":"Sara Simula ,&nbsp;Julia Makhalova ,&nbsp;Francesca Pizzo ,&nbsp;Elodie Garnier ,&nbsp;Giada Damiani ,&nbsp;Borja Mercadal ,&nbsp;Maria Chiara Biagi ,&nbsp;Ricardo Salvador ,&nbsp;Samuel Medina-Villalon ,&nbsp;Giulio Ruffini ,&nbsp;Fabrice Wendling ,&nbsp;Christian George Bénar ,&nbsp;Fabrice Bartolomei","doi":"10.1016/j.clinph.2024.08.003","DOIUrl":"10.1016/j.clinph.2024.08.003","url":null,"abstract":"<div><h3>Objective</h3><p>Clinical exploitation of transcranial electrical stimulation for focal epilepsy treatment lacks quantification of the underlying neurophysiological changes. This study explores the immediate effects of transcranial alternating (tACS) and direct (tDCS) current stimulation on local and network brain activity using simultaneous stereoelectroencephalography (SEEG) recordings.</p></div><div><h3>Methods</h3><p>Patients were randomized for personalized tACS (n = 5) or tDCS (n = 6). Active stimulation (20 min) was preceded by sham stimulation (20 min). Changes in interictal epileptiform discharges (IED), functional connectivity (FC) and power spectral density (PSD) were quantified against baseline.</p></div><div><h3>Results</h3><p>Results demonstrated variable responses. Spike rate decreased in 2/6 subjects following sham and tDCS, while 2/6 showed an increase. Alpha power and aperiodic PSD components generally increased during and after tDCS but decreased following tACS. FC changes varied among subjects and were detectable even during sham sessions.</p></div><div><h3>Conclusions</h3><p>Strong variability suggests that tES does not have a univocal effect on immediate changes in IED or FC, possibly due to the single session format and challenges in affecting subcortical areas.</p></div><div><h3>Significance</h3><p>This is the first study to examine intracranial FC changes during tACS and tDCS, highlighting the importance of sham comparisons and individual variability in tES response, offering valuable insights into its application for epilepsy treatment.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"166 ","pages":"Pages 211-222"},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142048329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vestibular prepulse inhibition of the human blink reflex","authors":"Matteo Ciocca ,&nbsp;Sarah Hosli ,&nbsp;Zaeem Hadi ,&nbsp;Mohammad Mahmud ,&nbsp;Yen F Tai ,&nbsp;Barry M Seemungal","doi":"10.1016/j.clinph.2024.08.008","DOIUrl":"10.1016/j.clinph.2024.08.008","url":null,"abstract":"<div><h3>Objective</h3><p>Auditory and somatosensory prepulses are commonly used to assess prepulse inhibition (PPI). The effect of a vestibular prepulse upon blink reflex excitability has not been hitherto assessed.</p></div><div><h3>Methods</h3><p>Twenty-two healthy subjects and two patients with bilateral peripheral vestibular failure took part in the study. Whole body yaw rotation in the dark provided a vestibular inertial prepulse. Blink reflex was electrically evoked after the end of the rotation. The amplitude of R1 and the area-under-the-curve (area) of the blink reflex R2 and R2c responses were recorded and analysed.</p></div><div><h3>Results</h3><p>A vestibular prepulse inhibited the R2 (<em>p</em> &lt; 0.001) and R2c area (<em>p</em> &lt; 0.05). Increasing the angular acceleration did not increase the R2 and R2c inhibition (<em>p</em> &gt; 0.05). Voluntary suppression of the vestibulo-ocular reflex did not affect the magnitude of inhibition (<em>p</em> &gt; 0.05). Patients with peripheral vestibular failure did not show any inhibition.</p></div><div><h3>Conclusions</h3><p>Our data support a vestibular gating mechanism in humans.</p></div><div><h3>Significance</h3><p>The main brainstem nucleus mediating PPI – the pedunculopontine nucleus (PPN) – is heavily vestibular responsive, which is consistent with our findings of a vestibular-mediated PPI. Our technique may be used to interrogate the fidelity of brain circuits mediating vestibular-related PPN functions. Given the PPN’s importance in human postural control, our technique may also provide a neurophysiological biomarker of balance.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"167 ","pages":"Pages 1-11"},"PeriodicalIF":3.7,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002335/pdfft?md5=9e0f533784e898d7edb2745849415dce&pid=1-s2.0-S1388245724002335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142128349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}