Pulmonary blood volume as a marker of adenosine-induced cardiac hyperemia: A Rubidium-82 study

IF 1.3 4区医学 Q4 PHYSIOLOGY

Clinical Physiology and Functional Imaging Pub Date : 2025-02-26 DOI:10.1111/cpf.70001

Martin Lyngby Lassen, Jacob Peter Hartmann, Christina Byrne, Ronan M. G. Berg, Andreas Kjær, Philip Hasbak

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Abstract

Purpose

To investigate the efficacy of pulmonary blood volume (PBV) as a marker of the cardiac hyperemic response to adenosine during myocardial perfusion imaging (MPI).

Methods

Forty healthy subjects underwent four consecutive Rubidium-82 rest/adenosine-stress MPI: two sessions were conducted without any caffeine consumption (baseline), while the remaining two sessions involved controlled caffeine consumption (arm 1: 100 and 300 mg; arm 2: 200 and 400 mg). We evaluate the ability of the stress-to-rest ratio of PBV (PBV ratio) to identify an adequate cardiac hyperemic response. The adequate hyperemic response was defined as a stress myocardial blood flow >2 mL/g/min and a corresponding myocardial flow reserve >68% of the maximum myocardial flow reserve obtained during the baseline scans.

Results

Based on 126 MPI sessions conducted in 40 subjects, the PBV ratio demonstrated a sensitivity of 78% and a specificity of 74% in detecting adequate cardiac hyperemia. The positive predictive value was 95%, while the negative predictive value was 36%.

Conclusion

The PBV ratio permits the identification of adequate hyperemic response with sensitivities and specificities comparable to existing markers.

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来源期刊

Clinical Physiology and Functional Imaging 医学-生理学

CiteScore

3.40

自引率

5.60%

发文量

审稿时长

6-12 weeks

期刊介绍： Clinical Physiology and Functional Imaging publishes reports on clinical and experimental research pertinent to human physiology in health and disease. The scope of the Journal is very broad, covering all aspects of the regulatory system in the cardiovascular, renal and pulmonary systems with special emphasis on methodological aspects. The focus for the journal is, however, work that has potential clinical relevance. The Journal also features review articles on recent front-line research within these fields of interest. Covered by the major abstracting services including Current Contents and Science Citation Index, Clinical Physiology and Functional Imaging plays an important role in providing effective and productive communication among clinical physiologists world-wide.