Clinical Physiology and Functional Imaging最新文献

{"title":"Diagnostic value of combined heart and lung ultrasound in emergency department patients with dyspnea","authors":"Anna Bjällmark,&nbsp;Gustaf Hummel,&nbsp;Kambiz Shahgaldi","doi":"10.1111/cpf.70009","DOIUrl":"https://doi.org/10.1111/cpf.70009","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Acute dyspnea in emergency departments (ED) requires prompt and accurate diagnosis due to its high mortality and readmission rates. Conventional diagnostic methods are resource-intensive and time-consuming. This study aimed to evaluate the diagnostic accuracy and time to diagnosis of combined heart and lung ultrasound (HeaLus) compared to standard emergency department evaluation in patients presenting with dyspnea.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective study was conducted in a cohort of 61 patients at the ED of Danderyd Hospital, Sweden. HeaLus examinations were performed alongside routine investigations. Diagnostic performance of HeaLus and ED evaluation was assessed for accuracy, sensitivity, specificity, positive predictive value, and negative predictive value, and agreement using Kappa index. Median time to diagnostics was compared between HeaLus and ED evaluation using Mann-Whitney U-test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Heart failure was the most common diagnosis (20%) among patients presenting with dyspnea. The diagnostic accuracy, sensitivity, specificity, positive predictive value, and negative predictive value were 95% (95% CI: [87%, 98%]), 98% (95% CI: [88%, 100%]), 90% (95% CI: [69%, 97%]), 95% (95% CI: [85%, 99%]), and 94% (95% CI: [74%, 99%]), respectively. The agreement between HeaLus and ED diagnoses was 0.88. Time to diagnosis was significantly reduced with HeaLus (21 min vs. 3 h and 28 min).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>HeaLus offers rapid and accurate assessment of dyspnea. These results suggest that HeaLus could be valuable in optimizing patient management, particularly in settings with limited resources and long ED wait times.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70009","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143840803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agreement of concomitant cardiac output measurement by thoracic bio-impedance and inert gas rebreathing in healthy subjects","authors":"Laura Filaire,&nbsp;Hélène Perrault,&nbsp;Claire Dauphin,&nbsp;Aurélie Chalard,&nbsp;Bruno Pereira,&nbsp;Frederic Costes,&nbsp;Ruddy Richard","doi":"10.1111/cpf.70005","DOIUrl":"https://doi.org/10.1111/cpf.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Inasmuch as they are deemed valid, noninvasive measurement of cardiac output techniques present advantages of ease and safety for use in humans. Few studies have compared the use of thoracic bioimpedance and inert gas rebreathing techniques for cardiac output (CO) assessment at rest and exercise. This manuscript reports on differences between Physioflow® and Innocor® CO measurements at rest and during cycling in a population of healthy subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty healthy subjects (52 ± 16 years) underwent an incremental cycle exercise testing (IET) during which standardized Physioflow® and Innocor® CO assessments were achieved. Measurements were completed in a subgroup of twelve subjects during two constant-load 10-min cycling bouts at moderate and high intensities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Mean difference between Physioflow® and Innocor® was of 0.002 ± 0.98 l/min at rest and 0.38 ± 1.31 l/min during IET without statistical difference. Correlation coefficient values were higher for exercise (<i>r</i> = 0.83) than resting (<i>r</i> = 0.40) measurements. Good reproducibility of the two devices was observed on different graded exercises with intraindividual variability lower than 6%, except for rest Innocor® CO measurements (CV = 18%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Physioflow® and Innocor® can be easily used concomitantly for noninvasive measurement of CO. Despite finding a strong agreement between techniques for exercise CO, results should not be interpreted as being interchangeable as values are derived from different flow measurements: systemic blood flow for Physioflow® and pulmonary blood flow for Innocor®. However, the concomitant use of both techniques could be of value in clinical setting for noninvasive intrathoracic shunt quantification.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 3","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143717179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ventilation/perfusion scintigraphy in patients with pulmonary vascular anomaly","authors":"Hamdi Afşin,&nbsp;Emine Afşin","doi":"10.1111/cpf.70008","DOIUrl":"10.1111/cpf.70008","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although ventilation/perfusion (V/Q) scintigraphy is frequently used in the diagnosis of acute or chronic pulmonary embolism (PE), it also plays a significant role in diagnosing pulmonary vascular diseases. Additionally, in the presence of a mismatch defect on V/Q scintigraphy, pulmonary vascular anomalies should be considered as a possible alternative to PE. For this reason, we aimed to present three cases with Swyer–James–MacLeod syndrome (SJMS), one of which was also complicated by PE, and one case with pulmonary artery hypoplasia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Case Presentation</h3>\u0000 \u0000 <p>Case 1: PE was diagnosed by V/Q scintigraphy in a patient with known SJMS. Case 2: SJMS was diagnosed by thoracic computed tomography (CT), flexible optical bronchoscopy (FOB) and V/Q scintigraphy. Case 3: V/Q scintigraphy revealed pulmonary artery hypoplasia in the differential diagnosis of PE when evaluated together with FOB and thoracic CT. Case 4: Diagnosed as SJMS by Thorax CT and V/Q scintigraphy in the presence of chronic lung disease.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>V/Q scintigraphy is also used in the diagnosis of congenital/hereditary vascular and airway diseases. Thoracic CT should be performed together with evaluation to reach the diagnosis in this group of patients. In cases with mismatch defects, vascular anomalies should also be considered in the differential diagnosis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143676673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood flow restriction during high load bench press does not increase bar velocity or cause physiological changes in non-occluded agonist muscles","authors":"Andrew LeMense,&nbsp;Abby Fleming,&nbsp;Samuel Gomez,&nbsp;John Lewis,&nbsp;Harrison Labanowski,&nbsp;Michael Fedewa,&nbsp;Lee Winchester","doi":"10.1111/cpf.70006","DOIUrl":"https://doi.org/10.1111/cpf.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Blood blow restriction (BFR) can increase peak velocity and power during high load resistance training. However, previous research primarily utilized high occlusion pressures (i.e., greater than 80% arterial occlusion pressure (AOP)), and rarely measured the physiological response during or after the bench press stimuli. The aim of this study was to investigate the application of 50%AOP during acute high load bench press exercise on barbell power, velocity, and the physiological responses to this stimulus.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Resistance trained males (<i>n</i> = 12, 26.2 ± 6.6 yrs., 84.0 ± 10.8 kg, 176.3 ± 10.4 cm) completed a maximum strength test followed by two experimental sessions which consisted of four sets of 4 reps of the barbell bench press at 75%1RM, with or without BFR applied to both arms at 50% AOP. Significance was set to <i>p</i> ≤ 0.05. A series of two-way repeated measures ANOVAs with Bonferroni post hoc corrections tested for potential changes in bar velocity, power, blood lactate, and muscle thickness and activation of the anterior deltoid and pectoralis major.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>There were no main effects for the interaction terms “Condition×Set” or “Condition×Time,” nor for “Condition” for any variables (all <i>p</i> &gt; 0.05). There was a “Time” effect for blood lactate (<i>p</i> &lt; 0.001) with lactate increasing from pre- to postexercise, and a main effects for “Set” for mean (<i>p</i> = 0.016) and peak velocity (<i>p</i> = 0.005).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>There was no difference in the change in velocity, or physiological responses during high load bench press with or without BFR at 50%AOP. While promising, use of BFR for upper body power may require pressures &gt;50%AOP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143645964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of consciously controlled slow breathing on cardiac parasympathetic nervous activity postexercise in young healthy males","authors":"Tatsuya Sugimoto,&nbsp;Kazuya Sugiyama,&nbsp;Kumi Matsumura,&nbsp;Kana Michiue,&nbsp;Kumiko Ono,&nbsp;Akira Ishikawa","doi":"10.1111/cpf.70007","DOIUrl":"https://doi.org/10.1111/cpf.70007","url":null,"abstract":"<p>The purpose of the present study was to clarify the effects of consciously controlled slow breathing on cardiac parasympathetic nervous activity Postexercise. Fifteen young healthy adult men participated in this study. They exercised on the bicycle ergometer at 50% of peak oxygen uptake for 10 min and then rested on the chair for 10 min. Two conditions were performed, namely slow breathing at 6 breaths per minute (SLOW) and spontaneous breathing (CON) at recovery phase in randomized order. We measured the oxygen uptake (<i>V̇</i>_O2), respiratory rate (RR), minute ventilation (<i>V̇</i>_E), tidal volume (<i>V</i>_T), ventilatory equivalents for carbon dioxide excretion (<i>V̇</i>_E/<i>V̇</i>_CO2), heart rate (HR), and R-R intervals. From the R-R intervals, we calculated the coefficient of variation of the R-R intervals (CVRR), the natural logarithms of the high-frequency (lnHF), and the natural logarithms of the sum of the components from very low- to high-frequency (total power: lnTP). There were no significant differences between conditions in <i>V̇</i>_O2 at exercise phase. At recovery phase in SLOW compared with CON, RR and <i>V̇</i>_E/<i>V̇</i>_CO2 were significantly decreased (both <i>p</i> &lt; 0.001) with a slight decrease in <i>V̇</i>_E, and <i>V</i>_T was increased (<i>p</i> &lt; 0.001). At recovery phase, while HR and lnHF had no differences between conditions, lnTP and CVRR were significantly higher in SLOW compared with CON (<i>p</i> &lt; 0.05) and baseline phase (<i>p</i> &lt; 0.05). In conclusion, slow breathing at six breaths per minute accelerated the reactivation of cardiac parasympathetic nervous activity Postexercise, accompanied by improved efficiency of pulmonary gas exchange due to a slight decrease in <i>V̇</i>_E.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143612412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diaphragm thickness and physical performance in regular smokers and non-smokers: A pilot study","authors":"Bahar Özgül,&nbsp;Zübeyir Sarı,&nbsp;İlkşan Demirbüken,&nbsp;Hilal Başak Can,&nbsp;Zana Gezer,&nbsp;Halil Yıldırım,&nbsp;Mine Gülden Polat","doi":"10.1111/cpf.70003","DOIUrl":"https://doi.org/10.1111/cpf.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite the understanding of the role of diaphragm role as a crucial element in trunk stabilizer performance, limited research has been carried out on the diaphragmatic features particularly in smoking population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>It was aimed to compare the diaphragm structure beside trunk stabilizer performance &amp; body balance of young regular smokers and non-smokers and investigate the relationship between diaphragmatic features and physical performance in regular smokers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Asymptomatic regular smoker (<i>n</i> = 22) and nonsmoker (<i>n</i> = 22) young male subjects (21.63 ± 2.37 years) were participated to the study. The diaphragmatic ultrasonic scanning and physical performance tests of core muscle strength and endurance &amp; Y balance test were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The duration of prone and lateral side bridge (<i>t</i> = −3.347, <i>t</i> = 3.477, <i>p</i> &lt; 0.001), and modify push-up test repetition (<i>Z</i> = −2.213, <i>p</i> = 0.027) were detected lower in regular smokers. A positive moderate correlation was observed between the duration of the prone bridge test and the maximum inspiration thickness &amp; the thickness difference at inspiration and expiration (<i>r</i> = 0.545, <i>p</i> = 0.009 &amp; <i>r</i> = 0.468, <i>p</i> = 0.028) and between the number of repetitions of the modify push-up and the maximum expiration thickness (<i>r</i> = 0.530, <i>p</i> = 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While no difference was detected in terms of the diaphragm structure between groups, trunk stabilizer performance was lower and greater diaphragm thickness was associated with better trunk stability in some performance tasks in smokers. While the diaphragm muscle structure, which is the main respiratory muscle, does not differ in young smokers, the effects of the diaphragm muscle on general body biomechanics have been preliminary demonstrated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum detectable change estimates of heart-to-finger arterial pulse wave conduction time in cardiovascular-healthy young adults","authors":"Harvey N. Mayrovitz","doi":"10.1111/cpf.70002","DOIUrl":"https://doi.org/10.1111/cpf.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pulse wave velocity (PWV) measurements are the gold standard for assessing arterial stiffness and estimating time or treatment-related changes in cardiovascular status. What constitutes a statistically significant change is an important clinical consideration. This study aimed to describe the variability of heart-to-finger pulse wave conduction time (PWCT) to provide estimates of the minimum detectable change (MDC) dependent on the number of PWCT samples used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>Heart-to-finger PWCT was measured based on the time delay between the peak of the EKG R-wave and arterial pulse arrival at the left hand index finger as measured by a photoplethysmographic sensor. Measurements were done in 10 young adults (25.7 ± 1.2 years) while supine for 45 min. Depending on the subject's heart rate, these measurements yielded 2430 to 3750 contiguous PWCT for analysis. The variability in these PWCTs was used to determine the minimal detectable percentage change for specified p-values of 0.05, 0.01, and 0.001.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sample sizes of 10, 30, 50, or 300 contiguous PWCTs yield similar MDC estimates for a given targeted <i>p</i>-value. The MDC% depended on the chosen <i>p</i>-value, with values of MDC% for <i>p</i>-values of 0.05, 0.01, and 0.001 being 7.8%, 10.5%, and 13.6%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The estimates may help plan experiments when changes or differences in PWCT or PWV are of interest. Also, these MDC estimates may help assess the validity of clinical study outcomes if PWV changes are outcome measures. The main limitation of the estimates is that they are based on 10 healthy subjects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SVAT–sonographic thickness ratio of visceral adipose tissue to anterior thigh muscle: a novel approach for body composition analysis","authors":"Murat Kara,&nbsp;Ahmad J. Abdulsalam,&nbsp;Vincenzo Ricci,&nbsp;Levent Özçakar","doi":"10.1111/cpf.70004","DOIUrl":"https://doi.org/10.1111/cpf.70004","url":null,"abstract":"<p>Body composition analysis is essential for assessing health and fitness, providing insights into fat and muscle distribution in the body and serving as a vital indicator for various conditions. Traditional methods often lack precision, but ultrasound (US) has emerged as a noninvasive alternative. The intra-abdominal visceral adipose tissue to quadriceps muscle thickness ratio emerges as a significant indicator of metabolic health, offering clinicians a valuable tool for personalized interventions. With US, it represents a significant advancement in body composition analysis, promising detailed insights with its noninvasive and real-time imaging capabilities, likely expanding its role in improving human health assessment and interventions.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary blood volume as a marker of adenosine-induced cardiac hyperemia: A Rubidium-82 study","authors":"Martin Lyngby Lassen,&nbsp;Jacob Peter Hartmann,&nbsp;Christina Byrne,&nbsp;Ronan M. G. Berg,&nbsp;Andreas Kjær,&nbsp;Philip Hasbak","doi":"10.1111/cpf.70001","DOIUrl":"https://doi.org/10.1111/cpf.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate the efficacy of pulmonary blood volume (PBV) as a marker of the cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty healthy subjects underwent four consecutive Rubidium-82 rest/adenosine-stress MPI: two sessions were conducted without any caffeine consumption (baseline), while the remaining two sessions involved controlled caffeine consumption (arm 1: 100 and 300 mg; arm 2: 200 and 400 mg). We evaluate the ability of the stress-to-rest ratio of PBV (PBV ratio) to identify an adequate cardiac hyperemic response. The adequate hyperemic response was defined as a stress myocardial blood flow &gt;2 mL/g/min and a corresponding myocardial flow reserve &gt;68% of the maximum myocardial flow reserve obtained during the baseline scans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on 126 MPI sessions conducted in 40 subjects, the PBV ratio demonstrated a sensitivity of 78% and a specificity of 74% in detecting adequate cardiac hyperemia. The positive predictive value was 95%, while the negative predictive value was 36%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The PBV ratio permits the identification of adequate hyperemic response with sensitivities and specificities comparable to existing markers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal clearance estimated by rubidium-82 positron emission tomography/computed tomography and technetium-99m-mercaptoacetyltriglycine clearance infusion technique","authors":"Stine Sundgaard Langaa,&nbsp;Camilla Lundgreen Duus,&nbsp;Marie Houmaa Vrist,&nbsp;Frank Holden Mose,&nbsp;Claire Anne Fynbo,&nbsp;Jørn Theil,&nbsp;June Anita Ejlersen,&nbsp;Jesper Nørgaard Bech","doi":"10.1111/cpf.70000","DOIUrl":"https://doi.org/10.1111/cpf.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (⁸²Rb) positron emission tomography/computed tomography (PET/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal ⁸²Rb clearance with renal technetium-99m-mercaptoacetyltriglycine ([^99mTc]Tc-MAG3) clearance as a first attempt to validate ⁸²Rb PET/CT for renal perfusion estimation using a reference method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten subjects with essential hypertension underwent two treatment periods, receiving spironolactone and placebo in random order. At the end of each period, each subject completed a ⁸²Rb PET/CT scan and a [^99mTc]Tc-MAG3 clearance study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>⁸²Rb clearance correlated positively with [^99mTc]Tc-MAG3 clearance in both treatment periods. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratio was 0.83 and 0.86 in the placebo and spironolactone treatment periods, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The correlation between ⁸²Rb clearance and [^99mTc]Tc-MAG3 clearance may indicate that PET/CT determined ⁸²Rb clearance can act as an estimator of renal perfusion. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratios suggest that the extraction fraction of ⁸²Rb is higher than that of [^99mTc]Tc-MAG3, further suggesting ⁸²Rb clearance as an estimator of flow. However, further studies are warranted to validate use of ⁸²Rb PET/CT for flow estimation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}