Clinical Physiology and Functional Imaging最新文献

{"title":"Mechanical interactions between the biceps femoris long and short heads: Implications for T-junction hamstring injuries","authors":"Gakuto Nakao,&nbsp;Ginji Nara,&nbsp;Risa Adachi,&nbsp;Koki Ishiyama,&nbsp;Kazuyoshi Kozawa,&nbsp;Keita Sekiguchi,&nbsp;Kanna Nagaishi,&nbsp;Kousuke Shiwaku,&nbsp;Norio Hayashi,&nbsp;Jurdan Mendiguchia,&nbsp;Raki Kawama,&nbsp;Nobuhiro Aoki,&nbsp;Masaki Katayose,&nbsp;Keigo Taniguchi","doi":"10.1111/cpf.70026","DOIUrl":"https://doi.org/10.1111/cpf.70026","url":null,"abstract":"<p>Although force transfer during elongation occurs longitudinally and transversely, the influence of transverse force transfer between the biceps femoris long head and short head remains unclear. This study aimed to investigate whether separating the intermuscular connections between the biceps femoris long head and short head alters tension in the biceps femoris long head. Eight human cadaver legs were used, and ultrasonic shear wave elastography measurements were performed under four conditions: (1) intact, (2) removal of all tissues from the skin to the deep fascia, (3) intermuscular dissection, and (4) biceps femoris short head detachment. Measurements were taken in four limb positions, defined by hip and knee joint angles, under each tissue condition. The shear modulus of the biceps femoris long head significantly increased by 62.2% after intermuscular dissection compared to fascia removal, and further increased by 174.7% after biceps femoris short head detachment. In contrast, the shear modulus of the biceps femoris short head significantly decreased by 36.0% following intermuscular dissection and by 75.1% after detachment. In conclusion, reducing biceps femoris short head tension while increasing biceps femoris long head tension may influence muscle stress distribution, particularly during movement.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144914961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin perfusion pressure, distal blood pressure vs. trans cutaneous oxygen pressure for predicting wound healing after major amputation","authors":"J. P. Paludan,&nbsp;C. Høyer,&nbsp;A. Høgh,&nbsp;H. D. Zacho","doi":"10.1111/cpf.70025","DOIUrl":"https://doi.org/10.1111/cpf.70025","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare measurements of skin perfusion pressure (SPP) and transcutaneous oxygen pressure (TcPO₂) to predict postamputation wound healing according to amputation level.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This study was conducted as a prospective two-centre, head-to-head study.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-two patients had SPP, TcPO₂ measured (below and above the knee), and toe and ankle blood pressure measurements taken before major amputation. Paired measurements of SPP and TcPO₂ were used to compare the methods. We found overall poor agreement between SPP and TcPO₂ measurements, with crude agreement below the knee in 32 of 45 limbs (71%) and above the knee in 17 of 23 limbs (74%), with κ values of 0.32 and 0.13, respectively. Among the 29 patients whose SPP measurements below the knee indicated healing potential, seven were amputated above the knee. Blood pressure measurements above the cut-off values (30 mmHg for the toe and 80 mmHg for the ankle, above 40 mmHg SPP and TcPO₂ values), were seen as an indicator of high healing potential.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>We found poor (71%–74%) crude agreement between SPP and TcPO₂, concerning measurements above and below the knee, using the established diagnostic cut-offs for predicting a high probability of postamputation wound healing. We determined that SPP and TcPO₂ evaluate different physiological properties of the microcirculation and cannot be interchanged. Additionally, we found that the actual amputation level is often chosen at another level than that suggested by SPP and TcPO₂, indicating that the choice is based on a multitude of factors, including clinical, paraclinical and patient-related parameters.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70025","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144869483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adherence to health-related fitness tests in working-aged adults—who are we (not) measuring?","authors":"Olli-Pekka Nuuttila,&nbsp;Pauliina Husu,&nbsp;Kari Tokola,&nbsp;Henri Vähä-Ypyä,&nbsp;Tommi Vasankari,&nbsp;Harri Sievänen","doi":"10.1111/cpf.70020","DOIUrl":"https://doi.org/10.1111/cpf.70020","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>This study aimed to examine the adherence to selected health-related fitness (HRF) tests in adults. In addition, we investigated how excluded participants or those who did not attend HRF tests differed in their background characteristics from those who attended.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Two population study samples comprising 3867 (1594 males) 20─69-year-old participants performing HRF tests, or 1249 (456 males) participants answering only the study questionnaire, were pooled for the analyses. The selected HRF tests were: one-leg stand, neck-shoulder mobility, jump-and-reach, modified push-ups, and 6-min walking test. The exclusion rate was analyzed separately for each test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In total, 14.9% of the participants were excluded from at least one test. Failure to meet the health criteria and unwillingness to perform the test were the most typical reasons for the exclusion. The exclusion rate was highest in the modified push-up test (13.2%), while in all other tests, the rate was less than 5%. Excluded participants were more likely (<i>p</i> &lt; 0.001) older (46–69 years) (OR = 4.59), not meeting physical activity recommendations for endurance (OR = 2.28) and perceiving their health (OR = 3.69) and fitness (OR = 3.26) as poor. Similarly, participants who answered only the questionnaire were more likely (<i>p</i> &lt; 0.01) to perceive their health (OR = 1.56) and fitness (OR = 1.41) as poor and not meeting physical activity recommendations for endurance (OR = 1.48).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The assessed HRF tests were feasible in terms of low exclusion rates. Individuals that were excluded or not participating the tests differed in their background characteristics from those who attended highlighting the importance of feasible testing methods to achieve a representative population sample of participants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-08-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144764150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term blood pressure variability and predictability of dynamic cerebral autoregulation in acute stroke patients","authors":"Lehel-Barna Lakatos,&nbsp;Martin Müller,&nbsp;Laura Weichsel,&nbsp;Mareike Österreich,&nbsp;Manuel Bolognese","doi":"10.1111/cpf.70024","DOIUrl":"https://doi.org/10.1111/cpf.70024","url":null,"abstract":"<p>Blood pressure (BP) management in acute ischaemic stroke presents uncertainties regarding whether systolic BP (sys), mean BP (mean), or diastolic BP (dia) should be used for therapeutic guidance. Repeated assessments of BP-dependent cerebral autoregulation (CA) could help identify a suitable BP modality for this purpose. Forty-nine patients (median age 75 [62–81] years; 13 women) with unilateral acute ischemic stroke (NIHSS 5 [1.75–15.0]), underwent stroke center care and dynamic cerebral autoregulation (dCA) assessments on days 1 to 3 after the stroke event. Using frequency-dependent transfer function analysis between BP and cerebral blood flow velocity (CBFV), gain indicates the amplitude transmission, and phase shift represents the phase difference between the two. CA failure is typically indicated by a low or absent phase shift in the very low (0.02–0.07 Hz) or low frequencies (0.07–0.20 Hz) ranges, leading to a direct transmission of BP changes to CBFV changes. BP values were averaged, with their standard deviation indicating BP variability (BPV). Averaged sys, mean, or dia BP did not predict gain or phase, but BPV did. In the stroke-affected hemisphere (AH), sys, mean and dia BPV on day 1 predicted low frequency gain on days 1 and 2 (<i>p</i> &lt; 0.02 - <i>p</i> &lt; 0.001). On day 2, dia more than mean BPV predicted linearly (<i>p</i> &lt; 0.001) very low frequency phase with small phase values associated with a low BPV and large phase values with high BPV values. In acute stroke, dia BPV predicts best phase shift, and could be a promising candidate for BP guidance.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing the effects of voluntary and electrically induced contractions on muscle recovery and vascular function","authors":"Patrick M. Tomko,&nbsp;Edward Z. Pelka,&nbsp;B. Ryan Davis,&nbsp;Sydney F. Gallagher,&nbsp;John McDaniel","doi":"10.1111/cpf.70023","DOIUrl":"https://doi.org/10.1111/cpf.70023","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>While both voluntary (VOL) and electrically stimulated (ES) contractions increase blood flow, ES induces greater oxidative stress, raising the risk of exercise induced muscle damage (EIMD), which can impair vascular function, and oxygen utilization.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>We examined how ES and force-matched VOL contractions impact microvascular function and muscle oxidative capacity.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>Utilizing a cross-over design, 16 healthy adults performed 40 isometric knee extensions (KE) via ES and VOL contractions. The following variables were assessed at baseline, 1 h, 24 h, and 48 h postexercise: knee extensor strength and soreness, microvascular function (hyperemic response to single passive leg movement (sPLM), and skeletal muscle oxidative capacity (SMOC) of the vastus lateralis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Result</h3>\u0000 \u0000 <p>Maximal voluntary contraction (MVC) was lower following ES than VOL at 24 h (324.7 ± 125.8 vs. 366.8 ± 125.6 N, <i>p</i> = 0.01) and 48 h (308.5 ± 124.7 vs. 379.0 ± 129.0 N, <i>p</i> = 0.001). Soreness (<i>p</i> ≤ 0.02) and muscle swelling (<i>p</i> ≤ 0.02) were greater after ES. Vascular function, quantified as the AUC for total hyperemic response following sPLM and measured by Doppler/ultrasound, was reduced following ES at 1 h (<i>p</i> = 0.01) and 24 h (<i>p</i> = 0.002). SMOC was more impaired after ES than VOL (<i>p</i> ≤ 0.03). There was a 31% decrease in oxygen recovery rate 1-h post-ES, with an additional 10% decline at 24-h and 48-h (<i>p</i> ≤ 0.03) compared to VOL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>ES seemed to elicit EIMD, resulting in reduced MVC, impaired recovery, while affecting microvascular function and oxidative capacity.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144716471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age differences and reliability of the skeletal muscle quality measurements in women and their relationship with cardiovascular risk","authors":"Olavo João Frederico Ramos Junior,&nbsp;Vivian dos Santos Pinheiro,&nbsp;Thiago Silveira Alvares","doi":"10.1111/cpf.70021","DOIUrl":"https://doi.org/10.1111/cpf.70021","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Muscle quality is well-known to decrease with aging and is a risk factor for metabolic abnormalities. However, the impact of muscle quality decline among aging women and its association with cardiovascular risk remains unclear. Thus, this study aimed to compare muscular outcomes and investigate whether a correlation exists between muscle quality and cardiovascular risk factors in women. The reliability of muscle quality measurements in young and older women was also addressed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Forty-eight participants were recruited for the study, including 24 young adults (24 ± 4 years) and 24 older women (66 ± 5 years) were submitted to the evaluation of muscle echo intensity (EI - an indicator of morphological muscle quality) using ultrasound, muscle strength, hemodynamic measurements (systolic and diastolic blood pressure), cardiovascular risk biomarkers, and cardiovascular risk tools (Framingham score and vascular age).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Muscle strength and both functional and morphological muscle quality were greater (<i>p</i> &lt; 0.05) in young women compared to older women. Functional muscle quality was inversely associated with systolic and diastolic blood pressure, while muscle EI was positively associated with fasting glucose levels. All muscle strength and muscle quality measurements demonstrated very good test-retest reliability (ICC ≥ 0.98) and low coefficients of variation (&lt;1.5%).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that muscle strength and quality differ by age group and are associated with specific cardiovascular risk markers in women. Ultrasound-derived assessments of muscle quality appear to be highly reliable across age groups and may serve as useful tools for research on muscle health and cardiometabolic risk.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144712069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DXA-based estimation of body volume in 4-compartment models: Validating and modifying the Smith-Ryan equation","authors":"Lee Doernte,&nbsp;April Spears,&nbsp;Michael Lane","doi":"10.1111/cpf.70022","DOIUrl":"https://doi.org/10.1111/cpf.70022","url":null,"abstract":"<p>Accurate body composition assessment is crucial for evaluating health and guiding interventions. Four-compartment (4 C) models, which separately quantify fat mass, lean body mass, bone mineral content and total body water, offer improved accuracy but usually require multiple devices. This study aimed to validate dual-energy X-ray absorptiometry (DXA)–derived body volume (BV) equations—specifically those from Wilson and Smith-Ryan—against air displacement plethysmography (ADP), and to modify the Smith-Ryan equation for enhanced BV estimates in a 4 C model. Ninety healthy adults (50 females, 40 males; aged 18–66 years; BMI 18–34 kg/m²) were recruited at a single-centre facility. Participants underwent DXA scanning (GE Lunar DXA) for tissue composition, ADP (Bod Pod) for BV, and bioelectrical impedance spectroscopy for total body water, with all measurements performed by trained technicians. BV was estimated using the original Wilson and Smith-Ryan equations and a regression-modified Smith-Ryan equation, and these estimates were incorporated into the 4 C model to calculate percent body fat (%BF) and fat mass (FM). All DXA-based BV estimates correlated highly with ADP (<i>r</i> ≥ 0.99). Although the original equations showed small, statistically significant differences in %BF and FM compared to ADP (<i>p</i> &lt; 0.05), the modified Smith-Ryan equation produced BV estimates equivalent to ADP (<i>p</i> = 0.998). These findings suggest that calibrated DXA-derived BV equations can reliably substitute for ADP in 4 C models, enhancing the accessibility and cost-effectiveness of body composition analysis. Future research should validate these findings in more diverse populations.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The value of the HFA-PEFF and H2FPEF scores in determining the phenotypes and comorbidity burden in heart failure with preserved ejection fraction","authors":"Selda Murat,&nbsp;Bektas Murat,&nbsp;Halit Emre Yalvac,&nbsp;Fatih Enes Durmaz,&nbsp;Duygu Inan,&nbsp;Ahmet Celik,&nbsp;Yuksel Cavusoglu","doi":"10.1111/cpf.70019","DOIUrl":"https://doi.org/10.1111/cpf.70019","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The HFA-PEFF and H2FPEF scores are widely used for diagnosing heart failure with preserved ejection fraction (HFpEF). However, HFpEF is a heterogeneous condition with multiple phenotypes influenced by comorbidities and etiologies.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate the performance and agreement of these scoring systems across different HFpEF phenotypes and identify additional echocardiographic and clinical parameters that may improve phenotyping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 194 HFpEF patients were classified into three phenotypes: (1) common metabolic group, (2) atrial fibrillation (AF)-predominant group, and (3) hypertension with left ventricular hypertrophy group. The clinical, laboratory, and echocardiographic characteristics of these phenotypes were analyzed. The agreement and performance between HFA-PEFF and H2FPEF scores for phenotypes in HFpEF patients were assessed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 194 HFpEF patients were included. While 92.3% of patients had a high HFA-PEFF score, only 42.8% had a high H2FPEF score. The agreement between these scoring methods was low across all phenotypes. Phenotype-specific differences were observed: interventricular septal thickness was highest in phenotype 3, systolic pulmonary artery pressure (SPAP) was highest in phenotype 2, and left atrial reservoir strain (LASr) and right ventricular free wall longitudinal strain (RV-FWLS) were lowest in phenotype 2.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The HFA-PEFF and H2FPEF scores showed limited agreement in distinguishing HFpEF phenotypes. Additional echocardiographic parameters such as IVS thickness, SPAP, LASr, and RV-FWLS may enhance phenotypic differentiation and improve HFpEF classification. A more refined diagnostic approach incorporating these parameters could guide personalized treatment strategies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144323701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of gender, age and method variations on contractility in extremity lymphatic collectors using indocyanine green fluorescence lymphangiography","authors":"Mads Fich Lønnee,&nbsp;Mads Radmer Jensen,&nbsp;Bryan Haddock,&nbsp;Lene Simonsen,&nbsp;Tonny Karlsmark,&nbsp;Jens Bülow","doi":"10.1111/cpf.70017","DOIUrl":"https://doi.org/10.1111/cpf.70017","url":null,"abstract":"<p>The objectives of this study were to examine how extremity lymphatic collector contraction frequency is influenced by gender, age, and methodological variations in indocyanine green (ICG) injection using near infrared fluorescence (NIRF) imaging in healthy adults. Ten women (19–46 years) and eight men (18–59 years) were examined with 30-min NIRF videos recorded at different time points 0–150 min after injection of ICG. Variations in ICG volume (0.1 mL vs. 0.3 mL), -concentration (1 mg/mL vs. 2.5 mg/mL), -injection site (hand vs. foot), -route of administration (subcutaneous vs. intradermal) were applied to all subjects. The primary outcome was mean contraction frequency with maximum contraction frequency and number of visualised extremity lymphatic collectors as secondary outcomes. The median of mean contraction frequencies for females and males were 0.42 min⁻¹ (IQR 0,19 min⁻¹) and 0.25 min⁻¹ (IQR 0,15 min⁻¹), respectively (<i>p</i> = 0.022). The median of maximum contraction frequencies for females and males were 0.70 min⁻¹ (IQR 0,26 min⁻¹) and 0.34 min⁻¹ (IQR 0,15 min⁻¹), respectively (<i>p</i> = 0.015). Neither age, method variations nor imaging delay had any significant effect on contraction frequencies. Number of visualised collectors increased slightly during 150 min (<i>p</i> = 0.02). Mean and maximum contraction frequencies were significantly higher in women compared to men. This is a novel finding that warrants verification in future studies. Contraction frequency measured with 30-min NIRF imaging using an ICG volume as little as 0.1 mL and a concentration of 1 mg/mL is seemingly robust and readily available. This method is recommendable for perturbation studies of lymphatic collector function and pathophysiology.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of [18F]PSMA-1007 uptake variability in patients with prostate cancer","authors":"Elin Trägårdh,&nbsp;Måns Larsson,&nbsp;David Minarik,&nbsp;Olof Enqvist,&nbsp;Lars Edenbrandt","doi":"10.1111/cpf.70016","DOIUrl":"https://doi.org/10.1111/cpf.70016","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>The biodistribution of PSMA-ligands is of interest in radionuclide therapy planning. We investigated the variability of [¹⁸F]PSMA-1007 uptake in organs at risk and in relation to tumour burden in prostate cancer patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A total of 1086 patients who underwent PSMA PET-CT for staging or recurrence of prostate cancer were included. Total lesion volume (TLV) and total lesion uptake (TLU) were calculated from manual segmentations. The mean standardized uptake value (SUV_mean) in the organs at risk kidneys, liver, parotid glands and spleen was obtained. Correlations between TLV/TLU and SUV_mean in normal tissues were calculated using Spearman rank correlation. SUV_mean in normal tissues was stratified into groups based on TLV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The median (IQR) SUV_mean of the kidneys, liver, parotid glands, and spleen was 13.1 (IQR 4.6), 11.8 (4.4), 18.6 (6.8) and 11.3 (5.8), respectively. The median TLV was 3.8 cm³ (9.7) and median TLU was 31.2 cm³ (106.3). There was no significant correlation between TLV or TLU and SUV_mean for the liver, parotid glands, or spleen, but a weak negative correlation between TLV/TLU and SUV_mean in the kidneys (<i>r</i> = −0.011, <i>p</i> = 0.0005; <i>r</i> = −0.09, <i>p</i> = 0.003). There was a tendency towards a lower SUV_mean in the kidneys and parotid glands in patients with a very high TLV.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>There was a large uptake variability in organs at risk, which demonstrates the need for individual pretherapy dosimetry. There may be a tumour sink effect in the kidneys and parotid glands in patients with a very high TLV.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 4","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70016","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144292862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}