Clinical Oral Investigations最新文献

{"title":"The role of vitamin D deficiency in the development and severity of oral lichen planus: a case-control study.","authors":"Rania Shalaby, Ghada Nabil, Sally Ibrahim, Ali Aw Kotb, Hatem Amer, Salsabeel Afifi","doi":"10.1007/s00784-025-06398-y","DOIUrl":"https://doi.org/10.1007/s00784-025-06398-y","url":null,"abstract":"<p><strong>Objectives: </strong>Examine the responsibility of Vitamin D (VD) deficit as a risk element in the development and severity of oral lichen planus (OLP) considering dietary habits, sex, sun exposure, socioeconomic class and psychological factors.</p><p><strong>Materials and methods: </strong>Blood samples from 35 OLP patients and 35 healthy controls were collected for the analysis of serum VD level (SVDL) by ELISA. Vitamin D deficiency was considered when SVDL was ≤ 20 ng/ml. Additionally, a structured questionnaire was used to analyze other possible confounders.</p><p><strong>Results: </strong>SVDL were statistically significant greater in the control group than the OLP group (P ≤ 0.001). There was difference between the 3 types of OLP with statistical significance in which the least values for SVDL were in erosive type (P ≤ 0.001). Furthermore, no statistically significant difference was found in SVDL between dysplastic and non-dysplastic lesions. In terms of VD deficiency, a statistically significant distinction was noticed between the two research sets (P ≤ 0.001) and was more pronounced in erosive and atrophic types than reticular types. Depression as well as sun exposure significantly affected number of patients having VD deficiency (P = 0.001, 0.027). Results revealed a statistically significant direct relation between SVDL and the OLP (odds ratio = 1.38; 95%CI = 1.18-1.617).</p><p><strong>Conclusion: </strong>VD deficiency plays a vital role in OLP and the development of more severe forms.</p><p><strong>Clinical relevance: </strong>It corroborates that VD deficiency is a probable risk factor of OLP and the development of more severe forms considering many confounders.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"320"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An in vitro analysis of marginal and internal fit of 3D-printed permanent molar endocrowns with different preparation designs.","authors":"Izim Turker Kader, Safa Ozer, Burcin Arican","doi":"10.1007/s00784-025-06414-1","DOIUrl":"https://doi.org/10.1007/s00784-025-06414-1","url":null,"abstract":"<p><strong>Objectives: </strong>The purpose of this study was to evaluate the influence of different preparation designs on the marginal and internal fit of 3D-printed permanent endocrowns.</p><p><strong>Materials and methods: </strong>Typodont maxillary right first molars were prepared and divided into four groups based on different preparation designs: Group 1- butt joint with 2 mm pulp chamber depth, Group 2- butt joint with 4 mm depth, Group 3- shoulder with 2 mm depth, and Group 4- shoulder with 4 mm depth (n = 16 each). The prepared teeth were scanned and replicated as 3D-printed resin dies. Permanent endocrowns were fabricated using a ceramic-filled hybrid material and seated with light-body silicone. All restorations were rescanned, and superimposition was performed using 3D analysis software to evaluate marginal, internal, pulp chamber, and overall gaps based on multipoint measurements at standardized locations. Data were statistically analyzed using Two-Way Robust ANOVA (p < 0.05).</p><p><strong>Results: </strong>No significant differences were found between preparation types and depths for internal and overall gap values (p > 0.05). However, the highest marginal gap was measured in Group 1 (0.08 mm; p = 0.017), while the largest pulp chamber gap was recorded in Group 4 (0.15 mm; p < 0.001).</p><p><strong>Conclusions: </strong>A 1 mm shoulder preparation with a 2 mm pulp chamber depth demonstrated superior marginal and pulp chamber fit compared to other designs. While internal fit did not significantly vary among groups, this design showed the most consistent adaptation overall, supporting its clinical preference for 3D-printed permanent endocrowns.</p><p><strong>Clinical relevance: </strong>Different preparation designs may affect the fit of endocrowns. Clinicians can prefer an endocrown preparation design of 1 mm shoulder preparation with a 2 mm pulp chamber to improve the adaptation of 3D-printed permanent endocrown restorations.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"319"},"PeriodicalIF":3.1,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144186729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Education moderates the association between self-rated oral health and oral health-related quality of life.","authors":"Tianqi Wang, Yunhao Zheng, Yanyu Sun, Na Wei, Liang Hao, Yuan Yue, Xin Xiong","doi":"10.1007/s00784-025-06395-1","DOIUrl":"https://doi.org/10.1007/s00784-025-06395-1","url":null,"abstract":"<p><strong>Objective: </strong>The concept of oral health-related quality of life (OHRQoL) has gained significant attention, and self-rated oral health (SROH)-a brief measure to evaluate oral health-has been reported to correlate with OHRQoL. The relationship between education and OHRQoL has shown divergent findings. This study aims to investigate the relationship among education, SROH and OHRQoL.</p><p><strong>Methods: </strong>This study involved 1917 participants and their demographic information, SROH and OHRQoL were collected. We used Oral Health Impact Profile-5(OHIP-5) to evaluate OHRQoL. Correlations between variables and moderating effect were conducted through statistical analysis.</p><p><strong>Results: </strong>A poorer SROH was significantly correlated with higher OHIP-5 scores (r = 0.41, p < 0.001). Although highly educated individuals exhibited higher OHIP-5 scores, the association was weak (r = 0.11, p < 0.001). After adjusting for confounders, OHIP-5 remained associated with SROH (p ≤ 0.035) and education (p ≤ 0.008).The orthogonal polynomial regression test showed that Education-Linear (β = 1.477, p < 0.001), SROH-Linear (β = 4.572, p < 0.001) and SROH-Quadratic (β = 1.155, p < 0.001) were significant. The interaction test between SROH-Linear and Education-Linear(β = 1.213, p = 0.035) was significant demonstrating the moderating effect of education between SROH and OHIP-5.</p><p><strong>Conclusion: </strong>SROH correlated with OHRQoL while education exhibited statistically significant but clinically negligible correlation with OHRQoL. Education moderated the relationship between SROH and OHRQoL.</p><p><strong>Clinical relevance: </strong>Education's moderating role suggests high-educated individuals may exhibit greater sensitivity and elevated expectations to oral health, intensifying the SROH-OHRQoL link. Considering the limited practical significance of education-OHRQoL, the role of education can be overlooked in similar population when using the OHIP scale.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"318"},"PeriodicalIF":3.1,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144173135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors influencing pocket closure in surgically-treated intraosseous defects. A retrospective analysis.","authors":"Anna Simonelli, Roberto Farina, Luigi Minenna, Chiara Scapoli, Leonardo Trombelli","doi":"10.1007/s00784-025-06396-0","DOIUrl":"10.1007/s00784-025-06396-0","url":null,"abstract":"<p><strong>Objectives: </strong>to evaluate the association between patient- and local- factors and pocket closure (i.e., probing depth, PD, ≤4 mm) following surgical treatment of intraosseous defects with the Single Flap Approach (SFA).</p><p><strong>Materials & methods: </strong>a retrospective analysis of data from previous studies was conducted on 101 defects treated with SFA alone or in combination with enamel matrix derivative with/without a bovine-derived xenograft. Pocket closure at 12 months was the primary outcome. Age, sex, smoking status, baseline PD, tooth type, depth of the supraosseous component, radiographic depth of the intraosseous component, defect angle, defect morphology, treatment modality were considered as candidate determinants in a bivariate logistic regression analysis. Backward stepwise regression was used to identify the optimal set of factors significantly associated with pocket closure.</p><p><strong>Results: </strong>12-month pocket closure occurred in 74.3% of cases. The probability of pocket closure was significantly associated with baseline PD (OR = 0.741, 95%CI: 0.565-0.973; p = 0.031) and defect morphology, with defects classified as \"mainly 1-wall\" and \"mainly 3-wall\" showing greater odds for pocket closure compared to \"mainly 2-wall\" defects (OR = 7.125, p = 0.006; and OR = 5.225, p = 0.006, respectively).</p><p><strong>Conclusions: </strong>When performed according to the SFA, regenerative surgical procedures are associated with high probability of pocket closure at 12 months. Intraosseous lesions with deeper pre-surgery PD and/or prevalent 2-wall morphology have lower probability to be closed.</p><p><strong>Clinical relevance: </strong>Data from the present study may be of use to the clinician who wants to optimize the odds for pocket closure at a deep intraosseous lesion that is being approached according to the SFA.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"316"},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12119774/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Probiotic-based irrigation solution reduces neutrophil extracellular trap formation and stimulates CRAMP antimicrobial peptide expression in rat teeth with induced periapical lesions.","authors":"Ana Paula Gomes-Moura, Lisa Danielly Curcino Araujo, Marília Pacífico Lucisano, Ricardo Barbosa Lima, Nilza Letícia Magalhães, Sérgio Luiz Salvador, Flávia Aparecida Chaves Furlaneto, Michel Reis Messora, Paulo Nelson-Filho, Raquel Assed Bezerra da Silva, Léa Assed Bezerra da Silva","doi":"10.1007/s00784-025-06383-5","DOIUrl":"https://doi.org/10.1007/s00784-025-06383-5","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of the probiotic Bifidobacterium animalis subsp. lactis (B. lactis) HN019, as an irrigation solution, on the expression of neutrophil extracellular traps (NETs) and the antimicrobial peptide CRAMP, in rats with induced periapical lesions.</p><p><strong>Methodology: </strong>Periapical lesions were induced in the first molars of forty-five Wistar Hannover rats, with an experimental period of 21 days. The animals were divided into groups based on the irrigating solution and the number of sessions. Semiquantitative analysis was performed using HE staining, neutrophil counts, and histomorphometric analysis of the periapical lesions. Additionally, immunohistochemistry for CRAMP and immunofluorescence for NETs markers such as H3Cit, MPO, and NE were conducted. qRT-PCR analysis was performed for CAMP, ELANE, MPO, and H3F3B.</p><p><strong>Results: </strong>The probiotic irrigation groups showed better results for periodontal ligament parameters (p = 0.03) and inflammatory infiltrate (p = 0.004). A single probiotic irrigation resulted in the highest absence of cementum and bone resorption (85.71% and 71.43%). The periapical lesion area was smaller (p = 0.002), and neutrophil counts showed no difference (p = 0.064). Lower immunolabeling for H3Cit (p = 0.002), MPO (p < 0.001), and NE (p = 0.001) was observed in probiotic-irrigated groups, with reduced gene expression of CAMP (p < 0.001), MPO (p = 0.002), and ELANE (p = 0.001).</p><p><strong>Conclusion: </strong>The probiotic-based irrigation solution was effective in reducing neutrophil extracellular trap formation. Additionally, the probiotic solution stimulated CRAMP expression and had a positive effect in preventing cementum and bone resorption.</p><p><strong>Clinical relevance: </strong>The results demonstrate the potential application of the probiotic-based irrigation solution as a promising therapeutic approach for the treatment of periapical lesions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"317"},"PeriodicalIF":3.1,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144157157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dynamic changes of dental plaque and saliva microbiota in OSCC progression.","authors":"Man Zhang, Hailin Zhang, Ao Hong, Jing Huang, Lirong Yang, Ying Long, Zheng Yu","doi":"10.1007/s00784-025-06391-5","DOIUrl":"https://doi.org/10.1007/s00784-025-06391-5","url":null,"abstract":"<p><strong>Objectives: </strong>To elucidate the changes in microbial composition and genomics in saliva and dental plaque during the progression of Oral Squamous Cell Carcinoma (OSCC), and to identify virulence factors and pathways associated with tumor differentiation in OSCC patients.</p><p><strong>Materials and methods: </strong>Using metagenomic sequencing, 64 saliva and dental plaque samples from OSCC patients at different stages of differentiation were examined.</p><p><strong>Results: </strong>The results showed notable differences in the microbial composition and genomic profiles across ecological regions and differentiation degrees. Notably, the relative abundance of specific microbes, such as Porphyromonas gingivalis, Fusobacterium nucleatum, and Haemophilus parainfluenzae, increased in poorly differentiated OSCC. Microbial alpha diversity in dental plaque and saliva correlates with tumor T staging. Dental plaque microbiota shows higher specialization, especially in poorly differentiated tumors. Both microbiota types become more stable with advanced T staging. Genomic analysis reveals increased virulence factors in poorly differentiated stages.Subsequently, functional pathway analysis and tracing of pathogens reveal specific microbial mechanisms in oral cancer pathogenesis. Certain oral pathogens may promote tumorigenesis by secreting factors like GAPDH (glyceraldehyde-3-phosphate dehydrogenase), GspG (a gingipain precursor), and AllS (a lysine-specific gingipain precursor).</p><p><strong>Conclusions: </strong>OSCC progression is associated with altered microbial composition, diversity, and genomic profiles in saliva and dental plaque. Poorly differentiated stages show higher abundance of pathogens and virulence factors, implicating them in tumorigenesis.</p><p><strong>Clinical relevance: </strong>Understanding the microbial and genomic changes in saliva and dental plaque during OSCC progression could aid in developing new diagnostic biomarkers and targeted therapies, potentially enhancing early detection, treatment efficacy, and patient prognosis. Maintaining oral microbiota homeostasis may also help prevent oral cancer.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"314"},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of molar incisor hypomineralization and characteristics of affected first permanent and second primary molars among children in Jeddah.","authors":"Heba Jafar Sabbagh, Abdulaziz Abdullah Alharthi, Abdullah Muslih Almushali, Sultan Osama Jiffri, Meshari Hussain Alkalbi, Ghazal Abdulhadi Bokhari, Fatmah Yousef Aljehani, Nada Othman Bamashmous, Khlood Baghlaf","doi":"10.1007/s00784-025-06390-6","DOIUrl":"https://doi.org/10.1007/s00784-025-06390-6","url":null,"abstract":"<p><strong>Background: </strong>Molar-incisor hypomineralization (MIH) results in teeth that are highly prone to dental caries, sensitive to temperature changes and challenging to restore due to the atypical cavities or coronal deformation.</p><p><strong>Objectives: </strong>This study aimed to assess the prevalence of MIH, the characteristics of affected first permanent molars (FPMs), and the relationship between MIH and hypomineralized second primary molars (HSPM) among primary school children in Jeddah, Saudi Arabia.</p><p><strong>Methods: </strong>Jeddah City was divided into three regions, and 12-schools were randomly selected through stratified sampling. The inclusion criteria involved 7 to 9 years old children who had at least one erupted FPM. The caries status was assessed using the World Health Organization (WHO) indices dmft/DMFT. The assessment of MIH was conducted based on the criteria established by the European Academy of Pediatric Dentistry at their meeting in Athens in 2003.</p><p><strong>Results: </strong>A total of 2,019 children participated with an MIH prevalence of MIH 18.3% (369 patients), and an HSPM prevalence of 1.8% (36 patients). The mean DMFT/dmft index was 5.99 ± 4.08. White creamy opacities were the most common presentation of FPMs and HSPM (about 80% of MIH-affected FPMs). A statistically significant association was found between MIH and HSPM and increased odds ratio of MIH with HSPM (P < 0.001, OR = 5.96, and 95% CI: 5.3-6.57).</p><p><strong>Conclusion: </strong>The prevalence of MIH was higher than compared to the reported Middle East studies. The white creamy opacities were the most common presentations of MIH. A strong association existed between MIH and HSPM and an increased risk of having MIH when the child was found to have HSPM.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"315"},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated landmark-based mid-sagittal plane: reliability for 3-dimensional mandibular asymmetry assessment on head CT scans.","authors":"Sophie Alt, Laurent Gajny, Françoise Tilotta, Thomas Schouman, Gauthier Dot","doi":"10.1007/s00784-025-06397-z","DOIUrl":"10.1007/s00784-025-06397-z","url":null,"abstract":"<p><strong>Objective: </strong>The determination of the mid-sagittal plane (MSP) on three-dimensional (3D) head imaging is key to the assessment of facial asymmetry. The aim of this study was to evaluate the reliability of an automated landmark-based MSP to quantify mandibular asymmetry on head computed tomography (CT) scans.</p><p><strong>Materials and methods: </strong>A dataset of 368 CT scans, including orthognathic surgery patients, was automatically annotated with 3D cephalometric landmarks via a previously published deep learning-based method. Five of these landmarks were used to automatically construct an MSP orthogonal to the Frankfurt horizontal plane. The reliability of automatic MSP construction was compared with the reliability of manual MSP construction based on 6 manual localizations by 3 experienced operators on 19 randomly selected CT scans. The mandibular asymmetry of the 368 CT scans with respect to the MSP was calculated and compared with clinical expert judgment.</p><p><strong>Results: </strong>The construction of the MSP was found to be highly reliable, both manually and automatically. The manual reproducibility 95% limit of agreement was less than 1 mm for -y translation and less than 1.1° for -x and -z rotation, and the automatic measurement lied within the confidence interval of the manual method. The automatic MSP construction was shown to be clinically relevant, with the mandibular asymmetry measures being consistent with the expertly assessed levels of asymmetry.</p><p><strong>Conclusion: </strong>The proposed automatic landmark-based MSP construction was found to be as reliable as manual construction and clinically relevant in assessing the mandibular asymmetry of 368 head CT scans.</p><p><strong>Clinical relevance: </strong>Once implemented in a clinical software, fully automated landmark-based MSP construction could be clinically used to assess mandibular asymmetry on head CT scans.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"311"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive modelling of mandibular osteoradionecrosis in head and neck cancer patients: clinical and dosimetric insights.","authors":"Julian Leeder, Ali Modabber, Frank Hölzle, Michael J Eble, Ahmed Allam Mohamed","doi":"10.1007/s00784-025-06385-3","DOIUrl":"10.1007/s00784-025-06385-3","url":null,"abstract":"<p><strong>Introduction: </strong>Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) for head and neck cancer (HNC), with an incidence of 3-15%. ORN results from radiation-induced bone necrosis and may require surgical intervention. This study investigates clinical and dosimetric predictors of ORN risk and develops a predictive model for individualized risk assessment.</p><p><strong>Materials and methods: </strong>This retrospective case-control study included 298 HNC patients treated with RT or chemoradiotherapy between January 2012 and May 2020. Dosimetric parameters, including mandibular V10-V60, mean dose (Dmean), and maximum dose (Dmax), were analyzed alongside clinical data such as age, tumor site, smoking history, and dental extractions.</p><p><strong>Results: </strong>Over a median follow-up of 32.4 months, 20 patients (6.7%) developed ORN, with a 5-year cumulative incidence of 7.4%. Multivariate analysis identified mandibular V50 (HR = 1.05, p = 0.0015) and post-RT dental extractions (HR = 2.51, p < 0.0001) as significant ORN risk factors, while age was protective (HR = 0.96, p = 0.047). A V50 cutoff of 25.4 cm³ was most predictive (p = 0.0016). The multivariate model incorporating V50, age, and dental extractions demonstrated strong accuracy (C-index: 0.815, AUC: 0.8).</p><p><strong>Conclusion: </strong>V50 and post-RT dental extractions are key predictors of ORN. The developed nomogram enables personalized risk assessment, supporting treatment optimization. These findings emphasize the need for tailored RT planning and dental care to mitigate ORN risk, warranting validation in multi-institutional cohorts.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"313"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth pattern prediction of maxillary segments in infants with unilateral cleft lip and palate: a prospective in vivo study.","authors":"Sarah Bühling, Cedric Thedens, Sara Eslami, Iulia Dahmer, Babak Sayahpour, Nicolas Plein, Lukas Benedikt Seifert, Robert Sader, Stefan Kopp","doi":"10.1007/s00784-025-06378-2","DOIUrl":"10.1007/s00784-025-06378-2","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to identify the best prediction model for the growth pattern of the maxillary segments of infants with unilateral cleft lip and palate post birth and prior to the primary surgical cleft closure.</p><p><strong>Materials and methods: </strong>195 digital maxillary models of 50 infants with unilateral cleft lip and palate were collected during their preoperative alveolar molding therapy period. Intraoral scans were taken shortly after birth, at the monthly checkups and just before the surgical cleft closure at approximately 6 months of age. Surface measurements of maxillary segments were conducted using the diagnostic program OnyxCeph³™. For identifying the best fit for the growth pattern, mixed-effects regression models (fractional polynomials and B-splines) with the surface measurement as dependent variable, patient age (days) as predictor and the patient as random effect were fitted to the data. The best fit was selected according to the Akaike Information Criterium. A likelihood ratio test was performed for comparing the selected model with the intercept-only model.</p><p><strong>Results: </strong>The linear regression with mixed effects model showed the best fit for the total area, the area of the large segment and the area of the small segment. A highly significant association between the surface area and patient age was observed (p < 0.001). An increase of the area with time was estimated at 2.88 mm² per day for the total area, 1.62 mm² per day for the area of the large segment and 1.25 mm² per day for the area of the small segment. The likelihood ratio tests indicated that the linear regression models were significantly better than the intercept-only models for all the measured areas (p < 0.01).</p><p><strong>Conclusion: </strong>The growth pattern for the maxillary segments of patients with unilateral cleft lip and palate in the preoperative period can be best predicted by using a linear regression model. The growth curve model developed by the present study can be used in future treatment planning of patients with unilateral cleft lip and palate.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"312"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}