Clinical Oral Investigations最新文献

{"title":"Discriminating bacterial types in oral and maxillofacial space infections (OMSIs) via smelling diagnosis.","authors":"Rui Ren, Xue Jiang, Shanluo Zhou, Haiqiang Li, Qiang Niu, Danyao Qu, Ruizhi Ning, Zerou Zhang, Liang Kong, Weiwei Wu, Yunpeng Li","doi":"10.1007/s00784-025-06243-2","DOIUrl":"10.1007/s00784-025-06243-2","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the feasibility of using gas chromatography-mass spectrometry (GC-MS) in the diagnosis of bacterial types of oral and maxillofacial space infections (OMSIs).</p><p><strong>Methods: </strong>Staphylococcus aureus was cultured to produce a full spectrum of volatile organic compounds (VOCs). These VOCs were collected and identified using VOC collectors and GC-MS. A bacteria Probability-based VOC Algorithm (BPVA) was developed to assess the likelihood of infection in vivo utilizing a rat model. VOCs from 19 clinical OMSIs abscess samples were analyzed to calculate the probability of SA infection, with results validated against traditional culture results.</p><p><strong>Results: </strong>Using fold change (FC), p-values (P), and variable importance in projection (VIP) values, we identified 318 characteristic target compounds associated with Staphylococcus aureus. After fitting these compounds to the rat infection model, 189 compounds were selected, establishing a BPVA threshold of ≥ 50, with a 95% probability of consistency. Four patients exhibited an SA infection probability exceeding 70%, whereas the other patients fell below this threshold. Clinical results confirmed SA infections in these four patients, with detection times reduced to approximately 24 h, significantly shorter than the typical 3-5 days.</p><p><strong>Conclusions: </strong>The combination of GC‒MS and BPVA significantly accelerated the diagnosis of bacterial types in OMSIs, demonstrating strong agreement with traditional culture results, highlighting a new method to accurately and rapidly diagnose maxillofacial infections.</p><p><strong>Clinical relevance: </strong>Rapid identification of bacterial types is essential for treating OMSIs. However, current bacterial culture methods face challenges, such as limited accuracy and time-consuming processes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"157"},"PeriodicalIF":3.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-vitro validation of a new method to assess the clinical accuracy of complete arch impressions.","authors":"Moritz Waldecker, Schessler Katherina, Bömicke Wolfgang, Rammelsberg Peter, Rues Stefan","doi":"10.1007/s00784-025-06236-1","DOIUrl":"10.1007/s00784-025-06236-1","url":null,"abstract":"<p><strong>Objectives: </strong>To develop and validate a new method to acquire reference distances.</p><p><strong>Materials and methods: </strong>A method to accurately register the intraoral position of precision balls was developed to generate reference values for the in-vivo assessment of impression accuracy and tested in vitro. Therefore, metal occlusal veneers with a special abutment carrying precision balls were provisionally attached to specific positions on the patient's dental arch (anatomical model with PMMA covered metal teeth). To register the precision ball positions, form-congruent counterparts were jointed to the abutments, adhesively fixed to a transfer aid, removed and digitized with a laboratory scanner. First, the distance determination using a transfer aid and a laboratory scanner was validated. Second, the process was tested for an anatomic situation.</p><p><strong>Results: </strong>When measuring distances using a transfer aid and a laboratory scanner, distances could be detected with an accuracy of less than 5 μm. Using the new test setup on the anatomical model, the intraoral scanners more accurately reproduced scan volumes up to one quadrant, with deviations between the actual scan data sets/plaster models and the reference data set of < 52 μm for Primescan, < 82 μm for Omnicam, and < 125 μm for conventional impression. Longer distances tended to be more accurately represented by the conventional impression (Primescan < 304 μm; Omnicam < 328 μm; conventional impression < 164 μm).</p><p><strong>Conclusions: </strong>The developed method seems suitable for determining the clinical accuracy of conventional and digital complete arch impressions.</p><p><strong>Clinical relevance: </strong>For determining the clinical accuracy of conventional or digital impressions, reference values are crucial.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"156"},"PeriodicalIF":3.1,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11861410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143491202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the overall fit of three-unit posterior fixed dental prostheses fabricated with laser sintering and conventional casting methods.","authors":"Gürel Pekkan, Kubra Degirmenci, Süleyman Hakan Tuna, Canan Hekimoğlu, Serkan Saridag","doi":"10.1007/s00784-025-06221-8","DOIUrl":"10.1007/s00784-025-06221-8","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to investigate the marginal, internal, and occlusal discrepancies of three-unit posterior cobalt-chromium (Co-Cr) fixed dental prostheses (FDPs) produced using five different fabrication techniques.</p><p><strong>Materials and methods: </strong>Segmental maxillary models were prepared from polyamide material using a laser sintering method. The maxillary first premolar and first molar teeth were prepared to receive posterior FDPs. Direct metal laser sintering (DMLS) and selective laser melting (SLM) were used as two metal laser Co-Cr framework production systems. FDP specimen patterns were prepared by manual wax carving (Cast), 3D-printed polymer (3DP), and CAD/CAM wax and cast using the lost-wax technique as conventional methods. In total, 100 Co-Cr metal framework specimens were prepared for posterior FDPs (n = 20). The silicone replica technique was used to measure marginal, internal, and occlusal discrepancies of all frameworks. A stereomicroscope was employed to detect discrepancies at 100× magnification. The data were analyzed using two-way ANOVA (α = 0.05) and post hoc Bonferroni adjustment (α = 0.005) for pairwise comparisons.</p><p><strong>Results: </strong>There were no significant differences between the occlusal discrepancy values of premolar abutments of FDPs when compared with different fabrication methods (P > 0.05). The highest marginal discrepancy value was detected as 116.22 μm for molar abutment when the Cast method was used (P < 0.05). The highest occlusal discrepancy values were detected as 135.60 μm and 141.49 μm for molar abutments of posterior FDPs when the 3DP and Cast methods were used. The lowest marginal discrepancy value was detected as 38.94 μm for molar abutments when the DMLS method was used (P < 0.05).</p><p><strong>Conclusions: </strong>The DMLS method was more successful than other fabrication methods when fit values of abutment teeth for posterior frameworks were compared.</p><p><strong>Clinical relevance: </strong>The morphology of the abutment teeth and the fabrication techniques of FDPs migth affect the discrepancy values of FDPs planned. It was seen that the discrepancy values were lowest with the DMLS and SLM methods. Considering the results of this in-vitro study, DMLS and SLM techniques may be more appropriate option than the 3DP method, which starts with digital design and ends conventionally casting technique for posterior three-unit FDPs.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"153"},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11847754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Polishing of 4Y- and 5Y- zirconia: effects on roughness, color and gloss.","authors":"Laura Koch, Sebastian Hahnel, Angelika Rauch, Martin Rosentritt","doi":"10.1007/s00784-025-06244-1","DOIUrl":"10.1007/s00784-025-06244-1","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the effects of polishing systems on the roughness, gloss and color of two zirconia materials as a function of the rotational speed and number of polishing movements.</p><p><strong>Materials and methods: </strong>Specimens (n = 8/group) from 4Y-TZP and 5Y-TZP were milled, diamond grinded and polished. The intraoral polishing varied in the number of polishing steps, the grain size and the matrix. Different number of polishing movements and rotation speed were used. Roughness (ISO25178-2:2021), gloss (ISO2813:2014) and color stability (ISO/CIE 11664-4:2019) were determined.</p><p><strong>Statistics: </strong>Shapiro-Wilk, one-way analysis, Bonferroni, Pearson, variance analysis/intermediate sub-effects (α = 0.05).</p><p><strong>Results: </strong>Roughness Sa varied between 2.45 ± 0.93 µm and 6.47 ± 0.26 µm (4Y-TZP) and 2.31 ± 0.19 µm and 6.54 ± 0.22 µm (5Y-TZP). Maximum roughness Sz ranged from 32.92 ± 12.59 µm to 99.32 ± 19.87 µm (4Y-TZP) and 31.45 ± 3.02 µm to 90.75 ± 12.59 µm (5Y-TZP). Different gloss from 28.9 ± 4. 23 to 102.39 ± 18.63 GU (4Y-TZP) and 33.19 ± 3.68 to 101.28 ± 10.00 GU (5Y-TZP) was found. ΔE results ranged from 0.39 ± 0.34 to 6.30 ± 1.22 (4Y-TZP) and 0.87 ± 0.71 to 7.50 ± 1.67 (5Y-TZP). Significant (p ≥ 0.095) intermediate sub-effects were found.</p><p><strong>Conclusions: </strong>Polishing led to a reduction in roughness, an increase in gloss and a significant change in color. Polishing had a stronger effect on 5Y-TZP.</p><p><strong>Clinical relevance: </strong>The correct use of the polisher type (stages, binder) and its specific application (rotational speed, movements) can improve roughness, gloss and color variations.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"154"},"PeriodicalIF":3.1,"publicationDate":"2025-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11850485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CBCT image based radiomic analysis for condylar resorption after orthognathic surgery.","authors":"Ruo-Han Ma, Ji-Ling Feng, Jia-Yang Chen, Yu-Xuan Yang, Ju-Peng Li, Gang Li","doi":"10.1007/s00784-025-06227-2","DOIUrl":"10.1007/s00784-025-06227-2","url":null,"abstract":"<p><strong>Objectives: </strong>To select and discover features which are highly correlated with condylar resorption (CR) after orthognathic surgery (OS) by a new method.</p><p><strong>Materials and methods: </strong>The cone beam computed tomography (CBCT) images were collected from orthognathic patients taken at T1(baseline time point) and T2(within 3-36 months postoperatively). The subjects were divided into the CR group and the control group by using a 2-level scale after registering T1 and T2 images. The condyles were segmented by MVEL-Net network model and were analyzed by Pyradiomics. The D-value equaled to the absolute difference-value (D-value) between the feature values of T1 and T2. The correlation between features with statistically significant differences in T1 and D-values would be analyzed to find the specific features related to CR after OS.</p><p><strong>Results: </strong>A total of 145 subjects were included (27 males and 118 females), which had 44 subjects in the CR group, 101 subjects in the control group. For all samples, a total of 82 features were extracted (F₁), which were with statistical differences at T1 time point between CR and control groups. By using the D-value, the number of features was reduced to 32 features (F_d). Among F_d, only 3 were not included in F₁.</p><p><strong>Conclusions: </strong>The D-value was proposed for selecting specific features of CR after OS and it can be observed that the D-value serves the purpose of feature specification compared to T1 values. By using the D-values, several features were found to change significantly during the process of CR after OS.</p><p><strong>Clinical relevance: </strong>The features selected by D-value can be used for the establishment of a prediction model for CR after OS.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"152"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143476343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A retrospective, cross-sectional analysis of the dental status and needs of patients taking vascular endothelial growth factor (VEGF) antagonists.","authors":"Alexander Raucci, Katherine France","doi":"10.1007/s00784-025-06230-7","DOIUrl":"10.1007/s00784-025-06230-7","url":null,"abstract":"<p><strong>Objectives: </strong>There is growing literature related to the dental effects of biologic agents. However, little research has evaluated the dental needs of these patients and limited data is available on patients taking vascular endothelial growth factor (VEGF) antagonists.</p><p><strong>Materials and methods: </strong>This retrospective cross-sectional study analyzed patients taking VEGF antagonists and their respective dental treatments from 2017 to 2023. Patient demographics, decayed, missing, and filled tooth (DMFT) status, and treatment details were recorded and evaluated descriptively. DMFT from this population was compared to patients taking other biologic agents using t-tests.</p><p><strong>Results: </strong>Twenty-three patients taking VEGF antagonists received dental treatment. Periodontal treatments were the most common (n = 18, 78%), followed by restorative treatments (n = 17, 74%). DMFT data for patients taking VEGF antagonists were not significantly different than values for patients taking other biologic agents, except for patients taking TNF-α Inhibitors, who had significantly fewer missing teeth than patients taking VEGF antagonists (3.88 vs. 8.10, p = 0.01).</p><p><strong>Conclusions: </strong>The necessity of dental treatment in patients taking VEGF Antagonists is still unknown. Periodontal and restorative treatments were the most common modalities with no complications observed from treatment. While preventive periodontal treatment is routinely recommended, high usage of targeted periodontal and restorative treatments is seen in this population.</p><p><strong>Clinical relevance: </strong>Minimal evidence exists to date on the delivery of and need for routine dental treatment among patients taking VEGF antagonists. This paper presents a first estimate of dental needs in this population.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"151"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unique clinical features and prognostic risk factors of oral squamous cell carcinoma in patients under 30 years old.","authors":"Hao-Yang Cheng, Yu-Xuan Wu, Zi-Li Yu","doi":"10.1007/s00784-025-06213-8","DOIUrl":"10.1007/s00784-025-06213-8","url":null,"abstract":"<p><strong>Background: </strong>Individuals under 30 years old with oral squamous cell carcinoma (OSCC) are a relatively rare subgroup but require attention. However, literature on the clinicopathological characteristics of OSCC patients under 30 is currently lacking.</p><p><strong>Methods: </strong>A total of 66 OSCC patients under 30 were included in this study. We collected data on demographic characteristics, chief complaint, risk factors, pathological features, imaging, blood test, staging, neoadjuvant therapy, surgical treatment plans, and survival status. Survival curves for overall survival (OS) and disease-free survival (DFS) were generated to explore prognostic factors in patients under 30.</p><p><strong>Results: </strong>Among the 66 patients, tongue cancer was predominant, accounting for 60/66 (90.9%). Female patients had no history of smoking, alcohol consumption, or betel nut chewing, whereas all male patients with a history of betel nut chewing were smokers. Patients who sought medical attention shortly after the onset of symptoms tended to demonstrate greater disease severity. The 5-year OS for these patients was 88.9%, and the 5-year DFS was 77.2%. Smoking, drinking, betel nut chewing, staging, LNM, and tumor histological differentiation were not associated with OS and DFS, whereas high neutrophil count and high monocyte count were associated with better survival outcomes.</p><p><strong>Conclusion: </strong>Our study dataset shows that OSCC patients under 30 are a subgroup with a high prevalence of tongue cancer, distinct etiological factors in females, and increasing proportions of betel nut chewing and moderately/poorly differentiated tumors. This subgroup generally has a favorable prognosis, but the prognostic factors differ from those in the general OSCC population.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"150"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472414","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fracture resistance of endocrowns made from different CAD/CAM materials after prolonged fatigue aging.","authors":"Arslandaş Dinçtürk B, Sufyan Garoushi, Kedici Alp C, Vallittu Pk, Üçtaşlı Mb, L Lassila","doi":"10.1007/s00784-025-06241-4","DOIUrl":"10.1007/s00784-025-06241-4","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the fracture resistance of endocrowns made of experimental short fiber-reinforced CAD/CAM block (SFRC CAD) in comparison with different commercial CAD/CAM materials.</p><p><strong>Materials and methods: </strong>In this study, 60 sound mandibular molar teeth with similar occlusal sizes (± 1 mm) were used. Standard preparations simulating an endocrown cavity were prepared and the teeth were divided into four groups randomly. After the digital photoimpression of the prepared cavities using a dental intraoral scanner (CEREC), the restorations were designed (4 mm high) and milled using IPS e.max, Cerasmart 270, Katana Avencia and SFRC CAD blocks (n = 15/per group). Restorations were cemented with self-adhesive dual-cure resin cement (G-Cem One). The specimens were immersed in a 37 °C water bath within the chewing simulator. Following cyclic fatigue aging for 1.000.000 cycles (F_max=150 N), a quasi-static load was applied using a universal testing machine at a speed of 1 mm/min. Fractography analysis was conducted using optical microscopy.</p><p><strong>Results: </strong>According to the data obtained, there are statistically significant differences in fracture resistance values between different CAD/CAM materials (p < 0.05). The highest values were observed in the experimental SFRC CAD group (3025 N), while the lowest values were observed in the IPS e.max group (2295 N).</p><p><strong>Conclusions: </strong>The type of CAD/CAM restorative material influences the fracture resistance of endocrowns. SFRC CAD blocks could potentially serve as an alternative material for endocrown restorations in the future.</p><p><strong>Clinical relevance: </strong>Endocrowns fabricated from SFRC CAD blocks have demonstrated promising fracture behavior, suggesting their suitability for clinical testing.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"149"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11845440/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143472412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Tooth discoloration induced by apical plugs with hydraulic calcium silicate-based cements in teeth with open apices-a 2-year in vitro study.","authors":"Ralf Krug, C Ortmann, S Reich, B Hahn, G Krastl, S Soliman","doi":"10.1007/s00784-025-06178-8","DOIUrl":"10.1007/s00784-025-06178-8","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"148"},"PeriodicalIF":3.1,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555969","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional comparative analysis of upper central incisors external apical root resorption/ incisive canal changes in first premolar extraction cases: clear aligners Versus passive self-ligating fixed braces.","authors":"Waseem S Al-Gumaei, Hu Long, Xiaoqi Zhang, Haoxin Zhang, Yufei Tang, Qingsong Jiang, Guannan Hu, Wenli Lai, Fan Jian","doi":"10.1007/s00784-025-06217-4","DOIUrl":"10.1007/s00784-025-06217-4","url":null,"abstract":"<p><strong>Objective: </strong>To assess the upper central incisor's (U1) external apical root resorption (EARR) and incisive canal (IC) changes and their influencing factors under clear aligners and passive self-ligating fixed braces in first premolar extraction cases using CBCT.</p><p><strong>Materials and methods: </strong>This retrospective study included 60 participants (120 teeth) with similar baseline characteristics based on the American Board of Orthodontics discrepancy index scores. Participants were divided into clear aligner (CA) and passive self-ligating fixed appliance (FA) groups, with 30 participants per group. Pre- and post-treatment EARR, IC dimensional changes, U1-IC proximity, and orthodontic movements were analyzed through CBCT using Invivo 6.0.3 software. Descriptive and analytical statistics are performed, and a P-value < 0.05 is considered statistically significant.</p><p><strong>Results: </strong>The CA group exhibited statistically significantly lower U1-EARR compared to FA group. However, there were no significant differences in overall IC dimensions (P < 0.05). In FA, contact or invasion of U1 with IC are associated with a significant increase in EARR, but not in CA. The invasion also reveals significant reductions in IC dimensions in FA, whereas CA exhibited more limited changes (P < 0.05). Retraction and intrusion were significantly positively correlated with U1-EARR in FA, whereas intrusion only was correlated positively with U1-EARR in CA (P < 0.05). In both FA and CA, there was no significant correlation between the torque and U1 EARR (P > 0.05). Retraction, intrusion, and torque movements had differential impacts on IC dimensions in FA and CA treatments.</p><p><strong>Conclusion: </strong>In this study, our findings indicate that in cases involving the extraction of first premolars, Invisalign® clear aligners may have less U1-EARR than passive self-ligating fixed braces but no significant differences in the overall IC dimensions between both appliances. Clear aligners may reveal better outcomes in U1 EARR/IC changes concerning U1-IC proximity and different orthodontic movements. These findings may be necessary for orthodontists to consider during treatment planning.</p><p><strong>Clinical relevance: </strong>Clear aligners may be an appropriate choice in first premolar extraction cases, especially when the U1 is closer to IC or when there is a need for more retraction, intrusion, and torque. Their potential to reduce root resorption while preserving IC dimensions may make them more advantageous over passive self-ligating fixed braces in these scenarios.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"147"},"PeriodicalIF":3.1,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143466907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}