Association of tooth loss with circadian syndrome in US adults: the mediated role of systemic inflammation.

IF 3.1 2区医学 Q1 DENTISTRY, ORAL SURGERY & MEDICINE

Clinical Oral Investigations Pub Date : 2025-08-19 DOI:10.1007/s00784-025-06480-5

Yundong Liu, Yuhao Liu, Tao Yin, Mi He, Changyun Fang, Shifang Peng

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引用次数: 0

Abstract

Background: The current study was to investigate the associations of missing teeth or lost functional tooth units (FTUs) with circadian syndrome and the mediated effects of systemic inflammation as indicated by serum C-reactive protein (CRP).

Methods: Dentition examination, high-sensitivity serum CRP, and circadian syndrome data of 11,490 participants aged 18-80 years from US National Health and Nutrition Examination Survey 2015-2020 were analyzed. Generalized linear model and mediation effect model were used.

Results: After adjusting confounders, the numbers of missing teeth or lost FTUs and Ln-transformed CRP were positively associated with higher circadian syndrome prevalence (odds ratio and 95% confidence interval: missing teeth: 1.01(1.00, 1.01), P = 0.043; lost FTUs: 1.02(1.01, 1.03), P = 0.001; CRP: 1.23(1.20, 1.26), P < 0.001). Furthermore, positive associations between the numbers of missing teeth or lost FTUs and Ln-transformed CRP but inverse association between implant prosthesis and Ln-transformed CRP were observed after adjustment (β ± standard error: missing teeth: 0.012 ± 0.002; lost FTUs: 0.024 ± 0.005; implant prosthesis: -0.136 ± 0.053). Moreover, significant mediation effects of serum CRP were observed in the associations of missing teeth or lost FTUs with circadian syndrome. The mediated proportions (%) for missing teeth or lost FTUs were 32% and 20% respectively.

Conclusions: Missing teeth or lost FTUs were positively associated with serum CRP and circadian syndrome in US adults. Systemic inflammation partly mediated the association of missing teeth or lost FTUs with circadian syndrome.

Clinical relevance: Maintaining more natural teeth may be associated with lower circadian syndrome prevalence.

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美国成年人牙齿脱落与昼夜节律综合征的关系：全身性炎症的介导作用。

背景：本研究旨在研究缺牙或功能牙单位（FTUs）与昼夜节律综合征的关系，以及血清c反应蛋白（CRP）指示的全身性炎症的介导作用。方法：分析2015-2020年美国国家健康与营养调查中11490名18-80岁参与者的牙列检查、高敏血清CRP和昼夜节律综合征数据。采用广义线性模型和中介效应模型。结果：调整混杂因素后，缺牙或丢失ftu数量和ln -转化CRP与较高的昼夜综合征患病率呈正相关(优势比和95%置信区间：缺牙：1.01(1.00,1.01),P = 0.043；丢失ftu: 1.02(1.01, 1.03), P = 0.001；结论：美国成人缺牙或ftu丢失与血清CRP和昼夜综合征呈正相关。全身性炎症在一定程度上介导了牙齿缺失或ftu丢失与昼夜节律综合征的关联。临床相关性：保持更多的天然牙齿可能与较低的昼夜节律综合征患病率有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Oral Investigations 医学-牙科与口腔外科

CiteScore

6.30

自引率

5.90%

发文量

484

审稿时长

3 months

期刊介绍： The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.