{"title":"2型糖尿病患者颈动脉弹性变化的初步研究","authors":"Chun-xiang Jin, Jing Tian, Hui-hui Yang, Yu He","doi":"10.1111/cpf.12808","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in <i>diabetic patients with or without microvascular complications</i> using velocity vector imaging (VVI) analysis.</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>CCA elasticity measured by VVI decreased significantly between three groups (<i>p</i> < 0.05), while FMD decreased significantly only in cDM group (<i>p</i> < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (<i>p</i> < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (<i>p</i> < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |<i>r</i> | <0.8, <i>p</i> < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |<i>r</i> | <0.5, <i>p</i> < 0.05).</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Compared with FMD, CCA elasticity measured by VVI showed more <i>obvious</i> changes in diabetic patients <i>with different levels of vascular damage</i> and may be considered as <i>an alternative</i> indicator in evaluating arterial status of T2DM.</p>\n </section>\n </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"43 3","pages":"181-191"},"PeriodicalIF":1.3000,"publicationDate":"2022-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A preliminary study of changes in carotid artery elasticity in type 2 diabetes mellitus\",\"authors\":\"Chun-xiang Jin, Jing Tian, Hui-hui Yang, Yu He\",\"doi\":\"10.1111/cpf.12808\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in <i>diabetic patients with or without microvascular complications</i> using velocity vector imaging (VVI) analysis.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>CCA elasticity measured by VVI decreased significantly between three groups (<i>p</i> < 0.05), while FMD decreased significantly only in cDM group (<i>p</i> < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (<i>p</i> < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (<i>p</i> < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |<i>r</i> | <0.8, <i>p</i> < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |<i>r</i> | <0.5, <i>p</i> < 0.05).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Compared with FMD, CCA elasticity measured by VVI showed more <i>obvious</i> changes in diabetic patients <i>with different levels of vascular damage</i> and may be considered as <i>an alternative</i> indicator in evaluating arterial status of T2DM.</p>\\n </section>\\n </div>\",\"PeriodicalId\":10504,\"journal\":{\"name\":\"Clinical Physiology and Functional Imaging\",\"volume\":\"43 3\",\"pages\":\"181-191\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2022-12-30\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Clinical Physiology and Functional Imaging\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12808\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"PHYSIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Clinical Physiology and Functional Imaging","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/cpf.12808","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
A preliminary study of changes in carotid artery elasticity in type 2 diabetes mellitus
Background
Carotid stiffening is found to be present in patients with type 2 diabetes mellitus (T2DM) together with endothelial dysfunction and it remains unclear about the role of carotid elasticity in the development of diabetic vascular damage. The aim of the study was to investigate changes and significance of carotid artery elasticity in diabetic patients with or without microvascular complications using velocity vector imaging (VVI) analysis.
Methods
Fifty participants were enrolled and divided into health Control group, the uncomplicated DM (uDM) group and the complicated DM (cDM) group. All of them underwent carotid ultrasound examinations. VVI was used to evaluate the common carotid artery (CCA) elasticity and intima-media thickness (IMT) was also measured. Flow-mediated dilation (FMD) was performed to detect the vascular endothelial function. Then differences and correlations of variables between three groups were compared and analyzed.
Results
CCA elasticity measured by VVI decreased significantly between three groups (p < 0.05), while FMD decreased significantly only in cDM group (p < 0.01) and only IMT in cDM group was significantly thicker than that of Control group (p < 0.05). Representative VVI variables were independently, negatively related to the known duration and microalbuminuria (p < 0.05). All VVI variables were significantly correlated with FMD (0.5 ≤ |r | <0.8, p < 0.001), and just a small part of VVI variables were significantly correlated with IMT (0.3 ≤ |r | <0.5, p < 0.05).
Conclusion
Compared with FMD, CCA elasticity measured by VVI showed more obvious changes in diabetic patients with different levels of vascular damage and may be considered as an alternative indicator in evaluating arterial status of T2DM.
期刊介绍：
Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest.
Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.
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