Clinical Neurophysiology最新文献

{"title":"Network excitability of stimulation-induced spectral responses helps localize the seizure onset zone","authors":"Mark A. Hays ,&nbsp;Amir H. Daraie ,&nbsp;Rachel J. Smith ,&nbsp;Sridevi V. Sarma ,&nbsp;Nathan E. Crone ,&nbsp;Joon Y. Kang","doi":"10.1016/j.clinph.2024.07.010","DOIUrl":"10.1016/j.clinph.2024.07.010","url":null,"abstract":"<div><h3>Objective</h3><p>While evoked potentials elicited by single pulse electrical stimulation (SPES) may assist seizure onset zone (SOZ) localization during intracranial EEG (iEEG) monitoring, induced high frequency activity has also shown promising utility. We aimed to predict SOZ sites using induced cortico-cortical spectral responses (CCSRs) as an index of excitability within epileptogenic networks.</p></div><div><h3>Methods</h3><p>SPES was conducted in 27 epilepsy patients undergoing iEEG monitoring and CCSRs were quantified by significant early (10–200 ms) increases in power from 10 to 250 Hz. Using response power as CCSR network connection strengths, graph centrality measures (metrics quantifying each site’s influence within the network) were used to predict whether sites were within the SOZ.</p></div><div><h3>Results</h3><p>Across patients with successful surgical outcomes, greater CCSR centrality predicted SOZ sites and SOZ sites targeted for surgical treatment with median AUCs of 0.85 and 0.91, respectively. We found that the alignment between predicted and targeted SOZ sites predicted surgical outcome with an AUC of 0.79.</p></div><div><h3>Conclusions</h3><p>These findings indicate that network analysis of CCSRs can be used to identify increased excitability of SOZ sites and discriminate important surgical targets within the SOZ.</p></div><div><h3>Significance</h3><p>CCSRs may supplement traditional passive iEEG monitoring in seizure localization, potentially reducing the need for recording numerous seizures.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141772544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Respiratory modulation of sleep oscillations: A new frontier in sleep research","authors":"Ahmad Mayeli,&nbsp;Fabio Ferrarelli","doi":"10.1016/j.clinph.2024.07.009","DOIUrl":"10.1016/j.clinph.2024.07.009","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141772545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel neurophysiological evidence for preserved pain habituation across chronic pain conditions","authors":"Iara De Schoenmacker ,&nbsp;David Costa Marques ,&nbsp;Paulina S. Scheuren ,&nbsp;Robin Lütolf ,&nbsp;Lindsay M. Gorrell ,&nbsp;Sarah C. Mehli ,&nbsp;Armin Curt ,&nbsp;Jan Rosner ,&nbsp;Michèle Hubli","doi":"10.1016/j.clinph.2024.07.007","DOIUrl":"10.1016/j.clinph.2024.07.007","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to investigate whether subjective and objective measures of pain habituation can be used as potential markers for central sensitization across various chronic pain patients.</p></div><div><h3>Methods</h3><p>Two blocks of contact-heat stimuli were applied to a non-painful area in 93 chronic pain patients (low back pain, neuropathic pain, and complex regional pain syndrome) and 60 healthy controls (HC). Habituation of pain ratings, contact-heat evoked potentials (CHEP), and sympathetic skin responses (SSR) was measured.</p></div><div><h3>Results</h3><p>There was no significant difference in any measure of pain habituation between patients and HC. Even patients with apparent clinical signs of central sensitization showed no reduced pain habituation. However, prolonged baseline CHEP and SSR latencies (stimulation block 1) were found in patients compared to HC (CHEP: Δ-latency = 23 ms, p = 0.012; SSR: Δ-latency = 100 ms, p = 0.022).</p></div><div><h3>Conclusion</h3><p>Given the performed multimodal neurophysiological testing protocol, we provide evidence indicating that pain habituation may be preserved in patients with chronic pain and thereby be of limited use as a sensitive marker for central sensitization. These results are discussed within the framework of the complex interactions between pro- and antinociceptive mechanism as well as methodological issues. The prolonged latencies of CHEP and SSR after stimulation in non-painful areas may indicate subclinical changes in the integrity of thermo-nociceptive afferents, or a shift towards antinociceptive activity. This shift could potentially affect the relay of ascending signals.</p></div><div><h3>Significance</h3><p>Our findings challenge the prevailing views in the literature and may encourage further investigations into the peripheral and central components of pain habituation, using advanced multimodal neurophysiological techniques.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002074/pdfft?md5=4f514cb4dbaa403c123197c4cbd2c044&pid=1-s2.0-S1388245724002074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to “TDCS for Parkinson’s disease-related pain: A randomized trial” [Clin. Neurophysiol. 161 (2024) 133-146]","authors":"Yeray González-Zamorano ,&nbsp;Francisco José Sánchez-Cuesta ,&nbsp;Marcos Moreno-Verdú ,&nbsp;Aida Arroyo-Ferrer ,&nbsp;Josué Fernández-Carnero ,&nbsp;K. Ray Chaudhuri ,&nbsp;Anna Fieldwalker ,&nbsp;Juan Pablo Romero","doi":"10.1016/j.clinph.2024.07.001","DOIUrl":"10.1016/j.clinph.2024.07.001","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001937/pdfft?md5=68e7d2bccd2e8fc776984d01f4e3d08e&pid=1-s2.0-S1388245724001937-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three montages for Transcranial electric stimulation in predicting the early post-surgery outcome of the facial nerve functioning.","authors":"Mikael Gian Andrea Izzo, Davide Rossi Sebastiano, Valentina Catanzaro, Ylenia Melillo, Ramona Togni, Elisa Visani, Jacopo Falco, Cecilia Casali, Marco Gemma, Paolo Ferroli, Annamaria Gallone, Daniele Cazzato, Grazia Devigili, Sara Alverà, Paola Lanteri","doi":"10.1016/j.clinph.2024.07.008","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.07.008","url":null,"abstract":"<p><strong>Objective: </strong>We assessed the Transcranial Electrical Stimulation (TES)-induced Corticobulbar-Motor Evoked Potentials (Cb-MEPs) evoked from Orbicularis Oculi (Oc) and Orbicularis Oris (Or) muscles with FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6/-Cz stimulation, during IntraOperative NeuroMonitoring (IONM) in 30 patients who underwent skull-base surgery.</p><p><strong>Methods: </strong>before (T0) and after (T1) the surgery, we compared the peak-to-peak amplitudes of Cb-MEPs obtained from TES with C3/C4-Cz, C5/C6-Cz and FCC5h/FCC6h-Mz. Then, we compared the response category (present, absent and peripheral) related to different montages. Finally, we classified the Cb-MEPs data from each patient for concordance with clinical outcome and we assessed the diagnostic measures for Cb-MEPs data obtained from FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6-Cz TES stimulation.</p><p><strong>Results: </strong>Both at T0 and T1, FCC5h/FCC6h-Mz stimulation evoked larger Cb-MEPs than C3/C4-Cz, less peripheral responses from direct activation of facial nerve than C5/C6-Cz. FCC5h/FCC6h-Mz stimulation showed the best accuracy and specificity of Cb-MEPs for clinical outcomes.</p><p><strong>Conclusions: </strong>FCC5h/FCC6h-Mz stimulation showed the best performances for monitoring the facial nerve functioning, maintaining excellent diagnostic measures even at low stimulus voltages.</p><p><strong>Significance: </strong>We demonstrated that FCC5h/FCC6h-Mz TES montage for Cb-MEPs in IONM has good accuracy in predicting the post-surgery outcome of facial nerve functioning.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Transcranial direct current stimulation improves tardive dyskinesia in long-term hospitalized patients with chronic schizophrenia","authors":"Xiaoli Lyu ,&nbsp;Zhe Li ,&nbsp;Siyu Chen ,&nbsp;Shuguang Gu ,&nbsp;Zhaoxin Zhou ,&nbsp;Ruchang Yang ,&nbsp;Ping Yang ,&nbsp;Guangya Zhang ,&nbsp;Chuanwei Li ,&nbsp;Nian Yuan ,&nbsp;Ming Yin ,&nbsp;Wenyue Zhang ,&nbsp;Xuexing Wei ,&nbsp;Xiaoxia Huang ,&nbsp;Xiangdong Du","doi":"10.1016/j.clinph.2024.07.006","DOIUrl":"10.1016/j.clinph.2024.07.006","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in chronic schizophrenia patients with tardive dyskinesia (TD) who were long-term hospitalized.</p></div><div><h3>Methods</h3><p>Sixty-four inpatients who met the DSM-IV diagnostic criteria for schizophrenia and TD were randomly assigned to either the active (N=35) or sham (N=29) group. Treatment was given 15 times, with each session lasting for 30 min, and an intensity of 2 mA. The anode was placed on the left dorsolateral prefrontal cortex and the cathode on the right supraorbital region. Primary outcome was measured by the changes in Abnormal Involuntary Movements Scale (AIMS) score. Secondary outcomes were measured using the Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Adverse effects of tDCS were assessed with an experimenter-administered open-ended questionnaire throughout the experiment.</p></div><div><h3>Results</h3><p>Of the 64 patients, 52 (81.25%) completed the study. Compared to the sham group, patients in the active group exhibited a significant reduction in both the total AIMS score and the facial-oral subscore (<em>P</em>&lt;0.05). An improvement of at least 30% in total AIMS scores was observed in the active group (14 patients, 50%) compared to the sham group (2 patients, 8.3%) after treatment (<em>P</em>&lt;0.01). There were no between-group differences in the PANSS and SANS total scores. However, there was a significant difference between the two groups in the occurrence of the reported adverse effect of tingling sensation (<em>P</em>&lt;0.05).</p></div><div><h3>Conclusions</h3><p>TDCS may be an effective and safe treatment for improving the facial-oral motor symptoms of TD in chronically hospitalized patients with schizophrenia.</p></div><div><h3>Significance</h3><p>This study provides a novel perspective for the clinical treatment of patients with TD.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sensory intelligence for extraction of abstract auditory rules from a speech sound stream in children with cochlear implants","authors":"Liu-Ting He,&nbsp;Xin-Ran Xu,&nbsp;Rui-Rui Guan,&nbsp;Wan Zhao,&nbsp;Jia-Qiang Sun,&nbsp;Jing-Wu Sun,&nbsp;Xiao-Tao Guo","doi":"10.1016/j.clinph.2024.07.005","DOIUrl":"10.1016/j.clinph.2024.07.005","url":null,"abstract":"<div><h3>Objective</h3><p>Sensory intelligence in the brain helps listeners automatically extract abstract auditory rules formed by invariant acoustic features from complex speech sound streams, presumably serving as the neural basis for speech comprehension. However, whether this intelligence is deficient in children with cochlear implants (CIs) remains unclear.</p></div><div><h3>Methods</h3><p>Mandarin Chinese monosyllables shared a flat lexical tone contour to form an abstract auditory rule but differed in other acoustic features to construct a complex speech sound stream. The abstract rule was occasionally violated by monosyllables with a rising or falling lexical tone.</p></div><div><h3>Results</h3><p>In normal hearing (NH) children, the abstract auditory rule could be extracted, as revealed by a mismatch negativity (MMN) and a late discriminative negativity (LDN). However, the MMN and LDN were only evoked in CI children with good hearing and speech performance. NH children with a higher speech perception or spatial hearing score had a greater MMN. The LDN was attenuated with increasing age in NH children.</p></div><div><h3>Conclusions</h3><p>The sensory intelligence for extraction of auditory abstract rules, associated with speech perception, is deficient in CI children. This intelligence may gradually develop during childhood and adolescence.</p></div><div><h3>Significance</h3><p>Deficient sensory intelligence in CI children may aid in understanding poor speech comprehension in complex environments.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathic phenotypes of type 1 diabetes are related to different signatures of magnetic resonance spectroscopy-assessed brain metabolites","authors":"Tine M. Hansen ,&nbsp;Suganthiya S. Croosu ,&nbsp;Johan Røikjer ,&nbsp;Carsten D. Mørch ,&nbsp;Niels Ejskjaer ,&nbsp;Jens B. Frøkjær","doi":"10.1016/j.clinph.2024.06.017","DOIUrl":"10.1016/j.clinph.2024.06.017","url":null,"abstract":"<div><h3>Objectives</h3><p>The study aimed to investigate brain metabolites in type 1 diabetes and the associations with disease characteristics. We explored the metabolic profiles predicting different neuropathic phenotypes using multiple linear regression analyses.</p></div><div><h3>Methods</h3><p>We compared brain metabolites in 55 adults with type 1 diabetes (including painful diabetic peripheral neuropathy (DPN), painless DPN, without DPN) with 20 healthy controls. Proton magnetic resonance spectroscopy measurements (N-acetylaspartate (NAA), glutamate (glu), myo-inositol (mI), and glycerophosphocholine (GPC) were obtained in ratios to creatine (cre)) from the parietal region, anterior cingulate cortex and thalamus.</p></div><div><h3>Results</h3><p>The overall diabetes group revealed decreased parietal NAA/cre compared to healthy controls (1.41 ± 0.12 vs. 1.55 ± 0.13,p &lt; 0.001) and increased mI/cre (parietal: 0.62 ± 0.08 vs. 0.57 ± 0.07,p = 0.025, cingulate: 0.65 ± 0.08 vs. 0.60 ± 0.08,p = 0.033). Reduced NAA/cre was associated with more severe DPN (all p ≤ 0.04) whereas increased mI/cre was associated with higher hemoglobin A_1c (HbA_1c) (p = 0.02). Diabetes was predicted from decreased parietal NAA/cre, increased parietal ml/cre, and decreased thalamic glu/cre. DPN was predicted from decreased parietal NAA/cre and increased GPC/cre. Painful DPN was predicted from increased parietal GPC/cre and thalamic glu/cre.</p></div><div><h3>Conclusions</h3><p>Specific metabolic brain profiles were linked to the different phenotypes of diabetes, DPN and painful DPN.</p></div><div><h3>Significance</h3><p>Assessment of metabolic profiles could be relevant for detailed understanding of central neuropathy in diabetes.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001998/pdfft?md5=4afcaedcf5c628ff9517025633e1175a&pid=1-s2.0-S1388245724001998-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141643659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stochastic resonance in the sensory systems and its applications in neural prosthetics","authors":"Patrick Matthews ,&nbsp;Pratik Raul ,&nbsp;Lawrence M. Ward ,&nbsp;Jeroen J.A. van Boxtel","doi":"10.1016/j.clinph.2024.07.004","DOIUrl":"10.1016/j.clinph.2024.07.004","url":null,"abstract":"<div><p>Noise is generally considered to be detrimental. In the right conditions, however, noise can improve signal detection or information transmission. This counterintuitive phenomenon is called stochastic resonance (SR). SR has generated significant interdisciplinary interest, particularly in physics, engineering, and medical and environmental sciences. In this review, we discuss a growing empirical literature that suggests that noise at the right intensity may improve the detection and processing of auditory, sensorimotor, and visual stimuli. We focus particularly on applications of SR in sensory biology and investigate whether SR-based technologies present a pathway to improve outcomes for individuals living with sensory impairments. We conclude that there is considerable evidence supporting the application of SR in developing sensory prosthetics. However, the progression of SR-based technologies is variable across the sensory modalities. We suggest opportunities for further advancements in each modality, considering the best approaches to maximise benefits and capitalise on progress already made. Overall, SR can offer opportunities to improve existing technologies or to motivate innovations.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002025/pdfft?md5=7d4f5e0bef81c2d2f8a4b36d9f25f132&pid=1-s2.0-S1388245724002025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The timing of sleep spindles is modulated by the respiratory cycle in humans","authors":"Valentin Ghibaudo ,&nbsp;Maxime Juventin ,&nbsp;Nathalie Buonviso ,&nbsp;Laure Peter-Derex","doi":"10.1016/j.clinph.2024.06.014","DOIUrl":"10.1016/j.clinph.2024.06.014","url":null,"abstract":"<div><h3>Objective</h3><p>Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In rodents, this respiratory drive strongly varies according to vigilance states. Whether sleep oscillations are also respiration-modulated in humans remains open. In this work, we investigated the influence of breathing on sleep spindles during non-rapid-eye-movement sleep in humans.</p></div><div><h3>Methods</h3><p>Full night polysomnography of twenty healthy participants were analysed. Spindles and slow waves were automatically detected during N2 and N3 stages. Spindle-related sigma power as well as spindle and slow wave events were analysed according to the respiratory phase.</p></div><div><h3>Results</h3><p>We found a significant coupling between both slow and fast spindles and the respiration cycle, with enhanced sigma activity and occurrence probability of spindles during the middle part of the expiration phase. A different coupling was observed for slow waves negative peaks which were rather distributed around the two respiration phase transitions.</p></div><div><h3>Conclusion</h3><p>Our findings suggest that breathing cycle influences the dynamics of brain activity during non-rapid-eye-movement sleep.</p></div><div><h3>Significance</h3><p>This coupling may enable sleep spindles to synchronize with other sleep oscillations and facilitate information transfer between distributed brain networks.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001962/pdfft?md5=f26fcc77bfaf95206abd1ab941254b2a&pid=1-s2.0-S1388245724001962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}