Clinical Physiology and Functional Imaging最新文献

{"title":"Responses to exercise in systemic sclerosis-associated interstitial lung disease","authors":"Ronan P. Donnelly,&nbsp;Anita E. Smyth,&nbsp;Charles Mullan,&nbsp;Marshall S. Riley,&nbsp;D. Paul Nicholls","doi":"10.1111/cpf.12813","DOIUrl":"10.1111/cpf.12813","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Pulmonary complications in systemic sclerosis (SSc) significantly increase morbidity and mortality. Our aim was to determine the factors limiting exercise capacity in SSc patients with and without interstitial lung disease (ILD), and to identify and quantify abnormalities during exercise that might assist in clinical assessment of this complication.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifteen patients with SSc and ILD (SSc-ILD) were compared with 10 patients with SSc without ILD and 9 age- and sex-matched normal volunteers. Subjects performed symptom-limited incremental treadmill exercise with online measurement of respiratory gas exchange, arterial blood gas sampling and measurement of neurohormones in venous blood.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients with SSc-ILD had lower exercise capacity than SSc patients without ILD or normal subjects (peak oxygen consumption (PV̇O₂) (17.1 [4.2] vs. 22.0 [4.7] and 23.0 [5.4] ml kg⁻¹ min⁻¹, respectively, mean [SD], <i>p</i> &lt; 0.01 ANOVA), but PV̇O₂ did not correlate with static pulmonary function measurements. Ventilatory equivalent for CO₂ (V̇E/V̇CO₂; nadir) was higher in SSc-ILD patients than the other two groups (36.6 [8.0] vs. 29.9 [4.4] and 30.0 [2.5], <i>p</i> &lt; 0.005) as were peak exercise dead-space tidal volume ratio (0.44 [0.06] vs. 0.26 [0.09] and 0.26 [0.05], <i>p</i> &lt; 0.001) and peak exercise alveolar–arterial difference (28.9 [16.9] vs. 18.8 [14.0] and 11.5 [6.9] mmHg, <i>p</i> &lt; 0.05). Atrial natriuretic peptide was elevated in both SSc patient groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>SSc-ILD results in lower exercise capacity than SSc without ILD, and abnormalities of gas exchange are seen. The possible use of cardiopulmonary exercise testing to identify disease and quantify impairment in SSc-ILD merits further study.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"253-262"},"PeriodicalIF":1.8,"publicationDate":"2023-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does muscle growth mediate changes in a nonspecific strength task?","authors":"Robert W. Spitz,&nbsp;Scott J. Dankel,&nbsp;Matthew B. Jessee,&nbsp;Vickie Wong,&nbsp;Zachary W. Bell,&nbsp;Takashi Abe,&nbsp;Jeremy P. Loenneke","doi":"10.1111/cpf.12810","DOIUrl":"10.1111/cpf.12810","url":null,"abstract":"<p>The purpose of this study was to determine if muscle growth mediates increases in a strength task which was not directly trained. One hundred fifty-one participants were randomized into control, one-repetition maximum training (1RM-TRAIN), or traditional training (TRAD-TRAIN). Training groups performed isotonic elbow flexion 3x/week for 6 weeks. Anterior muscle thickness at 50%, 60% and 70% upper arm length, and maximal isokinetic torque at 60°/sec were assessed pre- and post-training. Change-score mediation models (adjusted for sex, pre-muscle thickness, and pre-strength) were constructed for each muscle thickness site. The effects of each training group were evaluated relative to the control. Data is presented as coefficient (95% CI). There were no significant relative direct effects on nonspecific strength for either training group outside of the 60% model (1.7 [0.13, 3.27] Nm). The relative effect of 1RM-TRAIN on muscle thickness was greater in 60% (0.09 [0.01, 0.17] cm) and 70% (0.09 [0.00, 0.17] cm) models; while TRAD-TRAIN was greater in all three: (50% = 0.24 [0.15, 0.32]; 60% = 0.24 [0.16, 0.33]; 70% = 0.22 [0.14, 0.31] cm). The effect of muscle thickness on nonspecific strength was only significant for the 60% (−3.06 [−5.7, −0.35] Nm) model. The relative indirect effect on nonspecific strength was not significant for the 1RM-TRAIN or TRAD-TRAIN. Similar to previous findings on specific strength, we did not find evidence for a mediating effect of muscle growth on training induced increases in nonspecific strength. The importance of muscle growth for changes in nonspecifically trained strength may need to be reconsidered.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"223-231"},"PeriodicalIF":1.8,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9925823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is postexercise hypotension a method-dependent phenomenon in chronic stroke? A crossover randomized controlled trial","authors":"Guilherme F. Fonseca,&nbsp;André C. Michalski,&nbsp;Arthur S. Ferreira,&nbsp;Victor A. B. Costa,&nbsp;Renato Massaferri,&nbsp;Paulo Farinatti,&nbsp;Felipe A. Cunha","doi":"10.1111/cpf.12812","DOIUrl":"10.1111/cpf.12812","url":null,"abstract":"&lt;div&gt;\u0000 \u0000 \u0000 &lt;section&gt;\u0000 \u0000 &lt;h3&gt; Background&lt;/h3&gt;\u0000 \u0000 &lt;p&gt;This study assessed the reproducibility of postexercise hypotension (PEH) detection after two bouts of mixed circuit training (MCT) using three approaches that accounts the pre-exercise values and/or a control session (CTL) to calculate PEH [i.e., (&lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;A&lt;/mi&gt;\u0000 \u0000 &lt;mn&gt;1&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 \u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;exercise&lt;/mtext&gt;\u0000 \u0000 &lt;mo&gt;−&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;pre&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;exercise&lt;/mtext&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt; ${A}_{1}=text{post}{rm{ mbox{-} }}text{exercise}-text{pre}{rm{ mbox{-} }}text{exercise}$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;); &lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;mo&gt;(&lt;/mo&gt;\u0000 \u0000 &lt;msub&gt;\u0000 &lt;mi&gt;A&lt;/mi&gt;\u0000 \u0000 &lt;mn&gt;2&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 \u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;exercise&lt;/mtext&gt;\u0000 \u0000 &lt;mo&gt;−&lt;/mo&gt;\u0000 \u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 \u0000 &lt;mtext&gt;CTL&lt;/mtext&gt;\u0000 \u0000 &lt;mo&gt;)&lt;/mo&gt;\u0000 &lt;/mrow&gt;\u0000 &lt;annotation&gt; $({A}_{2}=text{post}{rm{ mbox{-} }}text{exercise}-text{post}{rm{ mbox{-} }}text{CTL})$&lt;/annotation&gt;\u0000 &lt;/semantics&gt;&lt;/math&gt;; &lt;math&gt;\u0000 &lt;semantics&gt;\u0000 &lt;mrow&gt;\u0000 &lt;msub&gt;\u0000 &lt;mi&gt;A&lt;/mi&gt;\u0000 \u0000 &lt;mn&gt;3&lt;/mn&gt;\u0000 &lt;/msub&gt;\u0000 \u0000 &lt;mo&gt;=&lt;/mo&gt;\u0000 \u0000 &lt;mrow&gt;\u0000 &lt;mo&gt;(&lt;/mo&gt;\u0000 \u0000 &lt;mrow&gt;\u0000 &lt;mtext&gt;post&lt;/mtext&gt;\u0000 \u0000 &lt;mi&gt;-&lt;/mi&gt;\u0000 ","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"242-252"},"PeriodicalIF":1.8,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9573931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduced progression of carotid intima media thickness by personalised pictorial presentation of subclinical atherosclerosis in VIPVIZA—A randomised controlled trial","authors":"Emma Nyman,&nbsp;Christer Grönlund,&nbsp;Davide Vanoli,&nbsp;Per Liv,&nbsp;Margareta Norberg,&nbsp;Anna Bengtsson,&nbsp;Patrik Wennberg,&nbsp;Per Wester,&nbsp;Ulf Näslund,&nbsp;for the VIPVIZA trial group","doi":"10.1111/cpf.12811","DOIUrl":"10.1111/cpf.12811","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Reduced progression of atherosclerosis can decrease the risk of cardiovascular disease (CVD). This study aimed at evaluating the effect of a pictorial intervention showing atherosclerotic severity on the progression of carotid atherosclerosis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A prospective randomised open-label blinded end-point trial with participants aged 40–60 years enroled from a routine CVD prevention programme. The intervention group (<i>n</i>: 1575) and their treating physicians received an image based presentation of subclinical atherosclerotic severity measured by carotid ultrasound. The control group (<i>n</i>: 1579) did not receive any information about ultrasound results. Carotid ultrasound at baseline and at 3-year follow-up contained plaque detection and measurements of carotid intima media thickness (cIMT). The left, right and bilateral-mean-cIMT, plaque prevalence and total plaque area (TPA) at 3-year follow-up were compared between groups. Significance level was set to <i>p</i> = 0.01 to adjust for multiple comparisons.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The intervention group revealed reduced cIMT progression in the left-mean-cIMT of −0.011 mm (<i>p</i> = 0.001) compared with the control group. The intervention effect on cIMT progression was most prominent in individuals with increased cIMT and plaque prevalence at baseline (−0.021 mm, <i>p</i> = 0.005). There were no differences in progression between groups for the right-and bilateral-mean-cIMT (−0.005 mm, <i>p</i> = 0.223 and −0.005 mm, <i>p</i> = 0.036, respectively), nor any differences between groups for plaque prevalence or TPA (odds ratio 0.88, <i>p</i> = 0.09 and 0.89, <i>p</i> = 0.21, respectively).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Pictorial presentation of subclinical atherosclerotic severity sent to both the individual and their treating physician resulted in significantly reduced left cIMT progression. Pictorial presentation has the potential to increase adherence in CVD prevention.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 4","pages":"232-241"},"PeriodicalIF":1.8,"publicationDate":"2023-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12811","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9942186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Issue Information","authors":"","doi":"10.1002/ski2.126","DOIUrl":"https://doi.org/10.1002/ski2.126","url":null,"abstract":"","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":" ","pages":""},"PeriodicalIF":1.8,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49294649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary study of changes in carotid artery elasticity in type 2 diabetes mellitus","authors":"Chun-xiang Jin,&nbsp;Jing Tian,&nbsp;Hui-hui Yang,&nbsp;Yu He","doi":"10.1111/cpf.12808","DOIUrl":"10.1111/cpf.12808","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in <i>diabetic patients with or without microvascular complications</i> using velocity vector imaging (VVI) analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>CCA elasticity measured by VVI decreased significantly between three groups (<i>p</i> &lt; 0.05), while FMD decreased significantly only in cDM group (<i>p</i> &lt; 0.01) and only IMT in cDM group was significantly thicker than that of Control group (<i>p</i> &lt; 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (<i>p</i> &lt; 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |<i>r</i> | &lt;0.8, <i>p</i> &lt; 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |<i>r</i> | &lt;0.5, <i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Compared with FMD, CCA elasticity measured by VVI showed more <i>obvious</i> changes in diabetic patients <i>with different levels of vascular damage</i> and may be considered as <i>an alternative</i> indicator in evaluating arterial status of T2DM.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 3","pages":"181-191"},"PeriodicalIF":1.8,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9245376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantifying leg muscle deoxygenation during incremental cycling in hypoxemic patients with fibrotic interstitial lung disease","authors":"Mathieu Marillier,&nbsp;Anne-Catherine Bernard,&nbsp;Samuel Verges,&nbsp;Onofre Moran-Mendoza,&nbsp;J. Alberto Neder","doi":"10.1111/cpf.12809","DOIUrl":"10.1111/cpf.12809","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hypoxaemia and cardiocirculatory abnormalities may impair muscle oxygen (O₂) delivery relative to O₂ requirements thereby increasing the rate of O₂ extraction during incremental exercise in fibrotic interstitial lung disease (<i>f</i>-ILD). Using changes in deoxyhaemoglobin concentration ([HHb]) by near-infrared spectroscopy (NIRS) as a proxy of O₂ extraction, we investigated whether a simplified (double-linear) approach, previously tested in heart failure, would provide useful estimates of muscle deoxygenation in <i>f</i>-ILD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 25 patients (23 men, 72 ± 8 years; 20 with idiopathic pulmonary fibrosis, lung diffusing capacity for carbon monoxide = 44 ± 11% predicted) and 12 age- and sex-matched healthy controls performed incremental cycling to symptom limitation. Changes in vastus lateralis [HHb] assessed by NIRS were analysed in relation to work rate (WR) and O₂ uptake throughout the exercise.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Patients showed lower exercise capacity than controls (e.g., peak WR = 67 ± 18% vs. 105 ± 20% predicted, respectively; <i>p</i> &lt; 0.001). The [HHb] response profile was typically S-shaped, presenting three distinct phases. Exacerbated muscle deoxygenation in patients versus controls was evidenced by: (i) a steeper mid-exercise [HHb]-WR slope (0.30 ± 0.22 vs. 0.11 ± 0.08 μmol/W; <i>p</i> = 0.008) (Phase 2), and (ii) a larger late-exercise increase in [HHb] (<i>p</i> = 0.002) (Phase 3). Steeper [HHb]-WR slope was associated with lower peak WR (<i>r</i> = –0.70) and greater leg discomfort (<i>r</i> = 0.77; <i>p</i> &lt; 0.001) in <i>f</i>-ILD.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This practical approach to interpreting [HHb] during incremental exercise might prove useful to determine the severity of muscle deoxygenation and the potential effects of interventions thereof in hypoxemic patients with <i>f</i>-ILD.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 3","pages":"192-200"},"PeriodicalIF":1.8,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9260413","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and feasibility of cardiopulmonary exercise testing in head and neck cancer survivors","authors":"Adrian W. Midgley,&nbsp;Andrew R. Levy,&nbsp;Felipe A. Cunha,&nbsp;Angela Key,&nbsp;Joanne M. Patterson,&nbsp;Simon N. Rogers","doi":"10.1111/cpf.12807","DOIUrl":"10.1111/cpf.12807","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Assess safety and feasibility of the cardiopulmonary exercise test (CPET) for evaluating head and neck cancer (HaNC) survivors. Also compare their cardiorespiratory fitness to age and sex-matched norms and establish current physical activity levels.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty HaNC survivors [29 male; mean (<i>SD</i>) age, 62 (8) years], who had completed treatment up to 1 year previously, were recruited. Participants performed a CPET on a cycle ergometer to symptom-limited tolerance. Participants completed a questionnaire to report contributory factors they perceived as influencing test termination. Physical activity levels were determined using a self-reported physical activity questionnaire.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Three participants did not complete the CPET because (1) poor fitting mouthpiece and naso-oral mask due to facial disfiguration from surgery; (2) knee pain elicited by cycling; and (3) early CPET termination due to electrocardiogram artefacts. Participants reached a mean peak oxygen uptake that was 34% lower than predicted and the mean (<i>SD</i>) CPET duration of 7:52 (2:29) min:s was significantly lower than the target test duration of 10 min (<i>p</i> &lt; 0.001). Leg muscle aches and/or breathing discomfort were major contributory factors influencing test termination for 78% of participants, compared to 13% for dry mouth/throat and/or drainage in the mouth/throat. No major adverse events occurred. Participants were categorised as 26% active, 8% moderately active, and 66% insufficiently active.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These preliminary data suggest the CPET appears safe and feasible for most HaNC survivors when strict exclusion criteria are applied; however, low levels of cardiorespiratory fitness should be considered when calculating an appropriate ramp rate.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 3","pages":"170-180"},"PeriodicalIF":1.8,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12807","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Left atrial contraction strain during a Valsalva manoeuvre: A study in healthy humans","authors":"Peter Gottfridsson,&nbsp;Lucy Law,&nbsp;Roman A'roch,&nbsp;Tomi Myrberg,&nbsp;Magnus Hultin,&nbsp;Per Lindqvist,&nbsp;Michael Haney","doi":"10.1111/cpf.12806","DOIUrl":"10.1111/cpf.12806","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Cardiac mechanics are influenced by loading conditions as well as sympathetic tone. Left atrial (LA) contractile function assessed by two-dimensional (2D) strain has been described in the setting of controlled preload alterations; however, studies show conflicting findings about change or direction of change. We hypothesized that the controlled preload reduction and the sympathetic nervous system activation that occurs during a standardized Valsalva manoeuvre would bring about a change in LA contraction strain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Healthy young adults of both sexes were recruited. Transthoracic echocardiographic ultrasound images were collected before and during a Valsalva manoeuvre. Standard imaging windows for LA strain assessment were used and the images were copied and stored for later offline analysis. These were assessed for adequate atrial wall visualization in 2D strain assessment. Paired comparisons were carried out using Student's <i>T</i> test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Thirty-eight participants were included and there were 22 complete studies with paired pre- and during Valsalva manoeuvre. LA contraction strain at baseline was 10.5 ± 2.8% (standard deviation) and during the Valsalva manoeuvre 10.6 ± 4.6%, <i>p</i> = 0.86.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The Valsalva manoeuvre, a combination of preload reduction and sympathetic nervous system activation, seems not to be associated with a change in LA contraction strain in healthy young individuals. LA contraction strain should be interpreted in the context of both atrial loading conditions and prevailing autonomic nervous system activity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 3","pages":"165-169"},"PeriodicalIF":1.8,"publicationDate":"2022-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.12806","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9613794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility and early effects of bed-cycling eccentric training: Potential clinical applications","authors":"Laura Pavlin,&nbsp;Florian Fernandez,&nbsp;Rauhiti Lowgreen,&nbsp;Isabelle Ohresser,&nbsp;Jean-Paul Cristol,&nbsp;Cécile Turc-Baron,&nbsp;Henri Bernardi,&nbsp;Robin Candau","doi":"10.1111/cpf.12805","DOIUrl":"10.1111/cpf.12805","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to evaluate feasibility and early effects of moderate intensity bed-cycling eccentric training on healthy individuals, and establish whether this training modality could be implemented into bedridden patients' routine care.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Longitudinal study with prepost exercise intervention measurements. The development of a bed-adapted eccentric ergometer allowed to conduct five training sessions during 3 weeks at increasing intensity on 11 healthy individuals. Force-speed relationship, maximal voluntary knee extension force and neural activation of subjects were evaluated before and after the programme.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Five training sessions were sufficient to decrease the rate of perceived exertion whereas eccentric power output increased (+40%). After training, maximal voluntary isometric contraction force measured during knee extension had significantly improved in all subjects, with a mean increase of 17%. Maximal cycling power was also significantly higher (+7%) after the training programme.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Taken together, these results show that moderate load eccentric bed cycling (i) was feasible and efficient, (ii) did not generate excessive individual perception of effort during exercise nor develop major muscular or joint pain after training and (iii) allowed early force and power gains in healthy subjects.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 3","pages":"154-164"},"PeriodicalIF":1.8,"publicationDate":"2022-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9244697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}