Clinical Neurophysiology最新文献_第3页

Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy 新生儿脑病足月新生儿与血糖异常相关的神经生理变化

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-09 DOI: 10.1016/j.clinph.2025.2111002

Jessy Parokaran Varghese , Elana F Pinchefsky , Saeed Montazeri , Daphne Kamino , Cecil D Hahn , Sampsa Vanhatalo , Emily WY Tam

{"title":"Neurophysiological changes associated with dysglycemia in term neonates with neonatal encephalopathy","authors":"Jessy Parokaran Varghese , Elana F Pinchefsky , Saeed Montazeri , Daphne Kamino , Cecil D Hahn , Sampsa Vanhatalo , Emily WY Tam","doi":"10.1016/j.clinph.2025.2111002","DOIUrl":"10.1016/j.clinph.2025.2111002","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the relationship between hypo/hyperglycemia and EEG measures in term neonates with neonatal encephalopathy (NE) treated with therapeutic hypothermia (TH).</div></div><div><h3>Methods</h3><div>Ninety-six neonates underwent concurrent continuous glucose monitoring (CGM) and EEG for 48 h within the first 72 h of life. Five-minute epochs of hypoglycemia (≤2.6 mmol/L; ≤47 mg/dL) and hyperglycemia (>10.1 mmol/L; >182 mg/dL) were identified. Continuous EEG data was segmented into 5-min epochs corresponding to 5-min CGM data. Visual EEG background score and 22 computational EEG measures were estimated and their relationship to dysglycemia was assessed after adjusting for hypoxia–ischemia severity and multiple testing.</div></div><div><h3>Results</h3><div>Among the 96 neonates, 12 had hypoglycemia, 16 had hyperglycemia, including 1 with both during the recording period. In the adjusted analyses, hyperglycemic epochs were associated with worse visual background scores (1.2, 95 %CI 0.51–1.89, q = 0.003) and 11 computational EEG measures. In contrast, hypoglycemic epochs were not associated with a significant change in visual background scores (−0.28, 95 %CI −0.66 − −0.10, q = 0.549), and were only associated with one computational EEG measure.</div></div><div><h3>Conclusions</h3><div>Hyperglycemia is temporally associated with changes in brain function in term neonates with NE treated with TH.</div></div><div><h3>Significance</h3><div>This temporal relationship suggests high glucose levels may contribute directly to brain injury after NE.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111002"},"PeriodicalIF":3.6,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145095730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive nerve stimulation normalization after FcRn inhibitor therapy in refractory myasthenia gravis: A case report FcRn抑制剂治疗难治性重症肌无力后重复神经刺激正常化1例报告

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-09 DOI: 10.1016/j.clinph.2025.2111001

Rajiv Wijesinghe, Richard Yitong Shao, Gaven Lin, Matthew Silsby

引用次数: 0

Electroencephalogram in children with hepatic encephalopathy: towards a new classification? 肝性脑病患儿脑电图：迈向新的分类？

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-05 DOI: 10.1016/j.clinph.2025.2111000

Delphine Taussig , Claire Dussaule , Emmanuel Jacquemin , Marion Almes , Viviane Bouilleret , Véronique Sébille

{"title":"Electroencephalogram in children with hepatic encephalopathy: towards a new classification?","authors":"Delphine Taussig , Claire Dussaule , Emmanuel Jacquemin , Marion Almes , Viviane Bouilleret , Véronique Sébille","doi":"10.1016/j.clinph.2025.2111000","DOIUrl":"10.1016/j.clinph.2025.2111000","url":null,"abstract":"<div><h3>Objective</h3><div>Diagnosis of hepatic encephalopathy (HE) is challenging in children. The electroencephalogram (EEG) is an easily accessible and pivotal tool but no satisfactory classification is currently available.</div></div><div><h3>Methods</h3><div>We studied inter-observer agreement with Gwet’s AC2 coefficient with quadratic weights, for <span><span>Navelet et al.’s (1990)</span></span> classification (1990) in EEGs successively performed for chronic or acute liver disease in a reference centre. We analysed reasons for discordance and proposed a new classification. We studied the association between both classification, the neurological impairment and hepatic biological dysfunction.</div></div><div><h3>Results</h3><div>171 EEGs were analysed. Slowing of the dominant rhythm and loss of reactivity characterized the pathological awake EEGs. Using the Navelet classification, there was a very high inter-rater agreement beyond chance. We have refined it with Children’s Hepatic Encephalopathy EEG Recording Scale (CHEERS). Inter-rater agreement for the CHEERS classification in 27 supplementary EEGs was almost perfect beyond chance. Association between each EEG scale and the neurological impairment and hepatic biological dysfunction was significant.</div></div><div><h3>Conclusion</h3><div>Our proposed classification is reliable in detailing abnormalities when suspecting HE in children.</div></div><div><h3>Significance</h3><div>The next step will be to validate the classification in an external cohort by independent readers and to prove its utility in detecting the first stages of deterioration of hepatic function.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2111000"},"PeriodicalIF":3.6,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145045382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A brake on the blink: EEG antecedents of movement suppression and urge to move. 眨眼的刹车：运动抑制和运动冲动的脑电图前因。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.2110997

Antonio Ivano Triggiani, Lucrezia Liuzzi, Kaya Scheman, Mark Hallett

{"title":"A brake on the blink: EEG antecedents of movement suppression and urge to move.","authors":"Antonio Ivano Triggiani, Lucrezia Liuzzi, Kaya Scheman, Mark Hallett","doi":"10.1016/j.clinph.2025.2110997","DOIUrl":"https://doi.org/10.1016/j.clinph.2025.2110997","url":null,"abstract":"<p><strong>Objective: </strong>To compare brain activity before voluntary movement and before the same movement when it was released from suppression. This study examined the Bereitschaftspotential (BP) and beta band event-related desynchronization (bERD) during active blink suppression, contrasting these with voluntary blinking, where these EEG correlates of motor preparation are well-established.</p><p><strong>Methods: </strong>Fifteen healthy adults performed voluntary blink and blink suppression-release tasks with EEG recording. Time-locked analyses focused on BP and bERD for each condition.</p><p><strong>Results: </strong>Voluntary blinks showed a robust negative BP, which was markedly attenuated after a period of active suppression. Overall bERD did not significantly differ, but low-frequency bERD mirrored BP activity, while high-frequency bERD showed typical desynchronization.</p><p><strong>Conclusion: </strong>The dissociation between BP and bERD suggests distinct neurophysiological mechanisms related to the voluntary control and urge to move in fundamental actions like blinks, involving active suppression of typical motor preparation rather than just absent activation. This insight into the neural control of suppressing even basic motor acts may be relevant to understanding conditions characterized by difficulties in action suppression, such as tic disorders.</p><p><strong>Significance: </strong>This study offers novel insights into the neural correlates of suppressing seemingly unavoidable physiological responses, enhancing our understanding of inhibitory control and potentially impacting the study of conditions with action suppression deficits.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"2110997"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008122","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to the letter by Dr. Jongsuk Choi: trigemino-vocal reflex: A potential indicator of brainstem integration 对Jongsuk Choi博士来信的回复：三叉神经-声音反射：脑干整合的潜在指标。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.2110810

Javier Urriza , Isabel Fernandez-Conejero , Kathleen Seidel , Sedat Ulkatan

引用次数: 0

Calcium-dependent nonlinearity describes the after-effects of different patterns of theta-burst TMS 钙依赖性非线性描述了不同模式的脉冲经颅磁刺激的后效。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.04.001

Ke Ma , Sung Wook Chung , John C. Rothwell , Masashi Hamada , Stephan M. Goetz

{"title":"Calcium-dependent nonlinearity describes the after-effects of different patterns of theta-burst TMS","authors":"Ke Ma , Sung Wook Chung , John C. Rothwell , Masashi Hamada , Stephan M. Goetz","doi":"10.1016/j.clinph.2025.04.001","DOIUrl":"10.1016/j.clinph.2025.04.001","url":null,"abstract":"<div><h3>Objective</h3><div>Optimisation of transcranial magnetic stimulation protocol parameters can potentially improve their efficacy through theoretical mathematical models. This study aims to develop an elaborate but still parsimonious quantitative model for understanding the dosage-dependency of Theta-Burst Stimulation (TBS).</div></div><div><h3>Methods</h3><div><span>We propose a calcium-dependent nonlinear model that uses Michaelis–Menten kinetics to represent competing molecular pathways in postsynaptic neurons during TBS intervention. The model integrates four subsystems: calcium dynamics, modulation substances, </span>MEP learning, and metaplasticity, with a particular focus on the interaction between facilitatory and inhibitory signalling cascades.</div></div><div><h3>Results</h3><div>Our model successfully reproduces experimental findings from various TBS protocols, including the reversal of after-effects observed in prolonged stimulation. The simulation results suggest that the competing molecular pathways with distinct calcium sensitivities and temporal dynamics determine the direction of after-effects.</div></div><div><h3>Conclusions</h3><div>This proposed model represents a substantial advancement in understanding TBS-induced neuromodulation by providing testable predictions for untested TBS protocols and offers complementary insights into the underlying neural mechanisms.</div></div><div><h3>Significance</h3><div>This model offers a basic framework for potentially incorporating complex, nonlinear relationships between TBS parameters and after-effects under various neurological and psychiatric conditions. It also provides a valuable tool for later protocol optimisation and guiding future experimental designs.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"177 ","pages":"Article 2010713"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143984626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Trigemino-Vocal Reflex: A potential indicator of brainstem integration 三叉神经-声音反射：脑干整合的潜在指标。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.2110796

Jongsuk Choi

引用次数: 0

Gamma activation spread reflects disease activity in amyotrophic lateral sclerosis 肌萎缩性侧索硬化症的γ激活扩散反映疾病活动。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.2110823

Michael Trubshaw , Katie Yoganathan , Chetan Gohil , Charlotte J. Stagg , Anna C. Nobre , Kevin Talbot , Mark Woolrich , Alexander G. Thompson , Martin R. Turner

{"title":"Gamma activation spread reflects disease activity in amyotrophic lateral sclerosis","authors":"Michael Trubshaw , Katie Yoganathan , Chetan Gohil , Charlotte J. Stagg , Anna C. Nobre , Kevin Talbot , Mark Woolrich , Alexander G. Thompson , Martin R. Turner","doi":"10.1016/j.clinph.2025.2110823","DOIUrl":"10.1016/j.clinph.2025.2110823","url":null,"abstract":"<div><h3>Objective</h3><div>A non-invasive measure of cerebral motor system dysfunction would be valuable as a biomarker in amyotrophic lateral sclerosis (ALS). Task-based magnetoencephalography (tMEG) measures the magnetic fields generated by cortical neuronal oscillatory activity during task performance. Gamma activations are periods of high-power and high-frequency cortical oscillations integral to motor control.</div></div><div><h3>Methods</h3><div>tMEG was undertaken during 60 bilateral isometric hand grip exercises in ALS (n = 42) and compared with healthy controls (HC, n = 33). Gamma activation spread (GAS) was estimated by calculating the number of activated regions during each 100 ms time-bin and compared statistically between groups. Gamma activation patterns were visualised by plotting each participant’s brain activity separately as a 2-dimensional video.</div></div><div><h3>Results</h3><div>There was no difference in grip strength between groups. GAS was greatly increased in the ALS group compared to HC (p < 0.001) and correlated positively with rate of ALSFRS-R progression (t = 1.35, p = 0.023) and a fine motor sub-score (t = -1.18, p = 0.047).</div></div><div><h3>Conclusions</h3><div>ALS was associated with a marked increase in regional spread of gamma frequency activation, greater in those with higher disease progression rates.</div></div><div><h3>Significance</h3><div>The regional spread of gamma activity may reflect disease activity in ALS, with potential application as an experimental medicine readout.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"177 ","pages":"Article 2110823"},"PeriodicalIF":3.6,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144559361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ipsilateral motor pathways related to proximal upper limb function in tetraplegia 四肢瘫痪患者与上肢近端功能相关的同侧运动通路。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.2110780

M. Hussain, S.D. Foglia, A.J. Nelson

引用次数: 0

The urge to blink. 想眨眼的冲动。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-09-01 DOI: 10.1016/j.clinph.2025.2110998

Josep Valls-Solé

引用次数: 0