Renal clearance estimated by rubidium-82 positron emission tomography/computed tomography and technetium-99m-mercaptoacetyltriglycine clearance infusion technique

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2025-02-23 DOI:10.1111/cpf.70000

Stine Sundgaard Langaa, Camilla Lundgreen Duus, Marie Houmaa Vrist, Frank Holden Mose, Claire Anne Fynbo, Jørn Theil, June Anita Ejlersen, Jesper Nørgaard Bech

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引用次数: 0

Abstract

Background

Although numerous techniques exist for renal blood flow (RBF) estimation, none of the methods have been implemented in routine clinical practice due to their inadequacies and burdensomeness. Previously, we evaluated rubidium-82 (⁸²Rb) positron emission tomography/computed tomography (PET/CT) for renal perfusion determination and found strong indications of method precision and reliability. The aim of this study was to compare renal ⁸²Rb clearance with renal technetium-99m-mercaptoacetyltriglycine ([^99mTc]Tc-MAG3) clearance as a first attempt to validate ⁸²Rb PET/CT for renal perfusion estimation using a reference method.

Methods

Ten subjects with essential hypertension underwent two treatment periods, receiving spironolactone and placebo in random order. At the end of each period, each subject completed a ⁸²Rb PET/CT scan and a [^99mTc]Tc-MAG3 clearance study.

Results

⁸²Rb clearance correlated positively with [^99mTc]Tc-MAG3 clearance in both treatment periods. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratio was 0.83 and 0.86 in the placebo and spironolactone treatment periods, respectively.

Conclusion

The correlation between ⁸²Rb clearance and [^99mTc]Tc-MAG3 clearance may indicate that PET/CT determined ⁸²Rb clearance can act as an estimator of renal perfusion. The [^99mTc]Tc-MAG3-to-⁸²Rb clearance ratios suggest that the extraction fraction of ⁸²Rb is higher than that of [^99mTc]Tc-MAG3, further suggesting ⁸²Rb clearance as an estimator of flow. However, further studies are warranted to validate use of ⁸²Rb PET/CT for flow estimation.

Abstract Image

查看原文本刊更多论文

通过铷-82正电子发射断层扫描/计算机断层扫描和锝-99m-巯基乙酰甘油三酯清除输注技术估计肾脏清除率

背景肾血流量（RBF）的估算方法有很多，但由于其不足和繁琐，没有一种方法在常规临床实践中得到应用。先前，我们评估了铷-82 （82Rb）正电子发射断层扫描/计算机断层扫描（PET/CT）用于肾脏灌注测定，并发现该方法具有很强的精确度和可靠性。本研究的目的是比较肾脏82Rb清除率与肾脏锝-99m-巯基乙酰三甘氨酸（[99mTc]Tc-MAG3）清除率，作为验证82Rb PET/CT使用参考方法评估肾脏灌注的第一次尝试。方法10例原发性高血压患者分2期治疗，随机给予螺内酯和安慰剂。在每个时间段结束时，每位受试者完成82Rb PET/CT扫描和[99mTc]Tc-MAG3清除研究。结果两个治疗期82Rb清除率与[99mTc]Tc-MAG3清除率呈正相关。安慰剂组和螺内酯组[99mTc] tc - mag3对82rb的清除率分别为0.83和0.86。结论82Rb清除率与[99mTc]Tc-MAG3清除率的相关性提示PET/CT测定的82Rb清除率可作为肾灌注的一个指标。[99mTc]Tc-MAG3与82Rb的间隙比表明，82Rb的萃取分数高于[99mTc]Tc-MAG3，进一步表明82Rb间隙是流量的一个估计指标。然而，需要进一步的研究来验证使用82Rb PET/CT进行流量估计。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.