Clinical Physiology and Functional Imaging最新文献

{"title":"Effects of different exercises on respiratory parameters: A randomized controlled trial","authors":"Hasan Gercek,&nbsp;Bayram S. Unuvar,&nbsp;Kamil Yilmaz,&nbsp;Ozlem Akkoyun Sert,&nbsp;Sinan Bagcaci","doi":"10.1111/cpf.12804","DOIUrl":"10.1111/cpf.12804","url":null,"abstract":"<p>This study was designed to compare the effects of core stabilisation (CS) and auxiliary respiratory muscle strengthening exercises on oxygen consumption and respiratory parameters. A total of 51 participants were divided into three groups with block randomization method according to age and gender: CS Group (<i>n</i> = 17), Auxiliary Respiratory Muscles Exercise (ARM) Group (<i>n</i> = 17) and Control (C) Group (<i>n</i> = 17). Maximum oxygen uptake (VO₂max), first second of forced expiration (FEV1)/Forced vital capacity (FVC) and maximal voluntary ventilation (MVV) values were evaluated before and after the study. CS and ARM strengthening exercises were applied 3 days a week for 6 weeks. The increase in the FEV1/VC values was higher in the CS and ARM groups than in the C group (<i>p</i> &lt; 0.05), whereas no statistically significant difference was observed between the ARM and CS groups (<i>p</i> &lt; 0.05). There was no statistically significant difference between the groups in terms of VO₂max values before and after the study (<i>p</i> &gt; 0.05). The increase in the MVV values was higher in the CS and ARM groups than in the C group (<i>p</i> &lt; 0.05), whereas no statistically significant difference was observed between the ARM and CS groups (<i>p</i> &gt; 0.05). CS and ARM exercises had positive effects on FEV1/FVC and MVV.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detailed investigation of multiple resting cardiovascular parameters in relation to physical fitness","authors":"Lars Lind,&nbsp;Karl Michaëlsson","doi":"10.1111/cpf.12800","DOIUrl":"10.1111/cpf.12800","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Maximal oxygen consumption at an exercise test (VO₂-max) is a commonly used marker of physical fitness. In the present study, we aimed to find independent clinical predictors of VO₂-max by use of multiple measurements of cardiac, respiratory and vascular variables collected while resting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>In the Prospective study of Obesity, Energy and Metabolism (POEM), 420 subjects aged 50 years were investigated regarding endothelial function, arterial compliance, heart rate variability, arterial blood flow and atherosclerosis, left ventricular structure and function, lung function, multiple blood pressure measurements, lifestyle habits, body composition and in addition a maximal bicycle exercise test with gas exchange (VO₂ and VCO₂).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>When VO₂-max (indexed for lean mass) was used as the dependent variable and the 84 hemodynamic or metabolic variables were used as independent variables in separate sex-adjusted models, 15 variables showed associations with <i>p</i> &lt; 0.00064 (Bonferroni-adjusted). Eight independent variables explained 21% of the variance in VO₂-max. Current smoking and pulse wave velocity (PWV) were the two major determinants of VO₂-max (explaining each 7% and 3% of the variance; <i>p</i> &lt; 0.0001 and <i>p</i> = 0.008, respectively). They were in order followed by vital capacity, fat mass, pulse pressure, and high-density lipoprotein (HDL)-cholesterol. The relationships were inverse for all these variables, except for vital capacity and HDL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Several metabolic, cardiac, respiratory and vascular variables measured at rest explained together with smoking 21% of the variation in VO₂-max in middle-aged individuals. Of those variables, smoking and PWV were the most important.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12800","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9324958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of the mechanosensitive piezo1 channel in intervertebral disc degeneration","authors":"Sheng Guo,&nbsp;Chenglong Wang,&nbsp;Changming Xiao,&nbsp;Qinwen Gu,&nbsp;Longhai Long,&nbsp;Xiaoqiang Wang,&nbsp;Houping Xu,&nbsp;Sen Li","doi":"10.1111/cpf.12798","DOIUrl":"10.1111/cpf.12798","url":null,"abstract":"<p>Intervertebral disc degeneration (IDD) is a multifactorial skeletal disease involving mechanical, genetic, systemic, and biological factors, and it is characterized by apoptosis of the nucleus pulposus cells and breakdown of the extracellular matrix (ECM), which will impair the structure and function of the intervertebral disc (IVD), and cause low back pain. Recently, the piezo1 is recognized as a critical mechanically activated ion channel of IDD. Numerous studies have reported that the piezo1 ion channel was aberrantly activated in the degenerated disc tissues and deeply participated in the pathogenesis of IDD. Inactivating or interfering with the piezo1 channel could effectively prevent the progression of IDD under the experimental conditions. It may be a promising target for the prevention and treatment of the disabling disease. Therefore, we have to make a comprehensive investigation and understanding of the mechanisms and functions of the piezo1 in the biomechanics of the spine. This study mainly elucidates the role of the piezo1 channel in IDD, which may facilitate the development of therapeutic targets for this disease.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute muscular and cardiovascular responses to high load training with pre-exercise blood flow restriction","authors":"Enrique N. Moreno,&nbsp;William B. Hammert,&nbsp;Cole C. Martin,&nbsp;Samuel L. Buckner","doi":"10.1111/cpf.12799","DOIUrl":"10.1111/cpf.12799","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>The purpose of this study is to examine the acute muscular and cardiovascular responses to applying blood flow restriction (BFR) before high-load training.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty trained individuals visited the lab on three occasions. On Visit 1, participants completed paperwork and performed strength assessments. During Visits 2 and 3, participants completed four exercise conditions (one in each arm during each visit) as follows: (1) traditional resistance training (TRAD), (2) low load training with BFR (LLBFR), (3) low repetition high load training with pre-exercise BFR (PreBFR), and (4) low repetition traditional training (LRTRAD). Blood pressure, muscle thickness (MT), and isometric strength (ISO) were measured before and after exercise.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Data are displayed as means (SD). Immediately following exercise, MT in TRAD was greater compared with PreBFR (mean difference = 0.18[0.30] cm, <i>p</i> &lt; 0.001) and LRTRAD (mean difference = 0.28[0.30] cm, <i>p</i> &lt; 0.001). In addition, LLBFR demonstrated greater MT compared with PreBFR (mean difference = 0.24[0.30] cm, <i>p</i> &lt; 0.001]. Immediately following exercise, ISO was lower in TRAD compared with PreBFR (mean difference = 33.8[46.9]N, <i>p</i> &lt; 0.001) and the LRTRAD condition (mean difference = 32.8[50.4]N, <i>p</i> &lt; 0.001). In addition, ISO was lower in LLBFR compared with PreBFR (mean difference = 43.9 [47.4]N, <i>p</i> &lt; 0.001) and LRTRAD (mean difference = 42.9 [43.8]N, <i>p</i> &lt; 0.001). Immediately following exercise, systolic blood pressure was greater in TRAD compared with PreBFR and LRTRAD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The application of BFR before engaging in high-load training does not seem to augment the muscular responses to exercise when compared with traditional high loads alone; however, it may pose less demand on the cardiovascular system.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[18F]PSMA-1007 renal uptake parameters: Reproducibility and relationship to estimated glomerular filtration rate","authors":"Kristian Valind,&nbsp;Jonas Jögi,&nbsp;David Minarik,&nbsp;Elin Trägårdh","doi":"10.1111/cpf.12801","DOIUrl":"https://doi.org/10.1111/cpf.12801","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Scintigraphy with technetium-99m-labelled dimercaptosuccinic acid ([^99mTc]Tc-DMSA) is widely used for renal cortical imaging. Uptake of [^99mTc]Tc-DMSA has been shown to correlate with glomerular filtration rate (GFR). Prostate-specific membrane antigen (PSMA) radiopharmaceuticals used for positron emission tomography (PET) show high renal uptake and are being investigated for renal imaging. [⁶⁸Ga]Ga-PSMA-11 PET parameters have been shown to correlate with estimated GFR (eGFR). The aim of this study was to investigate the relationship between renal [¹⁸F]PSMA-1007 uptake and eGFR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Hundred and eighty-five patients underwent PET imaging at 1 and 2 h after injection of 4.0 ± 0.2 MBq [¹⁸F]PSMA-1007. Serum creatinine levels were measured and GFR estimated using the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations. Fifteen patients were excluded due to missing or incorrect data. Thus, data from 170 patients were analyzed. Kidneys were segmented in the PET images using a convolutional neural network with manual correction. For each kidney, mean standardized uptake value (SUV_mean) and segmentation volume in millilitres were measured. Linear regression analyses were performed with eGFR as the outcome variable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Variation in the eGFR values was explained to a significant degree by SUV_mean and renal segmentation volume in both the 1 and 2 h images. This correlation was stronger for CKD-EPI eGFR (1 h <i>R</i>² = 0.64; 2 h <i>R</i>² = 0.64) than for MDRD eGFR (1 h <i>R</i>² = 0.47; 2 h <i>R</i>² = 0.45).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Renal [¹⁸F]PSMA-1007 uptake parameters correlate with eGFR and are indicative of renal cortical function.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12801","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50151847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulmonary transit time has close relation with pulmonary pulse wave transit time in normal subjects","authors":"Jun Zhang,&nbsp;Xiao-Zhi Zheng,&nbsp;Xu-Chu Wu","doi":"10.1111/cpf.12794","DOIUrl":"10.1111/cpf.12794","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Pulmonary transit time (PTT) and pulmonary pulse wave transit time (pPTT) are useful parameters for the evaluation of cardiopulmonary circulation and vascular alterations, but their relationship remains unknown. The aim of this study was to investigate the correlation between PTT and pPTT.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 60 healthy volunteers were involved in this study. They were divided into two groups (30 participants per group): &lt;50 years and &gt;50 years. They all underwent Doppler echocardiography of pulmonary vein flow and contrast echocardiography with the measurement of pPTT and PTT, respectively. The correlation between PTT and pPTT was deduced.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared with Group of &lt;50 years, there was a significant increment in left atrial volume index, left atrial pressure and pulmonary artery stiffness but a significant reduction in acceleration times of pulmonary artery flow in Group of &gt;50 years (<i>p</i> &lt; 0.05). Group &gt;50 years had longer PTT and but reduced normalized PTT by R-R interval (NPTT), reduced normalized pPTT by R-R interval (NpPTT) than Group &lt;50 years (<i>p</i> &lt; 0.05), while there was no significant difference in pPTT between the two groups (<i>p</i> &gt; 0.05). PTT and NPTT were all negatively correlated with pPTT and NpPTT. The statistically significant strongest correlation was observed between PTT and NpPTT (<i>r</i> = −0.886, <i>p</i> &lt; 0.0001). The regression equation for them was <i>y</i> = 7.4396–13.095<i>x</i> (<i>R</i>² = 0.785; <i>p</i> &lt; 0.001), where x and y represent NpPTT and PTT, respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PTT had close relation with pPTT in normal subjects. From the regression equation for them, we can get the value of PTT simply and easily by non-invasively measured pPTT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9209505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment side affects exercising microvascular oxygenation response in active breast cancer survivors: A pilot study","authors":"Trent E. Cayot,&nbsp;Brooklyn Herbert,&nbsp;Riggs J. Klika","doi":"10.1111/cpf.12796","DOIUrl":"10.1111/cpf.12796","url":null,"abstract":"<p>Cancer treatment is associated with cardiovascular toxicity, skeletal muscle dysfunction and interruptions in mitochondrial respiration. Microvascular oxygenation responses, measured via near-infrared spectroscopy (NIRS), at peak exercise intensity has previously been associated with aerobic capacity. Specifically, the greater magnitude of microvascular deoxygenation observed at peak exercise intensity has been associated with higher aerobic capacity. Therefore, a pilot study investigated if diagnosis side (uninvolved side, treatment side) and/or exercise side (paddle side, non-paddle side) affected microvascular oxygenation responses at peak intensity during paddle exercise. Thirty-three breast cancer survivors (age = 57 ± 9 years, height = 1.64 ± 0.05 m, weight = 76.5 ± 15.6 kg, 7 ± 7 years since treatment) who also competed as dragon boat racers performed a unilateral (paddle), discontinuous graded exercise test (2-min exercise, 1-min rest) on a rowing ergometer to volitional fatigue. Tissue oxygenation saturation (StO_2DIFF) and total haemoglobin concentration (total[heme]_DIFF) responses at peak exercise intensity were measured bilaterally from the posterior deltoids using NIRS. Two-way analysis of variance determined if diagnosis side and/or exercise side effected StO_2DIFF or total[heme]_DIFF. Diagnosis side elicited a moderate effect (effect size = 0.66) on StO_2DIFF, as the treatment side deoxygenated less (−6.0 ± 14.7 ∆BSL) compared to the uninvolved side (−16.9 ± 16.9 ∆BSL) at peak exercise intensity. No other significant main effects or interactions were observed for StO_2DIFF or total[heme]_DIFF. The pilot findings suggest that the ability of the exercising muscle to use oxygen for the purpose of mitochondrial oxidative respiration may be impaired on the treatment side.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9225137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An evaluation of data processing when using the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with cerebral palsy","authors":"Trille Jakobsson,&nbsp;Katarina Lauruschkus,&nbsp;Åsa B. Tornberg","doi":"10.1111/cpf.12795","DOIUrl":"10.1111/cpf.12795","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To evaluate vertical acceleration, vector magnitude, non-wear time, valid day classifications, and valid period classifications in the data processing phase when using the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with cerebral palsy (CP).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Accelerometer data retrieved from 33 non-ambulant children and adolescents (4–17 years) with CP were analysed. Comparisons of (i) vertical acceleration versus vector magnitude, (ii) two different non-wear times, (iii) three different settings to classify a day as valid and (iv) two different settings to classify a period as valid were made.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results and Conclusions</h3>\u0000 \u0000 <p>Vector magnitude and a non-wear time of at least 90 consecutive minutes statistically significantly increased minutes recorded per day, especially for sedentary time. There was a statistically significant difference in numbers of valid days depending on time criteria set to determine a valid day, whereas there was no statistically significant difference in valid periods using 3 compared to 4 days. This study suggests using the pre-settings in ActiLife; vector magnitude, non-wear time of 90 consecutive minutes, 500 min recorded per day with periods of at least 3 valid days when assessing physical activity objectively by the ActiGraph GT3X accelerometer in non-ambulant children and adolescents with CP.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12795","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of blood flow restricted electrical stimulations on recovery from muscle damage","authors":"LaNiece J. Brown,&nbsp;Alexa N. Gasser,&nbsp;Robert L. Sterner,&nbsp;Scott J. Dankel","doi":"10.1111/cpf.12797","DOIUrl":"10.1111/cpf.12797","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Both electrical stimulations (E-STIM) and blood flow restriction (BFR) have been shown to treat symptoms of exercise-induced muscle damage, but little is known about their combined effects which was the purpose of this study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Individuals completed one set of eccentric elbow flexion exercises to induce muscle damage. Forty-eight hours later, E-STIM was applied using an interferential current administered to both arms for 20 min; however, only one arm completed the E-STIM protocol while also undergoing repeated bouts of BFR (full occlusion for 2 min separated by a 1-min rest intervals). Discomfort and isometric strength were assessed immediately before the damaging exercise, immediately before the treatments, and 0, 10, and 30 min posttreatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 22 individuals (11 females) completed the study. There were no interactions with respect to discomfort (BF₁₀ = 0.008) or isometric strength (BF₁₀ = 0.009) indicating that the addition of BFR did not alter the effectiveness of E-STIM. There was a main effect of time indicating that the damaging exercise was successful at depressing torque (pre: 284 N, post: 199 N; BF₁₀ = 2.70e9) and inducing discomfort (pre: 0 au, post: 6.4 au; BF₁₀ = 3.21e17). While isometric strength did not recover with the E-STIM treatments, discomfort was reduced at each the immediate post (5.3 au; BF₁₀ = 56 294) 10-min post (5.0 au; BF₁₀ = 46 163), and 30-min post (4.9 au; BF₁₀ = 707 600) time points.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>E-STIM may be useful for treating discomfort, but does not appear capable of recovering strength associated with muscle damage. The efficacy of E-STIM would not appear to be enhanced if performed under BFR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10657991","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Common carotid segmentation in 18F-sodium fluoride PET/CT scans: Head-to-head comparison of artificial intelligence-based and manual method","authors":"Reza Piri,&nbsp;Yaran Hamakan,&nbsp;Ask Vang,&nbsp;Lars Edenbrandt,&nbsp;Måns Larsson,&nbsp;Olof Enqvist,&nbsp;Oke Gerke,&nbsp;Poul Flemming Høilund-Carlsen","doi":"10.1111/cpf.12793","DOIUrl":"https://doi.org/10.1111/cpf.12793","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Carotid atherosclerosis is a major cause of stroke, traditionally diagnosed late. Positron emission tomography/computed tomography (PET/CT) with ¹⁸F-sodium fluoride (NaF) detects arterial wall micro-calcification long before macro-calcification becomes detectable by ultrasound, CT or magnetic resonance imaging. However, manual PET/CT processing is time-consuming and requires experience. We compared a convolutional neural network (CNN) approach with manual segmentation of the common carotids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Segmentation in NaF-PET/CT scans of 29 healthy volunteers and 20 angina pectoris patients were compared for segmented volume (Vol) and mean, maximal, and total standardized uptake values (SUVmean, SUVmax, and SUVtotal). SUVmean was the average of SUVmeans within the VOI, SUVmax the highest SUV in all voxels in the VOI, and SUVtotal the SUVmean multiplied by the Vol of the VOI. Intra and Interobserver variability with manual segmentation was examined in 25 randomly selected scans.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Bias for Vol, SUVmean, SUVmax, and SUVtotal were 1.33 ± 2.06, −0.01 ± 0.05, 0.09 ± 0.48, and 1.18 ± 1.99 in the left and 1.89 ± 1.5, −0.07 ± 0.12, 0.05 ± 0.47, and 1.61 ± 1.47, respectively, in the right common carotid artery. Manual segmentation lasted typically 20 min versus 1 min with the CNN-based approach. Mean Vol deviation at repeat manual segmentation was 14% and 27% in left and right common carotids.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>CNN-based segmentation was much faster and provided SUVmean values virtually identical to manually obtained ones, suggesting CNN-based analysis as a promising substitute of slow and cumbersome manual processing.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":null,"pages":null},"PeriodicalIF":1.8,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12793","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50121007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}