Clinical Neurophysiology最新文献_第4页

Neuromagnetic evidence of the foot primary somatosensory area in the frontal cortex 足部额叶皮层初级体感区的神经磁证据

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-24 DOI: 10.1016/j.clinph.2025.2110767

Makoto Ishida, Haruka Katayama, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato

{"title":"Neuromagnetic evidence of the foot primary somatosensory area in the frontal cortex","authors":"Makoto Ishida, Haruka Katayama, Yosuke Kakisaka, Kazutaka Jin, Nobukazu Nakasato","doi":"10.1016/j.clinph.2025.2110767","DOIUrl":"10.1016/j.clinph.2025.2110767","url":null,"abstract":"<div><h3>Objective</h3><div>The location of the foot primary somatosensory area (SI) is puzzling in contrast to the parietal localization of the hand SI. Electrical cortical stimulation studies have revealed the foot somatosensory function in the paracentral lobule anterior and posterior to the central sulcus (CS). A recent study of intraoperative somatosensory evoked potentials (SEPs) using posterior tibial nerve (PTN) stimulation revealed frontal localization of the foot SI. However, most previous studies using scalp SEPs and somatosensory evoked magnetic fields (SEFs) for PTN found that the initial cortical components (P40/P40m) were localized in the parietal lobe. This study evaluated the location of the equivalent current dipole (ECD) for PTN-SEFs on individual magnetic resonance imaging (MRI) in normal adults.</div></div><div><h3>Methods</h3><div>PTN-SEFs were recorded in 16 hemispheres of 8 normal subjects. The P40m ECD was superimposed on individual anatomical MRIs.</div></div><div><h3>Result</h3><div>Mean ECD location of the P40m was 3.1 ± 4.2 mm (mean ± standard error) anterior and 6.9 ± 4.2 mm inferior to the inferior end of the CS.</div></div><div><h3>Conclusions</h3><div>Our findings suggest frontal localization of the human foot SI.</div></div><div><h3>Significance</h3><div>The functional anatomy of the human foot SI cannot be established by extrapolation of the hand SI.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110767"},"PeriodicalIF":3.7,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144297876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cerebral circuits involved in preferential hand posture representation for action 大脑回路涉及动作的优先手部姿势表征

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-23 DOI: 10.1016/j.clinph.2025.2110757

V. Piombino , M. D’Alonzo , F. Castro , G. Pellegrino , G. Musumeci , V. Di Lazzaro , G. Di Pino

{"title":"Cerebral circuits involved in preferential hand posture representation for action","authors":"V. Piombino , M. D’Alonzo , F. Castro , G. Pellegrino , G. Musumeci , V. Di Lazzaro , G. Di Pino","doi":"10.1016/j.clinph.2025.2110757","DOIUrl":"10.1016/j.clinph.2025.2110757","url":null,"abstract":"<div><h3>Objective</h3><div>The thumb-down/fingers-up (standard) posture was shown to be the configuration in which the hand is preferentially represented by the brain. This supra-modal representation results in improved sensorimotor performances. This study aims at identifying the cortical circuit responsible for this advantage.</div></div><div><h3>Methods</h3><div>Different TMS coil orientations (antero-posterior, latero-medial, postero-anterior) − activating different cortical circuits- have been used to test cortico-spinal and cortico-cortical connections in different postures. Additionally, pair-pulse TMS protocols were used to explore inhibitory and facilitatory mechanisms within the primary motor cortex (M1) that might contribute to the observed postural advantage.</div></div><div><h3>Results</h3><div>A significant corticospinal excitability difference in nMEPs between standard and inverse posture was observed with antero-posterior TMS (p = 0.003), activating cortico-cortical connections from premotor cortex (PM) and with postero-anterior TMS (p = 0.042), favoring local cortical connections. Latero-medial stimulation, activating direct corticospinal connections, did not show a preference. A MEPs analysis further revealed a significant effect exclusively for antero-posterior stimulation (p < 0.003). Intracortical facilitation and inhibition were unaffected by hand postures.</div></div><div><h3>Conclusions</h3><div>The postural advantage of the thumb-down/fingers-up hand configuration is associated with a neural circuit involving PM cortex projecting to M1, activated by antero-posterior and postero-anterior TMS.</div></div><div><h3>Significance</h3><div>The corticospinal evoked activity to different TMS protocols gave cues on the neural basis of body representation and favored posture.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110757"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144195223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring neural variability, movement variability and motor learning in healthy adults and people with stroke 探索健康成人和中风患者的神经变异性、运动变异性和运动学习

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-23 DOI: 10.1016/j.clinph.2025.2110759

Erin M. Lyons , Mitchell R. Goldsworthy , Brenton Hordacre

{"title":"Exploring neural variability, movement variability and motor learning in healthy adults and people with stroke","authors":"Erin M. Lyons , Mitchell R. Goldsworthy , Brenton Hordacre","doi":"10.1016/j.clinph.2025.2110759","DOIUrl":"10.1016/j.clinph.2025.2110759","url":null,"abstract":"<div><h3>Objective</h3><div>Investigate the association between neural variability, movement variability and motor learning in people with chronic stroke and healthy adults.</div></div><div><h3>Methods</h3><div>Thirty participants (17 healthy, 13 stroke) underwent assessments involving transcranial magnetic stimulation and a novel pinch-grip task. Neural variability was approximated as trial-to-trial amplitude variability of motor evoked potentials recorded at the hand following transcranial magnetic stimulation to the motor cortex. Movement variability was assessed as trial-to-trial deviations when performing a pinch grip task. Motor learning was assessed on a pinch grip task to trace an unknown shape, with reward scores provided to performance.</div></div><div><h3>Results</h3><div>Healthy adults performed better on the motor learning task (t<sub>(28)</sub> = -1.70, <em>p</em> = 0.05). Greater movement variability was associated with better motor learning in people with stroke (r = -0.68, <em>p</em> = 0.015), but not healthy adults. Neural variability was not found to predict movement variability or motor learning in healthy adults or people with stroke (all <em>p</em> > 0.05).</div></div><div><h3>Conclusion</h3><div>Increased movement variability supports better motor learning in people with chronic stroke, possibly due to increased exploration of successful movement solutions.</div></div><div><h3>Significance</h3><div>Movement variability appears worthy of investigation to improve motor learning and recovery from stroke.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110759"},"PeriodicalIF":3.7,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144139237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neurophysiological findings of the trigeminal and facial nerves in Parry Romberg syndrome Parry Romberg综合征三叉神经和面神经的神经生理学研究

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-22 DOI: 10.1016/j.clinph.2025.2110758

Daniel San-Juan , Fernando Cisnero-Flores , Gerardo Quiñones-Pesqueira , Jorge Burgos-Centeno , Daniel Arturo Martínez-Piña , Evelin Zulema Camacho-Castillo , Miguel Angel Morales-Morales , Claudia Gutiérrez Gómez

引用次数: 0

Reliability of short interval cortical inhibition in children with attention deficit hyperactivity disorder 儿童注意缺陷多动障碍的短间隔皮质抑制的可靠性

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-19 DOI: 10.1016/j.clinph.2025.2110750

Donald L. Gilbert , David A. Huddleston , Karlee Y. Migneault , Deana Crocetti , Paul S. Horn , Steve W. Wu , Stewart H. Mostofsky

{"title":"Reliability of short interval cortical inhibition in children with attention deficit hyperactivity disorder","authors":"Donald L. Gilbert , David A. Huddleston , Karlee Y. Migneault , Deana Crocetti , Paul S. Horn , Steve W. Wu , Stewart H. Mostofsky","doi":"10.1016/j.clinph.2025.2110750","DOIUrl":"10.1016/j.clinph.2025.2110750","url":null,"abstract":"<div><h3>Objective</h3><div>Utility of biomarkers depends on test–retest consistency. Reduced Short Interval Cortical Inhibition (SICI) has emerged as a consistent finding in children with Attention Deficit Hyperactivity Disorder (ADHD); however, test–retest has not been established for children with ADHD. This is particularly crucial given that Transcranial Magnetic Stimulation (TMS) motor evoked potential (MEP)-based measures have high intra-subject variability and susceptibility to state-effects on motor cortex excitability. Addressing this, the objective of this study was to estimate test–retest reliability of paired-pulse SICI and of Intracortical Facilitation (ICF) in children, including those with ADHD and typically developing (TD) controls.</div></div><div><h3>Methods</h3><div>Sixty-four 8-to-12-year-old children (28 female; 35 ADHD; 29 TD) were recruited at two sites and SICI and ICF measured across two visits separated by 21 days. Intraclass correlations (ICCs) were calculated.</div></div><div><h3>Results</h3><div>Good reliability for SICI (ICC > 0.75), but only moderate for ICF (ICC > 0.50), was found among ADHD children, after accounting for test-pulse MEP amplitudes (>0.25 mV) and outliers.</div></div><div><h3>Conclusions</h3><div>These findings support the potential for SICI as a biomarker of ADHD in school-aged children.</div></div><div><h3>Significance</h3><div>This research addresses a critical gap in clinical neurophysiology, as estimating the reliability of SICI is needed to utilize it in interventional or longitudinal studies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110750"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144123853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expert consensus on the combined investigation of polyneuropathies with electrodiagnostic tests and neuromuscular ultrasound 专家对多神经病变联合电诊断试验和神经肌肉超声检查的共识

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-19 DOI: 10.1016/j.clinph.2025.2110749

Luciana Pelosi , Zsuzsanna Arányi , Daniele Coraci , Alexander Grimm , Ingrid Herraets , Lisa D. Hobson-Webb , Antonios Kerasnoudis , Ruth Leadbetter , Simon Podnar , Neil Simon , Johan Telleman , Nens van Alfen , Leo Visser , Francis O. Walker , Natalie Winter , Eppie M. Yiu , Craig Zaidman , Michael S. Cartwright

{"title":"Expert consensus on the combined investigation of polyneuropathies with electrodiagnostic tests and neuromuscular ultrasound","authors":"Luciana Pelosi , Zsuzsanna Arányi , Daniele Coraci , Alexander Grimm , Ingrid Herraets , Lisa D. Hobson-Webb , Antonios Kerasnoudis , Ruth Leadbetter , Simon Podnar , Neil Simon , Johan Telleman , Nens van Alfen , Leo Visser , Francis O. Walker , Natalie Winter , Eppie M. Yiu , Craig Zaidman , Michael S. Cartwright","doi":"10.1016/j.clinph.2025.2110749","DOIUrl":"10.1016/j.clinph.2025.2110749","url":null,"abstract":"<div><div>Consensus was sought from 17 nominated global expert leaders to provide guidance on the combined use of neuromuscular ultrasound (NMUS) and electrodiagnostic tests (EDX) in the investigation of peripheral neuropathy (PN) in clinical practice.</div><div>Consensus was based on an initial systematic review of the literature by the experts themselves, followed by three anonymised surveys, using the Delphi method. No consensus was defined as < 60 % rating frequency.</div><div>The panel agreed that NMUS should be used if EDX cannot differentiate an axonal from a demyelinating process or an acquired from a hereditary process, and in the investigation of vasculitic neuropathy; NMUS of the brachial plexus should be used in Guillain-Barre’ syndrome if EDX is negative; when NMUS is used, at least two nerves of the upper limbs should be scanned; NMUS should be used for screening or repeat testing for carpal tunnel syndrome in children with mucopolysaccharidoses.</div><div>Areas of disagreement exposed gaps in current knowledge and informed the direction of future research, which should aim to identify situations in which NMUS can stand alone as a diagnostic test, particularly for screening or repeat testing and especially in vulnerable individuals and paediatric populations.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110749"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144125205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reduction of sleep-like perilesional slow waves and clinical evolution after stroke: A TMS-EEG study 脑卒中后睡眠样病变周围慢波减少和临床演变：一项TMS-EEG研究

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-19 DOI: 10.1016/j.clinph.2025.2110746

S. Sarasso , S. D’Ambrosio , S. Russo , L. Bernardelli , G. Hassan , A. Comanducci , P. De Giampaulis , L.A. Dalla Vecchia , J. Lanzone , M. Massimini

{"title":"Reduction of sleep-like perilesional slow waves and clinical evolution after stroke: A TMS-EEG study","authors":"S. Sarasso , S. D’Ambrosio , S. Russo , L. Bernardelli , G. Hassan , A. Comanducci , P. De Giampaulis , L.A. Dalla Vecchia , J. Lanzone , M. Massimini","doi":"10.1016/j.clinph.2025.2110746","DOIUrl":"10.1016/j.clinph.2025.2110746","url":null,"abstract":"<div><h3>Objective</h3><div>Recent studies indicate that brain injuries often lead to the occurrence of sleep-like slow waves in perilesional cortical areas. These slow waves may disrupt local cortico-cortical interactions and contribute to behavioral impairments but are, in principle, reversible. This study employs Transcranial Magnetic Stimulation (TMS) combined with Electroencephalography (EEG) to monitor changes in perilesional slow waves and local cortical interactions examining their relation to changes in stroke severity.</div></div><div><h3>Methods</h3><div>Twelve patients with post-acute/chronic unilateral ischemic cortical stroke participated in a longitudinal study with two assessment points. Each assessment included a neurological evaluation using the National Institutes of Health Stroke Scale (NIHSS) and TMS-EEG recordings targeting perilesional cortical areas. Neurophysiological parameters, such as slow wave amplitude (SWa), high-frequency power (HFp) suppression, and the Perturbational Complexity Index-state transition (PCIst), were extracted from the perilesional EEG responses to TMS to quantify local sleep-like slow waves andcortical interactions.</div></div><div><h3>Results</h3><div>We observed a perilesional reduction in sleep-like slow waves and a restoration of local cortical interactions. Notably, these changes significantly correlated with patients’ clinical evolution as assessed by the NIHSS score.</div></div><div><h3>Conclusions</h3><div>These findings highlight the potential of TMS-EEG as an objective tool for tracking neurological evolution post-stroke.</div></div><div><h3>Significance</h3><div>Targeting sleep-like cortical dynamics may be relevant for devising post-stroke rehabilitation strategies.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110746"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Motor cortex excitability states in chronic stroke patients probed by EEG-TMS 脑电-经颅磁刺激对慢性脑卒中患者运动皮层兴奋状态的影响

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-19 DOI: 10.1016/j.clinph.2025.2110747

Arianna Brancaccio , Davide Tabarelli , David Baur , Johanna Roesch , Wala Mahmoud , Ulf Ziemann , Paolo Belardinelli

{"title":"Motor cortex excitability states in chronic stroke patients probed by EEG-TMS","authors":"Arianna Brancaccio , Davide Tabarelli , David Baur , Johanna Roesch , Wala Mahmoud , Ulf Ziemann , Paolo Belardinelli","doi":"10.1016/j.clinph.2025.2110747","DOIUrl":"10.1016/j.clinph.2025.2110747","url":null,"abstract":"<div><h3>Objective</h3><div>In healthy subjects, the trough vs. no-trough phases of the sensorimotor µ-rhythm correspond to high- vs. low-excitability states of the motor cortex (M1). We tested this excitability differentiation in the ipsilesional (iM1) and contralesional M1 (cM1) of chronic stroke patients.</div></div><div><h3>Methods</h3><div>19 chronic stroke patients received single-pulse transcranial magnetic stimulation (TMS), separately over the iM1 and cM1, during EEG recordings. High and low M1 excitability states were defined by binning a post-hoc estimate of the µ-phase at TMS delivery. TMS-evoked EEG potentials (TEPs) and time–frequency responses were characterized for excitability states and hemispheres. The motor function of the affected arm was tested by the Fugl-Meyer Assessment Upper Extremity (FMA-UE.</div></div><div><h3>Results</h3><div>In cM1, TMS at the high- vs. low-excitability state resulted in larger TEP amplitudes and increased post-pulse power in the beta band. In iM1, these modulations were not significant except for post-pulse beta power. This retained excitability differentiation significantly correlated with FMA-UE.</div></div><div><h3>Conclusions</h3><div>The degree of excitability differentiation in iM1 depending on phase of the sensorimotor µ-rhythm correlates with individual affected upper extremity motor function.</div></div><div><h3>Significance</h3><div>The degree of excitability differentiation in iM1 might serve as a new independent marker of motor recovery.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110747"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144115828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infraslow scalp electroencephalogram is closely linked to transient neurological events in Moyamoya disease 下低频头皮脑电图与烟雾病中一过性神经事件密切相关。

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-19 DOI: 10.1016/j.clinph.2025.2110748

Kozue Hayashi , Kiyohide Usami , Masaya Togo , Yukihiro Yamao , Takeshi Funaki , Takefumi Hitomi , Takayuki Kikuchi , Masao Matsuhashi , Kazumichi Yoshida , Yoshiki Arakawa , Ryosuke Takahashi , Susumu Miyamoto , Akio Ikeda

{"title":"Infraslow scalp electroencephalogram is closely linked to transient neurological events in Moyamoya disease","authors":"Kozue Hayashi , Kiyohide Usami , Masaya Togo , Yukihiro Yamao , Takeshi Funaki , Takefumi Hitomi , Takayuki Kikuchi , Masao Matsuhashi , Kazumichi Yoshida , Yoshiki Arakawa , Ryosuke Takahashi , Susumu Miyamoto , Akio Ikeda","doi":"10.1016/j.clinph.2025.2110748","DOIUrl":"10.1016/j.clinph.2025.2110748","url":null,"abstract":"<div><h3>Background</h3><div>Transient neurological events (TNEs) commonly occur following direct revascularization for moyamoya disease (MMD). Although changes in the cerebral blood flow (CBF) may be linked to TNEs, the underlying mechanism remains unclear. Herein, we investigated the relationship between TNEs and EEG to elucidate the underlying mechanisms and pursue the clinical utility of EEG as a TNE biomarker.</div></div><div><h3>Methods</h3><div>Twenty-six hemispheres in 22 patients with MMD aged ≥15 years who underwent revascularization were analyzed. Scalp electroencephalography (EEG) and single-photon emission computed tomography (SPECT) performed within 7 days postoperatively were analyzed using the clinical information.</div></div><div><h3>Results</h3><div>Sixteen of 26 hemispheres developed TNEs, of which 12 demonstrated an increased frequency of delta waves (> 0.5, < 4 Hz) on postoperative EEG (<em>P</em> = 0.0002), which was located in an area consistent with each symptom. Infraslow activity (ISA, < 0.33 Hz) was observed in all 4 hemispheres on the day of TNE development. More frequent occurrence of delta wave on postoperative EEG preceded onset in 2 hemispheres. CBF did not differ between the patients with and without TNEs.</div></div><div><h3>Conclusions</h3><div>ISA may be associated with the pathophysiology of TNEs. Delta waves can be used as clinical biomarkers to predict TNEs.</div></div><div><h3>Significance</h3><div>Slow waves on scalp EEG have the potential can predict and elucidate TNEs.</div><div>Non-standard Abbreviations and Acronyms.</div><div>TNEs, transient neurological events; MMD, Moyamoya disease; ISA, infraslow activity; SD, spreading depolarization; TC, time constant.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"176 ","pages":"Article 2110748"},"PeriodicalIF":3.7,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144246856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Seizure and electroencephalographic characteristics in anti-LGI1 encephalitis 抗lgi1脑炎的癫痫发作和脑电图特征

IF 3.7 3区医学

Clinical Neurophysiology Pub Date : 2025-05-17 DOI: 10.1016/j.clinph.2025.2110753

Chun-Hong Shen , Wen-Jie Ming , Yin-Xi Zhang , Meng-Ting Cai , Bin-Qing Du , Ye Du , Yong-Feng Xu , Zhong-Jin Wang , Yi Guo , Yao Ding , Sha Xu , Yin Hu , Xue-Mei Zhang , Shuang Wang , Mei-Ping Ding

{"title":"Seizure and electroencephalographic characteristics in anti-LGI1 encephalitis","authors":"Chun-Hong Shen , Wen-Jie Ming , Yin-Xi Zhang , Meng-Ting Cai , Bin-Qing Du , Ye Du , Yong-Feng Xu , Zhong-Jin Wang , Yi Guo , Yao Ding , Sha Xu , Yin Hu , Xue-Mei Zhang , Shuang Wang , Mei-Ping Ding","doi":"10.1016/j.clinph.2025.2110753","DOIUrl":"10.1016/j.clinph.2025.2110753","url":null,"abstract":"<div><h3>Objective</h3><div>To delineate seizure and electroencephalographic (EEG) characteristics in a cohort of patients with anti-leucine-rich glioma-inactivated 1 (LGI1) encephalitis.</div></div><div><h3>Methods</h3><div>Sixty-six newly diagnosed anti-LGI1 encephalitis patients with seizures were consecutively recruited. EEG data was obtainable for 63 patients, including 24-hour video EEG (VEEG) for 35 participants. Demographics, seizure characteristics, EEG findings, and general clinical data were reviewed.</div></div><div><h3>Results</h3><div>Among 66 patients, facial brachial dystonic seizures (FBDS), focal non-FBDS seizures, and secondarily generalized tonic-clonic seizures (sGTCS) occurred in 27.3 %, 59.1 %, and 57.6 %, respectively. Piloerection was observed in 27.3 %, and daily focal seizures were reported in 74.2 %. Sex-related analysis indicated females exhibited younger onset age with higher prevalence of focal non-FBDS seizures, piloerection, and daily seizures, whereas males had more sGTCS and cerebrospinal fluid abnormalities (p < 0.05). Interictal EEG revealed excessive beta activity (EBA) in 40.0 %, interictal epileptiform discharges in 22.2 %, and rhythmic delta activity in 12.7 %. Quantitative analysis provided confirmation of EBA. VEEG captured clinical events in 48.6 % and subclinical seizures (SCS) in 20.0 %.</div></div><div><h3>Conclusions</h3><div>We highlight seizure characteristics in anti-LGI1 encephalitis, particularly piloerection, daily focal seizures, and sex-related differences. Beyond previously reported SCS, EBA appears to be a frequent EEG pattern.</div></div><div><h3>Significance</h3><div>These findings may facilitate the recognition of anti-LGI1 encephalitis.</div></div>","PeriodicalId":10671,"journal":{"name":"Clinical Neurophysiology","volume":"175 ","pages":"Article 2110753"},"PeriodicalIF":3.7,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144146943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0