Clinical Neurophysiology最新文献_第10页

EEG in the critical care setting 脑电图在重症监护环境

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1016/j.clinph.2025.2111431

Lawrence J. Hirsch , Margaret T. Gopaul

{"title":"EEG in the critical care setting","authors":"Lawrence J. Hirsch , Margaret T. Gopaul","doi":"10.1016/j.clinph.2025.2111431","DOIUrl":"10.1016/j.clinph.2025.2111431","url":null,"abstract":"<div><div>Continuous EEG (cEEG) is increasingly used in the intensive care unit (ICU), but implementation and interpretation remain variable. To better understand its clinical impact, this review evaluates its role in diagnosis, prognostication, and treatment. To do so, we conducted a narrative review of observational studies, randomized controlled trials, consensus recommendations, and illustrative cases across adult and pediatric critical care populations. In these studies, nonconvulsive seizures occur in ∼10–20 % of ICU patients undergoing cEEG, most without clinical signs, and risk is highest in coma, pediatrics, with prior clinical seizures (recent or remote), and acute structural brain injury. Seizure burden > 12 min/hour (20 % burden) qualifies as status epilepticus (SE). Furthermore, higher seizure burden consistently predicts poor outcomes, including hippocampal injury, functional and cognitive impairment, epilepsy, and increased mortality. Additionally, rapid-response EEG and AI-based tools improve diagnostic efficiency, expand access, and may improve outcomes and length of stay. Quantitative EEG can reliably detect other acute brain events, such as delayed cerebral ischemia after subarachnoid hemorrhage, usually sooner than any other practical method. In summary, cEEG has transformed seizure detection and outcome prediction in the ICU, though gaps persist in access, workforce capacity, interpretation, patient selection, and clinical implementation. Broader standardization, expansion of point-of-care rapid EEG devices, and AI integration are critical to scaling cEEG and improving patient outcomes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111431"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Modulating altered sensory prediction using bilateral auditory cortex high-definition transcranial random noise stimulation and acoustic masking 利用双侧听觉皮层高清晰度经颅随机噪声刺激和声掩蔽调节改变的感觉预测。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-16 DOI: 10.1016/j.clinph.2025.2111388

Zino H. Wellauer , Deniza Avdi , Payam S. Shabestari , Allegra Preisig , Jessica Fritzsche , Nicole Peter , Martin Meyer , Tobias Kleinjung , Patrick K.A. Neff

{"title":"Modulating altered sensory prediction using bilateral auditory cortex high-definition transcranial random noise stimulation and acoustic masking","authors":"Zino H. Wellauer , Deniza Avdi , Payam S. Shabestari , Allegra Preisig , Jessica Fritzsche , Nicole Peter , Martin Meyer , Tobias Kleinjung , Patrick K.A. Neff","doi":"10.1016/j.clinph.2025.2111388","DOIUrl":"10.1016/j.clinph.2025.2111388","url":null,"abstract":"<div><h3>Objective:</h3><div>To assess the combined effect of high-definition transcranial random noise stimulation (HD-tRNS) of bilateral auditory cortex and acoustic stimulation (AS) on auditory evoked potentials and tinnitus perception.</div></div><div><h3>Methods:</h3><div>A double-blind, randomized, controlled, within-subject crossover trial was conducted with thirteen adults with chronic tinnitus. Each participant completed four sessions, at least 48 h apart, consisting of active HD-tRNS + AS, active HD-tRNS alone, sham HD-tRNS + sham AS and sham HD-tRNS alone. Auditory evoked potentials (including mismatch negativity) and tinnitus characteristics were measured before and after each session.</div></div><div><h3>Results:</h3><div>Active electric and bimodal stimulation significantly modulated auditory evoked potentials, unlike their sham equivalents. Bimodal stimulation produced significant changes in MMN amplitude that countered the tinnitus-related alteration in processing intensity deviants. However, these effects did not survive family-wise correction in this complex design. Bimodal and bimodal-sham stimulation reduced objective loudness by >3 dB.</div></div><div><h3>Conclusion:</h3><div>HD-tRNS, particularly when combined with AS, may induce changes in auditory-system excitability and acutely alter neural processing and loudness perception in tinnitus.</div></div><div><h3>Significance:</h3><div>Combining acoustic and electric stimulation is a promising approach for basic research and clinical applications in auditory neuroscience, providing new insights into neuroplasticity in an altered auditory system. This is the first study to measure the modifiability of evoked neural correlates in tinnitus.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111388"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Youth with essential tremor differ from age-matched controls in multiple aspects of visually-guided reaching movements 患有特发性震颤的青少年在视觉引导的伸手动作的多个方面与年龄匹配的对照组不同

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-19 DOI: 10.1016/j.clinph.2025.2111445

Nicholas Cothros , Catherine Lowrey , Stephen H. Scott , Alex Medina Escobar , Sean Dukelow , Davide Martino , Tamara Pringsheim

{"title":"Youth with essential tremor differ from age-matched controls in multiple aspects of visually-guided reaching movements","authors":"Nicholas Cothros , Catherine Lowrey , Stephen H. Scott , Alex Medina Escobar , Sean Dukelow , Davide Martino , Tamara Pringsheim","doi":"10.1016/j.clinph.2025.2111445","DOIUrl":"10.1016/j.clinph.2025.2111445","url":null,"abstract":"<div><h3>Objective</h3><div>Essential tremor (ET) likely includes deficits outside tremor, though this is under-examined in youth. We tested the hypothesis that reaching movements in youth with ET are characterized by greater incoordination.</div></div><div><h3>Methods</h3><div>Fifteen youth with ET (ages 11 to 17) recruited from the Calgary Tourette and Pediatric Movement Disorders Clinic completed a visually-guided reaching task using the Kinarm Exoskeleton Lab. Performance in several kinematic parameters was compared with age-matched controls.</div></div><div><h3>Results</h3><div>Youth with ET differed from controls in multiple parameters. In the dominant arm, the initial portion of reaching movements was slower and smaller-amplitude, with longer reaction time and greater posture speed at movement end when the hand should be at rest. In the non-dominant arm, those with ET differed from controls in a larger number of parameters. All but three with ET were impaired in at least one task parameter, scoring outside age-predicted norms.</div></div><div><h3>Conclusion</h3><div>Our study supports the notion of ET as a disorder with abnormalities beyond tremor, and that motoric abnormalities are demonstrable in youth with ET.</div></div><div><h3>Significance</h3><div>This is the first study showing youth with ET differ from age-matched controls in multiple aspects of reaching movements, including initial trajectory control, movement smoothness, overall trajectory, and endpoint control.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111445"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fiber recruitment in intra-epidermal electrical stimulation: Assessing the likelihood of Aδ- and Aβ-fiber activation 表皮内电刺激中的纤维募集：评估Aδ-和a β-纤维激活的可能性

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/j.clinph.2025.2111415

Sara U. Júlio , Jana Vaterlaus , Robin Lütolf , Markus Kofler , Michèle Hubli , Martin Schubert

{"title":"Fiber recruitment in intra-epidermal electrical stimulation: Assessing the likelihood of Aδ- and Aβ-fiber activation","authors":"Sara U. Júlio , Jana Vaterlaus , Robin Lütolf , Markus Kofler , Michèle Hubli , Martin Schubert","doi":"10.1016/j.clinph.2025.2111415","DOIUrl":"10.1016/j.clinph.2025.2111415","url":null,"abstract":"<div><h3>Objective</h3><div>To compare intra-epidermal (IES) and transcutaneous (TES) electrical stimulation with regard to nociceptive Aδ-fiber activation and Aβ-fiber co-activation. Cutaneous silent periods (CSPs) were assessed as a proxy for Aδ-fiber activation, and cortical vertex potentials (VPs) in the absence of somatosensory evoked cortical potentials (SSEPs) were assessed to exclude Aβ-fiber activation.</div></div><div><h3>Methods</h3><div>IES and TES were applied at increasing intensities (multiples of electrical detection threshold, EDT). In Experiment 1, psychophysical assessments, i.e., pain intensity and quality, and CSPs were compared for IES and TES at the index finger in 29 participants (10 m, 26.6 ± 3.5 years). In Experiment 2, SSEPs and VPs were compared for IES and TES over the superficial radial nerve in 28 participants (11 m, 26.6 ± 3.4 years).</div></div><div><h3>Results</h3><div>IES, irrespective of stimulation intensity, was mainly perceived as noxious and significantly more painful than TES (p < 0.001). Significant EMG suppression (p = 0.002) indicated robust CSPs following IES, suggesting efficient Aδ-fiber activation compared to TES at 4x EDT. Moreover, SSEPs were absent in response to IES at 4x EDT, suggesting low Aβ-fiber co-activation, while VPs were consistently detected.</div></div><div><h3>Conclusions</h3><div>IES at 4x EDT produces efficient Aδ-fiber activation with minimal Aβ-fiber co-activation, accompanied by consistently detected VPs.</div></div><div><h3>Significance</h3><div>IES at 4x EDT is suggested for efficient electrical nociceptive testing.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111415"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145518386","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of resting motor threshold availability on preoperative motor cortex localization using navigated-TMS in glioma surgery 脑胶质瘤手术中静息运动阈值可用性对术前运动皮质定位的影响。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-09 DOI: 10.1016/j.clinph.2025.2111429

Buntou Ro , Manabu Tamura , Atsushi Kuwano , Tomokazu Takakura , Sachiko Kodera , Akimasa Hirata , Takakazu Kawamata , Ken Masamune , Yoshihiro Muragaki

{"title":"Effect of resting motor threshold availability on preoperative motor cortex localization using navigated-TMS in glioma surgery","authors":"Buntou Ro , Manabu Tamura , Atsushi Kuwano , Tomokazu Takakura , Sachiko Kodera , Akimasa Hirata , Takakazu Kawamata , Ken Masamune , Yoshihiro Muragaki","doi":"10.1016/j.clinph.2025.2111429","DOIUrl":"10.1016/j.clinph.2025.2111429","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the concordance between preoperative motor cortex mapping using navigated transcranial magnetic stimulation (nTMS) and intraoperative direct electrical stimulation (DES), and to determine whether the ability to obtain the resting motor threshold (RMT) affects mapping accuracy.</div></div><div><h3>Methods</h3><div>Seventeen patients with motor or premotor cortical gliomas underwent preoperative nTMS and intraoperative DES. Motor mapping was performed using the RMT or, if unobtainable, the active motor threshold (AMT). Concordance between nTMS and DES was analyzed using Fisher’s exact test.</div></div><div><h3>Results</h3><div>Spatial concordance between nTMS and DES was observed in 9 of 12 patients (75 %) with measurable RMT. None of the five AMT-only cases demonstrated concordance. The difference in concordance rates between RMT and AMT-only cases was statistically significant (<em>p</em> = 0.026). Representative cases illustrate the relationship between RMT availability and mapping accuracy.</div></div><div><h3>Conclusions</h3><div>Preoperative nTMS mapping showed high concordance with DES when the RMT was obtainable. The lack of an RMT may predict reduced intraoperative mapping reliability.</div></div><div><h3>Significance</h3><div>RMT preoperative assessment can guide surgical planning, including the need for subcortical mapping or adjusted resection margins. These findings highlight the utility of nTMS for motor localization and emphasize the value of the RMT for predicting intraoperative mapping success.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111429"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3: An electric field modelling study 经颅直流电刺激治疗脊髓小脑共济失调3型：电场模拟研究。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-10-26 DOI: 10.1016/j.clinph.2025.2111405

Roderick P.P.W.M. Maas , ESMI MR Study Group , Jennifer Faber , Bart P.C. van de Warrenburg , Dennis J.L.G. Schutter

{"title":"Cerebellar transcranial direct current stimulation in spinocerebellar ataxia type 3: An electric field modelling study","authors":"Roderick P.P.W.M. Maas , ESMI MR Study Group , Jennifer Faber , Bart P.C. van de Warrenburg , Dennis J.L.G. Schutter","doi":"10.1016/j.clinph.2025.2111405","DOIUrl":"10.1016/j.clinph.2025.2111405","url":null,"abstract":"<div><h3>Objectives</h3><div>To compare cerebellar transcranial direct current stimulation (tDCS)-induced electric field strengths between individuals with spinocerebellar ataxia type 3 (SCA3) and healthy controls and to identify factors that underlie the variability in field strength.</div></div><div><h3>Methods</h3><div>MRI scans from 68 SCA3 mutation carriers spanning the disease spectrum and 37 healthy adults were used to reconstruct tetrahedral volume meshes of the head. Electric field simulations of midline cerebellar tDCS were performed with the buccinator muscle, frontopolar region, and lower neck as reference electrode positions. Eight regions of interest were defined throughout the cerebellum.</div></div><div><h3>Results</h3><div>Simulated electric field strengths induced by cerebellar tDCS were generally lower in SCA3 mutation carriers than in healthy controls, particularly in the anterior lobe and with cephalic reference electrodes. The frontopolar montage induced the highest field strengths, while the lower neck montage caused the lowest field strengths. Skin-cerebellum distance, Scale for the Assessment and Rating of Ataxia (SARA) score, and “occipital angle” were independently associated with electric field strength.</div></div><div><h3>Conclusion</h3><div>Skin-cerebellum distance, posterior fossa morphometry, ataxia severity, and electrode montage predict cerebellar tDCS-induced electric field strength in SCA3 mutation carriers. These results may guide the development of personalized neuromodulation protocols and inform the design of future cerebellar tDCS trials in degenerative ataxias.</div></div><div><h3>Significance</h3><div>This study identified clinical and anatomical factors that affect cerebellar tDCS-induced field strength in individuals with the most common type of dominantly inherited ataxia worldwide.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111405"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145494872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Does the ability to stop ongoing movement differentiate cervical dystonia from functional cervical dystonia? 停止正在进行的运动的能力能否区分颈张力障碍和功能性颈张力障碍？

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-04 DOI: 10.1016/j.clinph.2025.2111417

Sattwika Banerjee , Supriyo Choudhury , Asit Baran Bayen , Suchismita Majumdar , Akash Roy , Praveen Kumar , Souvik Chakroborty , Soumava Mukherjee , Jacky Ganguly , Purba Basu , Mark R Baker , Stuart N Baker , Hrishikesh Kumar

{"title":"Does the ability to stop ongoing movement differentiate cervical dystonia from functional cervical dystonia?","authors":"Sattwika Banerjee , Supriyo Choudhury , Asit Baran Bayen , Suchismita Majumdar , Akash Roy , Praveen Kumar , Souvik Chakroborty , Soumava Mukherjee , Jacky Ganguly , Purba Basu , Mark R Baker , Stuart N Baker , Hrishikesh Kumar","doi":"10.1016/j.clinph.2025.2111417","DOIUrl":"10.1016/j.clinph.2025.2111417","url":null,"abstract":"<div><h3>Objective</h3><div>Functional Cervical Dystonia (FCD) is characterized by hyperkinetic movements resembling Cervical Dystonia (CD). Previous studies report impaired reactive inhibition in CD, reflected by prolonged optimum combination Stop Signal Reaction Time (ocSSRT). This study compared ocSSRT in FCD, CD, and healthy controls.</div></div><div><h3>Methods</h3><div>20 CD and 14 FCD patients were recruited along with 23 age-matched healthy controls. All participants used a battery-operated portable device that measured both median reaction time and ocSSRT. Subjects released a button following a GO (green) signal and attempted to abort the movement when a STOP (red) signal followed the GO cue after a short delay.</div></div><div><h3>Results</h3><div>CD patients had significantly prolonged ocSSRT compared to FCD and healthy controls (CD: 373 ± 76 ms, FCD: 285 ± 80 ms, healthy: 248 ± 64 ms; CD vs FCD, p = 0.026; CD vs healthy, p < 0.001). No significant difference was found between FCD and healthy controls (p = 0.396). Median reaction time was significantly longer in CD (563 ± 117 ms) than healthy controls (466 ± 82 ms; p = 0.015), but not FCD (500 ± 117 ms; p = 0.296). The ROC curve AUC for ocSSRT distinguishing CD from FCD was 0.775 (p = 0.002).</div></div><div><h3>Conclusion and Significance</h3><div>ocSSRT may serve as a useful marker to differentiate CD from FCD in clinical settings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111417"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145562656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Automated estimation of EEG maturity in preterm neonates and its association with long-term outcome 早产儿脑电图成熟度的自动估计及其与长期预后的关系

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-11 DOI: 10.1016/j.clinph.2025.2111432

Johannes Mader , Manfred Hartmann , Katrin Klebermass-Schrehof , Tobias Werther , Anastasia Dressler , Lisa Oberdorfer , Nadine Pointner , Renate Fuiko , Angelika Berger , Tilmann Kluge , Vito Giordano

{"title":"Automated estimation of EEG maturity in preterm neonates and its association with long-term outcome","authors":"Johannes Mader , Manfred Hartmann , Katrin Klebermass-Schrehof , Tobias Werther , Anastasia Dressler , Lisa Oberdorfer , Nadine Pointner , Renate Fuiko , Angelika Berger , Tilmann Kluge , Vito Giordano","doi":"10.1016/j.clinph.2025.2111432","DOIUrl":"10.1016/j.clinph.2025.2111432","url":null,"abstract":"<div><h3>Objective</h3><div>To develop convolutional neural network (CNN) models to estimate EEG maturational age (EMA) from EEG recorded via amplitude-integrated EEG monitors in preterm infants and evaluate its association with long-term neurodevelopmental outcomes.</div></div><div><h3>Methods</h3><div>Three CNN models were trained on EEG data recorded from aEEG monitors from 92 preterm infants (23–41 weeks postmenstrual age) without major neurological complications and with normal cognitive outcomes at 2 years. The best-performing model based on MAE was applied to a broader cohort of 148 infants to assess the relationship between predicted age difference (PAD = EMA – PMA) and neurodevelopmental outcome using the Bayley Scales of Infant and Toddler Development (BSID-III).</div></div><div><h3>Results</h3><div>The best models achieved 87 % and 84 % accuracy within ± 1 week of actual PMA and a mean absolute error of 0.63 and 0.55 weeks. Infants with severely abnormal cognitive outcomes had significantly lower PAD scores compared to those with normal outcomes (P < 0.001). PAD and MAE showed moderate predictive value (AUC 0.69 and 0.77, respectively).</div></div><div><h3>Conclusions</h3><div>CNN-based EMA estimation from EEG recorded via aEEG monitors is accurate and correlates with long-term cognitive outcomes in preterm infants.</div></div><div><h3>Significance</h3><div>This study demonstrates the clinical potential of automated EEG maturity tracking using EEG as a real-time biomarker for neurodevelopmental risk.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111432"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145518384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nerve ultrasound in asymptomatic hereditary transthyretin amyloidosis carriers 无症状遗传性甲状腺转蛋白淀粉样变携带者的神经超声检查

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/j.clinph.2025.2111446

Wilder-Smith E , Tournev I , Chamova T , Asenov O , Bohlhalter S , Antimov P , Mihaylova V

{"title":"Nerve ultrasound in asymptomatic hereditary transthyretin amyloidosis carriers","authors":"Wilder-Smith E , Tournev I , Chamova T , Asenov O , Bohlhalter S , Antimov P , Mihaylova V","doi":"10.1016/j.clinph.2025.2111446","DOIUrl":"10.1016/j.clinph.2025.2111446","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of our study was to perform high-resolution nerve ultrasound in asymptomatic carriers of transthyretin (<em>TTR</em>) p.Glu89Gln (p.Glu109Gln) mutation and to evaluate its role as a complementary non-invasive diagnostic tool in early detection of amyloid deposits in peripheral nerves.</div></div><div><h3>Methods</h3><div>The study included 21 asymptomatic carriers of <em>TTR</em> p.Glu89Gln (p.Glu109Gln). History, neurological examination, nerve conduction studies, sympathetic skin response, SudoScan and high-resolution nerve ultrasound were performed.</div></div><div><h3>Results</h3><div>Ultrasound pattern sum score was abnormal in 70% of the carriers. Despite the younger age of male carriers compared to the female carriers the abnormal ultrasound findings were more frequently encountered in males. The latter also demonstrated more pronounced cross-sectional area enlargement of the peroneal nerve at the fibular head and had more frequently ultrasound evidence of median nerve swelling at the wrist. Sural nerves were not enlarged in contrast to radial and fibular superficial nerves which showed male preponderance.</div></div><div><h3>Conclusions</h3><div>Our data suggest early ultrasound detection of amyloid deposition in presymptomatic <em>TTR</em> p. Glu89Gln (p.Glu109Gln) carriers and demonstrated sex related differences with earlier amyloid deposition in male carriers.</div></div><div><h3>Significance</h3><div>As a non-invasive tool nerve ultrasound may be added to the established follow up program for the asymptomatic <em>TTR</em> carriers.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111446"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obituary 讣告。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/j.clinph.2025.2111441

引用次数: 0