Clinical Neurophysiology最新文献

{"title":"Electro-clinical changes during CASK-related encephalopathy evolution","authors":"Elena Freri , Davide Caputo , Andrea Stabile , Laura Canafoglia , Paola Costa , Federica Rachele Danti , Tiziana Granata , Barbara Castellotti , Luciana Musante , Caterina Zanus","doi":"10.1016/j.clinph.2025.2110778","DOIUrl":"10.1016/j.clinph.2025.2110778","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110778"},"PeriodicalIF":3.7,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144279295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Seeing things in psychosis: Reduced theta power in early neural responses to ambiguous visual stimuli predicts perceptual distortions","authors":"Kayla R. Donaldson ,&nbsp;Victor J. Pokorny ,&nbsp;Eric Rawls ,&nbsp;Cheryl A. Olman ,&nbsp;Scott R. Sponheim","doi":"10.1016/j.clinph.2025.2110782","DOIUrl":"10.1016/j.clinph.2025.2110782","url":null,"abstract":"<div><h3>Objective</h3><div>In this study we aimed to identify possible neural origins of perceptual disturbances in psychotic disorders.</div></div><div><h3>Methods</h3><div>Individuals with schizophrenia and bipolar disorder with psychosis (<em>n</em> = 40), their biological siblings (<em>n</em> = 17), and healthy controls (<em>n</em> = 27) viewed ambiguous object stimuli equivalent in primary visual cortical processing demands, allowing for identification of neural abnormalities occurring beyond basic sensory processing. Magnetoencephalography was collected and neural oscillations were quantified using time–frequency analysis.</div></div><div><h3>Results</h3><div>Individuals with schizophrenia showed reduced early theta responses over occipital cortex and diminished late desynchronization of alpha/beta in select conditions over parietal cortex. Reduced theta was associated with more schizotypal traits and self-reported perceptual anomalies. Less alpha/beta desynchronization was marginally associated with greater negative symptoms.</div></div><div><h3>Conclusions</h3><div>Visual cortical anomalies in schizophrenia beyond primary visual cortex are reflected in reduced early occipital theta oscillations. This impaired bottom-up sensory processing is related to everyday perceptual abnormalities. Diminished later alpha/beta desynchronization in schizophrenia may reflect difficulty disengaging from default mode to access top-down mechanisms that facilitate perception.</div></div><div><h3>Significance</h3><div>Early sensory signals, communicated through theta-band oscillations, and later semantic processing, engaged through the desynchronization of alpha/beta oscillations, contribute to ambiguous object detection as well as perceptual disturbances in schizophrenia.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110782"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cognitive effects of a single dose of methylphenidate in Parkinson’s disease patients using electrophysiological measures","authors":"Noa Fogelson ,&nbsp;Estela Martinez Lopez ,&nbsp;Mirian Roson Gonzalez ,&nbsp;Miguel Fernandez-del-Olmo ,&nbsp;Tanya Gurevich ,&nbsp;Lydia Vela Desojo","doi":"10.1016/j.clinph.2025.2110781","DOIUrl":"10.1016/j.clinph.2025.2110781","url":null,"abstract":"<div><h3>Objectives</h3><div>Recent studies have suggested that methylphenidate (MPD) may have therapeutic effects in Parkinson’s disease (PD) patients, primarily on gait and apathy. We examined the cognitive effects of a single 20 mg dose of MPD in non-demented PD patients, using behavioral and electrophysiological measures, in a randomized, double-blind, placebo-controlled, single-dose, cross-over clinical trial study.</div></div><div><h3>Methods</h3><div>To this end, we recorded electroencephalography (EEG) in twenty-two PD patients during the performance of an extended version of a visual oddball task, while patients were in ON state. We compared the processing of predictive versus random targets, and the extent to which predictive sequences are utilized. Two recording sessions (20 mg of MPD or placebo) were performed in each patient, 7–14 days apart, in a double-blinded, randomized, counterbalanced manner.</div></div><div><h3>Results</h3><div>We found that a single-dose of MPD induced shorter P3b latencies for task-relevant predicted targets in the MPD compared to the placebo session.</div></div><div><h3>Conclusions</h3><div>A single-dose of MPD induced an event-related facilitation of target detection of predicted stimuli, compared to placebo, in non-demented patients with PD.</div></div><div><h3>Significance</h3><div>Our findings suggest that MPD may have beneficial cognitive effects in normotensive patients with PD, by enhancing top-down endogenous control processes, which are altered in PD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110781"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The GREENBEAN checklist for reporting studies evaluating the effectiveness of EEG-based biomarkers","authors":"Joshua B. Ewen ,&nbsp;Claudio Babiloni ,&nbsp;Gary S. Collins ,&nbsp;Lauren E. Ethridge ,&nbsp;Jean Gotman ,&nbsp;Akio Ikeda ,&nbsp;Philippa J. Karoly ,&nbsp;William Z. Potter ,&nbsp;Stephan Rampp ,&nbsp;Margitta Seeck ,&nbsp;Sándor Beniczky","doi":"10.1016/j.clinph.2025.2110777","DOIUrl":"10.1016/j.clinph.2025.2110777","url":null,"abstract":"<div><div>Advances in digital technology, signal analysis, and data science have led to a rapid increase in papers reporting EEG-based biomarkers. However, wide heterogeneity in study design and reporting poses challenges in assessing the reliability, validity and utility of these biomarkers. In this evolving field, best practices are sometimes debated but not yet rigorously defined, and the appropriate next step is to ensure that validation-focused research manuscripts report key methodological factors that are known or suspected to influence results. To assist authors in designing and reporting validation studies of EEG biomarkers, and to help editors and regulatory bodies evaluate them, an international working group—under the auspices of the International Federation of Clinical Neurophysiology (IFCN) and in collaboration with the EQUATOR Network—developed the Guidelines for Reporting EEG/Neurophysiology Biomarker Evaluation for Application to Neurology and Neuropsychiatry (GREENBEAN). EEG biomarker validation studies are classified into four phases, similarly to therapeutic studies. Phases 1–2 are preliminary and do not constitute formal validation. Phase 3 studies provide compelling evidence of validity, while phase 4 studies assess the clinical utility and generalizability of previously validated biomarkers within real-world settings. We provide detailed definitions for each phase, along with a checklist of items to address and report. A detailed <em>Explanation and Elaboration</em> document is included in Supplementary Material with multiple examples of how to design and report EEG biomarker studies. We expect that more transparent reporting regarding experimental design and technical standards will not only enhance short-term biomarker validation efforts but will also enhance methodological research to make future efforts more efficient and effective.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110777"},"PeriodicalIF":3.7,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144314376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multivariate empirical mode decomposition reveals markers of Alzheimer’s Disease in the oscillatory response to transcranial magnetic stimulation","authors":"Davide Bernardi ,&nbsp;Elias P. Casula ,&nbsp;Lorenzo Rocchi ,&nbsp;Luciano Fadiga ,&nbsp;Giacomo Koch ,&nbsp;David Papo","doi":"10.1016/j.clinph.2025.2110756","DOIUrl":"10.1016/j.clinph.2025.2110756","url":null,"abstract":"<div><h3>Objective:</h3><div>To investigate EEG activity following transcranial magnetic stimulation (TMS) of the dorsolateral prefrontal cortex of Alzheimer’s Disease (AD) patients and control subjects using a data-driven characterization of brain oscillatory activity without prescribed frequency bands.</div></div><div><h3>Methods:</h3><div>We employed multivariate empirical mode decomposition (MEMD) to analyze the TMS-EEG response of 38 AD patients and 21 control subjects. We used the distinct features of EEG oscillatory modes to train a classification algorithm, a support vector machine.</div></div><div><h3>Results:</h3><div>AD patients exhibited a weakened slow-frequency response. Faster oscillatory modes displayed a biphasic response pattern in controls, characterized by an early increase followed by a widespread suppression, which was reduced in AD patients. Classification achieved robust discrimination performance (85%/23% true/false positive rate).</div></div><div><h3>Conclusions:</h3><div>AD causes an impairment in the oscillatory response to TMS that has distinct features in different frequency ranges. These features uncovered by MEMD could serve as an effective EEG diagnostic marker.</div></div><div><h3>Significance:</h3><div>Early detection of AD requires diagnostic tools that are both effective and accessible. Combining EEG with TMS shows great promise. Our results and method enhance TMS-EEG both as a practical diagnostic tool, and as a way to further our understanding of AD pathophysiology.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110756"},"PeriodicalIF":3.7,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144270136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of Parkinson’s disease on adaptive split-belt walking: a muscle synergy analysis","authors":"Femke Hulzinga ,&nbsp;Nicholas D’Cruz ,&nbsp;Christopher McCrum ,&nbsp;Pieter Ginis ,&nbsp;Moran Gilat ,&nbsp;Alice Nieuwboer","doi":"10.1016/j.clinph.2025.2110761","DOIUrl":"10.1016/j.clinph.2025.2110761","url":null,"abstract":"<div><h3>Objective</h3><div>People with Parkinson’s disease (PwPD) face challenges in adapting their gait to asymmetrical demands, leading to turning abnormalities.</div></div><div><h3>Methods</h3><div>We investigated the neuromuscular control underlying these adaptive gait difficulties using muscle synergy analysis, including a novel statistical parametric mapping (SPM) approach. We compared 24 PwPD with 27 age-matched controls (HC) during asymmetrical split-belt (SB) and regular tied-belt (TB) walking.</div></div><div><h3>Results</h3><div>Both groups decreased from four to three synergies during TB- versus SB-walking. When only considering the transition back to TB-walking, PwPD were unable to increase their number of synergies as quickly as HC. Assuming four synergies, we compared synergy timing across treadmill phases and groups. We observed phase effects in both legs, but no group-by-phase interactions. The synergy encompassing the tibialis anterior showed abnormal activation in PwPD in the slow leg during SB-walking (post-hoc p &lt; 0.001). Simplified neuromuscular control was related to worse adaptive performance in PwPD (r = -0.52,p = 0.009).</div></div><div><h3>Conclusion</h3><div>Although the number of synergies during adaptive walking was similar between groups, subtle within-synergy changes were apparent in PwPD.</div></div><div><h3>Significance</h3><div>This study is the first to examine the muscle synergies underlying adaptive SB-walking in PwPD, identifying impaired distal muscle activation as a potential fall risk factor in challenging gait situations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110761"},"PeriodicalIF":3.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195222","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From depression to chronic pain: Accelerated protocol and resting-state brain imaging targeting to personalize rTMS therapy.","authors":"Jean-Pascal Lefaucheur, Thibaut Mussigmann, Blanche Bapst, Benjamin Bardel","doi":"10.1016/j.clinph.2025.2110773","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2110773","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110773"},"PeriodicalIF":3.7,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sleep EEG in chronic insomnia disorder","authors":"Matteo Carpi ,&nbsp;Claudio Liguori","doi":"10.1016/j.clinph.2025.2110774","DOIUrl":"10.1016/j.clinph.2025.2110774","url":null,"abstract":"<div><div>Chronic insomnia disorder is among the most prevalent sleep disorders, and decades of research investigated about its diagnosis and treatment. Yet, the pathophysiological mechanisms underlying insomnia symptoms remain only partially understood. Contemporary conceptual frameworks characterize insomnia as a 24-hour disorder, marked by persistent physiological, cognitive, and emotional hyperarousal, resulting in distinct insomnia phenotypes. However, objective sleep assessment through traditional polysomnography provided limited insight into the mechanisms underlying insomnia disorder. In contrast, the application of advanced analytical techniques to both sleep and wake EEG recordings holds promise for this purpose, with quantitative EEG metrics and sleep microstructure features increasingly recognized as potential biomarkers of insomnia pathophysiology and symptom expression. On the centenary of the first EEG recordings, this narrative review aims to frame and summarize current evidence on EEG applications in insomnia research within the context of modern clinical models. After reviewing contributions from EEG studies conducted during both wakefulness and sleep in characterizing hyperarousal, sleep instability, and sleep misperception, recent findings on EEG-based markers of insomnia treatment response are presented. Finally, directions for future EEG research on insomnia are proposed, building on past achievements and advancing toward precision treatment and clinical translation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110774"},"PeriodicalIF":3.7,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Extraction and analysis of abnormal EEG features in children with amblyopia","authors":"Xiaoke Niu ,&nbsp;Jinxiong Zhang ,&nbsp;Yanyan Peng ,&nbsp;Ying Kong ,&nbsp;Yadong Li ,&nbsp;Yonghao Han ,&nbsp;Li Shi ,&nbsp;Guangying Zheng","doi":"10.1016/j.clinph.2025.2110765","DOIUrl":"10.1016/j.clinph.2025.2110765","url":null,"abstract":"<div><h3>Objective</h3><div>Early and accurate diagnosis of amblyopia is crucial for the healthy development of children. Existing clinical diagnostic methods rely on patient cooperation, which can easily lead to misdiagnosis. The commonly used features derived from visual evoked potentials (VEP) only provided limited information for characterizing the whole brain, highlighting the need for integrating additional data sources, such as brain network metrics, to achieve a more comprehensive understanding.</div></div><div><h3>Methods</h3><div>We extracted 488 features from 64-channel EEG data recorded from thirty amblyopic children. The features mainly derived from a weighted functional brain network based on coherence across different frequency bands. Feature selection and linear classification techniques were employed to assess their effectiveness in distinguishing amblyopia from normal children.</div></div><div><h3>Results</h3><div>Abnormal EEG features were distributed not only in the occipital lobe but also in non-visual regions, with a higher prevalence in the alpha and beta bands. Their decoding performance surpassed traditional VEP features, and their combination achieved the highest accuracy (89.00%). Moreover, features beyond the occipital lobe exhibited limited decoding performance when considered individually, yet they still have an obvious contribution.</div></div><div><h3>Conclusions</h3><div>The study identified novel abnormal EEG features associated with amblyopia and demonstrated the potential of multi-channel EEG recordings to assist in the diagnosis of amblyopia.</div></div><div><h3>Significance</h3><div>The study suggests amblyopia may impair more abilities beyond visual cognition and further provides objective biomarkers for diagnosing amblyopia, which is essential for effective treatment.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110765"},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characteristics of ipsilateral corticomotor pathways in people with cervical Spinal Cord injury.","authors":"Jia Liu, Madeline Cantu, Kyle O'Laughlin, David Cunningham, Akhil Mohan, Gail F Forrest, Steven Kirshblum, Kevin Kilgore, Anne Bryden, Svetlana Pundik, Tarun Arora, Gregory Nemunaitis, Francois Bethoux, Xiaofeng Wang, M Kristi Henzel, Ela B Plow","doi":"10.1016/j.clinph.2025.2110762","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2110762","url":null,"abstract":"<p><strong>Objective: </strong>Understanding motor neurophysiology is important for developing effective upper limb treatments for people with tetraplegia following cervical spinal cord injury (SCI). While literature has primarily focused on contralateral motor pathways, neurophysiology of ipsilateral pathways remains largely unexplored in tetraplegia. We aimed to investigate ipsilateral physiology and its relationship to upper limb function in individuals with tetraplegia.</p><p><strong>Methods: </strong>Twenty-three individuals with tetraplegia and 24 age-matched controls underwent transcranial magnetic stimulation to assess ipsilateral and contralateral motor physiology in the biceps muscle of the weaker arm. We also evaluated upper limb function and spasticity in tetraplegia.</p><p><strong>Results: </strong>There were no differences in ipsilateral motor evoked potential (iMEP) features (amplitudes, onsets, offsets, durations, and areas) between participants with tetraplegia and controls (all p > 0.05). However, participants with tetraplegia who had larger iMEP amplitudes also had larger contralateral MEP amplitudes (p = 0.008) and better proximal arm motor function (p = 0.031).</p><p><strong>Conclusion: </strong>Ipsilateral motor physiology is associated with contralateral physiology and proximal arm motor function in tetraplegia.</p><p><strong>Significance: </strong>Ipsilateral pathways may play a role in proximal arm function in tetraplegia. However, injury-specific adaptations were missed due to preserved biceps strength in our sample. Future studies should investigate iMEPs in non-preserved muscles to establish injury-specific relevance for rehabilitation.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110762"},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}