Clinical Neurophysiology最新文献_第2页

Ultrasonographic characteristics of peripheral neuropathy in systemic lupus erythematosus 系统性红斑狼疮周围神经病变的超声特征。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.002

Nan Hu , Yuxue Nie , Xingbei Dong , Jingwen Niu , Liying Cui , Mingsheng Liu

{"title":"Ultrasonographic characteristics of peripheral neuropathy in systemic lupus erythematosus","authors":"Nan Hu , Yuxue Nie , Xingbei Dong , Jingwen Niu , Liying Cui , Mingsheng Liu","doi":"10.1016/j.clinph.2024.12.002","DOIUrl":"10.1016/j.clinph.2024.12.002","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the ultrasonographic characteristics of SLE-related peripheral neuropathy (PN) using nerve ultrasound.</div></div><div><h3>Methods</h3><div>Patients with SLE were recruited consecutively between December 2022 and June 2023. Detailed clinical assessment and nerve ultrasound were conducted on each SLE patient and healthy control (HC) at predetermined sites of peripheral nerves. The upper limit of the CSA for each nerve location was defined as 95th percentile in healthy controls for the identification of nerve enlargement. Nerve conduction studies (NCS) and relevant ancillary examinations were conducted on all SLE patients for comparisons.</div></div><div><h3>Results</h3><div>A total of 32 SLE female patients and age- and gender-marched 52 HC were finally recruited. At M6 (P = 0.041) point of median nerve, U1 (P < 0.001) and U6-10 (P < 0.001, =0.008, <0.001, <0.001, <0.001, respectively) points of ulnar nerve, the CSA in SLE patients were remarkably higher than that in HC. Mild and moderate nerve enlargement were detected in 12 and 20 SLE patients, respectively. Only 12 tested nerves showed both axonal damage in electrophysiological studies and nerve enlargement under ultrasound.</div></div><div><h3>Conclusion</h3><div>Nerve enlargement was extremely common in SLE patients, mainly in the forms of mild to moderate and focal thickening in upper limbs. There was significant inconsistency between NCS and ultrasound in detecting peripheral nerve involvement and a combined examination using NCS and nerve ultrasound might be more effective in detecting SLE-related PN.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 41-48"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-density theta oscillatory-modulated tDCS over the parietal cortex for targeted memory enhancement 通过顶叶皮层的高密度θ振荡调制tDCS，有针对性地增强记忆。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.004

Milica Manojlović , Jovana Bjekić , Danka Purić , Saša R. Filipović

{"title":"High-density theta oscillatory-modulated tDCS over the parietal cortex for targeted memory enhancement","authors":"Milica Manojlović , Jovana Bjekić , Danka Purić , Saša R. Filipović","doi":"10.1016/j.clinph.2024.12.004","DOIUrl":"10.1016/j.clinph.2024.12.004","url":null,"abstract":"<div><h3>Objectives</h3><div>Associative memory (AM) declines due to healthy aging as well as in various neurological conditions. Standard transcranial electrical stimulation (tES) protocols show inconclusive facilitatory effects on AM, often lacking function specificity and stimulation focality. We tested the effectiveness of high-density electrode montage delivering anodal theta oscillatory-modulated transcranial direct current stimulation (HD-Theta-otDCS) over the left posterior parietal cortex (PPC), aiming to target AM in a spatially focused and function-specific manner.</div></div><div><h3>Methods</h3><div>In a sham-controlled cross-over experiment we explored the differential effects of HD-Theta-otDCS applied during either encoding or the retrieval phases of two AM tasks (Face-Word and Object-Location). The stimulation protocol consisted of an anode over the left PPC (P3) and four surrounding return electrodes (CP1, CP5, PO3, POz) with electrical current oscillating in theta rhythm (5 Hz, 1.5 ± 0.5 mA).</div></div><div><h3>Results</h3><div>HD-Theta-otDCS stimulation applied during both encoding and retrieval increased AM performance compared to sham control in the Face-Word task. We found no differences between the two active stimulation conditions.</div></div><div><h3>Conclusions</h3><div>HD-Theta-otDCS showed to be a promising tool for enhancing AM, regardless of the stimulation timing. The results provide further support for our previous findings with bipolar otDCS and confirm that PPC stimulation can induce behaviorally relevant modulation in the memory-related cortico-subcortical networks.</div></div><div><h3>Significance</h3><div>The presented approach is one step forward towards precision brain stimulation for memory neuromodulation. The novelty lies in the combination of increased focality and function-specific current waveform. Positive results set the ground for further research on HD-theta-otDCS effectiveness in clinical populations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 80-90"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142863368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Time-Frequency functional connectivity alterations in Alzheimer’s disease and frontotemporal dementia: An EEG analysis using machine learning 阿尔茨海默病和额颞叶痴呆的时频功能连接改变：使用机器学习的脑电图分析。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.008

Huang Zheng , Han Xiao , Yinan Zhang, Haozhe Jia, Xing Ma, Yiqun Gan

{"title":"Time-Frequency functional connectivity alterations in Alzheimer’s disease and frontotemporal dementia: An EEG analysis using machine learning","authors":"Huang Zheng , Han Xiao , Yinan Zhang, Haozhe Jia, Xing Ma, Yiqun Gan","doi":"10.1016/j.clinph.2024.12.008","DOIUrl":"10.1016/j.clinph.2024.12.008","url":null,"abstract":"<div><h3>Objective</h3><div>Alzheimer’s disease (AD) and frontotemporal dementia (FTD) are prevalent neurodegenerative diseases characterized by altered brain functional connectivity (FC), affecting over 100 million people worldwide. This study aims to identify distinct FC patterns as potential biomarkers for differential diagnosis.</div></div><div><h3>Methods</h3><div>Resting-state EEG data from 36 AD patients, 23 FTD patients, and 29 healthy controls were analyzed using time-frequency and bandpass filtering FC metrics. These metrics were estimated through Pearson’s correlations, mutual information, and phase lag index, and served as input features in a support vector machine (SVM) with Leave-One-Out Cross-Validation for group classification.</div></div><div><h3>Results</h3><div>Both AD and FTD exhibited significantly decreased FC in the theta band within the frontal lobe and increased FC in the beta band in the posterior regions. Additionally, a decreased FC in central regions at theta band was observed uniquely in AD, but not in FTD. SVM classification accuracies reached 95% for AD and 86% for FTD.</div></div><div><h3>Conclusions</h3><div>High classification accuracies underscore the potential of these FC alterations as reliable biomarkers for AD and FTD.</div></div><div><h3>Significance</h3><div>This is the first study to integrate time-frequency and bandpass filtering FC metrics to reveal brain network alterations in AD and FTD, providing new insights for diagnostics and neurodegenerative pathologies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 110-119"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral nerve excitability abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with histopathological analysis 神经元核内包涵病的周围神经兴奋性异常：组织病理学分析评估。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.013

Yusuke Osaki , Hiroyuki Nodera , Ryota Sato , Shotaro Haji , Koji Fujita , Ryosuke Miyamoto , Kohei Muto , Hiroki Yamazaki , Hiroyuki Morino , Takashi Kanda , Shigeo Murayama , Ryuji Kaji , Yuishin Izumi

{"title":"Peripheral nerve excitability abnormalities in Neuronal Intranuclear Inclusion Disease: Assessment with histopathological analysis","authors":"Yusuke Osaki , Hiroyuki Nodera , Ryota Sato , Shotaro Haji , Koji Fujita , Ryosuke Miyamoto , Kohei Muto , Hiroki Yamazaki , Hiroyuki Morino , Takashi Kanda , Shigeo Murayama , Ryuji Kaji , Yuishin Izumi","doi":"10.1016/j.clinph.2024.12.013","DOIUrl":"10.1016/j.clinph.2024.12.013","url":null,"abstract":"<div><h3>Objective</h3><div>Neuronal Intranuclear Inclusion Disease (NIID) is a neurodegenerative disease affecting the central and peripheral nerves. We aimed to assess the pathophysiological features of peripheral nerve dysfunction in NIID.</div></div><div><h3>Methods</h3><div>We observed six unrelated NIID patients through clinical records, nerve conduction studies, and multiple measures of motor nerve excitability. Additionally, we reviewed one NIID patientt who underwent a nerve biopsy. Control measures were obtained from 22 age-matched normal subjects.</div></div><div><h3>Results</h3><div>The NIID patients exhibited mild conduction slowing and distinct nerve excitability abnormalities, including a significant decrease in excitability through hyperpolarizing threshold electrotonus (TE) and increased overshoots in both depolarizing and hyperpolarizing conditions. Histopathology revealed thinly myelinated fibers and axonal degeneration. Mathematical modeling suggested that reduced leak conductance was the key factor contributing to the observed excitability changes.</div></div><div><h3>Conclusions</h3><div>The findings indicate that NIID involves a complex interplay of axonal degeneration and myelin dysfunction, leading to unique peripheral nerve excitability changes. These results provide new insights into the pathophysiology of NIID.</div></div><div><h3>Significance</h3><div>Nerve excitability testing offers insight into particular axonal excitability abnormalities especially combined with histopathologic studies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 156-167"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tracking local and distant cortico-cortical interactions in brain tumor patients: A proof of concept TMS-EEG study 追踪脑肿瘤患者局部和远端皮质-皮质相互作用：TMS-EEG研究的概念验证。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.005

Chiara Mazzi , Elena Bertacco , Nicolò Cardobi , Alessandro Boaro , Francesco Sala , Silvia Savazzi , Chiara Bagattini

引用次数: 0

Comment on “Tonic stretch reflex threshold as a measure of disordered motor control and spasticity – A critical review” by Levin et al. (2024) 对Levin等人（2024）的“张力拉伸反射阈值作为运动控制紊乱和痉挛的测量-一项重要的回顾”的评论。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.016

John W. Chow, Stuart A. Yablon, Dobrivoje S. Stokic

引用次数: 0

Reply to: Commentary: Tonic stretch reflex threshold as a measure of disordered motor control and spasticity – A critical review 回复：评论：张力拉伸反射阈值作为运动控制紊乱和痉挛的测量-一个重要的回顾。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.017

Mindy F. Levin, Daniele Piscitelli, Joy Khayat

引用次数: 0

Self-regulation of slow cortical potential and seizure suppression by scalp electroencephalography: Early prediction of therapeutic efficacy 头皮脑电图对皮层慢电位的自我调节和癫痫抑制：治疗效果的早期预测。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.11.018

Tomoyuki Fumuro , Masao Matsuhashi , Masako Kinoshita , Riki Matsumoto , Ryosuke Takahashi , Akio Ikeda

{"title":"Self-regulation of slow cortical potential and seizure suppression by scalp electroencephalography: Early prediction of therapeutic efficacy","authors":"Tomoyuki Fumuro , Masao Matsuhashi , Masako Kinoshita , Riki Matsumoto , Ryosuke Takahashi , Akio Ikeda","doi":"10.1016/j.clinph.2024.11.018","DOIUrl":"10.1016/j.clinph.2024.11.018","url":null,"abstract":"<div><h3>Objective</h3><div>Seizure suppression using the neurofeedback (NFB) method by self-regulation of scalp-recorded slow cortical potential (SCP) is effective for patients with refractory focal epilepsy. However, the prolonged training period required prevents it from wider implementation as the standard treatment in clinical practice. Therefore, we examined whether it would be appropriate to shorten the training period, in spite of the small number of patients.</div></div><div><h3>Methods</h3><div>12 patients participated the NFB training. 1 course of NFB training consisted of 35 sessions divided into 2 phases. After each phase we evaluated whether each patient acquired NFB control, and seizure reduction was assessed compared to that before training.</div></div><div><h3>Results</h3><div>Of 11 patients who completed the first training phase, 4 showed reduced post-training seizure frequency, of whom 3 could regulate the SCP polarity (NFB control). Of the remaining 7, 2 acquired NFB control during the second training phase but seizure frequency did not decrease. Furthermore, the other 5 did not acquire NFB control, and seizure frequency did not decrease.</div></div><div><h3>Conclusions</h3><div>Patients who acquired NFB control within a short period, i.e., 3 weeks, were more likely to exhibit a lower post-training seizure frequency.</div></div><div><h3>Significance</h3><div>SCP self-regulation can be acquired within a short period and is associated with seizure reduction.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 182-191"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reorganization of pragmatic language networks in patients with temporal lobe epilepsy 颞叶癫痫患者语用网络的重组。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.12.012

Bautista Elizalde Acevedo , Silvia Kochen , Lucy Alba-Ferrara , Mariana Bendersky

{"title":"Reorganization of pragmatic language networks in patients with temporal lobe epilepsy","authors":"Bautista Elizalde Acevedo , Silvia Kochen , Lucy Alba-Ferrara , Mariana Bendersky","doi":"10.1016/j.clinph.2024.12.012","DOIUrl":"10.1016/j.clinph.2024.12.012","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the neural networks involved in idiomatic expressions (IE) comprehension in healthy controls and patients with drug-resistant temporal lobe epilepsy (TLE), with a functional magnetic resonance imaging (fMRI) task.</div></div><div><h3>Methods</h3><div>Thirty-two patients with TLE (left or right) and seventeen healthy controls were evaluated. Activated nodes in the fMRI task were defined as Regions of Interest (ROIs) for a posterior functional connectivity analysis.</div></div><div><h3>Results</h3><div>All participants completed the task successfully. We found a bilateral fronto-temporal network, lateralized to the right, during IE processing in the overall sample. Compared to controls, patients additionally activated frontal, temporal, and insular areas in both hemispheres. Controls exhibited fewer connections but greater inhibitory connectivity, while the opposite (more connections and increased excitatory connectivity) occurred in patients. Compared to controls, TLE patients recruited additional brain areas on top of the expected bilateral frontotemporal network. The connectivity analysis revealed that controls exhibited more effective inhibitory connectivity, with more modular ROIs. In contrast, patients demonstrated greater excitatory connectivity.</div></div><div><h3>Conclusion</h3><div>The results suggest compensatory neural recruitment in additional areas in TLE during IE comprehension.</div></div><div><h3>Significance</h3><div>Exacerbated connections in TLE may reflect the need to recruit alternative regions, resulting in higher costs and lower efficiency of the neural network.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 194-205"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142913821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sleep spindle variation in patients with Parkinson’s disease on first nights of sub-optimal deep brain stimulation 帕金森病患者在次优深部脑刺激第一夜的睡眠纺锤体变化

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-01 DOI: 10.1016/j.clinph.2024.11.020

Rig Das , Stephen V. Gliske , Dulce Maroni , Miguel Situ-Kcomt , Leslie C West , Michael O Summers , Siqun Tang , Pavan A. Vaswani , Casey H. Halpern , John A. Thompson , Clete A. Kushida , Aviva Abosch

{"title":"Sleep spindle variation in patients with Parkinson’s disease on first nights of sub-optimal deep brain stimulation","authors":"Rig Das , Stephen V. Gliske , Dulce Maroni , Miguel Situ-Kcomt , Leslie C West , Michael O Summers , Siqun Tang , Pavan A. Vaswani , Casey H. Halpern , John A. Thompson , Clete A. Kushida , Aviva Abosch","doi":"10.1016/j.clinph.2024.11.020","DOIUrl":"10.1016/j.clinph.2024.11.020","url":null,"abstract":"<div><h3>Objective</h3><div>Deep brain stimulation (DBS) targeting the subthalamic nucleus (STN) is a common treatment for motor symptoms of Parkinson’s disease but its influence on non-motor symptoms is less clear. Sleep spindles are known to be reduced in patients with Parkinson’s disease, but the effect of STN DBS is unknown. The objective of our study was to address this knowledge gap.</div></div><div><h3>Method</h3><div>Polysomnograms were recorded for three consecutive nights in 15 patients with advanced Parkinson’s disease (11 male, 4 female; age: 53–75 years), including at least one night each of unilateral STN DBS stimulation ON and OFF. Stimulation ON was set to 70 % of clinical amplitude to mitigate sleep being altered via changing motor symptoms or due to patient awareness of stimulation. Sleep spindles were detected in electroencephalogram (EEG) data by two previously published, validated automated sleep spindle detection algorithms: Ferrarelli et al. (2007) and Martin et al. (2013).</div></div><div><h3>Results</h3><div>Sleep spindle density was higher during stimulation ON than OFF nights in 11 of 12 subjects using either sleep spindle detection algorithm (p<=0.01, Wilcoxon rank sum). Stimulation ON versus OFF had no statistically significant effect on sleep spindle duration or amplitude.</div></div><div><h3>Conclusion</h3><div>Our analysis indicates that a single night of sub-optimal STN stimulation significantly increases sleep spindle density in Parkinson’s disease patients.</div></div><div><h3>Significance</h3><div>These results further our understanding of how DBS impacts non-motor symptoms of Parkinson’s disease.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"Pages 91-97"},"PeriodicalIF":3.7,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0