Clinical Neurophysiology最新文献_第6页

A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-28 DOI: 10.1016/j.clinph.2025.01.004

Keith R. Murphy , Tulika Nandi , Benjamin Kop , Takahiro Osada , Maximilian Lueckel , W. Apoutou N’Djin , Kevin A. Caulfield , Anton Fomenko , Hartwig R. Siebner , Yoshikazu Ugawa , Lennart Verhagen , Sven Bestmann , Eleanor Martin , Kim Butts Pauly , Elsa Fouragnan , Til Ole Bergmann

{"title":"A practical guide to transcranial ultrasonic stimulation from the IFCN-endorsed ITRUSST consortium","authors":"Keith R. Murphy , Tulika Nandi , Benjamin Kop , Takahiro Osada , Maximilian Lueckel , W. Apoutou N’Djin , Kevin A. Caulfield , Anton Fomenko , Hartwig R. Siebner , Yoshikazu Ugawa , Lennart Verhagen , Sven Bestmann , Eleanor Martin , Kim Butts Pauly , Elsa Fouragnan , Til Ole Bergmann","doi":"10.1016/j.clinph.2025.01.004","DOIUrl":"10.1016/j.clinph.2025.01.004","url":null,"abstract":"<div><div>Low-intensity Transcranial Ultrasonic Stimulation (TUS) is a non-invasive brain stimulation technique enabling cortical and deep brain targeting with unprecedented spatial accuracy. Given the high rate of adoption by new users with varying levels of expertise and interdisciplinary backgrounds, practical guidelines are needed to ensure state-of-the-art TUS application and reproducible outcomes. Therefore, the International Transcranial Ultrasonic Stimulation Safety and Standards (ITRUSST) consortium has formed a subcommittee, endorsed by the International Federation of Clinical Neurophysiology (IFCN), to develop recommendations for best practices in human TUS applications. The practical guide presented here provides a brief introduction into ultrasound physics and sonication parameters. It explains the requirements of TUS lab equipment and transducer selection and discusses experimental design and procedures alongside potential confounds and control conditions. Finally, the guide elaborates on essential steps of application planning for stimulation safety and efficacy, as well as considerations when combining TUS with neuroimaging, electrophysiology, or other brain stimulation techniques. We hope that this practical guide to TUS will assist both novice and experienced users in planning and conducting high-quality studies and provide a solid foundation for further advancements in this promising field.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 192-226"},"PeriodicalIF":3.7,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143376825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VNS-induced dose-dependent pupillary response in refractory epilepsy

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-27 DOI: 10.1016/j.clinph.2025.01.006

Andrés Torres Sánchez , Marie Dawant , Venethia Danthine , Inci Cakiroglu , Roberto Santalucia , Enrique Ignacio Germany Morrison , Antoine Nonclercq , Riëm El Tahry

{"title":"VNS-induced dose-dependent pupillary response in refractory epilepsy","authors":"Andrés Torres Sánchez , Marie Dawant , Venethia Danthine , Inci Cakiroglu , Roberto Santalucia , Enrique Ignacio Germany Morrison , Antoine Nonclercq , Riëm El Tahry","doi":"10.1016/j.clinph.2025.01.006","DOIUrl":"10.1016/j.clinph.2025.01.006","url":null,"abstract":"<div><h3>Purpose</h3><div>The Locus Coeruleus (LC) plays a vital role by releasing norepinephrine, which contributes to the antiepileptic effects of Vagus Nerve Stimulation (VNS). LC activity also influences pupil dilation. Investigating VNS dose-dependent Pupillary Dilation Response (PDR) may provide novel neurophysiological insights into therapeutic response and allow for an objective and personalized optimization of stimulation parameters.</div></div><div><h3>Methods</h3><div>Fourteen VNS-implanted patients (9 responders, 5 non-responders) treated for at least 6 months were retrospectively recruited. VNS intensities were adjusted from 0.25 mA to 2.25 mA, or to the highest tolerable level. Concurrently, we tracked pupil size in the left eye and gathered patients’ subjective perception scores. Individual curve fitting was used to explore the relationship between VNS intensity and PDR.</div></div><div><h3>Results</h3><div>PDR increased with stimulation intensity, particularly in responders. In 6 patients, an inverted U-shaped relationship between intensity and PDR was observed 2–3 s after stimulation onset. A significant interaction was found between VNS intensity and responder status, independent of subjective perception.</div></div><div><h3>Conclusions</h3><div>VNS induces a dose-dependent PDR, which differs between responders and non-responders. In nearly half the patients, the dose–response relationship was characterized by an inverted U-shape with a maximal VNS effect.</div></div><div><h3>Significance</h3><div>We propose VNS-induced PDR as a novel biomarker of VNS response.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 67-75"},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson’s disease

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-27 DOI: 10.1016/j.clinph.2025.01.005

Arnaldo Fim Neto , Fabio Godinho , Luiz Ricardo Trajano da Silva , Julia Baldi de Luccas , André Kazuo Takahata , Eberval Gadelha Figueiredo , Carlos Gilberto Carlotti Junior , Maria Sheila Guimarães Rocha , Diogo Coutinho Soriano

{"title":"Alpha and high beta subthalamic intermittent activity correlates with freezing of gait severity in Parkinson’s disease","authors":"Arnaldo Fim Neto , Fabio Godinho , Luiz Ricardo Trajano da Silva , Julia Baldi de Luccas , André Kazuo Takahata , Eberval Gadelha Figueiredo , Carlos Gilberto Carlotti Junior , Maria Sheila Guimarães Rocha , Diogo Coutinho Soriano","doi":"10.1016/j.clinph.2025.01.005","DOIUrl":"10.1016/j.clinph.2025.01.005","url":null,"abstract":"<div><div><strong>Introduction:</strong> Freezing of gait (FOG) is a disabling symptom that affects over half of Parkinson’s disease patients (PD) and hinders the ability to walk. Subthalamic nucleus (STN) deep brain stimulation (DBS) effectiveness in ameliorating the FOG remains controversial, lacking a reliable electrophysiological biomarker from local field potentials (LFP). <strong>Methods:</strong> The LFP-STN rhythms bandpower and dynamics were characterized at rest across groups in a cohort of 23 patients (14 with FOG, and 9 without, n-FOG). <strong>Results:</strong> FOG patients presented enhanced alpha bandpower (FOG <em>vs</em>. n-FOG: 0.331 ± 0.087 <em>vs</em>. 0.248 ± 0.089; p = 0.011) and intermittent (burst) alpha amplitude (FOG <em>vs</em>. n-FOG: 0.610 ± 0.068 <em>vs</em>. 0.524 ± 0.086; p = 0.005). Both intermittent alpha (r = 0.330, p = 0.046) and intermittent high beta amplitude (r = 0.415, p = 0.011) correlated with the FOG score. Alpha burst amplitude correlated with FOG severity (r = 0.479, p = 0.003), and high beta burst amplitude inversely correlated (r = −0.411, p = 0.014) with the performance-oriented mobility assessment (POMA) index. <strong>Conclusion:</strong> These results suggest that alpha and high beta subthalamic oscillations impact FOG symptoms. <strong>Significance:</strong> The investigation suggests potentially newer co-biomarkers of FOG to guide multi-rhythm paradigms in DBS treatment.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 51-60"},"PeriodicalIF":3.7,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A novel TMS framework for assessing neurophysiological recovery at the subacute stage after stroke

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-24 DOI: 10.1016/j.clinph.2025.01.010

Maxine J. Shanks , John Cirillo , Cathy M. Stinear , Winston D. Byblow

{"title":"A novel TMS framework for assessing neurophysiological recovery at the subacute stage after stroke","authors":"Maxine J. Shanks , John Cirillo , Cathy M. Stinear , Winston D. Byblow","doi":"10.1016/j.clinph.2025.01.010","DOIUrl":"10.1016/j.clinph.2025.01.010","url":null,"abstract":"<div><h3>Objective</h3><div>To use peri-threshold transcranial magnetic stimulation (TMS) intensities to elicit motor evoked potentials (MEPs) during the subacute stage after stroke and assess their association with upper limb motor recovery.</div></div><div><h3>Methods</h3><div>Twenty-five MEP+ patients participated in three sessions at 1, 3, and 6 months post-stroke. Single-pulse TMS across a range of stimulation intensities was used to elicit MEPs in four muscles of the paretic and non-paretic upper limb. At each timepoint, threshold matrices were constructed based on MEP amplitude and persistence. A matrix element was suprathreshold if five out of ten stimulations elicited MEPs ≥ 50 μV. A subthreshold element produced MEPs below this criterion. Dexterity was assessed using the nine hole peg test.</div></div><div><h3>Results</h3><div>There were fewer suprathreshold, and more subthreshold elements on the paretic compared to the non-paretic side. The number of suprathreshold elements on the paretic side increased between 1 and 6 months post-stroke. Neither sub- nor supra-threshold elements were associated with dexterity recovery.</div></div><div><h3>Conclusion</h3><div>The proportion of sub- and supra-threshold elements reflect neurophysiological recovery during the subacute stage after stroke. A threshold matrix framework can identify patients with stable versus dynamic neurophysiology post-stroke.</div></div><div><h3>Significance</h3><div>A compositional analysis framework can quantify neurophysiological recovery after stroke.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 82-94"},"PeriodicalIF":3.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Brain network modulation in response to directional and Non-Directional Cues: Insights from EEG connectivity and graph theory

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-24 DOI: 10.1016/j.clinph.2025.01.007

Fabrizio Vecchio , Francesca Miraglia , Chiara Pappalettera , Paolo Maria Rossini

{"title":"Brain network modulation in response to directional and Non-Directional Cues: Insights from EEG connectivity and graph theory","authors":"Fabrizio Vecchio , Francesca Miraglia , Chiara Pappalettera , Paolo Maria Rossini","doi":"10.1016/j.clinph.2025.01.007","DOIUrl":"10.1016/j.clinph.2025.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>Directional cues have a profound impact on cognitive processes and behavior, and studying the involved brain networks can provide insights into their processing. This research aimed to investigate the neural network modulation associated with cognitive processing after the administration of directional cues using connectivity and graph theory.</div></div><div><h3>Methods</h3><div>Twenty healthy volunteers were enrolled and underwent EEG recording while they were asked to perform a visuomotor task, such as directional (DS) and non-directional (nDS). From EEG data, network parameters such as Small-World (SW) and Lagged linear connectivity across different EEG frequency bands were evaluated, analyzing the response to DS and nDS.</div></div><div><h3>Results</h3><div>The results revealed significant differences in the SW index, particularly in the Alpha 1 band, where participants exhibited a higher SW index when presented with DS compared to nDS. Moreover, the analysis of Alpha 1 band Lagged linear connectivity revealed close to statistically significant differences predominantly in the frontal and central regions.</div></div><div><h3>Conclusions</h3><div>This research contributes to our understanding of the neural mechanisms underlying the processing of directional cues.</div></div><div><h3>Significance</h3><div>It has potential implications for rehabilitation settings, for example in the rehabilitation of visual dysfunction and motor impairment following a stroke, by optimizing cognitive processing to enhance functional outcomes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 146-153"},"PeriodicalIF":3.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning-based algorithm of drug-resistant prediction in newly diagnosed patients with temporal lobe epilepsy

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-24 DOI: 10.1016/j.clinph.2025.01.008

Lingyan Mao , Gaoxing Zheng , Yang Cai , Wenyi Luo , Yijun Zhang , Kuidong Wu , Jing Ding , Xin Wang

{"title":"Machine learning-based algorithm of drug-resistant prediction in newly diagnosed patients with temporal lobe epilepsy","authors":"Lingyan Mao , Gaoxing Zheng , Yang Cai , Wenyi Luo , Yijun Zhang , Kuidong Wu , Jing Ding , Xin Wang","doi":"10.1016/j.clinph.2025.01.008","DOIUrl":"10.1016/j.clinph.2025.01.008","url":null,"abstract":"<div><h3>Objectives</h3><div>To develop a predicted algorithm for drug-resistant epilepsy (DRE) in newly diagnosed temporal lobe epilepsy (TLE) patients.</div></div><div><h3>Methods</h3><div>A total of 139 newly diagnosed TLE patients were prospectively enrolled, and long-term video EEG monitoring was recorded. Clinical evaluations, including seizure frequency and antiseizure medications (ASMs) usage, were collected and prospectively followed up for 24 months. Interictal EEG data were used for feature extraction, identifying 216 EEG network features. Traditional machine learning and ensemble learning techniques were employed to predict DRE outcomes.</div></div><div><h3>Results</h3><div>Over two years, TLE patients with DRE exhibited significant EEG differences, particularly in frontotemporal θ-band networks, characterized by increased connectivity metrics such as phase lag index (<em>P</em> = 0.000), etc. The predictive algorithm based on EEG features achieved accuracies between 59.2 %-84.6 % (AUC: 0.60–0.87). When compared to the whole brain, EEG features of the frontotemporal network showed improved classification performance in Naïve Bayes (<em>P</em> = 0.032), Tree Bagger (<em>P</em> = 0.021), and Subspace Discriminant (<em>P</em> = 0.022) models. The ensemble learning technique (Tree Bagger) delivered the best prediction results, achieving 91.5 % accuracy, 97 % sensitivity, 81 % specificity, and AUC of 0.92.</div></div><div><h3>Conclusions</h3><div>Increased frontotemporal EEG connectivity was observed in TLE patients with 2-year DRE. A predictive model based on routine EEG provides an accessible method for forecasting ASMs efficacy.</div></div><div><h3>Significance</h3><div>This study highlights the clinical utility of EEG-based algorithms in identifying DRE early, aiding personalized treatment strategies and improving patient outcomes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 154-163"},"PeriodicalIF":3.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-24 DOI: 10.1016/j.clinph.2025.01.009

Rodrigo Alberto Gonzalez-Montealegre , Alfredis González-Hernández , Jasmin Bonilla-Santos , Dorian Yisela Cala-Martínez , Mario Alfredo Parra

{"title":"Electrophysiological correlates of visual short-term memory binding deficits in community-dwelling seniors at risk of dementia","authors":"Rodrigo Alberto Gonzalez-Montealegre , Alfredis González-Hernández , Jasmin Bonilla-Santos , Dorian Yisela Cala-Martínez , Mario Alfredo Parra","doi":"10.1016/j.clinph.2025.01.009","DOIUrl":"10.1016/j.clinph.2025.01.009","url":null,"abstract":"<div><h3>Background</h3><div>Visual Short-Term Memory Binding (VSTMB) is a preclinical marker of Alzheimer’s disease (AD). Reduced early event-related potentials (ERPs) (100–250 ms) over fronto-central (FC) and parieto-occipital (PO) regions have been reported in patients with Mild Cognitive Impairment (MCI) seen in the clinic. We investigated such ERPs in a larger sample of community-dwelling older adults who had not sought medical advice.</div></div><div><h3>Methods</h3><div>Participants (n = 215) were assessed with a neuropsychological battery and the VSTMB Task. The latter assessed the ability to detect changes between two consecutive arrays of shapes or colored shapes (the Binding condition). Time-locked EEG signals were collected during the task.</div></div><div><h3>Results</h3><div>Those who met the MCI criteria (n = 108) showed binding impairment. ERP analyses revealed significant Group x Time Windows interactions. Early ERP showed reduced neural recruitment (MCI < healthy controls (HC)) over the right FC regions, left PO, and right centro-parietal (CP) regions during Binding encoding, and over PO regions bilaterally and left FC during retrieval. Late ERP showed increased neural recruitment (MCI > HC) on left FC and PO regions during retrieval.</div></div><div><h3>Conclusions</h3><div>Hyper-recruitment may reflect functional reorganization aimed at behavioral compensation in the early stages of MCI. The role of such amplitude shifts as pointers of transition points in the AD continuum needs further investigation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 227-239"},"PeriodicalIF":3.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Increase in EEG functional connectivity and power during wakefulness in self-limited epilepsy with centrotemporal spikes

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-24 DOI: 10.1016/j.clinph.2024.12.028

David Garnica-Agudelo , Stuart D.W. Smith , Daniel van de Velden , Dagmar Weise , Knut Brockmann , Niels K. Focke

{"title":"Increase in EEG functional connectivity and power during wakefulness in self-limited epilepsy with centrotemporal spikes","authors":"David Garnica-Agudelo , Stuart D.W. Smith , Daniel van de Velden , Dagmar Weise , Knut Brockmann , Niels K. Focke","doi":"10.1016/j.clinph.2024.12.028","DOIUrl":"10.1016/j.clinph.2024.12.028","url":null,"abstract":"<div><h3>Objective</h3><div>Examine power and functional connectivity (FC) in children with Self-limited Epilepsy with Centrotemporal Spikes (SeLECTS) during resting-state.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed 37 children with SeLECTS and 34 matched controls. Fifty seconds of awake resting-state source-reconstructed EEG per subject were selected to compare groups using power and weighted phase lag index (wPLI). We compared patients’ epochs with and without interictal epileptiform discharges (IEDs) between each other and to controls’ epochs. Additionally, we compared epochs without IEDs from recent-onset SeLECTS and longer-duration SeLECTS patients between each other and to controls’ epochs.</div></div><div><h3>Results</h3><div>SeLECTS patients demonstrated widespread and significant power increases compared to controls. FC analyses of epochs without IEDs revealed predominantly left-sided increases in the beta band and decreases in theta band compared to controls. In epochs with IEDs, there were further FC increases in the delta band compared to epochs without IEDs located in bilateral fronto-centrotemporal regions. Patients with recent-onset SeLECTS had significant bilateral temporo-parietal FC increases in beta1 relative to controls. Patients with longer-duration SeLECTS showed significant left centrotemporal FC increases in beta and bilateral centrotemporal decreases in delta compared to controls.</div></div><div><h3>Conclusions</h3><div>SeLECTS patients exhibit atypical power and FC patterns during wakefulness, even in epochs without IEDs. These were more pronounced in recent-onset cases and epochs with IEDs, suggesting an association between IEDs frequency and the disease course.</div></div><div><h3>Significance</h3><div>Studying power and FC abnormalities in children with SeLECTS provides insight into disease evolution and the influence of IEDs on brain networks.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 107-123"},"PeriodicalIF":3.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143074324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG signature orchestrating expression of ictal behavior in mesial temporal lobe epilepsy

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-24 DOI: 10.1016/j.clinph.2024.12.029

Chenmin He , Wenhan Hu , Kai Xiong , Lingqi Ye , Hongyi Ye , Lingli Hu , Yi Ge , Meng Wang , Cong Chen , Bo Jin , Cenglin Xu , Yi Wang , Sha Xu , Yao Ding , Yingcai Wu , Hongjie Jiang , Junming Zhu , Meiping Ding , Wenling Li , Kai Zhang , Shan Wang

{"title":"EEG signature orchestrating expression of ictal behavior in mesial temporal lobe epilepsy","authors":"Chenmin He , Wenhan Hu , Kai Xiong , Lingqi Ye , Hongyi Ye , Lingli Hu , Yi Ge , Meng Wang , Cong Chen , Bo Jin , Cenglin Xu , Yi Wang , Sha Xu , Yao Ding , Yingcai Wu , Hongjie Jiang , Junming Zhu , Meiping Ding , Wenling Li , Kai Zhang , Shan Wang","doi":"10.1016/j.clinph.2024.12.029","DOIUrl":"10.1016/j.clinph.2024.12.029","url":null,"abstract":"<div><h3>Objectives</h3><div>We investigated EEG features differentiating clinical seizures (CSs) from subclinical seizures (SCSs) to explore the mechanisms underlying the generation of ictal behavior in mesial temporal lobe epilepsy (mTLE).</div></div><div><h3>Methods</h3><div>Peri-ictal state of power spectral density (PSD) within seizure onset zone (SOZ) and propagation zone (PZ) were compared between SCSs and CSs. Functional connectivity was analyzed using the nonlinear correlation coefficient <em>h</em><sup>2</sup>, outgoing links (OUT) and ingoing links (IN). The EEG epochs of CSs-early part and SCSs were equally divided into four segments to reveal dynamic EEG changes.</div></div><div><h3>Results</h3><div>During pre-ictal state, PSD at 30–80 Hz in SOZ was higher in CSs than in SCSs. The preictal OUT and IN values in SOZ at 30–80 Hz were greater in CSs than in SCSs. During CSs-early part, PSD displayed an initial increase in SOZ but a late increase in PZ, with enhanced high-frequency activity in temporal regions and increased low-frequency activity in insula.</div></div><div><h3>Conclusion</h3><div>The enhanced pre-ictal gamma activity within the epileptic network was able to distinguish CSs from SCSs. The unique temporospatial alterations within the epileptic network drive the expression of ictal behavior in mTLE.</div></div><div><h3>Significance</h3><div>The distinct EEG features between SCSs and CSs offer transformative insights into the mechanisms driving ictal behavior.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 124-132"},"PeriodicalIF":3.7,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143159706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rhythmic EEG patterns: The oldest idea in the EEG world, but without an obvious definition

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-01-23 DOI: 10.1016/j.clinph.2024.12.024

Philippe Gélisse , William O. Tatum , Arielle Crespel , Peter W. Kaplan

{"title":"Rhythmic EEG patterns: The oldest idea in the EEG world, but without an obvious definition","authors":"Philippe Gélisse , William O. Tatum , Arielle Crespel , Peter W. Kaplan","doi":"10.1016/j.clinph.2024.12.024","DOIUrl":"10.1016/j.clinph.2024.12.024","url":null,"abstract":"<div><div>The word “rhythmic” was quickly introduced in the vocabulary of the electroencephalographers with the discovery of the alpha rhythm and typical discharges of spike-and-waves at 3 Hz in childhood absence epilepsy, but without any definition until recently. In its last revision (2017), the International Federation of Clinical Neurophysiology proposed a specific definition. The word “rhythmic” is “applied to regular waves occurring at a constant period and of relatively uniform morphology.” Unfortunately, there is a serious problem of ambiguity as this definition exactly corresponds in science to the definition of a periodic function (periodic waveform). This definition of regular patterns at constant intervals (constant period) can be applied to physiological rhythms such as alpha and mu rhythms but also to unusual rhythms such as rhythmic theta bursts of drowsiness. It can also be used to describe EEG patterns, such as frontal/temporal/occipital intermittent rhythmic activities or generalized rhythmic delta activities. Except with typical absence seizures, this definition cannot be used to describe most epileptic seizures and absence status epilepticus. Identifying ’periodic’ versus ’rhythmic’ features is crucial when analyzing an EEG in critically ill patients. The importance lies in a balanced approach that frequently promotes an interpretation of an acute encephalopathy when referring to diffuse periodic EEG patterns, and status epilepticus for unreactive bilateral rhythmic patterns. To include seizures and status epilepticus in the definition of rhythmic patterns, we suggest a more “dynamic” approach in addition to the regular waves at constant intervals without interdischarge intervals between waveforms. For the observed rhythmic patterns, we propose: <em>repetition of consecutive waves with, in case of a variation in the pattern, a dynamic approach to these waveforms.</em> Dynamic means spatiotemporal evolution of the patterns.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"171 ","pages":"Pages 76-81"},"PeriodicalIF":3.7,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0