Clinical Neurophysiology最新文献

{"title":"DICOM encoding of annotation and montage data for waveform recordings","authors":"J.J. Halford , B.A. Brinkmann , S. Rampp , J. Rémi , S. Poznikoff , K.B. Nilsen , J.A. Ehrenberg , S. Winkler","doi":"10.1016/j.clinph.2025.04.002","DOIUrl":"10.1016/j.clinph.2025.04.002","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 189-190"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Systematic comparison of Commercial seizure detection Software: Update equals Upgrade?","authors":"Johannes Koren ,&nbsp;Kady Colabrese ,&nbsp;Manfred Hartmann ,&nbsp;Moritz Feigl ,&nbsp;Clemens Lang ,&nbsp;Sebastian Hafner ,&nbsp;Nicolas Nierenberg ,&nbsp;Tilmann Kluge ,&nbsp;Christoph Baumgartner","doi":"10.1016/j.clinph.2025.04.003","DOIUrl":"10.1016/j.clinph.2025.04.003","url":null,"abstract":"<div><h3>Objective</h3><div>To compare two updated commercially available seizure detection software packages (encevis 2.0 and Persyst 14) in a large video-EEG monitoring dataset comprising 80 patients with 6826 h of EEG and 912 seizures.</div></div><div><h3>Methods</h3><div>We conducted a follow up study of two seizure detection software packages with a significant update since 2021 using different sensitivity settings.</div></div><div><h3>Results</h3><div>Mean overall seizure count was 11.4 and mean tonic-clonic seizure rate was 0.7 per patient. Detection rates (DR) per patient were 80.7% to 89.1% for encevis 2.0 and 67.3% to 71.1% for Persyst 14. False positive rates (FPR) per day were 12 to 22 for encevis 2.0 and 2 to 4 for Persyst 14.</div></div><div><h3>Conclusions</h3><div>Encevis 2.0 showed a significantly higher DR than Persyst 14, whereas Persyst 14 showed a significantly lower FPR than encevis 2.0.</div></div><div><h3>Significance</h3><div>Updated FDA and CE certified seizure detection software showed opposite changes: encevis improved in sensitivity and deteriorated in FPR, while Persyst improved in FPR and deteriorated in sensitivity. In agreement with previous publications, automatic seizure detection software is ready for routine clinical use, but specialized personnel with sound neurophysiological knowledge and awareness of the strengths and weaknesses of the specific software package used is critical.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 178-188"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143869089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural Correlates of taVNS: Scalp EEG and insular sEEG heartbeat evoked potentials modulation in an Epileptic patient case study","authors":"Enrique Germany Morrison ,&nbsp;Manon Dumoulin ,&nbsp;Vincent Joris ,&nbsp;Roberto Santalucia ,&nbsp;Venethia Danthine ,&nbsp;Inci Cakiroglu ,&nbsp;Giulia Liberati ,&nbsp;Antoine Nonclercq ,&nbsp;Riëm El Tahry","doi":"10.1016/j.clinph.2025.04.013","DOIUrl":"10.1016/j.clinph.2025.04.013","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 148-150"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143859036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing diagnostic sensitivity in Myasthenia Gravis: The combined role of CMAP area and amplitude decrements in repetitive nerve stimulation","authors":"Ângelo Fonseca ,&nbsp;Marco Almeida ,&nbsp;Cristina Duque ,&nbsp;Luís Negrão ,&nbsp;Anabela Matos ,&nbsp;Luciano Almendra","doi":"10.1016/j.clinph.2025.04.004","DOIUrl":"10.1016/j.clinph.2025.04.004","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the diagnostic utility of using CMAP area decrement, in addition to CMAP amplitude decrement, in RNS testing for patients with suspected MG.</div></div><div><h3>Methods</h3><div>This retrospective study analyzed EMG data from January 2019 to December 2023 on patients with suspected MG. CMAP area and amplitude decrements of ≥10 % were considered abnormal, and MG diagnosis was based on clinical presentation, antibody testing, or response to treatment.</div></div><div><h3>Results</h3><div>A total of 204 patients were included in the final analysis. MG was diagnosed in 71 patients (29.8%). The sensitivity of the amplitude decrement was 29.6%, while the sensitivity of the area decrement was 38%, with specificities of 99.2% and 96.12%, respectively. Combining both criteria yielded a sensitivity of 43.7%, representing a 14.1% improvement over amplitude decrement alone.</div></div><div><h3>Conclusion</h3><div>Incorporating CMAP area decrement into RNS testing significantly enhances diagnostic sensitivity for MG, particularly in ocular forms, without compromising specificity. This combined approach presents a promising improvement over existing diagnostic tools for MG, especially in cases where traditional methods have limitations. Future research is needed to validate these findings.</div></div><div><h3>Significance</h3><div>This study introduces a practical and easy to adopt enhancement to repetitive nerve stimulation, significantly improving diagnostic sensitivity for Myasthenia Gravis.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 169-172"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A single session of motor imagery paired with spinal stimulation improves manual dexterity and increases cortical excitability after spinal cord injury","authors":"Antonio Capozio ,&nbsp;Madison Graham ,&nbsp;Ronaldo Ichiyama ,&nbsp;Sarah L. Astill","doi":"10.1016/j.clinph.2025.03.047","DOIUrl":"10.1016/j.clinph.2025.03.047","url":null,"abstract":"<div><h3>Objective</h3><div>Non-invasive stimulation of the spinal cord at the cervical level (TSCS) can induce neural plasticity and improve upper limb function in people living with cervical spinal cord injury (SCI) when paired with task practice. The aim of this study was to investigate the effects of a session of motor imagery (MI) paired with TSCS on manual dexterity, corticospinal and spinal excitability in people living with cervical SCI.</div></div><div><h3>Methods</h3><div>Eight participants (4 females, mean age 46yrs ± 17) completed three sessions of: 1) MI; 2) TSCS at C5–C6 level; 3) MI + TSCS, listening to the MI script while receiving TSCS. Manual dexterity was assessed with the Purdue Pegboard Test (PPT), corticospinal excitability was assessed with Transcranial Magnetic Stimulation (TMS) delivered at motor threshold and suprathreshold (120 % intensities, and spinal excitability delivered at motor threshold and suprathreshold (110 %, 120 %) intensities was assessed with single pulses of TSCS.</div></div><div><h3>Results</h3><div>Manual dexterity increased from baseline after all three conditions (p = 0.016). Corticospinal excitability increased from baseline after MI (p = 0.002] and MI + TSCS (p = 0.031], but not TSCS (p = 0.343). Spinal excitability was not affected by any of the conditions (p = 0.425).</div></div><div><h3>Conclusions</h3><div>These findings demonstrate that a single session of MI and TSCS, either alone or in combination, can increase manual dexterity in people living with cervical SCI. The increase in dexterity was paralleled by increases in corticospinal excitability for the MI and MI + TSCS conditions.</div></div><div><h3>Significance</h3><div>Our findings indicate that MI and TSCS improve manual dexterity and increase corticospinal excitability in people living with cervical SCI when employed in isolation or in combination.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 160-168"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143863949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitigating muscle Artifact in TMS-EEG","authors":"Mohsen Poorganji,&nbsp;Zafiris J. Daskalakis","doi":"10.1016/j.clinph.2025.04.010","DOIUrl":"10.1016/j.clinph.2025.04.010","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 223-224"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143978941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in the thalamocortical component of high frequency oscillations following botulinum toxin treatment in cervical dystonia.","authors":"Alessandro Cruciani, Gaia Anzini, Alessandro Magliozzi, Gabriella Musumeci, Daniel T Corp, Maria Concetta Altavista, Vincenzo Di Lazzaro, Massimo Marano","doi":"10.1016/j.clinph.2025.03.048","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.03.048","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the central effects of Botulinum toxin type A (BoNT-A) on the somatosensory system in patients with cervical dystonia (CD), focusing on the thalamocortical pathway using high-frequency oscillations (HFOs) and short-latency afferent inhibition (SAI).</p><p><strong>Methods: </strong>An observational longitudinal study was conducted on 10CD patients and 10 healthy controls (HC). HFOs and SAI were assessed for CD and HC at baseline (T0; the day before BoNT-A treatment). Then only for CD patients, SAI and HFOs were assessed again 30 days after (T1) BoNT-A treatment. Changes in SAI values and HFO early and late area between T0 and T1 in CD patients were evaluated with the Wilcoxon signed-rank test.</p><p><strong>Results: </strong>At T0, CD patients exhibited significantly reduced early HFOs compared to HC, with no significant differences in late HFOs or SAI values. After BoNT-A treatment, a significant increase in early HFOs was observed in CD patients at T1, while late HFOs and SAI values remained unchanged.</p><p><strong>Conclusion: </strong>The findings suggest that BoNT-A treatment may have central effects on thalamocortical activity, as evidenced by changes of early HFOs in CD patients following injections.</p><p><strong>Significance: </strong>This study provides neurophysiological evidence supporting the central effects of BoNT-A on the somatosensory system and corroborates the idea of a somatosensory involvement in CD pathogenesis. This funding could pave the way for future integrated treatment approaches.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered electroencephalography-based source functional connectivity in patients with generalized anxiety disorder","authors":"Che-Sheng Chu ,&nbsp;Yen-Yue Lin ,&nbsp;Cathy Chia-Yu Huang ,&nbsp;Yong-An Chung ,&nbsp;Sonya Youngju Park ,&nbsp;Wei-Chou Chang ,&nbsp;Chuan-Chia Chang ,&nbsp;Hsin-An Chang","doi":"10.1016/j.clinph.2025.04.014","DOIUrl":"10.1016/j.clinph.2025.04.014","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the neurophysiological markers of generalized anxiety disorder (GAD), we performed electroencephalography (EEG) in patients with GAD and assessed lagged phase synchronization (LPS), a measure of brain functional connectivity (FC).</div></div><div><h3>Methods</h3><div>Cortical EEG sources were modelled by exact low resolution brain electromagnetic tomography (eLORETA). Graph theory analyses were applied to undirected and weighted networks obtained by LPS to explore the FC differences between patients with GAD and controls. The association between the abnormal parameters and disease symptomatology was examined.</div></div><div><h3>Results</h3><div>Compared to controls (n = 89), the GAD group (n = 104) showed higher brain connectivity in beta-2 (18.5–21 Hz) between the left cingulate gyrus and the right postcentral gyrus (PcG) and in beta-3 (21.5–30 Hz) between the brain hemispheres in several regions, particularly the left PcG. Patients with GAD showed higher global network efficiency in beta-3. Finally, a positive correlation was observed between a longer duration of illness and greater FC in beta-2 between brain regions.</div></div><div><h3>Conclusions</h3><div>The present findings suggest that EEG-sourced measures are useful tools for understanding altered brain connectivity in GAD.</div></div><div><h3>Significance</h3><div>EEG could be a valuable biomarker in differentiating patients with GAD from controls and could be a potential predictive tool in future studies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2010736"},"PeriodicalIF":3.7,"publicationDate":"2025-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143895817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Video head impulse test findings in patients with peripheral myelin protein 22 related neuropathies","authors":"Zeljka Calic ,&nbsp;Bogdan Bjelica ,&nbsp;Stojan Peric ,&nbsp;Milorad Vujnic ,&nbsp;Ivo Bozovic ,&nbsp;Vidosava Rakocevic-Stojanovic ,&nbsp;Andrew Bradshaw ,&nbsp;Miriam S Welgampola","doi":"10.1016/j.clinph.2025.03.046","DOIUrl":"10.1016/j.clinph.2025.03.046","url":null,"abstract":"<div><h3>Objective</h3><div>Vestibular impairment may be present in and contribute to imbalance in patients with hereditary neuropathies. We examined the vestibulo-ocular reflex (VOR) characteristics in peripheral myelin protein 22 neuropathies using the video head-impulse test (vHIT).</div></div><div><h3>Methods</h3><div>23 patients with Charcot-Marie-Tooth disease 1A (CMT1A) and 17 with hereditary neuropathy with liability to pressure palsies (HNPP) were recruited. Three-dimensional vHIT was performed. VOR-gain and latency, refixation-saccade prevalence and first-saccade amplitude, onset-latency, peak-velocity and duration were examined and compared against age-matched controls.</div></div><div><h3>Results</h3><div>In CMT1A and HNPP gait imbalance was reported in 78.3 % and 58.8 % of patients, resulting in recurrent falls in 65.2 % and 23.5 %. Reduced VOR-gain affecting the posterior-canals (PCs) was found in 47.8 % of CMT1A and 11.7 % of HNPP patients. First saccade amplitude and peak-velocities higher in horizontal-canal (HC) and PC in the CMT1A group compared to controls (p &lt; 0.05). In HNPP, first saccades were larger in HC and anterior-canal (AC) planes; saccade peak-velocity was higher in AC and PC planes compared to controls (p &lt; 0.05). In CMT1A, VOR-gain impairment was associated with higher Charcot-Marie-Tooth Examination Score, longer disease duration, and higher total Overall Neuropathy Limitation Scale score (p &lt; 0.05) and VOR-gain was lower for PC in patients with a history of recurrent falls (p &lt; 0.05). VOR-latency was significantly longer in HC and PCs in CMT1A compared to controls (p &lt; 0.05).</div></div><div><h3>Conclusions</h3><div>VOR impairment and slowing of the VOR-latency is found in CMT1A but not the HNPP cohort. These findings may relate to demyelinating processes affecting the vestibular nerves and thus the VOR pathways. <em>Significance:</em> VHIT allows detection of VOR impairment which could be an additional contributor to imbalance and falls in patients with CMT1A.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2010721"},"PeriodicalIF":3.7,"publicationDate":"2025-04-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143906002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical plasticity, therapeutic effects, and neural circuit activity of angular gyrus rTMS in amnestic mild cognitive impairment","authors":"Ya Chen ,&nbsp;Xinle Hou ,&nbsp;Huijuan Zhou ,&nbsp;Tingyu Lv ,&nbsp;Ruichen Han ,&nbsp;Zhiyuan Yang ,&nbsp;Wenao Zheng ,&nbsp;Feng Bai","doi":"10.1016/j.clinph.2025.04.012","DOIUrl":"10.1016/j.clinph.2025.04.012","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to explore the neurophysiological mechanisms behind the improvement of cognitive functions through angular gyrus repetitive transcranial magnetic stimulation (rTMS) in patients with amnestic mild cognitive impairment (aMCI) by assessing cortical plasticity, underscoring the predictive value of cortical plasticity for clinical outcomes.</div></div><div><h3>Methods</h3><div>Twenty-seven aMCI patients were allocated to the intervention and control groups for 4 weeks of 20 Hz rTMS of the angular gyrus. Long-term potentiation (LTP)-like cortical plasticity in the motor M1 area, in conjunction with neuropsychological tests and resting-state brain imaging, was used to investigate the mechanism behind angular gyrus rTMS.</div></div><div><h3>Results</h3><div>At baseline, aMCI patients presented impaired LTP-like motor cortical plasticity related to cognitive damage. Following treatment with angular gyrus rTMS, a reversal in the impairment of this plasticity was observed. This improvement was associated with clinical efficacy in terms of cognitive function and changes in the resting-state brain network activities of the sensorimotor, default mode, and frontoparietal networks.</div></div><div><h3>Conclusions</h3><div>Clinical symptoms are alleviated by angular gyrus rTMS, and damaged cortex plasticity also shows signs of improvement, potentially linked to transcortical neural activity across multiple brain regions in aMCI patients. Cortical plasticity induced by transcranial magnetic stimulation has potential value in predicting the clinical outcomes of neuromodulation.</div></div><div><h3>Significance</h3><div>Motor cortex plasticity may be related to cognitive function and therapeutic effects in aMCI patients and may be modulated by angular gyrus transcranial magnetic stimulation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 198-211"},"PeriodicalIF":3.7,"publicationDate":"2025-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143881742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}