Clinical Physiology and Functional Imaging最新文献

{"title":"Mueller manoeuvre increases the mitral-to-aortic velocity–time integral ratio, a mitral regurgitant index, in patients with dilated cardiomyopathy","authors":"Juha Virolainen,&nbsp;Markku Ventilä,&nbsp;Markku Kupari","doi":"10.1111/cpf.70090","DOIUrl":"10.1111/cpf.70090","url":null,"abstract":"<p>A reduction of intrathoracic pressure during the Mueller manoeuvre (MM) has been shown to decrease left ventricular (LV) forward stroke volume in patients with systolic heart failure. To assess the underlying mechanisms, we analyzed MM-induced changes in LV inflow and outflow dynamics in 13 healthy individuals (mean age 42 y, 8 men) and in 13 patients with dilated cardiomyopathy (DCM) (mean age 44 y, 8 men) having LV ejection fraction &lt;40% without mitral regurgitation. The subjects performed MM with a target of −30 mmHg pressure for &gt;10 s. Doppler echocardiography was used to record systolic and diastolic flow velocities at the aortic and mitral valve annulus, respectively, during quiet respiration and the MM. The respective flow velocity-time integrals (VTI) were measured. Compared with control subjects, patients with DCM had a larger MM-induced decrease in the aortic VTI (−4.2 ± 0.3 vs. −1.6 ± 0.5 cm; <i>p</i> &lt; 0.001) combined with a tendency to a smaller decrease in the mitral VTI (−1.4 ± 0.5 vs. –2.2 ± 0.3 cm; <i>p</i> = 0.070). The mitral-to-aortic VTI ratio, an indirect mitral regurgitant index, increased in DCM from 0.78 ± 0.04 to 1.03 ± 0.08 (<i>p</i> = 0.006) but decreased in the control group from 0.70 ± 0.03 to 0.61 ± 0.03 (<i>p</i> = 0.025). The group x MM interaction was statistically highly significant (<i>F</i> = 16.8, <i>p</i> &lt; 0.001). We conclude that, in DCM-related heart failure, a reduction of intrathoracic pressure during the MM increases the mitral-to-aortic VTI ratio suggesting appearance of functional mitral regurgitation.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148864131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardiac volumes, function, and arterial stiffness five years after severe preeclampsia: A comparison with sedentary and active controls","authors":"Camilla Edvinsson,&nbsp;Katarina Steding-Ehrenborg,&nbsp;Ashwin Venkateshvaran,&nbsp;Lena Erlandsson,&nbsp;Stefan R. Hansson,&nbsp;Erik Hedström","doi":"10.1111/cpf.70088","DOIUrl":"10.1111/cpf.70088","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Preeclampsia is a pregnancy disorder characterized by hypertension and multiorgan failure related to endothelial damage. It is associated with increased risk of cardiovascular disease later in life, but pathophysiological mechanisms are unclear, and strategies to identify women at risk are missing. The aim was to investigate cardiovascular impact 5 years after severe preeclampsia, compared to normotensive pregnancies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The study was powered to detect approximately 5% difference between groups by cardiac magnetic resonance (CMR). Ten women experiencing severe preeclampsia, and 20 women with normotensive pregnancies were included: 10 lifestyle-matched and 10 physically active. Brachial blood pressure, echocardiography and CMR were performed 4–7 years after pregnancy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There was no difference in systolic or diastolic blood pressure, and all women were normotensive (103 vs. 106 vs. 108 mmHg, <i>p</i> = 0.67; and 66 vs. 66 vs. 64 mmHg, <i>p</i> = 0.78). Indexed left ventricular volumes were larger for active controls than for women with prior preeclampsia (98 vs. 84 mL/m², <i>p</i> = 0.004; and 41 vs. 32 mL/m², <i>p</i> = 0.01). Left ventricular mass, cardiac function and pulse wave velocity did not differ. No participant fulfilled the criteria for diastolic dysfunction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The difference in left ventricular volumes is most likely related to a physiological adaptation to exercise. The lack of persistent hypertension may be the factor explaining the absence of clinically significant differences between groups using routine investigations for cardiovascular structure and function, despite severe preeclampsia. Structured follow-up is essential to enable early diagnosis of hypertension after preeclampsia, as well as supporting an active and potentially protective lifestyle.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13501347/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to “Pulmonary Volumes and Signs of Chronic Airflow Limitation in Quantitative Computed Tomography”","authors":"","doi":"10.1111/cpf.70087","DOIUrl":"https://doi.org/10.1111/cpf.70087","url":null,"abstract":"<p>Bäcklin, E., Gonon, A., Sköld, M., Smedby, Ö., Breznik, E. &amp; Janerot-Sjoberg, B. (2024) Pulmonary volumes and signs of chronic airflow limitation in quantitative computed tomography. Clinical Physiology and Functional Imaging, 44, 340–348. https://doi.org/10.1111/cpf.12880</p><p>An error was identified in the description of the CT reconstruction parameters in the original 2024 manuscript, “Pulmonary Volumes and Signs of Chronic Airflow Limitation in Quantitative Computed Tomography.” The manuscript incorrectly reported a slice thickness of 0.6 mm and a B31f reconstruction kernel. The correct parameters were a slice thickness of 0.75 mm and an I50f medium-sharp lung reconstruction kernel. This error is limited to the reporting of the reconstruction parameters and does not affect the study analyses, results, interpretation, or conclusions.</p><p>We apologize for this error.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70087","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148784623","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic and prognostic value of left atrioventricular coupling index post revascularization in acute coronary syndrome: A two-dimensional echocardiographic study","authors":"Ashraf M. Anwar,&nbsp;Abdelrahman Almalki,&nbsp;Wesam Daus,&nbsp;Abdullah Aladnani,&nbsp;Rakan Aun,&nbsp;Basel Alzahrani,&nbsp;Maryam A. M. Ali","doi":"10.1111/cpf.70086","DOIUrl":"10.1111/cpf.70086","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The calculation of the left atrioventricular coupling index (LACI) by the ratio between left atrial (LA) and left ventricular (LV) end-diastolic volumes reflects the close interaction between LA and LV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Aim of the Study</h3>\u0000 \u0000 <p>The study aimed to assess LACI using echocardiography before and after percutaneous coronary intervention (PCI) compared with LV ejection fraction (LV-EF) in acute coronary syndrome (ACS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Subjects and Methods</h3>\u0000 \u0000 <p>This retrospective cohort analysis included 193 ACS patients (65.1 ± 12.5 years, 71.6% males), who underwent PCI. Both LACI and LV-EF were calculated before and after PCI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>At presentation, 156 (80.8%) patients had LV-EF reduction; mild in 61 (39.1%), moderate in 77 (49.3%) and severe in 18 (11.5%). Using LACI &lt; 25% as the cutoff value for normal, 40 (20.7%) patients had impaired LACI. Out of the 153 patients with normal LACI, 127 (83%) had reduced LV-EF. Patients were classified into three groups: I: 51 (26.4%) with STEMI, II: 82 (42.5%) with NSTEMI and III: 60 (31.1%) with unstable angina. Baseline LV-EF and LACI did not show significant differences between the three groups. Over a 12.8 ± 8.2 month follow-up post PCI, LV-EF improved in 68 (43.6%) out of 156 patients becoming normal in 28 (17.9%), mildly reduced in 65 (41.7%), moderately reduced in 55 (35.2%) and severely reduced in 8 (5.1%). Post PCI, LACI normalized in 19 (47.5%) out of 40 patients with impaired baseline LACI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Assessing LACI in ACS provided a better understanding of LA and LV dynamics and its reduction following PCI indicates a better prognosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 5","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the effect of mavacamten on left ventricular function in obstructive hypertrophic cardiomyopathy using myocardial work","authors":"Linlin Wan,&nbsp;Xixi Chen,&nbsp;Ziwei Huang,&nbsp;Junyi Ren,&nbsp;WenJuan Lu,&nbsp;Hong Ran","doi":"10.1111/cpf.70084","DOIUrl":"10.1111/cpf.70084","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effect of 12-week Mavacamten on left ventricular function in obstructive hypertrophic cardiomyopathy (oHCM) using myocardial work analysis, and explore its role in myocardial energy metabolism.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-five oHCM patients and 35 matched healthy controls were enroled. Patients received Mavacamten for 12 weeks. At baseline and post-treatment, we measured LVOT gradient, LVEF, GLS, myocardial work parameters [GWI, GCW, GWW, GWE], mitral regurgitation severity, and SAM.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Myocardial work parameters showed good reproducibility (ICCs &gt; 0.75). After 12 weeks, resting and provoked LVOT gradients significantly decreased (both <i>p</i> &lt; 0.001). Proportions of moderate/severe mitral regurgitation and SAM reduced. GWI, GCW, and GWW decreased (<i>p</i> &lt; 0.001), while GWE increased (<i>p</i> &lt; 0.001). NT-proBNP decreased and NYHA functional class improved (<i>p</i> &lt; 0.001). LVEF, GLS, and left atrial diameter showed no significant changes. Compared with controls, baseline oHCM patients had lower GWI, GCW, GWE and higher GWW (all <i>p</i> &lt; 0.001). After treatment, GWE remained lower than controls (<i>p</i> &lt; 0.001), and GWW remained higher (<i>p</i> &lt; 0.001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Twelve-week Mavacamten reduces LVOT obstruction in oHCM, accompanied by decreased GWI and increased GWE, while preserving systolic function and improving symptoms. Myocardial work parameters may serve as novel non-invasive references for treatment evaluation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148590679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Normative reference equations for leg discomfort during incremental cardiopulmonary cycle exercise testing in older adults","authors":"Rachelle Aucoin,&nbsp;Dennis Jensen,&nbsp;Michael Stickland,&nbsp;Andrew Brotto,&nbsp;Hayley Lewthwaite,&nbsp;Pei Zhi Li,&nbsp;Jean Bourbeau,&nbsp;Wan C. Tan,&nbsp;Magnus Ekström,&nbsp;CanCOLD Collaborative Research Group","doi":"10.1111/cpf.70083","DOIUrl":"10.1111/cpf.70083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Leg discomfort, assessed with the Borg category-ratio 0–10 (Borg CR10) scale, is a primary reason for exercise cessation in both health and disease. However, interpretation during cardiopulmonary exercise testing (CPET) is limited by the absence of normative reference equations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Develop normative reference equations for leg discomfort during CPET in relation to absolute and relative power output (W) and rate of oxygen uptake (V'O₂).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This was a retrospective analysis of the Canadian Cohort Obstructive Lung Disease (CanCOLD) study. We included healthy males and females aged ≥40 years who completed symptom limited incremental cycle CPET. The probability of each Borg CR10 leg discomfort rating by W or V'O₂ was predicted using multinomial logistic regression. Model performance was evaluated by fit, calibration, discrimination (c-statistic), and externally validated in an independent sample (<i>n</i> = 86) of healthy Canadian adults.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 156 participants (43% female) were included (mean age 64.8 years). The models demonstrated good discrimination in both internal and external validation (AUC 0.85–0.90), with similar performance across absolute and relative W and V'O_2. An upper limit of normal ([ULN]; 95th percentile) could not be defined, as leg discomfort responses were highly clustered within the predicted normal range across exercise intensities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>We present normative reference equations for leg discomfort during CPET. Although an ULN could not be established, these models enable grading and interpretation of leg discomfort relative to the predicted normal responses and facilitate comparisons across individuals and groups in both clinical and research settings.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13393339/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148561084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Myocardial perfusion reserve is low in heart transplant patients and is related to exercise capacity","authors":"Kristian Dimovski,&nbsp;Grunde Gjesdal,&nbsp;Katarina Steding-Ehrenborg,&nbsp;Robert Jablonowski,&nbsp;Hui Xue,&nbsp;Peter Kellman,&nbsp;Oscar Braun,&nbsp;Håkan Arheden,&nbsp;Henrik Engblom","doi":"10.1111/cpf.70082","DOIUrl":"https://doi.org/10.1111/cpf.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aims</h3>\u0000 \u0000 <p>Heart transplant (HTx) patients are known to be at risk of coronary microvascular dysfunction as well as having decreased exercise capacity. The aim of this study was to investigate if microvascular function in HTx patients differs from healthy controls and is related to objective measures of exercise capacity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods and Results</h3>\u0000 \u0000 <p>Twenty-nine HTx patients (51 ± 15 years, 34% women) and 26 healthy controls (57 ± 10 years, 38% women) underwent CMR. Quantitative myocardial perfusion maps were acquired using single-bolus (0.05 mmol/kg), dual-sequence perfusion mapping at adenosine stress and at rest. In addition, all HTx patients performed a maximal cardiopulmonary exercise test with gas-exchange analysis for objective assessment of exercise capacity. Heart transplant patients had lower stress myocardial perfusion (2.9 ± 0.8 vs 3.4 ± 0.8, <i>p</i> = 0.03) and lower myocardial perfusion reserve (MPR) (2.7 ± 0.7 vs 3.8 ± 1.2, <i>p</i> &lt; 0.001) compared to healthy controls. Furthermore, MPR in HTx patients was correlated with maximal workload (R² = 0.25, <i>p</i> = 0.016), O₂ pulse (R² = 0.21, <i>p</i> = 0.026), peak O₂ consumption (VO₂ peak) (R² = 0.25, <i>p</i> = 0.015) and O₂ consumption (VO₂) at the anaerobic threshold (AT) (R² = 0.27, <i>p</i> = 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Microvascular function as assessed by quantitative CMR perfusion mapping is lower in HTx patients than in healthy controls and is partly related to objective measures of exercise capacity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70082","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148467587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-invasive pressure–volume loop analysis in left ventricular load manipulation","authors":"Karin Pola,&nbsp;Charlotte Burup Kristensen,&nbsp;William D. Watson,&nbsp;Peregrine G. Green,&nbsp;Betty Raman,&nbsp;Stefan Neubauer,&nbsp;Oliver J. Rider,&nbsp;Christian Hassager,&nbsp;Rasmus Møgelvang,&nbsp;Per M. Arvidsson","doi":"10.1111/cpf.70081","DOIUrl":"10.1111/cpf.70081","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Clinical monitoring of patients with heart failure or cardiomyopathy is facilitated by detailed assessment of cardiac loading conditions. Specifically, alterations in preload and afterload may unmask pathology through effects on ventricular pressure–volume (PV) relations. Therefore, the aim was to assess non-invasive PV loops during left ventricular load manipulation in healthy participants and in patients with hypertrophic cardiomyopathy (HCM).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In total, <i>n</i> = 46 participants were studied in paired experiments at baseline and during load manipulation. Controls (<i>n</i> = 24) and patients with HCM (<i>n</i> = 14) were assessed at baseline and during intravenous infusion of 1.5–2 L isotonic saline, and another group of volunteers (<i>n</i> = 8) was assessed at baseline and during infusion of glyceryl trinitrate (GTN). Non-invasive PV loops were calculated from cardiovascular magnetic resonance (CMR) and concurrent brachial blood-pressure measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Saline infusion brought about increased end-diastolic and decreased end-systolic volumes in controls, but not in HCM. Concurrently, PV loops revealed mechanistic differences, where controls but not HCM exhibited decreased arterial elastance and potential energy during load manipulation. In both groups, ventricular-arterial coupling (VAC) decreased, and ventricular efficiency and cardiac output increased. Infusion of GTN resulted in decreased ventricular volumes. Contrary to saline infusion, volunteers receiving GTN retained unchanged arterial elastance, VAC, ventricular efficiency and cardiac output.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Non-invasive PV analysis from CMR detects cardiac response to altered loading conditions in healthy participants and in patients with HCM. Our findings support the use of CMR-derived PV loops for detailed assessment of cardiac thermodynamic performance in relation to interventions affecting preload and afterload.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70081","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra- and interrater reliability and inter-method correlations of soft tissue property measurements in the pectoral region of breast cancer survivors","authors":"Kaat Verbeelen,&nbsp;Ceren Gursen,&nbsp;Kaat Van Aperen,&nbsp;Michel GCAM Mertens,&nbsp;Nele Devoogdt,&nbsp;An De Groef","doi":"10.1111/cpf.70078","DOIUrl":"10.1111/cpf.70078","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Breast cancer treatments can alter local soft-tissue structure and mechanics, contributing to upper-limb dysfunction. Ultrasound (US) and shear-wave elastography (SWE) assess tissue stiffness, while deformation-based tools (Elastimeter, MyotonPRO) provide accessible alternatives, though their reliability and agreement are unclear. This study evaluated (1) intra- and interrater reliability of US, SWE, MyotonPRO and Elastimeter for measuring tissue thickness, composition and stiffness, and (2) correlations between SWE and deformation-based tools.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty breast cancer survivors were assessed at four pectoralis major regions on affected and non-affected sides. Skin, fat and muscle thickness, muscle composition, and stiffness were measured using US and SWE (MACH 30), with additional stiffness measures from MyotonPRO and Elastimeter. Three assessors performed repeated sessions. Reliability was analysed using ICC(3,1), SEM, %SEM, and SRD. Correlations were assessed with Spearman's coefficients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Muscle thickness and composition showed weak–moderate reliability (ICC 0.237–0.766). SWE stiffness also showed weak–moderate reliability (ICC −0.032–0.539) with large measurement error. Deformation-based tools showed similar reliability (ICC 0.246–0.737), with greatest variability for MyotonPRO. No significant correlations were found between SWE and deformation-based measures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>US measurements of skin and fat thickness were most reliable. Deeper-tissue assessments showed substantial variability, likely due to anatomical complexity, probe stability and device limitations. Stiffness tools were not interchangeable.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148390118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired muscle oxygenation recovery kinetics during the 6-min walk test in COPD and smokers: A near-infrared spectroscopy study","authors":"Buğra Kerget,&nbsp;İsmail Çınar,&nbsp;Kadir Çelik,&nbsp;Hatice Beyza Özkan,&nbsp;Sırma Merve Çetin","doi":"10.1111/cpf.70079","DOIUrl":"10.1111/cpf.70079","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Chronic obstructive pulmonary disease (COPD) is associated with impaired peripheral muscle oxygenation and reduced exercise tolerance. In our study, we planned to use near-infrared spectroscopy (NIRS) to measure muscle oxygenation dynamics during exercise in patients with COPD, active smokers and healthy individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This prospective study included 50 stable COPD patients, 30 current smokers without COPD and 20 healthy controls. Clinical measures and pulmonary function were assessed, while muscle oxygenation was continuously monitored by NIRS during the 6-min walk test (6MWT) to derive T½ recovery time, reoxygenation rate and functional exercise performance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>COPD patients had significantly lower muscle oxygen saturation (SmO₂) at baseline, end-6MWT and 5 min post-test than controls (<i>p</i> &lt; 0.001). COPD patients had the longest T½ recovery time (<i>p</i> = 0.03), and their reoxygenation rate was similar to that of active smokers but shorter than that of the healthy control group (<i>p</i> &lt; 0.001). Active smokers had lower SmO₂ and reoxygenation rates before and after exercise than the control group (<i>p</i> &lt; 0.05). In COPD patients, the greater the difference in oxygen saturation (SpO₂) levels before and after 6MWT, and the lower the haemoglobin level, the longer the T½ recovery time (<i>p</i> &lt; 0.05). The 6MWT interval was longer in those with high SpO₂ and SmO₂ levels before and after 6MWT, shorter T½ recovery times and high haemoglobin levels (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>COPD and smoking significantly impair post-exercise muscle oxygenation recovery, suggesting that peripheral microvascular dysfunction contributes to reduced functional exercise performance beyond pulmonary limitation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 4","pages":""},"PeriodicalIF":1.7,"publicationDate":"2026-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148367065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}