Clinical Neurophysiology最新文献

{"title":"EEG-based responses of patients with disorders of consciousness and healthy controls to familiar and non-familiar emotional videos","authors":"Anny Maza ,&nbsp;Sandra Goizueta ,&nbsp;María Dolores Navarro ,&nbsp;Enrique Noé ,&nbsp;Joan Ferri ,&nbsp;Valery Naranjo ,&nbsp;Roberto Llorens","doi":"10.1016/j.clinph.2024.10.010","DOIUrl":"10.1016/j.clinph.2024.10.010","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the differences in the brain responses of healthy controls (HC) and patients with disorders of consciousness (DOC) to familiar and non-familiar audiovisual stimuli and their consistency with the clinical progress.</div></div><div><h3>Methods</h3><div>EEG responses of 19 HC and 19 patients with DOC were recorded while watching emotionally-valenced familiar and non-familiar videos. Differential entropy of the EEG recordings was used to train machine learning models aimed to distinguish brain responses to stimuli type. The consistency of brain responses with the clinical progress of the patients was also evaluated.</div></div><div><h3>Results</h3><div>Models trained using data from HC outperformed those for patients. However, the performance of the models for patients was not influenced by their clinical condition. The models were successfully trained for over 75% of participants, regardless of their clinical condition. More than 75% of patients whose CRS-R scores increased post-study displayed distinguishable brain responses to both stimuli.</div></div><div><h3>Conclusions</h3><div>Responses to emotionally-valenced stimuli enabled modelling classifiers that were sensitive to the familiarity of the stimuli, regardless of the clinical condition of the participants and were consistent with their clinical progress in most cases.</div></div><div><h3>Significance</h3><div>EEG responses are sensitive to familiarity of emotionally-valenced stimuli in HC and patients with DOC.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 104-120"},"PeriodicalIF":3.7,"publicationDate":"2024-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142561143","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of cervical transcutaneous spinal direct current stimulation on spinal excitability","authors":"Luca Pierantoni ,&nbsp;Fabrizio Vecchio ,&nbsp;Francesca Miraglia ,&nbsp;Cristiano Pecchioli ,&nbsp;Francesco Iodice ,&nbsp;Claudia Carrarini ,&nbsp;Mattia Pinardi ,&nbsp;Giovanni Di Pino ,&nbsp;Silvestro Micera ,&nbsp;Paolo Maria Rossini","doi":"10.1016/j.clinph.2024.10.011","DOIUrl":"10.1016/j.clinph.2024.10.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of transcutaneous spinal direct current stimulation (tsDCS) on spinal cord excitability using neurophysiological methods.</div></div><div><h3>Methods</h3><div>Spinal cord motoneuron excitability was assessed using various neurophysiological techniques in a sham-controlled randomized experiment, which involved delivering 2 mA tsDCS and testing four different montages. Transcranial magnetic stimulation (TMS), F-waves to supramaximal ulnar nerve stimulation and somatosensory evoked potentials to upper limb nerves stimulation were measured in the participants with the electrode configuration that yielded the greatest effect, for a total of about 18 min. 18 young volunteers were recruited.</div></div><div><h3>Results</h3><div>Among the tested ones, the most promising tsDCS montage was the one with the anode placed on the 7th cervical spinous process and the cathode on the glottis. With this configuration, a significant enhancement of motor responses in the hand muscles to TMS of the contralateral hand motor area was observed during tsDCS (<span><math><mrow><mi>p</mi><mo>&lt;</mo><mn>0.00001</mn></mrow></math></span>), reaching a plateau after 6 min. This facilitation rapidly declined within a few minutes after the tsDCS was stopped.</div></div><div><h3>Conclusion</h3><div>Results of the different techniques suggest a possible contribution to facilitatory neuromodulation of the motoneurons at the cervical spine level.</div></div><div><h3>Significance</h3><div>The occurrence of enhanced excitability after tsDCS suggests potential application in individuals with partial corticospinal fiber impairment affecting hand motor function.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 95-103"},"PeriodicalIF":3.7,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142554613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Utility of CT perfusion in seizures and rhythmic and periodic patterns","authors":"Syed Ameen Ahmad ,&nbsp;Christopher Primiani ,&nbsp;Michael Porambo ,&nbsp;Tran Dang ,&nbsp;Peter W. Kaplan ,&nbsp;Vivek Yedavalli ,&nbsp;Khalil S. Husari","doi":"10.1016/j.clinph.2024.10.008","DOIUrl":"10.1016/j.clinph.2024.10.008","url":null,"abstract":"<div><h3>Objective</h3><div>CT hyper-perfusion has been reported in non-convulsive status epilepticus (NCSE), while its occurrence and relevance after single seizures or with rhythmic and periodic patterns (RPPs) that lie along the ictal-interictal continuum (IIC), remain unclear. The goal of the study is to assess the role of CT perfusion (CTP) in diagnosing patients with clinical seizures, subclinical seizures, or RPPs that lie along the IIC, to help in the clinical assessment of these entities.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed inpatients who underwent a CTP and an EEG within 6 h of each other. CTP and EEGs were blindly reviewed independent of electronic medical records.</div></div><div><h3>Results</h3><div>Out of 103 patients, 15 patients (15 %) demonstrated hyper-perfusion, 40 patients (39 %) had hypo-perfusion, while 48 patients (47 %) had normal CTP. Patients with focal CTP hyperperfusion were more likely to have clinical seizures, electrographic seizures, and/or lateralized rhythmic periodic patterns (RPPs) compared to those without CTP hyperperfusion<strong>.</strong> Focal CTP hyper-perfusion had 34 % sensitivity and 96 % specificity for identifying patients with clinical seizures, and a 40 % sensitivity and 92 % specificity for identifying patients with electrographic seizures or lateralized RPP. Although the numbers were small, none of the patients with generalized periodic discharges or generalized rhythmic delta activity had CTP hyper-perfusion.</div></div><div><h3>Conclusions</h3><div>Focal CTP hyper-perfusion has low sensitivity but high specificity for identifying patients with seizures and lateralized RPPs, and may be considered in the clinical assessment of patients where the clinical information are unclear or insufficient.</div></div><div><h3>Significance</h3><div>The presence of CTP hyper-perfusion should alert the physician to the possibility of an ictal related etiology accounting for the patient’s symptoms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 121-128"},"PeriodicalIF":3.7,"publicationDate":"2024-10-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567848","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Auditory gating and its clinical correlates in adults with chronic tic disorder and neurotypical adults","authors":"David A. Isaacs ,&nbsp;Andrew Xue ,&nbsp;Alexander C. Conley ,&nbsp;Alexandra P. Key","doi":"10.1016/j.clinph.2024.10.006","DOIUrl":"10.1016/j.clinph.2024.10.006","url":null,"abstract":"<div><h3>Background</h3><div>Over 80% of adults with chronic tic disorder (CTD) experience sensory over-responsivity (SOR), defined as heightened awareness of and/or behavioral reactivity to commonplace environmental stimuli. One potential mechanism underpinning SOR is sensory gating impairment. Sensory gating is the physiologic process whereby redundant stimuli are filtered out in early perceptual stages. In this study, we compared sensory gating between neurotypical and CTD adults and determined if gating indices associated with SOR.</div></div><div><h3>Methods</h3><div>Neurotypical (n = 31) and CTD adults (n = 26) completed a clinical assessment, including two SOR measures (Sensory Gating Inventory, SGI; Sensory Perception Quotient, SPQ), and an auditory gating paradigm while monitored on EEG.</div></div><div><h3>Results</h3><div>CTD adults exhibited greater SOR. Neurotypical and CTD adults did not differ in P50, N100, or P200 gating ratios. In regression analyses, N100 gating ratio was significantly associated with SGI score; the magnitude of this association was greater for neurotypical than CTD adults. No other significant associations emerged between gating ratios and SOR measures.</div></div><div><h3>Conclusion</h3><div>Findings do not support sensory gating impairment as a mechanism underpinning SOR in CTD.</div><div>The relationship between N100 gating and SOR warrants further investigation.</div></div><div><h3>Significance</h3><div>This is the first study to examine auditory gating in individuals with CTD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 72-82"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"fMRI neurofeedback for the modulation of the neural networks associated with depression","authors":"Ana Rita Barreiros ,&nbsp;Isabella B. Breukelaar ,&nbsp;Anthony W.F. Harris ,&nbsp;Mayuresh S. Korgaonkar","doi":"10.1016/j.clinph.2024.10.003","DOIUrl":"10.1016/j.clinph.2024.10.003","url":null,"abstract":"<div><h3>Objectives</h3><div>Functional magnetic resonance imaging (fMRI) neurofeedback has emerged as a potential treatment modality for depression, but little is known about its mechanism of action. This study aims to investigate the efficacy of fMRI neurofeedback in modulating neural networks in depression.</div></div><div><h3>Methods</h3><div>Following PRISMA guidelines, a systematic review was conducted focusing on fMRI neurofeedback interventions in depression. A comprehensive search across multiple databases yielded 16 eligible studies for review.</div></div><div><h3>Results</h3><div>The review demonstrated that fMRI neurofeedback can modulate BOLD activity even in strategy-free protocols and within a single session, with a significant learning effect evident over sessions. Neurofeedback targeting specific regions led to changes in connectivity across broad neural networks, including the default-mode and executive control networks, with effects being region-specific. However, methodological diversity and the absence of standardized protocols in the reviewed studies highlighted the need for more uniform research approaches.</div></div><div><h3>Conclusions</h3><div>fMRI neurofeedback shows promise as a modulatory technique for depression, with the potential to induce significant changes in neural activity and connectivity of networks implicated in depression.</div></div><div><h3>Significance</h3><div>The review underscores the necessity for standardized, reproducible neurofeedback protocols with control groups to enhance research comparability and generalizability.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 34-42"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal intraoperative neurophysiological monitoring may better predict postoperative distal upper extremities’ complex-functional outcome than spinal and muscular motor evoked potentials alone in high-cervical intramedullary spinal cord tumor surgery","authors":"Sebastian Siller ,&nbsp;Sylvain Duell ,&nbsp;Joerg-Christian Tonn ,&nbsp;Andrea Szelenyi","doi":"10.1016/j.clinph.2024.10.007","DOIUrl":"10.1016/j.clinph.2024.10.007","url":null,"abstract":"<div><h3>Objective</h3><div>D-wave can safely monitor the corticospinal-tract (CST)-function regarding gross-motor outcome of lower extremities, but it is still unknown whether i)D-wave can also safely monitor the gross-motor outcome of distal upper extremities in those patients undergoing high-cervical intramedullary-spinal-cord-tumor (IMSCT)-resection (enabling epidural D-wave-placement below C5) and ii)multimodal IONM can also predict fine-motor/complex hand function.</div></div><div><h3>Methods</h3><div>We prospectively assessed 20 patients undergoing IMSCT-surgery above the C4/5-level with multimodal IONM (D-wave/mMEPs/EMG/SSEPs). Detailed gross-/fine-motor and complex hand function was assessed pre- and postoperatively and during long-term follow-up (mean:29.5 ± 18.8 months) and correlated with IONM-findings.</div></div><div><h3>Results</h3><div>D-wave monitoring was without intraoperative critical changes in all patients and none had any permanent postoperative gross-motor deficits. However, D-wave did not allow to predict the occurrence of mild permanent postoperative deficits affecting fine-motor function which was the case in 8% for distal upper extremities. The complex distal upper extremities’ function assessed by Nine-Hole-Peg-Test (reflecting the complex motor/sensory interaction for hand-usability) was permanently deteriorated in 15% postoperatively and only the combination of D-wave/mMEPs/EMG/SSEPs was able to provide a viable predictive power (specificity:79%/sensitivity:43%).</div></div><div><h3>Conclusions</h3><div>In high-cervical IMSCT-surgery, unimpaired D-wave reliably predicts preserved gross-motor function, but fails to sufficiently cover distal upper extremities’ fine-motor/complex function.</div></div><div><h3>Significance</h3><div>Our study underlines the importance of multimodal IONM for fine-motor/complex hand function.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 52-60"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concurrent modulation of the brain-heart pathway: Unveiling potential antagonisms through transcranial magnetic stimulation and transcutaneous auricular vagus nerve stimulation integration","authors":"Mengnan Jia ,&nbsp;Yunyun Jiao ,&nbsp;Chen Cheng ,&nbsp;Xiaoyu Song ,&nbsp;Zhaoyang Chu ,&nbsp;Mengkai Zhang ,&nbsp;Jiajie Jin ,&nbsp;Xiao Zeng ,&nbsp;Jin-Bo Sun ,&nbsp;Wei Qin ,&nbsp;Xue-Juan Yang","doi":"10.1016/j.clinph.2024.10.005","DOIUrl":"10.1016/j.clinph.2024.10.005","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 1-3"},"PeriodicalIF":3.7,"publicationDate":"2024-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resting-state EEG spectral and fractal features in dementia with Lewy bodies with and without visual hallucinations","authors":"Antonino Vallesi ,&nbsp;Camillo Porcaro ,&nbsp;Antonino Visalli ,&nbsp;Davide Fasolato ,&nbsp;Francesco Rossato ,&nbsp;Cinzia Bussè ,&nbsp;Annachiara Cagnin","doi":"10.1016/j.clinph.2024.10.004","DOIUrl":"10.1016/j.clinph.2024.10.004","url":null,"abstract":"<div><h3>Objective</h3><div>Complex visual hallucinations (VH) are a core feature of dementia with Lewy bodies (DLB), though they may not occur in all patients. Power spectral density (PSD) analysis of resting-state EEG (rs-EEG) shows associations between some frequency bands (e.g., theta), individual alpha frequency (IAF) and VH. However, new tools that improve early differential diagnosis and symptom-based stratification with higher sensitivity and specificity, even within the DLB population, are desirable. We aimed to assess differences in rs-EEG data between DLB patients with VH (DLB-VH+) and without VH (DLB-VH-), comparing innovative non-linear approaches with more traditional linear ones.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed rs-EEG recordings of DLB-VH+, DLB-VH-, Alzheimer’s disease patients and age-matched healthy controls. EEG was analyzed using the nonlinear Higuchi’s Fractal Dimension (FD) measure, and the results were compared with those of entropy and standard linear methods based on PSD and IAF.</div></div><div><h3>Results</h3><div>Only the FD measure could discriminate between DLB-VH+ and DLB-VH-.</div></div><div><h3>Conclusions</h3><div>In conclusion, rs-EEG differences between DLB-VH+ and DLB-VH- are better characterized by FD analysis than by a more traditional power spectrum approach.</div></div><div><h3>Significance</h3><div>This suggests that the presence of complex VH is associated with less complex brain dynamics at rest, as reflected by the FD measure.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 43-51"},"PeriodicalIF":3.7,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intraoperative corticobulbar motor evoked potentials and blink reflex during skull base surgery: Significance of anesthetic regime","authors":"Isabel Fernández-Conejero,&nbsp;Júlia Miró-Lladó","doi":"10.1016/j.clinph.2024.10.001","DOIUrl":"10.1016/j.clinph.2024.10.001","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 61-62"},"PeriodicalIF":3.7,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496565","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-term motor learning in focal hand dystonia","authors":"Ejaz A. Shamim ,&nbsp;Min Seung Kim ,&nbsp;Suk Yun Kang ,&nbsp;Prachaya Srivanitchapoom ,&nbsp;Seung-Hyun Jin ,&nbsp;Elise Houdayer ,&nbsp;Pierre Diomi ,&nbsp;Nivethida Thirugnanasambandam ,&nbsp;Sahana N. Kukke ,&nbsp;Masao Matsuhashi ,&nbsp;Jean-Charles Lamy ,&nbsp;Tianxia Wu ,&nbsp;Sabine Meunier ,&nbsp;Mark Hallett","doi":"10.1016/j.clinph.2024.09.024","DOIUrl":"10.1016/j.clinph.2024.09.024","url":null,"abstract":"<div><h3>Objective</h3><div>Because focal hand dystonia usually occurs in the over-learned stage, it would be valuable to know long-term motor learning characteristics and underlying pathophysiological features that might predispose to dystonia.</div></div><div><h3>Methods</h3><div>We conducted a case-control exploratory study of 15 visits over 12 weeks in the non-affected hand of a 4-finger sequence of 8 key presses in eight patients with FHD compared with eight age- and sex-matched, healthy volunteers (HVs). We studied the behavioral data and the physiological changes of the brain, including motor cortical excitability and cortical oscillations.</div></div><div><h3>Results</h3><div>There was no significant difference in the time to reach 100 % accuracy between FHD and HV during the 80-day follow-up period. There was a statistically significant difference in the accuracy of sequential finger movement tasks between patients with FHD compared with HVs over 12 weeks, but post-hoc analysis with multiple comparion correction did not show difference. There were no significant differences in recruitment curve changes and task-related power changes of alpha and beta bands.</div></div><div><h3>Conclusion</h3><div>Over 12 weeks, FHD have motor learning capacity comparable to HVs and do not show pathophysiological abnormalities.</div></div><div><h3>Significance</h3><div>Further studies would be valuable with more patients, more extended periods of practice, and more detailed electrophysiological explorations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"168 ","pages":"Pages 63-71"},"PeriodicalIF":3.7,"publicationDate":"2024-10-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142533137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}