Clinical Oral Investigations最新文献

{"title":"Evaluating dental developmental abnormalities in osteogenesis imperfecta: associations with timing and cumulative exposure to intravenous pamidronate- a pilot study.","authors":"Kübra Demir, Aslı Derya Kardelen, Ayça Aslanger, Cansu Koç, Ayşe Pınar Öztürk, Çağrı Güleç, Firdevs Baş, Elif Bahar Tuna İnce, Güven Toksoy","doi":"10.1007/s00784-026-07194-y","DOIUrl":"10.1007/s00784-026-07194-y","url":null,"abstract":"<p><strong>Objectives: </strong>Bisphosphonates are widely used in pediatric Osteogenesis Imperfecta (OI), but their potential impact on odontogenesis is not well characterized. We examined whether intravenous pamidronate exposure is associated with specific developmental dental abnormalities in OI, with particular attention to treatment timing, duration, cumulative exposure, and gender.</p><p><strong>Materials and methods: </strong>Fifty-eight individuals with OI (38 treated and 20 untreated) underwent standardized clinical examination and panoramic radiography. Outcomes included enamel hypoplasia, dentinogenesis imperfecta (DI), dens evaginatus (DE), microdontia, hypodontia, taurodontism, bulbous crowns, pulpal obliteration, short roots, root dilaceration, and tooth fractures. Treated individuals were further stratified by whether treatment began before or after age two years. Associations with treatment duration and cycle count were also evaluated.</p><p><strong>Results: </strong>Enamel hypoplasia occurred only in treated participants (p = 0.005). Initiation of therapy before age two years was associated with a higher prevalence of enamel hypoplasia (p = 0.036). Enamel hypoplasia showed a significant association with treatment in females (p = 0.034). Root dilaceration was the only abnormality associated with cycle count (p = 0.008). Longer treatment duration was associated with DE (p = 0.021), microdontia (p = 0.026), and pulpal obliteration (p = 0.002).</p><p><strong>Conclusions: </strong>In this exploratory pilot cohort, enamel hypoplasia showed the clearest association with pamidronate exposure, particularly when treatment began before age two years. Root dilaceration demonstrated a cumulative-exposure pattern. Other abnormalities appeared more strongly related to underlying disease severity than treatment variables.</p><p><strong>Clinical relevance: </strong>These findings underscore the importance of structured dental surveillance in children receiving pamidronates during early developmental windows.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and associated factors of medication-related osteonecrosis of the jaw in breast cancer patients with bone metastases: a nationwide registry study in Finland.","authors":"Miika Kujanpää, Ville Vuollo, Antti Tiisanoja, Marja-Liisa Laitala, Jussi Koivunen, George K Sándor, Saujanya Karki","doi":"10.1007/s00784-026-07171-5","DOIUrl":"10.1007/s00784-026-07171-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the incidence of MRONJ and associated factors among breast cancer patients with bone metastases in Finland.</p><p><strong>Materials and methods: </strong>This retrospective cohort study included all adult patients with breast cancer and bone metastases who were prescribed antiresorptive therapy between 2013 and 2015. Patients were identified from national health care registers and followed through 2020. The outcome variable was MRONJ (M87.1). Covariates included age, oral diseases, dental procedures, type of antiresorptive (AR) prescribed, comorbidities, and concomitant medications.</p><p><strong>Results: </strong>A total of 652 patients met the inclusion criteria. The incidence of MRONJ ranged from 0% to 2.2% among bisphosphonate users, compared with 12.6% among denosumab users and 15.3% among patients receiving sequential bisphosphonate and denosumab therapy. Both denosumab monotherapy and sequential bisphosphonate-denosumab therapy were associated with substantially increased MRONJ risk compared with bisphosphonate therapy.</p><p><strong>Conclusions: </strong>Denosumab use and infection-related invasive dental procedures showed the strongest associations with MRONJ in this study population.</p><p><strong>Clinical relevance: </strong>MRONJ incidence differed by type of antiresorptive therapy, with higher occurrence among patients using denosumab or bisphoshonates followed by denosumab compared with bisphosphonates. MRONJ was more frequent among patients who underwent infection-related invasive dental procedures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13624040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of efficacy of xenogeneic pericardial membrane enriched with two different forms of platelet concentrates in the treatment of gingival recession- a randomized clinical trial.","authors":"Kiran Choudhary, Anupama Tadepalli, Harinath Parthasarathy, Sashank K, Priyanka K Cholan, Lakshmi Ramachandran","doi":"10.1007/s00784-026-07176-0","DOIUrl":"10.1007/s00784-026-07176-0","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized split-mouth study aimed to compare the clinical outcomes of xenogeneic pericardial membrane (XCM) enriched with injectable platelet-rich fibrin (i-PRF) or advanced platelet-rich fibrin plus membrane (A-PRF+) in the treatment of isolated gingival recession defects.</p><p><strong>Materials and methods: </strong>Twenty-three systemically healthy subjects presenting with 46 Cairo's RT1/RT2 gingival recession defects in maxilla were treated with coronally advanced flap (CAF) and XCM impregnated with i-PRF (group 1) or with CAF, XCM and A-PRF+ membrane combination (group 2). Clinical parameters were recorded at baseline, 3, and 6 months. Wilcoxon signed-rank test was used for data analysis.</p><p><strong>Results: </strong>Both groups showed significant reduction in recession depth from baseline to 3 and 6 months (p < 0.001). At 6 months, group 1 demonstrated 87.6 ± 20.16% mean root coverage (MRC) with 65.21% sites attaining complete root coverage (CRC) and group 2 showed a MRC of 96.74 ± 11.44% with 91.3% sites having CRC (p < 0.05). Intergroup comparison at 6 months revealed that group 2 sites had a significantly lower recession depth (0.09 ± 0.29 vs. 0.41 ± 0.66), greater gingival thickness (1.20 ± 0.2 vs. 0.98 ± 0.15), increased width of attached gingiva (2.0 ± 0.52 vs.1.5 ± 0.79), and higher mean root coverage esthetic scores (9.30 ± 0.8 vs. 8.34 ± 1.02) than group 1 (p < 0.05).</p><p><strong>Conclusions: </strong>This preliminary short-term research suggests that the adjunctive use of A-PRF + to XCM resulted in more favorable root coverage outcomes than i-PRF-enriched XCM in the management of maxillary RT1 and RT2 recession defects.</p><p><strong>Clinical relevance: </strong>CAF, along with the XCM and A-PRF+ membrane combination, may be considered as a viable treatment option for enhancing root coverage outcomes and improving the gingival phenotype.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149080029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The spatial mandibular triangle framework for quantifying structural and positional features of mandibular asymmetry: a retrospective diagnostic accuracy study.","authors":"Lingbo Lu, Wen Tang, Jinyi Zhu, Xinyao Qian, Hu Li, Yingji Zhou, Lizhe Xie, Bin Yan","doi":"10.1007/s00784-026-07188-w","DOIUrl":"10.1007/s00784-026-07188-w","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and internally validate the Spatial Mandibular Triangle (SMT), a novel geometric framework that quantifies morphological and positional features of mandibular asymmetry.</p><p><strong>Materials and methods: </strong>This retrospective diagnostic accuracy study initially included 416 eligible participants. After expert assessment, 17 cases with discordant expert classifications were excluded, leaving 399 participants for analysis: 273 with mandibular asymmetry and 126 controls. A simplified SMT was constructed using bilateral condylar centers and menton. Two dimensionless indices were derived: the Structural Mandibular Asymmetry Index (SMAI), reflecting morphological asymmetry, and the Positional Mandibular Asymmetry Index (PMAI), reflecting spatial displacement. The discriminative performance of each index was evaluated against its corresponding expert-concordant classifications using receiver operating characteristic analysis, stratified 5-fold cross-validation, and bootstrap resampling.</p><p><strong>Results: </strong>Participants with mandibular asymmetry exhibited higher SMAI and PMAI values than controls. Within the mandibular asymmetry cohort, SMAI discriminated severe from mild-to-moderate structural asymmetry with an area under the curve (AUC) of 0.932, yielding an exploratory cutoff of 2.9% at the 95% specificity criterion. PMAI identified clinically significant positional asymmetry with an AUC of 0.961, yielding an exploratory cutoff of 3.9% at the 95% sensitivity criterion. Bootstrap resampling supported the stability of the threshold estimates, and cross-validation showed consistent cutoff ranges.</p><p><strong>Conclusions: </strong>The SMT framework provides complementary three-dimensional quantification of structural and positional features of mandibular asymmetry. SMAI and PMAI showed promising discriminative performance in internal validation.</p><p><strong>Clinical relevance: </strong>SMT-based phenotyping may provide complementary quantitative information for characterizing the structural and positional features of mandibular asymmetry and may support comprehensive clinical assessment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How laser etching affects the clinical performance of a \"no-wait\" universal adhesive: 36-month results.","authors":"Gulnaz Aydemir, Jale Gorucu, A Ruya Yazici","doi":"10.1007/s00784-026-07166-2","DOIUrl":"10.1007/s00784-026-07166-2","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the 36-month clinical performance of a no-wait universal adhesive in non-carious cervical lesions (NCCLs) according to etching method and application mode.</p><p><strong>Materials and methods: </strong>Forty-one participants with at least five NCCLs received 215 restorations, which were randomly assigned to five groups according to five surface-conditioning and adhesive application protocols: Enamel and dentin etching with phosphoric acid (ED-A), selective enamel etching with phosphoric acid (SEE-A), self-etch (SE; control group), enamel and dentin etching with laser (ED-L), selective enamel etching with laser (SEE-L). Restorations were placed by a single operator using Clearfil Universal Bond Quick and Clearfil Majesty ES-2 and were evaluated at baseline, 6, 12, 18, 24, and 36 months using modified USPHS criteria. Survival was analyzed using Kaplan-Meier survival analysis with the log-rank test, and categorical outcomes were analyzed using Generalized Estimating Equations (GEE) (p < 0.05).</p><p><strong>Results: </strong>The 36-month recall rate was 97.5% (40 participants; 199 restorations). At 36 months, retention loss was greater in the ED-A group than in the SEE-A and SE groups and in the SEE-L group than in the SEE-A and SE groups (p = 0.036 for all comparisons). Marginal discoloration was greater in the SE group than in the ED-A and SEE-A groups (p = 0.022 and p = 0.004, respectively) and in the SEE-L group than in the SEE-A group (p = 0.014). Marginal adaptation was poorer in the SE group than in the ED-A, SEE-A, and ED-L groups (p = 0.001, p = 0.011, and p = 0.013, respectively). Marginal discoloration increased and marginal adaptation deteriorated significantly over time in all groups (p < 0.05).</p><p><strong>Conclusions: </strong>Phosphoric acid enamel etching provided the most favorable long-term marginal performance, whereas the SE and selective laser etching protocols showed less favorable marginal behavior.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-dependent prognostic value of perioperative changes in the systemic inflammation response index for overall survival in oral tongue squamous cell carcinoma: a retrospective cohort study.","authors":"Silong Zhong, Bin Shi, Rongrong Fu, Qiuping Zhuo, Guohui Li, Yifan Xu, Jinteng Chen, Yu Qiu, Bingju Gao, Lisong Lin, Jing Wang, Baochang He","doi":"10.1007/s00784-026-07151-9","DOIUrl":"10.1007/s00784-026-07151-9","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the association between perioperative changes in the systemic inflammation response index (SIRI) and overall survival (OS) in patients with oral tongue squamous cell carcinoma (OTSCC), with a focus on its time-dependent prognostic value.</p><p><strong>Materials and methods: </strong>This single-center retrospective cohort study included 264 patients with primary OTSCC who underwent curative-intent resection between June 2015 and February 2025. ΔSIRI was defined as postoperative SIRI minus preoperative SIRI. Time-dependent receiver operating characteristic (ROC) analysis was used to derive the ΔSIRI cutoff. Survival analyses included Kaplan-Meier curves, Cox regression, restricted mean survival time (RMST), and time-varying coefficient Cox models.</p><p><strong>Results: </strong>During follow-up, 70 deaths occurred. In multivariable Cox analysis, high ΔSIRI was significantly associated with poorer OS (adjusted hazard ratio [HR] = 2.13, 95% confidence interval [CI]: 1.24-3.67, P = 0.006). Adjusted RMST analysis showed an 8.02-month reduction in restricted mean survival time in the high ΔSIRI group within 60 months compared with the low ΔSIRI group (95% CI: - 12.76 to - 3.28, P < 0.001). The time-varying coefficient Cox model indicated that the adverse prognostic association of high ΔSIRI was most pronounced during the early follow-up period and gradually attenuated over time.</p><p><strong>Conclusions: </strong>High perioperative ΔSIRI was associated with poorer OS in patients with OTSCC. ΔSIRI may serve as an adjunctive dynamic inflammatory-immune marker for early postoperative risk stratification, although external validation is warranted.</p><p><strong>Clinical relevance: </strong>Perioperative ΔSIRI may provide supplementary information for identifying patients with OTSCC at higher early postoperative mortality risk.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychometric validation and reliability of the Turkish version of the caries impacts and experiences questionnaire for children (CARIES-QC).","authors":"Merve Uslu, Mehmet Bani","doi":"10.1007/s00784-026-07155-5","DOIUrl":"10.1007/s00784-026-07155-5","url":null,"abstract":"<p><strong>Objectives: </strong>The Caries Impacts and Experiences Questionnaire for Children (CARIES-QC) is a disease-specific patient-reported outcome measure (dPROM) developed to capture, from a first-person perspective, the impact of dental caries on the quality of life of children. The present study aimed to translate and culturally adapt the CARIES-QC into Turkish (CARIES-QC/T) and to assess its reliability and validity in a sample of Turkish-speaking children with active dental caries.</p><p><strong>Materials and methods: </strong>Translation and cultural adaptation of the CARIES-QC into Turkish were carried out following internationally recognised guidelines for the cross-cultural adaptation of health-related quality-of-life instruments. The adapted questionnaire (CARIES-QC/T) was administered to 307 children aged 5-15 years with active dental caries. Internal consistency was evaluated using Cronbach's α and the inter-item correlation matrix. Test-retest reliability was assessed in a subgroup of 60 participants who completed the questionnaire again after a four-week interval, using intraclass correlation coefficients (ICC). Construct validity was examined through confirmatory factor analysis (CFA) of the hypothesised single-factor structure, and convergent validity through the Spearman correlation between the total CARIES-QC/T score and the single global item.</p><p><strong>Results: </strong>The sample comprised 307 children (152 girls, 49.5%; 155 boys, 50.5%) aged 5-15 years. The CARIES-QC/T showed high internal consistency (Cronbach's α = 0.919), with inter-item correlations ranging from 0.251 to 0.677. Test-retest reliability was high, with a total-score ICC of 0.918 and item-level ICCs ranging from 0.724 to 0.912. Confirmatory factor analysis supported the hypothesised single-factor structure; model fit indices were at the borderline of conventional thresholds (χ²/df = 4.50, RMSEA = 0.10, GFI = 0.870, CFI = 0.896, TLI = 0.873), with standardised factor loadings of 0.46-0.82. Convergent validity, assessed against the global item, was strong (Spearman's ρ = 0.937, p < 0.001).</p><p><strong>Conclusions: </strong>Taken together, these findings indicate that the CARIES-QC/T demonstrates adequate psychometric properties for assessing caries-specific oral health-related quality of life in Turkish-speaking children. However, the borderline confirmatory factor model fit and the absence of longitudinal evidence indicate that further evaluation is required before the instrument can be recommended as a fully established outcome measure.</p><p><strong>Clinical relevance: </strong>A Turkish version of the CARIES-QC with documented internal consistency and test-retest reliability provides clinicians and researchers with a feasible, child-reported instrument for assessing caries-specific impacts on quality of life in Turkish-speaking children, pending further evidence on responsiveness and measurement invariance across age groups.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between pterygomaxillary separation during surgically assisted rapid maxillary expansion and three-dimensional morphological and morphometric changes of the mandibular condyle: a cone-beam computed tomography study.","authors":"İsmail Burak Halat, Zeynep Gümrükçü, Taha Emre Köse","doi":"10.1007/s00784-026-07162-6","DOIUrl":"10.1007/s00784-026-07162-6","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;This study aimed to evaluate the association between pterygomaxillary separation (PMS) performed during surgically assisted rapid maxillary expansion (SARME) and three-dimensional morphological and morphometric changes of the mandibular condyle using cone-beam computed tomography (CBCT).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;This retrospective CBCT-based study included 50 independent adult patients who underwent SARME, with 25 patients in each PMS group. Both condyles of each patient were segmented and measured separately to preserve side-specific morphological information, yielding 100 condylar imaging observations from 50 patients. Preoperative and postoperative CBCT data were used to perform condylar segmentation and generate three-dimensional models. Condylar volume, surface area, root mean square distance (RMS), mean signed distance (MSD), minimum and maximum surface distances, apposition/resorption distribution, and right-left condylar asymmetry were assessed. To account for the correlation between bilateral condyles from the same patient, the principal condyle-level outcomes were analyzed using generalized estimating equations (GEE) with patient as the clustering unit and robust standard errors. Condylar volume and surface area were evaluated longitudinally using the PMS group × time interaction, and a patient-level sensitivity analysis based on bilateral condylar averages was additionally performed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Baseline condylar volume and surface area values were generally similar between the PMS(+) and PMS(-) groups (p &gt; 0.05). After SARME, measurable morphological and morphometric changes were observed in the condyle in both groups. After accounting for within-patient clustering, the estimated between-group difference in longitudinal condylar volume change was 47.61 mm³ (95% CI, - 1.31 to 96.53; p = 0.056). Nominal cluster-adjusted between-group associations were observed for RMS (estimated difference, 0.067 mm; 95% CI, 0.004 to 0.131; p = 0.038; q = 0.113) and minimum surface distance (estimated difference, - 0.240 mm; 95% CI, - 0.434 to - 0.046; p = 0.015; q = 0.092). However, neither remained statistically significant after Benjamini-Hochberg FDR correction. Moreover, these surface-distance estimates could not be demonstrated to exceed imaging and measurement uncertainty and were therefore regarded as exploratory observations of uncertain methodological and clinical significance. The longitudinal condylar volume interaction was also not statistically significant after correction (p = 0.056; q = 0.113), and no statistically detectable differences were observed for surface area change, MSD, or maximum surface distance. Patient-level sensitivity analysis based on bilateral condylar averages yielded a similar overall pattern. Apposition/resorption distributions were summarized descriptively without formal condyle-level inference.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;After accoun","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral squamous cell carcinoma arising from oral epithelial dysplasia shows high postoperative recurrence despite favorable histopathology.","authors":"Yiming Hu, Xiaoxian Zhao, Miao Wang, Zhiyuan Zhang, Shufang Jin, Hailong Ma","doi":"10.1007/s00784-026-07164-4","DOIUrl":"10.1007/s00784-026-07164-4","url":null,"abstract":"<p><strong>Objectives: </strong>We sought to determine whether oral epithelial dysplasia (OED)-derived oral squamous cell carcinoma (OSCC) represents a clinically and pathologically distinct subtype, given that a substantial subset of OSCC is known to arise from OED.</p><p><strong>Materials and methods: </strong>This retrospective study analyzed 335 patients with OSCC treated at our institution. OED-OSCC was defined as OSCC in patients with a documented history of biopsy-proven oral epithelial dysplasia, irrespective of the specific clinical lesion.</p><p><strong>Results: </strong>OED-derived OSCC (OED-OSCC), defined by pathologically confirmed dysplasia rather than clinical presentation, comprised 195 (58.2%) patients in the cohort. Compared with non-OED-OSCC, it demonstrated less aggressive tumor-centric features including shallower DOI, lower PNI, earlier T stage, and fewer nodal metastases, yet paradoxically greater cumulative surgical burden with more patients undergoing multiple resections. Recurrence in OED-OSCC was significantly associated with margin dysplasia, which was more frequent than in non-OED-OSCC (74.00% vs. 48.97%). Moreover, recurrence rates increased with margin dysplasia severity (mild: 60%; moderate: 73.08%; severe: 100%), underscoring that field cancerization at the primary site may contribute to the distinct clinical behavior of OED-OSCC. The clinical value of dysplasia-free margins warrants prospective evaluation, as even mild dysplasia was associated with a 60% recurrence rate.</p><p><strong>Conclusions: </strong>OED-OSCC represents a pathologically anchored subgroup in which margin dysplasia severity was associated with high recurrence despite favorable tumor-centric features. These findings support prospective evaluation of mucosal margin status in risk stratification.</p><p><strong>Clinical relevance: </strong>By anchoring OSCC classification to histopathologically confirmed dysplasia, OED-OSCC identifies patients with a dysplastic background and elevated observed recurrence risk who may merit enhanced surveillance.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Saturated anacardic acid preserves root dentin collagen under cariogenic challenge.","authors":"Bruna Leis Endres, Isabela Monici Silva, Luiz Antonio Soares Romeiro, Caio Matheus Ferreira, Antônio Djalma Santos, Sebastião William da Silva, Márcio Botelho de Castro, Leandro Augusto Hilgert, Luana Wouk, Andressa Souza de Oliveira, Fernanda Cristina Pimentel Garcia, Naile Dame-Teixeira","doi":"10.1007/s00784-026-07178-y","DOIUrl":"10.1007/s00784-026-07178-y","url":null,"abstract":"<p><strong>Objective: </strong>We aimed to evaluate changes in the structure and organization of root dentin collagen in bovine incisors pre-treated with an anacardic acid derivative (LDT11) following an in vitro cariogenic challenge, thereby contributing to understanding of dentin matrix biology and biomodification strategies for root caries management.</p><p><strong>Materials and methods: </strong>Bovine root dentin specimens were demineralized and pre-treated with LDT11 (100 µg/mL) or distilled water (control). Samples were then subjected to a cariogenic challenge for 7 days. Histological sections were stained with Picrosirius and analyzed by polarized light microscopy to assess collagen organization and residual collagen area. Additional analyses were performed using Fourier Transform Infrared Spectroscopy in Attenuated Total Reflectance mode (FTIR-ATR) and thermogravimetric analysis (TGA).</p><p><strong>Results: </strong>LDT11-pretreated samples showed a significantly greater residual collagen area compared to controls (p < 0.01), with preservation of a dense and organized fibrillar network. FTIR-ATR analysis revealed spectral changes consistent with hydrogen bonding and collagen biomodification. Principal component analysis demonstrated clear separation between treated and untreated groups. In contrast, TGA showed no significant differences in total collagen mass loss, suggesting a localized effect of LDT11 at the superficial dentin layer.</p><p><strong>Conclusion: </strong>LDT11 promotes preservation of the dentin collagen matrix under cariogenic challenge and exhibits potential as a collagen biomodifier through chemical interaction with the organic matrix. Its effects appear to be primarily surface-oriented, contributing to structural stability without altering collagen mass.</p><p><strong>Clinical relevance: </strong>Potential of LDT11 as a dentin-interacting agent that can help control collagenolytic degradation as an adjunct for managing root caries lesions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619660/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}