Clinical Oral Investigations最新文献

{"title":"Automatic jawbone structure segmentation on dental CBCT images via deep learning.","authors":"Yuan Tian, Jin Hao, Mingzheng Wang, Zhejia Zhang, Ge Wang, Dazhi Kou, Lichao Liu, Xiaolin Liu, Jie Tian","doi":"10.1007/s00784-024-06061-y","DOIUrl":"10.1007/s00784-024-06061-y","url":null,"abstract":"<p><strong>Objectives: </strong>This study developed and evaluated a two-stage deep learning-based system for automatic segmentation of mandibular cortical bone, mandibular cancellous bone, maxillary cortical bone and maxillary cancellous bone on cone beam computed tomography (CBCT) images.</p><p><strong>Materials and methods: </strong>A dataset containing 155 CBCT scans acquired with different parameters was obtained. A two-stage deep learning-based system was developed for automatically segmenting jawbone structures. The Dice similarity coefficient (DSC) and average symmetric surface distance (ASSD) were used to assess the segmentation performance of the system by comparing the automatic segmentation results with the ground truth. The impact of dental and quality abnormalities on segmentation performance was analysed, and a comparison of automatic segmentation (AS) with manually refined segmentation (MRS) was reported.</p><p><strong>Results: </strong>The system achieved promising segmentation performance, with average DSC values of 93.69%, 96.83%, 86.14% and 95.57% and average ASSD values of 0.13 mm, 0.16 mm, 0.29 mm and 0.41 mm for the mandibular cortical bone, mandibular cancellous bone, maxillary cortical bone and maxillary cancellous bone, respectively. Quality abnormalities had a negative impact on segmentation performance. The performance metrics (DSCs > 98.8% and ASSDs < 0.1 mm) indicated high overlap between the AS and MRS.</p><p><strong>Conclusion: </strong>The proposed system offers an accurate and time-efficient method for segmenting jawbone structures on CBCT images.</p><p><strong>Clinical relevance: </strong>Automatically segmenting jawbone structures is essential in most digital dental workflows. The proposed system has considerable potential for application in digital clinical workflows to assist dentists in making more accurate diagnoses and developing patient-specific treatment plans.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"663"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A laboratory study to assess the physico-chemical properties of BioRoot RCS and BioRoot Flow exposed to citric acid and EDTA irrigating solutions.","authors":"Goda Bilvinaitė, Saulius Drukteinis, Simas Šakirzanovas, Paul Mh Dummer","doi":"10.1007/s00784-024-06067-6","DOIUrl":"10.1007/s00784-024-06067-6","url":null,"abstract":"<p><strong>Objective: </strong>To assess physico-chemical properties of BioRoot RCS (powder-to-liquid formulation) and BioRoot Flow (pre-mixed formulation) after exposure to citric acid (CA) and EDTA.</p><p><strong>Methods: </strong>BioRoot RCS and BioRoot Flow specimens (5 × 2 mm) were incubated for 28 days at 37 °C before being treated with test solution (distilled water, 17% EDTA, 10% CA, 20% CA or 40% CA). Changes in mass, ion release (inductively coupled plasma optical emission spectroscopy), phase composition (X-ray diffraction and Raman spectroscopy), surface morphology (scanning electron microscopy and energy dispersive spectroscopy) were evaluated. The Shapiro-Wilk, Levene and one-way ANOVA, followed by Tukey's test, were used for statistical analysis (p < 0.05).</p><p><strong>Results: </strong>The greatest mass loss, ion release and surface morphological changes (pores and cracks) of BioRoot RCS and BioRoot Flow occurred in 10% and 20% CA. No significant differences were identified between BioRoot RCS and BioRoot Flow in distilled water and EDTA (p > 0.05), whereas BioRoot Flow was significantly more soluble than BioRoot RCS in all CA solutions (p < 0.001). The main phase identified for both materials was zirconium oxide, which remained unaffected by the solutions.</p><p><strong>Conclusions: </strong>Within the limitations of the study, 10% and 20% CA were more effective than distilled water, 17% EDTA and 40% CA in terms of dissolving BioRoot RCS and BioRoot Flow. The BioRoot Flow was significantly more soluble in all CA solutions than BioRoot RCS.</p><p><strong>Clinical significance: </strong>10% and 20% CA solutions may have a potential to be used as a solvent for hydraulic calcium silicate sealers during endodontic retreatment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"662"},"PeriodicalIF":3.1,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an experimental desensitizer with a hydroxyapatite-capsaicin composite applied before in-office dental bleaching on hydrogen peroxide diffusion, color and surface changes.","authors":"Byron Carpio-Salvatierra, Karine Leticia da Silva, Michael William Favoreto, Claudia González, Maria Cristina Rockenbach Binz Ordóñez, Alessandro D Loguercio, Paulo Vitor Farago","doi":"10.1007/s00784-024-06041-2","DOIUrl":"10.1007/s00784-024-06041-2","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate a prior application of an experimental desensitizer containing a hydroxyapatite-capsaicin composite (HAp-CAP) in different concentrations on hydrogen peroxide (HP) diffusion into the pulp chamber, bleaching efficacy (BE) and on physical and chemical alterations of the enamel surface after in-office bleaching.</p><p><strong>Materials and methods: </strong>Forty sound premolars were randomized in five groups according to each experimental condition (n = 8): no bleaching (negative control), only bleaching (positive control), 0.1%, 1% and 5% of HAp-CAP. Four groups were submitted to in-office bleaching (HP 35%) post-desensitizer application. The HP concentration (µg/mL) on the pulp chamber was measured by UV-Vis spectrophotometer. The BE was measured by digital spectrophotometer (ΔE_ab, ΔE₀₀ and ΔWI_D) before and after 7 days bleaching. Enamel tooth fragments obtained from twenty molars were submitted to the same experimental conditions and analyzed using FE-SEM and EDS, Vickers microhardness (VHN), Raman spectroscopy, and nanoroughness (Ra) by AFM to evaluate morphologic and chemical changes on enamel surface. All data were submitted to statistical analysis (α = 0.05).</p><p><strong>Results: </strong>The groups treated with HAp-CAP exhibited a lower concentration of HP in the pulp chamber compared to only bleaching group (p < 0.05). There were no significant differences observed in BE between HAp-CAP groups and only bleaching group (p > 0.05). Only HAp-CAP 5% showed no significant differences in VHN values when compared to no bleaching group (p > 0.05). There were no significant differences among any group in Ra values (p > 0.05). The groups submitted to HAp-CAP showed a higher mineral concentration when compared to only bleaching group (p < 0.05).</p><p><strong>Conclusion: </strong>Desensitizers containing HAp-CAP up to 5% effectively reduce HP diffusion into the pulp chamber after in-office bleaching, without interfering to BE and Ra, as well as prevent enamel demineralization.</p><p><strong>Clinical relevance: </strong>The use of desensitizers containing HAp-CAP during in-office bleaching treatments offers a promising approach to reduce the risk of pulp irritation caused by hydrogen peroxide diffusion, without compromising the bleaching effectiveness or causing surface roughness.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"659"},"PeriodicalIF":3.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Possible immunomodulatory role of Filifactor alocis through beta-defensin 2 in gingival keratinocytes.","authors":"Lorena S Gutierrez, Daniela L Zandim-Barcelos, Sigrun Eick, Maria Eduarda S Lopes, Joni A Cirelli, Andressa V B Nogueira, James Deschner","doi":"10.1007/s00784-024-06043-0","DOIUrl":"10.1007/s00784-024-06043-0","url":null,"abstract":"<p><strong>Objectives: </strong>The present study aimed to investigate a possible immunomodulatory role of the periodontopathogen Filifactor alocis through the antimicrobial peptide hBD-2 on the expression of chemokines in human gingival keratinocytes.</p><p><strong>Materials and methods: </strong>Cells were cultured in the presence or absence of periodontopathogenic bacteria, such as F. alocis, Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, and Treponema denticola, to evaluate the regulation of hBD-2, CXCL8 and CCL20. Furthermore, the cells were exposed or not to hBD-2 and the expression of CXCL8 and CCL20 and their receptors was evaluated.</p><p><strong>Results: </strong>All bacteria induced a significant upregulation of hBD-2, CXCL8, and CCL20 gene expressions. In addition, F. alocis significantly increased their protein levels, as detected by ELISA. Pre-incubation of the cells with the TLR2 inhibitor resulted in a significant downregulation of hBD-2 expression in F. alocis-treated cells. Gingival keratinocytes exposed to hBD-2 resulted in a significant and dose-dependent increase of all chemokines and their receptors.</p><p><strong>Conclusions: </strong>F. alocis increased the production of chemotactic cytokines, suggesting an increase in the recruitment of immunoinflammatory cells in periodontal diseases. The chemotaxis-promoting effect is partly direct, but is also mediated via hBD-2. F. alocis stimulates the synthesis of hBD-2, which in turn could promote the expression and synthesis of these chemokines and their receptors. In addition, hBD-2 has an autostimulatory effect and stimulates the synthesis of these chemokines, so that the chemotaxis triggered by F. alocis is further fueled.</p><p><strong>Clinical relevance: </strong>F. alocis and hBD-2 have a significant role in periodontitis, showing their importance for diagnostic and treatment approaches.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"658"},"PeriodicalIF":3.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Radiographic characteristics and chronological patterns of transient apical breakdown (TAB) in luxated permanent teeth: A retrospective observational study.","authors":"Isabela Fernandes Dos Santos, Luíza Rothier Coutinho da Silveira, Rayner Afonso Santos, Tania Mara Pimenta Amaral, Daniela Augusta Barbato Ferreira, Maria Ilma de Souza Gruppioni Côrtes, Enrico Antônio Colosimo, Juliana Vilela Bastos","doi":"10.1007/s00784-024-06058-7","DOIUrl":"10.1007/s00784-024-06058-7","url":null,"abstract":"<p><strong>Aim: </strong>To describe radiographic features, clinical signs and symptoms, and chronological patterns of post-traumatic transient apical breakdown (TAB) in luxated permanent teeth.</p><p><strong>Methodology: </strong>Records from 56 patients treated at the Dental Trauma Clinic of the School of Dentistry of the Federal University of Minas Gerais from 1993 to 2024 were accessed to collect demographic, clinical, and imaging features of 89 teeth that presented with radiographic signs of TAB after traumatic dental injury (TDI). Kaplan-Meier curves were built to illustrate the time elapsed between trauma until TAB onset and resolution for the whole sample and for each one of the TAB patterns. A Cox regression was used to explore the effect of clinical covariates in both events.</p><p><strong>Results: </strong>Patients' mean age at the time of trauma was 17.7 ± 6.6 years (range 9.1 to 39.7 years), with most being male (59.6%). All included teeth were mature at the time of trauma (Moorrees stage 6). Upper central incisors (66.3%) were predominant and mostly suffered extrusions (40.4%) or lateral luxations (32.6%). TAB was observed as an expansion of the periodontal ligament associated with a \"V-shaped\" widening of the apical foramen together with apical root resorption in 45 teeth (50.6%). Expansion of the periodontal ligament associated with \"V-shaped widening of the apical foramen only was observed in 32 teeth (36%), and 12 teeth (13.5%) showed expansion of the periodontal ligament associated with apical root resorption only. The overall median time for TAB onset was 3.2 months (range, 26 days to 8 months), being significantly lower for pattern 2 (1.8 months) when compared to TAB pattern 1 and 3 (3.4, and 3.9 months) respectively (Logrank test p values < 0.001 for both comparisons). The overall median time for TAB regression was 9.1 months (range, 4.8 to 34.8 months) after trauma. Again, TAB pattern 2 presented lower periods when compared to TAB pattern 1 and 3 (Logrank test p values < 0.001 and 0.013, respectively). Color changes were not frequent neither at the time of TAB onset nor at the time of TAB resolution. However, while most teeth (53.3%) did not respond to pulp sensibility tests at the time of TAB onset, this proportion decreased to 17.6% by the time of TAB resolution.</p><p><strong>Conclusion: </strong>TAB was mainly diagnosed within four months after luxation of mature teeth, most of them being resolved within the 1-year of follow-up. The most frequent TAB pattern was an expansion of the PDL associated with a \"V-shaped\" widening of the apical foramen together with external apical root resorption.</p><p><strong>Clinical relevance: </strong>These findings represent an important contribution for treatment decision-making during the follow-up of luxated permanent teeth.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"660"},"PeriodicalIF":3.1,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738627","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive therapy for root coverage with concentrated growth factor versus platelet-rich fibrin membranes: a systematic review and bayesian network meta-analysis.","authors":"Ali Azadi, Parsa Eftekhari-Moghadam, Fazele Atarbashi-Moghadam, Parham Hazrati, Alireza Akbarzadeh Baghban, Reza Amid","doi":"10.1007/s00784-024-06063-w","DOIUrl":"10.1007/s00784-024-06063-w","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the differences between adjunctive therapy with Concentrated Growth Factor (CGF), Platelet-rich Fibrin (PRF) membranes, and available control groups in the clinical outcomes of root coverage.</p><p><strong>Materials and methods: </strong>Randomized controlled clinical trials (RCTs) were identified in Pubmed/Medline, Scopus, and ISI Web of Science databases to assess the treatments after 6 months using a Bayesian random-effect network meta-analysis (NMA) framework regarding reduction in pocket depth (PD), clinical attachment loss (CAL), recession depth (RD), and width (RW), as well as, keratinized tissue width (KTW) and thickness (KTT) gain, and complete (CRC) and mean (MRC) root coverage percentages.</p><p><strong>Results: </strong>Thirty-two RCTs were included, from which 27, 18, 12, eight, one, and one studies investigated PRF, connective tissue graft (CTG), flap alone, CGF, enamel matrix derivative (EMD), and dehydrated amniotic membrane, respectively. Thirty studies comprising CTG and flap-alone arms other than CGF and PRF were added to NMA. No significant difference has been found between CGF and PRF; however, CGF have a higher probability of being a better treatment than PRF in PD, CAL, and RW reduction and KTW gain, and PRF has a higher probability for being better in MRC, CRC, KTT gain, and RD reduction. PRF was significantly superior to flap-alone in terms of KTT gain and RD reduction. CGF had the highest probability of being the best treatment in PD and RW reduction, but in other outcomes, CTG was superior. PRF was significantly superior to flap-alone in terms of KTT gain and RD reduction.</p><p><strong>Conclusions: </strong>Both adjunctive CGF and PRF demonstrated improvements regarding root coverage outcomes. Although there is no significant difference between PRF and CGF, these two membranes might have different impacts on different outcomes. Further studies are required for a more comprehensive conclusion, especially on CGF.</p><p><strong>Clinical relevance: </strong>CTG is recommended for achieving ideal results in root coverage procedure. Since PRF and CGF both have a higher probability for being superior to flap alone, both could be suggested in cases which less than ideal outcomes are acceptable and minimization of patient discomfort is necessary.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"654"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of powder air polishing and ultrasonic scaling on the marginal and internal interface (tooth-veneer) of ceramic veneers: an in vitro study.","authors":"Florian Fuchs, Laura Antonia Mayer, Lena Unterschütz, Dirk Ziebolz, Nadia Oberueck, Ellen Schulz-Kornas, Sebastian Hahnel, Andreas Koenig","doi":"10.1007/s00784-024-06046-x","DOIUrl":"10.1007/s00784-024-06046-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the influence of prophylactic treatments and thermocycling on the marginal and internal veneering interface (tooth-veneer) as well as on the surface texture of ceramic veneers.</p><p><strong>Materials and methods: </strong>A total of 32 extracted human premolars were restored with veneers made of lithium disilicate (LDS) or zirconia-reinforced lithium silicate (ZLS). An artificial aging of the specimens was conducted via five cycles of both thermocycling (5/55°C) and prophylactic treatment (powder air polishing or ultrasonic scaling). Changes in the marginal interface and in the surface texture were examined using confocal laser scanning microscopy. The internal interface and the microstructure were investigated using micro X-ray computed tomography.</p><p><strong>Results: </strong>Artificial aging resulted in a deepening of the marginal interface across all groups (mean height: 4.51-15.74 μm, maximum height: 10.42-22.71 μm, cross-section: 256.68-1525.84 μm², regardless of the veneer material or prophylaxis method. No change in surface texture was observed. The internal interface exhibited defects for all groups after artificial aging. ZLS showed cracks in five out of eight veneers after exposure to ultrasonic scaling and thermocycling.</p><p><strong>Conclusion: </strong>Ceramic veneers exhibited a high resistance to prophylactic measures in terms of surface durability, but a deepening of the marginal interface should be taken into account. With regard to the formation of cracks within the material, the use of ultrasonic scaling is not recommended for ZLS veneers.</p><p><strong>Clinical relevance: </strong>The influence of artificial aging, including prophylactic treatments, plays a critical role in assessing longevity for veneers in defect-oriented and esthetic dentistry.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"655"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11599320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Periradicular repair after single-visit root canal treatment using sonic irrigant activation of teeth with apical periodontitis.","authors":"Nur Sena Arikan, Yelda Erdem Hepsenoglu, Seyda Ersahan, Fatih Ozcelik","doi":"10.1007/s00784-024-06059-6","DOIUrl":"10.1007/s00784-024-06059-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to explore whether using sonic irrigant activation during endodontic treatment favors periradicular repair in teeth with apical periodontitis.</p><p><strong>Materials & methods: </strong>One clinician treated 140 posterior (either premolar or molar) asymptomatic teeth with periapical lesions: 70 were randomly assigned to the sonic activation with EndoActivator (EA) group, and 70 were treated by conventional needle irrigation (CNI). Both groups underwent chemomechanical root canal preparation using 35/04 diameter rotary files and 2.5% NaOCl as the irrigant. NaOCl was sonically activated in the EA group, and the final irrigation with NaOCl was performed using a 30-gauge side-perforated needle in the CNI group. All root canal obturations were performed with lateral compaction. All patients were followed up for 12 months. Success was determined based on both healed and healing cases. The chi-square or Fisher's exact test was used to compare success rates and outcome-influencing factors between groups.</p><p><strong>Results: </strong>The recall rate was 131 (94%). At 12 months, 50 teeth (77%) were considered healed, 12 teeth (18%) as healing, and three (5%) as failed in the EA group, while 43 teeth (65%) were considered healed, 17 (26%) as healing, and six (9%) as failed in the CNI group. Verbal Rating Scale scores were significantly lower in the EA group than in the CNI group on postoperative days 1 (p < 0.0001) and 2 (p = 0.0002). Postoperative Periapical Index scores were significantly lower in the EA group than in the CNI group (p = 0.0023). Postoperative lesion sizes were also significantly smaller in the EA group (0.7 [0.2-11.7] mm) than in the CNI group (1.7 [0.5-11.5] mm; p = 0.0118). While the success rate was higher in the EA group (62 [95%]) than in the CNI group (60 [91%]), the difference was not significant (p = 0.492).</p><p><strong>Conclusions: </strong>The periradicular repair of posterior teeth with apical periodontitis demonstrated the efficacy of EndoActivator on treatment outcomes and reduced postoperative pain. These results suggest the adjunctive use of sonic activation to enhance the decontamination of the root canal system during the chemomechanical stage.</p><p><strong>Clinical relevance: </strong>This clinical trial is the first to evaluate the effects of sonic activation on postoperative healing. Sonic activation with the EndoActivator can reduce postoperative pain and accelerate the healing of the periapical tissues.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"656"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soft tissue paradigm based Treatment planning in skeletal class III.","authors":"YoungCheol Kim, Seung Il Song, Sung Hyo Lee, Hye Young Sim, Young Ho Kim, Hwa Sung Chae","doi":"10.1007/s00784-024-06062-x","DOIUrl":"10.1007/s00784-024-06062-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to propose guidelines for the indications of non-extraction, extraction camouflage treatment, and orthognathic surgery by comparing the degree of soft tissue improvement effects. This comparison focused on changes in CKHA, a soft tissue indicator corresponding to the major hard tissue indicator, ANB.</p><p><strong>Materials and methods: </strong>Sixty-six patients, 25 males and 41 females, aged between 18 and 50 years and diagnosed with skeletal Class III malocclusion (ANB < 0°), were enrolled in the study. Participants were categorized into three groups based on the treatment approach: G1, non-extraction (n = 20); G2, extraction (n = 20); and G3, orthognathic surgery (n = 26). To assess variations in treatment outcomes, measurements derived from lateral cephalometric radiographs obtained before and after treatment were analyzed and compared across the different treatment methods.</p><p><strong>Results: </strong>Significant differences were observed in the ANB between the G1 and G2/G3 groups. However, no significant differences were observed in CKHA levels after treatment. Furthermore, in G2, the CKHA approached the normal range at -1.8° (normal range: -2.0°), suggesting that soft tissue responses can normalize despite minimal changes in the skeletal structure.</p><p><strong>Conclusions: </strong>Although surgery resulted in the most significant skeletal changes, both camouflage groups demonstrated distinct advantages in the soft tissue paradigm. In G2, a noticeable posterior movement of the lower lip was observed along with a corresponding posterior shift in the soft tissue B point.</p><p><strong>Clinical relevance: </strong>This study provides guidelines for non-extraction, extraction and surgical treatment selection aimed at achieving soft tissue objectives.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"657"},"PeriodicalIF":3.1,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of RS1126478 (LTF) with molar-incisor and generalized periodontitis.","authors":"Camila S Stolf, Arthur G S Pereira, Bruna C Almeida, Hélvis E S Paz, Letícia S Arroteia, Hong Huang, Ikramuddin Aukhil, Peter Harrison, Manuela M V Miguel, Laís F F Ferraz, Mauro P Santamaria, Luciana M Shaddox, Renato C V Casarin","doi":"10.1007/s00784-024-06056-9","DOIUrl":"10.1007/s00784-024-06056-9","url":null,"abstract":"<p><strong>Objectives: </strong>LTF SNP rs1126478 (T>C) could modulate Lactoferrin function and release and has been associated with periodontal disease in different locations before, but not in America. Thus, this study aimed to assess the association between this SNP and Grade C Periodontitis (Generalized (PerioC-G) and Molar Incisor Pattern (PerioC-MIP)) and seek a relationship between its presence and LTF gingival crevicular fluid (GCF) production.</p><p><strong>Material and methods: </strong>Oral cells from 361 Brazilians and 375 North Americans patients (Diseased and Health Controls (PH) from both locations) were collected. DNA was extracted, and a prefabricated probe system determined rs116478 genotyping. Immunoenzymatic analysis detected LTF levels in GCF.</p><p><strong>Results: </strong>Higher allelic altered-C frequency was associated with PerioC. For PerioC-G, CT and CC genotypes presented a frequency of 44.7% and 34.1%, respectively, while 37.3% and 26.4% were found to PH group (OD=2.1 (p=0.004) for CT and OD=2.3 (p=0.003) for CC). PerioC-G was associated with a lower concentration (742.2±717.9 pg/ml) of LTF than PerioC-MIP (5851±5859.2 pg/ml), p<0.0001. Multiple logistic regression showed that CC genotype impacted LTF levels by acting as a predictor (β =2.457, p=0.02, OD=1.17) despite the site or diagnosis.</p><p><strong>Conclusion: </strong>There is an association of rs1126478 with Grade C periodontitis, mainly the PerioC-G. Lower LTF levels in GCF might be associated with the generalized disease pattern.</p><p><strong>Clinical relevance: </strong>This study assessed and compared the genetic background in two distinct locations, paving the way for new studies regarding personalized risk and treatment for different ethnicities. As this SNP is in a region related to the antimicrobial function of LTF, it could impact PerioC-MIP and PerioC-G response against periodontopathogens. This discovery opens the way for in vitro studies analyzing the functionality of this SNP, and, in the future, it can be used to treat PerioC, individualizing the phenotypes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"653"},"PeriodicalIF":3.1,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}