Clinical Oral Investigations最新文献

{"title":"Bleaching with biocatalysts and violet LED: a randomized clinical trial using a hybrid design with parallel-group and split-mouth approaches : Violet LED and biocatalysts in in-office whitening: a split-mouth trial.","authors":"Lara Maria Bueno Esteves, Carlos Alberto de Souza Costa, Luciano Tavares Angelo Cintra, Karen Milaré Seicento Aidar, Cristina de Mattos Pimenta Vidal, Alice de Oliveira Santos, André Luiz Fraga Briso","doi":"10.1007/s00784-025-06503-1","DOIUrl":"10.1007/s00784-025-06503-1","url":null,"abstract":"<p><strong>Objective: </strong>To compare conventional 35% hydrogen peroxide whitening for 45 min with test therapies lasting 15 min using a polymeric scaffold, peroxidase, and violet LED.</p><p><strong>Materials and methods: </strong>Sixty patients were randomized into three groups (n = 20): TC45 (35% HP for 45'), T15 (35% HP for 15'), and TT (polycaprolactone scaffold + 35% HP with peroxidase for 15'). One hemiarch was irradiated with violet LED (L) (8 cycles of 1 min, with 30-second intervals). ΔE₀₀ and ΔW_ID were evaluated using a portable spectrophotometer. Spontaneous sensitivity (questionnaire) and provoked sensitivity (thermal test) were assessed at T1, T2, T3, and after 7, 14, and 90 days (three-way repeated measures ANOVA). pH and hydrogen peroxide (HP) consumption were assessed during the first session (one-way ANOVA).</p><p><strong>Results: </strong>The TT group showed ΔE₀₀ efficacy similar to TC45 and superior to T15. With LED, the TTL group was equivalent to TCL45 and superior to TL15. Regarding ΔW_ID, TT was also comparable to TC45 and superior to T15, while TCL45 showed the best results with LED. LED irradiation significantly affected only the T15 groups. TC45 and TCL45 showed higher sensitivity, whereas TT and TTL exhibited lower pH drop and greater hydrogen peroxide degradation.</p><p><strong>Conclusion: </strong>Therapies using scaffold and peroxidase, with or without LED, were effective, safe, and less sensitive, representing promising alternatives to conventional whitening, even with a two-third reduction in application time.</p><p><strong>Clinical relevance: </strong>Whitening therapies using polymeric scaffold and peroxidase, with or without violet LED, are effective, safe, and cause less sensitivity, representing promising alternatives to conventional whitening.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"419"},"PeriodicalIF":3.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparison between venous blood sampling and capillary volumetric absorptive microsampling for antibiotics levels monitoring in individuals with and without periodontal disease.","authors":"Ioanna Lazaridi, Eva Choong, Thomas Mercier, Laurent A Decosterd, Catherine Giannopoulou, Alkisti Zekeridou","doi":"10.1007/s00784-025-06466-3","DOIUrl":"10.1007/s00784-025-06466-3","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;We aimed to compare the antibiotic concentrations obtained using the volumetric absorptive microsampling (VAMS) devices with those determined in plasma from conventional venous blood collected within the frame of a pharmacokinetic study of amoxicillin (AMO), metronidazole (MET), azithromycin (AZI), commonly used for periodontal treatment. The suitability and overall, acceptability of the VAMS approach was also ascertained by both participants of the pilot study and dentist practitioners.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;Twelve volunteers (6 subjects without periodontal problems (PH), and 6 individuals affected with periodontitis (PP)) were administered 500 mg each of amoxicillin, metronidazole, and azithromycin. Paired venous blood (VB) and capillary VAMS samples were collected at 2-, 6-,10-, 24-, 48- and 96-hours post-antibiotics administration. Antibiotic concentrations were determined using multiplex liquid chromatography coupled tandem mass spectrometry (LC-MS/MS). Statistical analyses included Mann-Whitney U tests and t-tests.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Significant differences in antibiotic concentrations were observed between VAMS and venous blood (VB) collection methods, across different time points for the three antibiotics (p &lt; 0.05). AMO concentrations in VB were 3.5-fold higher (p &lt; 0.01) than in VAMS at early time points (2, 6, 10 h (h)). MET levels in VB were 1.5-fold higher than in VAMS at 2 h and 6 h, (p &lt; 0.01), but this difference disappeared after 10 h. Alternately, while AZI levels were similar in VB and VAMs 2 h after administration, AZI concentrations in VB and VAMS declined non parallelly, with VB levels decreasing to about 60 to 25% of those measured in VAMS over the observed 96 h interval. Antibiotic exposures were not different in the PH and PP groups. Differences in antibiotics concentrations determined in VB and VAMS samples are a direct consequence of (i) the matrices used for analyses (plasma in VB, vs. whole blood with VAMS), (ii) the subjects' hematocrit, and (iii) the distinct cell distribution pattern of antibiotics with AMO characterized by a weak penetration in red blood cells (RBC) while AZI tends to progressively concentrate into RBC. MET was present at higher concentrations in plasma until 6 h which thereafter tended to re-equilibrate equally in plasma and RBC.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Though VAMS yielded significantly different results compared to plasma, it effectively reflects the concentration evolution of the antibiotics and could be an alternative in pharmacokinetic studies and therapeutic monitoring.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical relevance: &lt;/strong&gt;VAMS holds promise in advancing therapeutic drug monitoring in periodontal research and clinical practice. Being less invasive than venous puncture it is well accepted by subjects and facilitate blood monitoring in clinical trials and non-hospital settings. Its minimal invasiveness and simplified logistic","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"420"},"PeriodicalIF":3.1,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12374872/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A critique to the article \"Pina PSS, Mendes AT, Correa L, Coracin FL, de Sousa SCOM. The role of exfoliative cytology in diagnosis of oral lesions. Clin Oral Investig. 2024 Dec 6;29(1):2. doi: 10.1007/s00784-024-06080-9. PMID: 39641812.\"","authors":"Pelin Güneri, Gaye Bolukbasi","doi":"10.1007/s00784-025-06502-2","DOIUrl":"10.1007/s00784-025-06502-2","url":null,"abstract":"<p><strong>Objective: </strong>This letter critiques the study by Pina PSS et al., titled \"The role of exfoliative cytology in the diagnosis of oral lesions,\" published in Clinical Oral Investigations (doi: https://doi.org/10.1007/s00784-024-06080-9 ). The study aimed to evaluate the utility of oral exfoliative cytology and highlighted its limited effectiveness in diagnosing oral diseases.</p><p><strong>Materials and methods: </strong>Among 1000 cases, the authors misclassified prosthetic stomatitis (denture stomatitis) as a distinct clinical entity separate from candidiasis, despite its fungal etiology. This classification approach could compromise the accuracy of exfoliative cytology.</p><p><strong>Results: </strong>In 817 cases (81.7%), clinicians provisionally diagnosed fungal lesions, with significant disagreement between provisional and cytological diagnoses. However, the absence of histological examination as a gold standard precludes evaluating the accuracy of both \"clinical examination alone\" and \"exfoliative cytology.\" Thus, the disagreement lacks actionable clinical implications.</p><p><strong>Conclusion: </strong>The authors advocated to restrict the utilization of exfoliative oral cytology particularly for diagnosing fungal disease, and occasionally when oral cancer is suspected. On the contrary, we consider that exfoliative oral cytology adds little value to a thorough patient anamnesis and clinical examination in fungal disease diagnosis, and may be proposed in rare cases. Its primary utility lies in assessing the malignant potential of oral mucosal lesions rather than fungal or viral infections.</p><p><strong>Clinical relevance: </strong>The findings reveal the need to enhance clinicians' skills in provisional diagnosis rather than focusing on the limitations of exfoliative cytology. Concluding that oral cytology has limited applications in oral disease diagnosis, as the study suggests, appears unwarranted.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"417"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Gingipain inhibitors as an innovative therapy for periodontal and associated-systemic diseases: a systematic review.","authors":"Maria Elisa Pedrosa, Victor Martin, Maria Helena Fernandes, Pedro Sousa Gomes","doi":"10.1007/s00784-025-06472-5","DOIUrl":"10.1007/s00784-025-06472-5","url":null,"abstract":"<p><p>Periodontal diseases (PDs) are prevalent chronic inflammatory conditions linked to the progression of systemic disorders. Gingipains, cysteine proteases produced by Porphyromonas gingivalis, are key virulence factors involved in PD pathogenesis and host-tissue degradation. Inhibiting these enzymes has emerged as a promising therapeutic approach.</p><p><strong>Objective: </strong>This systematic review evaluates the potential of gingipain inhibitors in the management of PDs and related systemic conditions.</p><p><strong>Methods: </strong>A systematic search was conducted across PubMed, Scopus, and Web of Science using the PICOS framework. Studies were evaluated based on their objectives, experimental models, inhibitor types, and outcomes.</p><p><strong>Results: </strong>Seven preclinical studies met the inclusion criteria. No clinical studies were identified. In preclinical models, gingipain inhibitors demonstrated consistent therapeutic benefits, including reduced inflammation, bacterial load, and tissue destruction in PDs, as well as improved outcomes in cardiovascular and AD models. Dual inhibitors targeting both Rgp and Kgp enzymes were more effective than single-target agents.</p><p><strong>Conclusion: </strong>Gingipain inhibitors hold promise as therapeutic agents for PDs and associated systemic diseases. However, the absence of clinical studies highlights the need for further development and clinical evaluation to support their translational potential.</p><p><strong>Clinical relevance: </strong>By targeting specific and key components of host-bacterium interactions, gingipain inhibitors represent a promising adjunctive therapy for modulating periopathogen virulence factors, thereby mitigating the progression of PDs and associated systemic diseases.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"418"},"PeriodicalIF":3.1,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12370816/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144944968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of tooth loss with circadian syndrome in US adults: the mediated role of systemic inflammation.","authors":"Yundong Liu, Yuhao Liu, Tao Yin, Mi He, Changyun Fang, Shifang Peng","doi":"10.1007/s00784-025-06480-5","DOIUrl":"10.1007/s00784-025-06480-5","url":null,"abstract":"<p><strong>Background: </strong>The current study was to investigate the associations of missing teeth or lost functional tooth units (FTUs) with circadian syndrome and the mediated effects of systemic inflammation as indicated by serum C-reactive protein (CRP).</p><p><strong>Methods: </strong>Dentition examination, high-sensitivity serum CRP, and circadian syndrome data of 11,490 participants aged 18-80 years from US National Health and Nutrition Examination Survey 2015-2020 were analyzed. Generalized linear model and mediation effect model were used.</p><p><strong>Results: </strong>After adjusting confounders, the numbers of missing teeth or lost FTUs and Ln-transformed CRP were positively associated with higher circadian syndrome prevalence (odds ratio and 95% confidence interval: missing teeth: 1.01(1.00, 1.01), P = 0.043; lost FTUs: 1.02(1.01, 1.03), P = 0.001; CRP: 1.23(1.20, 1.26), P < 0.001). Furthermore, positive associations between the numbers of missing teeth or lost FTUs and Ln-transformed CRP but inverse association between implant prosthesis and Ln-transformed CRP were observed after adjustment (β ± standard error: missing teeth: 0.012 ± 0.002; lost FTUs: 0.024 ± 0.005; implant prosthesis: -0.136 ± 0.053). Moreover, significant mediation effects of serum CRP were observed in the associations of missing teeth or lost FTUs with circadian syndrome. The mediated proportions (%) for missing teeth or lost FTUs were 32% and 20% respectively.</p><p><strong>Conclusions: </strong>Missing teeth or lost FTUs were positively associated with serum CRP and circadian syndrome in US adults. Systemic inflammation partly mediated the association of missing teeth or lost FTUs with circadian syndrome.</p><p><strong>Clinical relevance: </strong>Maintaining more natural teeth may be associated with lower circadian syndrome prevalence.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"416"},"PeriodicalIF":3.1,"publicationDate":"2025-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Positional and dimensional temporomandibular joint osseous changes in patients treated with the forsus fatigue resistant device: a non-randomized clinical trial.","authors":"Ramy Abdul-Rahman Ishaq, Maged S Alhammadi, Mona M Salah Fayed, Sherif A Elkordy, Najah Alhashimi, Abeer A Almashraqi","doi":"10.1007/s00784-025-06474-3","DOIUrl":"10.1007/s00784-025-06474-3","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the osseous positional and dimensional changes in the temporomandibular joint (TMJ) of patients with skeletal Class II malocclusion treated with the Forsus Fatigue Resistant Device (FFRD).</p><p><strong>Materials and methods: </strong>This non-randomized clinical trial included 40 female subjects, aged 11 to 15, with skeletal Class II malocclusion. Participants were divided into a treatment and a control group. After alignment and leveling with fixed orthodontic appliances using 0.019 × 0.025-inch stainless-steel archwires, the FFRD was fitted. The overjet was corrected to achieve an edge-to-edge incisor relationship. Cone Beam Computed Tomography (CBCT) images were taken before (T1) and after (T2) the fixed functional phase. The TMJs were assessed for positional and dimensional osseous changes in the mandibular condyles, glenoid fossae, and joint spaces. Intra- and inter-group comparisons were conducted using paired t-tests and independent t-tests, respectively.</p><p><strong>Results: </strong>The initial measurements of age, cervical stage, anteroposterior and vertical skeletal alignment, and TMJ parameters were similar between the study and control groups. Three participants from the study group were lost to follow-up, resulting in 17 participants completing the trial. In the treatment group, condylar width decreased significantly by 0.52 ± 0.92 mm, in contrast to an increase of 0.17 ± 0.35 mm in the control group (P = 0.010). Moreover, the anterior wall inclination in the treatment group was reduced by 3.13 ± 10.77 degrees, compared to an increase of 2.95 ± 4.1 degrees in the control group (P = 0.003). All other measurements displayed no significant differences between the two groups.</p><p><strong>Conclusion: </strong>In the short term, the FFRD redirected the growth of the articular eminence anteriorly, contrasting with the normal growth pattern of untreated individuals. However, no additional positional or dimensional changes in the TMJ were observed.</p><p><strong>Clinical relevance: </strong>By aligning the jaw and correcting overjet, clinicians can potentially enhance occlusal relationships and contribute to better jaw function. However, it is important to investigate whether this process is associated with any changes in the bony structures of the TMJ. This study underscores the efficacy of the FFRD in reshaping the osseous components of the TMJ, which may lead to improved functional outcomes for patients with skeletal Class II malocclusion.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"414"},"PeriodicalIF":3.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358331/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture resistance of molars receiving nanoceramic-resin CAD/CAM onlays after cervical marginal elevation with different injectable restorative materials: effect of six-month water storage.","authors":"Basema Nader Roshdy, Radwa Ibrahim Eltoukhy, Ashraf Ibrahim Ali, Salah Hasab Mahmoud","doi":"10.1007/s00784-025-06509-9","DOIUrl":"10.1007/s00784-025-06509-9","url":null,"abstract":"<p><strong>Objective: </strong>To assess the influence of six-month water storage on the fracture resistance of molars receiving mesio-occluso-distal (MOD) nanoceramic CAD/CAM onlay restorations after cervical marginal elevation (CME) with different injectable restorative materials.</p><p><strong>Materials and methods: </strong>Two hundred ten sound mandibular molars received standardized MOD onlay preparations with cervical margins extending 2 mm apical to the cementoenamel junction (CEJ). Molars were randomly assigned into five groups (n = 42) according to the restorative materials used for CME: No-CME Group, control; CME-HVGI Group, highly viscous glass ionomer; CME-ICR Group, injectable composite resin; CME-RMGI Group, resin-modified glass ionomer; CME-BAIR Group, bioactive ionic resin. Immediate dentin sealing was performed on each molar before receiving nanoceramic-resin CAD/CAM onlay restoration. Each group was subdivided into two subgroups (n = 21) based on whether they underwent six months of water storage. All specimens were subjected to clinical simulation via thermo-mechanical loading, fracture resistance testing, and failure mode analysis.</p><p><strong>Results: </strong>No statistically significant difference in fracture resistance was observed when comparing the tested CME groups to the control group after six months of water storage. Regarding failure mode, irreparable failure was significantly dominant, with no significant difference among all groups.</p><p><strong>Conclusions: </strong>Six-month water storage had no adverse effect on the fracture resistance of teeth receiving nanoceramic onlay restorations, regardless of the type of cervical margin elevating material used.</p><p><strong>Clinical relevance: </strong>The smoothly handled injectable restorative materials used for CME of molars with nanoceramic-resin CAD/CAM onlay restorations could endure humid conditions, exhibiting acceptable performance under compressive loading.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"415"},"PeriodicalIF":3.1,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of periodontal disease prediction system on oral hygiene motivation in patients with periodontitis: a prospective randomized controlled clinical study.","authors":"Sadiye Gunpinar, Ümran Gündoğdu Ezer, Seda Gönülay, A Alper Tasmektepligil, Erkan Gunpinar","doi":"10.1007/s00784-025-06476-1","DOIUrl":"10.1007/s00784-025-06476-1","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study is to enhance and maintain individual patients' oral hygiene motivation using a computer-based visualization program entitled as Periodontal Disease Prediction (PDP).</p><p><strong>Materials and methods: </strong>Patients were randomly assigned to three groups: (a) conventional method group (CM, n = 40), (b) Three-dimensional animation (3DA, n = 40), and (c) PDP interaction (n = 40). A total of 120 patients (60 females, 60 males; aged 30-60 years) diagnosed with Stage III Grade B periodontitis and poor oral hygiene (OHI-S > 3) were included. Baseline data of all patients including probing depth (PD), papillary bleeding index (PBI), bleeding on probing (BOP), Rustogi modified Navy Plaque Index (RMNPI) were recorded, and all patients received the necessary scaling and root planing. All groups were examined periodontally at 3, 6, and 12 months after initial periodontal treatment.</p><p><strong>Results: </strong>At all evaluated time periods, PDP group demonstrated a significantly greater reduction in PBI and RMNPI, particularly associated with interproximal surface cleaning, compared to the other groups (p < 0.05). In contrast, the 3DA and CM groups showed no significant differences between them (p > 0.05). Furthermore, PDP group showed significantly greater reduction in BOP compared to the other groups, but this was only observed at the 3-month reevaluation. There were no significant differences among the groups regarding PD and pocket closure (PD ≥ 4 mm %) (p > 0.05).</p><p><strong>Conclusion: </strong>Informing patients about their probable periodontal breakdown using the PDP system, which simulates their individual condition, can enhance their oral hygiene motivation, particularly in maintaining effective interface cleaning. This approach may also help reduce the risk of periodontal disease recurrence.</p><p><strong>Clinical relevance: </strong>Background: Periodontal disease is prevalent and often recurs due to inadequate oral hygiene. This study assesses the effectiveness of a computer-based Periodontal Disease Prediction (PDP) system in motivating patients to improve their oral hygiene. Added Value of this Study: The PDP system provides personalized 3D visualizations of potential gingival recession, boosting patient engagement and encouraging more effective interproximal cleaning. By visualizing future oral health outcomes, it significantly motivates patients to adopt better hygiene practices.</p><p><strong>Clinical implications: </strong>PDP can be integrated into routine dental practice to enhance patient adherence to oral hygiene, thereby reducing the risk of periodontal disease recurrence. This method offers a more engaging, individualized approach to oral health education, leading to improved long-term periodontal outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"412"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144844779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro effect of fluoride-free mouthwashes on Streptococcus mutans biofilm.","authors":"Astrid C Valdivia-Tapia, Frank Lippert, Peter F Castelluccio, Jaime A Cury, Antonio P Ricomini-Filho, Richard L Gregory","doi":"10.1007/s00784-025-06462-7","DOIUrl":"10.1007/s00784-025-06462-7","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy of commercially available, fluoride-free mouthwashes sold in Indianapolis, IN, on Streptococcus mutans biofilm.</p><p><strong>Materials and methods: </strong>Eighty-one different mouthwashes were purchased. A 16-h culture of S. mutans UA159 was treated with the mouthwashes in three dilutions (1:3, 1:6, and 1:12), prepared in Tryptic Soy broth supplemented with 1% sucrose. The minimum inhibitory concentrations (MIC), planktonic, and biofilm growth were evaluated using a spectrophotometer. In addition, the growth for minimum bactericidal concentration (MBC) was evaluated using five μL of the dilution and incubated on blood agar. For the analysis of the results, the mouthwashes were separated into six groups according to their active ingredients (cetylpyridinium chloride/CPC, n = 25; essential oils/EO n = 10; whitening/W (hydrogen peroxide/ sodium hexametaphosphate), n = 12; Natural-Derived Actives / NDA, n = 15; zinc chloride/ZC, n = 3; others/O, n = 16). ANOVA followed by the Tukey test was performed (p < 0.05).</p><p><strong>Results: </strong>Regarding MIC, planktonic, and biofilm growth of S. mutans, there was a significant decrease for the W and CPC groups (p < 0.001). The EO and W groups had more inhibition on S. mutans biofilm compared to the CPC group (p < 0.05). For ZC, NDA, and O groups, there were different effects within the same group, presenting a large variability. About MBC, W and CPC groups presented the higher inhibition (W > CPC > EO > NDA/ZC/O).</p><p><strong>Conclusion: </strong>The mouthwashes demonstrated significant effect on S. mutans biofilm, especially in the 1:3 dilution. W and CPC groups had a more significant effect on S. mutans biofilm.</p><p><strong>Clinical relevance: </strong>S. mutans is an important bacterium in dental caries and periodontal diseases. Our study showed that non-fluoridated mouthwashes affect the initial stages of biofilm formation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"413"},"PeriodicalIF":3.1,"publicationDate":"2025-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12354505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144854792","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of imaging protocol and tube current adjustment on the radiation dose in CBCT imaging of mandibular incisors.","authors":"Jardel Francisco Mazzi-Chaves, Iago Ramirez, Grasielle Camargo Gonçalves Alcebíades, Julia Godoi Lopes, Amanda Pelegrin Candemil, Rocharles Cavalcante Fontenele, Fabiane Carneiro Lopes-Olhê, Cassiana Viccari, Patricia Nicolucci, Danieli Moura Brasil, Christiano Oliveira-Santos, Manoel Damião Sousa-Neto, Hugo Gaêta-Araujo","doi":"10.1007/s00784-025-06499-8","DOIUrl":"10.1007/s00784-025-06499-8","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the impact of imaging protocols involving tube current (mA) adjustment on the equivalent and effective radiation dose for cone-beam computed tomography (CBCT) of mandibular incisors using the corresponding periapical radiography as clinical reference.</p><p><strong>Methods: </strong>An anthropomorphic head and neck phantom equipped with 24 thermoluminescent dosimeters (TLDs) was used to evaluate radiation exposure across seven imaging protocols: high-dose CBCT (4.0, 7.1, and 10 mA), low-dose CBCT (3.2, 4.5, and 6.3 mA), and standard periapical radiography (7 mA). Equivalent and effective radiation doses were calculated according to tissue-weighting factors outlined in ICRP Publication 103.</p><p><strong>Results: </strong>Effective dose increased proportionally with tube current, ranging from 53 to 175 µSv in high-dose protocols and from 8.6 to 18 µSv in low-dose protocols. Periapical radiography yielded the lowest effective dose (1.4 µSv). The highest equivalent doses were recorded for the salivary glands and oral mucosa across all protocols.</p><p><strong>Conclusions: </strong>CBCT protocols with reduced tube current significantly decrease radiation exposure. The lowest setting tested (3.2 mA) resulted in an effective dose comparable to six periapical radiographs. These findings support the implementation of low-dose CBCT for complex endodontic diagnostics, particularly during initial evaluations, in alignment with the ALADAIP principle.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"411"},"PeriodicalIF":3.1,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144834354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}