Clinical Neurophysiology最新文献_第4页

“The breathing shoulder”: Respiratory synkinesis of the supraspinatus in traumatic brachial plexopathy “呼吸肩”：外伤性臂丛病冈上肌的呼吸联动性

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-26 DOI: 10.1016/j.clinph.2025.2110982

Milan B. Oxspring, Alexander Y. Shin, Nicholas Pulos, Allen T. Bishop, Robert J. Spinner, James B. Meiling

引用次数: 0

Electrophysiological findings in immune checkpoint inhibitor-related neuromuscular events 免疫检查点抑制剂相关神经肌肉事件的电生理结果

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-26 DOI: 10.1016/j.clinph.2025.2110989

E. Lainez , A. Llauradó , M. Gratacòs-Viñola , J.L. Seoane , E. Trallero-Araguás , H. Ariño , M. Roca-Herrera , R. Juntas , N. Raguer

{"title":"Electrophysiological findings in immune checkpoint inhibitor-related neuromuscular events","authors":"E. Lainez , A. Llauradó , M. Gratacòs-Viñola , J.L. Seoane , E. Trallero-Araguás , H. Ariño , M. Roca-Herrera , R. Juntas , N. Raguer","doi":"10.1016/j.clinph.2025.2110989","DOIUrl":"10.1016/j.clinph.2025.2110989","url":null,"abstract":"<div><h3>Introduction</h3><div>Immune checkpoint inhibitors (ICIs) have become key therapies for various malignancies by restoring antitumor immunity. However, they may trigger immune-related adverse events (irAEs), including neurological irAEs (n-irAEs), which, though rare, can be severe. Among these, neuromuscular disorders affecting peripheral nerves, the neuromuscular junction (NMJ), and muscle are the most frequent and carry the highest mortality risk, warranting prompt recognition.</div></div><div><h3>Objective</h3><div>To describe the clinical and electrodiagnostic features of ICI-related neuromuscular disorders in 38 patients.</div></div><div><h3>Methods</h3><div>We retrospectively analyzed patients treated with ICIs referred for electrodiagnostic evaluation due to suspected n-irAEs. Patients were categorized into two phenotypes: (1) ir-Neuropathies (cranial/peripheral neuropathies, radiculopathies) and (2) ir-MG/myositis (myasthenia gravis and/or myositis). Studies included motor/sensory conduction, F-waves, needle EMG, and, when indicated, single-fiber EMG, repetitive stimulation, and evoked potentials.</div></div><div><h3>Results</h3><div>Of 38 patients, 27 (71%) had ir-MG/myositis and 11 (29%) ir-Neuropathies. Myositis with spontaneous activity was the most frequent ir-MG/myositis pattern. In ir-Neuropathies, acute sensory-motor demyelinating polyradiculoneuropathy predominated.</div></div><div><h3>Conclusions</h3><div>Myositis is the most common ir-MG/myositis pattern, while demyelinating polyradiculoneuropathy is typical of ir-Neuropathies. NMJ dysfunction often coexists with myositis and may be missed electrophysiologically.</div></div><div><h3>Significance</h3><div>Electrodiagnosis is essential for early detection and management of ICI-related neuromuscular complications.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110989"},"PeriodicalIF":3.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144922398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peripheral nerve enlargement and hyperechogenicity in patients with X-linked adrenoleukodystrophy using high-resolution ultrasound 高分辨率超声对x连锁肾上腺脑白质营养不良患者周围神经扩大和高回声性的影响

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-26 DOI: 10.1016/j.clinph.2025.2110993

Judith von Hofen-Hohloch, Hannes Roicke, Astrid Unterlauft, Wolfgang Köhler , Petra Baum

{"title":"Peripheral nerve enlargement and hyperechogenicity in patients with X-linked adrenoleukodystrophy using high-resolution ultrasound","authors":"Judith von Hofen-Hohloch, Hannes Roicke, Astrid Unterlauft, Wolfgang Köhler , Petra Baum","doi":"10.1016/j.clinph.2025.2110993","DOIUrl":"10.1016/j.clinph.2025.2110993","url":null,"abstract":"<div><h3>Background</h3><div>Peripheral neuropathy is observed in patients with X-linked adrenoleukodystrophy (x-ALD). High-resolution ultrasound (HRUS) can provide valuable insights into peripheral nerve pathology.</div></div><div><h3>Methods</h3><div>Patients and controls in a 1:3 ratio underwent HRUS of peripheral nerves in the arms and legs. Cross-sectional area (CSA), Ultrasound Pattern Sum Score (UPSS), nerve echogenicity, and nerve homogeneity were measured. Additionally, all patients underwent clinical examinations as well as nerve conduction studies.</div></div><div><h3>Results</h3><div>The study included 51 patients (34 male, 17 female) and 18 age- and sex-matched controls with female patients being significantly older. 43 patients presented with clinical signs of polyneuropathy. 47 patients presented with abnormalities on nerve conductions studies with changes consistent with a mixture of axonal as well as demyelinating patterns. On HRUS, most peripheral nerves exhibited significantly larger mean CSA-values. The UPSS was notably greater in X-ALD patients than in controls (3.7 points vs 1.8 points, p = 0.026). A higher UPSS was significantly associated with a more hyperechoic nerve structure (r = -0.482, p < 0.001).</div></div><div><h3>Conclusion</h3><div>This study reveals significantly enlarged peripheral nerves in X-ALD patients. Moreover, a correlation between enlargement and increasing hyperechogenicity was observed.</div></div><div><h3>Significance</h3><div>This study provides an approach to enhance the understanding of polyneuropathic changes in patients with X-ALD.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110993"},"PeriodicalIF":3.6,"publicationDate":"2025-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144933054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Detection of unilateral 14- and 6-Hz positive bursts after posterior quadrant resection 后象限切除术后单侧14和6hz阳性脉冲的检测

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-25 DOI: 10.1016/j.clinph.2025.2110984

Ricardo Lutzky Saute, Tomásia Oliveira de Holanda Monteiro Frezatti, Bruno Carniatto Marques Garcia, Veriano Alexandre, Frederico Nakane Nakano, Tonicarlo Rodrigues Velasco, Americo Ceiki Sakamoto, João Pereira Leite

引用次数: 0

What is the sensitivity and specificity of intraoperative neuromonitoring for tumors near motor eloquent cortex? 术中神经监测对运动皮层附近肿瘤的敏感性和特异性是什么？

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-21 DOI: 10.1016/j.clinph.2025.2110978

R.N. Holdefer , S.A. Skinner

引用次数: 0

3D-printable stimulation electrodes to improve precision, reproducibility, and reliability of transcranial electric current stimulation 3d打印刺激电极，以提高经颅电流刺激的精度，再现性和可靠性

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-20 DOI: 10.1016/j.clinph.2025.2110981

Silke Kerstens , Luuk van Boekholdt , Jean-Jacques Orban de Xivry , Myles Mc Laughlin

{"title":"3D-printable stimulation electrodes to improve precision, reproducibility, and reliability of transcranial electric current stimulation","authors":"Silke Kerstens , Luuk van Boekholdt , Jean-Jacques Orban de Xivry , Myles Mc Laughlin","doi":"10.1016/j.clinph.2025.2110981","DOIUrl":"10.1016/j.clinph.2025.2110981","url":null,"abstract":"<div><h3>Objective</h3><div>Transcranial electric stimulation (tES) refers to noninvasive neuromodulation techniques that apply a low-amplitude electric current through scalp electrodes to modulate brain activity. Conventional scalp electrodes are made of conductive rubber and are embedded in saline-soaked sponges, held in place using non-conductive rubber straps. Precisely positioning the electrodes at the desired location is challenging, and maintaining their position is equally difficult. In addition, as sponges are prone to drying out during prolonged use, they can compromise the electrode’s conductivity and therefore cause fluctuations in connectivity.</div></div><div><h3>Methods</h3><div>To tackle these limitations of conventional tES electrodes, we designed new 3D-printable gel-filled tES electrodes.</div></div><div><h3>Results</h3><div>We developed electrodes in various sizes ranging in radius from 12 mm to 30 mm to allow a wide variety of options regarding stimulation parameters and electrode montages. By integrating the electrodes into a 10–20-cap, they can be positioned precisely according to the 10–20 coordinate system and the cap holds them in place, even during significant movements.</div></div><div><h3>Conclusions</h3><div>Sharing our 3D-printable electrode designs as open-source can improve precision, reproducibility, and reliability of tES.</div></div><div><h3>Significance</h3><div>In this way, we aim to tackle the reliability and reproducibility issues in the tES field as they provide an accessible and reliable tool to apply tES in humans.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110981"},"PeriodicalIF":3.6,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stronger pre-surgical functional connectivity networks are associated with improved surgical outcome in temporal lobe epilepsy 更强的术前功能连接网络与颞叶癫痫手术效果的改善有关

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-19 DOI: 10.1016/j.clinph.2025.2110980

Brian C. Jung , Victoria Ho , Josh Abata , Sebastian Hanna , Kurt Qing , Doris Deng , Sumeet Vadera , Lilit Mnatsakanyan , Mona Sazgar , David King-Stephens , Daniel W. Shrey , Beth A. Lopour

{"title":"Stronger pre-surgical functional connectivity networks are associated with improved surgical outcome in temporal lobe epilepsy","authors":"Brian C. Jung , Victoria Ho , Josh Abata , Sebastian Hanna , Kurt Qing , Doris Deng , Sumeet Vadera , Lilit Mnatsakanyan , Mona Sazgar , David King-Stephens , Daniel W. Shrey , Beth A. Lopour","doi":"10.1016/j.clinph.2025.2110980","DOIUrl":"10.1016/j.clinph.2025.2110980","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigates the network differences in pre-surgical resting-state EEG between individuals with unilateral temporal lobe epilepsy who become seizure-free and those who continue to have seizures after epilepsy surgery.</div></div><div><h3>Methods</h3><div>We retrospectively identified 15 individuals with unilateral TLE who were seizure-free (SF) after epilepsy surgery and 13 who continued to have seizures post-surgery (nSF). Functional connectivity was measured using cross-correlation techniques on clips of resting-state scalp EEG that were free of any visually apparent epileptiform abnormalities.</div></div><div><h3>Results</h3><div>Stronger pre-surgical functional connectivity was associated with favorable post-surgical outcomes. The SF group demonstrated significantly higher connectivity strength, particularly in cross-hemispheric and intra-hemispheric networks involving the ictal hemisphere (P = 0.02). Functional connectivity strength predicted post-surgical seizure freedom with 75 % accuracy (AUC = 0.77). Notably, individuals with the strongest connectivity were all seizure-free, despite heterogeneity in clinical characteristics or imaging findings. Connectivity strength did not correlate with age, disease duration, hippocampal sclerosis, or bilateral epileptiform abnormalities.</div></div><div><h3>Conclusion</h3><div>Functional connectivity networks derived from visually normal EEG can provide non-invasive, non-redundant information beyond traditional assessments to predict post-surgical outcomes.</div></div><div><h3>Significance</h3><div>This study further supports the concept that epilepsy is a disorder of neural networks.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"179 ","pages":"Article 2110980"},"PeriodicalIF":3.6,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144889019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cortical hyperexcitability in corticobasal syndrome as revealed by giant somatosensory evoked potentials 巨大体感诱发电位揭示皮质基底综合征的皮质高兴奋性

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-18 DOI: 10.1016/j.clinph.2025.2110977

Maya Tojima , Masanori Sawamura , Atsushi Shima , Etsuro Nakanishi , Nobukatsu Sawamoto , Ryosuke Takahashi , Akio Ikeda , Riki Matsumoto

{"title":"Cortical hyperexcitability in corticobasal syndrome as revealed by giant somatosensory evoked potentials","authors":"Maya Tojima , Masanori Sawamura , Atsushi Shima , Etsuro Nakanishi , Nobukatsu Sawamoto , Ryosuke Takahashi , Akio Ikeda , Riki Matsumoto","doi":"10.1016/j.clinph.2025.2110977","DOIUrl":"10.1016/j.clinph.2025.2110977","url":null,"abstract":"<div><h3>Objective</h3><div>Corticobasal syndrome (CBS) is characterized by asymmetric symptoms, including myoclonus. Few studies have reported the observation of giant somatosensory evoked potentials (SEPs) in CBS patients. We aimed to clarify the origin and characteristics of myoclonus by examining the relationships among clinical symptoms and electrophysiological and brain imaging findings.</div></div><div><h3>Methods</h3><div>We conducted a cross-sectional study of 23 patients with CBS who underwent SEPs at Kyoto University Hospital from 2008 to 2022. We compared SEPs, cortical reflex (C-reflex), and cerebral perfusion in the precentral and postcentral gyri and thalamus between the symptom-dominant and non-dominant hemispheres.</div></div><div><h3>Results</h3><div>Giant SEPs were observed in 17 of 23 (74 %) patients, and C-reflexes were present in 3 of 13 (23 %) patients. Cerebral perfusion decreased significantly on the symptom dominant contralateral hemisphere.</div></div><div><h3>Conclusions</h3><div>The high frequency of giant SEPs than previously reported in CBS demonstrated that at least part of their myoclonus has a cortical origin, warranting further investigation into the underlying mechanisms.</div></div><div><h3>Significance</h3><div>The high prevalence of giant SEPs in CBS suggests a cortical contribution to their myoclonus, providing electrophysiological evidence to help better understanding and clinical assessment of the disorder.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"178 ","pages":"Article 2110977"},"PeriodicalIF":3.6,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144865052","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bridging Chinese and Western medicine through clinical neurophysiological methods 通过临床神经生理学方法衔接中西医结合

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-18 DOI: 10.1016/j.clinph.2025.2110967

Zhen Ni

引用次数: 0

From mechanisms to meaningful outcomes: Translational challenges in memory-oriented transcranial electrical stimulation research. 从机制到有意义的结果：面向记忆的经颅电刺激研究的转化挑战。

IF 3.6 3区医学

Clinical Neurophysiology Pub Date : 2025-08-15 DOI: 10.1016/j.clinph.2025.2110970

Saša R Filipović, Jovana Bjekić

引用次数: 0