Clinical Physiology and Functional Imaging最新文献

{"title":"Total peripheral resistance fine-tunes mean arterial pressure to a set level induced by isometric handgrip","authors":"Marek Żyliński,&nbsp;Wiktor Niewiadomski,&nbsp;Gerard Cybulski,&nbsp;Małgorzata Wojciechowska,&nbsp;Anna Gąsiorowska-Bień","doi":"10.1111/cpf.70044","DOIUrl":"10.1111/cpf.70044","url":null,"abstract":"<p>We quantified, using a new method, the contribution of heart rate (HR), stroke volume (SV) and total peripheral resistance (TPR) to the increase in mean arterial pressure (MAP), expressed as % of baseline during a 3-min static handgrip (HG) performed at 30% of maximum voluntary contraction by 11 subjects. Arterial pressure was measured noninvasively with Finapres Nova, SV with Doppler imaging. The increase in MAP was greater at the end of HG than at the end of the first minute of HG, the maximum individual increases in MAP ranged from 0% to 33%; the HR contribution was mostly positive, the SV contribution was mostly negative. The magnitude of the HR contribution was similar at the beginning and end of the HG both in subjects who experienced high and low MAP increases; a similar observation applies to the SV contribution. Only the TPR contribution was significantly correlated with the individual MAP increase. Assuming that the individual level of MAP is set during HG, the contribution of TPR by taking positive or negative values plays a main role as an adjustment factor that brings MAP to set level; compensating for insufficient or excessive contributions from HR and SV. Our results question the use of changes in MAP or TPR as an indicator of sympathetic reactivity; the increase in MAP is determined by the individual change in set level induced by HG, whereas the magnitude of the change in sympathetic activity is such as needed to achieve the desired increase in MAP.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145948638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra- and inter-observer reliability of ultrasound muscle thickness of gluteal and biceps femoris long head in individuals with and without SCI","authors":"Boas J. Wijker,&nbsp;Sonja de Groot,&nbsp;Britt Denneman,&nbsp;Puck Brouwer,&nbsp;Vasileios Tomaras,&nbsp;Annelaura Haarler,&nbsp;Guido Weide,&nbsp;Lidwine B. Mokkink,&nbsp;Johanna M. van Dongen,&nbsp;Thomas W. J. Janssen","doi":"10.1111/cpf.70045","DOIUrl":"10.1111/cpf.70045","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This study aimed to evaluate both inter- and intra-observer reliability of ultrasound-based muscle thickness measurements in able-bodied (AB) individuals, as well as intra-observer reliability in individuals with spinal cord injury (SCI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ultrasound measurements of the gluteus maximus, medius, minimus and biceps femoris long head were performed on 31 AB participants and 30 participants with SCI. Each AB participant was scanned on two occasions by three observers, with three repetitions per muscle per occasion. The muscle thickness in participants with SCI was measured using three repetitions during a single test occasion, conducted by one observer. A generalizability (G) study was conducted to assess the reliability of the measurements.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In AB participants, intra-observer reliability for gluteal muscles ranged from G-coefficient: 0.57 to 0.89, and for biceps femoris long head from G-coefficient: 0.60 to 0.76. Inter-observer reliability in AB participants was G-coefficient:0.48–0.72 for the gluteal muscles and G-coefficient: 0.52 for the biceps femoris. In contrast, intra-observer reliability in participants with SCI was excellent across all muscles (G-coefficient: 0.95–0.99).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Ultrasound can assess muscle thickness with moderate to good intra-observer reliability in AB participants, but with only poor to moderate inter-observer reliability. In contrast, intra-observer reliability was excellent in participants with SCI. Reliability depends on observer experience and varies across muscles and populations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12780933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145917226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Estimation of whole-body skeletal muscle volume using pectoralis muscle area and anthropometric measurements from chest CT in a Korean population","authors":"Kiook Baek,&nbsp;Soon Ho Yoon,&nbsp;Jung Hee Hong","doi":"10.1111/cpf.70046","DOIUrl":"10.1111/cpf.70046","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Skeletal muscle is a critical organ influencing prognosis and overall health; however, the direct measurements of muscle mass are not easily attainable. This study aimed to estimate whole-body skeletal muscle volume (WBM) using pectoralis muscle area (PMA) derived from a single chest-CT slice and basic anthropometric data in a Korean population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed PET-CT data from 201 adults (101 women, 100 men). WBM was segmented using deep learning–based software. The PMA was delineated and was divided into pectoralis major and minor. Sex-specific LASSO regression models were developed: Model 1 included total PMA, Model 2A pectoralis major, Model 2B pectoralis minor, and Model 2C both muscles as separate predictors while Model 3 was based on L3 muscle area for comparison. All models additionally included age, height, weight, and waist circumference.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In females and in males, R² values were 0.76 and 0.75 (Model 1), 0.77 and 0.76 (Model 2C), and 0.84 and 0.81 (Model 3), respectively. Bland-Altman bias were 0.5% (95% CI: −13.6%, 14.7%), 1.1% (95% CI: −20.4%, 22.6%) (Model 1), 0.5% (95% CI: −13.7%, 14.7%) 1.0% (95% CI: −20.1%, 22.2%) (Model 2C), 0.4% (95% CI: −12.2%, 13.0%) and 1.0% (95% CI: −18.2, 20.3) (Model 3), respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>WBM can be reliably estimated using PMA measured in a single chest-CT slice and basic body measurements (age, height, weight, and waist circumference). This method offers a practical and efficient surrogate for muscle assessment based on routinely acquired chest CT images.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heart rate increase results in case of positional venous entrapment","authors":"Quentin Petit,&nbsp;Simon Lecoq,&nbsp;Florian Congnard,&nbsp;Nathan Cronier,&nbsp;Pierre-Yves de Müllenheim,&nbsp;Pierre Abraham,&nbsp;Bénédicte Noury-Desvaux","doi":"10.1111/cpf.70041","DOIUrl":"10.1111/cpf.70041","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Introduction</h3>\u0000 \u0000 <p>Tachycardia has previously been reported as a possible sign of neurovascular entrapment during upper-limb abduction and assumed to result from compression of the adrenergic nerve. However, this increase in heart rate could also be caused by a vascular factor, such as venous entrapment. The aim of this study was to determine whether heart rate increases specifically in the case of venous entrapment during upper-limb dynamic mobilization tasks.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>One hundred and sixteen patients were asked to perform a provocative manoeuvre consisting of consecutive upper limb mobilizations by raising their arms to the “surrender” position (Su, 90° abduction) and then keeping their arms raised in front of the body (“prayer” position, Pra) prior to returning to the initial position (“End”). During this manoeuvre, simultaneous venous (V-PPG) and arterial (A-PPG) photoplethysmography (PPG) recordings were obtained. Participants were categorized by PPG recording analysis as having bilateral venous compression only (<i>V</i>-group) or having no vascular compression (<i>C</i>-group). All other responses (<i>n</i> = 75) were excluded. Heart rate responses in <i>V</i>-group and <i>C</i>-group were compared across arm positions using a linear mixed model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p><i>V</i>-group (<i>n</i> = 17) showed a significantly higher heart rate during the ‘Su’ phase compared to the ‘Rest’ phase (+6.9 bpm, <i>p</i> &lt; 0.001) and compared to the 24 patients of the <i>C</i>-group (+4.9 bpm, <i>p</i> = 0.02).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study suggests that the cardiovascular response to dynamic provocative manoeuvres is found specifically in the presence of positional venous upper-limb entrapment and likely results from decreased cardiac pre-charge rather than from adrenergic nerve excitation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12757505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145888214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analyses of predictive equations for peak oxygen uptake in Japanese cardiac rehabilitation patients","authors":"Asami Ogura,&nbsp;Kazuhiro P. Izawa,&nbsp;Hideto Tawa,&nbsp;Masaaki Wada,&nbsp;Masashi Kanai,&nbsp;Ikko Kubo,&nbsp;Ryohei Yoshikawa","doi":"10.1111/cpf.70040","DOIUrl":"10.1111/cpf.70040","url":null,"abstract":"<p>A nonexercise prediction equation for cardiovascular disease (CVD) patients was developed using the Fitness Registry and the Importance of Exercise National Database (FRIEND), which reported improved accuracy in predicting peak oxygen uptake (VO₂) in CVD patients. However, racial/ethnic differences have been observed in the predicted peak VO₂. The purpose of this study was to evaluate the usefulness of the FRIEND CVD cohort equation in predicting peak VO₂ in Japanese cardiac rehabilitation patients. We retrospectively enroled 362 Japanese cardiac rehabilitation patients (phase II–III) who underwent cardiopulmonary exercise testing. We compared the measured peak VO₂ with the predicted peak VO₂ calculated from three prediction equations: the FRIEND CVD cohort equation, the FRIEND healthy cohort equation, and the Japanese healthy population equation. The measured peak VO₂ was 20.9 ± 5.2 mL/kg/min. Bland-Altman analysis revealed that the FRIEND CVD cohort equation had the lowest bias (−2.32 mL/kg/min), while the FRIEND healthy cohort (11.11 mL/kg/min) and the Japanese healthy population equations (3.14 mL/kg/min) showed higher biases. The FRIEND CVD cohort equation had the highest correlation coefficient (<i>r</i> = 0.61), coefficient of determination (<i>R</i>² = 0.34), and intraclass correlation coefficient (ICC = 0.47) with measured peak VO₂ compared to other equations. In Japanese cardiac rehabilitation patients, the FRIEND CVD cohort equation provided more accurate predictions of peak VO₂ compared to the equation developed for the Japanese healthy population. However, prediction accuracy remained moderate or lower, indicating limitations for clinical use and the need for CVD-specific equations across different racial and ethnic groups.</p>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145780272","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palpation versus hand‑held Doppler for identifying lower‑limb peripheral arteries: Time‑efficiency and reliability in healthy adults","authors":"Rio Nakamine,&nbsp;Ryoga Matsumoto,&nbsp;Misaki Matsumoto,&nbsp;Yoshiyuki Yoshikawa,&nbsp;Noriaki Maeshige","doi":"10.1111/cpf.70039","DOIUrl":"https://doi.org/10.1111/cpf.70039","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Bedside lower‑limb vascular assessment commonly relies on pedal pulse palpation or hand‑held Doppler, yet their relative time‑efficiency and the reliability of Doppler measurements in novices are unclear.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Twenty healthy adults were examined by three undergraduate raters without prior Doppler experience. For dorsalis pedis, anterior tibial, and posterior tibial arteries, each rater performed three trials with palpation and with a hand‑held continuous‑wave Doppler. Primary outcomes were time‑to‑identification and identification success; for Doppler, peak systolic velocity (PSV) reliability was evaluated (intra‑ and inter‑rater intraclass correlation coefficients [ICC] and Bland–Altman).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Differences were defined as Doppler—palpation (positive values indicate longer time for Doppler). Palpation was faster than Doppler for dorsalis pedis (Hodges–Lehmann +6.47 s, 95% confidence interval [CI]: 2.40–8.00; <i>p</i> = 0.004) and posterior tibial arteries (+6.38 s, 1.10–13.61; <i>p</i> = 0.012). The anterior tibial artery was never identified by palpation but was identified by Doppler in all participants (exact McNemar <i>p</i> = 1.91 × 10⁻⁶). Doppler reliability for dorsalis pedis PSV was excellent within raters (ICC [3.1]: 0.926–0.971) and between raters (ICC [2.1]: 0.966), with small mean biases and narrow limits of agreement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>In healthy adults, palpation enables faster identification of dorsalis pedis and posterior tibial pulses, whereas the deeper anterior tibial artery is consistently detected only with Doppler. Doppler‑derived PSV shows excellent reproducibility even among novice examiners. These findings provide methods-level evidence to inform protocol design and training; validation in patient populations is required before any workflow recommendations.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"46 1","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145659466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of sympathicotonia in post-covid condition (long covid) and healthy controls using long-term electrodermal activity (EDA) follow-up","authors":"Timo Mustonen,&nbsp;Pasi Kytölä,&nbsp;Hanna Lantto,&nbsp;Erika Lager,&nbsp;Velina Vangelova-Korpinen,&nbsp;Hélène Virrantaus,&nbsp;Aleksandra Sulg,&nbsp;Sanna Stålnacke,&nbsp;Tatiana Posharina,&nbsp;Ritva Luukkonen,&nbsp;Arja Uusitalo,&nbsp;Päivi Piirilä,&nbsp;Mari Kanerva","doi":"10.1111/cpf.70037","DOIUrl":"10.1111/cpf.70037","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>After SARS-CoV-2 infection, some patients develop post-COVID condition (PCC), often associated with sympathicotonia. This study aimed to characterize sympathicotonia in PCC patients using a novel long-term electrodermal activity (EDA) analysis via a smart ring and evaluate its clinical applicability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Seventeen PCC patients were recruited from a Long Covid outpatient clinic, and 18 healthy controls volunteered. PCC patients were divided based on self-reported symptoms into those with or without sympathicotonia. A 14-day EDA monitoring was conducted. Sympathetic nervous system (SNS) activity was expressed as a double normalized index of electrodermal activity (DNE), with higher levels indicating higher SNS activity. Orthostatic tests were performed to identify orthostatic sympathicotonia. DNE levels, representing EDA, were compared to self-reported and orthostatic sympathicotonia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>DNE levels did not differ between PCC patients with (<i>N</i> = 12) or without (<i>N</i> = 5) self-reported sympathicotonia or compared with nonsympathetic controls. When dividing all participants by orthostatic test results, DNE levels were lower during day (08:00–14:00; <i>p</i> &lt; 0.05) but higher during late night (00:00–02:00; <i>p</i> &lt; 0.05) in those with orthostatic sympathicotonia (<i>N</i> = 21) compared to those without (<i>N</i> = 14), with the 24-h comparison significant (<i>p</i> = 0.022). Among PCC patients, DNE levels were higher in orthostatic nonsympathicotonic (<i>N</i> = 7) than orthostatic sympathicotonic (<i>N</i> = 10) during morning (09:00–12:00; <i>p</i> &lt; 0.05), with the 24-h comparison significant (<i>p</i> = 0.044).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Self-reported symptoms did not distinguish sympathicotonia. However, individuals with orthostatic test-identified sympathicotonia had heightened EDA, indicating increased sympathetic activity, particularly during late night. PCC was not identifiable by EDA. Long-term EDA monitoring may provide an objective tool for detecting sympathicotonia independently of self-reported symptoms.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12641159/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145586139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exercise intensity affects circulating C1q/TNF-related proteins and follistatin-like 1 concentrations","authors":"Michihiro Kon,&nbsp;Koichi Watanabe","doi":"10.1111/cpf.70036","DOIUrl":"10.1111/cpf.70036","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Individuals who engage in high-intensity endurance exercise reportedly have a lower rate of mortality from metabolic diseases than do those who engage in moderate-intensity endurance exercise. However, the mechanisms underlying this association remain unclear. The cytokines C1q/tumour necrosis factor-related protein (CTRP) 3, CTRP9, and follistatin-like 1 (FSTL1) improve metabolic diseases. The secretion of these circulating cytokines is enhanced through acute endurance exercise; however, the effects of exercise intensity on this secretion have not been elucidated. We investigated the effect of exercise intensity on the circulating CTRP3, CTRP9, and FSTL1 concentrations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Ten healthy men performed three experimental trials—moderate-intensity cycling (MIE; 50% maximal oxygen uptake), high-intensity cycling (HIE; 75% maximal oxygen uptake), and control (Con; rest)—in a crossover design. The duration of the exercise trials was varied to match the total energy expenditure between the trials. Blood samples were collected before exercise and at 0 (immediately after exercise) and 120 min after exercise. Circulating CTRP3, CTRP9, and FSTL1 concentrations were measured.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In the HIE trial, significant increases in the circulating concentrations of CTRP3, CTRP9, and FSTL1 were observed after exercise compared to before exercise; however, no significant increases in these cytokines were observed in the MIE trial. Moreover, the increased ratios of the CTRP3, CTRP9, and FSTL concentrations after exercise compared to those before exercise were higher only in the HIE trial compared to the Con trial.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings indicate that circulating CTRP3, CTRP9, and FSTL1 concentrations are affected by exercise intensity during endurance exercise, increasing only after high-intensity exercise.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145512108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Echocardiographic assessment of peak atrial longitudinal strain in paroxysmal atrial fibrillation patients compared to age-matched controls","authors":"Larissa Bastos,&nbsp;Faris Al-Khalili,&nbsp;Magnus Bäck,&nbsp;Aristomenis Manouras,&nbsp;Johan Engdahl,&nbsp;Kambiz Shahgaldi","doi":"10.1111/cpf.70035","DOIUrl":"10.1111/cpf.70035","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To investigate left atrial (LA) function assessed by peak atrial longitudinal strain (PALS) in an elderly population with silent paroxysmal atrial fibrillation (PAF) compared to age-matched control group.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>From the STROKESTOP2-study, patients with newly diagnosed silent PAF were enrolled together in a randomly selected age-matched control group. All patients had NT-proBNP levels between 125 and 900 ng/L. Echocardiographic examinations were performed and analyzed offline using dedicated software. In addition to conventional echocardiographic variables, PALS was measured using a two-dimensional speckle tracking (2D-ST) biplane.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The study population (mean age 76 ± 0.3) demonstrated significantly reduced PALS in patients with PAF (<i>N</i> = 69) compared to controls (<i>N</i> = 94) (23.9% ± 6.5% vs 30.7% ± 7.6%, <i>p</i> &lt; 0.001). In the PAF group, 29 (42%) patients had normal LA volume index (LAVI) defined as <span></span><math>\u0000 <semantics>\u0000 <mrow>\u0000 \u0000 <mrow>\u0000 <mo>≤</mo>\u0000 </mrow>\u0000 </mrow>\u0000 <annotation> $le $</annotation>\u0000 </semantics></math>34 mL/m². When subgroups with normal LAVI were compared, PALS was reduced in PAF compared to controls (25.1 ± 8.0 vs 31.1 ± 7.8, <i>p</i> = 0.001). NT-proBNP levels did not differ between the PAF group (median 228 ng/L) and the control group (median: 217 ng/L) (<i>p</i> = 0.16). In multiple linear regression analysis, left ventricular global longitudinal strain, stroke volume index and LAVI were independent predictors of PALS. Receiver operating characteristic curve identified PALS threshold &lt;22% for predicting risk of silent PAF.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>PALS was significantly reduced in PAF patients even in the absence of significant LA remodeling. PALS &lt;22% predicts risk for silent PAF in general elderly population. In high-risk patients PALS could be used for AF screening enrichment.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12587354/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145444084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of epicardial adiposity on STEMI outcomes: Insights from a prospective cohort","authors":"Ahmet Murat,&nbsp;Gürkan Karaca,&nbsp;Nijad Bakhshaliyev,&nbsp;Ahmet Ekmekci,&nbsp;Ali Kimiaei,&nbsp;Seyedehtina Safaei,&nbsp;Mehmet Eren","doi":"10.1111/cpf.70034","DOIUrl":"10.1111/cpf.70034","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>Cardiovascular diseases, primarily driven by atherosclerosis, remain the leading cause of death worldwide. Key risk factors include diabetes, hyperlipidemia, hypertension, smoking, genetic predispositions and notably, obesity-related visceral adipose tissue (VAT). Like VAT, epicardial adipose tissue (EAT) influences heart function by releasing inflammatory cytokines. This study evaluated the relationship between EAT thickness and coronary artery disease severity, its interaction with risk factors, and its prognostic value for major cardiac and cerebrovascular events in ST-segment elevation myocardial infarction (STEMI) patients after percutaneous intervention (PCI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>We analyzed 138 STEMI patients (124 males and 14 females) treated with primary PCI at our centre, documenting medical and demographic data, cardiovascular history, risk factors, time metrics, physical and clinical examinations, EAT thickness, and biochemical parameters. Follow-ups at 1 and 6 months post-discharge tracked major cardiovascular events.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average age of the patients was 55.14 ± 12.83 years, predominantly male (89.9%), with varying prevalences of diabetes (22.5%), hypertension (38.4%), hyperlipidemia (37%), metabolic syndrome (32.6%), and family history of cardiovascular disease (47.1%). EAT thickness ranged from 1.5 to 11 mm, averaging 3.91 ± 1.42. Patients were divided into tertiles by EAT thickness, showing significant differences in age, weight, body mass index (BMI), thrombolysis in myocardial infarction (TIMI) scores, and number of affected vessels but not in mortality (7.2%), Major adverse cardiac and cerebrovascular events (MACCE) (13.8%), or combined endpoint outcomes across tertiles.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>No correlation was found between EAT thickness and mortality or MACCE in STEMI patients, highlighting the need for validation in long-term studies.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10504,"journal":{"name":"Clinical Physiology and Functional Imaging","volume":"45 6","pages":""},"PeriodicalIF":1.3,"publicationDate":"2025-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}