Clinical Neurophysiology最新文献

{"title":"Diagnostic utility of clinical neurophysiology in Wilson’s disease with hyperkinetic movements","authors":"Alban Gravier ,&nbsp;Mickael Alexandre Obadia ,&nbsp;Jean-Luc Thibault ,&nbsp;Christine Delmaire ,&nbsp;Aurélia Poujois ,&nbsp;Nathalie Kubis","doi":"10.1016/j.clinph.2025.2111471","DOIUrl":"10.1016/j.clinph.2025.2111471","url":null,"abstract":"<div><h3>Objective</h3><div>Movement disorders (MD) are frequent in Wilson’s disease (WD). Surface electromyography (sEMG) with accelerometry is commonly used to analyze hyperkinetic MD, as clinical examination may be insufficiently sensitive. We present here the first neurophysiological description of MD in WD patients to: (1) assess the sensitivity of neurophysiology relative to clinical evaluation; (2) correlate MD diagnosed by neurophysiology with the biological and radiological data of patients.</div></div><div><h3>Methods</h3><div>WD patients with hyperkinetic MD not fully characterized by clinical examination alone were included from December 2012 to December 2021. Clinical, biological, brain MRI and neurophysiology evaluations were conducted at inclusion and during follow-up.</div></div><div><h3>Results</h3><div>We included 12 WD patients (3.9 % of the total cohort, and 11 % of the patients with neurological complications). During follow-up, neurophysiological evaluation identified 10 patients as having either isolated or combined tremors (seven postural, six resting, four orthostatic, four functional, two kinetic and one dystonic tremors), and five myoclonus. Four cases of pseudo orthostatic tremors, five of myoclonus and two functional tremors were not detected clinically. Action tremor on sEMG was the only MD significantly associated with a mild-to-moderate midbrain FLAIR hypersignal.</div></div><div><h3>Conclusion</h3><div>Postural and resting tremors were the most frequent MD, whereas myoclonus was the most frequent MD that had remained clinically uncharacterized and diagnosed at neurophysiological evaluation.</div></div><div><h3>Significance</h3><div>This study emphasizes the undeniable added value of neurophysiological evaluation in these patients.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111471"},"PeriodicalIF":3.6,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Repetitive wide-band cortical power in benign adult familial myoclonus epilepsy","authors":"Haruo Yamanaka ,&nbsp;Katsuya Kobayashi ,&nbsp;Takefumi Hitomi ,&nbsp;Maya Tojima ,&nbsp;Masao Matsuhashi ,&nbsp;Kiyohide Usami ,&nbsp;Ryosuke Takahashi ,&nbsp;Akio Ikeda","doi":"10.1016/j.clinph.2025.2111486","DOIUrl":"10.1016/j.clinph.2025.2111486","url":null,"abstract":"<div><h3>Background</h3><div>Cortical tremor (CT), a rhythmic variant of cortical myoclonus (CM), is the hallmark of benign adult familial myoclonus epilepsy (BAFME), though the underlying mechanism of rhythmicity remains unproven. This study aimed to reveal the cortical rhythmic activity of CT using induced activity analysis for somatosensory evoked potentials (SEP).</div></div><div><h3>Methods</h3><div>We investigated 46 SEP datasets from 23 patients (11 with BAFME, 12 with other CM) and 35 SEPs from 18 healthy controls. SEPs were recorded by 1.1-Hz stimuli at a sampling rate of 10,000 Hz. A short-time Fourier transform was applied to each SEP epoch, and the power spectrums were averaged. We set an analysis window of 0–150 ms and a frequency range of 0–1,000 Hz for time–frequency representation and compared the induced power changes between groups.</div></div><div><h3>Results</h3><div>Stimulus-induced power changes over a wide-band (0–1000 Hz) were conspicuously prominent in BAFME patients compared to both CM and controls. These activities presented repetitive and alternating increases and decreases in power and its total number of induced activities were the highest in age 40s and declined with aging.</div></div><div><h3>Conclusions</h3><div>We demonstrated rhythmic cortical activity in BAFME patients, which may reflect the underlying pathophysiology of CT.</div></div><div><h3>Significance</h3><div>Detecting the induced activity of a single somatosensory stimulus may offer novel insights into the pathophysiology of BAFME.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111486"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corticospinal excitability as distinctive neurophysiological feature of acquired glycine receptor antibody syndrome","authors":"Pietro Antenucci ,&nbsp;Lorenzo Rocchi ,&nbsp;Emanuela Maria Raho ,&nbsp;Michele Laudisi ,&nbsp;Mariachiara Sensi ,&nbsp;Maura Pugliatti ,&nbsp;Anna Latorre ,&nbsp;Jay Guido Capone","doi":"10.1016/j.clinph.2025.2111479","DOIUrl":"10.1016/j.clinph.2025.2111479","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111479"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of memory neurofeedback system utilizing intracranial electroencephalogram of the hippocampus","authors":"Ako Matsuhashi ,&nbsp;Seijiro Shimada ,&nbsp;Naoto Kunii ,&nbsp;Takeshi Matsuo ,&nbsp;Anna Takeda ,&nbsp;Toshiya Aono ,&nbsp;Shigeta Fujitani ,&nbsp;Keisuke Nagata ,&nbsp;Makoto Sato ,&nbsp;Yohei Ishishita ,&nbsp;Kenji Ibayashi ,&nbsp;Keisuke Ohtani ,&nbsp;Yoshiyuki Onuki ,&nbsp;Kensuke Kawai ,&nbsp;Nobuhito Saito","doi":"10.1016/j.clinph.2025.2111490","DOIUrl":"10.1016/j.clinph.2025.2111490","url":null,"abstract":"<div><h3>Objective</h3><div>Patients with temporal lobe epilepsy (TLE) suffer from epileptic seizures and memory decline. While focal resection eliminates seizures in 60–70% of patients, surgery carries the risk of further compromising memory. We hypothesized that hippocampal neurofeedback (NF) will induce targeted brain activity associated with memory function.</div></div><div><h3>Methods</h3><div>Patients with intracranial electrodes implanted in bilateral hippocampi performed a memory NF task, developed specifically for this project. The NF task involved real-time analysis of hippocampal activity using the electrode in the less-affected hippocampus while conducting a memory task. Changes in theta activity and task performance were assessed.</div></div><div><h3>Results</h3><div>The NF task was conducted in seven TLE patients. In five patients, theta activity increased significantly in the targeted hippocampus (Mann-Kendall test; p &lt; 0.05). Mixed linear model analysis across all sessions revealed a significant increase in theta activity in the targeted hippocampus (p = 0.0032), with no significant change contralaterally (p = 0.19). Three additional TLE patients underwent random NF to assess if theta activity was induced merely by the encoding process, but none of them showed significant changes in theta activity.</div></div><div><h3>Conclusion</h3><div>Memory NF task effectively induced targeted hippocampal activity in TLE patients.</div></div><div><h3>Significance</h3><div>Hippocampal NF may enhance memory function in TLE patients prior to focal resection.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111490"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the accuracy of motor evoked potential determination: The overlooked role of surface electrode montage","authors":"Marco Antonio Cavalcanti Garcia ,&nbsp;Anaelli Aparecida Nogueira-Campos","doi":"10.1016/j.clinph.2025.2111483","DOIUrl":"10.1016/j.clinph.2025.2111483","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111483"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788252","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artifactual signal detection using intraoperative electrocorticographic devices during functional brain mapping of brain tumors","authors":"William O. Tatum ,&nbsp;Adrian Safa ,&nbsp;Filippo Colella ,&nbsp;Erik H. Middlebrooks ,&nbsp;Anteneh M. Feyissa ,&nbsp;Aafreen Khan ,&nbsp;David Sabsevitz ,&nbsp;Alicia Kissinger-Knox ,&nbsp;Phillip Gauthier ,&nbsp;Dawn Radford ,&nbsp;Anahita Jafari ,&nbsp;Marco Failla Mulone ,&nbsp;Sanjeet Grewal ,&nbsp;Rich Byrne ,&nbsp;Kaisorn Chaichana ,&nbsp;Alfredo Quinones-Hinojosa ,&nbsp;Brin Freund","doi":"10.1016/j.clinph.2025.2111489","DOIUrl":"10.1016/j.clinph.2025.2111489","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the signal detection performance of a circular grid versus a strip electrode during intraoperative electrocorticography (iECoG) for Functional Brain Mapping (FBM).</div></div><div><h3>Methods</h3><div>We performed a single center retrospective evaluation of signal detection by recording intraoperative ECoG comparing two intraoperative recording devices and techniques during awake craniotomy for FBM. A circular grid and linear strip evaluated stimulation artifact, afterdischarges (ADs), and epileptiform activity.</div></div><div><h3>Results</h3><div>142 patients underwent awake craniotomy, and 26 (18.3 %) had reoperations with repeat iECoG performed during their subsequent procedure. A total of 71 patients underwent iECoG using circular grids and 71 with linear strip electrodes. Max and min Signal amplitudes were higher with the circular grid (p &lt; 0.01). The minimum (2.3 vs. 2.8 mA) and maximum (4.9 vs. 6.3 mA) currents required to evoke visible stimulation artifact were lower with the circular grid (p &lt; 0.01), suggesting increased sensitivity to stimulation-related signals. Physiological signals represented by ADs were detected in 59.2 % of circular-grid patients vs 40.8 % of strip-electrode patients (Fisher’s exact p = 0.044). When adjusting for stimulation trials in a Negative Binomial model with an offset, AD rates per stimulation were 2.5 × higher with circular grids (rate ratio 2.51; 95 % CI 1.61–3.91; p &lt; 0.0001). Total stimulation counts were 2,786 (circular) and 2,209 (strip). Notably, the circular grid also involved more electrodes (5.06 vs. 0.95,<!--> <!-->p &lt; 0.001).</div></div><div><h3>Conclusions</h3><div>High-density circular grids enhance intraoperative detection of artifacts and ADs with lower stimulus currents.</div></div><div><h3>Significance</h3><div>The high-density circular grid offered more interpretable contacts and higher sensitivity.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111489"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145832922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cerebellar repetitive transcranial magnetic stimulation attenuates essential tremor by modulating visuomotor network connectivity","authors":"Xue Shi ,&nbsp;Runyang He ,&nbsp;Lin Zhu ,&nbsp;Nan Yan ,&nbsp;Shaoxia Fan ,&nbsp;Zian Pei ,&nbsp;Xiaolin Su ,&nbsp;Fali Li ,&nbsp;Yumei Liu ,&nbsp;Ge Dang ,&nbsp;Shuhan Fan ,&nbsp;Peng Xu ,&nbsp;Dezhong Yao ,&nbsp;Robert Chen ,&nbsp;Yi Guo","doi":"10.1016/j.clinph.2025.2111472","DOIUrl":"10.1016/j.clinph.2025.2111472","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the neurophysiological mechanisms underlying cerebellar repetitive transcranial magnetic stimulation (rTMS) in essential tremor (ET) using source-level electroencephalography (EEG) phase-locking value analysis.</div></div><div><h3>Methods</h3><div>EEG recordings and clinical assessments of ET patients (n = 20) before and after 4-week bilateral cerebellar rTMS were studied and evaluated for correlations. Brain source activities were reconstructed using standardized low-resolution brain electromagnetic tomography (LORETA). Functional connectivity and local network metrics in the alpha band (8–13 Hz) were compared with those of healthy controls (n = 20).</div></div><div><h3>Results</h3><div>ET patients had lower nodal efficiency in visual areas and reduced inter-regional occipital connectivity than controls. Local network metrics in the left superior occipital gyrus, left cuneus, and right fusiform gyrus negatively correlated with tremor severity and significantly improved with rTMS. Connectivity changes between the left inferior occipital gyrus (IOG) and superior parietal gyrus (SPG) and the right SPG and midcingulate cortex (MCC), strongly correlated with improvements in activities of daily living. Performance-related connectivity changes involved the left IOG-SPG, right SPG-MCC, and left middle occipital gyrus to the supplementary motor area.</div></div><div><h3>Conclusions</h3><div>Cerebellar rTMS may alleviate ET by reorganizing functional connectivity within the visuomotor network.</div></div><div><h3>Significance</h3><div>Our findings provide preliminary mechanistic insights and potential biomarkers for ET treatment, pending validation in future sham-controlled studies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111472"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145788253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detecting emotion in individuals with disorders of consciousness: a pilot study of heart rate deceleration on affective auditory stimuli","authors":"Hugo Ardaillon ,&nbsp;Anne Dubois ,&nbsp;Kate-Mary Ndocko ,&nbsp;Jérôme Etienne ,&nbsp;Catherine Tallon-Baudry ,&nbsp;Jacques Luauté","doi":"10.1016/j.clinph.2025.2111469","DOIUrl":"10.1016/j.clinph.2025.2111469","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate heart rate deceleration on affective auditory stimulations as an objective marker of purposeful affective behaviour, as used in the diagnosis of minimally conscious state (MCS) in brain-injured individuals with disorders of consciousness (DoC), awake but unable to communicate.</div></div><div><h3>Methods</h3><div>We recorded the heart rate of participants (14 healthy controls and 10 brain injured individuals, conscious or with DoC) on repeated exposure to a random sequence of three emotional sounds of neutral, positive, and negative valence, in an unconditioned manner (experiment 1) or in a trace-conditioning procedure (experiment 2), with successful trace-conditioning assumed to indicate consciousness.</div></div><div><h3>Results</h3><div>In experiment 1, heart rate deceleration after aversive acoustic stimulus was significantly higher in healthy subjects at the group level from the second to the seventh inter-beat interval, with limited sensitivity at the individual level. In experiment 2, there was no evidence of trace-conditioned learning in healthy subjects, precluding any extrapolation to brain-injured individuals.</div></div><div><h3>Conclusions</h3><div>Heart rate deceleration after aversive acoustic stimulus was significant in passive hearing but not in a trace-conditioning paradigm and was of limited sensitivity at the individual level.</div></div><div><h3>Significance</h3><div>Heart rate deceleration may constitute an objective marker of purposeful affective behaviour triggered by emotional sounds. The question of whether this response is a reflex or a marker of conscious access needs further study.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111469"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neural signatures of central auditory aging under sensory and cognitive loads","authors":"Yifat Yaar-Soffer ,&nbsp;Brilliant Brilliant ,&nbsp;Chava Muchnik ,&nbsp;Andrej Kral ,&nbsp;Yael Henkin","doi":"10.1016/j.clinph.2025.2111465","DOIUrl":"10.1016/j.clinph.2025.2111465","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the neural mechanisms underlying auditory processing in older adults (OAs) under conditions of sensory-perceptual (S-P) and auditory-cognitive (A-C) loads.</div></div><div><h3>Methods</h3><div>Electroencephalography was recorded in 20 OAs (mean age = 69.6 ± 5.2 years) with age-appropriate hearing and preserved cognition, and 20 younger adults (YAs) (mean age = 24.9 ± 1.8 years). Participants performed tasks under S-P load (quiet vs. noise), A-C load (simple vs. demanding task), and combined load. Analyses included event-related potentials and time-frequency representations.</div></div><div><h3>Results</h3><div>OAs showed delayed early (N1) and late (P3) cortical responses and slower reaction times (RTs) compared to YAs. Increased alpha-band desynchronization emerged as an age-related biomarker, reflecting OAs’ reduced ability to inhibit irrelevant information. Distinct load-specific processing strategies appeared: S-P load was associated with delayed neural responses across cortical stages, longer RTs, and delta- and theta-band activity. A-C load was associated with prolonged late (P3) cortical activity, slower RTs, and broader neural recruitment across all frequency bands. Under combined load, OAs showed P3 latency prolongation, revealing vulnerability to the dual challenge of noise suppression and cognitive demand.</div></div><div><h3>Conclusion</h3><div>Integrated time- and frequency-domain electroencephalography analyses exposed distinct listening strategies in OAs, characterized by load-specific neural signatures.</div></div><div><h3>Significance</h3><div>Improved understanding of auditory processing strategies in OAs will advance targeted auditory rehabilitation.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111465"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145735500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cortical connectivity reorganization Induced by tDCS and Robotic-Assisted gait training in individuals with spinal cord injury","authors":"Daniel Boari Coelho ,&nbsp;Artur Cesar Aquino dos Santos ,&nbsp;Felipe Fregni ,&nbsp;Linamara Rizzo Battistella","doi":"10.1016/j.clinph.2025.2111498","DOIUrl":"10.1016/j.clinph.2025.2111498","url":null,"abstract":"","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"183 ","pages":"Article 2111498"},"PeriodicalIF":3.6,"publicationDate":"2026-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145837690","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}