Clinical Neurophysiology最新文献_第10页

Effects of attentional deployment training for relieving negative emotion in individuals with subthreshold depression 注意力调配训练对缓解阈值下抑郁症患者负面情绪的影响

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-29 DOI: 10.1016/j.clinph.2024.06.009

Shuyu Li , Shuang Li , Tao Ding , Sijia Liu , Xiuyan Guo , Zhiyuan Liu

{"title":"Effects of attentional deployment training for relieving negative emotion in individuals with subthreshold depression","authors":"Shuyu Li , Shuang Li , Tao Ding , Sijia Liu , Xiuyan Guo , Zhiyuan Liu","doi":"10.1016/j.clinph.2024.06.009","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.06.009","url":null,"abstract":"<div><h3>Objective</h3><p>As a prodromal stage to major depressive disorder (MDD), subthreshold depression (StD) has a higher prevalence in the population, resulting in a greater healthcare burden. StD individuals’ current negative emotion could be moderated by attentional deployment. However, it remains unclear whether attentional deployment training can mitigate subsequent negative emotion in StD individuals.</p></div><div><h3>Methods</h3><p>Based on 160 participants, we combined decision task (Experiment 1, <em>N</em> = 69), eye-tracking (Experiment 2, <em>N</em> = 40), and EEG (Experiment 3, <em>N</em> = 51) techniques to investigate how one-week attentional deployment (gain-focus, GF) training modulated the emotional processing of negative stimulus and its underlying neural correlates in StD individuals.</p></div><div><h3>Results</h3><p>After one-week GF training, StD individuals significantly reduced the first fixation time and total fixation time on the negative part (missed opportunities) of decision outcome and showed a decrease in emotional sensitivity to missed opportunities. An increase in N1 and decrease in P3 and LPP (late positive potentials) amplitudes, as well as a decrease in alpha oscillation, were observed when StD individuals faced missed opportunities after training. Additionally, the extent of reduction in StD individuals’ emotional sensitivity to missed opportunities could be significantly predicted by the degree of decrease in alpha oscillation.</p></div><div><h3>Conclusion</h3><p>One-week attentional deployment training could modulate negative emotion in StD individuals and the degree of change in alpha oscillation might act as an objective indicator for the effectiveness of training.</p></div><div><h3>Significance</h3><p>Our study provides a convenient and effective approach to alleviate the negative emotion of StD individuals.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141593592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures 半球内背侧前运动皮层和初级运动皮层双部位 TMS 连接测量的测试-再测可靠性。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-19 DOI: 10.1016/j.clinph.2024.06.006

Robin E. Heemels , Sian Ademi , Melina Hehl

{"title":"Test-retest reliability of intrahemispheric dorsal premotor and primary motor cortex dual-site TMS connectivity measures","authors":"Robin E. Heemels , Sian Ademi , Melina Hehl","doi":"10.1016/j.clinph.2024.06.006","DOIUrl":"10.1016/j.clinph.2024.06.006","url":null,"abstract":"<div><h3>Objective</h3><p>Investigating the optimal interstimulus interval (ISI) and the 24-hour test–retest reliability for intrahemispheric dorsal premotor cortex (PMd) – primary motor cortex (M1) connectivity using dual-site transcranial magnetic stimulation (dsTMS).</p></div><div><h3>Methods</h3><p>In 21 right-handed adults, left intrahemispheric PMd–M1 connectivity has been investigated with a stacked-coil dsTMS setup (conditioning stimulus: 75% of resting motor threshold; test stimulus: eliciting MEPs of 1–1.5 mV) at ISIs of 3, 5–8, and 10 ms. Additionally, M1–M1 short-interval intracortical inhibition (SICI) and intracortical facilitation (ICF) were investigated to assess comparability to standard paired-pulse setups.</p></div><div><h3>Results</h3><p>Conditioning PMd led to significant inhibition of M1 output at ISIs of 3 and 5 ms, whereas 10 ms resulted in facilitation (all, p < 0.001), with a fair test–retest reliability for 3 (ICC: 0.47) and 6 ms (ICC: 0.44) ISIs. Replication of SICI (p < 0.001) and ICF (p = 0.017) was successful, with excellent test–retest reliability for SICI (ICC: 0.81).</p></div><div><h3>Conclusion</h3><p>This dsTMS setup can probe the inhibitory and facilitatory PMd–M1 connections, as well as reliably replicate SICI and ICF paradigms.</p></div><div><h3>Significance</h3><p>The stacked-coil dsTMS setup for investigating intrahemispheric PMd–M1 connectivity offers promising possibilities to better understand motor control.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141497361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse 神经调节性经颅磁刺激（TMS）可改变功能连接，其改变程度与 TMS 脉冲诱导的电场成正比。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-19 DOI: 10.1016/j.clinph.2024.06.007

Nicholas L. Balderston , Romain J. Duprat , Hannah Long, Morgan Scully, Joseph A. Deluisi, Almaris Figueroa-Gonzalez, Marta Teferi, Yvette I. Sheline, Desmond J. Oathes

{"title":"Neuromodulatory transcranial magnetic stimulation (TMS) changes functional connectivity proportional to the electric-field induced by the TMS pulse","authors":"Nicholas L. Balderston , Romain J. Duprat , Hannah Long, Morgan Scully, Joseph A. Deluisi, Almaris Figueroa-Gonzalez, Marta Teferi, Yvette I. Sheline, Desmond J. Oathes","doi":"10.1016/j.clinph.2024.06.007","DOIUrl":"10.1016/j.clinph.2024.06.007","url":null,"abstract":"<div><h3>Objective</h3><p>Transcranial magnetic stimulation (TMS) can efficiently and robustly modulate synaptic plasticity, but little is known about how TMS affects functional connectivity (rs-fMRI). Accordingly, this project characterized TMS-induced rsFC changes in depressed patients who received 3 days of left prefrontal intermittent theta burst stimulation (iTBS).</p></div><div><h3>Methods</h3><p>rs-fMRI was collected from 16 subjects before and after iTBS. Correlation matrices were constructed from the cleaned rs-fMRI data. Electric-field models were conducted and used to predict pre-post changes in rs-fMRI. Site by orientation heatmaps were created for vectors centered on the stimulation site and a control site (contralateral motor cortex).</p></div><div><h3>Results</h3><p>For the stimulation site, there was a clear relationship between both site and coil orientation, and connectivity changes. As distance from the stimulation site increased, prediction accuracy decreased. Similarly, as eccentricity from the optimal orientation increased, prediction accuracy decreased. The systematic effects described above were not apparent in the heatmap centered on the control site.</p></div><div><h3>Conclusions</h3><p>These results suggest that rs-fMRI following iTBS changes systematically as a function of the distribution of electrical energy delivered from the TMS pulse, as represented by the e-field model.</p></div><div><h3>Significance</h3><p>This finding lays the groundwork for future studies to individualize TMS targeting based on how predicted rs-fMRI changes might impact psychiatric symptoms.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001809/pdfft?md5=4b13ac20103c55eb506363d1c0f79f72&pid=1-s2.0-S1388245724001809-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Should rTMS be considered a first-line treatment for major depressive episodes in adults? 经颅磁刺激疗法是否应被视为成人重度抑郁发作的一线治疗方法？

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-19 DOI: 10.1016/j.clinph.2024.06.004

Sean J. O’Sullivan , Derrick M. Buchanan , Jean-Marie V. Batail , Nolan R. Williams

{"title":"Should rTMS be considered a first-line treatment for major depressive episodes in adults?","authors":"Sean J. O’Sullivan , Derrick M. Buchanan , Jean-Marie V. Batail , Nolan R. Williams","doi":"10.1016/j.clinph.2024.06.004","DOIUrl":"10.1016/j.clinph.2024.06.004","url":null,"abstract":"<div><p>Treatment-resistant depression (TRD) is an epidemic with rising social, economic, and political costs. In a patient whose major depressive episode (MDE) persists through an adequate antidepressant trial, insurance companies often cover alternative treatments which may include repetitive transcranial magnetic stimulation (rTMS). RTMS is an FDA-cleared neuromodulation technique for TRD which is safe, efficacious, noninvasive, and well-tolerated. Recent developments in the optimization of rTMS algorithms and targeting have increased the efficacy of rTMS in treating depression, improved the clinical convenience of these treatments, and decreased the cost of a course of rTMS. In this opinion paper, we make a case for why conventional FDA-cleared rTMS should be considered as a first-line treatment for all adult MDEs. RTMS is compared to other first-line treatments including psychotherapy and SSRIs. These observations suggest that rTMS has similar efficacy, fewer side-effects, lower risk of serious adverse events, comparable compliance, the potential for more rapid relief, and cost-effectiveness. This suggestion, however, would be strengthened by further research with an emphasis on treatment-naive subjects in their first depressive episode, and trials directly contrasting rTMS with SSRIs or psychotherapy.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141537746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduced TMS-evoked EEG oscillatory activity in cortical motor regions in patients with post-COVID fatigue COVID 后疲劳患者皮层运动区的 TMS 诱发脑电图振荡活动减少。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-19 DOI: 10.1016/j.clinph.2024.06.008

Elias P. Casula , Romina Esposito , Sabrina Dezi , Paola Ortelli , Luca Sebastianelli , Davide Ferrazzoli , Leopold Saltuari , Valentina Pezzopane , Ilaria Borghi , Lorenzo Rocchi , Valentina Ajello , Eugen Trinka , Antonio Oliviero , Giacomo Koch , Viviana Versace

{"title":"Reduced TMS-evoked EEG oscillatory activity in cortical motor regions in patients with post-COVID fatigue","authors":"Elias P. Casula , Romina Esposito , Sabrina Dezi , Paola Ortelli , Luca Sebastianelli , Davide Ferrazzoli , Leopold Saltuari , Valentina Pezzopane , Ilaria Borghi , Lorenzo Rocchi , Valentina Ajello , Eugen Trinka , Antonio Oliviero , Giacomo Koch , Viviana Versace","doi":"10.1016/j.clinph.2024.06.008","DOIUrl":"10.1016/j.clinph.2024.06.008","url":null,"abstract":"<div><h3>Objective</h3><p>Persistent fatigue is a major symptom of the so-called ’long-COVID syndrome’, but the pathophysiological processes that cause it remain unclear.</p><p>We hypothesized that fatigue after COVID-19 would be associated with altered cortical activity in premotor and motor regions.</p></div><div><h3>Methods</h3><p>We used transcranial magnetic stimulation combined with EEG (TMS-EEG) to explore the neural oscillatory activity of the left primary motor area (l-M1) and supplementary motor area (SMA) in a group of sixteen post-COVID patients complaining of lingering fatigue as compared to a sample of age-matched healthy controls. Perceived fatigue was assessed with the Fatigue Severity Scale (FSS) and Fatigue Rating Scale (FRS).</p></div><div><h3>Results</h3><p>Post-COVID patients showed a remarkable reduction of beta frequency in both areas. Correlation analysis exploring linear relation between neurophysiological and clinical measures revealed a significant inverse correlation between the individual level of beta oscillations evoked by TMS of SMA with the individual scores in the FRS (r(15) = -0.596; p = 0.012).</p></div><div><h3>Conclusions</h3><p>Post-COVID fatigue is associated with a reduction of TMS-evoked beta oscillatory activity in SMA.</p></div><div><h3>Significance</h3><p>TMS-EEG could be used to identify early alterations of cortical oscillatory activity that could be related to the COVID impact in central fatigue.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory brainstem response to paired clicks as a candidate marker of cochlear synaptopathy in humans 听觉脑干对配对点击的反应是人类耳蜗突触病的候选标记

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-15 DOI: 10.1016/j.clinph.2024.06.005

Haruna Fujihira , Shimpei Yamagishi , Shigeto Furukawa , Makio Kashino

{"title":"Auditory brainstem response to paired clicks as a candidate marker of cochlear synaptopathy in humans","authors":"Haruna Fujihira , Shimpei Yamagishi , Shigeto Furukawa , Makio Kashino","doi":"10.1016/j.clinph.2024.06.005","DOIUrl":"10.1016/j.clinph.2024.06.005","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate whether auditory brainstem response (ABR) using a paired-click stimulation paradigm could serve as a tool for detecting cochlear synaptopathy (CS).</p></div><div><h3>Methods</h3><p>The ABRs to single-clicks and paired-clicks with various inter-click intervals (ICIs) and scores for word intelligibility in degraded listening conditions were obtained from 57 adults with normal hearing. The wave I peak amplitude and root mean square values for the post-wave I response within a range delayed from the wave I peak (referred to as the RMS<sub>post-w1</sub>) were calculated for the single- and second-click responses.</p></div><div><h3>Results</h3><p>The wave I peak amplitudes did not correlate with age except for the second-click responses at an ICI of 7 ms, and the word intelligibility scores. However, we found that the RMS<sub>post-w1</sub> values for the second-click responses significantly decreased with increasing age. Moreover, the RMS<sub>post-w1</sub> values for the second-click responses at an ICI of 5 ms correlated significantly with the scores for word intelligibility in degraded listening conditions.</p></div><div><h3>Conclusions</h3><p>The magnitude of the post-wave I response for the second-click response could serve as a tool for detecting CS in humans.</p></div><div><h3>Significance</h3><p>Our findings shed new light on the analytical methods of ABR for quantifying CS.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001779/pdfft?md5=5e7a428c91b1b250d1def22d11412b02&pid=1-s2.0-S1388245724001779-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141393406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical asymmetry in Parkinson’s disease is characterized by prevalence of subthalamic pause-burst neurons and alpha-beta oscillations 帕金森病的临床不对称性以丘脑下暂停-爆发神经元和阿尔法-贝塔振荡的流行为特征

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-14 DOI: 10.1016/j.clinph.2024.06.003

Philip Pavlovsky , Ksenia Sayfulina , Anna Gamaleya , Alexey Tomskiy , Elena Belova , Alexey Sedov

{"title":"Clinical asymmetry in Parkinson’s disease is characterized by prevalence of subthalamic pause-burst neurons and alpha-beta oscillations","authors":"Philip Pavlovsky , Ksenia Sayfulina , Anna Gamaleya , Alexey Tomskiy , Elena Belova , Alexey Sedov","doi":"10.1016/j.clinph.2024.06.003","DOIUrl":"10.1016/j.clinph.2024.06.003","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to establish specific biomarkers of Parkinson’s disease (PD) by comparing activity of more affected (MA) and less affected (LA) subthalamic nucleus (STN) of patients with prominent clinical asymmetry.</p></div><div><h3>Methods</h3><p>We recorded single unit activity and local field potentials (LFP) of the STN during deep brain stimulation surgeries. Neuronal firing patterns and discharge rate, as well as oscillatory features of both single cells and LFP, were analyzed.</p></div><div><h3>Results</h3><p>We observed notable differences in proportions of irregular-burst and pause-burst, but not tonic neurons, between the hemispheres. Oscillations of pause-burst neurons correlated significantly with the bradykinesia and rigidity scores of the corresponding hemibody. LFP derived from MA STN featured greater power in 12–15 Hz.</p></div><div><h3>Conclusions</h3><p>Our results provide evidence that the increased proportion of units with prolonged pauses may be associated with PD. We also speculate that some of them may gain rhythmicity in the alpha-beta range in relation to hypokinetic symptoms, long-term disease, or both.</p></div><div><h3>Significance</h3><p>Our findings highlight the relation between specific oscillatory features of the STN, predominance of subthalamic pause-burst units and PD pathophysiology.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141392916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson’s disease 在帕金森病患者中使用全植入式 DBS 系统进行神经反馈式 beta 功率控制。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-13 DOI: 10.1016/j.clinph.2024.06.001

Manabu Rohr-Fukuma , Lennart H. Stieglitz , Bartosz Bujan , Piotr Jedrysiak , Markus F. Oertel , Lena Salzmann , Christian R. Baumann , Lukas L. Imbach , Roger Gassert , Oliver Bichsel

{"title":"Neurofeedback-enabled beta power control with a fully implanted DBS system in patients with Parkinson’s disease","authors":"Manabu Rohr-Fukuma , Lennart H. Stieglitz , Bartosz Bujan , Piotr Jedrysiak , Markus F. Oertel , Lena Salzmann , Christian R. Baumann , Lukas L. Imbach , Roger Gassert , Oliver Bichsel","doi":"10.1016/j.clinph.2024.06.001","DOIUrl":"10.1016/j.clinph.2024.06.001","url":null,"abstract":"<div><h3>Objective</h3><p>Parkinsonian motor symptoms are linked to pathologically increased beta oscillations in the basal ganglia. Studies with externalised deep brain stimulation electrodes showed that Parkinson patients were able to rapidly gain control over these pathological basal ganglia signals through neurofeedback. Studies with fully implanted deep brain stimulation systems duplicating these promising results are required to grant transferability to daily application.</p></div><div><h3>Methods</h3><p>In this study, seven patients with idiopathic Parkinson’s disease and one with familial Parkinson’s disease were included. In a postoperative setting, beta oscillations from the subthalamic nucleus were recorded with a fully implanted deep brain stimulation system and converted to a real-time visual feedback signal. Participants were instructed to perform bidirectional neurofeedback tasks with the aim to modulate these oscillations.</p></div><div><h3>Results</h3><p>While receiving regular medication and deep brain stimulation, participants were able to significantly improve their neurofeedback ability and achieved a significant decrease of subthalamic beta power (median reduction of 31% in the final neurofeedback block).</p></div><div><h3>Conclusion</h3><p>We could demonstrate that a fully implanted deep brain stimulation system can provide visual neurofeedback enabling patients with Parkinson’s disease to rapidly control pathological subthalamic beta oscillations.</p></div><div><h3>Significance</h3><p>Fully-implanted DBS electrode-guided neurofeedback is feasible and can now be explored over extended timespans.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001743/pdfft?md5=603dd7e83a1b169564ab0c0100d1a54d&pid=1-s2.0-S1388245724001743-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141466761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Subthalamic DBS does not restore deficits in corticospinal suppression during movement preparation in Parkinson’s disease 丘脑下部脑电切除术不能恢复帕金森病患者运动准备过程中的皮质脊髓抑制缺陷

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-10 DOI: 10.1016/j.clinph.2024.06.002

Emmanuelle Wilhelm , Gerard Derosiere , Caroline Quoilin , Inci Cakiroglu , Susana Paço , Christian Raftopoulos , Bart Nuttin , Julie Duque

{"title":"Subthalamic DBS does not restore deficits in corticospinal suppression during movement preparation in Parkinson’s disease","authors":"Emmanuelle Wilhelm , Gerard Derosiere , Caroline Quoilin , Inci Cakiroglu , Susana Paço , Christian Raftopoulos , Bart Nuttin , Julie Duque","doi":"10.1016/j.clinph.2024.06.002","DOIUrl":"10.1016/j.clinph.2024.06.002","url":null,"abstract":"<div><h3>Objective</h3><p>Parkinson’s disease (PD) patients exhibit changes in mechanisms underlying movement preparation, particularly the suppression of corticospinal excitability – termed “preparatory suppression” – which is thought to facilitate movement execution in healthy individuals. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) being an attractive treatment for advanced PD, we aimed to study the potential contribution of this nucleus to PD-related changes in such corticospinal dynamics.</p></div><div><h3>Methods</h3><p>On two consecutive days, we applied single-pulse transcranial magnetic stimulation to the primary motor cortex of 20 advanced PD patients treated with bilateral STN-DBS (ON vs. OFF), as well as 20 healthy control subjects. Motor-evoked potentials (MEPs) were elicited at rest or during movement preparation in an instructed-delay choice reaction time task including left- or right-hand responses. Preparatory suppression was assessed by expressing MEPs during movement preparation relative to rest.</p></div><div><h3>Results</h3><p>PD patients exhibited a deficit in preparatory suppression when it was probed on the responding hand side, particularly when this corresponded to their most-affected hand, regardless of their STN-DBS status.</p></div><div><h3>Conclusions</h3><p>Advanced PD patients displayed a reduction in preparatory suppression which was not restored by STN-DBS.</p></div><div><h3>Significance</h3><p>The current findings confirm that PD patients lack preparatory suppression, as previously reported. Yet, the fact that this deficit was not responsive to STN-DBS calls for future studies on the neural source of this regulatory mechanism during movement preparation.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141390708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

No add-on therapeutic benefit of at-home anodal tDCS of the primary motor cortex to mindfulness meditation in patients with fibromyalgia 对纤维肌痛患者而言，在正念冥想的基础上对初级运动皮层进行居家阳极tDCS治疗没有附加疗效

IF 4.7 3区医学

Clinical Neurophysiology Pub Date : 2024-06-10 DOI: 10.1016/j.clinph.2024.05.018

Perianen Ramasawmy , Olga Lucía Gamboa Arana , Thuy Tien Mai , Luise Charlotte Heim , Samuel Enrico Schumann , Elisabeth Fechner , Yong Jiang , Oscar Moschner , Ivan Chakalov , Mathias Bähr , Frank Petzke , Andrea Antal

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