Clinical Neurophysiology最新文献_第2页

Pretreatment TMS-EEG connectivity assessment as a potential predictor of rTMS effectiveness in chronic pain: A feasibility pilot study.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-03-10 DOI: 10.1016/j.clinph.2025.02.268

Enrico De Martino, Bruno Andry Nascimento Couto, Anne Jakobsen, Adenauer Girardi Casali, Poul Dane Bonde-Heriksen, Thomas Graven-Nielsen, Daniel Ciampi de Andrade

{"title":"Pretreatment TMS-EEG connectivity assessment as a potential predictor of rTMS effectiveness in chronic pain: A feasibility pilot study.","authors":"Enrico De Martino, Bruno Andry Nascimento Couto, Anne Jakobsen, Adenauer Girardi Casali, Poul Dane Bonde-Heriksen, Thomas Graven-Nielsen, Daniel Ciampi de Andrade","doi":"10.1016/j.clinph.2025.02.268","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.02.268","url":null,"abstract":"<p><strong>Objective: </strong>Around half of chronic pain patients report pain intensity reduction to high-frequency (10 Hz) repetitive transcranial magnetic stimulation (rTMS) delivered to the primary motor cortex (M1). However, the other half do not respond, making it essential to identify which patients are likely to benefit before starting treatment. Combining TMS with electroencephalogram (TMS-EEG) allows for exploring cortical connectivity, and evaluating this connectivity before administering rTMS may provide insights into which patients are likely to respond favorably to the treatment.</p><p><strong>Methods: </strong>Seven chronic pain patients underwent TMS-EEG assessment of M1 before ten daily sessions of 10 Hz rTMS. Pain intensity was measured at baseline and post-treatment, with responders defined as those showing a 30 % reduction on an 11-point numerical rating scale. TMS-evoked potentials were analyzed using the debiased weighted phase lag index to assess connectivity, quantified by phase (connections exceeding the 95 % confidence interval) and space (Euclidean distance between significantly connected EEG channels). Normative connectivity values were also collected from 82 healthy volunteers.</p><p><strong>Results: </strong>Four patients responded to M1 rTMS, while three did not, with an average pain intensity reduction of 1.4±1.5. TMS-EEG showed low connectivity indices in all responders to rTMS, whereas two non-responders had higher indices, above the 75th percentile of healthy volunteers.</p><p><strong>Conclusions: </strong>This pilot feasibility study showed that the use of TMS-EEG informed rTMS is feasible, and proceeding to larger randomized clinical trials will allow to test this approach.</p><p><strong>Significance: </strong>Pre-treatment TMS-EEG connectivity measures may identify rTMS responders, optimizing chronic pain management.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143623966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensorimotor integration and faces recognition in a model of altered face sensory information: Neurophysiological study in patients with dentofacial deformities

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-03-09 DOI: 10.1016/j.clinph.2025.02.269

Mohammed Zeroual , Francesca Ginatempo , Nicola Loi , Luigi Angelo Vaira , Antonella Cano , Andrea Biglio , Giulio Visaloco , Giacomo De Riu , Franca Deriu

{"title":"Sensorimotor integration and faces recognition in a model of altered face sensory information: Neurophysiological study in patients with dentofacial deformities","authors":"Mohammed Zeroual , Francesca Ginatempo , Nicola Loi , Luigi Angelo Vaira , Antonella Cano , Andrea Biglio , Giulio Visaloco , Giacomo De Riu , Franca Deriu","doi":"10.1016/j.clinph.2025.02.269","DOIUrl":"10.1016/j.clinph.2025.02.269","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the excitability and sensory motor integration of the face and masticatory primary motor cortex (M1), and recognition of face expressions in individuals with dentofacial deformities (IDD).</div></div><div><h3>Methods</h3><div>Short-interval intracortical inhibition (SICI), short-afferent inhibition (SAI) of masticatory and face M1, the blink reflex and face expressions recognition (FER) ability were assessed in 18 healthy subjects (HS) (24.56 ± 1.02 years old) and in 18 IDD (27.36 ± 1.39 years) before and after 1 month from surgery.</div></div><div><h3>Results</h3><div>In IDD, SICI (p = 0.033) and SAI (p = 0.008) were significantly reduced in the masticatory, but not face, M1 and the blink reflex was normal. IDD also exhibited deficits in FER before surgery (p = 0.033), which was still present after surgery (p = 0.015), although improved.</div></div><div><h3>Conclusion</h3><div>Results evidence that alterations of sensory afferents due to dentofacial deformities modulates sensorimotor integration of masticatory M1, with topographic specificity. The altered sensory information from face not only influences motor inhibitory control but also FER.</div></div><div><h3>Significance</h3><div>The integration of sensory inputs with motor outputs depends topographically on the type of sensory afferents stimulated as well as on the target muscle and its respective representation area in M1. Afferent information from face also plays a role in FER ability.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 113-123"},"PeriodicalIF":3.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143628589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exercise-induced changes in high-γ cortical functional connectivity and short-interval intracortical inhibition

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-03-09 DOI: 10.1016/j.clinph.2025.02.274

Matteo Conti , Federico Carparelli , Roberta Bovenzi , Valerio Ferrari , Battista Di Gioia , Nicola Biagio Mercuri , Alessandro Stefani , Maria Giuseppina Palmieri

{"title":"Exercise-induced changes in high-γ cortical functional connectivity and short-interval intracortical inhibition","authors":"Matteo Conti , Federico Carparelli , Roberta Bovenzi , Valerio Ferrari , Battista Di Gioia , Nicola Biagio Mercuri , Alessandro Stefani , Maria Giuseppina Palmieri","doi":"10.1016/j.clinph.2025.02.274","DOIUrl":"10.1016/j.clinph.2025.02.274","url":null,"abstract":"<div><h3>Objective</h3><div>To analyze exercise-induced changes in functional connectivity (FC) using high-density EEG (HD-EEG) and primary motor cortex excitability via paired-pulse TMS (pp-TMS).</div></div><div><h3>Methods</h3><div>Ten healthy volunteers performed a 3 km high-intensity run. Neurophysiological assessments were conducted at baseline (T0), 24 h (T1), and 72 h (T2) post-exercise. FC was measured using HD-EEG, and primary motor cortex excitability was assessed with pp-TMS to measure short-interval intracortical inhibition (SICI) and facilitation (ICF).</div></div><div><h3>Results</h3><div>At T1, a significant hyperconnected network in the high-γ band was observed in several brain regions, including sensorimotor, limbic, temporal, and occipital lobes, which normalized by T2. Additionally, pp-TMS revealed disinhibition (reduced SICI) in M1 at ISI 2–3 ms at T1.</div></div><div><h3>Conclusions</h3><div>The study highlighted specific features of exercise-induced central fatigue. Post-exercise, the primary motor cortex became hyperexcitable, possibly as a compensatory response to peripheral fatigue. A complex network of cortical areas involved in cognition and behavior was hyperactivated, likely reflecting awareness of fatigue and self-protection decision-making processes. These changes were reversible, allowing subjects to return to baseline conditions.</div></div><div><h3>Significance</h3><div>This research provides insight into the neurophysiological mechanisms of central fatigue, emphasizing the brain’s adaptive responses to intense physical activity and their temporal dynamics.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 24-30"},"PeriodicalIF":3.7,"publicationDate":"2025-03-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

EEG microstates during resting-state and dissociative events in patients with psychogenic non-epileptic seizures

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-03-08 DOI: 10.1016/j.clinph.2025.03.002

Cecilia Catania , Marco Mancuso , Adolfo Mazzeo , Enrico Michele Salamone , Biagio Orlando , Alessandra Morano , Giorgio Leodori , Sara Casciato , Giancarlo Di Gennaro , Anna Teresa Giallonardo , Carlo Di Bonaventura , Emanuele Cerulli Irelli

{"title":"EEG microstates during resting-state and dissociative events in patients with psychogenic non-epileptic seizures","authors":"Cecilia Catania , Marco Mancuso , Adolfo Mazzeo , Enrico Michele Salamone , Biagio Orlando , Alessandra Morano , Giorgio Leodori , Sara Casciato , Giancarlo Di Gennaro , Anna Teresa Giallonardo , Carlo Di Bonaventura , Emanuele Cerulli Irelli","doi":"10.1016/j.clinph.2025.03.002","DOIUrl":"10.1016/j.clinph.2025.03.002","url":null,"abstract":"<div><h3>Objective</h3><div>Previous neuroimaging studies indicate complex network alterations in psychogenic non-epileptic seizures (PNES) patients, but brain activity modifications occurring during PNES remain unexplored. This study aimed to analyze EEG microstate metrics in PNES patients both during events and resting state to investigate the neurophysiological changes underlying these dissociative events.</div></div><div><h3>Methods</h3><div>We recruited 22 PNES patients and 24 age- and sex-matched healthy controls. Inclusion criteria included a history of PNES and at least one recorded akinetic PNES during video-EEG.</div></div><div><h3>Results</h3><div>A two-way repeated-measures ANOVA revealed significant class*condition interactions for microstate duration (p = 0.017), coverage (p = 0.012), and global field power (GFP) (p = 0.008). Post-hoc FDR-adjusted paired t-tests showed a significant decrease in microstate C duration (p = 0.036), coverage (p = 0.04), and GFP (p = 0.036) during PNES events compared to resting state. Mann-Whitney U tests showed significantly higher microstate C duration in PNES patients during resting state compared to controls (p = 0.009).</div></div><div><h3>Conclusions</h3><div>Microstate C, previously associated with the default mode network, showed increased duration during resting state and decreased representation during PNES, suggesting a prominent shift in neural activity dynamics within this network during dissociative events.</div></div><div><h3>Significance</h3><div>  <!-->an interplay between pathological and adaptive mechanisms in their pathophysiology.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 124-131"},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143629312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-03-08 DOI: 10.1016/j.clinph.2025.03.003

Elana R. Goldenkoff , Joseph A. Deluisi , James A. Brissenden , Taraz G. Lee , Thad A. Polk , Stephan F. Taylor , Benjamin M. Hampstead , Michael Vesia

{"title":"Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults","authors":"Elana R. Goldenkoff , Joseph A. Deluisi , James A. Brissenden , Taraz G. Lee , Thad A. Polk , Stephan F. Taylor , Benjamin M. Hampstead , Michael Vesia","doi":"10.1016/j.clinph.2025.03.003","DOIUrl":"10.1016/j.clinph.2025.03.003","url":null,"abstract":"<div><h3>Introduction</h3><div>Cortical paired associative stimulation (cPAS), repeated at spaced intervals and applied to the primary motor cortex (M1) and posterior parietal cortex (PPC), has a dose-dependent effect on corticomotor excitability in young adults. The present study investigated whether aging affects this additive (nonhomeostatic) metaplasticity by performing the same manipulation in a sample of older adults.</div></div><div><h3>Methods</h3><div>In the multi-dose cPAS condition, three consecutive sessions of the Hebbian-plasticity-induction cPAS protocol were administered with a 50-minute interval between sessions. In the single-dose control cPAS condition, one session of the Hebbian-plasticity-induction cPAS protocol was followed by two sessions of a control non-Hebbian cPAS protocol. We measured motor-evoked potentials (MEPs) before and after each cPAS session.</div></div><div><h3>Results</h3><div>Compared to a single dose of cPAS, the multi-dose cPAS protocol prevented the reduction in MEP amplitude, resulting in relatively greater corticomotor excitability following the Hebbian procedures. We did not find evidence for an increase in MEP amplitude after the repeated, spaced Hebbian-plasticity-induction cPAS protocol from baseline levels, suggesting reduced neuroplasticity in older adults compared to young adults.</div></div><div><h3>Conclusion</h3><div>Repeated spaced paired-associative stimulation to the parietal-motor pathway maintains corticomotor excitability in older adults.</div></div><div><h3>Significance</h3><div>These findings provide insight into age-related differences in neuroplastic capacity in healthy humans.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 76-85"},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143619428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intraoperative evaluation using a multimodality probe of temperature-dependent neurovascular modulation during focal brain cooling

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-03-08 DOI: 10.1016/j.clinph.2025.02.262

Takao Inoue , Sadahiro Nomura , Toshitaka Yamakawa , Sayuki Takara , Hirochika Imoto , Yuichi Maruta , Masatsugu Niwayama , Michiyasu Suzuki

{"title":"Intraoperative evaluation using a multimodality probe of temperature-dependent neurovascular modulation during focal brain cooling","authors":"Takao Inoue , Sadahiro Nomura , Toshitaka Yamakawa , Sayuki Takara , Hirochika Imoto , Yuichi Maruta , Masatsugu Niwayama , Michiyasu Suzuki","doi":"10.1016/j.clinph.2025.02.262","DOIUrl":"10.1016/j.clinph.2025.02.262","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to assess the effects of focal brain cooling (FBC) on human brain tissue through use of multiple sensing techniques by monitoring cerebrovascular activity and brain temperature.</div></div><div><h3>Methods</h3><div>Intraoperative brain activity monitoring using a multimodality probe capable of measuring brain temperature, electrocorticography (ECoG) and changes in cerebral hemoglobin concentration was performed in 13 patients with refractory epilepsy. Brain temperature and neurovascular activity were measured beneath and surrounding the FBC device. Data were categorized into three temperature ranges [low-temperature range (LTR, <18 °C), moderate-temperature range (MTR, 18 °C–28 °C), and high-temperature range (HTR, >28 °C)] for analysis.</div></div><div><h3>Results</h3><div>Changes in oxyhemoglobin (ΔO<sub>2</sub>Hb) and deoxyhemoglobin (ΔHHb) across the temperature ranges showed a U-shape and inverted U-shape pattern, respectively. ΔO<sub>2</sub>Hb decreased and ΔHHb increased in the MTR, reflecting enhanced neuronal activity and increased oxygen consumption. Conversely, ΔO<sub>2</sub>Hb increased and ΔHHb decreased in the LTR, indicating suppressed neuronal activity and reduced oxygen consumption. These findings highlight the temperature-dependent modulation of neurovascular activity by FBC, driven by distinct non-linear patterns.</div></div><div><h3>Conclusions</h3><div>FBC selectively influenced brain electrical activity and hemoglobin concentration, highlighting its subtle effects on neurovascular dynamics.</div></div><div><h3>Significance</h3><div>These findings provide critical insights into optimizing cooling strategies for neurological disorders using multimodality probes and FBC devices.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"173 ","pages":"Pages 31-42"},"PeriodicalIF":3.7,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143594194","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Auditory cortical and brainstem response dynamics in quiet and noise amongst unilaterally deaf adults with and without tinnitus

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-28 DOI: 10.1016/j.clinph.2025.02.260

MinChul Park , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin

{"title":"Auditory cortical and brainstem response dynamics in quiet and noise amongst unilaterally deaf adults with and without tinnitus","authors":"MinChul Park , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin","doi":"10.1016/j.clinph.2025.02.260","DOIUrl":"10.1016/j.clinph.2025.02.260","url":null,"abstract":"<div><h3>Objective</h3><div>Cortical auditory evoked potentials (CAEPs) and Auditory Brainstem Responses (ABRs) elicited by sounds in quiet and in noise were compared between unilaterally deaf adults with and without associated tinnitus (UD+T and UD-T). CAEP amplitudes were hypothesised to primarily vary with absolute stimulus levels in UD+T listeners rather than signal-to-noise ratio (SNR), whereas ABR amplitudes would reflect both level and SNR regardless of tinnitus status.</div></div><div><h3>Methods</h3><div>Responses were recorded at 60 and 45 dB nHL with white noise set to give 0 and +10 dB SNR. Participants were 8 UD-T, 13 UD+T listeners, and 13 binaurally hearing controls.</div></div><div><h3>Results</h3><div>The UD-T group CAEP amplitudes showed an additive effect of stimulus level (p = 0.025) and SNR (p = 0.002) while UD+T and control listeners showed only the effect of SNR (p = 0.004). ABR amplitudes reflected the additive effects of level and SNR in all groups.</div></div><div><h3>Conclusions</h3><div>The primary determinant of CAEP amplitudes to signals in noise is SNR not stimulus level. This effect was not apparent in UD-T listeners, whose amplitudes were determined by both level and SNR, similarly to the brainstem potentials.</div></div><div><h3>Significance</h3><div>The findings suggest altered processing of neural noise in unilaterally deaf adult listeners without tinnitus.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"172 ","pages":"Pages 81-90"},"PeriodicalIF":3.7,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Plasticity of the auditory cortex and brainstem in surgically induced unilaterally deaf adult humans with and without tinnitus

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-27 DOI: 10.1016/j.clinph.2025.02.259

MinChul Park , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin

{"title":"Plasticity of the auditory cortex and brainstem in surgically induced unilaterally deaf adult humans with and without tinnitus","authors":"MinChul Park , Greg A. O’Beirne , Philip A. Bird , Michael R.D. Maslin","doi":"10.1016/j.clinph.2025.02.259","DOIUrl":"10.1016/j.clinph.2025.02.259","url":null,"abstract":"<div><h3>Objective</h3><div>Cortical auditory evoked potentials (CAEPs) and auditory brainstem responses (ABRs) were compared between surgically induced unilaterally deaf (UD) adult humans with tinnitus (UD+T), without tinnitus (UD-T), and with binaurally hearing controls (CO). We hypothesised increased CAEP amplitudes from UD+T individuals, and increased ABR amplitudes from all UD individuals.</div></div><div><h3>Methods</h3><div>Data were gathered from 34 individuals (8 UD-T, 13 UD+T, 13 CO) using a 64-channel BioSemi device. Stimuli were delivered monaurally at 60 dB nHL. Evoked potential amplitudes and scalp topographies were compared between groups.</div></div><div><h3>Results</h3><div>Only UD+T individuals showed higher N1 amplitude compared to the controls (1.48 versus 1.04 μV) over the ipsilateral hemisphere (relative to intact ear). Higher ABR wave III/V ratios were revealed in both UD groups (UD-T 0.426 and UD+T 0.317) compared with the CO group (0.213), regardless of channel.</div></div><div><h3>Conclusions</h3><div>Tinnitus is thought to be a perceptual correlate of deafferentation-induced activity increase within the central auditory system (CAS) and the present findings support this. However, increased CAEP amplitude was observed amongst UD+T individuals, while altered ABR amplitude was observed in all UD listeners, suggesting deafferentation alone is insufficient for tinnitus.</div></div><div><h3>Significance</h3><div>Deafferentation and associated increased brainstem activity may be necessary but insufficient for triggering tinnitus.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"172 ","pages":"Pages 70-80"},"PeriodicalIF":3.7,"publicationDate":"2025-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143547817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluation of spasticity

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-21 DOI: 10.1016/j.clinph.2025.02.258

Eva Rudjord Therkildsen , Jakob Lorentzen , Monica A. Perez , Jens Bo Nielsen

引用次数: 0

Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-02-13 DOI: 10.1016/j.clinph.2025.02.256

Claudio Babiloni , Xianghong Arakaki , Sandra Baez , Robert J. Barry , Alberto Benussi , Katarzyna Blinowska , Laura Bonanni , Barbara Borroni , Jorge Bosch Bayard , Giuseppe Bruno , Alessia Cacciotti , Filippo Carducci , John Carino , Matteo Carpi , Antonella Conte , Josephine Cruzat , Fabrizia D’Antonio , Stefania Della Penna , Claudio Del Percio , Pierfilippo De Sanctis , Anita Kamondi

{"title":"Alpha rhythm and Alzheimer’s disease: Has Hans Berger’s dream come true?","authors":"Claudio Babiloni , Xianghong Arakaki , Sandra Baez , Robert J. Barry , Alberto Benussi , Katarzyna Blinowska , Laura Bonanni , Barbara Borroni , Jorge Bosch Bayard , Giuseppe Bruno , Alessia Cacciotti , Filippo Carducci , John Carino , Matteo Carpi , Antonella Conte , Josephine Cruzat , Fabrizia D’Antonio , Stefania Della Penna , Claudio Del Percio , Pierfilippo De Sanctis , Anita Kamondi","doi":"10.1016/j.clinph.2025.02.256","DOIUrl":"10.1016/j.clinph.2025.02.256","url":null,"abstract":"<div><div>In this “centenary” paper, an expert panel revisited Hans Berger’s groundbreaking discovery of human restingstate electroencephalographic (rsEEG) alpha rhythms (8–12 Hz) in 1924, his foresight of substantial clinical applications in patients with “senile dementia,” and new developments in the field, focusing on Alzheimer’s disease (AD), the most prevalent cause of dementia in pathological aging.</div><div>Clinical guidelines issued in 2024 by the US National Institute on Aging-Alzheimer’s Association (NIA-AA) and the European Neuroscience Societies did not endorse routine use of rsEEG biomarkers in the clinical workup of older adults with cognitive impairment. Nevertheless, the expert panel highlighted decades of research from independent workgroups and different techniques showing consistent evidence that abnormalities in rsEEG delta, theta, and alpha rhythms (< 30 Hz) observed in AD patients correlate with wellestablished AD biomarkers of neuropathology, neurodegeneration, and cognitive decline. We posit that these abnormalities may reflect alterations in oscillatory synchronization within subcortical and cortical circuits, inducing cortical inhibitory-excitatory imbalance (in some cases leading to epileptiform activity) and vigilance dysfunctions (e.g., mental fatigue and drowsiness), which may impact AD patients’ quality of life.</div><div>Berger’s vision of using EEG to understand and manage dementia in pathological aging is still actual.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"172 ","pages":"Pages 33-50"},"PeriodicalIF":3.7,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143437030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0