Clinical Physiology and Functional Imaging最新文献

{"title":"Diaphragm thickness and physical performance in regular smokers and non-smokers: A pilot study","authors":"Bahar Özgül,&nbsp;Zübeyir Sarı,&nbsp;İlkşan Demirbüken,&nbsp;Hilal Başak Can,&nbsp;Zana Gezer,&nbsp;Halil Yıldırım,&nbsp;Mine Gülden Polat","doi":"10.1111/cpf.70003","DOIUrl":"https://doi.org/10.1111/cpf.70003","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Despite the understanding of the role of diaphragm role as a crucial element in trunk stabilizer performance, limited research has been carried out on the diaphragmatic features particularly in smoking population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>It was aimed to compare the diaphragm structure beside trunk stabilizer performance &amp; body balance of young regular smokers and non-smokers and investigate the relationship between diaphragmatic features and physical performance in regular smokers.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Asymptomatic regular smoker (<i>n</i> = 22) and nonsmoker (<i>n</i> = 22) young male subjects (21.63 ± 2.37 years) were participated to the study. The diaphragmatic ultrasonic scanning and physical performance tests of core muscle strength and endurance &amp; Y balance test were performed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The duration of prone and lateral side bridge (<i>t</i> = −3.347, <i>t</i> = 3.477, <i>p</i> &lt; 0.001), and modify push-up test repetition (<i>Z</i> = −2.213, <i>p</i> = 0.027) were detected lower in regular smokers. A positive moderate correlation was observed between the duration of the prone bridge test and the maximum inspiration thickness &amp; the thickness difference at inspiration and expiration (<i>r</i> = 0.545, <i>p</i> = 0.009 &amp; <i>r</i> = 0.468, <i>p</i> = 0.028) and between the number of repetitions of the modify push-up and the maximum expiration thickness (<i>r</i> = 0.530, <i>p</i> = 0.011).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>While no difference was detected in terms of the diaphragm structure between groups, trunk stabilizer performance was lower and greater diaphragm thickness was associated with better trunk stability in some performance tasks in smokers. While the diaphragm muscle structure, which is the main respiratory muscle, does not differ in young smokers, the effects of the diaphragm muscle on general body biomechanics have been preliminary demonstrated.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143554697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Minimum detectable change estimates of heart-to-finger arterial pulse wave conduction time in cardiovascular-healthy young adults","authors":"Harvey N. Mayrovitz","doi":"10.1111/cpf.70002","DOIUrl":"https://doi.org/10.1111/cpf.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pulse wave velocity (PWV) measurements are the gold standard for assessing arterial stiffness and estimating time or treatment-related changes in cardiovascular status. What constitutes a statistically significant change is an important clinical consideration. This study aimed to describe the variability of heart-to-finger pulse wave conduction time (PWCT) to provide estimates of the minimum detectable change (MDC) dependent on the number of PWCT samples used.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and methods</h3>\u0000 \u0000 <p>Heart-to-finger PWCT was measured based on the time delay between the peak of the EKG R-wave and arterial pulse arrival at the left hand index finger as measured by a photoplethysmographic sensor. Measurements were done in 10 young adults (25.7 ± 1.2 years) while supine for 45 min. Depending on the subject's heart rate, these measurements yielded 2430 to 3750 contiguous PWCT for analysis. The variability in these PWCTs was used to determine the minimal detectable percentage change for specified p-values of 0.05, 0.01, and 0.001.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sample sizes of 10, 30, 50, or 300 contiguous PWCTs yield similar MDC estimates for a given targeted <i>p</i>-value. The MDC% depended on the chosen <i>p</i>-value, with values of MDC% for <i>p</i>-values of 0.05, 0.01, and 0.001 being 7.8%, 10.5%, and 13.6%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The estimates may help plan experiments when changes or differences in PWCT or PWV are of interest. Also, these MDC estimates may help assess the validity of clinical study outcomes if PWV changes are outcome measures. The main limitation of the estimates is that they are based on 10 healthy subjects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143535990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SVAT–sonographic thickness ratio of visceral adipose tissue to anterior thigh muscle: a novel approach for body composition analysis","authors":"Murat Kara,&nbsp;Ahmad J. Abdulsalam,&nbsp;Vincenzo Ricci,&nbsp;Levent Özçakar","doi":"10.1111/cpf.70004","DOIUrl":"https://doi.org/10.1111/cpf.70004","url":null,"abstract":"<p>Body composition analysis is essential for assessing health and fitness, providing insights into fat and muscle distribution in the body and serving as a vital indicator for various conditions. Traditional methods often lack precision, but ultrasound (US) has emerged as a noninvasive alternative. The intra-abdominal visceral adipose tissue to quadriceps muscle thickness ratio emerges as a significant indicator of metabolic health, offering clinicians a valuable tool for personalized interventions. With US, it represents a significant advancement in body composition analysis, promising detailed insights with its noninvasive and real-time imaging capabilities, likely expanding its role in improving human health assessment and interventions.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-03-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143527712","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary blood volume as a marker of adenosine-induced cardiac hyperemia: A Rubidium-82 study","authors":"Martin Lyngby Lassen,&nbsp;Jacob Peter Hartmann,&nbsp;Christina Byrne,&nbsp;Ronan M. G. Berg,&nbsp;Andreas Kjær,&nbsp;Philip Hasbak","doi":"10.1111/cpf.70001","DOIUrl":"https://doi.org/10.1111/cpf.70001","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To investigate the efficacy of pulmonary blood volume (PBV) as a marker of the cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty healthy subjects underwent four consecutive Rubidium-82 rest/adenosine-stress MPI: two sessions were conducted without any caffeine consumption (baseline), while the remaining two sessions involved controlled caffeine consumption (arm 1: 100 and 300 mg; arm 2: 200 and 400 mg). We evaluate the ability of the stress-to-rest ratio of PBV (PBV ratio) to identify an adequate cardiac hyperemic response. The adequate hyperemic response was defined as a stress myocardial blood flow &gt;2 mL/g/min and a corresponding myocardial flow reserve &gt;68% of the maximum myocardial flow reserve obtained during the baseline scans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Based on 126 MPI sessions conducted in 40 subjects, the PBV ratio demonstrated a sensitivity of 78% and a specificity of 74% in detecting adequate cardiac hyperemia. The positive predictive value was 95%, while the negative predictive value was 36%.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The PBV ratio permits the identification of adequate hyperemic response with sensitivities and specificities comparable to existing markers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143489819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Renal clearance estimated by rubidium-82 positron emission tomography/computed tomography and technetium-99m-mercaptoacetyltriglycine clearance infusion technique","authors":"Stine Sundgaard Langaa,&nbsp;Camilla Lundgreen Duus,&nbsp;Marie Houmaa Vrist,&nbsp;Frank Holden Mose,&nbsp;Claire Anne Fynbo,&nbsp;Jørn Theil,&nbsp;June Anita Ejlersen,&nbsp;Jesper Nørgaard Bech","doi":"10.1111/cpf.70000","DOIUrl":"https://doi.org/10.1111/cpf.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (⁸²Rb) positron emission tomography/computed tomography (PET/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal ⁸²Rb clearance with renal technetium-99m-mercaptoacetyltriglycine ([^99mTc]Tc-MAG3) clearance as a first attempt to validate ⁸²Rb PET/CT for renal perfusion estimation using a reference method.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten subjects with essential hypertension underwent two treatment periods, receiving spironolactone and placebo in random order. At the end of each period, each subject completed a ⁸²Rb PET/CT scan and a [^99mTc]Tc-MAG3 clearance study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>⁸²Rb clearance correlated positively with [^99mTc]Tc-MAG3 clearance in both treatment periods. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratio was 0.83 and 0.86 in the placebo and spironolactone treatment periods, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The correlation between ⁸²Rb clearance and [^99mTc]Tc-MAG3 clearance may indicate that PET/CT determined ⁸²Rb clearance can act as an estimator of renal perfusion. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratios suggest that the extraction fraction of ⁸²Rb is higher than that of [^99mTc]Tc-MAG3, further suggesting ⁸²Rb clearance as an estimator of flow. However, further studies are warranted to validate use of ⁸²Rb PET/CT for flow estimation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 2","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-02-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Test-retest reliability of cardiopulmonary exercise test-derived metrics in individuals with COPD versus healthy controls","authors":"Milan Mohammad,&nbsp;Rie S. Thomsen,&nbsp;Iben E. Rasmussen,&nbsp;Amalie B. Andersen,&nbsp;Jacob P. Hartmann,&nbsp;Ronan M. G. Berg","doi":"10.1111/cpf.12927","DOIUrl":"10.1111/cpf.12927","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cardiopulmonary exercise testing (CPET) is usually considered the gold standard for assessing maximal oxygen consumption (V̇O_2max), a health and performance marker in patients with chronic obstructive pulmonary disease (COPD). Despite the widespread application of CPET, the absolute and relative test-retest reliability of CPET-derived metrics remains unexamined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To examine and compare test-retest reliability of CPET derived metrics in individuals with COPD and healthy matched controls.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>12 individuals with COPD and 12 healthy age- and sex-matched controls were included in this case-control study. Each participant completed two CPET on a bicycle ergometer on two different days. Absolute reliability was reported as smallest real difference (SRD) and relative reliability as coefficient of variance (CV) and intraclass correlation coefficients (ICC).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Main Results</h3>\u0000 \u0000 <p>SRD for peak oxygen uptake was 451.6 (267.4;1006.4) mL/min and CV was 7.8 (4.7;11.0)% in patients with COPD, whereas SRD was 244.2 (151.4;491.5) mL/min and CV was 3.0 (1.8;4.2)% in healthy controls but with no significant between group difference for SRD. CV values for all CPET derived metrics were found to be below 10%. Apart from peak workload achieved and peak minute ventilation, SRD and CV were significantly higher in COPD than in controls for all other CPET-derived metrics.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study provides test-retest reliability estimates of the most widely used CPET derived metrics in individuals with COPD and healthy matched controls. Test-retest reliability for most metrics derived from CPET were found to be lower in individuals with COPD when compared to healthy controls.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776364/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143058211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Blood flow restriction combined with nordic hamstring exercise does not impair endothelial function but does not increase neuromuscular activation","authors":"Fuat Yuksel,&nbsp;Nevin Guzel,&nbsp;Ömer Burak Tor,&nbsp;Koray Akkan","doi":"10.1111/cpf.12926","DOIUrl":"https://doi.org/10.1111/cpf.12926","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Optimizing hamstring exercises is crucial for injury prevention and performance. This study explored the effects of blood flow restriction (BFR) during Nordic hamstring exercises (NHE) on hamstring muscle activation and vascular function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A randomized, single-blind study included 14 healthy, physically active males (mean age: 27.5 years). Each participant's lower extremities were randomly assigned to BFR or control groups. In the BFR group, blood flow was restricted to 60% of arterial occlusion pressure. Participants performed three sets of five NHE repetitions. Endothelial function was assessed by flow-mediated dilation (FMD) via Doppler ultrasound before and after exercise. Surface electromyography (EMG) recorded neuromuscular activation of the semitendinosus (ST) and biceps femoris (BF) muscles during exercises.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>FMD values showed no significant differences between BFR and control groups (F(1,13) = 0.156, <i>p</i> = 0.7, partial η² = 0.012). Neuromuscular activations of ST and BF muscles decreased across sets in both groups but did not differ significantly between groups (ST: F(2,26) = 1.172, <i>p</i> = 0.448, partial η² = 0.09; BF: F(2,26) = 1.442, <i>p</i> = 0.527, partial η² = 0.1).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>BFR did not produce acute additional effects on muscle activation or endothelial function compared to standard NHE. This suggests that incorporating BFR in NHE may not enhance immediate neuromuscular or vascular responses. Further research is needed to evaluate its long-term benefits.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143112613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of blood flow restriction intensity on pain perception and muscle recovery post-eccentric exercise","authors":"Ozgur Surenkok,&nbsp;Gamze Aydin,&nbsp;Ebru Aloglu Ciftci,&nbsp;Kubra Kendal,&nbsp;Emine Atici","doi":"10.1111/cpf.12925","DOIUrl":"10.1111/cpf.12925","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Delayed onset muscle soreness (DOMS) is a well-established phenomenon characterized by ultrastructural muscle damage that typically develops following unfamiliar or high-intensity exercise. DOMS manifests with a constellation of symptoms, including muscle tenderness, stiffness, edema, mechanical hyperalgesia, and a reduced range of joint motion. In recent years, the application of blood flow restriction (BFR) has garnered attention for its potential impact on DOMS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study aimed to investigate the effects of different BFR intensities on biomechanical alterations induced by DOMS in healthy individuals.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Design and Methods</h3>\u0000 \u0000 <p>Thirty participants were split into two groups receiving either 80% or 20% BFR applied during low-intensity resistance exercise following DOMS induction. Pain perception, pressure pain threshold, muscle biometric characteristics, and strength were assessed before DOMS, after DOMS, and following BFR application at 24, 48, and 72 h.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 80% BFR group experienced faster reductions in pain perception compared to the 20% BFR group. Muscle strength recovery was also statistically faster in the 80% BFR group. No significant differences were observed between groups in muscle stiffness, flexibility, or other mechanical properties.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>These findings suggest that BFR, particularly at higher intensities, may alleviate DOMS symptoms and accelerate muscle strength recovery. However, the lack of a control group and limitations in muscle property assessment warrant further research to definitively determine BFR's efficacy in managing DOMS.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142906802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positive effect of erythromycin on ineffective oesophageal motility in laryngopharyngeal reflux patients: Room for a novel treatment?","authors":"Fienne Sime,&nbsp;David Tovmassian,&nbsp;Gregory L. Falk","doi":"10.1111/cpf.12924","DOIUrl":"10.1111/cpf.12924","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Laryngopharyngeal reflux (LPR) management guidelines are currently derived from the management of gastroesophageal reflux disease (GORD) which has been shown to be poorly effective in controlling symptoms for these patients. Erythromycin is a macrolide antibiotic that has been used extensively as a prokinetic agent for the gastrointestinal tract. The management of LPR with prokinetics is a novel therapy being investigated with regard to its effectiveness. The purpose of this pilot study was to observe the effect of erythromycin on oesophageal motility with high resolution manometry (HRM) to establish if further study is warranted regarding its utility in management.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Consecutive patients were retrospectively identified from a prospectively maintained database at a single centre of patients with findings suggestive of LPR who had also undergone HRM. These patients all received lifestyle modification and erythromycin 250 mg BD with repeat HRM after 6 weeks of therapy.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>16 patients met inclusion criteria. Mean age was 56.2 ± 14.9. Mean ineffective swallows were 54.38% ± 41.3% compared with 34.4% ± 35.2% pre and post-erythromycin therapy (<i>p</i> = 0.018). Mean distal contractile integral at baseline was 793.61 ± 854.96 mmHg at baseline increasing to 1347 ± 1094.73 mmHg after erythromycin therapy (<i>p</i> = 0.013). IRP also showed improvement from 8.99 ± 7.58 increasing to 10.93 ± 7.9 mmHg (<i>p</i> = 0.045). Subgroup analysis of patients with ineffective oesophageal motility reinforced above findings as well as increase in the amount of ‘normal’ peristalsis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This pilot study shows early evidence that erythromycin improves oesophageal motility. Further study is warranted to explore these findings in more detail.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142902797","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of semiquantitative analysis of [99mTc]MDP SPECT/CT in localizing responsible lesions for suspected fresh osteoporotic vertebral compression fractures in patients with contraindications to MRI","authors":"Sheng Shi,&nbsp;Hai-Dong Cai,&nbsp;Gai-Xia Lu,&nbsp;Li-Guo Zhang,&nbsp;Shuang Zheng,&nbsp;Shi-Sheng He","doi":"10.1111/cpf.12923","DOIUrl":"10.1111/cpf.12923","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The aim of this study was to evaluate the effectiveness of single-photon emission computed tomography/computed tomography (SPECT/CT) in detecting and localizing the causative vertebra in cases of suspected fresh osteoporotic vertebral compression fractures (OVCFs) in patients with contraindications to MRI.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 21 patients with severe back pain with 31 suspected OVCF segments and contraindications to MRI were initially identified through radiographs and the back pain-inducing test (BPIT). The responsible vertebral bodies were determined using [^99mTc]MDP SPECT/CT before percutaneous vertebroplasty (PVP). Clinical outcomes and radiographic parameters, including basic demographics, injury duration, focal kyphosis (FK), loss of vertebral height (LVH), and relative intensity values (RIVs) for target and nontarget segments in the SPECT/CT were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>SPECT/CT identified 14 old and 26 fresh OVCFs. Of these, 18 patients with 26 fresh OVCF segments underwent PVP, and achieved satisfactory outcomes. Significant differences were observed in the RIV, FK, and LVH values between the fresh and old OCVF groups (all <i>p</i> &lt; 0.05). RIVs showed a significant negative correlation with injury duration (r = −0.57, <i>p</i> &lt; 0.05), and a positive correlation with LVH (r = 0.43, <i>p</i> &lt; 0.05). Multiple linear regression analysis confirmed that injury duration was an independent predictor of RIVs (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SPECT/CT is useful for detecting and differentiating fresh fractures from old fractures in patients having OVCF who cannot undergo MRI after BPIT validation, allowing these patients to achieve excellent clinical outcomes following PVP. The RIV serves as a valuable parameter for assessing the duration of fresh versus old OVCFs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ChiCTR, ChiCTR 2300077570. Retrospectively registered, http://www.chictr.org.cn/showproj.html?proj=206192.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892094","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}