Effect of 7-day dietary supplementation with grape seed extract on cardiac autonomic and hemodynamic responses in elevated and stage 1 hypertension

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2025-05-08 DOI:10.1111/cpf.70010

Albert Lira, William Boyer, Trevor Gillum, Sean Sullivan, Jong-Kyung Kim

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引用次数: 0

Abstract

Backgrounds

Evidence indicated that an increase in nitric oxide (NO) bioavailability via dietary supplementation decreased sympathetic output. Grape seed extract (GSE) supplement has been known to increase NO production and improve endothelial function in individuals with elevated and stage 1 hypertension (ES1H), but no studies have assessed the effects of this extract on autonomic balance. Accordingly, the aim of the study was to investigate the effect of 7 days of dietary GSE supplementation on cardiac autonomic and hemodynamic responses.

Methods

Ten males were recruited in this study. Each subject received GSE or placebo supplementation with a 1-week wash-out period. In a double-blinded, cross-over design, hemodynamic responses (heart rate (HR), stroke volume (SV), cardiac output (CO), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean atrial pressure (MAP)), heart rate variability (HRV), and cold pressor test (CPT) were compared before and after either GSE or placebo supplementation.

Results

Our results indicated that GSE decreased resting DBP (75 ± 2 vs. 71 ± 3) and MAP (91 ± 2 vs. 88 ± 3) compared to the placebo (DBP:71 ± 3 vs. 74 ± 3; MAP: 89 ± 2 vs. 90 ± 2). However, MAP responses to CPT had no difference between post-PL and post-GSE supplementation when expressed as absolute increases (PL, Δ10.3 ± 1 mmHg, GSE, Δ9.1 ± 1 mmHg). There were no differences on the HR, SV, CO, SBP, and HRV between placebo and GSE treatments.

Conclusions

Our study suggests that GSE can be used as a dietary nutraceutical capable of reducing blood pressure and the risk of ES1H development. The reduction of blood pressure occurs via peripheral vasodilation, not associated with cardiac autonomic reactivity.

Abstract Image

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膳食补充葡萄籽提取物7天对高血压和1期高血压患者心脏自主神经和血流动力学反应的影响

有证据表明，通过膳食补充增加一氧化氮（NO）的生物利用度会降低交感神经输出。已知葡萄籽提取物（GSE）补充剂可以增加一氧化氮的产生并改善1期高血压（ES1H）患者的内皮功能，但没有研究评估这种提取物对自主神经平衡的影响。因此，本研究的目的是研究饲粮中添加7天GSE对心脏自主神经和血流动力学反应的影响。方法本研究招募10名男性。每位受试者接受GSE或安慰剂补充，洗脱期为1周。在双盲、交叉设计中，比较了GSE或安慰剂补充前后的血流动力学反应(心率（HR）、卒中量（SV）、心输出量（CO）、收缩压（SBP）、舒张压（DBP）、平均心房压（MAP）、心率变异性（HRV）和冷压试验（CPT）。结果与安慰剂相比，GSE可降低静息DBP（75±2比71±3）和MAP(91±2比88±3)(DBP:71±3比74±3；MAP: 89±2 vs. 90±2)。然而，当以绝对增加表示（PL， Δ10.3±1 mmHg， GSE， Δ9.1±1 mmHg）时，添加GSE后和添加GSE后对CPT的MAP反应没有差异。安慰剂组和GSE组在HR、SV、CO、SBP和HRV方面没有差异。结论GSE可作为一种膳食营养保健品，具有降低血压和降低ES1H发生风险的作用。血压的降低是通过外周血管舒张发生的，与心脏自主神经反应无关。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.