Clinical Neurophysiology最新文献_第2页

Reply to: Commentary: Tonic stretch reflex threshold as a measure of disordered motor control and spasticity - A critical review.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-17 DOI: 10.1016/j.clinph.2024.12.017

Mindy F Levin, Daniele Piscitelli, Joy Khayat

引用次数: 0

Experience with salbutamol treatment in a family with congenital myasthenia due to CHRNE mutation.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-17 DOI: 10.1016/j.clinph.2024.12.010

Didem Tezen, Esra Koçhan Kızılkılıç, Nursena Erener, Zakhiriddin Khojakulov, Veysi Demirbilek, Ayşe Nazlı Başak

引用次数: 0

An objective and sensitive electrophysiological marker of word semantic categorization impairment in Alzheimer's disease.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-16 DOI: 10.1016/j.clinph.2024.12.018

Justine David, Lisa Quenon, Bernard Hanseeuw, Adrian Ivanoiu, Angélique Volfart, Laurent Koessler, Bruno Rossion

{"title":"An objective and sensitive electrophysiological marker of word semantic categorization impairment in Alzheimer's disease.","authors":"Justine David, Lisa Quenon, Bernard Hanseeuw, Adrian Ivanoiu, Angélique Volfart, Laurent Koessler, Bruno Rossion","doi":"10.1016/j.clinph.2024.12.018","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.018","url":null,"abstract":"Objective: Combining electroencephalographic (EEG) recording and fast periodic visual stimulation (FPVS) to provide an implicit, objective and sensitive electrophysiological measure of semantic word categorization impairment in Alzheimer's Disease (AD).Methods: Twenty-five AD patients and 25 matched elderly healthy controls were tested with a validated FPVS-EEG paradigm in which different written words of the same semantic category (cities) appear at a fixed frequency of 4 words per second (4 Hz) for 70 seconds. Words from a different semantic category (animal) appear every 4 stimuli (i.e., 1 Hz).Results: Frequency domain EEG analysis showed a robust response objectively identified at specific 1 Hz harmonics over the left occipito-temporal cortex for healthy controls, indexing automatic semantic categorization. However, only a negligible response, less than 25 % of healthy controls', was found in AD patients, this response being inversely correlated with the amount of Tau protein in the cerebrospinal fluid. The significant group difference was maximal when including an additional left central region, with only 2.5 min of testing providing a significant group difference.Conclusion: A reduced semantic word categorisation EEG amplitude rapidly differentiates AD patients from healthy controls.Significance: FPVS-EEG provides a valuable electrophysiological index of semantic categorization impairment in AD.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"98-109"},"PeriodicalIF":3.7,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral nerve excitability abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with histopathological analysis.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-14 DOI: 10.1016/j.clinph.2024.12.013

Yusuke Osaki, Hiroyuki Nodera, Ryota Sato, Shotaro Haji, Koji Fujita, Ryosuke Miyamoto, Kohei Muto, Hiroki Yamazaki, Hiroyuki Morino, Takashi Kanda, Shigeo Murayama, Ryuji Kaji, Yuishin Izumi

{"title":"Peripheral nerve excitability abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with histopathological analysis.","authors":"Yusuke Osaki, Hiroyuki Nodera, Ryota Sato, Shotaro Haji, Koji Fujita, Ryosuke Miyamoto, Kohei Muto, Hiroki Yamazaki, Hiroyuki Morino, Takashi Kanda, Shigeo Murayama, Ryuji Kaji, Yuishin Izumi","doi":"10.1016/j.clinph.2024.12.013","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.013","url":null,"abstract":"Objective: Neuronal Intranuclear Inclusion Disease (NIID) is a neurodegenerative disease affecting the central and peripheral nerves. We aimed to assess the pathophysiological features of peripheral nerve dysfunction in NIID.Methods: We observed six unrelated NIID patients through clinical records, nerve conduction studies, and multiple measures of motor nerve excitability. Additionally, we reviewed one NIID patientt who underwent a nerve biopsy. Control measures were obtained from 22 age-matched normal subjects.Results: The NIID patients exhibited mild conduction slowing and distinct nerve excitability abnormalities, including a significant decrease in excitability through hyperpolarizing threshold electrotonus (TE) and increased overshoots in both depolarizing and hyperpolarizing conditions. Histopathology revealed thinly myelinated fibers and axonal degeneration. Mathematical modeling suggested that reduced leak conductance was the key factor contributing to the observed excitability changes.Conclusions: The findings indicate that NIID involves a complex interplay of axonal degeneration and myelin dysfunction, leading to unique peripheral nerve excitability changes. These results provide new insights into the pathophysiology of NIID.Significance: Nerve excitability testing offers insight into particular axonal excitability abnormalities especially combined with histopathologic studies.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"156-167"},"PeriodicalIF":3.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reorganization of pragmatic language networks in patients with temporal lobe epilepsy.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-14 DOI: 10.1016/j.clinph.2024.12.012

Bautista Elizalde Acevedo, Silvia Kochen, Lucy Alba-Ferrara, Mariana Bendersky

{"title":"Reorganization of pragmatic language networks in patients with temporal lobe epilepsy.","authors":"Bautista Elizalde Acevedo, Silvia Kochen, Lucy Alba-Ferrara, Mariana Bendersky","doi":"10.1016/j.clinph.2024.12.012","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.012","url":null,"abstract":"Objective: To investigate the neural networks involved in idiomatic expressions (IE) comprehension in healthy controls and patients with drug-resistant temporal lobe epilepsy (TLE), with a functional magnetic resonance imaging (fMRI) task.Methods: Thirty-two patients with TLE (left or right) and seventeen healthy controls were evaluated. Activated nodes in the fMRI task were defined as Regions of Interest (ROIs) for a posterior functional connectivity analysis.Results: All participants completed the task successfully. We found a bilateral fronto-temporal network, lateralized to the right, during IE processing in the overall sample. Compared to controls, patients additionally activated frontal, temporal, and insular areas in both hemispheres. Controls exhibited fewer connections but greater inhibitory connectivity, while the opposite (more connections and increased excitatory connectivity) occurred in patients. Compared to controls, TLE patients recruited additional brain areas on top of the expected bilateral frontotemporal network. The connectivity analysis revealed that controls exhibited more effective inhibitory connectivity, with more modular ROIs. In contrast, patients demonstrated greater excitatory connectivity.Conclusion: The results suggest compensatory neural recruitment in additional areas in TLE during IE comprehension.Significance: Exacerbated connections in TLE may reflect the need to recruit alternative regions, resulting in higher costs and lower efficiency of the neural network.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"194-205"},"PeriodicalIF":3.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between early life EEG and brain MRI in preterm infants: A systematic review.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-14 DOI: 10.1016/j.clinph.2024.12.014

Roos F Meijer, Xiaowan Wang, Inge M van Ooijen, Bauke van der Velde, Jeroen Dudink, Manon J N L Benders, Maria Luisa Tataranno

{"title":"The relationship between early life EEG and brain MRI in preterm infants: A systematic review.","authors":"Roos F Meijer, Xiaowan Wang, Inge M van Ooijen, Bauke van der Velde, Jeroen Dudink, Manon J N L Benders, Maria Luisa Tataranno","doi":"10.1016/j.clinph.2024.12.014","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.014","url":null,"abstract":"Objective: To systematically review the literature on the associations between electroencephalogram (EEG) and brain magnetic resonance imaging (MRI) measures in preterm infants (gestational age < 37 weeks).Methods: A comprehensive search was performed in PubMed and EMBASE databases up to February 12th, 2024. Non-relevant studies were eliminated following the PRISMA guidelines.Results: Ten out of 991 identified studies were included. Brain MRI metrics used in these studies include volumes, cortical features, microstructural integrity, visual assessments, and cerebral linear measurements. EEG parameters were classified as qualitative (Burdjalov maturity score, seizure burden, and background activity) or quantitative (discontinuity, spectral content, amplitude, and connectivity). Among them, discontinuity and the Burdjalov score were most frequently examined. Higher discontinuity was associated with reduced brain volume, cortical surface, microstructural integrity, and linear measurements. The Burdjalov score related to brain maturation qualitatively assessed on MRI. No other consistent correlations could be established due to the variability across studies.Conclusions: The reviewed studies utilized a variety of EEG and MRI measurements, while discontinuity and the Burdjalov score stood out as significant indicators of structural brain development.Significance: This review, for the first time, provides an extensive overview of EEG-MRI associations in preterm infants, potentially facilitating their clinical application.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"168-179"},"PeriodicalIF":3.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892602","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intermuscular coherence during co-contraction eliciting tasks as a biomarker for dystonia and GPi-DBS efficacy. 共同收缩诱发任务中的肌间连贯性是肌张力障碍和 GPi-DBS 疗效的生物标记。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-14 DOI: 10.1016/j.clinph.2024.12.011

S A J E A Lagerweij, J C van Zijl, M Smit, H Eggink, D L M Oterdoom, J M C van Dijk, M E van Egmond, J W Elting, M A J Tijssen

{"title":"Intermuscular coherence during co-contraction eliciting tasks as a biomarker for dystonia and GPi-DBS efficacy.","authors":"S A J E A Lagerweij, J C van Zijl, M Smit, H Eggink, D L M Oterdoom, J M C van Dijk, M E van Egmond, J W Elting, M A J Tijssen","doi":"10.1016/j.clinph.2024.12.011","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.011","url":null,"abstract":"Objective: Clinical rating scales often fail to capture the full spectrum of dystonic symptoms. Deep brain stimulation of the globus pallidus interna (GPi-DBS) effectively treats dystonia, but response variability necessitates a reliable biomarker. Intermuscular coherence (4-12 Hz) has been linked to abnormal activity in the cortico-basal ganglia-thalamo-cortical (CBGTC) loop and may serve as an objective measure of dystonia and GPi-DBS effectiveness.Methods: A retrospective cohort study included 12 dystonia patients undergoing GPi-DBS implantation. Clinical rating scales and a neurophysiological assessment were performed before and one year post-DBS. Coherence in the 4-12 Hz range was analyzed from electromyography (EMG) of antagonistic arm muscles. Comparisons were made between patients with and without arm dystonia, t-tests evaluated the differences between pre- and post-DBS, and correlations between coherence and clinical scales were performed.Results: Seven patients with arm dystonia appeared to have higher pre-operative intermuscular coherence compared to those without. Coherence was significantly decreased after GPi-DBS in the arm dystonia group. No strong correlations were found between coherence and clinical rating scales.Conclusion: Intermuscular coherence is present in dystonic muscles and decreases following GPi-DBS. Correlations with motor scores were inconclusive due to patient heterogeneity and ill-fitting clinical scales.Significance: Intermuscular coherence has potential to aid GPi-DBS patient selection and optimization but larger studies are needed to validate its use.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"70-79"},"PeriodicalIF":3.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Accurate determination of motor evoked potential amplitude in TMS: The impact of personal and experimental factors.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-14 DOI: 10.1016/j.clinph.2024.12.009

Marten Nuyts, Stefanie Verstraelen, Joana Frieske, Raf Meesen, Sybren Van Hoornweder

{"title":"Accurate determination of motor evoked potential amplitude in TMS: The impact of personal and experimental factors.","authors":"Marten Nuyts, Stefanie Verstraelen, Joana Frieske, Raf Meesen, Sybren Van Hoornweder","doi":"10.1016/j.clinph.2024.12.009","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.009","url":null,"abstract":"Objective: Corticospinal excitability can be quantified using motor-evoked potentials (MEP) following transcranial magnetic stimulation (TMS). However, the inherent variability of MEPs poses significant challenges. We establish a framework using personal and experimental factors to select the optimal number of trials (nopt) required for reliable MEP estimates.Methods: 47 healthy younger underwent single-pulse TMS over the left primary motor cortex (M1). Per participant, 550 MEPs were collected at intensities ranging from 110 % to 150 % of the resting motor threshold (rMT), in 10 % increments. Per intensity, we calculated nopt. We analyzed which personal and experimental factors affected nopt.Results: nopt decreased with increasing TMS intensity, lower rMT baseline values, and exclusion of single-trial outliers. Sex had no significant effect.Conclusions: Our study indicates that even when TMS is used as an outcome measure, custom-tailoring its protocol to study-related circumstances is key, as TMS intensity, outliers, baseline rMT, and the desired precision level affect the number of TMS trials needed to obtain a reliable MEP. Thus, we underscore the absence of a universal rule-of-thumb rule, although our predictive equations and online tool provide future TMS experimenters with the means to estimate the required number of TMS trials based on individual characteristics and specific experimental conditions.Significance: Our predictive equations offer a tailored approach for selecting nopt, enhancing the reliability of TMS-derived corticospinal excitability measurements.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"123-131"},"PeriodicalIF":3.7,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871572","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Frequency functional connectivity alterations in Alzheimer's disease and frontotemporal dementia: An EEG analysis using machine learning.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-12 DOI: 10.1016/j.clinph.2024.12.008

Huang Zheng, Han Xiao, Yinan Zhang, Haozhe Jia, Xing Ma, Yiqun Gan

{"title":"Time-Frequency functional connectivity alterations in Alzheimer's disease and frontotemporal dementia: An EEG analysis using machine learning.","authors":"Huang Zheng, Han Xiao, Yinan Zhang, Haozhe Jia, Xing Ma, Yiqun Gan","doi":"10.1016/j.clinph.2024.12.008","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.008","url":null,"abstract":"Objective: Alzheimer's disease (AD) and frontotemporal dementia (FTD) are prevalent neurodegenerative diseases characterized by altered brain functional connectivity (FC), affecting over 100 million people worldwide. This study aims to identify distinct FC patterns as potential biomarkers for differential diagnosis.Methods: Resting-state EEG data from 36 AD patients, 23 FTD patients, and 29 healthy controls were analyzed using time-frequency and bandpass filtering FC metrics. These metrics were estimated through Pearson's correlations, mutual information, and phase lag index, and served as input features in a support vector machine (SVM) with Leave-One-Out Cross-Validation for group classification.Results: Both AD and FTD exhibited significantly decreased FC in the theta band within the frontal lobe and increased FC in the beta band in the posterior regions. Additionally, a decreased FC in central regions at theta band was observed uniquely in AD, but not in FTD. SVM classification accuracies reached 95% for AD and 86% for FTD.Conclusions: High classification accuracies underscore the potential of these FC alterations as reliable biomarkers for AD and FTD.Significance: This is the first study to integrate time-frequency and bandpass filtering FC metrics to reveal brain network alterations in AD and FTD, providing new insights for diagnostics and neurodegenerative pathologies.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"110-119"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-density theta oscillatory-modulated tDCS over the parietal cortex for targeted memory enhancement. 通过顶叶皮层的高密度θ振荡调制tDCS，有针对性地增强记忆。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-12 DOI: 10.1016/j.clinph.2024.12.004

Milica Manojlović, Jovana Bjekić, Danka Purić, Saša R Filipović

{"title":"High-density theta oscillatory-modulated tDCS over the parietal cortex for targeted memory enhancement.","authors":"Milica Manojlović, Jovana Bjekić, Danka Purić, Saša R Filipović","doi":"10.1016/j.clinph.2024.12.004","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.12.004","url":null,"abstract":"Objectives: Associative memory (AM) declines due to healthy aging as well as in various neurological conditions. Standard transcranial electrical stimulation (tES) protocols show inconclusive facilitatory effects on AM, often lacking function specificity and stimulation focality. We tested the effectiveness of high-density electrode montage delivering anodal theta oscillatory-modulated transcranial direct current stimulation (HD-Theta-otDCS) over the left posterior parietal cortex (PPC), aiming to target AM in a spatially focused and function-specific manner.Methods: In a sham-controlled cross-over experiment we explored the differential effects of HD-Theta-otDCS applied during either encoding or the retrieval phases of two AM tasks (Face-Word and Object-Location). The stimulation protocol consisted of an anode over the left PPC (P3) and four surrounding return electrodes (CP1, CP5, PO3, POz) with electrical current oscillating in theta rhythm (5 Hz, 1.5 ± 0.5 mA).Results: HD-Theta-otDCS stimulation applied during both encoding and retrieval increased AM performance compared to sham control in the Face-Word task. We found no differences between the two active stimulation conditions.Conclusions: HD-Theta-otDCS showed to be a promising tool for enhancing AM, regardless of the stimulation timing. The results provide further support for our previous findings with bipolar otDCS and confirm that PPC stimulation can induce behaviorally relevant modulation in the memory-related cortico-subcortical networks.Significance: The presented approach is one step forward towards precision brain stimulation for memory neuromodulation. The novelty lies in the combination of increased focality and function-specific current waveform. Positive results set the ground for further research on HD-theta-otDCS effectiveness in clinical populations.","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"80-90"},"PeriodicalIF":3.7,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0