Attenuated theta-band activity and cross-frequency coupling in schizophrenia during affective response inhibition.

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-10-15 DOI:10.1016/j.clinph.2025.2111386

Jacob D Kraft, Takakuni Suzuki, Margo W Menkes, Carolyn M Andrews, Melvin G McInnis, Patricia J Deldin, Ivy F Tso

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引用次数: 0

Abstract

Objective: Schizophrenia (SZ) is marked by impaired cognitive control; however, the underlying neural mechanisms remain unclear. This study examined theta-band (4-7 Hz) neural oscillatory activity and cross-frequency coupling with gamma (30-50 Hz) in an affective cognitive control paradigm in SZ in comparison with healthy controls (HC) and those with bipolar disorder (BD).

Methods: Thirty-two participants with SZ, 67 with BD, and 48 HC completed an affective Go/No-Go Task with emotional face stimuli during electroencephalography recording. Time-frequency decomposition quantified theta-band power and intertrial phase consistency (ITPC) over midline fronto-central areas. Theta-gamma phase-amplitude coupling (PAC; Kullback-Leibler Modulation Index) was indexed within the midline frontal area and cross-regionally between midline frontal theta and bilateral parietal gamma.

Results: Participants with SZ displayed decreased midline frontal theta power, ITPC, and local midline frontal theta-gamma PAC compared to HC, with BD falling in between SZ and HC groups across all these measures. Theta power, ITPC, and theta-gamma PAC were correlated with behavioral performance, particularly in the SZ group.

Conclusion: Findings show abnormalities across the amplitude, phase consistency, and cross-frequency coordination aspects of theta-related activity when individuals with SZ engage in affective cognitive control.

Significance: This study supports the assertion that SZ is associated with abnormal theta-related neural activity.

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情感反应抑制期间精神分裂症的θ波段活性减弱和交叉频率耦合。

目的：精神分裂症（SZ）以认知控制功能受损为特征；然而，潜在的神经机制尚不清楚。本研究考察了情感认知控制范式下SZ与健康对照（HC）和双相情感障碍（BD）患者的theta波段（4- 7hz）神经振荡活动和与gamma （30- 50hz）的交叉频率耦合。方法：在脑电图记录中，32例SZ、67例BD和48例HC患者完成了情绪性面部刺激的情感性Go/No-Go任务。时频分解量化了中线前中央区域的波段功率和试验间相位一致性。theta -gamma相位振幅耦合（PAC； Kullback-Leibler调制指数）在额叶中线区域内以及额叶中线θ和双侧顶叶伽马之间的跨区域被索引。结果：与HC组相比，SZ组的参与者表现出较低的中线额波功率、ITPC和局部中线额波theta-gamma PAC，在所有这些测量中，BD介于SZ组和HC组之间。Theta功率、ITPC和Theta -gamma PAC与行为表现相关，尤其是在SZ组。结论：研究结果显示，当SZ患者参与情感认知控制时，theta相关活动的振幅、相位一致性和交叉频率协调方面都存在异常。意义：本研究支持SZ与异常的θ相关神经活动相关的论断。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.