Clinical Neurophysiology最新文献

{"title":"Maximal motor unit firing rates decline with amyotrophic lateral sclerosis progression","authors":"Gabriel L. Fernandes ,&nbsp;Lucas B.R. Orssatto ,&nbsp;Matheus D. Pinto ,&nbsp;Joao S. Henkin ,&nbsp;Ehsan Shandiz ,&nbsp;Pamela A. McCombe ,&nbsp;Robert D. Henderson ,&nbsp;Gabriel S. Trajano","doi":"10.1016/j.clinph.2026.2111697","DOIUrl":"10.1016/j.clinph.2026.2111697","url":null,"abstract":"<div><h3>Objective</h3><div>Amyotrophic lateral sclerosis (ALS) is characterised by progressive degeneration of upper and lower motor neurons and their motor units (MUs). MU loss is compensated by collateral sprouting and reinnervation of muscle fibres. There is limited information about the properties of these surviving MUs as these processes take place. High-density surface electromyography (HD-sEMG) decomposition enables non-invasive analysis of individual MU firing behaviour during maximal voluntary contractions and assess their changes with ALS progression.</div></div><div><h3>Methods</h3><div>Thirty-nine individuals with ALS (24 men; mean age 63 ± 16 years) completed up to five visits (interval 20.0 ± 7.9 weeks). Tibialis anterior HD-sEMG recordings during maximal contractions were decomposed into individual MU spike trains, from which maximal firing rates were quantified. Muscle strength was assessed with the Medical Research Council (MRC) scale, and global function with the revised ALS Functional Rating Scale (ALSFRS-R).</div></div><div><h3>Results</h3><div>Maximal MU firing rates declined significantly over time [–0.32 Hz/month, (95% CI –0.44; –0.19)], regardless of MRC scores. Across participants, maximal firing rates decreased by 2.38 Hz (1.78; 2.98) for each 1-point reduction in MRC and by 0.54 Hz for each ALSFRS-R point (–0.83; –0.26).</div></div><div><h3>Conclusion</h3><div>These findings demonstrate that maximal MU firing rates decline as ALS progresses, suggesting that the surviving motor unit undergo progressive pathophysiological changes as motor neurons degenerate. HD-sEMG MU firing-rates analysis appeared more sensitive than MRC in detecting early deterioration in muscle decline.</div></div><div><h3>Significance</h3><div>Maximal firing rates analysis has the potential to serve as a quantitative clinical biomarker of neuromotor system degeneration, complementing global functional scales in clinical monitoring.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111697"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the surface: A prospective case-control study of electromyography in cervical dystonia","authors":"S.A.J.E.A. Lagerweij ,&nbsp;M. Smit ,&nbsp;L.M. Centen ,&nbsp;J.M.C. van Dijk ,&nbsp;D.L.M. Oterdoom ,&nbsp;M.E. van Egmond ,&nbsp;J.W. Elting ,&nbsp;M.A.J. Tijssen","doi":"10.1016/j.clinph.2026.2111708","DOIUrl":"10.1016/j.clinph.2026.2111708","url":null,"abstract":"<div><h3>Objective</h3><div>To identify potential EMG monitoring biomarkers for CD by comparing cervical muscle activity in patients and controls.</div></div><div><h3>Methods</h3><div>Fifteen CD patients and fifteen controls underwent bilateral EMG recordings from the sternocleidomastoid (SCM) and splenius capitis (SPL) muscles during rest and motor tasks. Power spectral density (PSD) in the 4–12 Hz range, co-contraction, overflow and intermuscular coherence were analyzed. Group differences were assessed with Mann-Whitney U tests and associations between EMG features and clinical severity scores were evaluated using Spearman correlations.</div></div><div><h3>Results</h3><div>CD patients showed significantly increased 4–12 Hz PSD across all neck muscles and tasks. Co-contraction and overflow were consistently observed and quantifiable. Intermuscular coherence was notably elevated in SCM pairs during active tasks. Preliminary correlations were found between PSD measures and clinical scores.</div></div><div><h3>Conclusions</h3><div>The study confirms four distinct EMG characteristics in CD: elevated 4–12 Hz PSD, co-contraction, overflow and intermuscular coherence, supporting their potential as objective monitoring biomarkers.</div></div><div><h3>Significance</h3><div>These findings provide electrophysiological validation of key EMG features in CD and highlight their potential for integration into research and clinical assessment, pending further methodological standardization.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111708"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147324933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-branch convolutional neural network and intracranial EEG high-frequency oscillations predict post-surgical seizure outcomes","authors":"Madhumathi Devaraj ,&nbsp;Yihe Chen ,&nbsp;Shuang Wang ,&nbsp;Michael R. Sperling ,&nbsp;Noa Herz ,&nbsp;Chenyuan Wu ,&nbsp;Richard Staba ,&nbsp;Jerome Engel Jr ,&nbsp;Itzhak Fried ,&nbsp;Charles Mikell ,&nbsp;Sima Mofakham ,&nbsp;Petar M. Djuric ,&nbsp;Shennan Aibel Weiss","doi":"10.1016/j.clinph.2026.2111702","DOIUrl":"10.1016/j.clinph.2026.2111702","url":null,"abstract":"<div><h3>Objective</h3><div>Pathological High-Frequency Oscillations (HFOs) identify epileptogenic cortex, but their surgical utility is unproven. Current epilepsy surgery planning relies on a “gold standard” multidisciplinary consensus. We tested if a Convolutional Neural Network (CNN), leveraging HFO features, neuroanatomy, and surgical boundaries, could predict seizure freedom.</div></div><div><h3>Methods</h3><div>HFOs were detected during NREM sleep EEG in 78 pre-surgical patients. A three-branch CNN was trained using SEEG contact inputs: stereotaxic coordinates, resection status, and 37 HFO features, utilizing known post-operative seizure outcome. Branches encoded spatial, electrophysiological, and surgical data. Outputs were concatenated and processed by fully connected layers; a final sigmoid layer predicted post-operative seizure freedom probability. Univariate HFO feature analysis employed two-way mixed-effect ANOVAs.</div></div><div><h3>Results</h3><div>The HFO-informed CNN model distinguished seizure-free patients with 92% accuracy using fivefold cross-validation. Univariate analysis suggested that fast ripples, especially those superimposed on epileptiform spikes, are important HFO features for the model.</div></div><div><h3>Conclusions</h3><div>A trained CNN model integrating HFO features, neuroanatomy, and surgical boundaries can accurately predict seizure freedom following “gold standard” surgical planning.</div></div><div><h3>Significance</h3><div>This CNN model, using inter-ictal non-REM sleep recordings, can predict surgical success and allow counterfactual virtual resections to be iteratively tested by the CNN ML to potentially improve post-operative seizure outcome.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111702"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147303160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevated gamma spectral event peak power during auditory chirp is associated with neuropsychiatric features in Fragile X syndrome","authors":"Yanchen Liu ,&nbsp;Peyton Siekierski ,&nbsp;Lisa A. De Stefano ,&nbsp;Grace Westerkamp ,&nbsp;Lauren Ethridge ,&nbsp;Elizabeth Blank ,&nbsp;Makoto Miyakoshi ,&nbsp;Ryan V. Thorpe ,&nbsp;Stephanie R. Jones ,&nbsp;Craig Erickson ,&nbsp;Paul S. Horn ,&nbsp;Ernest V. Pedapati","doi":"10.1016/j.clinph.2026.2111713","DOIUrl":"10.1016/j.clinph.2026.2111713","url":null,"abstract":"<div><h3>Objective</h3><div>Investigate transient, non-averaged electroencephalography (EEG) signals in the gamma frequency band during an auditory chirp paradigm in individuals with Fragile X syndrome (FXS), a population characterized by elevated background gamma power, and to assess their relationship with clinical features.</div></div><div><h3>Methods</h3><div>Source-localized EEG responses to auditory chirp stimulus were studied in 36 individuals with FXS and 39 typically developing controls (TDC). Transient high-power gamma-band events were extracted using a thresholding approach. Gamma event properties were compared between groups and correlated with mean EEG features and clinical measures.</div></div><div><h3>Results</h3><div>In male FXS subjects, gamma event peak power was increased in the temporal source and lacked correlation with inter-trial coherence (ITC). Event rate, duration, and frequency span were similar between groups. Event peak power was positively correlated with obsessive and stereotyped behavior scales.</div></div><div><h3>Conclusions</h3><div>Peak power of transient gamma events during auditory response is tonically elevated, dissociated from phase synchronization, and associated with neuropsychiatric features in FXS.</div></div><div><h3>Significance</h3><div>Identifying a tonic elevation of gamma event peak power in FXS during auditory processing suggests altered neural circuit mechanisms underlying aberrant gamma activity. This provides a more direct basis for understanding auditory hypersensitivity, fostering opportunities for back translation and targeted treatment development.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111713"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147321399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of low-intensity transcranial focused ultrasound targeting the motor thalamus for motor impairment after basal ganglia stroke","authors":"Zhongfei Bai ,&nbsp;Dan Yu ,&nbsp;Jack Jiaqi Zhang ,&nbsp;Feifei Zhu ,&nbsp;Shan Liang ,&nbsp;Minxia Jin ,&nbsp;Ke Zeng ,&nbsp;Jiani Lu ,&nbsp;Wenting Qin ,&nbsp;Ulf Ziemann ,&nbsp;Lingjing Jin","doi":"10.1016/j.clinph.2026.2111707","DOIUrl":"10.1016/j.clinph.2026.2111707","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111707"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147364446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced alpha-band phase coherence and cortical complexity in fibromyalgia: A tms-eeg exploratory study","authors":"Anne Jakobsen ,&nbsp;Enrico De Martino ,&nbsp;Bruno A.N. Couto ,&nbsp;Margit M. Bach ,&nbsp;Stian Ingemann-Molden ,&nbsp;Thorvaldur S. Palsson ,&nbsp;Jakob Udby Blicher ,&nbsp;Adenauer G. Casali ,&nbsp;Thomas Graven-Nielsen ,&nbsp;Daniel Ciampi de Andrade","doi":"10.1016/j.clinph.2026.2111711","DOIUrl":"10.1016/j.clinph.2026.2111711","url":null,"abstract":"<div><h3>Objectives</h3><div>Cortico-spinal excitability of the primary motor cortex (M1) is reduced in fibromyalgia, and repetitive transcranial magnetic stimulation (TMS) targeting M1 normalizes these changes and relieves symptoms. TMS combined with electroencephalography (TMS-EEG) allows the measurement of M1 excitability and its connectivity to other regions, which may help clarify neurophysiological abnormalities in fibromyalgia. We assessed cortical excitability, oscillatory activity, and complexity in individuals with fibromyalgia compared to pain-free healthy controls.</div></div><div><h3>Methods</h3><div>Global- and local-mean field power, peak-to-peak amplitude, event-related spectral perturbation, intertrial coherence (ITC), natural frequency, and perturbational complexity index (PCIst) of the EEG response after left-M1 TMS were compared between groups (n = 18 fibromyalgia; n = 15 controls). Pain intensity, interference, current therapy, mood, and quality of life were assessed in individuals with fibromyalgia.</div></div><div><h3>Results</h3><div>Compared with controls, individuals with fibromyalgia showed a reduction in the alpha-band ITC in middle- (p = 0.044) and right-parieto-occipital areas (p = 0.040). Middle-parieto-occipital ITC negatively correlated with reported pain relief (rho = -0.552, p = 0.019). The PCIst was lower in fibromyalgia compared with controls (p = 0.009) and correlated with higher pain interference in general activity (rho = -0.486, p = 0.042).</div></div><div><h3>Conclusion</h3><div>Individuals with fibromyalgia have abnormal cortical connectivity compared with asymptomatic controls.</div></div><div><h3>Significance</h3><div>TMS-EEG may provide insights on brain connectivity relevant for prognostication and therapy in fibromyalgia.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"185 ","pages":"Article 2111711"},"PeriodicalIF":3.6,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lacosamide modulates alpha-band network hubness: a quantitative EEG study in drug-Naïve focal epilepsy","authors":"Marco Sferruzzi ,&nbsp;Lorenzo Ricci ,&nbsp;Margherita A.G. Matarrese ,&nbsp;Mario Tombini ,&nbsp;Patrizia Pulitano ,&nbsp;Francesca Izzi ,&nbsp;Fabio Placidi ,&nbsp;Biagio Sancetta ,&nbsp;Vincenzo Di Lazzaro ,&nbsp;Giovanni Assenza","doi":"10.1016/j.clinph.2026.2111506","DOIUrl":"10.1016/j.clinph.2026.2111506","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates pharmaco-EEG changes induced by Lacosamide (LCM) in drug-naive people with focal epilepsy (PwE) and explores the association between quantitative EEG (qEEG) and long-term clinical outcome.</div></div><div><h3>Methods</h3><div>We retrospectively identified 28 PwE and 25 healthy controls (HC). PwE were classified as seizure-free (SF) or non-seizure-free (NSF) after two years of LCM. EEGs were acquired before and ∼ 6 months after LCM. Power spectral density (PSD), amplitude-envelope correlation (AEC), and graph-theoretical metrics were compared between PwE and HC. Logistic regression was employed to examine the association between long-term outcomes (two-year seizure freedom) and qEEG metrics, in combination with clinical variables (sex, aetiology, seizure type, baseline EEG).</div></div><div><h3>Results</h3><div>LCM did not significantly modify global-averaged qEEG metrics (p &gt; 0.05). Theta-band PSD was higher in PwE than HC. PwE exhibited higher alpha-band betweenness centrality (BtwC) than HC only before LCM (p = 0.007). Alpha-band BtwC provided the greatest discriminative value for seizure freedom (accuracy = 0.86; area under the curve [AUC] = 0.88).</div></div><div><h3>Conclusions</h3><div>Although no significant differences were observed between pre- and post-LCM conditions, alpha-band BtwC showed a return toward a more physiological state after treatment, suggesting partial network normalization. Combining qEEG with clinical data improved long-term outcome discrimination, with alpha-band BtwC as the most relevant feature.</div></div><div><h3>Significance</h3><div>Graph-theoretical qEEG metrics offer additional insight into LCM’s neurophysiological effects in focal epilepsy.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111506"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001739","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Error processing in major depressive disorder: a systematic review and meta-analysis of event-related potential studies","authors":"Kai-Jie Liang ,&nbsp;Chun-Che Hung ,&nbsp;Chia-Wen Ko ,&nbsp;Pin-Chi Lin ,&nbsp;Pei-Ying S Chan ,&nbsp;Chia-Hsiung Cheng","doi":"10.1016/j.clinph.2026.2111503","DOIUrl":"10.1016/j.clinph.2026.2111503","url":null,"abstract":"<div><h3>Objective</h3><div>Alterations in error-related negativity (ERN) and error positivity (Pe)—electrophysiological markers of error processing—have been frequently reported in major depressive disorder (MDD); findings, however, remain inconsistent.</div></div><div><h3>Methods</h3><div>Literature search was performed using Web of Science, MEDLINE/PubMed, and Scopus electronic databases. The effect sizes (Hedges’ g) in the comparisons of ERN (22 studies) and Pe (10 studies) amplitudes between MDD and healthy controls (HC) were employed by a random-effect, inverse-variance weighted model.</div></div><div><h3>Results</h3><div>ERN and Pe amplitudes in MDD patients were generally comparable to those of HC. Nevertheless, moderator analyses revealed specific conditions under which Pe amplitudes were reduced in MDD. Specifically, MDD patients with comorbid conditions showed diminished Pe amplitudes relative to HC (p = 0.001). Moreover, task type moderated Pe responses: studies using the Flanker task reported significantly reduced Pe amplitudes in MDD patients (p = 0.012), a pattern not observed with other paradigms. No significant moderators were identified for ERN amplitudes.</div></div><div><h3>Conclusions</h3><div>Comorbidity and task design, particularly the use of the Flanker task, appear to influence Pe amplitudes in patients with MDD and should be carefully considered in future research.</div></div><div><h3>Significance</h3><div>Our data highlight the importance of methodological factors in interpreting error processing deficits in MDD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111503"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146001740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of ictal OP-MEG","authors":"Stephanie Mellor ,&nbsp;George C. O’Neill ,&nbsp;Daniel Bush ,&nbsp;Arjun Ramaswamy ,&nbsp;Ryan C. Timms ,&nbsp;David Doig ,&nbsp;Tim M. Tierney ,&nbsp;Meaghan E. Spedden ,&nbsp;Matthew C. Walker ,&nbsp;Gareth R. Barnes ,&nbsp;Umesh Vivekananda","doi":"10.1016/j.clinph.2026.2111504","DOIUrl":"10.1016/j.clinph.2026.2111504","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111504"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relevance of EEG recording time for juvenile myoclonic epilepsy diagnosis confirmation: a reappraisal","authors":"Guillaume Thévoz ,&nbsp;Davide Bassi ,&nbsp;Andrea O. Rossetti","doi":"10.1016/j.clinph.2026.2111519","DOIUrl":"10.1016/j.clinph.2026.2111519","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"184 ","pages":"Article 2111519"},"PeriodicalIF":3.6,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}