Clinical Physiology and Functional Imaging最新文献

{"title":"Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrations","authors":"Michihiro Kon,&nbsp;Koichi Watanabe","doi":"10.1111/cpf.70036","DOIUrl":"10.1111/cpf.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals who engage in high-intensity endurance exercise reportedly have a lower rate of mortality from metabolic diseases than do those who engage in moderate-intensity endurance exercise. However, the mechanisms underlying this association remain unclear. The cytokines C1q/tumour necrosis factor-related protein (CTRP) 3, CTRP9, and follistatin-like 1 (FSTL1) improve metabolic diseases. The secretion of these circulating cytokines is enhanced through acute endurance exercise; however, the effects of exercise intensity on this secretion have not been elucidated. We investigated the effect of exercise intensity on the circulating CTRP3, CTRP9, and FSTL1 concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten healthy men performed three experimental trials—moderate-intensity cycling (MIE; 50% maximal oxygen uptake), high-intensity cycling (HIE; 75% maximal oxygen uptake), and control (Con; rest)—in a crossover design. The duration of the exercise trials was varied to match the total energy expenditure between the trials. Blood samples were collected before exercise and at 0 (immediately after exercise) and 120 min after exercise. Circulating CTRP3, CTRP9, and FSTL1 concentrations were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the HIE trial, significant increases in the circulating concentrations of CTRP3, CTRP9, and FSTL1 were observed after exercise compared to before exercise; however, no significant increases in these cytokines were observed in the MIE trial. Moreover, the increased ratios of the CTRP3, CTRP9, and FSTL concentrations after exercise compared to those before exercise were higher only in the HIE trial compared to the Con trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings indicate that circulating CTRP3, CTRP9, and FSTL1 concentrations are affected by exercise intensity during endurance exercise, increasing only after high-intensity exercise.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic assessment of peak atrial longitudinal strain in paroxysmal atrial fibrillation patients compared to age-matched controls","authors":"Larissa Bastos,&nbsp;Faris Al-Khalili,&nbsp;Magnus Bäck,&nbsp;Aristomenis Manouras,&nbsp;Johan Engdahl,&nbsp;Kambiz Shahgaldi","doi":"10.1111/cpf.70035","DOIUrl":"10.1111/cpf.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate left atrial (LA) function assessed by peak atrial longitudinal strain (PALS) in an elderly population with silent paroxysmal atrial fibrillation (PAF) compared to age-matched control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From the STROKESTOP2-study, patients with newly diagnosed silent PAF were enrolled together in a randomly selected age-matched control group. All patients had NT-proBNP levels between 125 and 900 ng/L. Echocardiographic examinations were performed and analyzed offline using dedicated software. In addition to conventional echocardiographic variables, PALS was measured using a two-dimensional speckle tracking (2D-ST) biplane.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study population (mean age 76 ± 0.3) demonstrated significantly reduced PALS in patients with PAF (<i>N</i> = 69) compared to controls (<i>N</i> = 94) (23.9% ± 6.5% vs 30.7% ± 7.6%, <i>p</i> &lt; 0.001). In the PAF group, 29 (42%) patients had normal LA volume index (LAVI) defined as <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <mo>≤</mo>\u0000 </mrow>\u0000 </mrow>\u0000 <annotation> $le $</annotation>\u0000 </semantics></math>34 mL/m². When subgroups with normal LAVI were compared, PALS was reduced in PAF compared to controls (25.1 ± 8.0 vs 31.1 ± 7.8, <i>p</i> = 0.001). NT-proBNP levels did not differ between the PAF group (median 228 ng/L) and the control group (median: 217 ng/L) (<i>p</i> = 0.16). In multiple linear regression analysis, left ventricular global longitudinal strain, stroke volume index and LAVI were independent predictors of PALS. Receiver operating characteristic curve identified PALS threshold &lt;22% for predicting risk of silent PAF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PALS was significantly reduced in PAF patients even in the absence of significant LA remodeling. PALS &lt;22% predicts risk for silent PAF in general elderly population. In high-risk patients PALS could be used for AF screening enrichment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12587354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145444084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of epicardial adiposity on STEMI outcomes: Insights from a prospective cohort","authors":"Ahmet Murat,&nbsp;Gürkan Karaca,&nbsp;Nijad Bakhshaliyev,&nbsp;Ahmet Ekmekci,&nbsp;Ali Kimiaei,&nbsp;Seyedehtina Safaei,&nbsp;Mehmet Eren","doi":"10.1111/cpf.70034","DOIUrl":"10.1111/cpf.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Cardiovascular diseases, primarily driven by atherosclerosis, remain the leading cause of death worldwide. Key risk factors include diabetes, hyperlipidemia, hypertension, smoking, genetic predispositions and notably, obesity-related visceral adipose tissue (VAT). Like VAT, epicardial adipose tissue (EAT) influences heart function by releasing inflammatory cytokines. This study evaluated the relationship between EAT thickness and coronary artery disease severity, its interaction with risk factors, and its prognostic value for major cardiac and cerebrovascular events in ST-segment elevation myocardial infarction (STEMI) patients after percutaneous intervention (PCI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 138 STEMI patients (124 males and 14 females) treated with primary PCI at our centre, documenting medical and demographic data, cardiovascular history, risk factors, time metrics, physical and clinical examinations, EAT thickness, and biochemical parameters. Follow-ups at 1 and 6 months post-discharge tracked major cardiovascular events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average age of the patients was 55.14 ± 12.83 years, predominantly male (89.9%), with varying prevalences of diabetes (22.5%), hypertension (38.4%), hyperlipidemia (37%), metabolic syndrome (32.6%), and family history of cardiovascular disease (47.1%). EAT thickness ranged from 1.5 to 11 mm, averaging 3.91 ± 1.42. Patients were divided into tertiles by EAT thickness, showing significant differences in age, weight, body mass index (BMI), thrombolysis in myocardial infarction (TIMI) scores, and number of affected vessels but not in mortality (7.2%), Major adverse cardiac and cerebrovascular events (MACCE) (13.8%), or combined endpoint outcomes across tertiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>No correlation was found between EAT thickness and mortality or MACCE in STEMI patients, highlighting the need for validation in long-term studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nuclear medicine in hematology: Bridging diagnostics and therapy","authors":"Julius Jungnitsch,&nbsp;Kirsten Korsholm,&nbsp;Fazila Asmar,&nbsp;Søren Møller","doi":"10.1111/cpf.70031","DOIUrl":"10.1111/cpf.70031","url":null,"abstract":"<p>The investigation and therapeutic trials of hematological and hemato-oncological diseases using nuclear medicine methods dates back to the 1930s. At that time, ³²P was used as the isotope for various experimental procedures. Over the years, a wide variety of isotopes and techniques have been developed, some of which have established themselves as the gold standard in certain clinical indications, such as in the management of patients with lymphoma. Other nuclear medicine procedures are used as complementary techniques in more specific clinical scenarios. In recent years, the concept of theranostics has gained popularity in nuclear medicine. Radioendotherapies have been developed and some of them have already been FDA approved. Their promising results could potentially have a major impact on the treatment of patients with hemato-oncologic diseases. In this article we review some of the contemporary techniques used in nuclear medicine and recent developments of clinical indications in the field of hematology and oncology.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145291367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of upper airway obstruction by diaphragm ultrasound combined with inspired volume measurement","authors":"Alain Boussuges,&nbsp;Manon Leveque,&nbsp;Ralph Haddad,&nbsp;Camille Martinez,&nbsp;Eric Nussbaum,&nbsp;Fabienne Brégeon","doi":"10.1111/cpf.70033","DOIUrl":"https://doi.org/10.1111/cpf.70033","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Upper airway stenosis may remain undiagnosed for extended periods. Ultrasound allows for the evaluation of the impact of respiratory diseases on diaphragmatic function.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Three patients presenting with symptoms suggestive of upper airway obstruction were assessed using diaphragmatic ultrasound. Simultaneously, inspired volumes were measured on a breath-by-breath basis. Inspiratory flow was calculated during both quiet and deep breathing by dividing inspired volume by excursion duration.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Diaphragmatic function, studied by the measurement of excursion and thickening fraction, was preserved in all cases. However, the temporal profile of diaphragmatic excursion differed from that observed in healthy individuals. A reduction in inspiratory flow was observed and appeared to be related to the severity of obstruction, as determined by clinical presentation and flow-volume loop analysis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Based on these preliminary findings, the combination of diaphragmatic ultrasound and inspired volume measurement should be able to provide valuable information in the assessment of upper airway stenosis. Further prospective studies are warranted to confirm its clinical utility.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145204799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deep learning-based 3D classification of head and neck cancer PET/MRI: Radiologist comparison and Grad-CAM interpretability","authors":"Joonas Liedes,&nbsp;Jussi Hirvonen,&nbsp;Oona Rainio,&nbsp;Sarita Murtojärvi,&nbsp;Simona Malaspina,&nbsp;Riku Klén,&nbsp;Jukka Kemppainen","doi":"10.1111/cpf.70030","DOIUrl":"10.1111/cpf.70030","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To develop and evaluate a three-dimensional convolutional neural network for automated classification of PET/MRI images in head and neck cancer (HNC) patients, assessing its performance against radiologist interpretation and its potential as a diagnostic aid.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Data from 202 patients with HNC who underwent ¹⁸F-FDG PET/MRI were used to train and validate PET-, MRI-, and PET/MRI-based models. Of these data, 101 patients were labelled as positive in terms of having HNC, and 101 patients as negative. An additional test set of 20 patients was also evaluated, where 10 patients were labelled as positive and 10 as negative. The model performance was assessed using sensitivity, specificity, accuracy, and AUC. Grad-CAM was utilised to improve interpretability and classification results on the test set were compared with a radiologist.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The PET-based model achieved an AUC of 0.92 on the test set, with an accuracy of 90%, a sensitivity of 100% and a specificity of 80%. PET/MRI and MRI-based models underperformed relative to the PET-based model. The radiologist achieved perfect classification accuracy. Analysis of Grad-CAM showed that the model classifications are based on real areas of interest. In addition, it gave valuable insight into using similar systems in identifying false positive findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The PET-based model demonstrated high sensitivity, indicating its potential as a pre-screening tool for HNC. However, specificity requires improvement to reduce false-positive rates. Enhanced datasets and refinement of model architecture will be crucial before clinical adoption. Grad-CAM provides valuable insights into model decisions, aiding clinical integration.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70030","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145136676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproducibility of diastolic function parameters in repeated ECG-gated SPECT myocardial perfusion imaging and echocardiography","authors":"Aaro Krohns,&nbsp;Tomi P. Laitinen,&nbsp;Tiina M. Laitinen,&nbsp;Saara Sillanmäki","doi":"10.1111/cpf.70032","DOIUrl":"10.1111/cpf.70032","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To study the reproducibility of diastolic function parameters from myocardial perfusion imaging (MPI) using ECG-gated single photon emission computed tomography (SPECT), and echocardiography in repeated imaging.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We studied the reproducibility of MPI diastolic function parameters peak-filling rate (PFR) and time to peak filling (TTPF) as well as echocardiographic parameters E/A, E/e', and E-wave deceleration time (DT). The study population consisted of 21 patients who underwent routine MPI with repeated rest acquisition and echocardiography. In a test–retest setting, appropriate diastolic measures were successfully obtained using SPECT in 20 patients, with E/A measured in 18, E/e' in 17, and DT in 16 patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>We found that PFR was well reproducible with the intraclass correlation coefficient (ICC) 0.887, and coefficient of variation (CV%) 10.5. However, TTPF was poorly reproducible (ICC 0.012, and CV% 17.5). E/A was highly reproducible (ICC 0.963, and CV% 12.5). Decent reproducibility was observed for E/e' (ICC 0.809, and CV% 18.6) and DT (ICC 0.833, and CV% 12.0). We further studied the correlation between these parameters. PFR (EDV/s) had negative correlation with DT (r = −0.538, <i>p</i> = 0.039) and E/A had positive with E/é (<i>r</i> = 0.689, <i>p</i> = 0.002). No other significant correlations were observed (<i>p</i> &gt; 0.05 for all). We also examined how parameters classified patients as normal or abnormal regarding the diastolic function. E/A and E/e´, as well as E/A and PFR showed similar classifications in 88% of cases, with a Kappa value of 0.433, <i>p</i> = 0.074 for both.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>PFR obtained from repeated SPECT studies, along with the E/A ratio, is highly reproducible.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145130352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hemodynamic and autonomic dysfunction in symptomatic carotid artery stenosis","authors":"Kristine Wichmann Madsen,&nbsp;Rasmus Primholdt Haahr,&nbsp;Tatevik Mkhitarjan,&nbsp;Niels Wiinberg,&nbsp;Jacob Rørbech Marstrand,&nbsp;Sverre Rosenbaum,&nbsp;Alexander Cuculiza Henriksen,&nbsp;Lisbeth Marner","doi":"10.1111/cpf.70029","DOIUrl":"https://doi.org/10.1111/cpf.70029","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Hemodynamic failure in patients with steno-occlusive arterial disease is a major risk factor for stroke. Previous studies have identified impaired autonomic function in patients with carotid artery stenosis. Our study explores autonomic dysfunction and altered cerebrovascular hemodynamics in patients with stenosis and suspected hemodynamic failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>To assess autonomic nervous system dysfunction, patients underwent heart rate variability (HRV) testing, an active stand test, and the Valsalva maneuver with simultaneous monitoring of heart rate, blood pressure, and cardiac output. Transcranial Doppler was used to measure relative changes in cerebral blood flow during Valsalva.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Analysis of 13 patients and 19 controls revealed a significantly greater decrease in cerebral blood flow in the patient group during Valsalva, as evidenced by mean relative changes in time-averaged peak velocities ±SE of 0.80 ± 0.04 in patients compared to 0.96 ± 0.05 in controls (<i>p</i> &lt; 0.05). There were no significant differences in mean arterial blood pressure or heart rate during the Valsalva maneuver. HRV analysis and the active stand test did not reveal autonomic dysfunction or orthostatic intolerance.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Patients with steno-occlusive carotid artery disease exhibit impaired intracranial flow during Valsalva-induced blood pressure reduction. However, our results do not support the presence of significant autonomic dysfunction in patients with symptomatic large-vessel cerebrovascular disease as measured by HRV and blood pressure reduction during active stand.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70029","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145102294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adolescent obesity and insulin resistance: The role of anthropometric indicators in metabolic health","authors":"Prasenjit Chaudhuri,&nbsp;Debanjana Sen,&nbsp;Jhuma Saha,&nbsp;Suparna Parua,&nbsp;Koushik Bhattacharya,&nbsp;Alak Kumar Syamal","doi":"10.1111/cpf.70028","DOIUrl":"https://doi.org/10.1111/cpf.70028","url":null,"abstract":"<p>The present study investigates the relationship between obesity and metabolic, hormonal, and clinical indicators in adolescent girls. A total of 75 girls aged 15–19 years (mean age: 17.53 ± 1.29 years) were enrolled, including 58 with excess weight or obesity and 17 with normal weight. Anthropometric parameters related to obesity, various clinical scores, fasting glucose, fasting insulin, insulin resistance indices, lipid profile, blood pressure, and thyroid-stimulating hormone (TSH) were assessed. Mann-Whitney U test compared differences between the groups, while Spearman's rho correlation analysed the associations among adiposity, metabolic, and clinical parameters. Simple linear regression predicted insulin resistance indices using BMI, WHR, and WHtR. Receiver operating characteristic (ROC) analysis evaluated the predictive ability of BMI, WHR, and WHtR for insulin resistance. Girls with obesity exhibited significantly higher weight, BMI, WC, WHR, and WHtR (<i>p</i> &lt; 0.05). Acanthosis scores and insulin resistance indices strongly correlated with BMI, WHR, and WHtR, while lipid profile parameters showed no significant association with adiposity. Regression analysis identified BMI and WHtR as strong predictors of HOMA-IR, while WHR and WHtR inversely correlated with QUICKI and GIR. The McAuley Index moderately correlated with BMI and WHtR. ROC analysis confirmed BMI (AUC = 0.779, <i>p</i> = 0.000) and WHtR (AUC = 0.776, <i>p</i> = 0.000) as strong predictors of insulin resistance. Concluding that, obesity in adolescent girls is strongly linked to insulin resistance but not lipid profile parameters. BMI and WHtR emerge as reliable predictors, with acanthosis as a potential clinical marker.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144998624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospectively synchronized time-resolved ventricular cine images from 2D real-time exercise cardiac magnetic resonance imaging","authors":"Julius Åkesson,&nbsp;Jonathan Edlund,&nbsp;Katarina Steding-Ehrenborg,&nbsp;Einar Heiberg","doi":"10.1111/cpf.70027","DOIUrl":"https://doi.org/10.1111/cpf.70027","url":null,"abstract":"<p>Breath-hold ECG-gated cardiovascular magnetic resonance (CMR) imaging is challenging during exercise due to motion, ECG-problems, and lengthy scans. To facilitate time-resolved volumetric measures from exercise-CMR, we aimed to develop a method for constructing time-resolved ventricular cines from real-time free-breathing exercise-CMR. Time-resolved ventricular cines were semi-automatically constructed from real-time exercise-CMR by identifying end-expiratory timeframes, identifying one R-R interval within these timeframes, and synchronizing R-R intervals across slice positions. To investigate utility, ECG-gated rest CMR and real-time exercise-CMR images were collected from ten healthy volunteers and ten heart failure patients. The consistency of the left ventricular mass (LVM) was assessed between rest and exercise at end diastole (ED), mid systole (MS), end systole (ES), and early rapid filling (ERF). When comparing LVM between rest and exercise for healthy volunteers, bias ± SD was 1.5 ± 2.7 g at ED, 0.9 ± 3.3 g at MS, 1.3 ± 3.3 g at ES, and 1.2 ± 3.3 g at ERF. When comparing LVM between rest and exercise for heart failure patients, bias ± SD was 1.6 ± 2.8 g at ED, 1.0 ± 2.7 g at MS, 1.5 ± 2.6 g at ES, and 1.6 ± 2.5 g at ERF. The bias ± SD between ED and ES in standard rest images was 0.0 ± 0.7 g for healthy volunteers, and 0.0 ± 0.5 g for heart failure patients. The method for constructing time-resolved ventricular cines from real-time exercise-CMR demonstrated utility for time-resolved volumetric measurements in healthy volunteers and heart failure patients.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 5","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/cpf.70027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144929906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}