Clinical Neurophysiology最新文献

{"title":"Stimulate to probe, stimulate to modulate: Single-pulse brain stimulation to titrate neuromodulation.","authors":"Simone Russo, Mario Rosanova","doi":"10.1016/j.clinph.2025.2110737","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2110737","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110737"},"PeriodicalIF":3.7,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Introducing the Trigemino-Vocal Reflex: New insights to assess brainstem connectivity under general anesthesia","authors":"Javier Urriza ,&nbsp;Isabel Fernandez-Conejero ,&nbsp;Kathleen Seidel ,&nbsp;Sedat Ulkatan","doi":"10.1016/j.clinph.2025.2110739","DOIUrl":"10.1016/j.clinph.2025.2110739","url":null,"abstract":"<div><h3>Objective</h3><div>This descriptive study aims to provide evidence of a newly described reflex, the Trigemino-Vocal Reflex (TVcR). It confirms the functional connectivity between trigeminal and vagal systems in humans under anesthesia.</div></div><div><h3>Methods</h3><div>We stimulated the mental branch of the trigeminal nerve at the mandibular foramen in 47 patients undergoing different surgeries and recorded vocal cord muscle responses. Stimulation consisted of either a single electrical pulse or a train of 2–4 pulses, based on anesthesia depth. The recording was made by using an adhesive tube electrode.</div></div><div><h3>Results</h3><div>A bilateral response was observed in 41 patients, while 2 showed only a unilateral response. All 43 exhibited an early potential (R1) with a latency of about 30 ms, and 24 also displayed a late potential (R2) with a latency of<!--> <!-->around 65 ms.</div></div><div><h3>Conclusions</h3><div>We demonstrate the potential to record the newly described TVcR, recording vagal motor responses in the vocal cords following stimulation of the trigeminal nerve at the mandibular foramen in anesthetized patients.</div></div><div><h3>Significance</h3><div>We introduce a newly described reflex that may be valuable in intraoperative neurophysiological monitoring and could enhance our understanding of brainstem physiology.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110739"},"PeriodicalIF":3.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ankle proprioception and the relationship to rigidity in Parkinson’s disease","authors":"Jacquelyn V.L. Sertic ,&nbsp;Jason Kang ,&nbsp;Colum D. MacKinnon ,&nbsp;Jürgen Konczak","doi":"10.1016/j.clinph.2025.2110740","DOIUrl":"10.1016/j.clinph.2025.2110740","url":null,"abstract":"<div><h3>Objective</h3><div>Proprioceptive mechanoreceptor afferents form the basis for the perception of body position and muscle tone regulation. Parkinson’s disease (PD) is associated with proprioceptive dysfunction. This study aimed to characterize the extent of ankle position sense dysfunction in PD and its relationship with abnormal muscle tone.</div></div><div><h3>Methods</h3><div>Sixteen people with PD and 16 controls participated. Using a 2-forced-choice psychophysical paradigm, a participant’s ankle was passively rotated to two positions – a reference of 15° plantarflexion and a smaller amplitude comparison position. Subsequently, the user verbally indicated which position was perceived as more plantarflexed. From the stimulus–response data a just-noticeable-difference (JND) threshold and uncertainty area (UA) were derived as measures of ankle position sense acuity. Muscle rigidity was assessed using the MDS-UPDRS III scale.</div></div><div><h3>Results</h3><div>Both median JND threshold and UA were significantly elevated in the group with PD compared to controls (<em>p</em> &lt; 0.05). JND threshold correlated positively with lower extremity rigidity (<em>p =</em> 0.047).</div></div><div><h3>Conclusion</h3><div>PD can lead to reduced ankle position sense acuity. Lower proprioceptive acuity tended to be associated with higher rigidity, suggesting that PD broadly alters proprioceptive signal processing affecting both perception and regulation of muscle tone.</div></div><div><h3>Significance</h3><div>Impairments in proprioceptive processing contribute to both proprioceptive dysfunction and rigidity in PD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110740"},"PeriodicalIF":3.7,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072634","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fast ripple band high-frequency activity associated with thalamic sleep spindles in pediatric epilepsy","authors":"Atsuro Daida ,&nbsp;Yuanyi Ding ,&nbsp;Yipeng Zhang ,&nbsp;Shingo Oana ,&nbsp;Saarang Panchavati ,&nbsp;Benjamin D. Edmonds ,&nbsp;Samuel S. Ahn ,&nbsp;Noriko Salamon ,&nbsp;Raman Sankar ,&nbsp;Aria Fallah ,&nbsp;Richard J. Staba ,&nbsp;Jerome Engel Jr. ,&nbsp;William Speier ,&nbsp;Vwani Roychowdhury ,&nbsp;Hiroki Nariai","doi":"10.1016/j.clinph.2025.01.011","DOIUrl":"10.1016/j.clinph.2025.01.011","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate high-frequency activities (HFA) associated with thalamic sleep spindles.</div></div><div><h3>Methods</h3><div>We studied a cohort of ten pediatric patients with medication resistant epilepsy who were identified as potential candidates for thalamic neuromodulation. These patients had thalamic sampling as well as presumed epileptogenic zones, using stereotactic EEG (SEEG) with a sampling frequency of 2,000 Hz. We quantified the summated high-frequency activity (HFA) in the fast ripple band associated with sleep spindles using 20-minute scalp EEG and SEEG recordings during non-REM sleep and analyzed its correlation with spindle characteristics.</div></div><div><h3>Results</h3><div>HFA, with a median peak frequency of 330 Hz, was distinctively observed in the thalamus and temporally correlated with thalamic sleep spindles. Such HFA demonstrated significant coupling with the sleep spindle range of 11–16 Hz. The duration of HFA positively correlated with higher density and longer duration of accompanying thalamic spindles. Thalamic HFA’s duration negatively correlated with the presence of cortical interictal epileptiform discharges. Thalamic spindles generated in channels with HFA often coincided with sleep spindles in various brain regions.</div></div><div><h3>Conclusion</h3><div>Fast ripple band HFA associated with sleep spindles was observed exclusively in the thalamus.</div></div><div><h3>Significance</h3><div>Thalamic HFA associated with thalamic spindles may represent a thalamus-specific physiological phenomenon.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 241-251"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143364119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural correlates of semantic and phonemic variants of verbal fluency tasks: A combined MEG and fMRI study","authors":"Alexandru Mihai Dumitrescu ,&nbsp;Tim Coolen ,&nbsp;Vincent Wens ,&nbsp;Antonin Rovai ,&nbsp;Nicola Trotta ,&nbsp;Charline Urbain ,&nbsp;Xavier De Tiège","doi":"10.1016/j.clinph.2025.01.015","DOIUrl":"10.1016/j.clinph.2025.01.015","url":null,"abstract":"<div><h3>Objective</h3><div>The neural correlates of verbal fluency tasks (VFT) have been characterized by functional magnetic resonance imaging (fMRI). Still, the spatio-spectral neural oscillatory dynamics elicited by VFT and the differences between their semantic and phonologic variants are unsettled. We investigate, using fMRI and magnetoencephalography (MEG), the neural correlates of VFT and the differences in neural oscillatory dynamics between phonological (PFT) and semantic (SFT) fluency tasks.</div></div><div><h3>Methods</h3><div>Thirty right-handed healthy adults underwent MEG and fMRI recordings while performing covert PFT and SFT.</div></div><div><h3>Results</h3><div>fMRI showed different neural networks for PFT (left-dominant lexical-semantic control network) and SFT (nodes of the left-dominant semantic network). MEG showed beta-band power suppression in the left operculum in both VFT, with no difference between PFT and SFT.</div></div><div><h3>Conclusions</h3><div>MEG and fMRI detect distinct task-induced neural activity changes during VFT. MEG findings likely reflect the neural consequences of covert word production initiated at the inferior/middle frontal gyri, as identified by fMRI.</div></div><div><h3>Significance</h3><div>This study demonstrates the added value of combining MEG and fMRI to fully characterize VFT network dynamics. It paves the way for the use of VFT for non-invasive presurgical language mapping using a method free of neurovascular uncoupling.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 256-267"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143413696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous muscle activity in multifocal motor neuropathy – Insights from axonal excitability testing","authors":"Christian Krarup ,&nbsp;Nils Wolfram ,&nbsp;Siska Frahm-Falkenberg ,&nbsp;Carolina C. Graffe ,&nbsp;Tina Dysgaard ,&nbsp;Ali Al-Zuhairy ,&nbsp;Johannes K. Jakobsen ,&nbsp;Mihai Moldovan","doi":"10.1016/j.clinph.2024.12.019","DOIUrl":"10.1016/j.clinph.2024.12.019","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate motor axonal excitability in multifocal motor neuropathy (MMN) associated with involuntary muscle activity.</div></div><div><h3>Methods</h3><div>Two MMN patients with continuous involuntary finger movements (MMNifm) were compared to 11 patients without movements (MMNnfm). Clinical examination, EMG of the abductor pollicis brevis muscle, nerve conduction studies, motor unit number estimation, excitability studies, and mathematical modeling were conducted in the patients with MMN and compared to controls.</div></div><div><h3>Results</h3><div>Weakness, axonal loss, conduction block, or both occurred in the median nerve in the MMNifm and the MMNnfm patients. Ultrasound studies (US) in MMNifm showed enlargement of the nerves at the axilla/brachial plexus at the site of the conduction block. In MMNifm, EMG and the US showed continuous involuntary contractions, and excitability studies of the median nerve at the wrist showed increased threshold reduction during early depolarizing electrotonus and at early recovery cycle (superexcitability). Mathematical modeling was consistent with reduced fast K⁺ current more pronounced in MMNifm than in MMNnfm.</div></div><div><h3>Conclusions</h3><div>MMN may have a spectrum of changes associated with instability of the axonal membrane which may be due to paranodal myelin loosening.</div></div><div><h3>Significance</h3><div>In addition to motor conduction block and axonal loss, MMN has pathophysiological changes that suggest more widespread involvement of motor myelinated fibers.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 229-238"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143036878","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combining MEG with fMRI reveal complementary brain activity elicited by verbal fluency tasks performed by neurotypical adults","authors":"Stavros I Dimitriadis","doi":"10.1016/j.clinph.2025.03.005","DOIUrl":"10.1016/j.clinph.2025.03.005","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 252-255"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143639483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Finding a new normal: Thalamic stereo EEG reveals physiological fast ripples","authors":"William C. Stacey","doi":"10.1016/j.clinph.2025.03.004","DOIUrl":"10.1016/j.clinph.2025.03.004","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 239-240"},"PeriodicalIF":3.7,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnosis of carpal tunnel syndrome using deep learning with comparative guidance","authors":"Jungsub Sim ,&nbsp;Sungche Lee ,&nbsp;Seunghyun Kim ,&nbsp;Seong-ho Jeong ,&nbsp;Joonshik Yoon ,&nbsp;Seungjun Baek","doi":"10.1016/j.clinph.2025.03.038","DOIUrl":"10.1016/j.clinph.2025.03.038","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to develop a deep learning model for a robust diagnosis of Carpal Tunnel Syndrome (CTS) based on comparative classification leveraging the ultrasound images of the thenar and hypothenar muscles.</div></div><div><h3>Methods</h3><div>We recruited 152 participants, both patients with varying severities of CTS and healthy individuals. The enrolled patients underwent ultrasonography, which provided ultrasound image data of the thenar and hypothenar muscles from the median and ulnar nerves. These images were used to train a deep learning model. We compared the performance of our model with previous comparative methods using echo intensity ratio or machine learning, and non-comparative methods based on deep learning. During the training process, comparative guidance based on cosine similarity was used so that the model learns to automatically identify the abnormal differences in echotexture between the ultrasound images of the thenar and hypothenar muscles.</div></div><div><h3>Results</h3><div>The proposed deep learning model with comparative guidance showed the highest performance. The comparison of Receiver operating characteristic (ROC) curves between models demonstrated that the Comparative guidance was effective in autonomously identifying complex features within the CTS dataset.</div></div><div><h3>Conclusions</h3><div>The proposed deep learning model with comparative guidance was shown to be effective in automatically identifying important features for CTS diagnosis from the ultrasound images. The proposed comparative approach was found to be robust to the traditional problems in ultrasound image analysis such as different cut-off values and anatomical variation of patients.</div></div><div><h3>Significance</h3><div>Proposed deep learning methodology facilitates accurate and efficient diagnosis of CTS from ultrasound images.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"174 ","pages":"Pages 191-197"},"PeriodicalIF":3.7,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143882028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visualization of functional and effective connectivity underlying auditory descriptive naming","authors":"Yu Kitazawa ,&nbsp;Kazuki Sakakura ,&nbsp;Hiroshi Uda ,&nbsp;Naoto Kuroda ,&nbsp;Riyo Ueda ,&nbsp;Ethan Firestone ,&nbsp;Min-Hee Lee ,&nbsp;Jeong-Won Jeong ,&nbsp;Masaki Sonoda ,&nbsp;Shin-ichiro Osawa ,&nbsp;Kazushi Ukishiro ,&nbsp;Makoto Ishida ,&nbsp;Kazuo Kakinuma ,&nbsp;Shoko Ota ,&nbsp;Yutaro Takayama ,&nbsp;Keiya Iijima ,&nbsp;Toshimune Kambara ,&nbsp;Hidenori Endo ,&nbsp;Kyoko Suzuki ,&nbsp;Nobukazu Nakasato ,&nbsp;Eishi Asano","doi":"10.1016/j.clinph.2025.04.008","DOIUrl":"10.1016/j.clinph.2025.04.008","url":null,"abstract":"<div><h3>Objective</h3><div>We visualized functional and effective connectivity within specific white matter networks in response to auditory descriptive questions.</div></div><div><h3>Methods</h3><div>We investigated 40 Japanese-speaking patients with focal epilepsy and estimated connectivity measures using cortical high-gamma dynamics and MRI tractography.</div></div><div><h3>Results</h3><div>Hearing a <em>wh</em>-interrogative at question onset enhanced inter-hemispheric functional connectivity, with left-to-right callosal facilitatory flows between the superior-temporal gyri, contrasted by functional connectivity diminution with right-to-left callosal suppressive flows between dorsolateral prefrontal regions. Processing verbs associated with concrete objects or adverbs increased left intra-hemispheric connectivity, with bidirectional facilitatory flows through extensive white matter pathways. Questions beginning with <em>what</em>, compared to <em>where</em>, induced greater neural engagement in the left posterior inferior-frontal gyrus at question offset, linked to enhanced functional connectivity and bidirectional facilitatory flows to the temporal lobe neocortex via the arcuate fasciculus. During overt responses, inter-hemispheric functional connectivity was enhanced, with bidirectional callosal flows between Rolandic areas, and individuals with higher IQ scores exhibited less prolonged neural engagement in the left posterior middle frontal gyrus.</div></div><div><h3>Conclusions</h3><div>Visualization of directional neural interactions within white matter networks during overt naming is feasible.</div></div><div><h3>Significance</h3><div>Phrase order may influence network dynamics in listeners, even when presented with auditory descriptive questions conveying similar meanings.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2010729"},"PeriodicalIF":3.7,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}