Clinical Neurophysiology最新文献_第3页

Extraction and analysis of abnormal EEG features in children with amblyopia 弱视儿童异常脑电图特征的提取与分析

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-27 DOI: 10.1016/j.clinph.2025.2110765

Xiaoke Niu , Jinxiong Zhang , Yanyan Peng , Ying Kong , Yadong Li , Yonghao Han , Li Shi , Guangying Zheng

{"title":"Extraction and analysis of abnormal EEG features in children with amblyopia","authors":"Xiaoke Niu , Jinxiong Zhang , Yanyan Peng , Ying Kong , Yadong Li , Yonghao Han , Li Shi , Guangying Zheng","doi":"10.1016/j.clinph.2025.2110765","DOIUrl":"10.1016/j.clinph.2025.2110765","url":null,"abstract":"<div><h3>Objective</h3><div>Early and accurate diagnosis of amblyopia is crucial for the healthy development of children. Existing clinical diagnostic methods rely on patient cooperation, which can easily lead to misdiagnosis. The commonly used features derived from visual evoked potentials (VEP) only provided limited information for characterizing the whole brain, highlighting the need for integrating additional data sources, such as brain network metrics, to achieve a more comprehensive understanding.</div></div><div><h3>Methods</h3><div>We extracted 488 features from 64-channel EEG data recorded from thirty amblyopic children. The features mainly derived from a weighted functional brain network based on coherence across different frequency bands. Feature selection and linear classification techniques were employed to assess their effectiveness in distinguishing amblyopia from normal children.</div></div><div><h3>Results</h3><div>Abnormal EEG features were distributed not only in the occipital lobe but also in non-visual regions, with a higher prevalence in the alpha and beta bands. Their decoding performance surpassed traditional VEP features, and their combination achieved the highest accuracy (89.00%). Moreover, features beyond the occipital lobe exhibited limited decoding performance when considered individually, yet they still have an obvious contribution.</div></div><div><h3>Conclusions</h3><div>The study identified novel abnormal EEG features associated with amblyopia and demonstrated the potential of multi-channel EEG recordings to assist in the diagnosis of amblyopia.</div></div><div><h3>Significance</h3><div>The study suggests amblyopia may impair more abilities beyond visual cognition and further provides objective biomarkers for diagnosing amblyopia, which is essential for effective treatment.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110765"},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144185086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characteristics of ipsilateral corticomotor pathways in people with cervical Spinal Cord injury. 颈脊髓损伤患者同侧皮质运动通路的特征。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-27 DOI: 10.1016/j.clinph.2025.2110762

Jia Liu, Madeline Cantu, Kyle O'Laughlin, David Cunningham, Akhil Mohan, Gail F Forrest, Steven Kirshblum, Kevin Kilgore, Anne Bryden, Svetlana Pundik, Tarun Arora, Gregory Nemunaitis, Francois Bethoux, Xiaofeng Wang, M Kristi Henzel, Ela B Plow

{"title":"Characteristics of ipsilateral corticomotor pathways in people with cervical Spinal Cord injury.","authors":"Jia Liu, Madeline Cantu, Kyle O'Laughlin, David Cunningham, Akhil Mohan, Gail F Forrest, Steven Kirshblum, Kevin Kilgore, Anne Bryden, Svetlana Pundik, Tarun Arora, Gregory Nemunaitis, Francois Bethoux, Xiaofeng Wang, M Kristi Henzel, Ela B Plow","doi":"10.1016/j.clinph.2025.2110762","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2110762","url":null,"abstract":"<p><strong>Objective: </strong>Understanding motor neurophysiology is important for developing effective upper limb treatments for people with tetraplegia following cervical spinal cord injury (SCI). While literature has primarily focused on contralateral motor pathways, neurophysiology of ipsilateral pathways remains largely unexplored in tetraplegia. We aimed to investigate ipsilateral physiology and its relationship to upper limb function in individuals with tetraplegia.</p><p><strong>Methods: </strong>Twenty-three individuals with tetraplegia and 24 age-matched controls underwent transcranial magnetic stimulation to assess ipsilateral and contralateral motor physiology in the biceps muscle of the weaker arm. We also evaluated upper limb function and spasticity in tetraplegia.</p><p><strong>Results: </strong>There were no differences in ipsilateral motor evoked potential (iMEP) features (amplitudes, onsets, offsets, durations, and areas) between participants with tetraplegia and controls (all p > 0.05). However, participants with tetraplegia who had larger iMEP amplitudes also had larger contralateral MEP amplitudes (p = 0.008) and better proximal arm motor function (p = 0.031).</p><p><strong>Conclusion: </strong>Ipsilateral motor physiology is associated with contralateral physiology and proximal arm motor function in tetraplegia.</p><p><strong>Significance: </strong>Ipsilateral pathways may play a role in proximal arm function in tetraplegia. However, injury-specific adaptations were missed due to preserved biceps strength in our sample. Future studies should investigate iMEPs in non-preserved muscles to establish injury-specific relevance for rehabilitation.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110762"},"PeriodicalIF":3.7,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144316057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Central auditory processing deficits in essential tremor 特发性震颤的中枢性听觉处理缺陷

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-26 DOI: 10.1016/j.clinph.2025.2110764

Preetie Shetty Akkunje , Belur Keshavaprasad Yamini , Ravi Yadav , Shantala Hegde , Aravind Kumar Rajasekaran , Pradeep Yuvaraj , Prashasti Prakash Poovaiah , Parthipulli Vasuki Prathyusha , Kandavel Thennarasu , Nagarajarao Shivashankar , Pramod Kumar Pal

{"title":"Central auditory processing deficits in essential tremor","authors":"Preetie Shetty Akkunje , Belur Keshavaprasad Yamini , Ravi Yadav , Shantala Hegde , Aravind Kumar Rajasekaran , Pradeep Yuvaraj , Prashasti Prakash Poovaiah , Parthipulli Vasuki Prathyusha , Kandavel Thennarasu , Nagarajarao Shivashankar , Pramod Kumar Pal","doi":"10.1016/j.clinph.2025.2110764","DOIUrl":"10.1016/j.clinph.2025.2110764","url":null,"abstract":"<div><h3>Introduction</h3><div>Central auditory processing (CAP) deficits are is emerging heterogeneous non-motor symptoms of essential tremor (ET). This study characterized CAP abilities of ET and examined correlations with tremor onset age and severity.</div></div><div><h3>Methods</h3><div>In this prospective cross-sectional study, CAP in ET participants was compared to age, gender, and education-matched healthy controls (HC). Tremor severity was assessed using Fahn-Tolosa-Marin rating scale. CAP was evaluated using the gap in noise (GIN) test, and auditory evoked potentials [Late latency response (LLR) and P300]. LLR parameters (P1-N1-P2-N2) were measured using speech stimulus at Cz, while P300 parameters (P3b) were recorded using both tonal & speech stimuli at Fz, Cz, and Pz.</div></div><div><h3>Results</h3><div>ET participants showed significantly poorer GIN compared to HC. LLR revealed shorter N2 latencies, while P3b showed prolonged latencies and smaller amplitudes at Fz, Cz, and Pz for both tonal and speech stimuli. GIN parameters correlated with tremor onset and severity, while P3b (Fz) correlated with tremor onset age.</div></div><div><h3>Conclusion</h3><div>Findings indicate poor temporal resolution and higher cognitive sensory deficits in auditory processing in ET, implicating the involvement of multiple cortical and subcortical circuits.</div></div><div><h3>Significance</h3><div>These findings strengthen evidence of non-motor involvement in ET, highlighting auditory processing as a potential clinical attention.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110764"},"PeriodicalIF":3.7,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Force control deficits in rapid eye movement behavior disorder and Parkinson’s disease 快速眼动行为障碍和帕金森病的力控制缺陷

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110763

Emily R. Tobin , Stefan Delmas , Joongsuk J. Kim , Jessica C. Hubbard , Basma Yacoubi , XiangYang Lou , Michael F. Presti , Allison Kraus , Richard B. Berry , Michael S. Jaffee , Evangelos A. Christou , David E. Vaillancourt

{"title":"Force control deficits in rapid eye movement behavior disorder and Parkinson’s disease","authors":"Emily R. Tobin , Stefan Delmas , Joongsuk J. Kim , Jessica C. Hubbard , Basma Yacoubi , XiangYang Lou , Michael F. Presti , Allison Kraus , Richard B. Berry , Michael S. Jaffee , Evangelos A. Christou , David E. Vaillancourt","doi":"10.1016/j.clinph.2025.2110763","DOIUrl":"10.1016/j.clinph.2025.2110763","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to determine if there are deficits in force variability, force increase, force decrease and force errors in rapid eye movement behavior disorder (RBD) using established force control paradigms.</div></div><div><h3>Methods</h3><div>A cohort of 27 controls, 37 RBD and 37 early-stage Parkinson’s disease (PD) were investigated. Individuals completed constant force and ballistic force control for the finger and ankle.</div></div><div><h3>Results</h3><div>There was greater force variability in RBD compared with controls and PD during the constant force tasks (p < 0.05). Additionally, we split the RBD group into those with mild and moderate motor impairments and found both groups had higher force variability compared with controls (p < 0.05). PD were slower at increasing and decreasing force (p < 0.05) and this was not observed in the RBD group.</div></div><div><h3>Conclusion</h3><div>These findings provide new evidence that force variability may be one of the earliest markers of motor dysfunction in RBD before a subsequent diagnosis of neurological disease.</div></div><div><h3>Significance</h3><div>These findings provide new and important insights into the motor physiological changes in force control in RBD and PD, which may inform future biomarker studies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110763"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144213062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110768

Thibaut Mussigmann , Benjamin Bardel , Jean-Pascal Lefaucheur

{"title":"Expectations related to the use of theta burst stimulation protocols for pain relief. A systematic review","authors":"Thibaut Mussigmann , Benjamin Bardel , Jean-Pascal Lefaucheur","doi":"10.1016/j.clinph.2025.2110768","DOIUrl":"10.1016/j.clinph.2025.2110768","url":null,"abstract":"<div><div>Pain treatment by repetitive transcranial magnetic stimulation (rTMS) of the primary motor cortex (M1) is generally based on the conventional high-frequency (HF) paradigm. Newer theta-burst stimulation (TBS) paradigms are increasingly being used instead of HF-rTMS in various therapeutic applications, such as the treatment of depression. The literature was analyzed until January 2025 to appraise the analgesic effects of various TBS protocols (intermittent TBS, iTBS, continuous TBS, cTBS, and prolonged protocols, piTBS and pcTBS) in the context of experimental pain provoked in healthy subjects or chronic pain experienced by patients. In experimental pain (19 articles), analgesic effects were mainly produced by pcTBS of M1. Conversely, in chronic pain (19 articles), pain was rather relieved by iTBS of M1 used alone or for priming HF-rTMS. However, the data reported to date are too few to conclude on the interest of iTBS compared to HF-rTMS. Shorter iTBS sessions open up prospects for “accelerated” procedures, expected in the field of pain. However, it will be necessary to precisely control the stimulation parameters (e.g. the number of pulses delivered per session per day or the interval between sessions) and to evaluate their impact on cortical excitability and connectivity.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110768"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144306766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Utility of the combination of median nerve SEPs and auditory brainstem responses for diagnosing Bickerstaff brainstem encephalitis 正中神经sep和听脑干反应联合诊断比克斯塔夫脑干脑炎的应用

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110766

Takamichi Kanbayashi , Hisao Kamiya , Chizuko Oishi , Hiroshi Tsukamoto , Yuki Hatanaka , Shunsuke Kobayashi , Masahiro Sonoo

{"title":"Utility of the combination of median nerve SEPs and auditory brainstem responses for diagnosing Bickerstaff brainstem encephalitis","authors":"Takamichi Kanbayashi , Hisao Kamiya , Chizuko Oishi , Hiroshi Tsukamoto , Yuki Hatanaka , Shunsuke Kobayashi , Masahiro Sonoo","doi":"10.1016/j.clinph.2025.2110766","DOIUrl":"10.1016/j.clinph.2025.2110766","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the utility of median nerve somatosensory evoked potentials (SEPs) and auditory brainstem responses (ABRs) in the early diagnosis of Bickerstaff brainstem encephalitis (BBE).</div></div><div><h3>Methods</h3><div>Data from patients diagnosed with BBE between 2001 and 2022 were extracted. Patients who underwent SEPs and ABRs within two weeks of onset were included. Normal P13/14 onset (P13/14o) latency with lost or depressed N20, or with prolonged P13/14o-N20 onset interval, was interpreted as indicating an intracranial lesion. The P14b subcomponent, which has been attributed to the thalamocortical tract, was also evaluated.</div></div><div><h3>Results</h3><div>Fourteen patients were identified, all with normal brain MRI. Abnormal SEPs indicating intracranial lesion were observed in 12 patients (86 %). Among them, P14b was identified in six patients. ABRs were abnormal in only three patients (21 %). Normal ABRs with abnormal SEPs were observed in 11 patients (79 %).</div></div><div><h3>Conclusions</h3><div>The combination of abnormal median nerve SEPs and normal ABRs was a frequent finding in patients with BBE. Impaired cortical SEPs with intact P14b as well as normal ABRs may suggest that the consciousness disturbance in BBE is mainly of supratentorial origin.</div></div><div><h3>Significance</h3><div>Evaluation of median nerve SEPs and ABRs is promising for the early diagnosis of BBE.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110766"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144240995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-time detection of absence seizures 实时检测缺勤发作

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110771

Simon G.J. Klunder , Valentina Barone , Michel J.A.M. van Putten , Johannes P. van Dijk

{"title":"Real-time detection of absence seizures","authors":"Simon G.J. Klunder , Valentina Barone , Michel J.A.M. van Putten , Johannes P. van Dijk","doi":"10.1016/j.clinph.2025.2110771","DOIUrl":"10.1016/j.clinph.2025.2110771","url":null,"abstract":"<div><h3>Objective</h3><div>Absence seizures are characterized by changes in attention, potentially leading to hazardous situations. We developed a real-time seizure detection algorithm for online detection of absences. Our aim is to integrate this algorithm into an assessment application, enabling the measurement of attention during absences.</div></div><div><h3>Methods</h3><div>Our algorithm uses a continuous wavelet transform of single-channel EEG data. We tested the algorithm offline on 22 continuous 24-hour EEG recordings of pediatric patients with absences. We externally validated our algorithm with 49 routine EEGs and twelve ambulatory recordings. To quantify the algorithm’s performance, we determined sensitivity, false positive rate, time to first detection and F1 score.</div></div><div><h3>Results</h3><div>In our test dataset, we obtained an average sensitivity of 97.9 %, a false positive rate of 1.20/h and an F1 score of 0.82. Except for one patient, the median time until detection was <em><</em>2 s. In our validation set, an average sensitivity of 95 % and an F1 score of 0.88 was reached. The average false positive rate was 5.6/h and 4.5/h for the routine and ambulatory recordings, respectively. The median time until first detection was 1.1 s.</div></div><div><h3>Conclusions</h3><div>Our algorithm demonstrates fast detection of absence seizures with a high sensitivity, making it suitable for integration in a computerized reaction time task. The high false positive rate indicates the importance of a careful review of the results.</div></div><div><h3>Significance</h3><div>The algorithm has the potential to play a useful role in the advancement of clinical and research applications aimed at studying transient impaired attention during absences.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110771"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurophysiological responses to phonological and temporal regularities in speech in dyslexic and typical readers 阅读困难和典型读者对语音和时间规律的神经生理反应

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110772

Alexandra K. Emmendorfer , Bernadette M. Jansma , Sonja A. Kotz , Milene Bonte

{"title":"Neurophysiological responses to phonological and temporal regularities in speech in dyslexic and typical readers","authors":"Alexandra K. Emmendorfer , Bernadette M. Jansma , Sonja A. Kotz , Milene Bonte","doi":"10.1016/j.clinph.2025.2110772","DOIUrl":"10.1016/j.clinph.2025.2110772","url":null,"abstract":"<div><h3>Objective</h3><div>Sensitivity to sublexical speech features is important for successful reading development. Here we assessed the processing of formal (phonological) and temporal (syllable stress) sublexical speech regularities in typical and dyslexic readers.</div></div><div><h3>Methods</h3><div>We tested Dutch-speaking, typical and dyslexic adult readers in a passive EEG oddball paradigm, manipulating phonotactic probability (formal) and syllable stress (temporal) in Dutch pseudowords. We assessed the mismatch negativity (MMN) as a marker for experience-dependent change detection, as well as the associated phase-reset in the theta frequency band.</div></div><div><h3>Results</h3><div>Both deviant types elicited an MMN. Dyslexic readers exhibited reduced neural sensitivity to phonotactic, but not to stress regularities. Time-frequency analyses suggest distinct processes underlying change detection for different deviant types, with increased delta/theta inter-trial coherence (ITC) for formal deviants, which was enhanced in dyslexic readers, and a decrease for temporal deviants, which did not differ between groups.</div></div><div><h3>Conclusion</h3><div>Results suggest atypical sensitivity to phonological but not temporal speech regularities in dyslexic readers, and distinct oscillatory correlates underlying change detection for different deviant types.</div></div><div><h3>Significance</h3><div>This is the first study to simultaneously assess neural sensitivity to phonological and temporal regularities in Dutch adult dyslexic readers and highlights distinct change detection for different sublexical features.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110772"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144204358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Using high-frequency oscillation to detect acute brain injury in extracorporeal membrane oxygenation supported patients 高频振荡检测体外膜氧合患者急性脑损伤

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110769

Mingfeng Cao , Shivalika Khanduja , Winnie Liu , Shi Nan Feng , Jin Kook Kang , Khalil S. Husari , Eva Katharina Ritzl , Glenn Whitman , Nitish Thakor , Sung-Min Cho

{"title":"Using high-frequency oscillation to detect acute brain injury in extracorporeal membrane oxygenation supported patients","authors":"Mingfeng Cao , Shivalika Khanduja , Winnie Liu , Shi Nan Feng , Jin Kook Kang , Khalil S. Husari , Eva Katharina Ritzl , Glenn Whitman , Nitish Thakor , Sung-Min Cho","doi":"10.1016/j.clinph.2025.2110769","DOIUrl":"10.1016/j.clinph.2025.2110769","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to utilize HFO analysis to enhance existing SSEP modality and develop it as a bedside diagnostic tool for acute brain injury (ABI) detection in Extracorporeal Membrane Oxygenation (ECMO) patients.</div></div><div><h3>Significance</h3><div>Timely diagnosis of ABI in ECMO patients is challenging due to logistical complexities with computed tomography (CT) and magnetic resonance imaging (MRI). Integrating time–frequency analysis into routine SSEP monitoring for early ABI detection can facilitate timely medical decisions.</div></div><div><h3>Method</h3><div>Consecutive SSEP data were collected from Johns Hopkins Intensive Care Units (ICUs), including 31 ECMO and 45 non-ECMO patients from 2016 to 2022. ABIs were determined using CT and MRI as clinically indicated. Using wavelet techniques, two SSEP-HFO components were quantified: HFOL (80–200 Hz) and HFOH (200–600 Hz), which were later fed to a Support Vector Machine (SVM) with a linear kernel.</div></div><div><h3>Result</h3><div>ECMO patients with ABI (N = 22) exhibited suppressed HFOH (Median = −9.09, Interquartile Range (IQR) = [ −13.5; −4.73] dB) compared to patients without (N = 9, Median = −4.39, IQR = [−6.35; −3.28] dB, P = 0.035). The SVM classifier achieved an accuracy of 75 % and a sensitivity of 82 % for detecting ABI, outperforming SSEP-N20.</div></div><div><h3>Conclusion</h3><div>SSEP-HFO can potentially improve early detection of ABI in ECMO patients at the bedside.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110769"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Short-interval intracortical inhibition and facilitation in amyotrophic lateral sclerosis related to disease phenotype 肌萎缩性侧索硬化症与疾病表型相关的短间隔皮质内抑制和促进

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-25 DOI: 10.1016/j.clinph.2025.2110770

Hatice Tankisi , Anna Bystrup Jacobsen , Gaia Fanella , Bülent Cengiz , Hasan Kılınç , Jose Manuel Matamala , Javier Moreno-Roco , Agessandro Abrahao , Lorne Zinman , Martin Koltzenburg , James Howells , Gintaute Samusyte , Friedemann Awiszus , Hugh Bostock

{"title":"Short-interval intracortical inhibition and facilitation in amyotrophic lateral sclerosis related to disease phenotype","authors":"Hatice Tankisi , Anna Bystrup Jacobsen , Gaia Fanella , Bülent Cengiz , Hasan Kılınç , Jose Manuel Matamala , Javier Moreno-Roco , Agessandro Abrahao , Lorne Zinman , Martin Koltzenburg , James Howells , Gintaute Samusyte , Friedemann Awiszus , Hugh Bostock","doi":"10.1016/j.clinph.2025.2110770","DOIUrl":"10.1016/j.clinph.2025.2110770","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between short-interval intracortical inhibition (SICI), short-interval intracortical facilitation (SICF) and amyotrophic lateral sclerosis (ALS) phenotype, using threshold-tracking transcranial magnetic stimulation (TMS).</div></div><div><h3>Methods</h3><div>A new paired-pulse TMS protocol was applied to 49 patients with ALS and 49 age-matched healthy controls. Motor evoked potentials (MEPs) were recorded from first dorsal interosseus muscle, while paired pulses were delivered at interstimulus intervals (ISI) of 1.0, 2.5 or 3.0 ms, with stimuli related to the resting motor threshold for a 200 µV MEP. For each ISI, 6 SICI and 3 SICF pulse pairs with different conditioning stimuli were randomised and interleaved with test-alone stimuli.</div></div><div><h3>Results</h3><div>ALS phenotypes were characterised as Pyramidal (<em>n</em> = 12, with prominent upper motor neuron signs), Classic (<em>n</em> = 20, with limb onset), or Bulbar (<em>n</em> = 17). Compared with healthy controls, Bulbar patients had significantly less inhibition at all ISIs, while SICI in Pyramidal patients was normal, and in Classic patients intermediate. The only SICF abnormalities independent of the changes in SICI were less facilitation in Pyramidal patients at ISIs 1 and 3 ms.</div></div><div><h3>Conclusion</h3><div>Changes in SICI and SICF depend on ALS phenotype.</div></div><div><h3>Significance</h3><div>ALS phenotypes should be matched between treatment and placebo arms of clinical trials.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110770"},"PeriodicalIF":3.7,"publicationDate":"2025-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144223070","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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