Clinical Neurophysiology最新文献

{"title":"Isolated hippocampal sclerosis and focal dysplasia type IIIa: Comparative study of anatomo-electro-clinical profile and seizure outcome","authors":"Mariem Ben Mahmoud ,&nbsp;Adrien Benard ,&nbsp;Delphine Taussig ,&nbsp;Pascale Trebon ,&nbsp;Dan Cristian Chiforeanu ,&nbsp;Yves Sahler ,&nbsp;Arnaud Biraben ,&nbsp;Anca Nica ,&nbsp;Mihai Dragos Maliia","doi":"10.1016/j.clinph.2025.2111461","DOIUrl":"10.1016/j.clinph.2025.2111461","url":null,"abstract":"<div><h3>Objective</h3><div>Distinguishing drug-resistant temporal lobe epilepsy (TLE) caused by isolated hippocampal sclerosis (iHS) from focal cortical dysplasia type IIIa (FCD IIIa) remains a presurgical challenge. This study aimed to compare the clinical characteristics, electrophysiological data, and postsurgical seizure outcomes between these pathologies.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed a cohort of 50 consecutive TLE patients (mean duration of disease of 22 years) who underwent surgery. The histopathology confirmed either iHS (n = 22) or FCD IIIa (n = 28) and a minimum follow-up of 12 months. The groups were compared on complex presurgical data, surgery type, and outcome.</div></div><div><h3>Results</h3><div>A history of febrile seizures (p = 0.02, OR = 4.7) was more frequent in the FCD IIIa group, which also had significantly lower intelligence quotient (IQ) scores in all domains. The mean total IQ score for FCD IIIa/iHS was 86/94 (p = 0.02); verbal IQ was 85/92 (p = 0.03); performance IQ was 89/98 (p = 0.02). The effect size was considered medium for all three (Cohen’s <em>d =</em> 0.7, 0.63 and 0.68 respectively<em>).</em> Scalp EEG showed shorter seizures in FCD IIIa (p = 0.03), in SEEG, the temporal pole was more implanted in this group (p = 0.02, 50 % difference, OR = ∞). At a mean follow-up of 8.5 years, similar seizure-freedom rates was found between groups (82 % for FCD IIIa, 95 % for iHS; p = 0.48). Follow-up EEG and neuropsychological assessment at 6 months post-surgery showed no statistical differences.</div></div><div><h3>Significance</h3><div>FCD IIIa and iHS exhibit several distinct electro-clinical features. The most important is a more impaired general cognitive profile associated with FCD IIIa, without differences in language or global memory.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111461"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG dynamics under anesthetics-induced loss and return of responsiveness with A constant rate infusion","authors":"Xiaoge Liu ,&nbsp;Yu Chang ,&nbsp;Xin Wang ,&nbsp;Shitong Li ,&nbsp;Zhenhu Liang ,&nbsp;Jun Zhang","doi":"10.1016/j.clinph.2025.2111411","DOIUrl":"10.1016/j.clinph.2025.2111411","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to characterize the electroencephalographic dynamics during the transition to and from loss of responsiveness (LOR) induced by three anesthetics.</div></div><div><h3>Methods</h3><div>High-density EEG was recorded in 60 patients randomly receiving propofol, dexmedetomidine, or ketamine with a constant rate infusion. Spectral power, phase-amplitude coupling (PAC), coherence and directed phase transfer entropy during awake, LOR and recovery (ROR) states were analyzed to evaluate neural dynamics associated with altered conscious states.</div></div><div><h3>Results</h3><div>Propofol increased global alpha power and low-frequency slow oscillations (SO) without “alpha anteriorization” during LOR. Dexmedetomidine increased SO but decreased alpha power. Ketamine reduced alpha power and increased occipital theta and gamma power. Further, three anesthetic displayed distinct PAC patterns and induced region-specific and frequency-specific long-range functional connectivity patterns. Directed connectivity analysis indicated propofol and ketamine rather than dexmedetomidine inhibited feedback connectivity during LOR.</div></div><div><h3>Conclusions</h3><div>Three anesthetics induced differential spectral power, PAC, and network connectivity during the transition to and from LOR when infused with a constant rate, suggesting that EEG dynamics vary not only among anesthetics, but also among regimens of their administration.</div></div><div><h3>Significance</h3><div>Anesthetic-specific neural signatures and administration-dependent EEG patterns, advance precision anesthesia monitoring and deepen understanding of conscious state transitions under distinct pharmacologic modulations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111411"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetoneurography as a novel functional imaging technique for cervical myelopathy","authors":"Shigenori Kawabata ,&nbsp;Yuko Hoshino ,&nbsp;Yoshiaki Adachi ,&nbsp;Taishi Watanabe ,&nbsp;Kensuke Sekihara ,&nbsp;Toru Sasaki ,&nbsp;Jun Hashimoto ,&nbsp;Satoshi Sumiya ,&nbsp;Atsushi Okawa ,&nbsp;Toshitaka Yoshii","doi":"10.1016/j.clinph.2025.2111409","DOIUrl":"10.1016/j.clinph.2025.2111409","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy of magnetoneurography (MNG) in examination of neurological conditions in degenerative cervical myelopathy.</div></div><div><h3>Methods</h3><div>The left median and ulnar nerves were electrically stimulated in 25 healthy participants and 21 patients. The evoked magnetic fields were recorded using a 132-channel superconducting quantum interference device biomagnetometer system and spatiotemporal changes in reconstructed action currents were evaluated. The correspondence of the MNG and MRI diagnoses with neurological findings was evaluated by two board-certified orthopaedists.</div></div><div><h3>Results</h3><div>Evoked magnetic fields were recorded in all participants. In 16 patients, there was no inconsistency between the MRI and MNG findings. In the remaining five cases, the lesions diagnosed by MNG were at a lower level than those diagnosed by MRI.</div></div><div><h3>Conclusions</h3><div>MNG was able to visualise the spatiotemporal course of neural currents, which is difficult to record in conventional electrophysiological examinations. Because the lesional level of the spinal cord in MRI is not always consistent with the neurological findings, MNG might be able to detect the electrophysiological change in the spinal cord at a level below the compression site.</div></div><div><h3>Significance</h3><div>MNG has the potential to be a comprehensible imaging technique and to provide novel neurological findings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111409"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145480543","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of electrode placement in subthalamic nucleus deep brain stimulation for improving gait in Parkinson’s Disease","authors":"Zhongke Mei ,&nbsp;Anna-Sophie Hofer ,&nbsp;Christian Baumann ,&nbsp;Mechtild Uhl ,&nbsp;Navrag Singh ,&nbsp;William R. Taylor ,&nbsp;Lennart Stieglitz ,&nbsp;Deepak K. Ravi","doi":"10.1016/j.clinph.2025.2111468","DOIUrl":"10.1016/j.clinph.2025.2111468","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between the spatial location of active electrode contacts in subthalamic nucleus deep brain stimulation (STN-DBS) and changes in gait performance in patients with Parkinson’s disease (PwPD).</div></div><div><h3>Methods</h3><div>This observational study included 49 PwPD who underwent bilateral STN-DBS. Spatiotemporal gait parameters were assessed before surgery and six months post-implantation using motion capture. Both mean values and variability of gait parameters were analyzed. Active contact locations were normalized using a voxel-based approach and statistically associated with gait outcomes.</div></div><div><h3>Results</h3><div>STN-DBS led to significant reductions in stride time, stance time, swing time, and step time, alongside increased step width and temporal gait variability. Gait improvements were associated with specific stimulation sites: the postero-superior STN region was most effective for enhancing mean spatial parameters (e.g., stride length, walking speed), while the antero-superior region was optimal for reducing temporal variability. Patients stimulated in these regions showed significantly better gait outcomes than those stimulated elsewhere.</div></div><div><h3>Conclusions</h3><div>Gait improvements were differentially associated with the spatial location of stimulation electrode within the STN, suggesting region-specific modulation of mean spatial and temporal variability gait parameters.</div></div><div><h3>Significance</h3><div>These findings support precision targeting of stimulation sites to optimize patient-specific gait outcomes, advancing personalized DBS therapy in Parkinson’s disease.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111468"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145713210","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimal parameters for reliable PMv–M1 facilitation identified with dual coil TMS","authors":"N. Bevacqua ,&nbsp;S. Turrini ,&nbsp;A. Avenanti","doi":"10.1016/j.clinph.2025.2111434","DOIUrl":"10.1016/j.clinph.2025.2111434","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111434"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145518421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Decoding alzheimer’s: The role of EEG rhythms and aperiodic components in cognitive decline","authors":"Mingyang Zhang ,&nbsp;Xia Liu ,&nbsp;Yanan Ren ,&nbsp;Lixuan Li ,&nbsp;Ruoyu Wang ,&nbsp;Lihui Sun ,&nbsp;Qinying Ma","doi":"10.1016/j.clinph.2025.2111437","DOIUrl":"10.1016/j.clinph.2025.2111437","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate detailed alterations in brain electrical activity and their relationship with cognitive decline in Alzheimer’s disease (AD) using electroencephalogram (EEG) power spectrum analysis.</div></div><div><h3>Methods</h3><div>EEG data from 80 AD patients and 80 healthy control (HC) were analyzed, focusing on theta and alpha band powers, aperiodic offset, and exponent. Topographic and gender-specific analyses were conducted to explore associations with disease progression and cognitive impairment.</div></div><div><h3>Results</h3><div>AD patients showed increased theta and alpha band powers, with theta band power exhibiting statistically significant differences. Globally elevated theta band power correlated with cognitive impairment severity. Higher aperiodic offsets and exponents were observed in AD patients, exhibiting upward trends with disease progression. Male AD patients displayed more pronounced EEG abnormalities and unique Montreal Cognitive Assessment (MOCA) score patterns.</div></div><div><h3>Conclusions</h3><div>Our findings highlight the critical role of theta band power in AD pathology and suggest potential EEG biomarkers for neurodegenerative changes. Gender-specific differences emphasize the importance of personalized approaches in AD diagnosis and treatment.</div></div><div><h3>Significance</h3><div>This study provides novel neurophysiological insights into AD, underscoring the clinical utility of EEG markers and the necessity for gender-specific considerations in precision medicine for AD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111437"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145569535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Between Mind and Movement: Electrophysiological insights into functional dystonia","authors":"Alexey Sedov ,&nbsp;Ulia Semenova ,&nbsp;Anna Gamaleya ,&nbsp;Alexey Tomskiy ,&nbsp;Aasef G. Shaikh","doi":"10.1016/j.clinph.2025.2111442","DOIUrl":"10.1016/j.clinph.2025.2111442","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111442"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145569626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EEG-based stratification in Alzheimer’s disease: Cognitive progression, pathological marker associations, and therapeutic interventions","authors":"Zian Pei ,&nbsp;Lin Zhu ,&nbsp;Huixia Ren ,&nbsp;Yumei Liu ,&nbsp;Xue Shi ,&nbsp;Yun Lin ,&nbsp;Jing Wang ,&nbsp;Pan Li ,&nbsp;Pan Wang ,&nbsp;Yong Ji ,&nbsp;Yuying Zhou ,&nbsp;Xiaoying Tang ,&nbsp;Xin Jiang ,&nbsp;Xiaoguang Tong ,&nbsp;Yi Guo","doi":"10.1016/j.clinph.2025.2111440","DOIUrl":"10.1016/j.clinph.2025.2111440","url":null,"abstract":"<div><h3>Objective</h3><div>Clinical cognitive and pathological marker stratification systems have evolved separately, causing mismatches that limit their clinical use. This study retrospectively validated the link between EEG and clinical symptoms, pathological markers, and the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS).</div></div><div><h3>Methods</h3><div>This multicenter study involved 308 Alzheimer’s patients (AD), 176 with Parkinson’s (PD), and 181 normal controls. Resting-state EEG were analyzed to identify four oscillation modes. An EEG-based cognitive risk system was created and validated, also evaluating its effect on rTMS therapy effectiveness.</div></div><div><h3>Results</h3><div>EEG oscillation changes correlated with cognitive decline, revealing distinct brain network disruptions in AD and PD. These oscillation changes were associated with AD biomarkers, particularly tau hyperphosphorylation. Multicenter validation showed an 83% concordance with the Clinical Dementia Rating Scale, and EEG stratification enhanced rTMS therapeutic efficacy.</div></div><div><h3>Conclusions</h3><div>This study showed that EEG-based stratification can assess cognitive function, track disease progression, identify key intervention periods, and improve patient selection for better treatment outcomes in clinical settings.</div></div><div><h3>Significance</h3><div>This study demonstrates that EEG can connect disease processes to clinical symptoms at a molecular level, offering a unified framework for improved dementia management. This method allows for dynamic monitoring and precise neuromodulation, enhancing personalized care for neurodegenerative diseases.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111440"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identifying the epileptogenic zone by 18F-FDG PET/MRI in drug-resistant epilepsy with focal cortical dysplasia type IIIa","authors":"Lingling Zhang ,&nbsp;Hailing Zhou ,&nbsp;Yongjin Tang ,&nbsp;Jiefeng Gan ,&nbsp;Xiangshu Hu ,&nbsp;Hainan Li ,&nbsp;Xueying Ling ,&nbsp;Qiang Guo ,&nbsp;Hao Xu","doi":"10.1016/j.clinph.2025.2111412","DOIUrl":"10.1016/j.clinph.2025.2111412","url":null,"abstract":"<div><h3>Objective</h3><div>Focal cortical dysplasia (FCD) type IIIa, distinct from isolated FCD in drug-resistant epilepsy, is typically confirmed via postoperative histopathology. This study aimed to evaluate the diagnostic utility of preoperative noninvasive ¹⁸F-fludeoxyglucose (FDG) PET/MRI co-registration in localizing the epileptogenic zone (EZ) in FCD type IIIa.</div></div><div><h3>Methods</h3><div>We performed a retrospective study that included 60 patients with FCD type IIIa who underwent resection for drug-resistant epilepsy. The sensitivity of each modality for localizing the EZ was calculated, with invasive stereoelectroencephalography (SEEG) as a reference. Diagnostic accuracy and value of each modality were further assessed with respect to SEEG and postoperative outcomes for all patients and MRI negative/doubtful patients.</div></div><div><h3>Results</h3><div>We analyzed the diagnostic value of the different non-invasive diagnostic techniques with respect to concordance with SEEG findings and postsurgical seizure outcomes. For all included patients, ¹⁸F-FDG PET/MRI showed the highest sensitivity (75.7 %) for localizing the EZ across all modalities. We also found that ¹⁸F-FDG PET/MRI demonstrated the best accuracy and diagnostic value for localizing the EZ (60.0 %). Among MRI-doubtful/negative patients, ¹⁸F-FDG PET/MRI not only showed the highest sensitivity (79.3 %) but also achieved most promising accuracy and diagnostic value for identifying the EZ (61.7 % accuracy) across all modalities.</div></div><div><h3>Significance</h3><div>¹⁸F-FDG PET/MRI coregistration appears to be overwhelmingly rewarding in affording localization of EZ for patients with FCD type IIIa. This technique is potentially valuable as a noninvasive method to identify the EZ in patients with drug-resistant epilepsy due to FCD type IIIa, especially for MRI-negative/doubtful patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111412"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145511930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deriving reference limits from historical data – A comparison of four novel methods","authors":"Tomasz Szymon Szczepanski ,&nbsp;Petter Moe Omland ,&nbsp;Øystein Dunker ,&nbsp;Trond Sand ,&nbsp;Martijn Tannemaat ,&nbsp;Robert Reijntjes ,&nbsp;Anis Yazidi ,&nbsp;Kerstin Bach ,&nbsp;John Anker Zwart ,&nbsp;Joe Jabre ,&nbsp;Kristian Bernhard Nilsen","doi":"10.1016/j.clinph.2025.2111451","DOIUrl":"10.1016/j.clinph.2025.2111451","url":null,"abstract":"<div><h3>Objective</h3><div>To compare four novel methods – extrapolated norms (E-norms), extrapolated reference values (E-Ref), multivariable extrapolated reference values (MeRef) and mixture model clustering (MMC) – for obtaining reference limits for nerve conduction studies (NCS) from historical data containing both normal and abnormal studies.</div></div><div><h3>Methods</h3><div>Reference limits for 29 commonly clinically used NCS measurements were calculated from a historical database containing measurements from 24<!--> <!-->618 patients using E-norms, E-ref, MeRef and MMC. The resulting reference limits were compared to reference limits for NCS calculated from 680 healthy subjects using Youden’s J statistics.</div></div><div><h3>Results</h3><div>Except for distal latencies, E-norms produced reference limits with the highest Youden’s J statistics with higher sensitivity, but lower specificity. E-Ref, MeRef and MMC produced reference limits with high specificity, but lower sensitivity than E-norms.</div></div><div><h3>Conclusions</h3><div>There are substantial differences in the performance of E-norms, E-Ref, MeRef and MMC. A dynamic approach, where the methods used are changed based on the type of NCS measurement and the amount of historical data available, may yield the highest accuracy.</div></div><div><h3>Significance</h3><div>When combining the different novel methods, it is possible to create clinically useful reference limits using historical data.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111451"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145616692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}