Clinical Physiology and Functional Imaging最新文献

{"title":"Cardiopulmonary exercise testing to indicate increased ventilatory variability in subjects with dysfunctional breathing","authors":"Nathalia B. S. Mendes,&nbsp;Franciele Plachi,&nbsp;Amanda Guimarães,&nbsp;Talmir Nolasco,&nbsp;Ricardo Gass,&nbsp;Marcelo Nogueira,&nbsp;Paulo J. Z. Teixeira,&nbsp;Marcelo B. Gazzana,&nbsp;J Alberto Neder,&nbsp;Danilo C. Berton","doi":"10.1111/cpf.12820","DOIUrl":"10.1111/cpf.12820","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Dysfunctional breathing (DB) is a common, but largely underappreciated, cause of chronic dyspnoea. Under visual inspection, most subjects with DB present with larger sequential changes in ventilation (V̇E) and breathing pattern (tidal volume (VT) and breathing frequency (<i>f</i>)) before and/or during incremental cardiopulmonary exercise testing (CPET). Currently, however, there are no objective criteria to indicate increased ventilatory variability in these subjects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty chronically dyspnoeic subjects with DB and 10 age- and sex-matched controls performed CPET on a cycle ergometer. Cut-offs to indicate increased V̇E, VT, <i>f</i>, and <i>f</i>/VT ratio variability (Δ = highest-lowest 20 s arithmetic mean) over the last resting minute (_rest), the 2^sd min of unloaded exercise (_unload), and the 3rd min of loaded exercise (_load) were established by ROC curve analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Subjects with DB presented with increased V̇E, higher ventilatory variability, higher dyspnoea burden, and lower exercise capacity compared to controls (<i>p</i> &lt; 0.05). ΔV̇E_load (&gt;4.1 L/min), Δ<i>f</i>_rest (&gt;5 breaths/min; bpm), Δ<i>f</i>_unload (&gt;4 bpm), Δ<i>f</i>_load (&gt;5 bpm), Δ<i>f</i>/VT_rest (&gt;4.9 bpm/L), and Δ<i>f</i>/VT_load (&gt;1.3 bpm/L) differentiated DB from a normal pattern (areas under the curve ranging from 0.729 to 0.845). High Δ<i>f</i>, in particular, was associated with DB across all CPET phases.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This study provides objective criteria to indicate increased ventilatory variability during incremental CPET in dyspnoeic subjects with DB. Large variability in breathing frequency seems particularly useful in this context, a finding that should be prospectively confirmed in larger studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 5","pages":"305-312"},"PeriodicalIF":1.8,"publicationDate":"2023-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10305636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiparametric magnetic resonance imaging: A robust tool to test pathogenesis and pathophysiology behind nephropathy in humans","authors":"Ulrik B. Andersen,&nbsp;Bryan Haddock,&nbsp;Ali Asmar","doi":"10.1111/cpf.12818","DOIUrl":"10.1111/cpf.12818","url":null,"abstract":"<p>Chronic kidney disease (CKD) is a major population disease. In diabetes as well as hypertension, kidney disease is one of the most serious complications. Recent research has demonstrated that chronic hypoxia is a key actor in the pathogenesis of CKD. In this review, we focus on how functional magnetic resonance imaging (fMRI) techniques can shed light on pathogenetic mechanisms and monitor new treatments aimed at preventing or ameliorating the disease. Multiparametric MRI techniques can measure changes in renal artery flow, tissue perfusion, and oxygenation repetitively over short time periods, enabling high time resolution. Furthermore, renal fibrosis can be quantified noninvasively by MRI diffusion tensor imaging, and techniques are upcoming to measure renal oxygen consumption. These techniques are all radiation and contrast-free.</p><p>We briefly present data, demonstrating that fMRI techniques can play a major role in future research in CKD, and possibly also in daily clinical practice.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"207-210"},"PeriodicalIF":1.8,"publicationDate":"2023-03-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12818","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9943206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lactate and ammonia measurements during cardiopulmonary exercise testing and its recovery phase—Consideration of age and sex in its interpretation","authors":"Nadja Ratia,&nbsp;Hanna Lantto,&nbsp;Emmi Rotgers,&nbsp;Vesa-Petteri Kouri,&nbsp;Mari Auranen,&nbsp;Ritva Luukkonen,&nbsp;Päivi Piirilä","doi":"10.1111/cpf.12817","DOIUrl":"10.1111/cpf.12817","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cardiopulmonary exercise testing with lactate and ammonia samples is used in the diagnostics of metabolic myopathies. As the effect of age and sex on the exercise lactate and ammonia levels are incompletely characterized for clinical associations, our aim was to assess the effects of these factors on healthy subjects to improve the test's interpretation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventy-three subjects (34 men and 39 women; age &lt; 35 years, <i>n</i> = 26, 35–50 years, <i>n</i> = 23 and &gt;50 years, <i>n</i> = 24) performed cardiopulmonary exercise tests with venous blood gases, plasma lactate and ammonia analyses at rest, during exercise, and 2, 4, 6, 10, 20 and 30 min into recovery.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The lactate (<i>p</i> = 0.021–0.044) and ammonia values (<i>p</i> = 0.002–0.038) differed between men and women measured during recovery and between three age groups point-by-point in maximal exercise and the recovery phase and also longitudinally, most notably between &lt;35- and &gt;50-year-groups (lactate <i>p</i> = &lt;0.001–0.040, ammonia <i>p</i> = 0.002–0.03). In the linear model, the yearly reduction of lactate was maximally −0.119 mmol/L and that of ammonia −1.514 µmol/L. The yearly reduction of lactate was greater in women than in men (−0.131 vs.−0.099 2 min into recovery), but for ammonia, the results were not as clear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Plasma lactate and ammonia concentrations measured during cardiopulmonary exercise were lower in older age groups, and their yearly reduction was also influenced by sex. These data give new information on lactate and ammonia levels and the effect of aging on them during exercise and recovery and may help assess cardiopulmonary exercise testing results.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"278-290"},"PeriodicalIF":1.8,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569279","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increasing circulating levels of Tenascin C in response to the Wingate anaerobic test","authors":"Ola Ekström,&nbsp;Kristoffer Ström,&nbsp;Bilal Ahmad Mir,&nbsp;Esa Laurila,&nbsp;Ylva Wessman,&nbsp;Mikko Lehtovirta,&nbsp;Karl-Fredrik Eriksson,&nbsp;Ola Hansson","doi":"10.1111/cpf.12816","DOIUrl":"10.1111/cpf.12816","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>Tenascin C (TNC) is a large extracellular matrix glycoprotein. It is involved in development and upregulated both during tissue repair and in several pathological conditions, including cardiovascular disease. Extracellular matrix proteins play a role in promoting exercise responses, leading to adaptation, regeneration, and repair. The main goal of this study was to investigate whether a short anaerobic effort leads to increased levels of TNC in serum.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Thirty-nine healthy men performed a Wingate test followed by a muscle biopsy. Myoblasts were isolated from the muscle biopsies and differentiated to myotubes ex vivo. TNC RNA was quantified in the biopsies, myotubes and myoblasts using RNA sequencing. Blood samples were drawn before and 5 min after the Wingate test. Serum TNC levels were measured using enzyme-linked immunosorbent assay.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After the Wingate test, serum TNC increased on average by 23% [15–33], median [interquartile range]; <i>P</i>_Wilcoxon &lt; 0.0001. This increase is correlated with peak power output and power drop, but not with VO_2max. TNC RNA expression is higher in myoblasts and myotubes compared to skeletal muscle tissue.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>TNC is secreted systemically as a response to the Wingate anaerobic test in healthy males. The response was positively correlated with peak power and power drop, but not with VO_2max which implicates a relation to mechanical strain and/or blood flow. With higher expression in undifferentiated myoblast cells than muscle tissue, it is likely that TNC plays a role in muscle tissue remodelling in humans. Our findings open for research on how TNC contributes to exercise adaptation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"271-277"},"PeriodicalIF":1.8,"publicationDate":"2023-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12816","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9569276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of adjuvant radiotherapy on skin biophysical properties in patients with breast cancer at risk for breast lymphedema: A prospective study","authors":"Alper Tuğral,&nbsp;Murat Akyol,&nbsp;Yeşim Bakar","doi":"10.1111/cpf.12815","DOIUrl":"10.1111/cpf.12815","url":null,"abstract":"<p>Breast cancer (BC) is the most common type of cancer among women. Radiotherapy (RT) is one of the main and primary treatment options for BC, especially in breast-conserving surgery (BCS). BC patients who underwent RT experience a wide range of symptoms, in which breast oedema and irritation of the skin take the lion's share. Breast oedema/lymphedema, which is also a prominent side effect after RT should be well determined in earlier settings due to the chronicity of lymphedema. Therefore, this study aimed to analyze the biophysical parameters of skin on the ipsilateral (IL) and contralateral (CL) sites via Tissue dielectric constant (TDC) and Transepidermal water loss (TEWL) methods in terms of oedema and skin barrier function (SBF). The following reference points before and after the RT were measured: (R1: Pectoralis muscle, R2: Upper breast, R3: Lower breast, R4: Lateral site of the thorax). A total of 24 BC patients (mean age and BMI: 52.78 ± 9.85 years and 28.42 ± 5.64 kg/m²) were evaluated. In the IL site, the SBF was not found significant in R1-R3, whereas significantly lower SBF was observed in R4 after RT (<i>t</i> = −3.361, <i>p</i> = 0.003). A significant increase in TDC was observed in R2 at the 5.0 mm depth (<i>t</i> = −2.500, <i>p</i> = 0.02). We suggest that a longer period of follow-up should be carefully carried out to track changes in terms of SBF and oedema in the irradiated breast. The increased need for early detection of changes associated with breast lymphedema can be achievable via noninvasive, safe, cheap, and easily repeatable devices.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"263-270"},"PeriodicalIF":1.8,"publicationDate":"2023-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9925863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in cardiac function in Navy divers during four days of successive dives in very cold diving conditions","authors":"Richard Lundell,&nbsp;Vesa Järvinen,&nbsp;Harri Mäkitalo,&nbsp;Kai Parkkola,&nbsp;Tomi Wuorimaa","doi":"10.1111/cpf.12814","DOIUrl":"10.1111/cpf.12814","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction and Methods</h3>\u0000 \u0000 <p>There is limited knowledge of cumulative effect of repetitive cold-water diving on cardiac function. Single cold dives cause some known cardiological risks, such as malign arrhythmia, due to a concurrent activation of the sympathetic and parasympathetic autonomic nervous system. A previous study from warmer water dives has shown that successive dives cause a decrease in vagal tone and a less responsive cardiovascular system. The aim of this study was to evaluate changes in cardiac function with 2D echocardiography during 4 days of diving in near-freezing water.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Left ventricle systolic function measures did not show any uniform changes. E/A ratio seemed to decrease successively with the number of dives. The diastolic tissue velocity of relaxing basal septum (e′) showed a decreasing trend as well. Diastolic blood pressure seemed to increase from predive (mean: 83 RR mmHg) to postdive values (mean: 87 RR mmHg) (p=NS). Heart rate decreased significantly from predive (mean: 71 bpm, range: 56–103) to postdive values (mean: 60 bpm, range: 37–88) (<i>p</i> &lt; 0.03).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Discussion and Conclusions</h3>\u0000 \u0000 <p>The study was conducted in very cold condition and with limited number of divers. Results of this preliminary study suggested a decreasing trend in left ventricular diastolic function in successive cold dives. Cumulative changes in cardiac function may cause health risks that need to be considered during cold water diving operations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"291-296"},"PeriodicalIF":1.8,"publicationDate":"2023-02-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9561766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Responses to exercise in systemic sclerosis-associated interstitial lung disease","authors":"Ronan P. Donnelly,&nbsp;Anita E. Smyth,&nbsp;Charles Mullan,&nbsp;Marshall S. Riley,&nbsp;D. Paul Nicholls","doi":"10.1111/cpf.12813","DOIUrl":"10.1111/cpf.12813","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pulmonary complications in systemic sclerosis (SSc) significantly increase morbidity and mortality. Our aim was to determine the factors limiting exercise capacity in SSc patients with and without interstitial lung disease (ILD), and to identify and quantify abnormalities during exercise that might assist in clinical assessment of this complication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen patients with SSc and ILD (SSc-ILD) were compared with 10 patients with SSc without ILD and 9 age- and sex-matched normal volunteers. Subjects performed symptom-limited incremental treadmill exercise with online measurement of respiratory gas exchange, arterial blood gas sampling and measurement of neurohormones in venous blood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with SSc-ILD had lower exercise capacity than SSc patients without ILD or normal subjects (peak oxygen consumption (PV̇O₂) (17.1 [4.2] vs. 22.0 [4.7] and 23.0 [5.4] ml kg⁻¹ min⁻¹, respectively, mean [SD], <i>p</i> &lt; 0.01 ANOVA), but PV̇O₂ did not correlate with static pulmonary function measurements. Ventilatory equivalent for CO₂ (V̇E/V̇CO₂; nadir) was higher in SSc-ILD patients than the other two groups (36.6 [8.0] vs. 29.9 [4.4] and 30.0 [2.5], <i>p</i> &lt; 0.005) as were peak exercise dead-space tidal volume ratio (0.44 [0.06] vs. 0.26 [0.09] and 0.26 [0.05], <i>p</i> &lt; 0.001) and peak exercise alveolar–arterial difference (28.9 [16.9] vs. 18.8 [14.0] and 11.5 [6.9] mmHg, <i>p</i> &lt; 0.05). Atrial natriuretic peptide was elevated in both SSc patient groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SSc-ILD results in lower exercise capacity than SSc without ILD, and abnormalities of gas exchange are seen. The possible use of cardiopulmonary exercise testing to identify disease and quantify impairment in SSc-ILD merits further study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"253-262"},"PeriodicalIF":1.8,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does muscle growth mediate changes in a nonspecific strength task?","authors":"Robert W. Spitz,&nbsp;Scott J. Dankel,&nbsp;Matthew B. Jessee,&nbsp;Vickie Wong,&nbsp;Zachary W. Bell,&nbsp;Takashi Abe,&nbsp;Jeremy P. Loenneke","doi":"10.1111/cpf.12810","DOIUrl":"10.1111/cpf.12810","url":null,"abstract":"<p>The purpose of this study was to determine if muscle growth mediates increases in a strength task which was not directly trained. One hundred fifty-one participants were randomized into control, one-repetition maximum training (1RM-TRAIN), or traditional training (TRAD-TRAIN). Training groups performed isotonic elbow flexion 3x/week for 6 weeks. Anterior muscle thickness at 50%, 60% and 70% upper arm length, and maximal isokinetic torque at 60°/sec were assessed pre- and post-training. Change-score mediation models (adjusted for sex, pre-muscle thickness, and pre-strength) were constructed for each muscle thickness site. The effects of each training group were evaluated relative to the control. Data is presented as coefficient (95% CI). There were no significant relative direct effects on nonspecific strength for either training group outside of the 60% model (1.7 [0.13, 3.27] Nm). The relative effect of 1RM-TRAIN on muscle thickness was greater in 60% (0.09 [0.01, 0.17] cm) and 70% (0.09 [0.00, 0.17] cm) models; while TRAD-TRAIN was greater in all three: (50% = 0.24 [0.15, 0.32]; 60% = 0.24 [0.16, 0.33]; 70% = 0.22 [0.14, 0.31] cm). The effect of muscle thickness on nonspecific strength was only significant for the 60% (−3.06 [−5.7, −0.35] Nm) model. The relative indirect effect on nonspecific strength was not significant for the 1RM-TRAIN or TRAD-TRAIN. Similar to previous findings on specific strength, we did not find evidence for a mediating effect of muscle growth on training induced increases in nonspecific strength. The importance of muscle growth for changes in nonspecifically trained strength may need to be reconsidered.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"223-231"},"PeriodicalIF":1.8,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9925823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is postexercise hypotension a method-dependent phenomenon in chronic stroke? A crossover randomized controlled trial","authors":"Guilherme F. Fonseca,&nbsp;André C. Michalski,&nbsp;Arthur S. Ferreira,&nbsp;Victor A. B. Costa,&nbsp;Renato Massaferri,&nbsp;Paulo Farinatti,&nbsp;Felipe A. Cunha","doi":"10.1111/cpf.12812","DOIUrl":"10.1111/cpf.12812","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study assessed the reproducibility of postexercise hypotension (PEH) detection after two bouts of mixed circuit training (MCT) using three approaches that accounts the pre-exercise values and/or a control session (CTL) to calculate PEH [i.e., (&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;A&lt;/mi&gt;\u0000 \u0000 &lt;mn&gt;1&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 \u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;exercise&lt;/mtext&gt;\u0000 \u0000 &lt;mo&gt;−&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;pre&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;exercise&lt;/mtext&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt; ${A}_{1}=text{post}{rm{ mbox{-} }}text{exercise}-text{pre}{rm{ mbox{-} }}text{exercise}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;); &lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mo&gt;(&lt;/mo&gt;\u0000 \u0000 &lt;msub&gt;\u0000 &lt;mi&gt;A&lt;/mi&gt;\u0000 \u0000 &lt;mn&gt;2&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 \u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;exercise&lt;/mtext&gt;\u0000 \u0000 &lt;mo&gt;−&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;CTL&lt;/mtext&gt;\u0000 \u0000 &lt;mo&gt;)&lt;/mo&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt; $({A}_{2}=text{post}{rm{ mbox{-} }}text{exercise}-text{post}{rm{ mbox{-} }}text{CTL})$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;; &lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;A&lt;/mi&gt;\u0000 \u0000 &lt;mn&gt;3&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 \u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 \u0000 &lt;mrow&gt;\u0000 &lt;mo&gt;(&lt;/mo&gt;\u0000 \u0000 &lt;mrow&gt;\u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 ","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"242-252"},"PeriodicalIF":1.8,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced progression of carotid intima media thickness by personalised pictorial presentation of subclinical atherosclerosis in VIPVIZA—A randomised controlled trial","authors":"Emma Nyman,&nbsp;Christer Grönlund,&nbsp;Davide Vanoli,&nbsp;Per Liv,&nbsp;Margareta Norberg,&nbsp;Anna Bengtsson,&nbsp;Patrik Wennberg,&nbsp;Per Wester,&nbsp;Ulf Näslund,&nbsp;for the VIPVIZA trial group","doi":"10.1111/cpf.12811","DOIUrl":"10.1111/cpf.12811","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Reduced progression of atherosclerosis can decrease the risk of cardiovascular disease (CVD). This study aimed at evaluating the effect of a pictorial intervention showing atherosclerotic severity on the progression of carotid atherosclerosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective randomised open-label blinded end-point trial with participants aged 40–60 years enroled from a routine CVD prevention programme. The intervention group (<i>n</i>: 1575) and their treating physicians received an image based presentation of subclinical atherosclerotic severity measured by carotid ultrasound. The control group (<i>n</i>: 1579) did not receive any information about ultrasound results. Carotid ultrasound at baseline and at 3-year follow-up contained plaque detection and measurements of carotid intima media thickness (cIMT). The left, right and bilateral-mean-cIMT, plaque prevalence and total plaque area (TPA) at 3-year follow-up were compared between groups. Significance level was set to <i>p</i> = 0.01 to adjust for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The intervention group revealed reduced cIMT progression in the left-mean-cIMT of −0.011 mm (<i>p</i> = 0.001) compared with the control group. The intervention effect on cIMT progression was most prominent in individuals with increased cIMT and plaque prevalence at baseline (−0.021 mm, <i>p</i> = 0.005). There were no differences in progression between groups for the right-and bilateral-mean-cIMT (−0.005 mm, <i>p</i> = 0.223 and −0.005 mm, <i>p</i> = 0.036, respectively), nor any differences between groups for plaque prevalence or TPA (odds ratio 0.88, <i>p</i> = 0.09 and 0.89, <i>p</i> = 0.21, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pictorial presentation of subclinical atherosclerotic severity sent to both the individual and their treating physician resulted in significantly reduced left cIMT progression. Pictorial presentation has the potential to increase adherence in CVD prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"232-241"},"PeriodicalIF":1.8,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9942186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}