Evaluation of [18F]PSMA-1007 uptake variability in patients with prostate cancer

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2025-06-15 DOI:10.1111/cpf.70016

Elin Trägårdh, Måns Larsson, David Minarik, Olof Enqvist, Lars Edenbrandt

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引用次数: 0

Abstract

Background

The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [¹⁸F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients.

Methods

A total of 1086 patients who underwent PSMA PET-CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion uptake (TLU) were calculated from manual segmentations. The mean standardized uptake value (SUV_mean) in the organs at risk kidneys, liver, parotid glands and spleen was obtained. Correlations between TLV/TLU and SUV_mean in normal tissues were calculated using Spearman rank correlation. SUV_mean in normal tissues was stratified into groups based on TLV.

Results

The median (IQR) SUV_mean of the kidneys, liver, parotid glands, and spleen was 13.1 (IQR 4.6), 11.8 (4.4), 18.6 (6.8) and 11.3 (5.8), respectively. The median TLV was 3.8 cm³ (9.7) and median TLU was 31.2 cm³ (106.3). There was no significant correlation between TLV or TLU and SUV_mean for the liver, parotid glands, or spleen, but a weak negative correlation between TLV/TLU and SUV_mean in the kidneys (r = −0.011, p = 0.0005; r = −0.09, p = 0.003). There was a tendency towards a lower SUV_mean in the kidneys and parotid glands in patients with a very high TLV.

Conclusions

There was a large uptake variability in organs at risk, which demonstrates the need for individual pretherapy dosimetry. There may be a tumour sink effect in the kidneys and parotid glands in patients with a very high TLV.

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前列腺癌患者PSMA-1007摄取变异性的评价[18F]

背景psma配体的生物分布在放射性核素治疗计划中具有重要意义。我们研究了前列腺癌患者危险器官中[18F]PSMA-1007摄取的变异性以及与肿瘤负荷的关系。方法对1086例经PSMA PET-CT检查前列腺癌分期或复发的患者进行分析。通过人工分割计算病灶总体积（TLV）和病灶总摄取（TLU）。获得危险器官肾脏、肝脏、腮腺和脾脏的平均标准化摄取值（SUVmean）。采用Spearman秩相关计算正常组织TLV/TLU与SUVmean的相关性。正常组织的SUVmean按TLV分层。结果肾脏、肝脏、腮腺和脾脏的中位（IQR） SUVmean分别为13.1 （IQR 4.6）、11.8（4.4）、18.6（6.8）和11.3（5.8）。中位TLV为3.8 cm3(9.7)，中位TLU为31.2 cm3（106.3）。肝脏、腮腺和脾脏的TLV或TLU与SUVmean无显著相关，但肾脏的TLV/TLU与SUVmean呈弱负相关(r = - 0.011, p = 0.0005；R =−0.09,p = 0.003)。高TLV患者的肾脏和腮腺有较低的SUVmean的趋势。结论：在危险器官中有很大的摄取变异性，这表明有必要进行个体化治疗前剂量测定。高TLV患者的肾脏和腮腺可能存在肿瘤沉降效应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.