Clinical Oral Investigations最新文献

{"title":"Surgical complications and quality of life according to the extent of neck dissection in patients treated for oral squamous cell carcinoma.","authors":"Friedrich Mrosk, Haura Issa, Tim Hildebrandt, Lukas Mödl, Christian Doll, Kilian Kreutzer, Carsten Rendenbach, Jan Oliver Voss, Max Heiland, Steffen Koerdt","doi":"10.1007/s00784-025-06247-y","DOIUrl":"https://doi.org/10.1007/s00784-025-06247-y","url":null,"abstract":"<p><strong>Objective: </strong>Quality of life (QoL) and the degree of postoperative morbidity is an important aspect for patients suffering from oral squamous cell carcinoma (OSCC), which can be affected by several aspects of cancer treatment and especially the extent of surgical therapy. The aim of this study was to evaluate the clinical outcome and QoL in patients in relation to different types of neck dissection (ND) for OSCC.</p><p><strong>Materials and methods: </strong>In this observational single center cohort study, OSCC patients who underwent primary resection and ND between 2017 and 2022 were included and assessed for postoperative complications. Furthermore, a subcohort of patients who presented in regular tumor aftercare was prospectively examined regarding QoL and shoulder functioning, using a modified version of the EORTC quality of life core questionnaire with its head and neck cancer module (EORTC-QLQ-H&N43). Differences in QoL between patients were analyzed regarding the extent of ND (selective vs. modified radical ND; ipsilateral vs. bilateral ND), adjuvant therapy and presence of postoperative complications.</p><p><strong>Results: </strong>Overall, 350 patients with a mean age of 66 years (± 11.6) were enrolled in the study. The overall complication rate was 12.6%, while extended ND procedures (modified radical ND and bilateral ND) were associated with higher complications. A subcohort of 57 patients participated in QoL assessment. There were clinically relevant differences (20 points and more in QoL) in relation to the extent of ND in the following domains: impaired swallowing of solid food, mouth opening limitation, sticky saliva, impaired smelling, impaired eating ability, impaired speech, shoulder pain and stiffness in the neck and shoulder area, while selected objects were influenced by adjuvant therapy. While patients with extended neck treatment presented with significantly more shoulder pain, there were no significant differences in shoulder functioning among the different ND modalities.</p><p><strong>Conclusions: </strong>The results of this study provide an insight into QoL issues in relation to OSCC and may help to consult patients who are confronted at the beginning of the disease as well as by approaching selected health issues by specific functional treatment during follow-up.</p><p><strong>Clinical relevance: </strong>In this study, it could be shown that extensive surgical neck treatment is associated with higher complication rates and lower quality of life, highlighting the relevance of surgical de-escalation if feasible.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"177"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of facial pattern on the aesthetic assessment of the inclination of the occlusal plane in the frontal view.","authors":"Juan Cárdenas-Soria, Luis-Alberto Bravo-González, Ascensión Vicente","doi":"10.1007/s00784-025-06254-z","DOIUrl":"https://doi.org/10.1007/s00784-025-06254-z","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to analyse the aesthetic perception by orthodontists, dentists and laypeople of the different inclinations on the occlusal plane in the frontal view in relation to facial biotype.</p><p><strong>Materials and methods: </strong>The three groups of assessors evaluated the aesthetics of images with occlusal plane inclinations of 0º, 2º and 4º in a mesofacial, dolichofacial and brachyfacial face. Scores were assigned from 1 to 10 (\"1\": poor aesthetics and \"10\": very satisfactory aesthetics). The data were evaluated by the Kruskal-Wallis test (p < 0.05) and the Mann-Whitney test (Bonferroni correction p < 0.016).</p><p><strong>Results: </strong>In meso- and dolichofacial faces, orthodontists considered 0º occlusal plane inclination to be significantly more aesthetic than 2º (mesofacial p = 0.004, dolichofacial p < 0.001) and 4º (p < 0.001), and 2º inclination more than 4º (p < 0.001). Dentists and laypeople rated 0º and 2º inclinations as significantly more aesthetic than 4º (p < 0.001) with no significant differences between 0º and 2º inclinations. For the brachyfacial face, the three groups rated 0º and 2º occlusal plane inclination as significantly more aesthetic than 4º inclination (p < 0.001), with 0º and 2º inclinations scoring similarly (p > 0.016).</p><p><strong>Conclusions: </strong>Orthodontists were more critical than dentists and laypeople when assessing mesofacial and dolichofacial facial types, whereas no differences were observed between the three groups for brachyfacial faces.  CLINICAL RELEVANCE: The facial pattern influences the perception of the occlusal plane. Understanding these differences is crucial for clinicians, as it can enhance diagnostic accuracy and optimize treatment planning, leading to more personalized and effective orthodontic care.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"178"},"PeriodicalIF":3.1,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo comparison of initial caries lesions using the enamel decalcification index and quantitative light-induced fluorescence measurement during orthodontic therapy.","authors":"Priscila Ferrari-Peron, Lisa M Steuer, Irene Schmidtmann, Ambili R Mundethu, David Canzler, Heinrich Wehrbein, Christina Erbe","doi":"10.1007/s00784-025-06234-3","DOIUrl":"https://doi.org/10.1007/s00784-025-06234-3","url":null,"abstract":"<p><strong>Objectives: </strong>To compare two quantitative assessment methods - visual-tactile examination and fluorescence measurement - for detecting of initial caries lesions in adolescents undergoing treatment with a multibracket appliance (MB).</p><p><strong>Materials and methods: </strong>This study included 28 subjects (14 males, 14 females), treated with MB in both the maxilla and mandible. Data collection occurred at three times points: prior to treatment (T0), six months after MB insertion (T1), and one year post-insertion (T2). The Enamel Decalcification Index (EDI; 0-3 scale) and quantitative light-induced fluorescence (QLF) were employed for assessment.</p><p><strong>Results: </strong>At T0, four subjects (14%) exhibited no lesions, while only two (7%) remained lesion-free at T1, and again at T2. The kappa coefficient for agreement between the two diagnostic methods across all time points was 0.71.</p><p><strong>Conclusions: </strong>Both the QLF and EDI methods yielded similar results, with only minor discrepancies. To determine the most appropriate method for each individual case, considerations of cost, benefit and time should be made.</p><p><strong>Clinical relevance: </strong>The similarity in outcomes for the QLF and EDI methods indicates that both diagnostic methods are effective and reliable. However, QLF may be prone to interference, which must be accounted for during its application.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"174"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595825","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brushing motion caused no microcracks: a micro-computed tomography study.","authors":"Deniz Yanık, Şelale Özel, Fügen Dağlı Taşman Cömert","doi":"10.1007/s00784-025-06253-0","DOIUrl":"https://doi.org/10.1007/s00784-025-06253-0","url":null,"abstract":"<p><strong>Objective: </strong>We evaluated the effect of brushing motion on microcrack formation in round distal canals after using multi-file rotary(MFR), single-file rotary(SFR), and single-file reciprocation(SFRc) systems via micro-computed tomography(micro-CT).</p><p><strong>Materials and methods: </strong>Thirty-six mandibular molars were used. Samples were allocated according to files and preparation patterns (n = 12); pecking (P) and brushing (B): Group-MFR-P, Group-MFR-B, Group-SFRc-P, Group-SFRc-B, Group-SFR-P, Group-SFR-B. MFR was ProTaper Next, SFR was TruNatomy, and SFRc was WaveOne Gold. Mesial and distal were prepared using pecking motion, and additional brushing motion. Brushing motions were performed after the pecking motions with 6 strokes. Pre-and-post-instrumentation scans were obtained. Wilcoxon, Krukal-Wallis, and Mann-Whitney-U were performed.</p><p><strong>Results: </strong>No differences were between pre-and-post-instrumentation scans (p > 0.05). Post-instrumentation microcracks were not different in Group MFR-P and Group MFR-B, Group SFRc-P and Group SFRc-B, Group SFR-P and Group SFR-B (p > 0.05).</p><p><strong>Conclusion: </strong>The brushing motion followed by the pecking motion did not cause microcracks. None of the file systems examined in the study induced microcracks.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"173"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Radiation-induced changes in salivary metabolite profile and pathways in head and neck cancer patients.","authors":"Saga Ramsay, Eelis Hyvärinen, Wilfredo González-Arriagada, Tuula Salo, Marcio Ajudarte Lopes, Jopi J W Mikkonen, Bina Kashyap, Arja M Kullaa","doi":"10.1007/s00784-025-06251-2","DOIUrl":"https://doi.org/10.1007/s00784-025-06251-2","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"176"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143595761","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and risk factors affecting fibrinolytic alveolitis after permanent tooth extractions.","authors":"Anwar B Anwar Bataineh, Saleh T Alkadi","doi":"10.1007/s00784-025-06257-w","DOIUrl":"https://doi.org/10.1007/s00784-025-06257-w","url":null,"abstract":"<p><strong>Objectives: </strong>As a result of the blood clot breaking down or vanishing, a condition can occasionally arise following tooth extraction, especially after traumatic extraction, that leaves the exposed bone in the socket looking dry. The aim of this study was to investigate the incidence and risk factors associated with fibrinolytic alveolitis following extraction of permanent teeth in Jordan.</p><p><strong>Materials and methods: </strong>Data were collected over a period of 6 months from the Dental Management System for every patient who had permanent teeth extraction at the Oral Surgery Clinic, Faculty of Dentistry/ Jordan University of Science and Technology. Data were age, sex, systemic status of patients, smoking habits, indication of extraction, anatomical location of the extracted teeth was divided into: Upper teeth and lower teeth, number of tooth/teeth extracted, procedure involved in teeth extraction, complications during extraction, compliance to post extraction instructions, fibrinolytic alveolitis present.</p><p><strong>Results: </strong>During six-month period from October 2022 to March 2023 a total of 480 permanent teeth extractions of 316 patients, of which 204(64.56%) male patients and 112(35.44%) female patients, the ratio of male: female was1.8:1. Out of all 480 extractions the incidence of fibrinolytic alveolitis was 22(4.58%) of all extractions and 6.96% of affected patients.</p><p><strong>Conclusions: </strong>The overall incidence of fibrinolytic alveolitis was comparable to that of previous research. The findings also suggest that the method and location of extraction are important factors in the development of fibrinolytic alveolitis.</p><p><strong>Clinical relevance: </strong>Even though general dental offices often treat patients with fibrinolytic alveolitis, oral and maxillofacial surgeons play a critical role in treatment and achieving better results. The current theories around the prevention and treatment of fibrinolytic alveolitis, as well as the complexity and numerous natures of the etiology of fibrinolytic alveolitis, should be known to clinicians.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"175"},"PeriodicalIF":3.1,"publicationDate":"2025-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knowledge, assessment and treatment of molar incisor hypomineralisation (MIH) among German dentists.","authors":"Carla Ostermann, Christian Splieth, Mohammad Alkilzy","doi":"10.1007/s00784-025-06249-w","DOIUrl":"10.1007/s00784-025-06249-w","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigated the knowledge, perceptions, and clinical practices of German dentists regarding molar incisor hypomineralisation (MIH), a significant issue in paediatric dentistry. To date, no study has examined the knowledge and experience of German dentists with MIH.</p><p><strong>Subjects and methods: </strong>A digital questionnaire comprising 25 items was designed to assess German dentists' understanding of MIH. The questionnaire was available online via Survio.de from March to June 2023. The responses were entered anonymously into an Excel spreadsheet and analysed using SPSS 29.0.</p><p><strong>Results: </strong>625 dentists were surveyed, and 517 questionnaires were evaluated. 99.2% of respondents treated patients with MIH, and 92.5% considered it a significant clinical problem. Commonly observed clinical presentations included yellow/brown defects (81%), enamel loss (46%) and white defects (36.4%). 68.6% of respondents noted an increase in MIH prevalence. Treatment barriers included child behaviour (44.7%), difficulties with local anaesthesia (22.7%), and extended treatment duration (15.3%). Most dentists (77.8%) expressed a desire for further training on MIH.</p><p><strong>Conclusions: </strong>The data indicated that dentists' MIH management was influenced by specialisation and diagnostic confidence. Despite basic knowledge and experience, many respondents expressed a need for further education. Age-related biases and limited awareness of new techniques highlight the need for further research.</p><p><strong>Clinical relevance: </strong>Dentists must receive comprehensive training to enable them to diagnose and treat patients promptly. This should include the development of updated courses, which should be aligned with international guidelines.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"171"},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11885356/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress distribution in the closure of anterior maxillary diastemas using different restorative approaches: a finite element analysis.","authors":"Kevser Karakaya, Rahime Zeynep Erdem","doi":"10.1007/s00784-025-06258-9","DOIUrl":"10.1007/s00784-025-06258-9","url":null,"abstract":"<p><strong>Objective: </strong>This finite element analysis study aims to evaluate the effects of restoring 1 mm and 2 mm diastemas in maxillary anterior incisors with different CAD-CAM materials on stress distribution and to compare full crown and laminate veneer restorations.</p><p><strong>Materials and methods: </strong>Maxillary anterior tooth models simulating laminate veneer and full crown restorations were created. The experimental groups were categorized into four based on diastema width (1 mm and 2 mm) and CAD-CAM materials. Loads of 50 N, 150 N, and 250 N were applied vertically at 0° and obliquely at 30° and 60° angles to the central incisor's incisal midpoint. Von Mises stress values were analyzed numerically and visually with color-coded comparisons for all models.</p><p><strong>Results: </strong>When laminate veneer restorations were used to close diastemas, the highest stress values under a 250 N vertical load and 2 mm diastema were observed in the lateral incisor. IPS E.max exhibited a stress value of 166.88 MPa for the superstructure, while Lava Ultimate recorded 35.49 MPa in the lateral incisor. Within the dentin, the highest stress was 45.92 MPa for IPS E.max and 65.74 MPa for Lava Ultimate in the lateral incisor. When full crown restorations were employed, the highest stress values under a 250 N vertical load were again recorded in the lateral incisor. IPS E.max showed a stress value of 198.03 MPa for the superstructure, while Lava Ultimate demonstrated 40.80 MPa. The highest stress values within the dentin were 65.20 MPa for IPS E.max and 65.74 MPa for Lava Ultimate in the lateral incisor.</p><p><strong>Conclusions: </strong>This finite element analysis highlights that the type of restoration and diastema width significantly affect stress distribution in anterior teeth. IPS E.max material exhibited higher stress values, leading to more significant stress accumulation than other materials in laminate veneer and full crown restorations. Additionally, Lava Ultimate showed the highest stress values within the dentin. These findings underscore the importance of selecting appropriate CAD-CAM materials and restoration types to optimize stress distribution in diastema closures, providing critical insights for restoration planning.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"172"},"PeriodicalIF":3.1,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11889040/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143572339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Whitening efficacy and removal of extrinsic tooth stain of sodium phytate-containing whitening toothpaste: a randomized controlled trial.","authors":"Tianqiang Cui, Zhuoying Liu, Yina Cao, Qiqiu Wang, Lifen Li, Fengjuan Wu, Qinghui Zhi, Liangyue Pang","doi":"10.1007/s00784-025-06248-x","DOIUrl":"https://doi.org/10.1007/s00784-025-06248-x","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to evaluate the whitening efficacy and removal of extrinsic tooth stain of sodium phytate-containing whitening toothpaste, as well as to evaluate participant satisfaction.</p><p><strong>Methods: </strong>A total of eighty participants were recruited for this randomized, triple-blind controlled trial and were randomly assigned to either the test group (toothpaste containing 0.875% sodium phytate, ST) or the control group (toothpaste without sodium phytate, CT). Tooth color was assessed using a VITA spectrophotometer and changes in exogenous tooth stains were evaluated using the Lobene Index, which were conducted at baseline, as well as at 2, 3, and 4 weeks. Additionally, participants' self-assessment of tooth color were evaluated through an aesthetic numerical analogue scale. Statistical tests were conducted appropriately, and the significance level was established at α = 0.05.</p><p><strong>Results: </strong>This study demonstrates that the b-value of the index teeth in the ST group was significantly lower (p < 0.05) than that of the CT group, while the △WI_D values were significantly higher (p < 0.05) at both the 3-week and 4-week time points. Additionally, the a-value of the index teeth in the ST group was significantly lower (p < 0.05) compared to the CT group, and the L-value of the index teeth in the ST group was significantly higher (p < 0.05) than that of the CT group after 4 weeks. The differences in color between the two treatments, as analyzed by the CIELAB (ΔE), were not statistically significant. Similarly, no significant differences were observed in the changes of the Lobene Index or in participant satisfaction regarding tooth color between the two groups. A comparative analysis of the subjects in the ST group at the 3-week and 4-week marks revealed that the L-value of the index tooth at 4 weeks was significantly higher than that at 3 weeks (p < 0.001), while the b-value was significantly lower at 4 weeks compared to 3 weeks (p < 0.001).</p><p><strong>Conclusion: </strong>Brushing teeth with sodium phytate-containing whitening toothpaste for a duration of three weeks demonstrates notable whitening effects, which significantly increase over time. However, after four weeks, the sodium phytate-containing toothpaste shows minimal efficacy in removing extrinsic tooth stains.</p><p><strong>Clinical significance: </strong>Sodium phytate may be incorporated into toothpaste as a whitening agent.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"170"},"PeriodicalIF":3.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566258","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A comparative in vitro study on monomer release from flash-free or conventional bonding systems.","authors":"Baris Can Telatar, Gul Yildiz Telatar","doi":"10.1007/s00784-025-06250-3","DOIUrl":"10.1007/s00784-025-06250-3","url":null,"abstract":"<p><strong>Objectives: </strong>To examine the amount of residual monomer released from adhesive-precoated flash-free brackets and compare it to traditional light cure and chemical cure adhesives.</p><p><strong>Materials and methods: </strong>Sixty stainless steel brackets were bonded on upper premolar teeth using three groups of adhesive systems: Adhesive-precoated flash-free system, Transbond XT light cure, Sia chemical cure. The extracts of 0.5 ml of liquid samples were taken on the first, 7th, 21st, and 35th days. To determine the amount of residual monomer release, extracted samples were analyzed using a liquid chromatography device.</p><p><strong>Results: </strong>Urethane-dimethacrylate, triethylene glycol dimethacrylate, hydroxyethyl methacrylate and Bisphenol A-glycidyl methacrylate monomers were released from all study groups. The amount of total monomer release except hydroxyethyl methacrylate was detected as greater in adhesive-precoated flash-free system. Among the study groups, the chemical cure group showed the highest hydroxyethyl methacrylate monomer release.</p><p><strong>Conclusions: </strong>This in vitro study indicate that the APC flashless system exhibited the greatest release of residual monomers, suggesting that its possible cytotoxic effects need to be evaluated prior to clinical application.</p><p><strong>Clinical relevance: </strong>This is the first study that evaluates the residual monomer release from adhesive-precoated flash-free brackets. The novel bracket system has a different mesh structure at the bracket base compared to traditional systems with different chemical components which might alter the amount of residual monomer release. To investigate the harmful effects of adhesives used in orthodontic applications is very important for the health of the patient and the orthodontist.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 3","pages":"169"},"PeriodicalIF":3.1,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882616/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}