Clinical Neurophysiology最新文献

{"title":"Finding a new normal: Thalamic stereo EEG reveals physiological fast ripples","authors":"William C. Stacey","doi":"10.1016/j.clinph.2025.03.004","DOIUrl":"10.1016/j.clinph.2025.03.004","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 239-240"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of carpal tunnel syndrome using deep learning with comparative guidance","authors":"Jungsub Sim ,&nbsp;Sungche Lee ,&nbsp;Seunghyun Kim ,&nbsp;Seong-ho Jeong ,&nbsp;Joonshik Yoon ,&nbsp;Seungjun Baek","doi":"10.1016/j.clinph.2025.03.038","DOIUrl":"10.1016/j.clinph.2025.03.038","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop a deep learning model for a robust diagnosis of Carpal Tunnel Syndrome (CTS) based on comparative classification leveraging the ultrasound images of the thenar and hypothenar muscles.</div></div><div><h3>Methods</h3><div>We recruited 152 participants, both patients with varying severities of CTS and healthy individuals. The enrolled patients underwent ultrasonography, which provided ultrasound image data of the thenar and hypothenar muscles from the median and ulnar nerves. These images were used to train a deep learning model. We compared the performance of our model with previous comparative methods using echo intensity ratio or machine learning, and non-comparative methods based on deep learning. During the training process, comparative guidance based on cosine similarity was used so that the model learns to automatically identify the abnormal differences in echotexture between the ultrasound images of the thenar and hypothenar muscles.</div></div><div><h3>Results</h3><div>The proposed deep learning model with comparative guidance showed the highest performance. The comparison of Receiver operating characteristic (ROC) curves between models demonstrated that the Comparative guidance was effective in autonomously identifying complex features within the CTS dataset.</div></div><div><h3>Conclusions</h3><div>The proposed deep learning model with comparative guidance was shown to be effective in automatically identifying important features for CTS diagnosis from the ultrasound images. The proposed comparative approach was found to be robust to the traditional problems in ultrasound image analysis such as different cut-off values and anatomical variation of patients.</div></div><div><h3>Significance</h3><div>Proposed deep learning methodology facilitates accurate and efficient diagnosis of CTS from ultrasound images.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 191-197"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of functional and effective connectivity underlying auditory descriptive naming","authors":"Yu Kitazawa ,&nbsp;Kazuki Sakakura ,&nbsp;Hiroshi Uda ,&nbsp;Naoto Kuroda ,&nbsp;Riyo Ueda ,&nbsp;Ethan Firestone ,&nbsp;Min-Hee Lee ,&nbsp;Jeong-Won Jeong ,&nbsp;Masaki Sonoda ,&nbsp;Shin-ichiro Osawa ,&nbsp;Kazushi Ukishiro ,&nbsp;Makoto Ishida ,&nbsp;Kazuo Kakinuma ,&nbsp;Shoko Ota ,&nbsp;Yutaro Takayama ,&nbsp;Keiya Iijima ,&nbsp;Toshimune Kambara ,&nbsp;Hidenori Endo ,&nbsp;Kyoko Suzuki ,&nbsp;Nobukazu Nakasato ,&nbsp;Eishi Asano","doi":"10.1016/j.clinph.2025.04.008","DOIUrl":"10.1016/j.clinph.2025.04.008","url":null,"abstract":"<div><h3>Objective</h3><div>We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions.</div></div><div><h3>Methods</h3><div>We investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography.</div></div><div><h3>Results</h3><div>Hearing a <em>wh</em>-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with <em>what</em>, compared to <em>where</em>, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus.</div></div><div><h3>Conclusions</h3><div>Visualization of directional neural interactions within white matter networks during overt naming is feasible.</div></div><div><h3>Significance</h3><div>Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2010729"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DICOM encoding of annotation and montage data for waveform recordings","authors":"J.J. Halford ,&nbsp;B.A. Brinkmann ,&nbsp;S. Rampp ,&nbsp;J. Rémi ,&nbsp;S. Poznikoff ,&nbsp;K.B. Nilsen ,&nbsp;J.A. Ehrenberg ,&nbsp;S. Winkler","doi":"10.1016/j.clinph.2025.04.002","DOIUrl":"10.1016/j.clinph.2025.04.002","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 189-190"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic comparison of Commercial seizure detection Software: Update equals Upgrade?","authors":"Johannes Koren ,&nbsp;Kady Colabrese ,&nbsp;Manfred Hartmann ,&nbsp;Moritz Feigl ,&nbsp;Clemens Lang ,&nbsp;Sebastian Hafner ,&nbsp;Nicolas Nierenberg ,&nbsp;Tilmann Kluge ,&nbsp;Christoph Baumgartner","doi":"10.1016/j.clinph.2025.04.003","DOIUrl":"10.1016/j.clinph.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>To compare two updated commercially available seizure detection software packages (encevis 2.0 and Persyst 14) in a large video-EEG monitoring dataset comprising 80 patients with 6826 h of EEG and 912 seizures.</div></div><div><h3>Methods</h3><div>We conducted a follow up study of two seizure detection software packages with a significant update since 2021 using different sensitivity settings.</div></div><div><h3>Results</h3><div>Mean overall seizure count was 11.4 and mean tonic-clonic seizure rate was 0.7 per patient. Detection rates (DR) per patient were 80.7% to 89.1% for encevis 2.0 and 67.3% to 71.1% for Persyst 14. False positive rates (FPR) per day were 12 to 22 for encevis 2.0 and 2 to 4 for Persyst 14.</div></div><div><h3>Conclusions</h3><div>Encevis 2.0 showed a significantly higher DR than Persyst 14, whereas Persyst 14 showed a significantly lower FPR than encevis 2.0.</div></div><div><h3>Significance</h3><div>Updated FDA and CE certified seizure detection software showed opposite changes: encevis improved in sensitivity and deteriorated in FPR, while Persyst improved in FPR and deteriorated in sensitivity. In agreement with previous publications, automatic seizure detection software is ready for routine clinical use, but specialized personnel with sound neurophysiological knowledge and awareness of the strengths and weaknesses of the specific software package used is critical.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 178-188"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Correlates of taVNS: Scalp EEG and insular sEEG heartbeat evoked potentials modulation in an Epileptic patient case study","authors":"Enrique Germany Morrison ,&nbsp;Manon Dumoulin ,&nbsp;Vincent Joris ,&nbsp;Roberto Santalucia ,&nbsp;Venethia Danthine ,&nbsp;Inci Cakiroglu ,&nbsp;Giulia Liberati ,&nbsp;Antoine Nonclercq ,&nbsp;Riëm El Tahry","doi":"10.1016/j.clinph.2025.04.013","DOIUrl":"10.1016/j.clinph.2025.04.013","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 148-150"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing diagnostic sensitivity in Myasthenia Gravis: The combined role of CMAP area and amplitude decrements in repetitive nerve stimulation","authors":"Ângelo Fonseca ,&nbsp;Marco Almeida ,&nbsp;Cristina Duque ,&nbsp;Luís Negrão ,&nbsp;Anabela Matos ,&nbsp;Luciano Almendra","doi":"10.1016/j.clinph.2025.04.004","DOIUrl":"10.1016/j.clinph.2025.04.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the diagnostic utility of using CMAP area decrement, in addition to CMAP amplitude decrement, in RNS testing for patients with suspected MG.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed EMG data from January 2019 to December 2023 on patients with suspected MG. CMAP area and amplitude decrements of ≥10 % were considered abnormal, and MG diagnosis was based on clinical presentation, antibody testing, or response to treatment.</div></div><div><h3>Results</h3><div>A total of 204 patients were included in the final analysis. MG was diagnosed in 71 patients (29.8%). The sensitivity of the amplitude decrement was 29.6%, while the sensitivity of the area decrement was 38%, with specificities of 99.2% and 96.12%, respectively. Combining both criteria yielded a sensitivity of 43.7%, representing a 14.1% improvement over amplitude decrement alone.</div></div><div><h3>Conclusion</h3><div>Incorporating CMAP area decrement into RNS testing significantly enhances diagnostic sensitivity for MG, particularly in ocular forms, without compromising specificity. This combined approach presents a promising improvement over existing diagnostic tools for MG, especially in cases where traditional methods have limitations. Future research is needed to validate these findings.</div></div><div><h3>Significance</h3><div>This study introduces a practical and easy to adopt enhancement to repetitive nerve stimulation, significantly improving diagnostic sensitivity for Myasthenia Gravis.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 169-172"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single session of motor imagery paired with spinal stimulation improves manual dexterity and increases cortical excitability after spinal cord injury","authors":"Antonio Capozio ,&nbsp;Madison Graham ,&nbsp;Ronaldo Ichiyama ,&nbsp;Sarah L. Astill","doi":"10.1016/j.clinph.2025.03.047","DOIUrl":"10.1016/j.clinph.2025.03.047","url":null,"abstract":"<div><h3>Objective</h3><div>Non-invasive stimulation of the spinal cord at the cervical level (TSCS) can induce neural plasticity and improve upper limb function in people living with cervical spinal cord injury (SCI) when paired with task practice. The aim of this study was to investigate the effects of a session of motor imagery (MI) paired with TSCS on manual dexterity, corticospinal and spinal excitability in people living with cervical SCI.</div></div><div><h3>Methods</h3><div>Eight participants (4 females, mean age 46yrs ± 17) completed three sessions of: 1) MI; 2) TSCS at C5–C6 level; 3) MI + TSCS, listening to the MI script while receiving TSCS. Manual dexterity was assessed with the Purdue Pegboard Test (PPT), corticospinal excitability was assessed with Transcranial Magnetic Stimulation (TMS) delivered at motor threshold and suprathreshold (120 % intensities, and spinal excitability delivered at motor threshold and suprathreshold (110 %, 120 %) intensities was assessed with single pulses of TSCS.</div></div><div><h3>Results</h3><div>Manual dexterity increased from baseline after all three conditions (p = 0.016). Corticospinal excitability increased from baseline after MI (p = 0.002] and MI + TSCS (p = 0.031], but not TSCS (p = 0.343). Spinal excitability was not affected by any of the conditions (p = 0.425).</div></div><div><h3>Conclusions</h3><div>These findings demonstrate that a single session of MI and TSCS, either alone or in combination, can increase manual dexterity in people living with cervical SCI. The increase in dexterity was paralleled by increases in corticospinal excitability for the MI and MI + TSCS conditions.</div></div><div><h3>Significance</h3><div>Our findings indicate that MI and TSCS improve manual dexterity and increase corticospinal excitability in people living with cervical SCI when employed in isolation or in combination.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 160-168"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating muscle Artifact in TMS-EEG","authors":"Mohsen Poorganji,&nbsp;Zafiris J. Daskalakis","doi":"10.1016/j.clinph.2025.04.010","DOIUrl":"10.1016/j.clinph.2025.04.010","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 223-224"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the thalamocortical component of high frequency oscillations following botulinum toxin treatment in cervical dystonia.","authors":"Alessandro Cruciani, Gaia Anzini, Alessandro Magliozzi, Gabriella Musumeci, Daniel T Corp, Maria Concetta Altavista, Vincenzo Di Lazzaro, Massimo Marano","doi":"10.1016/j.clinph.2025.03.048","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.03.048","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the central effects of Botulinum toxin type A (BoNT-A) on the somatosensory system in patients with cervical dystonia (CD), focusing on the thalamocortical pathway using high-frequency oscillations (HFOs) and short-latency afferent inhibition (SAI).</p><p><strong>Methods: </strong>An observational longitudinal study was conducted on 10CD patients and 10 healthy controls (HC). HFOs and SAI were assessed for CD and HC at baseline (T0; the day before BoNT-A treatment). Then only for CD patients, SAI and HFOs were assessed again 30 days after (T1) BoNT-A treatment. Changes in SAI values and HFO early and late area between T0 and T1 in CD patients were evaluated with the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>At T0, CD patients exhibited significantly reduced early HFOs compared to HC, with no significant differences in late HFOs or SAI values. After BoNT-A treatment, a significant increase in early HFOs was observed in CD patients at T1, while late HFOs and SAI values remained unchanged.</p><p><strong>Conclusion: </strong>The findings suggest that BoNT-A treatment may have central effects on thalamocortical activity, as evidenced by changes of early HFOs in CD patients following injections.</p><p><strong>Significance: </strong>This study provides neurophysiological evidence supporting the central effects of BoNT-A on the somatosensory system and corroborates the idea of a somatosensory involvement in CD pathogenesis. This funding could pave the way for future integrated treatment approaches.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}