Clinical Neurophysiology最新文献_第9页

Unraveling the neurophysiological intricacies of stuttering through sensorimotor oscillations 通过感觉运动振荡揭示口吃的神经生理学奥秘

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-01 DOI: 10.1016/j.clinph.2024.11.005

Ryouhei Ishii , Masaya Ueda

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Optimizing the identification of long-interval intracortical inhibition from the dorsolateral prefrontal cortex 优化背外侧前额叶皮层对长间隔皮层内抑制的识别。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-01 DOI: 10.1016/j.clinph.2024.10.018

Mayuko Takano , Masataka Wada , Shinichiro Nakajima , Keita Taniguchi , Shiori Honda , Yu Mimura , Ryosuke Kitahata , Reza Zomorrodi , Daniel M. Blumberger , Zafiris J. Daskalakis , Hiroyuki Uchida , Masaru Mimura , Yoshihiro Noda

{"title":"Optimizing the identification of long-interval intracortical inhibition from the dorsolateral prefrontal cortex","authors":"Mayuko Takano , Masataka Wada , Shinichiro Nakajima , Keita Taniguchi , Shiori Honda , Yu Mimura , Ryosuke Kitahata , Reza Zomorrodi , Daniel M. Blumberger , Zafiris J. Daskalakis , Hiroyuki Uchida , Masaru Mimura , Yoshihiro Noda","doi":"10.1016/j.clinph.2024.10.018","DOIUrl":"10.1016/j.clinph.2024.10.018","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to optimally evaluate the effect of the long-interval intracortical inhibition (LICI) in the dorsolateral prefrontal cortex (DLPFC) through transcranial magnetic stimulation combined with electroencephalography (TMS-EEG) by eliminating the volume conductance with signal source estimation and using a realistic sham coil as a control.</div></div><div><h3>Methods</h3><div>We compared the LICI effects from the DLPFC between the active and sham stimulation conditions in 27 healthy participants. Evoked responses between the two conditions were evaluated at the sensor and source levels.</div></div><div><h3>Results</h3><div>At the sensor level, a significant LICI effect was confirmed in the active condition in the global mean field power analysis; however, in the local mean field power analysis focused on the DLPFC, no LICI effect was observed in the active condition. However, in the signal source estimation analysis for the DLPFC, we could reconfirm a significant LICI effect (p = 0.023) in the interval 30–250 ms post-stimulus, compared to the sham condition.</div></div><div><h3>Conclusions</h3><div>Our results demonstrate that application of realistic sham stimulation condition and source estimation method allows for a robust and optimal identification of the LICI effect in the DLPFC.</div></div><div><h3>Significance</h3><div>The optimal DLPFC-LICI effect was identified by the use of the sophisticated sham coil.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 102-113"},"PeriodicalIF":3.7,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reply to “intraoperative corticobulbar motor evoked potentials and blink reflex during skull base surgery: Significance of anesthetic Regime” 对 "颅底手术中术中皮质束巴运动诱发电位和眨眼反射：麻醉制度的意义"。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 DOI: 10.1016/j.clinph.2024.10.009

Jiajia Liu , Xing Fan , Lirui Yang, Xiaorong Tao, Yanwen Jin, Ke Li, Jun Yang, Hui Qiao

引用次数: 0

Association of abnormal cortical inhibition and clinical outcomes in patients at clinical high risk for psychosis 异常皮质抑制与临床精神病高危患者临床预后的关系

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 DOI: 10.1016/j.clinph.2024.11.015

Guanfu Wu , Tianyuan Zhu , Chunyan Ma , Lihua Xu , Zhenying Qian , Gai Kong , Huiru Cui , Tianhong Zhang , Jijun Wang , Yingying Tang

{"title":"Association of abnormal cortical inhibition and clinical outcomes in patients at clinical high risk for psychosis","authors":"Guanfu Wu , Tianyuan Zhu , Chunyan Ma , Lihua Xu , Zhenying Qian , Gai Kong , Huiru Cui , Tianhong Zhang , Jijun Wang , Yingying Tang","doi":"10.1016/j.clinph.2024.11.015","DOIUrl":"10.1016/j.clinph.2024.11.015","url":null,"abstract":"<div><h3>Objective</h3><div>Cortical inhibition (CI) can be in-vivo measured using transcranial magnetic stimulation (TMS), and patients with schizophrenia had abnormal CI. However, whether the abnormal CI occur early in patients with clinical high risk for psychosis (CHR) or could predict their clinical outcomes remains less known.</div></div><div><h3>Methods</h3><div>We measured short-interval cortical inhibition (SICI), cortical silent period (CSP), and intra-cortical facilitation (ICF) over the motor cortex and neurocognitive performances in 55 CHR, 35 first-episode schizophrenia (FES), and 35 healthy controls (HC). We divided CHR patients into CHR converters (CHR-C) and CHR non-converters (CHR-NC) according to their clinical outcomes within the two-year follow-up.</div></div><div><h3>Results</h3><div>CSP was longer in CHR-C (P = 0.033) and FES (P = 0.047) than in HC, while CSP was comparable between CHR-NC and HC. In CHR, CSP was negatively related to their performances in symbol coding and maze tasks. There was no significant between-group difference for either SICI or ICF.</div></div><div><h3>Conclusions</h3><div>Our findings suggested GABA<sub>B</sub>-mediated CSP was prolonged in CHR, who later converted into schizophrenia, and was associated with poor neurocognitive functions.</div></div><div><h3>Significance</h3><div>CSP is prolonged before the onset of psychosis, particularly in CHR-C patients, suggesting that CSP could be a potential biomarker for predicting transition to schizophrenia.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 65-73"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The part and the whole: how single nodes contribute to large-scale phase-locking in functional EEG networks 部分与整体：单个节点如何促进功能性脑电图网络中的大规模相位锁定。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 DOI: 10.1016/j.clinph.2024.09.008

Anaïs Espinoso , Marc G. Leguia , Christian Rummel , Kaspar Schindler , Ralph G. Andrzejak

{"title":"The part and the whole: how single nodes contribute to large-scale phase-locking in functional EEG networks","authors":"Anaïs Espinoso , Marc G. Leguia , Christian Rummel , Kaspar Schindler , Ralph G. Andrzejak","doi":"10.1016/j.clinph.2024.09.008","DOIUrl":"10.1016/j.clinph.2024.09.008","url":null,"abstract":"<div><h3><strong>Objective</strong></h3><div>The application of signal analysis techniques to electroencephalographic (EEG) recordings from epilepsy patients shows that epilepsy involves not only altered neuronal synchronization but also the reorganization of functional EEG networks. This study aims to assess the large-scale phase-locking of such functional networks and how individual network nodes contribute to this collective dynamics.</div></div><div><h3><strong>Methods</strong></h3><div>We analyze the EEG recorded before, during and after seizures from sixteen patients with pharmacoresistant focal-onset epilepsy. The data is filtered to low (4–30 Hz) and high (80–150 Hz) frequencies. We define the multivariate phase-locking measure and the univariate phase-locking contribution measure. Surrogate signals are used to estimate baseline results expected under the null hypothesis that the EEG is a correlated linear stochastic process.</div></div><div><h3><strong>Results</strong></h3><div>On average, nodes from inside and outside the seizure onset zone (SOZ) increase and decrease, respectively, the large-scale phase-locking. This difference becomes most evident in a joint analysis of low and high frequencies.</div></div><div><h3><strong>Conclusions</strong></h3><div>Nodes inside and outside the SOZ play opposite roles for the large-scale phase-locking in functional EEG network in epilepsy patients.</div></div><div><h3><strong>Significance</strong></h3><div>The application of the phase-locking contribution measure to EEG recordings from epilepsy patients can potentially help in localizing the SOZ.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 178-192"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The seizure onset zone: More than just the “onset” zone 癫痫发作区：不仅仅是 "发作 "区

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 DOI: 10.1016/j.clinph.2024.10.002

Katherine A. Zarroli, Ramon Edmundo D. Bautista

引用次数: 0

Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects 揭示发育过程中隐藏的脑电图节律：健康受试者的非周期性和周期性活动

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-28 DOI: 10.1016/j.clinph.2024.11.014

Brenda Y. Angulo-Ruiz, Elena I. Rodríguez-Martínez, Vanesa Muñoz, Carlos M. Gómez

{"title":"Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects","authors":"Brenda Y. Angulo-Ruiz, Elena I. Rodríguez-Martínez, Vanesa Muñoz, Carlos M. Gómez","doi":"10.1016/j.clinph.2024.11.014","DOIUrl":"10.1016/j.clinph.2024.11.014","url":null,"abstract":"<div><h3>Objective</h3><div>The study analyzes power spectral density (PSD) components, aperiodic (AP) and periodic (P) activity, in resting-state EEG of 240 healthy subjects from 6 to 29 years old, divided into 4 groups.</div></div><div><h3>Methods</h3><div>We calculate AP and P components using the (<em>Fitting Oscillations and One-Over-f (FOOOF))</em> plugging in EEGLAB. All PSD components were calculated from 1-45 Hz. Topography analysis, Spearman correlations, and regression analysis with age were computed for all components.</div></div><div><h3>Results</h3><div>AP and P activity show different topography across frequencies and age groups. Age-related decreases in AP exponent and offset parameters lead to reduced power, while P power decreases (1–6 Hz) and increases (10–15 Hz) with age.</div></div><div><h3>Conclusions</h3><div>We support the distinction between the AP and P components of the PSD and its possible functional changes with age. AP power is dominant in the configuration of the canonical EEG rhythms topography, although P contribution to topography is embedded in the canonical EEG topography. Some EEG canonical characteristics are similar to those of the P component, as topographies of EEG rhythms (embedded) and increases in oscillatory frequency with age.</div></div><div><h3>Significance</h3><div>We support that spectral power parameterization improves the interpretation and neurophysiological and functional accuracy of brain processes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 53-64"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study 经皮耳迷走神经刺激（taVNS）对人胆碱能神经网络的影响：一项神经生理学研究

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-26 DOI: 10.1016/j.clinph.2024.11.012

Fioravante Capone, Francesco Motolese, Alessandro Cruciani, Mariagrazia Rossi, Gabriella Musumeci, Davide Norata, Massimo Marano, Fabio Pilato, Vincenzo Di Lazzaro

{"title":"The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study","authors":"Fioravante Capone, Francesco Motolese, Alessandro Cruciani, Mariagrazia Rossi, Gabriella Musumeci, Davide Norata, Massimo Marano, Fabio Pilato, Vincenzo Di Lazzaro","doi":"10.1016/j.clinph.2024.11.012","DOIUrl":"10.1016/j.clinph.2024.11.012","url":null,"abstract":"<div><h3>Objective</h3><div>The mechanisms of actions of transcutaneous auricular vagus nerve stimulation (taVNS) are still unclear, however the activity of the cholinergic system seems to be critical for the induction of VNS-mediated plasticity. Transcranial Magnetic Stimulation (TMS) is a well-suited, non-invasive tool to investigate cortical microcircuits involving different neurotransmitters. Herein, we evaluated the effect of taVNS on short-latency afferent inhibition (SAI), a TMS paradigm specifically measuring cholinergic neurotransmission.</div></div><div><h3>Methods</h3><div>Fifteen healthy subjects participated in this randomized placebo-controlled double-blind study. Each subject underwent two different sessions of 1-hour exposure to taVNS (real and sham) separated by a minimum of 48 h. Real taVNS was administered at left external acoustic meatus, while sham stimulation was performed at left ear lobe. We evaluated SAI bilaterally over the motor cortex before and after exposure to taVNS.</div></div><div><h3>Results</h3><div>No side effects were reported by any of the participants.</div><div>Statistical analysis did not show any significant effect of taVNS on SAI.</div></div><div><h3>Conclusions</h3><div>Our study demonstrated that cholinergic circuits explored by SAI are different from circuits engaged by taVNS.</div></div><div><h3>Significance</h3><div>Since the influence of VNS on cholinergic neurotransmission has been exhaustively demonstrated in animal models, further studies are mandatory to understand the actual impact of VNS on cholinergic circuits in humans.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 47-52"},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive muscle silent periods in acute post-anoxic brain injury: A novel phenotype of negative myoclonus 缺氧后急性脑损伤中的重复性肌肉沉默期：阴性肌阵挛的新表型

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.010

Saeideh Salehizadeh , Suhailah Hakami , Ramesh Shrestha , Neel Fotedar

{"title":"Repetitive muscle silent periods in acute post-anoxic brain injury: A novel phenotype of negative myoclonus","authors":"Saeideh Salehizadeh , Suhailah Hakami , Ramesh Shrestha , Neel Fotedar","doi":"10.1016/j.clinph.2024.11.010","DOIUrl":"10.1016/j.clinph.2024.11.010","url":null,"abstract":"<div><h3>Objective</h3><div>To report a novel phenotype of negative myoclonus in acute post-anoxic brain injury (PABI).</div></div><div><h3>Methods</h3><div>We performed a retrospective analysis of 18-channel video-EEG and surface-EMG (sEMG) recordings of three patients with PABI. sEMG electrodes were placed on the neck, bulbar and arm muscles.</div></div><div><h3>Results</h3><div>All three patients had whole body tonic posturing with intermittent brief relaxation<strong>.</strong> In patients #1 and #2, a generalized EEG burst-suppression was present. Repetitive silent periods (SPs) were noted in the sEMG channels, time-locked to EEG bursts. The bursts preceded the SPs by 135 ms and 124 ms, respectively. The average SP duration was 910 ms and 852 ms in patients #1 and 2, respectively. Patient #3 had a generalized background suppression pattern and average SP duration of 272.5 ms. The SP recruitment pattern in patient #1 was rostro-caudal whereas patient #3 had a variable recruitment pattern.</div></div><div><h3>Conclusion</h3><div>Acute post-anoxic negative myoclonus can be detected in comatose patients with sEMG electrodes. The muscle SPs produce intermittent relaxation of the tonic posturing. The putative generator can be cortical or reticular, similar to Lance-Adams syndrome.</div></div><div><h3>Significance</h3><div>We describe a novel phenotype of negative myoclonus in acute PABI. We also describe the EEG and sEMG characteristics and the localization of the putative generator.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 4-10"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia DLPFC上的双侧tDCS可增强气压感受器反射灵敏度并抑制与血压相关的低痛感

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.011

Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso

{"title":"Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia","authors":"Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso","doi":"10.1016/j.clinph.2024.11.011","DOIUrl":"10.1016/j.clinph.2024.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.</div></div><div><h3>Method</h3><div>Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.</div></div><div><h3>Results</h3><div>tDCS stimulation was followed by increases in BRS, pain intensity and unpleasantness. Anxiety decreased in the Sham group, but not in the tDCS group. Positive correlations between BP and pain threshold and tolerance before stimulation were observed. These remained during stimulation in the Sham group, but not in the tDCS group. Moreover, negative associations between BRS and BP only persisted in the Sham group.</div></div><div><h3>Discussion</h3><div>The results suggest that bilateral tDCS over the DLPFC enhances BRS and modulates pain perception and BP-related mechanisms. tDCS increases pain perception by inhibiting BP-related hypoalgesia and preventing habituation of anxiety.</div></div><div><h3>Significance</h3><div>Low BRS is a powerful prognostic factor of cardiovascular disease, such that its increase via tDCS may be a new therapeutic strategy for cardiovascular health promotion.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 11-22"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0