Clinical Oral Investigations最新文献

{"title":"Autologous platelet concentrates as adjuncts to non-surgical periodontal therapy: a systematic review and meta-analysis.","authors":"Tina Lipovec, N Kapadia, G N Antonoglou, E M C Lu, K M Fawzy El-Sayed, Luigi Nibali","doi":"10.1007/s00784-024-06128-w","DOIUrl":"10.1007/s00784-024-06128-w","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the possible additional clinical benefit from autologous platelet concentrate (APC) treatment adjunct to non-surgical periodontal therapy (NSPT).</p><p><strong>Methods: </strong>Electronic (MEDLINE/Embase/Cochrane/MedNar/CORE) and hand searches were conducted. Following studies selection, evidence tables were formed, and meta-analyses were performed for the following outcomes: probing pocket depth (PPD) reduction, clinical attachment level (CAL) gain, and bleeding on probing (BoP) reduction. The protocol for this systematic review was registered in PROSPERO (CRD42023514388).</p><p><strong>Results: </strong>After de-duplication, the initial search yielded 194 citations, from which ten papers were eligible for quantitative synthesis. The APC group comprised 270 patients, while the control group included 230. The meta-analysis revealed that a single APC application resulted in a 0.6 mm greater PPD reduction (MD = -0.62; 95% CI: -1.03, -0.22) and 0.8 mm more CAL gain (MD = -0.77; 95% CI: -1.18, -0.37) at the 6-12 weeks follow-up. At six months, the APC group exhibited a 0.6 mm greater PPD reduction (MD = -0.61; 95% CI: -1.13, -0.09) and 1.1 mm more CAL gain (MD = -1.14; 95% CI: -1.94, -0.34) compared to the NSPT only group. In contrast, BoP indices did not reveal a statistically significant difference between the groups after 6-12 weeks (MD = -10.54; 95% CI: -25.21, 4.14). High heterogeneity and unclear to high risk of bias were detected.</p><p><strong>Conclusion: </strong>Over six months, the adjunctive APC use appears to provide additional benefits in PPD reduction and CAL gain compared to NSPT alone.</p><p><strong>Clinical relevance: </strong>The adjunctive use of APCs seems to promote further improvements in clinical outcomes following NSPT.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"74"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754314/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The influence of anorexia nervosa on oral health and related parameters potentially relevant to orthodontic treatment: a systematic review and meta-analysis.","authors":"Christian Niederau, Eda Alman, Marta Rizk, Kathrin Becker, Nikolaus Marx, Franziska A Coenen, Isabel Knaup, Michael Wolf, Rogerio Bastos Craveiro","doi":"10.1007/s00784-024-05774-4","DOIUrl":"10.1007/s00784-024-05774-4","url":null,"abstract":"<p><strong>Objectives: </strong>Information on the oral health of patients with anorexia nervosa remains not satisfactory. The aim of this systematic review is to evaluate oral health parameters in anorexic patients compared to healthy individuals. Furthermore, potential clinical implications for orthodontic treatment are discussed from an orthodontic perspective.</p><p><strong>Materials and methods: </strong>Electronic databases were searched for case-control and controlled clinical trial studies on dentofacial manifestations in anorexic patients up to 2/2024. Study selection, data extraction and risk of bias assessment was done independently by two authors. Random-effects meta-analyses of mean differences (MDs) or relative risks (RRs) with their 95% confidence intervals (CIs) were conducted, followed by sensitivity analyses.</p><p><strong>Results: </strong>Eleven out of 573 initially identified studies were included. They involved oral health analyses of general anorexic patients ≥ 12 years (mean age 18.4). The meta-analysis showed that anorexia nervosa was associated with a significantly increased caries experience (DMFT), plaque accumulation and gingival inflammation (BOP). PH and salivary flow rate were significantly altered in patients with anorexia nervosa, although no significant relationship between α-amylase levels and anorexia nervosa was demonstrated.</p><p><strong>Conclusions: </strong>These data enabled us to formulate modalities for anorexia-specific orthodontic treatments. Based on the results, patients with anorexia nervosa exhibit an increased risk of caries and gingival inflammatory signs.</p><p><strong>Clinical relevance: </strong>The systematic information on dentofacial manifestations obtained in this study should be considered to better manage the oral health of anorexia patients.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"76"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of pain-related long non-coding RNAs for pulpitis prediction.","authors":"Yongjie Tan, Ying He, Yuexuan Xu, Xilin Qiu, Guanru Liu, Lingxian Liu, Ye Jiang, Mingyue Li, Weijun Sun, Ziqiang Xie, Yonghui Huang, Xin Chen, Xuechao Yang","doi":"10.1007/s00784-025-06164-0","DOIUrl":"10.1007/s00784-025-06164-0","url":null,"abstract":"<p><strong>Objectives: </strong>We investigated the recently generated RNA-sequencing dataset of pulpitis to identify the potential pain-related lncRNAs for pulpitis prediction.</p><p><strong>Materials and methods: </strong>Differential analysis was performed on the gene expression profile between normal and pulpitis samples to obtain pulpitis-related genes. The co-expressed gene modules were identified by weighted gene coexpression network analysis (WGCNA). Then the hypergeometric test was utilized to screen pain-related core modules. The functional enrichment analysis was performed on the up- and down-regulated genes in the core module of pulpitis pain to explore the underlying mechanisms. A pain-related lncRNA-based classification model was constructed using LASSO. Consensus clustering and gene set variation analysis (GSVA) on the infiltrating immunocytes was used for pulpitis subtyping. miRanda predicts miRNA-target relationship, which was filtered by expression correlation. Hallmark pathway and enrichment analysis was performed to investigate the candidate target pathways of the lncRNAs.</p><p><strong>Results: </strong>A total of 1830 differential RNAs were identified in pulpitis. WGCNA explored seven co-expressed modules, among which the turquoise module is pain-related with hypergeometric test. The up-regulated genes were significantly enriched in immune response related pathways. Down-regulated genes were significantly enriched in differentiation pathways. Eight lncRNAs in the pain-related module were related to inflammation. Among them, MIR181A2HG was downregulated while other seven lncRNAs were upregulated in pulpitis. The LASSO classification model revealed that MIR181A2HG and LINC00426 achieved outstanding predictive performances with perfect ROC-AUC score (AUC = 1). We differentiated the pulpitis samples into two progression subtypes and MIR181A2HG is a progressive marker for pulpitis. The miRNA-mRNA-lncRNA regulatory network of pulpitis pain was constructed, with GATA3 as a key transcription factor. NF-kappa B signaling pathway is a candidate pathway impacted by these lncRNAs.</p><p><strong>Conclusions: </strong>PCED1B-AS1, MIAT, MIR181A2HG, LINC00926, LINC00861, LINC00528, LINC00426 and ITGB2-AS1 may be potential markers of pulpitis pain. A two-lncRNA signature of LINC00426 and MIR181A2HG can accurately predict pulpitis, which could facilitate the molecular diagnosis of pulpitis. GATA3 might regulate these lncRNAs and downstream NF-kappa B signaling pathway.</p><p><strong>Clinical relevance: </strong>This study identified potential pain-related lncRNAs with underlying molecular mechanism analysis for the prediction of pulpitis. The classification model based on lncRNAs will facilitate the early diagnosis of pulpitis.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"75"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the influence of connection configuration on the implant-abutment interface vertical misfit of original milled titanium and laser-sintered cobalt-chromium abutments.","authors":"Pedro Diaz, Beatriz Vizoso, Carlos Lopez-Suarez, Esther Gonzalo, Seyed Ali Mosaddad, Maria J Suarez","doi":"10.1007/s00784-024-06093-4","DOIUrl":"10.1007/s00784-024-06093-4","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the vertical misfit at the implant-abutment interface in external and internal connections across various implant brands, comparing original milled titanium abutments with laser-sintered cobalt-chromium (Co-Cr) abutments.</p><p><strong>Materials and methods: </strong>A total of 160 implants from four different brands were utilized, with 80 featuring external connections (EC) and 80 internal connections (IC). Original milled titanium abutments (n = 160) and Co-Cr laser-sintered abutments (n = 160) were randomly attached to each connection type, following the manufacturer's recommended torque. After undergoing thermal cycling, the vertical misfit was measured using a scanning electron microscope. Statistical analyses were performed using the Kruskal-Wallis and Mann-Whitney U tests. The significance level was set at α = 0.05.</p><p><strong>Results: </strong>The original milled titanium abutments exhibited the lowest misfit values. Significant differences were identified between both abutment types for EC (d = 109.578 μm; p = 0.0001) and IC (d = 44.317 μm; p = 0.002). The EC with laser-sintered abutments demonstrated the highest marginal misfit values, with an average of nearly 30 μm, while a misfit value of 11.382 μm was achieved in the IC. Differences were observed among the brands for milled abutments in both EC and IC. Similarly, variations were also noted for the laser-sintered Co-Cr abutments in EC and IC configurations.</p><p><strong>Conclusions: </strong>The vertical misfit of the original milled titanium abutments in all groups was within the clinically acceptable range for IC. The connection type significantly impacted the vertical misfit in laser-sintered Co-Cr abutments. Differences among the implant systems were observed for both connection types and abutment types evaluated.</p><p><strong>Clinical relevance: </strong>Using original milled titanium abutments, particularly in internal connection systems, can lead to better fit and stability at the implant-abutment interface, potentially reducing the risk of mechanical complications and improving long-term implant success.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"72"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and imaging aspects associated with persistent apical periodontitis: subsides for the treatment decision-making process.","authors":"Igor Bassi Ferreira Petean, Hugo Gaêta-Araujo, Jardel Francisco Mazzi-Chaves, Alice Correa Silva-Sousa, Fabiane Carneiro Lopes-Olhê, Francisco Wanderley Garcia de Paula-Silva, Manoel Damião de Sousa-Neto","doi":"10.1007/s00784-024-06132-0","DOIUrl":"10.1007/s00784-024-06132-0","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate cases of persistent apical periodontitis (PAP) and what are the imaging and clinical aspects that could be considered in the PAP diagnosis and in their treatment decision-making process.</p><p><strong>Methodology: </strong>423 patients with apical periodontitis at the time of non-surgical root canal treatment (NSRCT) were followed-up for at least 1 year. Periapical radiographic images were used to compare and determine periapical status at each time using the PAI scoring system. Cases scored as PAI 5 at the follow-up appointment were evaluated by CBCT, using the CBCTPAI scoring system. Associated, the data from imaging exams and from clinical evaluation were considered to make a decision for PAP treatment.</p><p><strong>Results: </strong>Regarding sample composition, it was observed an association with ethnicity and PAP (p = 0.045). After follow-up, cases classified as PAI Score 1 and 2 and absence of symptoms/complaint were classified as successful. Cases classified as PAI Score 3 and absence of symptoms/complaint were referred for new follow-up visits until complete resolution of PAP. Cases scored as PAI 4 with clinical symptoms were indicated for non-surgical root canal retreatment. Cases scored as PAI 5 were assessed by CBCT, and in the presence of symptoms/complaint and a CBCTPAI score 3 were related to non-surgical root canal retreatment, while CBCTPAI scores 4 and 5 were refereed for endodontic surgery.</p><p><strong>Conclusions: </strong>Clinical data, PAI and CBCTPAI scoring systems from image exams can be useful for PAP diagnosis and their treatment.</p><p><strong>Clinical relevance: </strong>In the decision-making process, clinical and imaging data are fundamental for the choose of an ideal protocol for treating PAP.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"71"},"PeriodicalIF":3.1,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of nanostructured additives in tooth bleaching agents on enhancing color change and reducing side effects: a scoping review.","authors":"Patrick Wesley Marques de Boa, Kaiza de Sousa Santos, Aleph Matthews da Silva Souza, Arnóbio Antônio da Silva-Júnior, Boniek Castillo Dutra Borges","doi":"10.1007/s00784-025-06148-0","DOIUrl":"10.1007/s00784-025-06148-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine whether incorporating nanostructured additives into bleaching agents enhances efficacy and reduces side effects while identifying gaps for further investigation.</p><p><strong>Methods: </strong>A comprehensive search was conducted in electronic databases, including PubMed/Medline, Embase, Scopus, and ISI Web of Science. Two reviewers independently screened articles based on predefined criteria, resolving discrepancies through discussion or consultation with a third reviewer. Data extraction focused on key details, including study design, interventions, and outcomes.</p><p><strong>Results: </strong>Twenty-one articles were reviewed, consisting of nine clinical studies, one in vivo/in situ study, and 11 in vitro studies on tooth bleaching protocols. Hydrogen peroxide was the most commonly used bleaching agent. The primary nanostructured additives studied were titanium dioxide nanoparticles, polymeric carbamide peroxide nanoparticles, chitosan nanoparticles, nano-hydroxyapatite, SiO2/MgO/Fe2O3 nanocomposite spheres, and nano-bioactive glass. Most studies demonstrated an enhanced bleaching effect, reduced bleaching sensitivity, decreased cytotoxicity, reduced hydrogen peroxide penetration into the pulp chamber, and protection of the tooth surface against mineral and structural loss when nanostructured additives were incorporated into the bleaching agent.</p><p><strong>Conclusions: </strong>Incorporating nanostructured additives into tooth-bleaching agents improved efficacy and reduced side effects, especially with titanium oxide nanoparticles. Further clinical studies and systematic reviews are needed to establish strong evidence for safe clinical practice.</p><p><strong>Clinical relevance: </strong>Including nanostructured additives in bleaching agents, such as titanium oxide nanoparticles, might be a valuable approach to enhancing the bleaching potential while reducing bleaching sensitivity and cytotoxicity, offering safer alternatives for clinical protocols.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"70"},"PeriodicalIF":3.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Application of orthodontic force in autotransplanted teeth: a longitudinal study.","authors":"Emma Declerck, Mostafa EzEldeen, Jan Wyatt, Giacomo Begnoni, Guy Willems, Reinhilde Jacobs, Steffen Fieuws, Maria Cadenas de Llano-Pérula","doi":"10.1007/s00784-024-06106-2","DOIUrl":"10.1007/s00784-024-06106-2","url":null,"abstract":"<p><strong>Objectives: </strong>To longitudinally follow up a cohort of patients with autotransplanted teeth, assessing how the timing of starting orthodontic treatment impacts root length.</p><p><strong>Materials and methods: </strong>Patients under 18 with at least one open-apex autotransplanted premolar (AP) replaced to a central incisor position were included. Root/crown ratio (RCR) was calculated on periapical radiographs taken at intervals of 3-6 months after transplantation. The RCR of AP in patients without orthodontic treatment and patients where orthodontic treatment was initiated at different time points (3,6,9,12,18 months) were compared.</p><p><strong>Results: </strong>52 autotransplanted premolars were included and 315 peri-apical radiographs were collected. The median timespan between autotransplantation and the start of orthodontic force (OF) application was 8.5 (IQR 2-23) months, with a mean follow-up period of 32 (IQR 9-46) months. Early OF post-autotransplantation correlated with early stagnation of root development. When OF was delayed, AP tended to show more root lengthening. Delayed OF was linked to a higher incidence of External Apical Root Resorption (EARR) once forces were introduced, ultimately resulting in root lengths comparable to those with early OF. The presence or absence of OF is the factor most notably influencing the final root length of AP.</p><p><strong>Conclusions: </strong>The timing of OF application did not compromise the final root length of autotransplanted teeth. Early OF to prevent ankylosis is feasible without affecting root length. Future research should utilize 3D imaging to provide a deeper understanding of orthodontic treatment's effects on autotransplanted teeth.</p><p><strong>Clinical relevance: </strong>The study underscores the importance of tailored orthodontic intervention timing in autotransplanted teeth, balancing early force application to avoid ankylosis against the risk of EARR.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"69"},"PeriodicalIF":3.1,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143000911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome and its effect on immune cells in apical periodontitis- a narrative review.","authors":"Yi Zhu, Annie Shrestha","doi":"10.1007/s00784-025-06161-3","DOIUrl":"10.1007/s00784-025-06161-3","url":null,"abstract":"<p><strong>Objectives: </strong>Apical periodontitis (AP) is an inflammatory immune response in periapical tissues caused by microbial infections. Failure of root canal treatment or delayed healing is often due to intracanal or extra-radicular bacteria. However, beyond microbial factors, the patient's systemic health can significantly influence the progression and healing of AP. Metabolic syndrome is a risk factor and it is characterized by a cluster of interconnected metabolic risk factors, including abdominal obesity, hyperlipidemia, hypertension, and hyperglycemia.</p><p><strong>Materials and methods: </strong>A comprehensive literature review was conducted on apical periodontitis and metabolic syndrome, and their impact on the roles of different immune cell populations.</p><p><strong>Results: </strong>Both AP and metabolic syndrome are inflammatory diseases that involve complex and interwoven immune responses. The affected immune cells are categorized into the innate (neutrophils, macrophages, and dendritic cells) and adaptive immune systems (T cells and B cells).</p><p><strong>Conclusions: </strong>Metabolic diseases and AP are closely correlated, possibly intertwined in a two-way relationship driven by a shared dysregulated immune response.</p><p><strong>Clinical relevance: </strong>Understanding the pathophysiology and immune mechanisms underlying the two-way relationship between metabolic syndrome and AP can help improve treatment outcomes and enhance the overall well-being of patients with endodontic disease complicated by metabolic syndrome.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"67"},"PeriodicalIF":3.1,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influences of patient positioning and general anesthesia on condylar position and surgical accuracy in orthognathic surgery.","authors":"Dirk-Melle Beek, Bo Berends, Frank Baan, Jeroen Liebregts, Kasper Stokbro, Tong Xi","doi":"10.1007/s00784-024-06055-w","DOIUrl":"10.1007/s00784-024-06055-w","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the effect of patient positioning and general anesthesia on the condylar position in orthognathic surgery.</p><p><strong>Materials and methods: </strong>This prospective study included patients undergoing orthognathic surgery between 2019 and 2020. Four weeks prior to surgery (T0) cone-beam computed tomography (CBCT) scans and intra-oral scans (IOS) were acquired in an upright position. Additionally, two IOS were acquired in the operating theatre, one before (T1) and one after (T2) general anaesthesia in supine position. The condylar position was analysed by matching the mandible from CBCT data with IOS at T1, T2 and T3, calculating the spatial differences at the level of lateral condylar points.</p><p><strong>Results: </strong>Based on 32 patients, patient positioning and general anesthesia on condylar position significantly affected condylar position. In supine position, the condyles moved primarily in the cranial direction by 0.94 ± 0.92 mm (p < 0.01). After anesthesia, the condyles moved posteriorly by 0.20 ± 0.45 mm (p = 0.02). These changes in condylar position resulted in the occlusal plane of the mandible being positioned more cranially (2.31 ± 2.61 mm; p < 0.01), anteriorly (0.70 ± 1.32 mm; p = 0.04), and counterclockwisely pitched (-1.42 ± 2.25°; p = 0.02).</p><p><strong>Conclusion: </strong>The present study demonstrated that both supine position and general anesthesia significantly influenced the condylar position, the mandibular position, and, subsequently, the surgical accuracy of orthognathic surgery.</p><p><strong>Clinical relevance: </strong>Surgeons should take these effects into consideration when planning orthognathic surgery as this might lead to under- or overcorrections.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"68"},"PeriodicalIF":3.1,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The clinical effect of bone perforations in periodontal regeneration and alveolar socket preservation: a systematic review with meta-analysis.","authors":"Paolo Pesce, Luigi Canullo, Tiziano Testori, Alessandro Mastroianni, Massimo Del Fabbro, Maria Menini","doi":"10.1007/s00784-025-06152-4","DOIUrl":"10.1007/s00784-025-06152-4","url":null,"abstract":"<p><strong>Objectives: </strong>The present systematic review aimed to evaluate if cortical bone perforation is effective in enhancing periodontal surgery and guided bone regeneration (GBR) in humans.</p><p><strong>Materials and methods: </strong>Electronic search was performed in PubMed, Scopus and Cochrane CENTRAL up to October 31st, 2023. Grey literature was also searched. Prospective controlled studies were included. Two PICO questions were created; one focusing on the effect of bone perforation in the treatment of peridodontal intrabony defects (primary outcome probing depth (PD)) and one focusing on the effect of bone perforation in guided bone regeneration (primary outcome: histologic and histomorphometric data). The risk of bias of the included studies was assessed using the Cochrane tool for randomized controlled studies (RCTs) and the Joanna Briggs Institute Critical Appraisal tool for cohort studies. Pairwise meta-analysis was undertaken when possible, to estimate the overall effect for the outcomes investigated.</p><p><strong>Results: </strong>The search on databases yielded a total of 653 articles. After screening, five RCTs and one non-randomized study were included. A meta-analysis was performed for the first PICO. PD was evaluated in 4 articles and no significant difference was found between the perforation vs. no perforation groups (0.11 mm (95% CI [-0.14 to 0.37 mm], P = 0.38). Additionally, radiographic defect depth (mean difference 0.77 mm, 95% CI [0.24 to 1.30 mm], P = 0.004) and distance between cemento-enamel junction and bone defect (standardized mean difference 0.98 mm, 95% CI [0.47 to 1.50 mm], P = 0.0002) resulted improved in the cortical bone perforation group.</p><p><strong>Conclusion: </strong>The evidence supporting a positive effect of using cortical perforations is very poor. Further studies with larger sample sizes are needed to determine whether decortication brings meaningful advantages.</p><p><strong>Clinical relevance: </strong>This study is focused on clinical studies and, using a rigorous study selection and a meta-analytic approach suggests that the apparent positive effect of bone decortication on the regeneration process still requires to be confirmed by more solid evidence.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"64"},"PeriodicalIF":3.1,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735581/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001307","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}