Clinical Neurophysiology最新文献_第4页

Reply to "intraoperativecorticobulbar motor evoked potentials and blink reflex during skull base surgery: Significance of anesthetic Regime". 对 "颅底手术中术中皮质束巴运动诱发电位和眨眼反射：麻醉制度的意义"。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 Epub Date: 2024-10-25 DOI: 10.1016/j.clinph.2024.10.009

Jiajia Liu, Xing Fan, Lirui Yang, Xiaorong Tao, Yanwen Jin, Ke Li, Jun Yang, Hui Qiao

引用次数: 0

The part and the whole: how single nodes contribute to large-scale phase-locking in functional EEG networks. 部分与整体：单个节点如何促进功能性脑电图网络中的大规模相位锁定。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 Epub Date: 2024-09-19 DOI: 10.1016/j.clinph.2024.09.008

Anaïs Espinoso, Marc G Leguia, Christian Rummel, Kaspar Schindler, Ralph G Andrzejak

{"title":"The part and the whole: how single nodes contribute to large-scale phase-locking in functional EEG networks.","authors":"Anaïs Espinoso, Marc G Leguia, Christian Rummel, Kaspar Schindler, Ralph G Andrzejak","doi":"10.1016/j.clinph.2024.09.008","DOIUrl":"10.1016/j.clinph.2024.09.008","url":null,"abstract":"<p><strong>Objective: </strong>The application of signal analysis techniques to electroencephalographic (EEG) recordings from epilepsy patients shows that epilepsy involves not only altered neuronal synchronization but also the reorganization of functional EEG networks. This study aims to assess the large-scale phase-locking of such functional networks and how individual network nodes contribute to this collective dynamics.</p><p><strong>Methods: </strong>We analyze the EEG recorded before, during and after seizures from sixteen patients with pharmacoresistant focal-onset epilepsy. The data is filtered to low (4-30 Hz) and high (80-150 Hz) frequencies. We define the multivariate phase-locking measure and the univariate phase-locking contribution measure. Surrogate signals are used to estimate baseline results expected under the null hypothesis that the EEG is a correlated linear stochastic process.</p><p><strong>Results: </strong>On average, nodes from inside and outside the seizure onset zone (SOZ) increase and decrease, respectively, the large-scale phase-locking. This difference becomes most evident in a joint analysis of low and high frequencies.</p><p><strong>Conclusions: </strong>Nodes inside and outside the SOZ play opposite roles for the large-scale phase-locking in functional EEG network in epilepsy patients.</p><p><strong>Significance: </strong>The application of the phase-locking contribution measure to EEG recordings from epilepsy patients can potentially help in localizing the SOZ.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":"178-192"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of abnormal cortical inhibition and clinical outcomes in patients at clinical high risk for psychosis

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 DOI: 10.1016/j.clinph.2024.11.015

Guanfu Wu , Tianyuan Zhu , Chunyan Ma , Lihua Xu , Zhenying Qian , Gai Kong , Huiru Cui , Tianhong Zhang , Jijun Wang , Yingying Tang

{"title":"Association of abnormal cortical inhibition and clinical outcomes in patients at clinical high risk for psychosis","authors":"Guanfu Wu , Tianyuan Zhu , Chunyan Ma , Lihua Xu , Zhenying Qian , Gai Kong , Huiru Cui , Tianhong Zhang , Jijun Wang , Yingying Tang","doi":"10.1016/j.clinph.2024.11.015","DOIUrl":"10.1016/j.clinph.2024.11.015","url":null,"abstract":"<div><h3>Objective</h3><div>Cortical inhibition (CI) can be in-vivo measured using transcranial magnetic stimulation (TMS), and patients with schizophrenia had abnormal CI. However, whether the abnormal CI occur early in patients with clinical high risk for psychosis (CHR) or could predict their clinical outcomes remains less known.</div></div><div><h3>Methods</h3><div>We measured short-interval cortical inhibition (SICI), cortical silent period (CSP), and intra-cortical facilitation (ICF) over the motor cortex and neurocognitive performances in 55 CHR, 35 first-episode schizophrenia (FES), and 35 healthy controls (HC). We divided CHR patients into CHR converters (CHR-C) and CHR non-converters (CHR-NC) according to their clinical outcomes within the two-year follow-up.</div></div><div><h3>Results</h3><div>CSP was longer in CHR-C (P = 0.033) and FES (P = 0.047) than in HC, while CSP was comparable between CHR-NC and HC. In CHR, CSP was negatively related to their performances in symbol coding and maze tasks. There was no significant between-group difference for either SICI or ICF.</div></div><div><h3>Conclusions</h3><div>Our findings suggested GABA<sub>B</sub>-mediated CSP was prolonged in CHR, who later converted into schizophrenia, and was associated with poor neurocognitive functions.</div></div><div><h3>Significance</h3><div>CSP is prolonged before the onset of psychosis, particularly in CHR-C patients, suggesting that CSP could be a potential biomarker for predicting transition to schizophrenia.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 65-73"},"PeriodicalIF":3.7,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The seizure onset zone: More than just the "onset" zone. 癫痫发作区：不仅仅是 "发作 "区

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-12-01 Epub Date: 2024-10-18 DOI: 10.1016/j.clinph.2024.10.002

Katherine A Zarroli, Ramon Edmundo D Bautista

引用次数: 0

Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-28 DOI: 10.1016/j.clinph.2024.11.014

Brenda Y. Angulo-Ruiz, Elena I. Rodríguez-Martínez, Vanesa Muñoz, Carlos M. Gómez

{"title":"Unveiling the hidden electroencephalographical rhythms during development: Aperiodic and Periodic activity in healthy subjects","authors":"Brenda Y. Angulo-Ruiz, Elena I. Rodríguez-Martínez, Vanesa Muñoz, Carlos M. Gómez","doi":"10.1016/j.clinph.2024.11.014","DOIUrl":"10.1016/j.clinph.2024.11.014","url":null,"abstract":"<div><h3>Objective</h3><div>The study analyzes power spectral density (PSD) components, aperiodic (AP) and periodic (P) activity, in resting-state EEG of 240 healthy subjects from 6 to 29 years old, divided into 4 groups.</div></div><div><h3>Methods</h3><div>We calculate AP and P components using the (<em>Fitting Oscillations and One-Over-f (FOOOF))</em> plugging in EEGLAB. All PSD components were calculated from 1-45 Hz. Topography analysis, Spearman correlations, and regression analysis with age were computed for all components.</div></div><div><h3>Results</h3><div>AP and P activity show different topography across frequencies and age groups. Age-related decreases in AP exponent and offset parameters lead to reduced power, while P power decreases (1–6 Hz) and increases (10–15 Hz) with age.</div></div><div><h3>Conclusions</h3><div>We support the distinction between the AP and P components of the PSD and its possible functional changes with age. AP power is dominant in the configuration of the canonical EEG rhythms topography, although P contribution to topography is embedded in the canonical EEG topography. Some EEG canonical characteristics are similar to those of the P component, as topographies of EEG rhythms (embedded) and increases in oscillatory frequency with age.</div></div><div><h3>Significance</h3><div>We support that spectral power parameterization improves the interpretation and neurophysiological and functional accuracy of brain processes.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 53-64"},"PeriodicalIF":3.7,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142759430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-26 DOI: 10.1016/j.clinph.2024.11.012

Fioravante Capone, Francesco Motolese, Alessandro Cruciani, Mariagrazia Rossi, Gabriella Musumeci, Davide Norata, Massimo Marano, Fabio Pilato, Vincenzo Di Lazzaro

{"title":"The effects of transcutaneous auricular vagus nerve stimulation (taVNS) on cholinergic neural networks in humans: A neurophysiological study","authors":"Fioravante Capone, Francesco Motolese, Alessandro Cruciani, Mariagrazia Rossi, Gabriella Musumeci, Davide Norata, Massimo Marano, Fabio Pilato, Vincenzo Di Lazzaro","doi":"10.1016/j.clinph.2024.11.012","DOIUrl":"10.1016/j.clinph.2024.11.012","url":null,"abstract":"<div><h3>Objective</h3><div>The mechanisms of actions of transcutaneous auricular vagus nerve stimulation (taVNS) are still unclear, however the activity of the cholinergic system seems to be critical for the induction of VNS-mediated plasticity. Transcranial Magnetic Stimulation (TMS) is a well-suited, non-invasive tool to investigate cortical microcircuits involving different neurotransmitters. Herein, we evaluated the effect of taVNS on short-latency afferent inhibition (SAI), a TMS paradigm specifically measuring cholinergic neurotransmission.</div></div><div><h3>Methods</h3><div>Fifteen healthy subjects participated in this randomized placebo-controlled double-blind study. Each subject underwent two different sessions of 1-hour exposure to taVNS (real and sham) separated by a minimum of 48 h. Real taVNS was administered at left external acoustic meatus, while sham stimulation was performed at left ear lobe. We evaluated SAI bilaterally over the motor cortex before and after exposure to taVNS.</div></div><div><h3>Results</h3><div>No side effects were reported by any of the participants.</div><div>Statistical analysis did not show any significant effect of taVNS on SAI.</div></div><div><h3>Conclusions</h3><div>Our study demonstrated that cholinergic circuits explored by SAI are different from circuits engaged by taVNS.</div></div><div><h3>Significance</h3><div>Since the influence of VNS on cholinergic neurotransmission has been exhaustively demonstrated in animal models, further studies are mandatory to understand the actual impact of VNS on cholinergic circuits in humans.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 47-52"},"PeriodicalIF":3.7,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142743861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-24 DOI: 10.1016/j.clinph.2024.11.013

Ke Liao, Laura E Martin, Sodiq Fakorede, William M Brooks, Jeffrey M Burns, Hannes Devos

{"title":"Machine learning based on event-related oscillations of working memory differentiates between preclinical Alzheimer's disease and normal aging.","authors":"Ke Liao, Laura E Martin, Sodiq Fakorede, William M Brooks, Jeffrey M Burns, Hannes Devos","doi":"10.1016/j.clinph.2024.11.013","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.11.013","url":null,"abstract":"<p><strong>Objective: </strong>To apply machine learning approaches on EEG event-related oscillations (ERO) to discriminate preclinical Alzheimer's disease (AD) from age- and sex-matched controls.</p><p><strong>Methods: </strong>Twenty-two cognitively normal preclinical AD participants with elevated amyloid and 21 cognitively normal controls without elevated amyloid completed n-back working memory tasks (n = 0, 1, 2). The absolute and relative power of ERO was extracted using the discrete wavelet transform in the delta, theta, alpha, and beta bands. Four machine learning methods were employed, and classification performance was assessed using three metrics.</p><p><strong>Results: </strong>The low-frequency bands produced higher discriminative performances compared to high-frequency bands. The 2-back task yielded the best classification capability among the three tasks. The highest area under the curve value (0.86) was achieved in the 2-back delta band nontarget condition data. The highest accuracy (80.47%) was obtained in the 2-back delta and theta bands nontarget data. The highest F1 score (0.82) was in the 2-back theta band nontarget data. The support vector machine achieved the highest performance among tested classifiers.</p><p><strong>Conclusion: </strong>This study demonstrates the promise of using machine learning on EEG ERO from working memory tasks to detect preclinical AD.</p><p><strong>Significance: </strong>EEG ERO may reveal pathophysiological differences in the earliest stage of AD when no cognitive impairments are apparent.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"170 ","pages":"1-13"},"PeriodicalIF":3.7,"publicationDate":"2024-11-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repetitive muscle silent periods in acute post-anoxic brain injury: A novel phenotype of negative myoclonus 缺氧后急性脑损伤中的重复性肌肉沉默期：阴性肌阵挛的新表型

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.010

Saeideh Salehizadeh , Suhailah Hakami , Ramesh Shrestha , Neel Fotedar

{"title":"Repetitive muscle silent periods in acute post-anoxic brain injury: A novel phenotype of negative myoclonus","authors":"Saeideh Salehizadeh , Suhailah Hakami , Ramesh Shrestha , Neel Fotedar","doi":"10.1016/j.clinph.2024.11.010","DOIUrl":"10.1016/j.clinph.2024.11.010","url":null,"abstract":"<div><h3>Objective</h3><div>To report a novel phenotype of negative myoclonus in acute post-anoxic brain injury (PABI).</div></div><div><h3>Methods</h3><div>We performed a retrospective analysis of 18-channel video-EEG and surface-EMG (sEMG) recordings of three patients with PABI. sEMG electrodes were placed on the neck, bulbar and arm muscles.</div></div><div><h3>Results</h3><div>All three patients had whole body tonic posturing with intermittent brief relaxation<strong>.</strong> In patients #1 and #2, a generalized EEG burst-suppression was present. Repetitive silent periods (SPs) were noted in the sEMG channels, time-locked to EEG bursts. The bursts preceded the SPs by 135 ms and 124 ms, respectively. The average SP duration was 910 ms and 852 ms in patients #1 and 2, respectively. Patient #3 had a generalized background suppression pattern and average SP duration of 272.5 ms. The SP recruitment pattern in patient #1 was rostro-caudal whereas patient #3 had a variable recruitment pattern.</div></div><div><h3>Conclusion</h3><div>Acute post-anoxic negative myoclonus can be detected in comatose patients with sEMG electrodes. The muscle SPs produce intermittent relaxation of the tonic posturing. The putative generator can be cortical or reticular, similar to Lance-Adams syndrome.</div></div><div><h3>Significance</h3><div>We describe a novel phenotype of negative myoclonus in acute PABI. We also describe the EEG and sEMG characteristics and the localization of the putative generator.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 4-10"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Muscle ultrasound aids diagnosis in amyotrophic lateral sclerosis. 肌肉超声有助于肌萎缩性脊髓侧索硬化症的诊断。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.008

Andrew Hannaford, Nathan Pavey, Parvathi Menon, Mehdi A J van den Bos, Matthew C Kiernan, Neil Simon, Steve Vucic

{"title":"Muscle ultrasound aids diagnosis in amyotrophic lateral sclerosis.","authors":"Andrew Hannaford, Nathan Pavey, Parvathi Menon, Mehdi A J van den Bos, Matthew C Kiernan, Neil Simon, Steve Vucic","doi":"10.1016/j.clinph.2024.11.008","DOIUrl":"https://doi.org/10.1016/j.clinph.2024.11.008","url":null,"abstract":"<p><strong>Objective: </strong>There is a need for improved diagnostic tools in Amyotrophic Lateral Sclerosis (ALS). Our objective was to assess muscle ultrasound as a diagnostic tool in patients with ALS and determine a simplified screening protocol to aid implementation in clinical practice.</p><p><strong>Methods: </strong>Ultrasound of bulbar and limb muscles was prospectively performed on all patients referred to a single centre with suspected ALS. Clinical measures of disease severity and upper motor neuron impairment were also recorded. Receiver operating characteristic (ROC) curves were calculated to assess the diagnostic utility of muscle ultrasound.</p><p><strong>Results: </strong>94 patients initially suspected of ALS were recruited to this observational cohort study. Forty-four were subsequently diagnosed as ALS and 50 as disease mimics. ALS patients demonstrated a higher frequency and more generalised distribution of fasciculations compared to mimics. A simplified 5 muscle screening protocol exhibited an AUC of 0.94 (95 %CI 0.89-0.99) in discriminating ALS from mimics. The presence of ≥ 3 fasciculating muscles detected using this screening protocol was 89 % sensitive and 88 % specific for the diagnosis of ALS.</p><p><strong>Conclusions: </strong>Muscle ultrasound, screening as few as 5 muscles, has diagnostic utility in ALS.</p><p><strong>Significance: </strong>Muscle ultrasound enhances clinical diagnosis in ALS.</p>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":" ","pages":""},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142708889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia DLPFC上的双侧tDCS可增强气压感受器反射灵敏度并抑制与血压相关的低痛感

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2024-11-22 DOI: 10.1016/j.clinph.2024.11.011

Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso

{"title":"Bilateral tDCS over the DLPFC enhances baroreceptor reflex sensitivity and inhibits blood pressure-related hypoalgesia","authors":"Casandra I. Montoro , Pilar Ruiz-Medina , Stefan Duschek , Nicolás Gutiérrez-Palma , Gustavo A. Reyes del Paso","doi":"10.1016/j.clinph.2024.11.011","DOIUrl":"10.1016/j.clinph.2024.11.011","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the impact of transcranial direct stimulation (tDCS) on pain perception, baroreflex sensitivity (BRS), and blood pressure (BP)-related hypoalgesia.</div></div><div><h3>Method</h3><div>Fifty-eight healthy participants were randomized to receive 1) bi-hemispheric tDCS over the dorsolateral prefrontal cortex (DLPFC) at 2 mA for 20 min, or 2) non-stimulation (Sham). Pain measures (threshold, tolerance, intensity and unpleasantness), emotional state (anxiety and mood), continuous BP, and electrocardiogram (ECG) data were recorded before, during, and after stimulation.</div></div><div><h3>Results</h3><div>tDCS stimulation was followed by increases in BRS, pain intensity and unpleasantness. Anxiety decreased in the Sham group, but not in the tDCS group. Positive correlations between BP and pain threshold and tolerance before stimulation were observed. These remained during stimulation in the Sham group, but not in the tDCS group. Moreover, negative associations between BRS and BP only persisted in the Sham group.</div></div><div><h3>Discussion</h3><div>The results suggest that bilateral tDCS over the DLPFC enhances BRS and modulates pain perception and BP-related mechanisms. tDCS increases pain perception by inhibiting BP-related hypoalgesia and preventing habituation of anxiety.</div></div><div><h3>Significance</h3><div>Low BRS is a powerful prognostic factor of cardiovascular disease, such that its increase via tDCS may be a new therapeutic strategy for cardiovascular health promotion.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"169 ","pages":"Pages 11-22"},"PeriodicalIF":3.7,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142699729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0