Paired associative electroacupuncture and transcranial magnetic stimulation induced plasticity in human primary motor cortex.

IF 3.6 3区医学 Q1 CLINICAL NEUROLOGY

Clinical Neurophysiology Pub Date : 2025-08-13 DOI:10.1016/j.clinph.2025.2110969

Meiqi Lai, Jiaxin Xiao, Jie Zhan, Wenting Li, Jianpeng Huang, Sheng Li, Nenggui Xu, Jianhua Liu

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引用次数: 0

Abstract

Objective: Paired-associative stimulation (PAS) integrates transcranial magnetic stimulation (TMS) with peripheral nerve stimulation to modulate the primary motor cortex (M1) in a non-invasive manner. Numerous studies highlight its impact on M1 excitability; however, the interplay between electroacupuncture (EA) and TMS on M1 excitability remains largely unexplored. So, we designed a new PAS protocol (namely EA-PAS, an integration of EA and TMS at M1) to investigate whether the EA-PAS has the same effects as the original PAS.

Methods: To confirm the physiological effects of different EA-PAS protocols, we recorded the baseline MEP amplitude in 20 healthy subjects and conducted assessments at 7-time points after the EA-PAS intervention.

Results: EA-PAS₂₅ increased M1 excitability, while EA-PAS₁₀ decreased it, similar to the original PAS, with effects localized to the target muscle. No significant changes were observed with EA or TMS alone. MEPs rose at ISIs of 17 ms, 25 ms, and 35 ms, but not at 50 ms. ISIs of 10 ms and 14 ms resulted in decreased MEPs.

Conclusions: This study confirmed that EA-PAS can modulate the excitability of the human M1 and identified new temporal windows, indicating potential prospects for neurological rehabilitation.

Significance: This provides a preliminary clinical basis for the future application of EA-PAS in neurological rehabilitation.

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配对联合电针和经颅磁刺激诱导人初级运动皮层可塑性。

目的：配对联想刺激（PAS）结合经颅磁刺激（TMS）和周围神经刺激，以无创方式调节初级运动皮层（M1）。大量研究强调其对M1兴奋性的影响；然而，电针（EA）和经颅磁刺激（TMS）对M1兴奋性的相互作用在很大程度上仍未被探索。因此，我们设计了一种新的PAS方案（即EA-PAS， EA和TMS在M1处的集成）来研究EA-PAS是否具有与原始PAS相同的效果。方法：为了确认不同EA-PAS方案的生理效果，我们记录了20名健康受试者的基线MEP振幅，并在EA-PAS干预后的7个时间点进行了评估。结果：EA-PAS25增加了M1的兴奋性，而EA-PAS10降低了M1的兴奋性，与原PAS相似，且作用局限于靶肌。单独使用EA或TMS均未观察到明显变化。在17 ms、25 ms和35 ms时，MEPs升高，但在50 ms时没有升高。10 ms和14 ms的ISIs导致MEPs下降。结论：本研究证实了EA-PAS可以调节人类M1的兴奋性，并发现了新的时间窗口，显示了神经康复的潜在前景。意义：为将来EA-PAS在神经康复中的应用提供初步的临床依据。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Neurophysiology 医学-临床神经学

CiteScore

8.70

自引率

6.40%

发文量

932

审稿时长

59 days

期刊介绍： As of January 1999, The journal Electroencephalography and Clinical Neurophysiology, and its two sections Electromyography and Motor Control and Evoked Potentials have amalgamated to become this journal - Clinical Neurophysiology. Clinical Neurophysiology is the official journal of the International Federation of Clinical Neurophysiology, the Brazilian Society of Clinical Neurophysiology, the Czech Society of Clinical Neurophysiology, the Italian Clinical Neurophysiology Society and the International Society of Intraoperative Neurophysiology.The journal is dedicated to fostering research and disseminating information on all aspects of both normal and abnormal functioning of the nervous system. The key aim of the publication is to disseminate scholarly reports on the pathophysiology underlying diseases of the central and peripheral nervous system of human patients. Clinical trials that use neurophysiological measures to document change are encouraged, as are manuscripts reporting data on integrated neuroimaging of central nervous function including, but not limited to, functional MRI, MEG, EEG, PET and other neuroimaging modalities.