Clinical Neurophysiology最新文献_第4页

Novel neurophysiological evidence for preserved pain habituation across chronic pain conditions 新的神经生理学证据表明，在不同的慢性疼痛条件下，疼痛习惯化都会得到保留

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-20 DOI: 10.1016/j.clinph.2024.07.007

{"title":"Novel neurophysiological evidence for preserved pain habituation across chronic pain conditions","authors":"","doi":"10.1016/j.clinph.2024.07.007","DOIUrl":"10.1016/j.clinph.2024.07.007","url":null,"abstract":"<div><h3>Objective</h3><p>The present study aimed to investigate whether subjective and objective measures of pain habituation can be used as potential markers for central sensitization across various chronic pain patients.</p></div><div><h3>Methods</h3><p>Two blocks of contact-heat stimuli were applied to a non-painful area in 93 chronic pain patients (low back pain, neuropathic pain, and complex regional pain syndrome) and 60 healthy controls (HC). Habituation of pain ratings, contact-heat evoked potentials (CHEP), and sympathetic skin responses (SSR) was measured.</p></div><div><h3>Results</h3><p>There was no significant difference in any measure of pain habituation between patients and HC. Even patients with apparent clinical signs of central sensitization showed no reduced pain habituation. However, prolonged baseline CHEP and SSR latencies (stimulation block 1) were found in patients compared to HC (CHEP: Δ-latency = 23 ms, p = 0.012; SSR: Δ-latency = 100 ms, p = 0.022).</p></div><div><h3>Conclusion</h3><p>Given the performed multimodal neurophysiological testing protocol, we provide evidence indicating that pain habituation may be preserved in patients with chronic pain and thereby be of limited use as a sensitive marker for central sensitization. These results are discussed within the framework of the complex interactions between pro- and antinociceptive mechanism as well as methodological issues. The prolonged latencies of CHEP and SSR after stimulation in non-painful areas may indicate subclinical changes in the integrity of thermo-nociceptive afferents, or a shift towards antinociceptive activity. This shift could potentially affect the relay of ascending signals.</p></div><div><h3>Significance</h3><p>Our findings challenge the prevailing views in the literature and may encourage further investigations into the peripheral and central components of pain habituation, using advanced multimodal neurophysiological techniques.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002074/pdfft?md5=4f514cb4dbaa403c123197c4cbd2c044&pid=1-s2.0-S1388245724002074-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141840754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Erratum to “TDCS for Parkinson’s disease-related pain: A randomized trial” [Clin. Neurophysiol. 161 (2024) 133-146] 对 "TDCS 治疗帕金森病相关疼痛：随机试验"[Clin. Neurophysiol.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-20 DOI: 10.1016/j.clinph.2024.07.001

引用次数: 0

Three montages for Transcranial electric stimulation in predicting the early post-surgery outcome of the facial nerve functioning. 经颅电刺激预测面神经功能术后早期疗效的三个蒙太奇。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-19 DOI: 10.1016/j.clinph.2024.07.008

Mikael Gian Andrea Izzo, Davide Rossi Sebastiano, Valentina Catanzaro, Ylenia Melillo, Ramona Togni, Elisa Visani, Jacopo Falco, Cecilia Casali, Marco Gemma, Paolo Ferroli, Annamaria Gallone, Daniele Cazzato, Grazia Devigili, Sara Alverà, Paola Lanteri

{"title":"Three montages for Transcranial electric stimulation in predicting the early post-surgery outcome of the facial nerve functioning.","authors":"Mikael Gian Andrea Izzo, Davide Rossi Sebastiano, Valentina Catanzaro, Ylenia Melillo, Ramona Togni, Elisa Visani, Jacopo Falco, Cecilia Casali, Marco Gemma, Paolo Ferroli, Annamaria Gallone, Daniele Cazzato, Grazia Devigili, Sara Alverà, Paola Lanteri","doi":"10.1016/j.clinph.2024.07.008","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.07.008","url":null,"abstract":"<p><strong>Objective: </strong>We assessed the Transcranial Electrical Stimulation (TES)-induced Corticobulbar-Motor Evoked Potentials (Cb-MEPs) evoked from Orbicularis Oculi (Oc) and Orbicularis Oris (Or) muscles with FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6/-Cz stimulation, during IntraOperative NeuroMonitoring (IONM) in 30 patients who underwent skull-base surgery.</p><p><strong>Methods: </strong>before (T0) and after (T1) the surgery, we compared the peak-to-peak amplitudes of Cb-MEPs obtained from TES with C3/C4-Cz, C5/C6-Cz and FCC5h/FCC6h-Mz. Then, we compared the response category (present, absent and peripheral) related to different montages. Finally, we classified the Cb-MEPs data from each patient for concordance with clinical outcome and we assessed the diagnostic measures for Cb-MEPs data obtained from FCC5h/FCC6h-Mz, C3/C4-Cz and C5/C6-Cz TES stimulation.</p><p><strong>Results: </strong>Both at T0 and T1, FCC5h/FCC6h-Mz stimulation evoked larger Cb-MEPs than C3/C4-Cz, less peripheral responses from direct activation of facial nerve than C5/C6-Cz. FCC5h/FCC6h-Mz stimulation showed the best accuracy and specificity of Cb-MEPs for clinical outcomes.</p><p><strong>Conclusions: </strong>FCC5h/FCC6h-Mz stimulation showed the best performances for monitoring the facial nerve functioning, maintaining excellent diagnostic measures even at low stimulus voltages.</p><p><strong>Significance: </strong>We demonstrated that FCC5h/FCC6h-Mz TES montage for Cb-MEPs in IONM has good accuracy in predicting the post-surgery outcome of facial nerve functioning.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141854960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transcranial direct current stimulation improves tardive dyskinesia in long-term hospitalized patients with chronic schizophrenia 经颅直流电刺激可改善长期住院的慢性精神分裂症患者的迟发性运动障碍。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-17 DOI: 10.1016/j.clinph.2024.07.006

{"title":"Transcranial direct current stimulation improves tardive dyskinesia in long-term hospitalized patients with chronic schizophrenia","authors":"","doi":"10.1016/j.clinph.2024.07.006","DOIUrl":"10.1016/j.clinph.2024.07.006","url":null,"abstract":"<div><h3>Objective</h3><p>This study aimed to evaluate the efficacy and safety of transcranial direct current stimulation (tDCS) in chronic schizophrenia patients with tardive dyskinesia (TD) who were long-term hospitalized.</p></div><div><h3>Methods</h3><p>Sixty-four inpatients who met the DSM-IV diagnostic criteria for schizophrenia and TD were randomly assigned to either the active (N=35) or sham (N=29) group. Treatment was given 15 times, with each session lasting for 30 min, and an intensity of 2 mA. The anode was placed on the left dorsolateral prefrontal cortex and the cathode on the right supraorbital region. Primary outcome was measured by the changes in Abnormal Involuntary Movements Scale (AIMS) score. Secondary outcomes were measured using the Positive and Negative Syndrome Scale (PANSS) and the Scale for the Assessment of Negative Symptoms (SANS). Adverse effects of tDCS were assessed with an experimenter-administered open-ended questionnaire throughout the experiment.</p></div><div><h3>Results</h3><p>Of the 64 patients, 52 (81.25%) completed the study. Compared to the sham group, patients in the active group exhibited a significant reduction in both the total AIMS score and the facial-oral subscore (<em>P</em><0.05). An improvement of at least 30% in total AIMS scores was observed in the active group (14 patients, 50%) compared to the sham group (2 patients, 8.3%) after treatment (<em>P</em><0.01). There were no between-group differences in the PANSS and SANS total scores. However, there was a significant difference between the two groups in the occurrence of the reported adverse effect of tingling sensation (<em>P</em><0.05).</p></div><div><h3>Conclusions</h3><p>TDCS may be an effective and safe treatment for improving the facial-oral motor symptoms of TD in chronically hospitalized patients with schizophrenia.</p></div><div><h3>Significance</h3><p>This study provides a novel perspective for the clinical treatment of patients with TD.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141859162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sensory intelligence for extraction of abstract auditory rules from a speech sound stream in children with cochlear implants 从人工耳蜗儿童的语音声流中提取抽象听觉规则的感官智能

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-17 DOI: 10.1016/j.clinph.2024.07.005

{"title":"Sensory intelligence for extraction of abstract auditory rules from a speech sound stream in children with cochlear implants","authors":"","doi":"10.1016/j.clinph.2024.07.005","DOIUrl":"10.1016/j.clinph.2024.07.005","url":null,"abstract":"<div><h3>Objective</h3><p>Sensory intelligence in the brain helps listeners automatically extract abstract auditory rules formed by invariant acoustic features from complex speech sound streams, presumably serving as the neural basis for speech comprehension. However, whether this intelligence is deficient in children with cochlear implants (CIs) remains unclear.</p></div><div><h3>Methods</h3><p>Mandarin Chinese monosyllables shared a flat lexical tone contour to form an abstract auditory rule but differed in other acoustic features to construct a complex speech sound stream. The abstract rule was occasionally violated by monosyllables with a rising or falling lexical tone.</p></div><div><h3>Results</h3><p>In normal hearing (NH) children, the abstract auditory rule could be extracted, as revealed by a mismatch negativity (MMN) and a late discriminative negativity (LDN). However, the MMN and LDN were only evoked in CI children with good hearing and speech performance. NH children with a higher speech perception or spatial hearing score had a greater MMN. The LDN was attenuated with increasing age in NH children.</p></div><div><h3>Conclusions</h3><p>The sensory intelligence for extraction of auditory abstract rules, associated with speech perception, is deficient in CI children. This intelligence may gradually develop during childhood and adolescence.</p></div><div><h3>Significance</h3><p>Deficient sensory intelligence in CI children may aid in understanding poor speech comprehension in complex environments.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141639958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuropathic phenotypes of type 1 diabetes are related to different signatures of magnetic resonance spectroscopy-assessed brain metabolites 1 型糖尿病的神经病理性表型与磁共振波谱评估的大脑代谢物的不同特征有关

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-16 DOI: 10.1016/j.clinph.2024.06.017

{"title":"Neuropathic phenotypes of type 1 diabetes are related to different signatures of magnetic resonance spectroscopy-assessed brain metabolites","authors":"","doi":"10.1016/j.clinph.2024.06.017","DOIUrl":"10.1016/j.clinph.2024.06.017","url":null,"abstract":"<div><h3>Objectives</h3><p>The study aimed to investigate brain metabolites in type 1 diabetes and the associations with disease characteristics. We explored the metabolic profiles predicting different neuropathic phenotypes using multiple linear regression analyses.</p></div><div><h3>Methods</h3><p>We compared brain metabolites in 55 adults with type 1 diabetes (including painful diabetic peripheral neuropathy (DPN), painless DPN, without DPN) with 20 healthy controls. Proton magnetic resonance spectroscopy measurements (N-acetylaspartate (NAA), glutamate (glu), myo-inositol (mI), and glycerophosphocholine (GPC) were obtained in ratios to creatine (cre)) from the parietal region, anterior cingulate cortex and thalamus.</p></div><div><h3>Results</h3><p>The overall diabetes group revealed decreased parietal NAA/cre compared to healthy controls (1.41 ± 0.12 vs. 1.55 ± 0.13,p < 0.001) and increased mI/cre (parietal: 0.62 ± 0.08 vs. 0.57 ± 0.07,p = 0.025, cingulate: 0.65 ± 0.08 vs. 0.60 ± 0.08,p = 0.033). Reduced NAA/cre was associated with more severe DPN (all p ≤ 0.04) whereas increased mI/cre was associated with higher hemoglobin A<sub>1c</sub> (HbA<sub>1c</sub>) (p = 0.02). Diabetes was predicted from decreased parietal NAA/cre, increased parietal ml/cre, and decreased thalamic glu/cre. DPN was predicted from decreased parietal NAA/cre and increased GPC/cre. Painful DPN was predicted from increased parietal GPC/cre and thalamic glu/cre.</p></div><div><h3>Conclusions</h3><p>Specific metabolic brain profiles were linked to the different phenotypes of diabetes, DPN and painful DPN.</p></div><div><h3>Significance</h3><p>Assessment of metabolic profiles could be relevant for detailed understanding of central neuropathy in diabetes.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001998/pdfft?md5=4afcaedcf5c628ff9517025633e1175a&pid=1-s2.0-S1388245724001998-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141643659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stochastic resonance in the sensory systems and its applications in neural prosthetics 感觉系统中的随机共振及其在神经假肢中的应用

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-11 DOI: 10.1016/j.clinph.2024.07.004

{"title":"Stochastic resonance in the sensory systems and its applications in neural prosthetics","authors":"","doi":"10.1016/j.clinph.2024.07.004","DOIUrl":"10.1016/j.clinph.2024.07.004","url":null,"abstract":"<div><p>Noise is generally considered to be detrimental. In the right conditions, however, noise can improve signal detection or information transmission. This counterintuitive phenomenon is called stochastic resonance (SR). SR has generated significant interdisciplinary interest, particularly in physics, engineering, and medical and environmental sciences. In this review, we discuss a growing empirical literature that suggests that noise at the right intensity may improve the detection and processing of auditory, sensorimotor, and visual stimuli. We focus particularly on applications of SR in sensory biology and investigate whether SR-based technologies present a pathway to improve outcomes for individuals living with sensory impairments. We conclude that there is considerable evidence supporting the application of SR in developing sensory prosthetics. However, the progression of SR-based technologies is variable across the sensory modalities. We suggest opportunities for further advancements in each modality, considering the best approaches to maximise benefits and capitalise on progress already made. Overall, SR can offer opportunities to improve existing technologies or to motivate innovations.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002025/pdfft?md5=7d4f5e0bef81c2d2f8a4b36d9f25f132&pid=1-s2.0-S1388245724002025-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141702478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The timing of sleep spindles is modulated by the respiratory cycle in humans 睡眠棘波的时间受人类呼吸周期的调节。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.06.014

{"title":"The timing of sleep spindles is modulated by the respiratory cycle in humans","authors":"","doi":"10.1016/j.clinph.2024.06.014","DOIUrl":"10.1016/j.clinph.2024.06.014","url":null,"abstract":"<div><h3>Objective</h3><p>Coupling of sleep spindles with cortical slow waves and hippocampus sharp-waves ripples is crucial for sleep-related memory consolidation. Recent literature evidenced that nasal respiration modulates neural activity in large-scale brain networks. In rodents, this respiratory drive strongly varies according to vigilance states. Whether sleep oscillations are also respiration-modulated in humans remains open. In this work, we investigated the influence of breathing on sleep spindles during non-rapid-eye-movement sleep in humans.</p></div><div><h3>Methods</h3><p>Full night polysomnography of twenty healthy participants were analysed. Spindles and slow waves were automatically detected during N2 and N3 stages. Spindle-related sigma power as well as spindle and slow wave events were analysed according to the respiratory phase.</p></div><div><h3>Results</h3><p>We found a significant coupling between both slow and fast spindles and the respiration cycle, with enhanced sigma activity and occurrence probability of spindles during the middle part of the expiration phase. A different coupling was observed for slow waves negative peaks which were rather distributed around the two respiration phase transitions.</p></div><div><h3>Conclusion</h3><p>Our findings suggest that breathing cycle influences the dynamics of brain activity during non-rapid-eye-movement sleep.</p></div><div><h3>Significance</h3><p>This coupling may enable sleep spindles to synchronize with other sleep oscillations and facilitate information transfer between distributed brain networks.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724001962/pdfft?md5=f26fcc77bfaf95206abd1ab941254b2a&pid=1-s2.0-S1388245724001962-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141726922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Tonic stretch reflex threshold as a measure of disordered motor control and spasticity – A critical review 以张力性拉伸反射阈值衡量运动控制失调和痉挛 - 综述

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.06.019

{"title":"Tonic stretch reflex threshold as a measure of disordered motor control and spasticity – A critical review","authors":"","doi":"10.1016/j.clinph.2024.06.019","DOIUrl":"10.1016/j.clinph.2024.06.019","url":null,"abstract":"<div><p>The Tonic Stretch Reflex Threshold (TSRT) is the joint angle or muscle length (λ) at which muscle activation begins. In spasticity, the TSRT abnormally lies inside the biomechanical joint range. It is determined by measuring the Dynamic Stretch Reflex Thresholds (DSRTs) by stretching the resting muscle at different velocities. The metric <em>μ</em>, characterizes the velocity-sensitivity of the DSRTs and is expressed as the time required to lengthen the passive muscles from DSRT to TSRT at the respective stretch velocity. The original formulation of the TSRT, DSRT and <em>μ</em> is summarized. Then, a thorough search of literature prior to December 2023 was conducted that returned 25 papers that have used the technique. Eleven of these papers come from the research group of the authors, including 1 reporting on treatment effects. Of the remaining 14 papers, 11 report variations of the methodology with different populations and 3 report on the effects of an intervention. The review discusses how specific modifications to data collection and analysis procedures have either improved the methodology or, in some cases, led to uninterpretable results. The influence of modifications to the data collection and analysis procedures is discussed.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S1388245724002001/pdfft?md5=cad9ad55be67a0ee132ec837cbc6c388&pid=1-s2.0-S1388245724002001-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury 脊髓刺激综合康复方法对脊髓损伤治疗效果的协同影响

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-07-09 DOI: 10.1016/j.clinph.2024.06.015

{"title":"Synergistic implications of combinatorial rehabilitation approaches using spinal stimulation on therapeutic outcomes in spinal cord injury","authors":"","doi":"10.1016/j.clinph.2024.06.015","DOIUrl":"10.1016/j.clinph.2024.06.015","url":null,"abstract":"<div><h3>Objective</h3><p>The objective of this narrative review was to locate and assess recent articles employing a combinatorial approach of transcutaneous spinal cord stimulation or epidural spinal cord stimulation with additional modalities. We sought to provide relevant knowledge of recent literature and advance understanding on outcomes reported, to better equip those working in neurorehabilitation and neuromodulation.</p></div><div><h3>Methods</h3><p>Articles were selected and analyzed based on study approach, stimulation parameters, outcome measures, and presence of neurophysiological data to support findings.</p></div><div><h3>Results</h3><p>This narrative review analyzed 44 recent articles employing a combinatorial approach of transcutaneous spinal cord stimulation or epidural spinal cord stimulation with additional modalities. Our findings showed that limited research exists regarding such combinatorial approaches, particularly when considering modalities beyond activity-based training. There is also limited consistency in neurophysiological and quality of life outcomes.</p></div><div><h3>Conclusion</h3><p>Articles involving transcutaneous spinal cord stimulation or epidural spinal cord stimulation with other modalities are limited in the current body of literature. Authors noted variety in approach, sample size, and use of participant perspective. Opportunities are present to add high quality research to this body of literature.</p></div><div><h3>Significance</h3><p>Transcutaneous spinal cord stimulation and epidural spinal cord stimulation are emerging in research as viable avenues for targeting improvement of function after traumatic spinal cord injury, particularly when combined with activity-based training. This body of literature demonstrates viable areas for growth from both neurophysiological and functional perspectives. Further, exploration of novel combinatorial approaches holds potential to offer enhanced contributions to clinical and neurophysiological rehabilitation and research.</p></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":null,"pages":null},"PeriodicalIF":3.7,"publicationDate":"2024-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141688541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0