Clinical Oral Investigations最新文献

{"title":"Interactive associations of sagittal and vertical craniofacial skeletal patterns with upper cervical spine morphology and posture in growing patients.","authors":"Jiaming Zhang, Qingqin Xiao, Peiyin Sun","doi":"10.1007/s00784-026-07153-7","DOIUrl":"10.1007/s00784-026-07153-7","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the independent and interactive associations of sagittal and vertical craniofacial skeletal dimensions with upper cervical spine posture and morphology in growing patients.</p><p><strong>Materials and methods: </strong>Pretreatment lateral cephalograms of 726 children aged 7-14 years were retrospectively analyzed. Sagittal (ANB) and vertical (SN-MP) skeletal dimensions were treated as continuous variables. General linear models were constructed to evaluate their associations with cervical spine parameters while adjusting for sex and skeletal maturation. Significant ANB × SN-MP interaction effects were further explored using simple slope analyses.</p><p><strong>Results: </strong>The vertical skeletal dimension demonstrated the strongest and most consistent associations with cervical posture and upper cervical orientation parameters. In contrast, sagittal skeletal discrepancy showed more selective associations, primarily involving cervical inclination and selected intrinsic vertebral morphology variables. Significant ANB × SN-MP interaction effects were identified for CVT/NL, AIA, PDA, and ADA. Simple slope analyses demonstrated that the associations between ANB and selected cervical variables differed according to the underlying vertical skeletal pattern, although interaction effect sizes were generally modest (η² = 0.005-0.013).</p><p><strong>Conclusions: </strong>Distinct cervical domains demonstrated different patterns of association with sagittal and vertical craniofacial skeletal dimensions. While vertical skeletal characteristics were associated with broader cervical variations, sagittal skeletal discrepancy showed more region-specific relationships. In addition, significant interaction effects indicate that sagittal and vertical skeletal dimensions do not operate independently when examining craniofacial-cervical relationships.</p><p><strong>Clinical relevance: </strong>Assessment of cervical characteristics in growing orthodontic patients may benefit from simultaneous consideration of sagittal and vertical skeletal dimensions rather than evaluation of either dimension alone. These findings support a more integrated diagnostic perspective regarding craniofacial-cervical relationships during growth, rather than implying direct therapeutic consequences.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149073722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can vision-language models estimate patient age? evidence from panoramic radiographs.","authors":"Thaísa Pinheiro Silva, Fernanda Bulhões Fagundes, Maria Fernanda Andrade-Bortoletto, Christiano Oliveira-Santos, Deborah Queiroz Freitas, Matheus L Oliveira","doi":"10.1007/s00784-026-07183-1","DOIUrl":"10.1007/s00784-026-07183-1","url":null,"abstract":"<p><strong>Objective: </strong>To explore the performance and limitations of three vision-language models (VLMs) in estimating chronological age from panoramic radiographs.</p><p><strong>Materials and methods: </strong>A sample of 140 panoramic radiographs from individuals aged 7 to 20 years was uploaded to three VLMs: ChatGPT-4o, Microsoft Copilot Fast, and Microsoft Copilot Deep. Each VLM was independently prompted to estimate chronological age based on dental eruption patterns. The results were compared with the individuals' chronological ages. Statistical analysis included agreement within ± 1 year percentage calculation, and one-way analysis of variance to compare estimated and chronological ages (α = 0.05).</p><p><strong>Results: </strong>All three VLMs demonstrated low agreement in age estimation, with overall performance below 35%. Slightly better agreement was observed in individuals aged 9-10 years. The models showed greater deviations from chronological age at the extremes of the age range (7-8 and 17-20 years). No correct estimations were recorded for individuals aged 7, 17, 18, 19, and 20 years for ChatGPT-4o, 15 and 20 years for Microsoft Copilot Fast, and 20 years for Microsoft Copilot Deep.</p><p><strong>Conclusions: </strong>The evaluated VLMs showed limited agreement in estimating chronological age from panoramic radiographs. Therefore, their application in clinical and forensic contexts cannot currently be recommended.</p><p><strong>Clinical relevance: </strong>Understanding the potential applications and limitations of VLMs as an auxiliary tool in image interpretation is imperative to its use in clinical scenarios.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13616011/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058759","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The application of deep learning in intelligent assessment of horizontal bone loss in mandibular first molars.","authors":"Yuxuan Yang, Enwei Jin, Zirui Bian, Yifan Chen, Xiaoyu Chen, Yanmin Wu, Jingyi Tan","doi":"10.1007/s00784-026-07180-4","DOIUrl":"10.1007/s00784-026-07180-4","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to develop an assessment tool that utilizes deep learning (DL) techniques to automatically detect the extent of horizontal bone loss in mandibular first molars on cone-beam computed tomography (CBCT) images.</p><p><strong>Methods: </strong>A total of 505 CBCT images of patients with mandibular first molar horizontal bone loss were included in this study. Clinical experts annotated the horizontal bone loss areas, and a 3D-ResNets model was employed to classify the degree of horizontal bone loss. The diagnostic and classification performance of the model was then evaluated.</p><p><strong>Results: </strong>The 3D-ResNets model demonstrated accurate diagnosis and classification of healthy teeth, degree I/II horizontal bone loss teeth, and degree III horizontal bone loss teeth (Precision: 0.814 vs. 0.778 vs. 0.906; Recall: 0.921 vs. 0.737 vs. 0.829; F1-score: 0.864 vs. 0.757 vs. 0.866; Accuracy: 0.901 vs. 0.838 vs. 0.919). The model demonstrated reliable diagnostic performance, achieving an overall accuracy (OA) of 0.829, comparable to the dentist's OA of 0.820 (no significant difference).</p><p><strong>Conclusion: </strong>The 3D-ResNets model demonstrates high accuracy, sensitivity, and specificity in detecting the extent of horizontal bone loss in mandibular first molars on CBCT images, showing promising potential for clinical application.</p><p><strong>Clinical significance: </strong>The current study provides preliminary experimental support for the development of a clinical auxiliary diagnostic system to automatically detect the degree of horizontal bone loss in mandibular first molars.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of cold plasma activation on fluoride uptake and demineralization of enamel.","authors":"Alexandra Schmidt, Lukas Zingen, Sarah Barke, Bianca Rohland, Marcus Harms, Rinat Ortmann, Wolfgang Viöl, Annette Wiegand","doi":"10.1007/s00784-026-07167-1","DOIUrl":"10.1007/s00784-026-07167-1","url":null,"abstract":"<p><strong>Objectives: </strong>This in vitro study investigated the influence of cold plasma activation time prior to 1.25% fluoride gel application on fluoride uptake and demineralization of enamel.</p><p><strong>Materials and methods: </strong>Human enamel specimens (n = 200) were either treated with a dielectric-barrier plasma discharge at a constant distance (d = 1 mm), pulse repetition frequency (f₁ = 1 kHz), power (P_mean=36 mW) and voltage (U_pp=28 kV) for 0.5, 1, 2, or 30 s or received no plasma activation (each n = 40). Subsequently, half of the specimens from each group were coated with fluoride gel (1.25% NaF/AmF, t = 5 min). In each group, one subset of specimens (n = 10) was treated with KOH (1 M, 24 h) to quantify surface-deposited fluoride. Remaining specimens (n = 10) were demineralized (citric acid, pH 2.3, 60 s) to determine structurally bound fluoride as well as calcium and phosphate release. Statistical analysis was performed using linear mixed models and generalized linear mixed models with Tukey post-hoc tests (p < 0.05).</p><p><strong>Results: </strong>Fluoride gel significantly increased KOH-soluble and structurally bound fluoride and reduced calcium and phosphate release. Cold plasma activation had no significant effect on fluoride uptake or calcium and phosphate release. Plasma activation for 2 and 30 s resulted in a significant reduction of the calcium/phosphate ratio compared to the groups without plasma activation and without fluoride gel (p_adj.<0.001).</p><p><strong>Conclusions: </strong>Single cold plasma activation prior to fluoride gel application did not improve fluoride uptake or reduce demineralization of enamel.</p><p><strong>Clinical relevance: </strong>Under the investigated conditions, additional cold plasma activation provided no benefit beyond conventional topical fluoride treatment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of surface treatment protocols and thermocycling on the optical, surface, and mechanical properties of additively manufactured resin materials.","authors":"Esra Cengiz-Yanardag, Ayse Tugba Erturk-Avunduk, Ezgi Guven","doi":"10.1007/s00784-026-07170-6","DOIUrl":"10.1007/s00784-026-07170-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the effects of surface treatment protocols and thermocycling on the optical, surface, and mechanical properties of additively manufactured resins.</p><p><strong>Materials and methods: </strong>Five materials (saremco print CROWNTEC, VarseoSmile Crownplus, VarseoSmile TriniQ, VarseoSmile TriniQ for Formlabs, and Ceramic Crown) were assigned to six groups: control, silane, sandblasting (SB), SB+silane, hydrofluoric acid (HFA), and HFA+silane. After surface treatments and 5,000 thermocycles, color change (ΔE₀₀), translucency (ΔTP₀₀), gloss, surface roughness (Ra), and microhardness (VHN) were measured. Data were analyzed using robust ANOVA and aligned rank transform (ART) mixed ANOVA with Holm-adjusted multiple comparisons (α = 0.05).</p><p><strong>Results: </strong>Material type, surface treatment, and aging significantly affected all evaluated parameters (p < 0.001). Following surface treatment (T1), SB and SB + S groups exhibited significantly higher surface roughness and microhardness compared with control, silane, HFA, and HFA + S groups (p < 0.001). In terms of ΔE₀₀, SB and SB + S groups exceeded the clinical acceptability threshold (ΔE₀₀ > 1.8), whereas C, S, HFA, and HFA + S groups remained below the perceptibility threshold at T1. After thermocycling (T2), clinically unacceptable color changes were observed in most treatment groups, gloss values decreased significantly, and microhardness increased (p < 0.001). ΔTP₀₀ values were significantly influenced by material type (p < 0.001) but not consistently by surface treatment. Gloss values decreased significantly over time (p < 0.001), with the lowest values observed at T2. Among the materials, Ceramic Crown showed significantly higher microhardness and lower color change compared with the others (p < 0.05).</p><p><strong>Conclusions: </strong>Surface treatments and thermocycling significantly affect additively manufactured resins; mechanical pretreatments improve hardness but may compromise optical properties.</p><p><strong>Clinical relevance: </strong>Careful selection of surface treatment protocols is required to achieve a balance between mechanical performance and esthetic outcomes in additively manufactured restorations.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary inflammatory potential and oral-periodontal health in children: a cross-sectional study based on the children's dietary inflammatory index dietary inflammatory potential and oral-periodontal health in children.","authors":"Hilal Erdem Tuç, Ayça Kurt, Yagmur Demirel Ozbek","doi":"10.1007/s00784-026-07173-3","DOIUrl":"10.1007/s00784-026-07173-3","url":null,"abstract":"<p><strong>Objectives: </strong>Diet-related inflammatory processes have been implicated in the development of oral and periodontal diseases; however, data in pediatric populations remain limited. The Children's Dietary Inflammatory Index (C-DII) is a validated tool designed to assess the inflammatory potential of diet in children. This cross-sectional study aimed to evaluate the association between dietary inflammatory potential and oral-periodontal health parameters in children.</p><p><strong>Materials and methods: </strong>A total of 300 systemically healthy children aged 6-14 years were included. Sociodemographic characteristics and oral hygiene habits were recorded. Clinical examinations assessed DMFT/dmft, Plaque Index (PI), Gingival Index (GI), and Bleeding on Probing (BOP). Dietary intake was evaluated using three-day dietary records, and C-DII scores were calculated after energy standardization per 1000 kcal. Statistical analyses were performed using Jamovi (version 2.3.28), with significance set at p < 0.05.</p><p><strong>Results: </strong>C-DII scores showed a significant negative correlation with DMFT (p = 0.035) and a positive correlation with PI (p = 0.030). Quartile comparisons demonstrated significant differences in PI (p = 0.007), GI (p = 0.02), and BOP (p = 0.034) among children aged 6-10 years. In the 11-14-year group, GI (p = 0.002) and BOP (p = 0.01) values differed significantly across C-DII quartiles.</p><p><strong>Conclusions: </strong>Higher dietary inflammatory potential was associated with less favorable periodontal parameters in children. These findings suggest that proinflammatory dietary patterns may be linked to early periodontal changes.</p><p><strong>Clinical relevance: </strong>Assessment of dietary inflammatory potential may help identify children at increased periodontal risk and support preventive nutritional strategies in pediatric dental care.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of operator experience on the bond strength of etch-and-rinse, self-etch, and universal adhesive systems to dentin.","authors":"Camilo Pulido, Alessandro Dourado Loguercio, Camila Falconí-Páez, Cesar Augusto Galvão Arrais","doi":"10.1007/s00784-026-07163-5","DOIUrl":"10.1007/s00784-026-07163-5","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the influence of operator experience on the bonding performance of four adhesive strategies: three- and two-step etch-and-rinse (ER), and two- and one-step self-etch (SE) systems to dentin.</p><p><strong>Materials and methods: </strong>Ninety-six caries-free molars were divided according to the operator experience (3YG: third-year undergraduate students; 5YG: fifth-year undergraduate students; 1YR: first-year residents in Operative and Restorative Dentistry) and four adhesive systems. The occlusal third of each crown was removed to obtain a flat, mid-coronal dentin surface, which was standardized using 600-grit silicon carbide paper. Adhesives were applied following the manufacturer's recommendations, and a 4-mm-thick composite resin build-up was placed. Specimens were sectioned into resin-dentin beams (cross-sectional area ≈ 0.8mm²) for microtensile bond strength (µTBS) and nanoleakage (NL) evaluation. Data were analyzed using two-way ANOVA and Tukey's post-hoc test (α = 0.05).</p><p><strong>Results: </strong>The less experienced group (3YG) generally showed significantly lower µTBS and higher NL compared to more experienced operators (p < 0.05), with the exception of the 1-step SE strategy, where experience did not influence bond strength. Within the 3YG group, the 1-step SE approach yielded the highest µTBS values, whereas in the 5YG group, 1-step SE and 2-step ER showed the highest values; the 1YR group performed consistently across all adhesive systems. For NL, the 3YG group generally showed higher values than the more experienced groups, although 5YG and 1YR did not differ for the 1-step SE strategy. In the 3YG and 5YG groups, the 3-step ER strategy resulted in the highest NL values, whereas no significant differences among adhesive strategies were observed within the 1YR group.</p><p><strong>Conclusions: </strong>Two-step etch-and-rinse and one-step self-etch adhesives showed higher µTBS values and demonstrated lower sensitivity to operator experience compared with more technique-dependent multi-step systems.</p><p><strong>Clinical relevance: </strong>Simplified adhesive protocols may provide more predictable bonding outcomes in teaching environments and for clinicians with limited clinical experience.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluorescence compatibility of various resin composites on cervical restorations: An in-vitro evaluation.","authors":"Eminenur Uytun, Elif Alkan, Ezgi Tüter Bayraktar, Tuna Ünal Korkut, Bora Korkut, Dilek Tağtekin","doi":"10.1007/s00784-026-07152-8","DOIUrl":"10.1007/s00784-026-07152-8","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the fluorescence compatibility of five resin composite materials in cervical restorations using multiple assessment techniques.</p><p><strong>Materials and methods: </strong>Forty extracted A2 shade human molars were selected, and standardized Class V cavities were prepared on the buccal surfaces. The cavities were restored using five resin composite materials (n = 8). Fluorescence images were obtained using three assessment techniques based on fluorescence illumination: Tech-I (QrayPen C, 405 nm), Tech-II (Valo X with DSLR camera, 395-415 nm), and Tech-III (Ashur device with DSLR camera, 405 nm). Fluorescence differences (ΔE) were calculated using the CIEDE2000 formula. Statistical analyses included one-way ANOVA, Tukey post-hoc test, and Pearson correlation (p < 0.05).</p><p><strong>Results: </strong>Significant differences were observed among composite materials in all techniques (p < 0.001). Filtek Z250XT showed the lowest ΔE values (Tech-I: 3.83 ± 1.39, Tech-II: 3.60 ± 1.11, Tech-III: 3.41 ± 0.69), indicating the best fluorescence compatibility. Conversely, Estelite Asteria exhibited the highest ΔE values (Tech-I: 15.53 ± 3.94, Tech-II: 23.79 ± 2.72, Tech-III: 14.15 ± 2.46). Strong positive correlations were found among the techniques (Tech-I vs. Tech-II: r = 0.707; Tech-I vs. Tech-III: r = 0.774; Tech-II vs. Tech-III: r = 0.880; p < 0.001).</p><p><strong>Conclusion: </strong>The fluorescence compatibility of resin composite materials varies significantly depending on the material type. The Filtek Z250XT demonstrated the closest fluorescence compatibility to natural tooth structure. The assessment techniques showed strong agreement under standardized conditions.</p><p><strong>Clinical significance: </strong>Understanding the fluorescence behavior of composite materials may guide clinicians in selecting appropriate materials for improved esthetic outcomes and clinical performance.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A flexible piezoelectric sensor for non-contact monitoring of respiratory and heart rates: accuracy and clinical feasibility under simulated dental treatment conditions.","authors":"Fumi Kozu, Maho Suyama, Hiroyuki Kurakami, Chiho Kudo, Hiroshi Hanamoto","doi":"10.1007/s00784-026-07161-7","DOIUrl":"10.1007/s00784-026-07161-7","url":null,"abstract":"<p><strong>Objectives: </strong>Vital signs are not routinely monitored in dental practice, potentially delaying the recognition of medical emergencies. This study aimed to evaluate the accuracy of a piezoelectric sensor (Taido Sensor, Sumitomo Riko Co., Ltd., Nagoya, Japan) for measuring respiratory rate (RR) and heart rate (HR). Resilience against vibrations from cutting instruments was also assessed.</p><p><strong>Materials and methods: </strong>Fifteen healthy participants were monitored on a dental chair fitted with the sensor. Respiratory inductive plethysmography and electrocardiography served as reference methods. Three protocols were executed: (1) controlled breathing at 6-28 breaths/min; (2) HR recovery following a 3-min Master's two-step exercise test; and (3) clinical vibration simulated using an ultrasonic scaler, air turbine, and micromotors. RR and HR were derived from 30-s and 10-s waveform segments, respectively. Agreement was assessed using Lin's concordance correlation coefficient (CCC) and Bland-Altman analysis.</p><p><strong>Results: </strong>The CCC for RR during controlled breathing was 0.992, and that for HR post-exercise was 0.982. CCCs remained excellent for both RR (0.968-0.997) and HR (0.954-0.997) under various dental vibrations. Bland-Altman analysis revealed minimal fixed bias and clinically acceptable limits of agreement across all conditions.</p><p><strong>Conclusions: </strong>The Taido Sensor demonstrates high concordance with reference methods for vital signs measurements in routine dental practice, maintaining accuracy despite mechanical interference from dental instruments.</p><p><strong>Clinical relevance: </strong>Owing to its contactless design and ability to provide reliable data from short segments, the Taido Sensor could be a valuable tool for monitoring real-time vital signs during routine dental procedures, thereby enhancing patient safety.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13615905/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of injectable platelet-rich fibrin on orthodontically induced root resorption during tooth movement: a biomarker-based randomized controlled trial.","authors":"Rupa J Nimbai, Kapil M Sonar, Hema Yadav, Uday Hemant Barhate, Vilas D Samrit, Riyaz Ahmad Mir, Vikender S Yadav, Rajiv Balachandran, Prabhat Kumar Chaudhari, Ritu Duggal","doi":"10.1007/s00784-026-07157-3","DOIUrl":"10.1007/s00784-026-07157-3","url":null,"abstract":"<p><strong>Objectives: </strong>Orthodontically induced root resorption (OIRR) is a common adverse effect of orthodontic treatment, and early detection remains challenging. This randomized controlled trial aimed to evaluate the biological effect of injectable platelet-rich fibrin (i-PRF) on OIRR using dentin sialophosphoprotein (DSPP) levels in gingival crevicular fluid (GCF) as a biomarker during orthodontic tooth movement.</p><p><strong>Materials and methods: </strong>Thirty patients requiring bilateral maxillary first premolar extraction were randomly allocated to an i-PRF group (n = 15) or a control group (n = 15). In the intervention group, i-PRF was administered submucosally before incisor alignment. GCF samples were collected from maxillary central and lateral incisors at baseline (T0) and monthly for six months (T1-T6). DSPP concentrations were quantified using an enzyme-linked immunosorbent assay. Longitudinal changes in DSPP levels were analyzed using linear mixed-effects models to account for repeated measurements.</p><p><strong>Results: </strong>DSPP levels showed a significant time-dependent increase in both groups for central and lateral incisors (p < 0.001). However, the pattern of DSPP release differed significantly between groups. From the fourth month onward, DSPP levels were significantly lower in the i-PRF group compared with controls (p < 0.05). Lateral incisors consistently exhibited higher DSPP concentrations than central incisors.</p><p><strong>Conclusions: </strong>Administration of i-PRF before incisor alignment was associated with lower DSPP expression during orthodontic tooth movement, suggesting a possible biological effect of i-PRF on OIRR.</p><p><strong>Clinical relevance: </strong>The study provides preliminary biological evidence that i-PRF may influence processes associated with OIRR. If confirmed by future studies, i-PRF could serve as a minimally invasive adjunct to help reduce the risk of root resorption during orthodontic treatment.</p><p><strong>Trial registration no: </strong>CTRI/2023/08/056931 (Clinical Trial Registry of India).</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149058792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}