Clinical Neurophysiology最新文献_第6页

The integrity of double-blinding of continuous theta-burst stimulation targeting the supplementary motor area in a within-subjects design 以辅助运动区域为目标的连续脉冲刺激双盲实验的完整性。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-17 DOI: 10.1016/j.clinph.2025.2111482

Melker Hagsäter , Jonatan Malmros , Jonas Persson , Jonas Jester-Broms , Robert Bodén

引用次数: 0

Is EEG useful in predicting neurotoxicity and outcomes related to chimeric antigen receptor (CAR) T-cell therapy? 脑电图在预测嵌合抗原受体（CAR） t细胞治疗相关的神经毒性和预后方面有用吗？

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-16 DOI: 10.1016/j.clinph.2025.2111484

Brin E. Freund , Adrian Safa , Filippo Emanuele Colella , Guido Chiriboga , Toni Betiku , Andy Shar , Cornelia Drees , Jeffrey Britton , Anteneh M. Feyissa , William O. Tatum

{"title":"Is EEG useful in predicting neurotoxicity and outcomes related to chimeric antigen receptor (CAR) T-cell therapy?","authors":"Brin E. Freund , Adrian Safa , Filippo Emanuele Colella , Guido Chiriboga , Toni Betiku , Andy Shar , Cornelia Drees , Jeffrey Britton , Anteneh M. Feyissa , William O. Tatum","doi":"10.1016/j.clinph.2025.2111484","DOIUrl":"10.1016/j.clinph.2025.2111484","url":null,"abstract":"<div><h3>Background</h3><div>Chimeric antigen receptor (CAR) T-cell therapy revolutionized cancer treatment, though has potential for neurotoxicity (immune effector cell-associated neurotoxicity syndrome, ICANS). EEG has been proposed as a predictive and prognostic tool in ICANS.</div></div><div><h3>Objective</h3><div>Evaluate pre-treatment EEG, neuroimaging, and clinical features in predicting ICANS, and EEG in prognosis in ICANS.</div></div><div><h3>Methods</h3><div>Retrospective multicenter study involving adult patients who underwent CAR T-cell therapy at Mayo Clinic Florida, Minnesota, and Arizona between October 2019 and July 2024. Univariable, multivariable and survival analyses were performed.</div></div><div><h3>Results</h3><div>We included 207 patients (111 female). Pre-treatment EEG was performed in 50.2 % of patients. Multivariable analysis of EEG, imaging, and clinical data demonstrated older age (roughly 1 % increased odds per 1 year of increased age, p = 0.006) and generalized slowing on pre-treatment EEG being associated with ICANS (p = 0.021). There were no factors predictive of hospital duration or survival in ICANS using multivariable analysis. Patients with ICANS had longer hospitalization (p < 0.001) and were less likely to survive at 12- and 24-months (p = 0.001, p < 0.001 respectively).</div></div><div><h3>Conclusion</h3><div>ICANS is associated with longer hospitalization and worse survival. ICANS risk increases with older age. Generalized slowing on pre-treatment EEG may identify patients at risk of ICANS.</div></div><div><h3>Significance</h3><div>ICANS is associated with worse outcomes and may be predicted by pre-treatment EEG and older age.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111484"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Postoperative epileptiform discharges predict seizure outcomes in pediatric low-grade developmental and epilepsy associated tumors 术后癫痫样放电预测小儿低度发育性和癫痫相关肿瘤的发作结局

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-02-01 Epub Date: 2025-12-04 DOI: 10.1016/j.clinph.2025.2111462

Florian Mayer , Johannes Zielke , Birgit Pimpel , Katharina Moser , Clara Köller , Sarah Glatter , Gregor Kasprian , Amedeo A. Azizi , Johannes Gojo , Matthias Tomschik , Christian Dorfer , Karl Roessler , Martha Feucht

{"title":"Postoperative epileptiform discharges predict seizure outcomes in pediatric low-grade developmental and epilepsy associated tumors","authors":"Florian Mayer , Johannes Zielke , Birgit Pimpel , Katharina Moser , Clara Köller , Sarah Glatter , Gregor Kasprian , Amedeo A. Azizi , Johannes Gojo , Matthias Tomschik , Christian Dorfer , Karl Roessler , Martha Feucht","doi":"10.1016/j.clinph.2025.2111462","DOIUrl":"10.1016/j.clinph.2025.2111462","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the prognostic value of interictal epileptiform discharges (iEDs) on postoperative video-EEG in children and adolescents undergoing epilepsy surgery for low-grade developmental and epilepsy-associated tumors (LEATs).</div></div><div><h3>Methods</h3><div>This retrospective single-center study analyzed prospectively collected pre- and postoperative EEG data from pediatric LEAT patients. Associations between iED characteristics and seizure outcomes ≥ 24 months after surgery were examined.</div></div><div><h3>Results</h3><div>Fifty-nine patients with a median postoperative follow-up of 59.0 months (IQR: 36.0–118.0) were included. Univariate analysis identified the presence of a secondary iED focus at 3 months (p = 0.04), persistent iEDs at 12 months (p = 0.007), and a ≥ 50 % increase in iED frequency over time (p = 0.009) as predictors of unfavorable seizure outcomes. Multivariate analysis confirmed that a ≥ 50 % increase in iED frequency within the first 12 months post-surgery was independently associated with unfavorable outcomes (OR: 16.2, 95 % CI: 1.2–555.0, p = 0.037).</div></div><div><h3>Conclusions</h3><div>Postoperative iEDs, particularly their evolution over time, are valuable predictors of long-term seizure outcomes following LEAT surgery.</div></div><div><h3>Significance</h3><div>Prognostic models for seizure outcomes in LEAT patients should not only include clinical, radiological and surgical characteristics, but also presence and progression of iEDs in postoperative EEGs.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111462"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145697914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of frequency on dual target deep brain stimulation 频率对双靶深部脑刺激的影响

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/j.clinph.2025.2111467

Rocio Rodriguez Capilla , Aislinn M. Hurley , Karthik Kumaravelu , Jennifer J. Peters , Hui-Jie Lee , Dennis A. Turner , Warren M. Grill , Stephen L. Schmidt

{"title":"Effect of frequency on dual target deep brain stimulation","authors":"Rocio Rodriguez Capilla , Aislinn M. Hurley , Karthik Kumaravelu , Jennifer J. Peters , Hui-Jie Lee , Dennis A. Turner , Warren M. Grill , Stephen L. Schmidt","doi":"10.1016/j.clinph.2025.2111467","DOIUrl":"10.1016/j.clinph.2025.2111467","url":null,"abstract":"<div><h3>Background</h3><div>Deep brain stimulation reduces the motor symptoms of Parkinson’s disease (PD). Dual target deep brain stimulation (DT DBS) may better reduce symptoms and minimize side effects than single target, but the optimal parameters of DT DBS are unknown.</div></div><div><h3>Objective</h3><div>To quantify the frequency response of DT DBS on bradykinesia and beta oscillations, and to explore intrahemispheric pulse delay shifts as a means to reduce total energy delivered.</div></div><div><h3>Methods</h3><div>We applied DT DBS using the Summit RC + S in six participants with PD, varying DBS frequency. We further examined the effects of frequency in a biophysical model.</div></div><div><h3>Results</h3><div>DT DBS at 50 Hz was effective at reducing bradykinesia, whereas increasing DT DBS frequency up to 125 Hz also led to significantly lower beta power. This frequency effect on beta power was replicated in a biophysical model. The model suggested that 22 Hz DT DBS, with an intrahemispheric delay of 40 ms, can reduce beta power by 87 %.</div></div><div><h3>Conclusion</h3><div>This exploratory study (n = 6) suggests that 125 Hz DT DBS best reduced bradykinesia. However, low frequency DBS with an appropriate intrahemispheric delay could also improve symptom relief.</div></div><div><h3>Significance</h3><div>Both 125 Hz and tailored low-frequency DT DBS may achieve equivalent symptomatic control of PD symptoms.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111467"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Routine EEG with quantitative analysis to detect delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage 常规脑电图定量分析检测动脉瘤性蛛网膜下腔出血迟发性脑缺血。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/j.clinph.2025.2111449

Marina S. Cherchi , Miguel A. Hernández-Hernández , Javier Hernández-Cabello , Eduardo Torres Díez , Pedro Orizaola , Tetyana Stakhurska-Bilynska , Rubén Martín-Láez , José L. Fernández-Torre

{"title":"Routine EEG with quantitative analysis to detect delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage","authors":"Marina S. Cherchi , Miguel A. Hernández-Hernández , Javier Hernández-Cabello , Eduardo Torres Díez , Pedro Orizaola , Tetyana Stakhurska-Bilynska , Rubén Martín-Láez , José L. Fernández-Torre","doi":"10.1016/j.clinph.2025.2111449","DOIUrl":"10.1016/j.clinph.2025.2111449","url":null,"abstract":"<div><h3>Objective</h3><div>To assess the ability of routine electroencephalography (rEEG) to predict delayed cerebral ischemia (DCI) in aneurysmal subarachnoid hemorrhage (aSAH).</div></div><div><h3>Methods</h3><div>Single-center prospective study including adult patients with aSAH. Two rEEG recordings with quantitative analysis and transcranial Doppler sonography (TCD) were performed, within the first 72 h (EEG1 and TCD1) and between days 4–7 (EEG2 and TCD2). Multivariate logistic regression was performed to identify DCI predictors.</div></div><div><h3>Results</h3><div>Seventeen (25.4 %) of 67 patients developed DCI. In qualitative analysis, no patient with a normal EEG1 had DCI, while in EEG2, the absence of bilateral posterior alpha rhythm was more frequently observed in patients with DCI (52.9 % vs 20 %; p = 0.009). Quantitative EEG2 analysis revealed significantly higher total, delta, and theta power in DCI patients, with lower alpha–beta/theta-delta ratio and edge. Delta power ≥ 4.5 μV in EEG2 showed higher sensitivity than vasospasm on TCD2 but lower specificity. Age (OR 1.08; p = 0.04), vasospasm on TCD2 (OR 41.01; p = 0.003) and delta power ≥ 4.5 μV in EEG2 (OR 4.30; p = 0.06) were independent predictors of DCI.</div></div><div><h3>Conclusions</h3><div>rEEG with quantitative analysis is a useful tool for predicting DCI.</div></div><div><h3>Significance</h3><div>Integration of rEEG and TCD may improve detection of DCI in aSAH patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111449"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145602517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigemino-cervical reflex can be recorded simultaneously with other trigeminal reflexes after V3 stimulation under general anesthesia 全身麻醉V3刺激后三叉-颈反射可与其他三叉反射同时记录。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-20 DOI: 10.1016/j.clinph.2025.2111448

Denise Lima Medeiros de Melo, Dayanne Rodrigues da Cunha Alves Bento Oliveira, Patricia Lago dos Santos Madureira

引用次数: 0

Quantitative intraoperative lateral spread response amplitudes in hemifacial Spasm: Associations with vascular burden 术中面肌痉挛的定量侧展反应振幅：与血管负荷的关系

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-12-01 DOI: 10.1016/j.clinph.2025.2111466

Minsoo Kim , Soung Wook Park , Hyun Seok Lee , Sang-Ku Park , Kwan Park

{"title":"Quantitative intraoperative lateral spread response amplitudes in hemifacial Spasm: Associations with vascular burden","authors":"Minsoo Kim , Soung Wook Park , Hyun Seok Lee , Sang-Ku Park , Kwan Park","doi":"10.1016/j.clinph.2025.2111466","DOIUrl":"10.1016/j.clinph.2025.2111466","url":null,"abstract":"<div><h3>Objective</h3><div>To determine whether intraoperative lateral spread response (LSR) amplitudes reflect vascular burden and configuration in hemifacial spasm.</div></div><div><h3>Methods</h3><div>We retrospectively reviewed consecutive microvascular decompressions at a single center. LSR I (mentalis) and LSR II (frontalis) were recorded using a standardized protocol. The primary exposure was arterial vessel count (single vs. multiple); vein-only cases were exploratory owing to imbalance. Amplitudes and derived indices (I/II ratio, I–II difference) were compared using variance-aware parametric and nonparametric tests.</div></div><div><h3>Results</h3><div>LSRs were obtained in most patients. LSR I exceeded LSR II with a significant paired effect. Arterial burden showed a graded pattern in LSR I, with higher amplitudes in multiple-vessel compression; however, differences across vessels counts were not significant after adjustment. No differences were observed for LSR II. Derived indices better reflected vascular burden, showing significant contrasts where raw amplitudes did not, including single-versus-multiple comparisons. Vein-only cases appeared lower but remained exploratory.</div></div><div><h3>Conclusions</h3><div>Intraoperative LSR amplitudes, especially at the mentalis muscle, reflect arterial burden, and derived indices improve discrimination. Findings support amplitude-based monitoring, with multicenter studies needed to confirm underlying mechanisms and predictive utility.</div></div><div><h3>Significance</h3><div>LSR monitoring offers a practical marker of vascular burden, potentially guiding surgical decisions and improving outcomes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"182 ","pages":"Article 2111466"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145682018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ipsilateral and contralateral cortical control of the external oblique muscles revealed by TMS 经颅磁刺激揭示的外斜肌同侧和对侧皮质控制

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-10-24 DOI: 10.1016/j.clinph.2025.2111400

Ryoji Miyano , Yuichiro Shirota , Satoshi Kodama , Tatsushi Toda , Masashi Hamada

{"title":"Ipsilateral and contralateral cortical control of the external oblique muscles revealed by TMS","authors":"Ryoji Miyano , Yuichiro Shirota , Satoshi Kodama , Tatsushi Toda , Masashi Hamada","doi":"10.1016/j.clinph.2025.2111400","DOIUrl":"10.1016/j.clinph.2025.2111400","url":null,"abstract":"<div><h3>Objectives</h3><div>Transcranial magnetic stimulation (TMS) is used widely to explore human motor function. This study was conducted to investigate the differences between contralateral and ipsilateral cortical control on trunk muscles for eliciting contralateral and ipsilateral motor evoked potentials (MEPs) in the external oblique muscles.</div></div><div><h3>Methods</h3><div>Twenty healthy participants were examined: 10 younger and 10 older adults. They underwent TMS to locate contralateral and ipsilateral hot spots. For the identified hot spots in the younger group, the coil was positioned in eight orientations, each separated by 45 degrees, to measure active motor threshold (AMT) and onset latencies.</div></div><div><h3>Results</h3><div>Contralateral MEPs were obtained from all participants, whereas ipsilateral MEPs were detected in 14 out of 20 participants. The ipsilateral hot spots were located more laterally from Cz (<em>p</em> < 0.05). Coil orientation that induced an antero-medially directed current in the brain produced the shortest onset latency and lowest AMT for both stimulations. However contralateral MEPs required lower AMT and exhibited shorter onset latency than ipsilateral MEPs (<em>p</em> < 0.05).</div></div><div><h3>Conclusions</h3><div>Ipsilateral motor pathways of the external oblique muscles have physiological features unlike those of contralateral motor pathways.</div></div><div><h3>Significance</h3><div>These findings suggest differential cortical control between contralateral and ipsilateral pathways in trunk muscles and provide bases for additional investigations into ipsilateral motor control.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111400"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145435576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spike density in children with self-limited focal epilepsies affects memory performance and slow wave-spindle coupling during sleep 自限性局灶性癫痫儿童的脑电波密度影响睡眠时的记忆表现和慢波-纺锤体耦合

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-01 DOI: 10.1016/j.clinph.2025.2111406

Elena C. Schmidt , Sarah Storz , Jelena Skorucak , Georgia Ramantani , Bigna K. Bölsterli , Sara Fattinger , Reto Huber

{"title":"Spike density in children with self-limited focal epilepsies affects memory performance and slow wave-spindle coupling during sleep","authors":"Elena C. Schmidt , Sarah Storz , Jelena Skorucak , Georgia Ramantani , Bigna K. Bölsterli , Sara Fattinger , Reto Huber","doi":"10.1016/j.clinph.2025.2111406","DOIUrl":"10.1016/j.clinph.2025.2111406","url":null,"abstract":"<div><h3>Objective</h3><div>Precise coupling of slow waves and spindles during non-rapid eye movement (NREM) sleep is crucial for memory consolidation. Children with self-limited focal epilepsies (SelFE) show epileptic spike waves during NREM sleep and often have impaired sleep-related memory. We investigated for the first time how spikes affect slow wave–spindle coupling and its impact on overnight memory.</div></div><div><h3>Methods</h3><div>Fourteen SelFE patients (mean age: 8.7 years) underwent overnight high-density EEG (128 channels) and completed a word-pair memory task before and after sleep. Spikes, spindles, and slow waves were automatically detected. Coupling precision was defined as the ratio of spindles during the ascending versus descending phase of the slow wave. Cluster-corrected topographical correlations examined relationships between spike density, coupling precision, and memory outcomes.</div></div><div><h3>Results</h3><div>Higher spike density was associated with poorer memory performance in a left centro-parietal region. Better memory was linked to greater coupling precision during the ascending phase in a left centro-frontal area. Increased spike density also correlated with reduced coupling precision in a central region.</div></div><div><h3>Conclusion</h3><div>Spikes may disrupt thalamocortical activity, impairing slow wave–spindle coupling and memory consolidation.</div></div><div><h3>Significance</h3><div>These findings suggest a mechanistic link between epileptic sleep activity and cognitive deficits in SelFE.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"181 ","pages":"Article 2111406"},"PeriodicalIF":3.6,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465095","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

C3-C4 transcranial direct current stimulation montage stimulates lower limb region better than C1-C2 montage C3-C4经颅直流电刺激蒙太奇对下肢区域的刺激优于C1-C2蒙太奇

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2026-01-01 Epub Date: 2025-11-05 DOI: 10.1016/j.clinph.2025.2111416

Ziping Huang , Riki Shimizu , Saurabh R. Sinha , Derek Southwell , Charalambos C. Charalambous , Angel V. Peterchev , Wuwei Feng , Pratik Y. Chhatbar , Taewon Kim

引用次数: 0