Clinical Oral Investigations最新文献

{"title":"Oral health in adolescents: periodontal inflammatory biomarkers during orthodontic clear aligner therapy.","authors":"Carolin Kredig, Eva Peuckert, Irene Schmidtmann, Thomas Drechsler, Christina Erbe","doi":"10.1007/s00784-025-06212-9","DOIUrl":"10.1007/s00784-025-06212-9","url":null,"abstract":"<p><strong>Objectives: </strong>This prospective study aimed to evaluate periodontal inflammation in adolescents undergoing orthodontic treatment with clear aligners (Invisalign® Teen, Align Technology, San Jose, CA, USA). Key objectives included assessing the presence of 11 periodontitis-associated marker bacteria, active matrix metalloproteinase-8 concentrations in sulcular fluid, and the influence of IL-1 polymorphism genotypes on periodontal health.</p><p><strong>Materials and methods: </strong>Fifty adolescent patients (13.3 ± 1.8 years) with mixed and permanent dentition participated. Gingival crevicular fluid samples were analyzed at multiple time points: before, during, and one year after aligner treatment. Periodontal health was assessed using the Gingivitis Index and the Modified Quigley-Hein Index. Genotypic analysis of IL-1 polymorphism was also performed. Statistical analyses included mixed linear models and generalized linear models to explore correlations.</p><p><strong>Results: </strong>All combinations of IL-1 polymorphism genotypes were found in the sample. No significant increase in periodontal inflammation or aMMP-8 concentrations was observed over the treatment period. Marker bacteria from the red and orange-associated complexes remained at low levels, while significant changes occurred in the orange and green complexes, particularly Capnocytophaga spp. (p = 0.0042) and Fusobacterium spp. (p = 0.0365). GI correlated significantly with aMMP-8 levels (p = 0.0017), but no genotype effect on GI was observed. MQH showed associations with pathogens from the orange and green complexes, including Capnocytophaga spp. and Fusobacterium spp.</p><p><strong>Conclusions: </strong>Clear aligner treatment in adolescents, including those with an unfavorable genotype, does not increase periodontal inflammation when accompanied by good oral hygiene.</p><p><strong>Clinical relevance: </strong>Regular periodontal monitoring and hygiene reinforcement is important during orthodontic treatment, especially in adolescent patients.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"168"},"PeriodicalIF":3.1,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143556043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional long-term assessment of soft tissue stability after orthognathic mandibular advancement for class II malocclusion correction.","authors":"Alexandre A Franco, Lucia Helena S Cevidanes, Leonardo Koerich, Luiz Carlos F Silva, Rhita Cristina C Almeida, Felipe de Assis R Carvalho, Cátia Cardoso A Quintão, Marco Antonio O Almeida","doi":"10.1007/s00784-025-06237-0","DOIUrl":"10.1007/s00784-025-06237-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to assess the stability of soft tissues one and three years after orthognathic mandibular advancement surgery by superimposing the cone-beam computed tomography (CBCT) images and quantifying potential soft tissue changes following surgery.</p><p><strong>Materials and methods: </strong>In this prospective observational study, changes in the hard and soft tissues of the chin, lower incisors, and lower lip due to displacement and/or bone remodeling were analyzed using three-dimensional models based on CBCT superimposition images acquired before surgery (T0), one year after surgery (T1), and three years after surgery (T3). The cranial base was used as a reference for the superimpositions, which were based on fully automated grayscale voxel-wise registrations.</p><p><strong>Results: </strong>The soft chin showed more than 2 mm displacement between T0 and T1 and between T0 and T3, along with hard chin displacement. The lower lip had less displacement at T0 and T1. The soft tissue adaptation between T1 and T3 indicates stability of the soft tissue correction.</p><p><strong>Conclusion: </strong>Even though the soft tissue three-dimensional response one year after surgery was variable, the investigated anatomical regions were stable between one- and three years post-surgery, and only the soft chin exhibited some relapse. The soft tissue chin changes observed were strongly correlated with the hard chin.</p><p><strong>Clinical relevance: </strong>This study provides comprehensive and long-term insights considering soft tissue facial features' stability after orthognathic surgery, impacting orthodontic treatment planning, and integrating both problem-oriented and goal-oriented approaches. The outcomes emphasize the importance of surgical aesthetics alongside occlusion, ultimately contributing to better long-term results and enhanced patient satisfaction.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"167"},"PeriodicalIF":3.1,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950625/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation between REDOX enzymes and NET markers expression during the development of periapical lesions in mice.","authors":"Clara Marina Pereira Cavalcanti Silva, Vivian Vicentin Massoni, Lisa Danielly Curcino Araujo, Ricardo Barbosa Lima, Aluísio Eustáquio de Freitas Miranda-Filho, Carolina Maschietto Pucinelli, Marília Pacífico Lucisano, Paulo Nelson-Filho, Alberto Consolaro, Raquel Assed Bezerra da Silva, Léa Assed Bezerra da Silva","doi":"10.1007/s00784-025-06246-z","DOIUrl":"10.1007/s00784-025-06246-z","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate and correlate the expression of REDOX enzymes and NET markers during the development of periapical lesions (PLs) in mice.</p><p><strong>Methods: </strong>PLs were experimentally induced by pulpal exposure of first molars. In all, 42 mice were involved in a negative control and five periods (after 2, 5, 7, 21 and 42 days) (n = 7 in each period). Microscopic analysis of the specimens was carried out, considering inflammatory response and the PL area (mm²). In addition, qRT-PCR (genes) and immunohistochemistry assay (proteins) were performed for REDOX enzymes (NOS2, SOD1, CAT, and GSR) and NET markers (MPO, H3CIT, and ELANE). The significance level was set at 5%.</p><p><strong>Results: </strong>Pulpal exposure led to the formation of PLs, especially after 21 and 42 days, when there was significantly increased bone resorption compared to previous periods (P < 0.001). There was an increased expression of all REDOX enzymes, as well as MPO and H3CIT markers after pulpal exposure in at least one time point in relation to the negative control, especially after 5 days (P = 0.002 or less). NOS2, SOD1, ELANE and H3CIT were significantly correlated with the PL area (P < 0.05). In addition, there was also a correlation between REDOX enzymes and NET markers (P < 0.05), such as all REDOX enzymes with H3CIT, CAT and GSR with MPO, and CAT and GSR with ELANE (P < 0.05).</p><p><strong>Conclusions: </strong>Pulpal exposure modified the expression of REDOX enzymes and NET markers throughout the development of PLs, as well as some of these enzymes and markers were correlated, which may suggest the association of different molecular pathways.</p><p><strong>Clinical relevance: </strong>The association between REDOX activity and NETs, including their molecular signaling, may modify the development of PLs after pulpal exposure and should be investigated as a possible therapeutic target in periapical bone repair.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"166"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and radiographic outcomes of mini-implant-retained maxillary and mandibular overdentures: a systematic review and meta-analysis.","authors":"Morteza Mohammadi, Emad Baker, Bruno Ramos Chrcanovic","doi":"10.1007/s00784-025-06242-3","DOIUrl":"10.1007/s00784-025-06242-3","url":null,"abstract":"<p><strong>Objective: </strong>To assess the clinical and radiographic outcomes of overdentures and their retaining dental mini-implants, based on a single-arm systematic literature review.</p><p><strong>Methods: </strong>Electronic search was undertaken in three databases, last updated in October 2023, plus manual search of journals. Cumulative implant survival rate (CSR) and the estimated marginal bone loss (MBL) under different follow-up times were calculated.</p><p><strong>Results: </strong>Thirty-nine studies were included, with 3,787 mini-implants supporting 1,026 overdentures (109 maxilla, 896 mandible) in 1,005 patients, with a mean follow-up of 28.1 ± 19.8 months (min-max 0.3-84.0). 202 mini-implants failed, after a mean of 9.4 ± 11.8 months (7-year CSR 91.4%). The implant survival was lower in the maxilla in comparison to the mandible (p < 0.001), lower for early/delayed-loaded in comparison to immediately-loaded implants (p = 0.005) and lower for 2-mini-implant in comparison to 4-mini-implant-retained mandibular overdenture (p < 0.001; Log-rank test). A high rate of transversal fracture of the prosthesis and wear of the attachment parts was observed. The estimated mean MBL gradually increased from 0.518 (≤ 6 months) to 1.260 mm (58.8-90 months). There was an estimated MBL increase of 0.011 mm per additional month of follow-up.</p><p><strong>Conclusion: </strong>Although presenting a high 7-year CSR, mini-implant-retained overdentures may require frequent maintenance follow-ups, due to the high rate of technical complications. The estimated MBL of mini-implants over 80 months is low.</p><p><strong>Clinical relevance: </strong>The ability to anticipate outcomes is an essential part of risk management in clinical practice. The findings reported herein set some recommendations and potential strategies for minimizing failures and complications commonly associated with this mini-implant-retained overdentures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"164"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11872979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of an experimental pregabalin gel on dental sensitivity and color change after bleaching with 35% hydrogen peroxide: a randomized clinical trial.","authors":"Gabriela Monteiro Barbosa Xavier, Yngrid Fernanda Oliveira Paes, Lindalva Maria de Meneses Costa Ferreira, Maria Louze Nobre Lamarão, Cecy Martins Silva, Roseane Maria Ribeiro-Costa, Jesuina Lamartine Nogueira Araújo","doi":"10.1007/s00784-025-06168-w","DOIUrl":"10.1007/s00784-025-06168-w","url":null,"abstract":"<p><strong>Objective: </strong>This clinical study evaluated an experimental pregabalin (PG) gel in reducing dental sensitivity (DS) and color change after dental bleaching.</p><p><strong>Materials and methods: </strong>Seventy-five volunteers were selected and randomized into three groups: GPG (10% pregabalin gel), GKF (5% potassium nitrate and 2% sodium fluoride), and GP (placebo gel). Prior to the bleaching treatment, GPG and GKF received applications of the respective desensitizing gels for 10 min. The GP group received an application of placebo gel, similar to the other groups. The bleaching was performed with 35% hydrogen peroxide in 3 sessions, with a 7-day interval between sessions. Post-bleaching DS was assessed using the visual analog scale (VAS) over 21 days of follow-up. Color Assessment (ΔE00, ΔWID, and ΔEab) and luminosity (L) were measured at baseline (T0) and 7 days after the third session (T1). Friedman, Kruskal-Wallis, one-way ANOVA, and Tukey tests were used, with α = 5%.</p><p><strong>Results: </strong>Intergroup analysis showed that on the 1st, 8th, and 15th days, DS was higher for GP (p < 0.006; p = 0.004; p < 0.001) and did not differ between GKF and GPG (p = 0.203; p = 0.178; p = 0.09). In the intragroup analysis, GP showed a significant increase in DS on the 15th day (p < 0.001).</p><p><strong>Conclusions: </strong>The experimental 10% pregabalin gel reduced dental sensitivity and did not interfere with bleaching results.</p><p><strong>Clinical significance: </strong>The topical application of 10% pregabalin gels and NKF was effective in reducing tooth sensitivity 24 hoursafter whitening with 35% hydrogen peroxide.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov trial registry with the identifier NCT06180707.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"165"},"PeriodicalIF":3.1,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143536891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of different dental scenarios on the accuracy of computerized optical impressions: an in vitro pilot study.","authors":"Babak Saravi, Clemens L Paffenholz, Derek Hazard, Ralf J Kohal, Sebastian B M Patzelt","doi":"10.1007/s00784-025-06245-0","DOIUrl":"10.1007/s00784-025-06245-0","url":null,"abstract":"<p><strong>Objectives: </strong>This in vitro study aimed to determine the influence of various dental scenarios on the accuracy of computerized optical impressions (COIM), specifically focusing on trueness and precision.</p><p><strong>Materials and methods: </strong>Eight resin casts representing different dental scenarios, including fully dentate upper (UU) and lower jaws (UL), full-arch preparation (FA), single abutment preparations (SA), anterior (AB) and lateral bridge preparations (LB), partial crown preparations (PA), and veneer preparations (VE), were digitally captured using an extraoral reference scanner and an intraoral scanner. The datasets from both scanners were superimposed to calculate and statistically evaluate three-dimensional mean deviations.</p><p><strong>Results: </strong>The accuracy of maxillary full-arch scans was lowest in the PA scenario (trueness: 34.18 ± 5.46 μm, precision: 36.0 ± 14.69 μm) and LB scenario (trueness: 33.18 ± 7.86 μm, precision: 47.70 ± 14.09 μm). The best accuracy was observed in the SA (trueness: 21.38 ± 1.87 μm, precision: 22.25 ± 4.31 μm) and FA (trueness: 23.75 ± 1.51 μm, precision: 15.26 ± 3.41 μm) scenarios, significantly better than UU (trueness: 29.67 ± 0.79 μm, precision: 29.51 ± 1.17 μm). Soft tissue included in the scans of UU and UL lowered accuracy.</p><p><strong>Conclusions: </strong>The accuracy of COIM varies significantly with different dental scenarios. Scenarios with extensive edentulous areas and complex preparation designs exhibit lower accuracy.</p><p><strong>Clinical relevance: </strong>Accurate dental impressions are vital for the proper fit of prosthetic restorations. This study highlights that scenarios with less edentulous areas and simpler preparation designs yield better accuracy. Clinicians should be mindful that large edentulous areas and complex preparations can pose challenges for intraoral scanners, requiring careful scanning strategies to mitigate potential inaccuracies.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"162"},"PeriodicalIF":3.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of single-implant mandibular overdenture on the pattern of denture uses and patient-reported outcomes: a 2-year prospective study.","authors":"Aretha Heitor Verissimo, Anne Kaline Claudino Ribeiro, Daniel Mariano Sousa Silva, Euler Dantas Maciel, Claudio Rodrigues Leles, Adriana da Fonte Porto Carreiro","doi":"10.1007/s00784-025-06190-y","DOIUrl":"10.1007/s00784-025-06190-y","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the effect of single-implant mandibular overdenture (SIMO) on the patterns of denture use after the transition to overdenture treatment and the changes in patient-reported outcomes (PROMs) throughout a 2-year follow-up.</p><p><strong>Materials and methods: </strong>Complete denture was provided to edentulous patients and the pattern of denture use was assessed after an adaptive period of 3 months after denture delivery and post-insertion care. Then, patients were invited to SIMO treatment. For those who accepted implant treatment, a single morse taper implant was inserted in the mandibular midline and loaded after four months using an O'ring-ball attachment. The pattern of denture use, patient satisfaction, and oral health-related quality of life impacts (OHRQoL) were assessed at the pre-and up to 2-year post-treatment follow-up. Data analyses included regression analysis for longitudinal data using Generalized Estimating Equations (GEE).</p><p><strong>Results: </strong>Conventional dentures were provided to 58 patients, and 25 underwent SIMO treatment. At baseline assessment, 13 patients (52%) presented poor adaptation and discontinuous use of the mandibular denture. At the 3-month follow-up after the delivery of SIMO, there was a significant reduction in the impacts on OHRQoL and a notable improvement in patient satisfaction, which remained unaltered throughout the 2-year assessments. Treatment benefits were more pronounced for patients poorly adapted to the mandibular denture (p < 0.05). All patients showed continuous use of the mandibular denture after conversion to a SIMO.</p><p><strong>Conclusions: </strong>SIMO significantly improves PROMs and positively changes the pattern of denture use in patients who are poorly adapted to the conventional mandibular denture. Immediate changes were sustained after two years of SIMO use.</p><p><strong>Clinical relevance: </strong>The delayed loaded SIMO markedly improved patient satisfaction with the mandibular denture and reduced OHRQoL impacts. It also shifted patients with discontinuous use into continuous users after the transition to overdenture treatment. SIMO can be a minimally invasive and less costly alternative for patients struggling with uncomfortable conventional mandibular dentures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"163"},"PeriodicalIF":3.1,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143522873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal adaptation analysis of CAD/CAM resin crown with non-invasive methods.","authors":"Chen Zeng, Tomoko Tabata, Rena Takahashi, Masaomi Ikeda, Junichi Shinagawa, Hisaichi Nakagawa, Yumi Tsuchida, Shunsuke Takano, Yasunori Sumi, Yasushi Shimada","doi":"10.1007/s00784-025-06215-6","DOIUrl":"10.1007/s00784-025-06215-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study compared the silicone replica method with swept-source optical coherence tomography (SS-OCT) to analyze marginal adaptation and investigated the effect of the light incidence angle of SS-OCT on measurement precision.</p><p><strong>Materials and methods: </strong>A typodont-prepared mandibular right first molar was scanned using an intraoral scanner (Trios 3). Fourteen crowns were fabricated from CAD/CAM resin blocks (Katana Avencia P) using a 5-axis milling machine (DWX-50). Marginal adaptation at the buccal, lingual, mesial, and distal points was assessed using the silicone replica method and SS-OCT at light incidence angles of 60°, 75°, and 90°. Statistical comparisons were performed using two-way analysis of variance (ANOVA) and t-tests with Bonferroni correction, and t-tests at a significance level of 0.05.</p><p><strong>Results: </strong>At 60°, SS-OCT showed significantly larger marginal discrepancies than the silicone replica method at the buccal, lingual, and mesial points (p < 0.05). At 75°, only the lingual point showed a significantly larger value than the silicone replica method (p < 0.05). At 90°, no significant differences were observed between the SS-OCT and silicone replica methods (p > 0.05). Marginal discrepancy values increased as the angle changed from 90° to 75° to 60°, with significant differences between 60° and 75° and between 60° and 90° at the buccal and lingual points (p < 0.05).</p><p><strong>Conclusions: </strong>SS-OCT is a viable alternative to the silicone replica method for assessing marginal adaptation at an incidence angle of 90 °.</p><p><strong>Clinical relevance: </strong>SS-OCT, a non-invasive method, has the potential to be applied clinically for evaluating marginal fit in indirect restorations in vivo.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"158"},"PeriodicalIF":3.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of volumetric and surface stability of calcium silicate-based repair cements at different pHs.","authors":"Ana Cristina Padilha Janini, Débora Leticia Bittencourt Leite Alves, Victor Augusto Benedicto Dos Santos, Brenda Fornazaro Moraes, Nilvan Alves da Silva, Matheus Barros-Costa, Luciano Augusto Cano Martins, Francisco Haiter Neto, Marina Angélica Marciano","doi":"10.1007/s00784-025-06232-5","DOIUrl":"10.1007/s00784-025-06232-5","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this research was to evaluate the volumetric and surface stability in vitro, to different pH levels, of calcium silicate-based repair cements ready-to-use and powder/liquid exposed.</p><p><strong>Materials and methods: </strong>Sixty human teeth were retro-prepared to a depth of 3 mm and divided into two groups. The first group included powder/liquid cements Biodentine (Septodont, France) and MTA HP (Angelus, Brazil); the second group included ready-to-use cements Bio-C Repair (Angelus, Brazil) and ENDOCEM MTA (Maruchi, Republic of Korea). All samples were submerged in PBS solution with pH levels of 5, 7, and 12. Initially, the materials were evaluated for porosity, marginal adaptation, and volumetric change using micro-CT, and then re-evaluated after 7 and 30 days of exposure to PBS solution. The samples were characterized using SEM/EDS and RAMAN spectroscopy. Statistical evaluation was performed using ANOVA with a 5% significance level.</p><p><strong>Results: </strong>Bio-C Repair showed significant statistical differences (p < 0.05) at different pHs in 7 and 30 days compared to other materials, being greater in acidic medium. ENDOCEM, regardless of pH, at 30 days showed fewer voids when compared to other repair cements.</p><p><strong>Conclusion: </strong>This micro-CT study demonstrated that regardless pH, the clinic presentation of calcium silicate-based materials ready-to-use showed higher and loss volumetric than powder/liquid materials at 30 days.</p><p><strong>Clinical relevance: </strong>Under neutral pH conditions, calcium silicate-based materials are expected to maintain properties such as bioactivity and low solubility. However, in clinical situations involving infection and inflammation, pH variations can impact the physicochemical properties of these materials regardless of their clinical presentation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"160"},"PeriodicalIF":3.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Are dental professionals aware of the discovery of newly identified salivary glands? Is there a debate about this discovery?","authors":"Ahmet Eren Karabıyık, Tuna Sumer, Kübra Çam, Sibel Uçak Semirgin, Ayşe Zeynep Zengin","doi":"10.1007/s00784-025-06228-1","DOIUrl":"10.1007/s00784-025-06228-1","url":null,"abstract":"<p><strong>Aim: </strong>Writing a letter to the editor.</p><p><strong>Background: </strong>Saliva plays a crucial role in chewing, swallowing, digestion, taste, and oral hygiene. In addition to the three major salivary glands in humans (parotid, submandibular, and sublingual glands), the existence of small salivary glands scattered in the submucosa of the nasopharynx and oropharynx is also known.</p><p><strong>Material and methods: </strong>Is it a new organ? This discovery has attracted significant attention from the scientific community but has also raised questions and sparked debates. Should the tubarial glands be classified as major or minor salivary glands, or as a separate organ? For a structure to be classified as an organ, it must have a distinct shape and structure, consist of multiple tissue types, and perform specific functions.</p><p><strong>Conclusion: </strong>As we know, the definition and recognition of an organ must be based on scientific foundations. More research is needed on tubarial glands, and it seems that this discussion will continue for some time. Our purpose in writing this letter is to raise awareness of this issue among dental professionals.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"161"},"PeriodicalIF":3.1,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}