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Accelerated intermittent theta burst transcranial magnetic stimulation of the dorsolateral prefrontal cortex for chronic knee osteoarthritis pain 加速间歇性θ波爆发经颅磁刺激背外侧前额皮质治疗慢性膝骨关节炎疼痛。
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.02.267
Duncan J. Hodkinson , Marianne M. Drabek , Suzanne Horvath , Stefan Pszczolkowski , Christopher Tench , Radu Tanasescu , Sudheer T. Lankappa , David A. Walsh , Richard Morriss , Dorothee P. Auer
{"title":"Accelerated intermittent theta burst transcranial magnetic stimulation of the dorsolateral prefrontal cortex for chronic knee osteoarthritis pain","authors":"Duncan J. Hodkinson ,&nbsp;Marianne M. Drabek ,&nbsp;Suzanne Horvath ,&nbsp;Stefan Pszczolkowski ,&nbsp;Christopher Tench ,&nbsp;Radu Tanasescu ,&nbsp;Sudheer T. Lankappa ,&nbsp;David A. Walsh ,&nbsp;Richard Morriss ,&nbsp;Dorothee P. Auer","doi":"10.1016/j.clinph.2025.02.267","DOIUrl":"10.1016/j.clinph.2025.02.267","url":null,"abstract":"<div><h3>Objective</h3><div>This study assessed feasibility, safety, and tolerability of accelerated intermittent theta burst stimulation (aiTBS) with effective connectivity-guidance targeting the left dorsolateral prefrontal cortex (lDLPFC) from the right anterior insular (rAI) in chronic knee osteoarthritis pain.</div></div><div><h3>Methods</h3><div>The BoostCPM clinical trial (ISRCTN15404076) was a randomized, sham-controlled, single-blind, parallel-group pilot study in patients with mild-moderate chronic pain. Participants were assigned 2:1 (active: sham) aiTBS for 4 consecutive days (totaling 36,000 pulses) at a daily dose of 9000 pulses (5 sessions of 1800 pulses). Primary outcomes included safety, tolerability, pain-related and affective outcomes, and quantitative sensory testing.</div></div><div><h3>Results</h3><div>45 participants received active (n = 33) or sham (n = 12) aiTBS. No serious adverse events were recorded, and protocol adherence (tolerability) was 80.6 % and 100 % for active and sham. Follow-up response rate was 78.1 % and overall acceptance/satisfaction was 89 %. Pain relief was observed immediately after treatment and lasted 16 weeks with clinically meaningful reduction of pain burden, but no differences between groups.</div></div><div><h3>Conclusions</h3><div>aiTBS with rAI-connected lDLPFC targeting is a safe, well tolerated, feasible, and acceptable intervention in chronic pain patients. However, we found no additional improvements compared to sham. <em><u>Significance:</u></em> <u>F</u>urther studies of aiTBS and lDLPFC targeting for pain relief are warranted.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2010680"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cerebral flow dynamics in electroconvulsive therapy – A pilot study for implementation of color-coded duplex sonography 电休克治疗中的脑血流动力学——彩色编码双超音波实现的初步研究
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110832
Rebecca Paetow , Jan Heckelmann , Maike Dohrn , Aileen Hill , Manuel Dafotakis , Jörg B. Schulz , Jan Larmann , Thomas Frodl
{"title":"Cerebral flow dynamics in electroconvulsive therapy – A pilot study for implementation of color-coded duplex sonography","authors":"Rebecca Paetow ,&nbsp;Jan Heckelmann ,&nbsp;Maike Dohrn ,&nbsp;Aileen Hill ,&nbsp;Manuel Dafotakis ,&nbsp;Jörg B. Schulz ,&nbsp;Jan Larmann ,&nbsp;Thomas Frodl","doi":"10.1016/j.clinph.2025.2110832","DOIUrl":"10.1016/j.clinph.2025.2110832","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110832"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
It’s an illusion – or how our brain makes us belief in seeing things that are not there 这是一种错觉，或者说我们的大脑让我们相信看到了不存在的东西
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110882
Ina Thome , Kristin Rusch , Aicha Bouzouina , Andreas Jansen
{"title":"It’s an illusion – or how our brain makes us belief in seeing things that are not there","authors":"Ina Thome ,&nbsp;Kristin Rusch ,&nbsp;Aicha Bouzouina ,&nbsp;Andreas Jansen","doi":"10.1016/j.clinph.2025.2110882","DOIUrl":"10.1016/j.clinph.2025.2110882","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110882"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043879","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Muscle sonography in myositis antibodies: no additional benefit? 肌炎抗体的肌肉超声检查：没有额外的益处？
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110888
Benedict Kleiser , David Hoffmann , Hanna Seifermann , Markus C. Kowarik , Evelyn Dubois , Marcel Armbruster , Alexander M. Grimm , Justus Marquetand
{"title":"Muscle sonography in myositis antibodies: no additional benefit?","authors":"Benedict Kleiser ,&nbsp;David Hoffmann ,&nbsp;Hanna Seifermann ,&nbsp;Markus C. Kowarik ,&nbsp;Evelyn Dubois ,&nbsp;Marcel Armbruster ,&nbsp;Alexander M. Grimm ,&nbsp;Justus Marquetand","doi":"10.1016/j.clinph.2025.2110888","DOIUrl":"10.1016/j.clinph.2025.2110888","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110888"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Functional connectivity correlates of temporal order memory in healthy older adults 功能连接与健康老年人时间顺序记忆的关系
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110845
Catalina Trujillo-Llano , Nina Ehrhardt , Anna Fromm , Friederike Thams , Shu-Chen Li , Agnes Flöel , Daria Antonenko
{"title":"Functional connectivity correlates of temporal order memory in healthy older adults","authors":"Catalina Trujillo-Llano ,&nbsp;Nina Ehrhardt ,&nbsp;Anna Fromm ,&nbsp;Friederike Thams ,&nbsp;Shu-Chen Li ,&nbsp;Agnes Flöel ,&nbsp;Daria Antonenko","doi":"10.1016/j.clinph.2025.2110845","DOIUrl":"10.1016/j.clinph.2025.2110845","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110845"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Semi-automated MRI muscle volumetry and systematic muscle and nerve ultrasound in the diagnostic field of hereditary polyneuropathies: a longitudinal study 半自动化MRI肌肉体积测量和系统肌肉和神经超声在遗传性多神经病变诊断领域：一项纵向研究
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110865
Kim L. Vockert , Teresa Lemainque , Friederike Kirschmann , Jörg B. Schulz , Natalie Winter , Maike Dohrn
{"title":"Semi-automated MRI muscle volumetry and systematic muscle and nerve ultrasound in the diagnostic field of hereditary polyneuropathies: a longitudinal study","authors":"Kim L. Vockert ,&nbsp;Teresa Lemainque ,&nbsp;Friederike Kirschmann ,&nbsp;Jörg B. Schulz ,&nbsp;Natalie Winter ,&nbsp;Maike Dohrn","doi":"10.1016/j.clinph.2025.2110865","DOIUrl":"10.1016/j.clinph.2025.2110865","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110865"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroanatomical correlates of multi-step actions: Analysis of structural white matter connectivity 多步骤动作的神经解剖学相关性：结构白质连通性分析
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110839
Ema Birute Vaidelyte, Cornelius Weiller, Michel Rijntjes, Marco Reisert, Markus Martin, Andrea Dreßing
{"title":"Neuroanatomical correlates of multi-step actions: Analysis of structural white matter connectivity","authors":"Ema Birute Vaidelyte,&nbsp;Cornelius Weiller,&nbsp;Michel Rijntjes,&nbsp;Marco Reisert,&nbsp;Markus Martin,&nbsp;Andrea Dreßing","doi":"10.1016/j.clinph.2025.2110839","DOIUrl":"10.1016/j.clinph.2025.2110839","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110839"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044337","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effect of stroke lesion size and white matter tract lesion probability on dynamic graph measures 脑卒中损伤大小和白质束损伤概率对动态图测量的影响
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110854
Ji-Won Kim , Azamat Yeldesbay , Nils Rosjat , Marina Sazhumyan , Eva Nießen , Peter H. Weiß-Blankenhorn , Gereon R. Fink , Silvia Daun
{"title":"The effect of stroke lesion size and white matter tract lesion probability on dynamic graph measures","authors":"Ji-Won Kim ,&nbsp;Azamat Yeldesbay ,&nbsp;Nils Rosjat ,&nbsp;Marina Sazhumyan ,&nbsp;Eva Nießen ,&nbsp;Peter H. Weiß-Blankenhorn ,&nbsp;Gereon R. Fink ,&nbsp;Silvia Daun","doi":"10.1016/j.clinph.2025.2110854","DOIUrl":"10.1016/j.clinph.2025.2110854","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110854"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Kinesthetic and tactile perception thresholds of somatosensory stimuli and proprioception in movement disorders 运动障碍中体感刺激和本体感觉的动觉和触觉知觉阈值
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110855
Annika Junge, Thorsten Odorfer, Daniel Zeller
{"title":"Kinesthetic and tactile perception thresholds of somatosensory stimuli and proprioception in movement disorders","authors":"Annika Junge,&nbsp;Thorsten Odorfer,&nbsp;Daniel Zeller","doi":"10.1016/j.clinph.2025.2110855","DOIUrl":"10.1016/j.clinph.2025.2110855","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110855"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145044354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Beyond beta: subthalamic gamma and broadband power reflect Parkinson’s disease severity – A multi-center study 一项多中心研究：下丘脑伽马和宽带功率反映帕金森病的严重程度
IF 3.6 3区 医学
Clinical Neurophysiology Pub Date : 2025-08-01 DOI: 10.1016/j.clinph.2025.2110896
Moritz Gerster , Gunnar Waterstraat , Thomas Binns , Natasha Darcy , Christoph Wiest , Richard Koehler , Jojo Vanhoecke , Lukasz Radzinski , Patricia Krause , Katharina Faust , Gerd-Helge Schneider , Matthias Sure , Dmitrii Todorov , Keyoumars Ashkan , Erlick Pereira , Arno Villringer , Jan Hirschmann , Andrea Kühn , Esther Florin , Alfons Schnitzler , Vadim Nikulin
{"title":"Beyond beta: subthalamic gamma and broadband power reflect Parkinson’s disease severity – A multi-center study","authors":"Moritz Gerster ,&nbsp;Gunnar Waterstraat ,&nbsp;Thomas Binns ,&nbsp;Natasha Darcy ,&nbsp;Christoph Wiest ,&nbsp;Richard Koehler ,&nbsp;Jojo Vanhoecke ,&nbsp;Lukasz Radzinski ,&nbsp;Patricia Krause ,&nbsp;Katharina Faust ,&nbsp;Gerd-Helge Schneider ,&nbsp;Matthias Sure ,&nbsp;Dmitrii Todorov ,&nbsp;Keyoumars Ashkan ,&nbsp;Erlick Pereira ,&nbsp;Arno Villringer ,&nbsp;Jan Hirschmann ,&nbsp;Andrea Kühn ,&nbsp;Esther Florin ,&nbsp;Alfons Schnitzler ,&nbsp;Vadim Nikulin","doi":"10.1016/j.clinph.2025.2110896","DOIUrl":"10.1016/j.clinph.2025.2110896","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110896"},"PeriodicalIF":3.6,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145043893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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